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Unraveling the Mystery of Goldblatt Hypertension. News Physiol Sci 1998 Aug;13:170-176

Date

06/08/2001

Pubmed ID

11390784

DOI

10.1152/physiologyonline.1998.13.4.170

Scopus ID

2-s2.0-22044435274 (requires institutional sign-in at Scopus site) 131 Citations

Abstract

In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.

Author List

Navar LG, Zou L, Von Thun A, Tarng Wang C, Imig JD, Mitchell KD

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