Faculty Collaboration Database

Antianalgesic action of nociceptin originating in the brain is mediated by spinal prostaglandin E(2) in mice. J Pharmacol Exp Ther 2001 Jan;296(1):7-14

Date

12/21/2000

Pubmed ID

11123356

Scopus ID

2-s2.0-0035193092 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

An antianalgesic action of intracerebroventricularly administered nociceptin was elicited against intrathecal morphine-induced antinociception in the tail-flick test in mice and investigated as a descending neuronal system for the spinal mediator involved. The nociceptin-induced antianalgesia originating in the brain was inhibited by intrathecally administered indomethacin and suggested the mediation of spinal prostaglandin. The antianalgesic action of intracerebroventricular nociceptin was closely matched by intrathecal prostaglandin (PG) E(2). Both shifted the dose-response curve of morphine to the right and these actions were eliminated by intrathecal PGD(2.) Desensitization of the antianalgesic action of PGE(2) by intrathecal PGE(2) pretreatment also produced cross-desensitization to the antianalgesic action of intracerebroventricular nociceptin. Neither intracerebroventricular nociceptin nor intrathecal PGE(2) produced antianalgesia against the delta-receptor agonists given intrathecally. Thus, the antianalgesic action of nociceptin originating in the brain is coupled to a descending neuronal pathway mediated by spinal PGE(2).

Author List

Rady JJ, Campbell WB, Fujimoto JM

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Analgesics, Opioid
Animals
Brain
Cyclooxygenase Inhibitors
Dinoprostone
Dose-Response Relationship, Drug
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Leucine
Indomethacin
Injections, Intraventricular
Injections, Spinal
Male
Mice
Morphine
Opioid Peptides
Pain Measurement
Receptors, Prostaglandin
Spinal Cord
Substance P