Faculty Collaboration Database

Growth velocity in pediatric bone marrow transplantation: significance of donor type and treatment factors. J Pediatr Oncol Nurs 2009;26(6):377-82

Date

12/25/2009

Pubmed ID

20032299

DOI

10.1177/1043454209340319

Scopus ID

2-s2.0-73249135212 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Children who have undergone bone marrow transplantation (BMT) often have decreased growth. Growth is a multifactorial process, and the factors that influence growth after BMT are not completely understood. The authors hypothesized that donor type may be a factor influencing growth. Sixty-five children and adolescents who underwent BMT (32 related matched, 33 unrelated matched) were evaluated. Growth velocity (height standard deviation) was assessed prior to and 2 years following BMT. The results indicated that children and adolescents who underwent unrelated matched transplants had lower growth velocity (P < .059) than those with related matched transplants. Those who received the standard conditioning regimen that included total body irradiation (TBI) had a significantly lower growth velocity (P < .045) than those with chemotherapy-only regimens. Significant correlates of growth velocity included younger age at BMT and pre-BMT growth velocity. Thus, donor type, age at BMT, prior treatment, and BMT conditioning regimens that include TBI may all affect growth post-BMT. Careful monitoring of growth velocity is required for patients who have received an unrelated donor BMT.

Author List

Anderson L, Schmidt D, Bingen K, Kupst MJ, Warwick A

Author

Kristin M. Bingen PhD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Age Factors
Bone Marrow Transplantation
Child
Child Development
Child, Preschool
Female
Graft vs Host Disease
Humans
Infant
Male
Neoplasms
Retrospective Studies
Risk Factors
Time Factors
Tissue Donors
Treatment Outcome