Aminoglycoside serum concentration sampling via central venous catheters: a potential source of clinical error. JPEN J Parenter Enteral Nutr 1987;11(1):77-9
Date
01/01/1987Pubmed ID
3820521DOI
10.1177/014860718701100177Scopus ID
2-s2.0-0023146004 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Two patients receiving aminoglycosides via central venous Silastic catheters were noted to have serum drug concentrations markedly divergent from expected results. Study of these patients, and of four additional patients prospectively selected for study, demonstrated that three of five patients had higher peak and/or trough aminoglycoside serum concentrations--when blood was obtained from the central venous catheter--than were contained in simultaneous samples from peripheral blood; these divergent results were noted after the catheter had been in use for more than 1 week; divergent results were not improved by additional catheter flushing prior to central venous blood sampling. These observations suggest that spurious aminoglycoside serum concentration results may sometimes be obtained when blood sampling is performed from central venous Silastic catheters, and can result in improper drug dosage alterations. It is necessary to access the timing, processing, and reliability of serum drug-monitoring practices on a routine basis to preclude such problems, and to reassess individual patient-monitoring studies which are inconsistent with anticipated results.
Author List
Franson TR, Ritch PS, Quebbeman EJAuthor
Edward J. Quebbeman MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCatheters, Indwelling
Female
Humans
Medication Errors
Prospective Studies
Silicone Elastomers
Tobramycin
Veins
