Immunosuppressant combinations in primate cardiac xenografts. A review. Ann N Y Acad Sci 1993 Nov 30;696:281-4
Date
11/30/1993Pubmed ID
8109832Scopus ID
2-s2.0-0027767694 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
ABO matched cynomolgus monkey to baboon heterotopic xenografts were performed using three different immunosuppressant regimens. Group 1 (n = 4) baboons, which did not receive immunosuppression, had a mean graft survival of 9 days. Group 2 (n = 6) received cyclosporine (CsA) and methylprednisolone acetate which prolonged graft survival to an average of 78 days. Group 3 (n = 5) received CsA, Pred, and azathioprine (Aza) as well as steroid pulses and antithymocyte globulin (ATG) for rejection episodes. Survival in this group averaged 94 days. In Group 4 (n = 3), the same regimen as group 3 was used; however, Mycophenolate Mofetil was substituted for Aza. This resulted in a mean survival of 296 days. Histologic examination of the coronary vasculature in baboons treated with Mofetil showed a reduction in vascular pathologic changes when compared to those treated with Aza. Long-term cardiac xenograft survival is possible using currently available immunosuppressive agents.
Author List
McManus RP, O'Hair DP, Komorowski R, Scott JPAuthor
John Paul Scott MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDrug Therapy, Combination
Graft Rejection
Heart Transplantation
Immunosuppressive Agents
Macaca fascicularis
Myocardium
Papio
Transplantation, Heterologous
