Aldosterone responses to ACTH during hypoxia in conscious rats. Clin Exp Pharmacol Physiol 1986;13(11-12):827-30
Date
11/01/1986Pubmed ID
3030587DOI
10.1111/j.1440-1681.1986.tb02388.xScopus ID
2-s2.0-0022909140 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
This study examined the aldosterone response to physiological ACTH infusion (4 ng/kg per min) and pharmacological ACTH injection (1.8 microgram) in conscious Long-Evans rats at 42 h of normoxia (21% O2) or hypoxia (10% O2). Hypoxia per se (no exogenous ACTH) significantly decreased control aldosterone levels despite elevated endogenous plasma ACTH). Hypoxia attenuated the aldosterone responses to ACTH infusion but not to ACTH injection. It was concluded that hypoxia attenuates aldosterone responses to small increases in ACTH, and large increases in ACTH can override this apparent decrease in adrenocortical sensitivity.
Author List
Raff H, Chadwick KJAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenocorticotropic HormoneAldosterone
Animals
Hypoxia
Infusions, Intravenous
Injections, Intravenous
Male
Rats
