Faculty Collaboration Database

Epistasis between loci on chromosomes 2 and 6 influences human height. J Clin Endocrinol Metab 2006 Oct;91(10):3821-5

Date

07/20/2006

Pubmed ID

16849413

DOI

10.1210/jc.2006-0348

Scopus ID

2-s2.0-33749567371 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

CONTEXT: Human height is a typical and important complex trait, which is determined by both actions and interactions of multiple genes. Although an increasing number of genes or genomic regions have been discovered for their independent effects on height variation, no study has been performed to identify genes or loci that interact to control the trait.

OBJECTIVE: This study aimed to search for potential genomic regions that harbor interactive genes underlying human height.

METHODS: Here with a sample containing 3726 Caucasians, the largest one ever obtained from a single population of the same ethnicity among genetic linkage studies of human complex traits, we performed variance component linkage analyses of height based on a two-locus epistatic model. We examined pairwise genetic interaction among three regions, 9q22, 6p21, and 2q21, which achieved significant or suggestive linkage signals for height in our recent whole genome scan.

RESULTS: Significant genetic interaction between 6p21 and 2q21 was detected, with 2q21 achieving a maximum LOD score of 3.21 (P = 0.0035) under the epistatic model, compared with a maximum LOD score of 1.63 under a two-locus additive model. Interestingly, 6p21 contains a cluster of candidate genes for skeletal growth, suggesting a mechanism whereby 2q21 regulates height through 6p21.

CONCLUSION: By providing the first evidence for genetic interaction underlying human height variation, this study further delineated the genetic architecture of human height and contributed to the genetic dissection of human complex traits in general.

Author List

Liu YZ, Guo YF, Xiao P, Xiong DH, Zhao LJ, Shen H, Liu YJ, Dvornyk V, Long JR, Deng HY, Li JL, Deng HW

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Body Height
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Epistasis, Genetic
Female
Humans
Lod Score
Male
Middle Aged