Immunological enhancement of rat small intestinal allografts. Arch Surg 1978 May;113(5):615-7
Date
05/01/1978Pubmed ID
646623DOI
10.1001/archsurg.1978.01370170077015Scopus ID
2-s2.0-0018146462 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
In an attempt to evaluate whether survival of rat intestinal allografts could be extended by the administration of enhancing serum, Lewis-Brown Norway small intestine was transplanted to Lewis recipients, using microsurgical techniques. Only multiple injections of serum, administered on alternate days, resulted in a prolongation of survival by a few days. Neither graft irradiation nor a single injection of antiserum was effective in increasing survival time of the transplanted intestine. Clinical trials of intestinal transplantation from cadaver donors will probably have to await a clearer understanding of various methods of altering host responsiveness to foreign tissue. At the present time, central venous nutrition offers the best solution to the patient with an insufficient length of small intestine.
Author List
Telford GL, Corry RJMESH terms used to index this publication - Major topics in bold
AnimalsGraft Rejection
Histocompatibility
Immune Sera
Injections, Intravenous
Intestine, Small
Rats
Transplantation Immunology
Transplantation, Homologous
