Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis. Am J Surg 1989 Jan;157(1):145-9
Date
01/01/1989Pubmed ID
2910119DOI
10.1016/0002-9610(89)90437-6Scopus ID
2-s2.0-0024520148 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Previous studies have demonstrated that intravenous catalase infusion protects against the formation of pancreatic edema in cerulein-induced acute pancreatitis; however, polyethylene glycol (PEG)-conjugated catalase given as a bolus was not protective. Using radiolabeled catalase and PEG-catalase in subtherapeutic tracer doses, the pancreas tissue distributions of each were determined in rats with and without pancreatitis. Rats with cerulein-induced pancreatitis developed tissue concentrations of catalase within the pancreas that were three times those of PEG-catalase. The relatively low levels of PEG-catalase in the pancreas outside of the vascular compartment suggest that the failure to prevent edema formation may result from inability of PEG-catalase to reach extravascular sites of injury because of the large molecular size.
Author List
Guice KS, Oldham KT, Johnson KJAuthor
Keith Oldham MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAnimals
Catalase
Ceruletide
Drug Combinations
Edema
Male
Pancreas
Pancreatic Diseases
Pancreatitis
Polyethylene Glycols
Rats
Rats, Inbred Strains
