Clinical and cytokinetic aspects of remission induction of childhood acute lymphoblastic leukemia (ALL): addition of an anthracycline to vincristine and prednisone. Med Pediatr Oncol 1977;3(3):281-7
Date
01/01/1977Pubmed ID
284168DOI
10.1002/mpo.2950030310Scopus ID
2-s2.0-0017729897 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Fifty-six untreated patients with childhood with acute lymphoblastic leukemia (ALL) were randomized to receive one of three remission induction regimens: vincristine and prednisone (VP), vincristine, prednisone and daunorubicin (VPD), or vincristine, prednisone and adriamycin (VPA). The complete remission rate was similar for all three groups. Although the anthracycline regimens caused somewhat more rapid leukemic cell reduction than the VP only group, this difference was not significant. Labeling index reduction between study days 1 and 5 was significantly greater (p less than 0.001) with an anthracycline than for the VP group, but there was no difference between the two anthracyclines. Granulocytopenia during induction was significantly increased (p less than 0.05) in both the VPD and VPA groups as compared with VP alone. A significantly higher rate of infectious morbidity (p less than 0.01) was associated with the addition of either anthracycline, but to date no significant differences in remission duration or survival have been observed. The addition of anthracyclines to VP for remission induction in childhood ALL has theoretical advantages, but may be undesirable because of increased morbidity.
Author List
Sallan SE, Camitta BM, Frei E 3rd, Furman L, Leavitt P, Bishop Y, Jaffe NAuthor
Bruce m. Camitta Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Child, PreschoolDaunorubicin
Doxorubicin
Drug Evaluation
Drug Therapy, Combination
Female
Humans
Leukemia, Lymphoid
Male
Prednisone
Remission, Spontaneous
Vincristine
