Prospective comparison of traditional and pharmacokinetic aminoglycoside dosing methods. Crit Care Med 1988 Sep;16(9):840-3
Date
09/01/1988Pubmed ID
3402229DOI
10.1097/00003246-198809000-00004Scopus ID
2-s2.0-0023754003 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Aminoglycoside (gentamicin, tobramycin) dosage regimens and subsequent serum concentrations were compared in 30 patients treated initially using traditional physician-determined methods and then switched to a pharmacokinetic-based treatment program. Patients received more drug during the kinetic phase (median 5 mg/kg) than during the traditional phase (median 3.6 mg/kg) and achieved greater peak serum concentration (5.9 vs. 4.4 micrograms/ml). Seventy-three percent of kinetic peak values but only 27% of traditional peak values exceeded 5.0 micrograms/ml. Trough concentrations were comparable in both phases of study and no nephrotoxicity was observed. This pharmacokinetic-based management program achieved more consistently greater therapeutic peak concentrations and provided more individualized therapy than did physicians. The use of pharmacokinetic consultants may be of benefit in administering safely optimal aminoglycoside therapy.
Author List
Franson TR, Quebbeman EJ, Whipple J, Thomson R, Bubrick J, Rosenberger SL, Ausman RKAuthor
Edward J. Quebbeman MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
GentamicinsHumans
Pharmacy Service, Hospital
Prospective Studies
Referral and Consultation
Tobramycin
