Faculty Collaboration Database

Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Radiat Oncol Biol Phys 2008 Apr 01;70(5):1546-51

Date

11/22/2007

Pubmed ID

18029109

Pubmed Central ID

PMC2386758

DOI

10.1016/j.ijrobp.2007.08.041

Scopus ID

2-s2.0-40949138809 (requires institutional sign-in at Scopus site)   73 Citations

Abstract

PURPOSE: To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT).

METHODS AND MATERIALS: A total of 55 subjects undergoing total body irradiation (TBI)-HSCT were enrolled in this randomized controlled trial. Captopril or identical placebo was started at engraftment and continued as tolerated until 1 year after HSCT.

RESULTS: The baseline serum creatinine and calculated glomerular filtration rate (GFR) did not differ between groups. The 1-year serum creatinine level was lower and the GFR higher in the captopril compared with the placebo group (p = 0.07 for GFR). Patient survival was higher in the captopril compared with the placebo group, but this was also not statistically significant (p = 0.09). In study subjects who received the study drug for more than 2 months, the 1-year calculated GFRs were 92 mL/min and 80 mL/min, for the captopril and placebo groups, respectively (p = 0.1). There was no adverse effect on hematologic outcome.

CONCLUSIONS: There is a trend in favor of captopril in mitigation of chronic renal failure after radiation-based HSCT.

Author List

Cohen EP, Irving AA, Drobyski WR, Klein JP, Passweg J, Talano JA, Juckett MB, Moulder JE

Authors

William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin
Julie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Angiotensin-Converting Enzyme Inhibitors
Captopril
Child
Creatinine
Glomerular Filtration Rate
Hematopoietic Stem Cell Transplantation
Humans
Kidney Failure, Chronic
Prospective Studies
Statistics, Nonparametric
Whole-Body Irradiation