Intracarotid dopamine infusion does not prevent acclimatization to hypoxia. Respir Physiol 1998 Jan;111(1):33-43
Date
03/13/1998Pubmed ID
9496470DOI
10.1016/s0034-5687(97)00100-xScopus ID
2-s2.0-0031963147 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Ventilatory acclimatization to hypoxia (VAH) is the time-dependent increase in ventilation that occurs during sustained exposure to hypoxia. The mechanism for VAH remains elusive. We sought to determine whether a deficiency in the availability of carotid body dopamine is the mechanism of increased ventilatory responsiveness to hypoxia during VAH in awake goats. This was based on the evidence that dopamine (DA) is primarily an inhibitory neuromodulator of carotid body (CB) function. The hypothesis was tested by intracarotid infusion of DA (5.0 micrograms kg-1 min-1) throughout VAH. VAH was not prevented by DA infusion, failing to support the hypothesis. We conclude that a deficiency in the availability of inhibitory DA release within the CB is probably not responsible for VAH. However, increased ventilatory responses to acute hypoxia after either prolonged DA infusion or hypoxia may have similar CB mechanisms.
Author List
Janssen PL, Dwinell MR, Pizarro J, Bisgard GEAuthor
Melinda R. Dwinell PhD Associate Dean, Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcclimatizationAnimals
Carotid Body
Chemoreceptor Cells
Dopamine
Female
Goats
Hypoxia
Infusions, Intra-Arterial
Male
Pulmonary Ventilation
