Faculty Collaboration Database

Differential reactivity to 5-hydroxytryptamine in canine coronary arteries. Blood Vessels 1986;23(4-5):165-72

Date

01/01/1986

Pubmed ID

3779106

DOI

10.1159/000158639

Scopus ID

2-s2.0-0023006136 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Responses to 5-hydroxytryptamine (5HT) were compared in large [2.1-3.0 mm outside diameter (OD)], medium (1.5-1.8 mm OD) and small (0.5-1.0 mm OD) isolated canine coronary arteries. 5HT produced contraction of large and medium arteries, with the maximal response averaging 35.1 +/- 4.0 and 21.0 +/- 3.3%, respectively, of the contraction to 100 mM KCl. Endothelial removal increased the response to 5HT, with the maximal response averaging 43.6 +/- 12.6 and 32.4 +/- 7.5%, respectively, of the 100 mM KCl contraction. Small arteries did not contract significantly to 5HT in the presence or absence of endothelium. However, 5HT (10(-6) M) contracted small arteries that were contracted with 30 mM KCl, averaging 130 +/- 3% of the original contraction to KCl. This further contraction to 5HT was slightly potentiated by removal of the endothelium. We conclude that, unlike larger epicardial arteries, coronary arteries less than 1 mm OD are unresponsive to 5HT under resting conditions. Failure of small arteries to contract to 5HT cannot be explained by an inhibitory influence of the endothelium. However, 5HT enhances the contraction of small arteries to K+, and this response tends to be augmented by endothelial removal.

Author List

Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP

Author

David Gutterman MD Emeritus Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Coronary Vessels
Dogs
Dose-Response Relationship, Drug
Endothelium
Female
Male
Serotonin
Vasoconstriction