Cellular basis of tissue regeneration by omentum. PLoS One 2012;7(6):e38368
Date
06/16/2012Pubmed ID
22701632Pubmed Central ID
PMC3368844DOI
10.1371/journal.pone.0038368Scopus ID
2-s2.0-84862023925 (requires institutional sign-in at Scopus site) 72 CitationsAbstract
The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells.Omentum consists of a variety of phenotypically and functionally distinctive cells. To understand the mechanism of tissue repair support by the omentum in more detail, we analyzed the cell subsets derived from the omentum on immune and inflammatory responses. Our data demonstrate that the omentum contains at least two groups of cells that support tissue repair, immunomodulatory myeloid derived suppressor cells and omnipotent stem cells that are indistinguishable from mesenchymal stem cells. Based on these data, we propose that the omentum is a designated organ for tissue repair and healing in response to foreign invasion and tissue damage.
Author List
Shah S, Lowery E, Braun RK, Martin A, Huang N, Medina M, Sethupathi P, Seki Y, Takami M, Byrne K, Wigfield C, Love RB, Iwashima MMESH terms used to index this publication - Major topics in bold
Analysis of VarianceAnimals
Bleomycin
Blotting, Western
Bronchoalveolar Lavage
Cell Proliferation
DNA Primers
Flow Cytometry
Fluorescent Antibody Technique
Lung Injury
Mice
Mice, Inbred C57BL
Nitric Oxide Synthase Type II
Omentum
Osteopontin
Regeneration
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes
Tissue Engineering
Tissue Transplantation
Totipotent Stem Cells
