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Angiotensin II- and angiotensin 3-induced aldosterone release vivo in the rat. Science 1974 May 31;184(4140):994-6

Date

05/31/1974

Pubmed ID

4363578

DOI

10.1126/science.184.4140.994

Scopus ID

2-s2.0-0016239930 (requires institutional sign-in at Scopus site)   105 Citations

Abstract

The potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence.

Author List

Campbell WB, Brooks SN, Pettinger WA

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Alanine
Aldosterone
Angiotensin II
Animals
Dose-Response Relationship, Drug
Male
Rats
Sarcosine