Faculty Collaboration Database

Cellular immune response to viral peptides in patients exposed to HIV. AIDS Res Hum Retroviruses 1988 Aug;4(4):259-67

Date

08/01/1988

Pubmed ID

2462895

DOI

10.1089/aid.1988.4.259

Scopus ID

2-s2.0-0023762615 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

In efforts to identify B cell and T cell epitopes of HIV-1 structural components, serum as well as lymphocytes from HIV-1-seropositive individuals were reacted with several recombinant and native peptides representing defined viral gag and env determinants. Several areas of discordance between humoral and cellular reactivity were identified. Specifically, the principal neutralizing site within HIV-1, the major envelope glycoprotein gp120, failed to elicit detectable cellular reactivities. The carboxyl portion of gp120 and the transmembrane gp41 region were uniformly recognized by patient antibodies but did not produce significant lymphocyte blastogenesis. However, the amino half of gp120 elicited cellular responses in a majority of the immunocompetent individuals tested, despite its extremely low reactivity with patient sera. Last, the major HIV-1 structure component p24 was found to be the most consistent T cell activation antigen among the panel tested.

Author List

Ahearne PM, Matthews TJ, Lyerly HK, White GC, Bolognesi DP, Weinhold KJ

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acquired Immunodeficiency Syndrome
B-Lymphocytes
Enzyme-Linked Immunosorbent Assay
Epitopes
Gene Products, gag
HIV Antigens
HIV Seropositivity
HIV-1
Humans
Immunity, Cellular
Reference Values
Retroviridae Proteins
T-Lymphocytes
Viral Envelope Proteins