Medical College of Wisconsin
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CURRICULUM VITAE

Rodney E. Willoughby MD
Professor
Department of Pediatrics
Division of Pediatrics Infectious Diseases

OFFICE ADDRESS:
999 N. 92nd Street
Milwaukee, WI 53226
Phone: +1 (414) 3377070
Fax: 414-337-7093
Email: rewillou@mcw.edu

EDUCATION:
1973 - 1977 A.B., Princeton University, Princeton, NJ
1977 - 1982 M.D., Johns Hopkins School of Medicine, Baltimore, MD

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1982 - 1984 Resident in Pediatrics (PL1-PL2), Pediatrics, UCSD, San Diego, CA
1984 - 1985 Resident in Pediatrics (PL3), Pediatrics, Johns Hopkins, Baltimore, MD
1985 - 1988 Fellowship Pediatric Infectious Diseases, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD
1988 - 1993 Postdoctoral Fellowship Carbohydrate Biochemistry, Biological Chemistry, Johns Hopkins, Baltimore, MD
1996 - Present Certificate Business of Medicine Program, Johns Hopkins, Baltimore, MD
1998 - 2004 PhD program - not completed, Graduate Training Program in Clinical Investigation, Johns Hopkins, Baltimore, MD

MILITARY SERVICE:
N/A

FACULTY APPOINTMENTS:
1989 - 1991 Instructor, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD
1991 - 2001 Assistant Professor, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD
2001 - 2004 Associate Professor, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD
2004 - 2009 Associate Professor, Pediatrics, Infectious Diseases, Medical College of Wisconsin, Milwaukee, WI
2009 - Present Professor with tenure, Pediatrics, Infectious Diseases, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
1994 - 2004 Director, Antibiotic Stewarship, Pediatrics, Johns Hopkins, Baltimore, MD
1994 - 1999 Director Clinical Infectious Diseases, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD
2010 - Present Director Antibiotic Stewardship Program, Children's Hospital of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
1994 - 1999 Director Fellowship Training Program, Pediatrics, Infectious Diseases, Johns Hopkins, Baltimore, MD

HOSPITAL STAFF PRIVILEGES:
1989 - 2004 Johns Hopkins Hospital, Baltimore, MD
2004 - Present Children's Hospital of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
Pediatrics (no expiration)
1988
None
Pediatric Infectious Diseases
1995
2030
   
AWARDS AND HONORS:
1982 - Present Alpha Omega Alpha, Johns Hopkins University
1982 - Present Phi Beta Kappa, Johns Hopkins University
1984 - Present Harriet Lane Fellowship, Department of Pediatrics, Johns Hopkins University
1988 - Present Physician Scientist Award, NIH Program Grant, Johns Hopkins University
1993 - Present Eli Lilly Clinician Scientist Award, Johns Hopkins University
1996 - 2004 Best Doctors in America®
2005 - Present Ultimate Health Care Hero, Small Business Times Health Care Heroes (health care team)
2006 - Present Childrens Miracle Achievement Award, Children's Miracle Network
2007 - Present Translational Research Award, Medical College of Wisconsin
2007 - 2016 Best Doctors in America®
2014 - Present Russell J Blattner Lectureship, Texas Children's Hospital
2014 - Present 22nd Annual Fred J Heldrich, MD Pediatric Breakfast and Lecture, Saint Agnes Hospital
2015 - Present American Academy of Pediatrics Unsung Heroes Award, to the Committee on Infectious Diseases
2104 - Present Superhero of Medicine, Wisconsin Medical Society

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Academy of Pediatrics

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1995 - 1998 Immunizations and Infectious Diseases, Medical and Chirurgical Faculty of Maryland
2008 - Present ad hoc Consultant, Bureau of Communicable Diseases, Wisconsin Division of Public Health

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1996 - 2000 Subboard of Pediatric Infectious Diseases, American Board of Pediatrics
1997 ad hoc member, Research Advisory Council, United Cerebral Palsy Research & Educational Foundation
1999 Working Group on Antimicrobial Cycling, Centers for Disease Control (USA)
1999 Workshop "Infection in Pregnancy and Neurodevelopment", Centers for Disease Control (USA)
2000 Consultant, Vaccines and Related Biological Products Advisory Committee, CBER, Food and Drug Administration
2003 Workshop "Laboratory Methods in Neurodevelopmental Epidemiology:, Centers for Disease Control (USA)
2003 Consultant, Task Force on Neonatal Encephalopathy and Cerebral Palsy, American College of Obstetrics and Gynecology
2005 ad hoc member, NIH) Special Emphasis Panel/Scientific Review Group 2005/05 ZAT1 JH (09), RFA AIDS, National Center for Complementary and Alternative Medicine NIH
2006 Consultant, Workshop "Rabies Treatment Working Group", Centers for Disease Control (USA)
2007 Rabies Treatment Working Group, Centers for Disease Control (USA)
2009 - 2015 Voting Member, Committee on Infectious Disease (COID) aka "Red Book", American Academy of Pediatrics
2013 "Approaches to improve vaccine uptake of the HPV vaccine", American Academy of Pediatrics
2013 Smallpox Vaccine Clinical Utilization Workshop, Centers for Disease Control and Prevention (USA)

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2002 Workshop "Roles for Cytokines in Developmental Disabilities", United Cerebral Palsy Foundation (USA) & Little Foundation (UK)
2007 National Training Workshop on Rabies PEP, Centers for Disease Control (Peoples Republic of China)
2009 Working Group "Rabies Treatment Protocol for Brazil", Ministry of Health, Brazil
2010 National Conference on Rabies Prevention and Control, Chinese Preventive Medicine Association (PRC)

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
"Rotaviruses bind specifically to the neutral glycolipid asialo-GM1",, U.S. and Japanese Viral Diseases Panels, U.S.-Japan Cooperative Medical Science Program., Annapolis, MD, 08/21/1989 - 08/23/1989
"Treatable Viral Infections in Pediatrics and Neonatology"; "Resistance to Antibiotics, with Special Emphasis on Penicillin-resistant Pneumococci"; "Treatment of Community-acquired Pneumonia, Osteoarticular Infections and Urinary Tract Infections", IV Jornadas Franco-Argentinas de Medicina y Cirugia, Hospital Frances, Buenos Aires, Argentina, 09/01/1997 - 09/02/1997
"Inflammation and Cerebral Palsy" (Plenary Session), 18th European Congress on Perinatal Medicine, Oslo, Norway, 06/06/2002
"Overview of infectious diseases and cerebral palsy in developed and underdeveloped countries", International Conference on Women and Infectious Diseases: From Science to Action, Atlanta, GA, USA, 02/28/2004
Survival from rabies through improvised use of a therapeutic coma, XVI International Conference on Rabies in the Americas, Ontario, Canada, 10/20/2005
"Rabies Management", XLII Congress of the Brazilian Society of Tropical Medicine, Teresina, PIaui, Brazil, 03/08/2006
"Human Rabies--Post-exposure prophylaxis and treatment in the 21st century" "Rabies--Pathogenesis and new treatments.", International Congress of Pediatrics, Athens, Greece, 08/25/2007 - 08/30/2007
"Antibody kinetics in the treatment of human rabies" ;"Milwaukee Protocol to treat human rabies", Faculty of Medical Sciences, University of Pernambuco, Recife, Pernambuco, Brazil, 02/09/2009
"Rabies pathophysiology"(Spanish); "Clinical manifestations and diagnosis of human rabies" (Spanish), 9th Colombian Congress on Infectious Diseases, Cali, Colombia, 05/26/2009 - 05/31/2009
"Rabies Update and Management Advances", Latin America Society for Pediatric Infectious Diseases (SLIPE), Punta Cana, Dominican Republic, 05/25/2011 - 05/28/2011
"Update on Rabies Therapy (the Milwaukee Protocol)" [in Spanish], Hospital Gustavo Fricke (Ministry of Health, Chile), Vin͂a del Mar, Chile, 01/09/2013
"Treatment of Human Rabies" [in Spanish], Institute for Public Health (Ministry of Health, Chile), Santiago, Chile, 01/10/2013
"Global Vaccine Update-2013" [in Spanish; representing the American Academy of Pediatrics], 62nd National Congress of the Spanish Pediatric Association, Sevilla, Spain, 06/07/2013
"Care of Rabies: Time for a Randomized Clinical Trial", One Health Commission International Symposium and Global Webinar on Human Rabies, and Rabies in the Americas conference, Global Webinar, Ft. Collins, Colorado (52 countries participating), 10/10/2015
"Rabies Treatment: the First 10 Years" [in Spanish], International Colloquium: Rabies in the Peruvian Amazon, Iquitos, Peru, 02/18/2016
"Treatment of Human Rabies: Into Double Digits of Survivors", One Health Commission International Symposium and Global Webinar on Human Rabies, and Rabies in the Americas conference, Global Webinar, Belem, Brasil, 10/26/2016
“Treatment of Human Rabies: Double Digits of Survivors” [in Spanish], National Forum of Laboratories of the Public Health Secretariat for the Diagnosis of Rabies, Mexico City, Mexico, 03/18/2017 - Present
“Milwaukee Protocol”, 2018 Rabies Conference in China, Changsha, China, 04/12/2017 - 04/13/2017
“Milwaukee Protocol” [in Spanish], Gaps and Opportunities for the investigation of rabies, zoonoses and emerging infections in Peru, Lima, Peru, 09/18/2017 - 09/20/2017
“Milwaukee Protocol”, Rabies Research and Treatment, Huazhong Agricultural University, Wuhan, China, 10/28/2017 - Present
“Milwaukee Protocol”, Fourth Joint Chinese ICU Community Summit Conference, Shenzhen, China, 10/28/2017 - Present
“Treatment of human rabies” [in Portuguese], 11th Seminar on Surveillance and Control of Rabies, Instituto Pasteur and Ministry of Health, Brazil, Sao Paolo, Brazil, 10/01/2018 - 10/04/2018
“Milwaukee Protocol: 17 survivors” [in Spanish], 3rd International Course and Workshop on Zoonosis: Current Scenarios and Interventions for Prevention and Control of Rabies and Other Zoonoses in the Amazon Region, Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales (CITBM), FONDECYT-CONCYTEC, Lima, Peru, 09/11/2019 - 09/13/2019
“Treatment of human rabies”, international webinar (recorded), European Union’s Horizon 2020 research and innovation programme under RABYD‐VAX grant agreement No 733176 (https://rabyd-vax.eu/webinar/), hosted through Rega Institute for Medical Research, University of Leuven, Leuven, Belgium, 01/14/2020 - 12/31/2020
“Treatment of human rabies” (zoom seminar) [in Portuguese], Pope John XXIII Hospital, Belo Horizonte, Minas Gerais, Brazil, 05/25/2022 - Present
“Treatment of rabies and application of the protocol” [in Portuguese], Zoonosis Webinar, Center for Zoonosis and Biological Risk Factor Surveillance, Minas Gerais State Health Service, Minas Gerais, Brazil, 11/08/2022 - Present
“Expert Session to Review Human Rabies Case in Nayarit 2022” [in Spanish], Subsecretariat for Prevention and Promotion of Health, National Center for Preventive Programs and Control of Infectious Diseases, Nayarit, Mexico, 01/06/2023 - Present
“Rabies Treatment: Lessons Learned”, U.S. Department of State International Visitors Leadership Program: Global Public Health Challenges for the Indo-Pacific --An Inter-Regional Project, Milwaukee, Wisconsin, 03/10/2023 - Present
“Milwaukee Protocol for the Treatment of Rabies”, Rabies in the Americas Conference, Bogota, Colombia, 10/19/2023 - Present
 
National
"Is Necrotizing Enterocolitis an Infectious Disease", Grand Rounds, Children's Hospital of the King's Daughters, Norfolk, Virgina, 02/11/1993
"Approach to the Child with Diarrhea"; "Antibiotic Therapy for Otitis Media and Sinusitis"; "Optimizing Outpatient Parental Therapy", Pediatric Infectious Disease Seminar, Hilton Head, South Carolina, 06/20/1995 - 06/24/1995
"Spastic CP and PVL: New Findings/New Work-Up" (Plenary Lecture), Infectious Diseases Society for Obstetrics and Gynecology, Incline Village, Nevada, 08/03/2000
"Recovery of a patient from rabies", University of Chicago Medicine-Pediatrics Speaker Series, Chicago, Illinois, 03/17/2005
"Batter up: Surviving Rabies" (Plenary Lecture), Society for Healthcare Epidemiology of America, Los Angeles, CA, 04/11/2005
"Rabies Management: A case report (or three)"., Infectious Diseases Conference, Miriam Hospital (Brown University), Providence, Rhode Island, 02/22/2006
"Rabies Management: A case report (or three)"., Pediatric Grand Rounds, Johns Hopkins Hospital, Baltimore, Maryland, 03/01/2006
"Rabies in Children", Pediatric Grand Rounds, University of Iowa, Iowa City, Iowa, 03/24/2006
"Treatment of rabies",, Pediatric Residency Conference, Children's Hospital of Oakland, Oakland, California, 11/22/2006
"Rabies",, Viral & Rickettsial Disease Laboratory, Department of Health Services, State of California, Richmond, California, 11/28/2006
"Treatment of rabies", Pediatric Grand Rounds, Maimonides Infants & Children's Hospital of Brooklyn (Mt. Sinai School of Medicine), Brooklyn, New York, 03/06/2007
"Update on human rabies therapy", World Rabies Day, Centers for Disease Control and Prevention, Atlanta, Georgia, 11/07/2007
"Current therapeutic approach to people with rabies", Meet-the-Professor, 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the Infectious Diseases Society of America (IDSA) 46th Annual Meeting, Washington, DC, 10/25/2008 - 10/28/2008
"Successfully treating human rabies", Pediatric Grand Rounds, Children's Hospital at Montefiori (Albert Einstein College of Medicine), Bronx, New York, 11/05/2010
"Treatment of rabies",, American Society of Tropical Medicine and Hygiene, Atlanta, Georgia, 11/09/2012
"Treatment of human rabies", Centers for Disease Control and Prevention, Atlanta, Georgia, 11/09/2013
"Rabies Therapy", Pediatric Grand Rounds, Nemours Children's Hospital, Orlando, Florida, 11/19/2013
"Treatment of rabies - the first 10 years", Russell J. Blattner Lectureship, Texas Children's Hospital, Houston, Texas, 04/04/2014
"Treatment of rabies - the first 10 years", The 22nd Annual Fred J. Heldrich, MD Pediatric Breakfast and Lecture, Saint Agnes Hospital (Johns Hopkins), Baltimore, Maryland, 05/02/2014
“Treatment of Human Rabies”, Seminar, Department of Veterinary Medicine, College of Natural Science and Mathematics, University of Alaska at Fairbanks, Fairbanks, Alaska, 05/02/2014 - 05/20/2014
“Treatment of human rabies: next step forward”, Medicine Grand Rounds, Flushing Hospital Medical Center, Queens, NY, 11/09/2021
 
Regional
“Gaseous Intoxication by Invasive Bacteria”, Society for Redox Biology and Medicine Regional Meeting, Milwaukee, WI, 05/13/2021 - 05/04/2021
"Vector-borne Infections", Annual Meeting, American Academy of Pediatrics, Maryland Chapter, St. Michael's, October 19, 1997.
"Cerebral Palsy: Current Concepts Regarding Etiology", 63rd Annual Meeting, Wisconsin Section/American College of Obstetricians and Gynecologists, July 23, 2004.
"Recovery from rabies", Winnebago County Medical Society, March 10, 2005.
"Survival from Rabies", Case Management Society of America, Milwaukee Chapter, Country Springs Hotel, Waukesha, Wisconsin, October 4, 2005
"Surviving Rabies", Association for Professionals in Infection Control, Southeast Wisconsin Chapter, Froedtert Hospital, Milwaukee, November 3, 2005
"Therapies for rabies: Supportive and specific", Clinical Laboratory Managers' Association, Radisson Hotel, Peewaukee, September 28, 2006
 
Local
"Rabies Management: A case report (or three)", Pediatric Grand Rounds/Translational Research Series, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, 01/06/2006
1996 Pharmacy Usage Working Group
1996 Ad Hoc Committee on Faculty Compensation
1996 - 1998 Children's Center Computer Committee
1989 - 1991 Intern Selection Committee
The Johns Hopkins Hospital
1994 - 1998 Infection Control Committee
The Johns Hopkins Hospital
1994 - 1998 RSV Joint SubCommittee
The Johns Hopkins Hospital
1994 - 1998 VRE Joint Subcommittee
The Johns Hopkins Hospital
1994 - 1998 Pharmacy and Therapeutics Committee
2002 - 2004 The John's Hopkins Hospital
1994 - 1998 Antibiotic Subcommittee
The John's Hopkins Hospital
2002 - 2004 Chair, Antibiotic Subcommittee
1996 Member, Ad Hoc Committee for Documentation of
2005 to present Clinical correlation--Rabies, Microbiology course
2004-Present Consultation Service, Pediatric Infectious Diseases, Medical College of Wisconsin, Attending Physician. Training of pediatric housestaff and students on elective.
2004-Present Infectious Diseases Interest Rounds (weekly city-wide infectious diseases conference), Periodic speaker.
2006-Present Pediatric Residency (PL-2) Journal Club
2/18/05 Faculty Academic Conference, Department of Pediatrics, Medical College of Wisconsin.
2010 Reviewer, Children's Research Insitute Pilot Innovative Research Awards
2016 Calendar Committee, Elmbrook School District, Wisconsin (changed school start times;
homework limitation)
1991-1998 Pediatric Noon Lecture Series: Rotating Topics. Lectures to Johns Hopkins Pediatric Housestaff and Medical Students at The Johns Hopkins Hospital, Baltimore, MD.
1994-1998 Basic Pediatric Clerkship Lecture Series: "Bacterial Meningitis", Quarterly lecture to Medical Students
1994-1998 Pediatric Subspecialty Lecture Series, St. Agnes Hospital, Baltimore, Maryland: Rotating Topics. Monthly lectures to Johns Hopkins Pediatric Housestaff and Medical Students on rotation at community hospital.
2001, 2004 Rational Therapeutics Course. Rational Antibiotic Use. Lecture to 4th year Medical Students, Johns Hopkins School of Medicine.
1998-2004 Joint Pediatric - Medicine Infectious Disease Case Conference, The Johns Hopkins Hospital. Regular discussant and facilitator at weekly conference for faculty, fellows, laboratory personnel, and medical students.
1990-2004 Consultation Service, Pediatric Infectious Diseases, The Johns Hopkins Hospital, Attending Physician. Training of clinical fellows, pediatric housestaff, and students on elective.
1991-1996 General Ward Attending, Department of Pediatrics, The Johns Hopkins Hospital. Supervision and education of pediatric housestaff and students enrolled in the basic pediatric clerkship.
1991-2004 Morbidity and Mortality Conferences, Department of Pediatrics, The Johns Hopkins Hospital. Regular discussant and participant at biweekly conference for pediatric faculty, fellows, housestaff and medical students.
1991-2004 Case Management Conferences, Department of Pediatrics, The Johns Hopkins Hospital. Regular discussant and participant at weekly conference for pediatric faculty, fellows, hosuestaff, and medical students.
1994-1998 Elective in Pediatric Infectious Diseases, Johns Hopkins School of Medicine. Preceptor for residents, medical students and residents in pharmacology. Clinical rotations and research electives.
1994-1999 Plate Rounds, Microbiology Laboratories, The Johns Hopkins Hospital. Weekly discussant and regular participant at daily conference for Pediatric Infectious Disease and Infectious Disease fellows, residents, and students on elective with either subspecialty.
1. Amanda Brandow, DO, (Candidate, MPH degree), Fellow in Pediatric Hematology-Oncology, 2006-2008
Present position: "Associate Professor, Department of Pediatrics, Medical College of Wisconsin; Associate Fellowship Program Director, Pediatric Hematology/Oncology Fellowship Program, Pediatrics, Medical College of Wisconsin
1. Jasjit Singh, MD, Fellow in Pediatric Infectious Disease, 1993-1995 (updated 2016)
2. Ann W. Funkhouser, MD, MS, Fellow in Pediatric Infectious Disease, 1994-1995 (updated 2008)
Present Position: Supervisory Medical Officer, Office of Surveillance and Epidemiology/DP II, Food & Drug Administration, Washington, D.C.
3. Syema Muzaffar, MD, MPH. Fellow in Pediatric Infectious Disease, 1994-1996 (updated 2016)
Present Position: Dell Children's Hospital, Austin, TX
Present Position: Associate Professor, Pediatrics, University of Colorado; Associate Director, Center for Global Health; President, Colorado Children's Immunization Coaltion
Present Position: Cesar Milstein Professor of Pediatrics, Vanderbilt University; Scientific Director, Fundacion INFANT, Buenos Aires, Argentina
Present Position: Professor, Dept. of Epidemiology, Johns Hopkins School of Public Health
Present Position: Associate Professor, Department of Pediatrics, The Johns Hopkins University
Present Position: Staff Physician, Center for Pediatric Infectious Diseases, Pediatric Institute, Cleveland Clinic; Principle Investigator, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic.
Present Position: Associate Professor, Dept. of Pediatrics, State University of New York, Syracuse, NY.
"A 14 Month Old Child with Reticulonodular Pulmonary Infiltrates", Clinical-Pathological Conference, Johns Hopkins Hospital, Baltimore, Maryland, January 8, 1992.
"Update on Rotavirus Infections", Grand Rounds, Department of Pediatrics, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, January 31, 1995.
"Encephalitis", Grand Rounds, Department of Pediatrics, St. Agnes Hospital, Baltimore, Maryland, September 8, 1995.
"A 12 year old Native American/Caucasian Boy with Fever, Headache, and Jaundice", Clinical-Pathological Conference, Johns Hopkins Hospital, Baltimore, Maryland, October 18, 1995.
"Antibiotic Resistance In Sickle Cell Disease", Hematology Grand Rounds, Johns Hopkins Hospital, Baltimore, Maryland, October 28, 1996.
"Antibiotic Update", Urology Grand Rounds, Johns Hopkins Hospital, Baltimore, Maryland, October 21, 1996.
"Receptor-based Therapy of Rotavirus Infections", Grand Rounds, Department of Pediatrics, Johns Hopkins Hospital, February 4, 1998.
"Antibiotic Resistance and Surgical Prophylaxis", Urology Grand Rounds, Johns Hopkins Hospital, Baltimore, Maryland, September 21, 2000.
"Is Cerebral Palsy an Infectious Disease?", Departmental Academic Program, Pediatrics, Johns Hopkins Medical and Surgical Association, June 6, 2001.
"Aspergillus Infections in Neutropenic Oncology Patients", Oncology Grand Rounds, Johns Hopkins Hospital, Baltimore, Maryland, June 14, 2002.
"Antimicrobial Resistance: Populations vs. Individuals", PICU Research Conference, Children's Hospital of Wisconsin, February 3, 2005
"Probiotics to Minimize Resistant Infections in Hospitals", Children's Research Institute Academic Conference, Children's Hospital of Wisconsin, May 19, 2005
"Probiotics in Neonates", Combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, Children's Hospital of Wisconsin and MCW Neonatology Speaker Series, Milwaukee, September 27, 2005
"Rabies Management A Case report (or Three)" Pediatric Grand Rounds, Children's Hospital of Wisconsin, January 6, 2006
"10-month Girl with Bloody Diarrhea after Open-heart Surgery" [Pneumatosis intestinalis, chloral hydrate, sorbitol] combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, Children's Hospital of Wisconsin, February 27, 2007
"Cerebral artery spasm in rabies and bacterial meningitis", Children's Research Institute Academic Conference, Children's Hospital of Wisconsin, March 23, 2007
"A 4-year old with pitchfork injury to his knee" [Myceliophthora thermophila] combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, November 22, 2007
"Attenuated (Live) Virus Vaccine Infections in Immunocompromised Patients", combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, Children's Hospital of Wisconsin, April 5, 2007
"Probiotics", Nutrition Conference, Children's Hospital of Wisconsin, September 19, 2007
"NSAIDs and Complicated Bacterial Pneumonia" combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, Children's Hospital of Wisconsin, September 25, 2007
"Metabolomics of human rabies" Children's Research Institute Academic Conference, Children's Hospital of Wisconsin, June 27, 2008
"A 5-month Hispanic male with seizures" [HHV-6] Combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, February 24, 2009
"An 11-month old with refusal to sit" [discitis] Combined Milwaukee Area ID Interest Rounds/CHW Pediatric Residency Conference, March 24, 2009
"Milwaukee Protocol for treating human rabies". Infectious Disease Research Conference, Medical College of Wisconsin/Froedtert Hospital, December 3, 2009
"A 10 day old term neonate with sepsis" [enterovirus myocarditis] Combined Milwaukee Area ID Interest Rounds, January 26, 2010
"A 17 year old with knee pain and hypotension" [Group A streptococcal osteomyelitis] Combined Milwaukee Area ID Interest Rounds, September 28, 2010
"Milwaukee protocol for human rabies and new perspectives for other CNS diseases", Pediatric Grand Rounds, Children's Hospital of Wisconsin, February 18, 2011
"Microbial Gas Warfare" [S. anginosus group meningitis] Combined Milwaukee Area ID Interest Rounds, October 25, 2011
"CNS infections" Pediatric Neurology Fellowship Lecture Series, February 17, 2012
"An 11 year old with obtundation" [West Nile Virus encephalitis] Combined Milwaukee Area ID Interest Rounds, January 22, 2013
"25 week gestation male born with a generalized rash" [Listeria monocytogenes] Combined Milwaukee Area ID Interest Rounds, March 25, 2014.
"Hydrogen sulfide as an inflammatory mediator and alternative uses of high dose hydroxycobalamin" Drug Repurposing Interest Platform (Drug Discovery Center, Depts of Pharmacology & Toxicology and Emergency Medicine) January 19, 2017
2004 - Present Member, Infection Control Committee
2004 - Present Member, Pharmacy and Therapeutics Committee
2010 - 2012 Whole Genome Sequencing Committee
1995 - 1996 Search Committee, Laboratory Director
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Yolken, R. H., WILLOUGHBY, R., Wee, S.B., Miskuff R., and Vonderfecht S.,: Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. J Clin Invest 79:148-154, 1987.
2. WILLOUGHBY, R.E., Wee, S.B., Yolken, R.H.,: Non-Group A rotavirus infection associated with severe gastroenteritis in a bone marrow transplant patient (case report). Pediatr Infect Dis J 7: 133-135, 1988.
3. Schwarz, K.B., Moore, T.J., WILLOUGHBY, R.E., Yolken, R.H.,: Hep-G2 cells support rotavirus (RV) infection. Hepatology 10[4]:646, 1989.
4. WILLOUGHBY, R.E., and Yolken, R.,: SA11 Rotavirus is specifically inhibited by an acetylated sialic acid. J Infect Dis 161:116 -119, 1990.
5. WILLOUGHBY, R.E., Yolken, R.H., and Schnaar, R.L.,: Rotaviruses specifically bind to the neutral glycosphingolipid asialo-GM1. J Virol 64: 4830-4835, 1990.
6. Schwarz, K.B., Moore, T.J., WILLOUGHBY, R.E., Siok-Bi, W., Vonderfecht, S.L., and Yolken, R.H.,: Growth of Group A rotaviruses in a human liver cell line. Hepatology 12: 638-643, 1991.
7. Wilde, J., Yolken, R., WILLOUGHBY, R., Eiden, J.,: Improved detection of rotavirus shedding by polymerase chain-reaction. Lancet 337:323-326, 1991.
8. Srnka, C.A., Tiemeyer, M., Gilbert, J.H., Moreland, M., Schweingruber, H., deLappe, B.W., James, P.G., Gand, T., WILLOUGHBY, R.E., Yolken, R.H., Nashed, M.A., Abbas, S.A., Laine, R.A.,: Cell Surface Ligands for Rotavirus: Mouse Intestinal Glycolipids and Synthetic Carbohydrate Analogs. Virology 190: 794-805, 1992.
9. Lindsay, D.A., Vonderfecht, S.S., WILLOUGHBY, R., Betenbaugh, M.J., and Eiden, J.J.,: Identification and expression of the outer capsid protein (VP4) of the IDIR strain of group B rotavirus (GBR). Virology 194: 724-733, 1993.
10. WILLOUGHBY, R.E.,: Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins. Glycobiology 5: 437-445, 1993.
11. Sicherer, S.H., Asturias, E.J., Winkelstein, J.A., Dick, J.D., WILLOUGHBY, R.E.,: Francisella philomiragia sepsis in chronic granulomatous disease. (case report) Pediatr Infect Dis J 16: 420 - 422, 1997.
12. Polack, F.P., Harrington, S.M., Winkelstein, J.A., Mertz, W.G., WILLOUGHBY, R.E.,: Recurrent Francisella philomiragia sepsis in chronic granulomatous disease. (case report) Pediatr Infect Dis J 17: 442-443, 1998.
13. WILLOUGHBY, R.E., and Polack, F.P.,: Meningitis in children. Contemporary Pediatrics 15: 49-70, 1998.
14. Reprinted subsequently in a sister publication: What's new in meningitis management. Patient Care 33: 237-254
15. Polack, F.P., Flayhart, D.C., Zahurak, M.L., Dick, J.D., WILLOUGHBY, R.E.,: Colonization by Streptococcus pneumoniae in human immunodeficiency virus-infected children. (Case-control study) Pediatr Infect Dis J 19: 608-12, 2000.
16. Hughes, W.T., Shenep, J.L., Rodman, J.H., Fridland, A., WILLOUGHBY, R., Blanchard, S., Purdue, L., Coakley, D.F., Cundy, K.C., Culnane, M., Zimmer, B., Burchett, S., Read, J.S., and the Pediatric AIDS Clinical Trials Group: Single dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil (bis-POM PMEA) in children with HIV-1 infection. Antimicrobial Agents & Chemotherapy 44: 1041-1046, 2000.
17. Arav-Boger, R., Baggett, H.C., Spevak, P.J., and WILLOUGHBY, R.E.,: Leukocytosis caused by prostaglandin E1 in neonates. (Case-control study) J Pediatrics 138: 263-265, 2000.
18. Lesko, S., O'Brien, K.L., Schwartz, B., Vezina, R., Mitchell, A.A.,: Invasive Group A streptococcal infection and nonsteroidal antiinflammatory drug use among children with primary varicella. (Network collaborator: REW, Johns Hopkins) Pediatrics 107:1108-1115, 2001.
19. Arav-Boger, R., WILLOUGHBY, R.E., Pass, R.F., Zong, J.C., Jang, W.J., Hayward, G.S.,: Polymorphisms of the cytomegalovirus-encoded TNF and -chemokine receptors in congenital CMV disease (case-control study). J Infect Dis 186:1057-1064, 2002.
20. Moss, W.J., Beers, M.C., Johnson, E., Nichols, D.G., Perl, T.M., Dick, J.D., Veltri, M.A., and WILLOUGHBY, R.E., JR.,: Pilot study of antibiotic cycling in a pediatric intensive care unit. Crit Care Med 2002; 30(8):1877-1882, 2002.
21. Grether, J.K., Nelson, K.B., Walsh, E., WILLOUGHBY, R.E., Redline, R.W.,: Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants (nested case-control study). Arch Pediatr Adolesc Med 157(1): 26-32, 2003.
22. Eschenbach D, Gravett M, WILLOUGHBY R.. Infectious diseases, preterm delivery, and infant outcomes. Emerg Infect Dis 2004; 10(11).
23. WILLOUGHBY R.E., Rotar MM, Dhonau HL, Ericksen KM, Capozzo DL, Kazmierczak JJ et al. Recovery of a patient from clinical rabies - Wisconsin, 2004. MMWR 2005; 53(50):1171-1173.
24. WILLOUGHBY R.E., JR., Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ et al. Survival after treatment of rabies with induction of coma. N Engl J Med 2005; 352(24):2508-2514.
25. WILLOUGHBY R.E., JR., Hammarin AL. Prophylaxis against rabies in children exposed to bats. Pediatr Infect Dis J 2005; 24(12):1109-1110.
26. Destino L, Sutton DA, Helon AL, Havens PL, Thometz JG, WILLOUGHBY R.E., JR. et al. Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury. Ann Clin Microbiol Antimicrob 2006; 5:21.
27. Christensen JC, Holm BM, Lechlitner S, Howell JF, Wenger M, Roy-Burman A [...] WILLOUGHBY R.E., Rupprecht, CE. Human rabies--Indiana and California, 2006. MMWR Morb Mortal Wkly Rep 2007; 56(15):361-365.
28. WILLOUGHBY R.E., Roy-Burman A, Martin KW, Christensen JC, Westenkirchner DF, Fleck JD et al. Generalized cranial artery spasm in human rabies. Developments in Biologicals. 2008; 131:367-375.
29. Johnstone J, Saxinger L, McDermid R, Bagshaw S, Resch L, Lee B ...[WILLOUGHBY R.E.] et al. Human Rabies -- Alberta, Canada, 2007. MMWR 2008; 57(8):1-4
30. WILLOUGHBY R.E., JR., Opladen T, Maier T, Rhead W, Schmiedel S, Hoyer J et al. Tetrahydrobiopterin deficiency in human rabies. J Inherit Metab Dis. 2008; 32:65-68.
31. Rubin J, David D, WILLOUGHBY RE, JR., Rupprecht CE, Garcia C, Guarda DC et al. Applying the Milwaukee Protocol to treat canine rabies in Equatorial Guinea. Scand J Infect Dis 2009; 41(5):372-375
32. Kumar S, Chusid MJ, WILLOUGHBY RE, Havens PL, Kehl SC et al. Introduction of a Novel Swine-Origin Influenza A (H1N1) Virus into Milwaukee, Wisconsin in 2009. Viruses 2009; 1(1) 72-83
33. WILLOUGHBY RE, JR. "Early death" and the contraindication of vaccine during treatment of rabies. Vaccine 2009; 27(51):7173-7177.
34. WILLOUGHBY RE, JR. Are we getting closer to the treatment of rabies? Future Virol 2009; 4(6):563-570.
35. Hunter M, Johnson N, Hedderwick S, McCaughey C, Lowry K, McConville J ...[WILLOUGHBY RE ]..et al. Immunovirological correlates in human rabies treated with therapeutic coma. J Med Virol 2010; 82(7):1255-1265.
36. Kumar S, Havens PL, Chusid MJ, WILLOUGHBY RE, JR., Simpson P, Henrickson KJ. Clinical and epidemiologic characteristics of children hospitalized with 2009 pandemic H1N1 influenza A infection. Pediatr Infect Dis J 2010; 29(7):591-594.
37. Kumar S, Chusid MJ, WILLOUGHBY RE, Havens PL, Kehl SC, Ledeboer NA et al. Epidemiologic Observations from Passive and Targeted Surveillance during the First Wave of the 2009 H1N1 Influenza Pandemic in Milwaukee, WI. Viruses 2010; 2(4):782-795.
38. Kumar S, Fan J, Melzer-Lange M, Trost J, Havens PL, Willoughby RE, et al. H1N1 Hemagglutinin-Inhibition Seroprevalence in Emergency Department Health Care Workers After the First Wave of the 2009 Influenza Pandemic. Pediatr Emerg Care 2011 Sep;27(9):804-7.
39. Aramburo A, Willoughby RE, Bollen AW, Glaser CA, Hsieh CJ, Davis SL, et al. Failure of the Milwaukee protocol in a child with rabies. Clin Infect Dis 2011 Sep;53(6):572-4.
40. Verma S, Landisch R, Quirk B, Schmainda K, Prah M, Whelan HT, et al [WILLOUGHBY RE] Presumed Hydrogen Sulfide-Mediated Neurotoxicity Following Streptococcus Anginosus Group Meningitis. Pediatr Infect Dis J 2012 Sep 25..
41. O'Sullivan A, WILLOUGHBY RE, Mishchuk D, Alcarraz B, Cabezas-Sanchez C, Condori RE, et al. Metabolomics of cerebrospinal fluid from humans treated for rabies. J Proteome Res 2013 Jan 4;12(1):481-90.
42. Caicedo Y, Paez A, Kuzmin I, Niezgoda M, Orciari LA, Yager PA, et al. [WILLOUGHBY RE] Virology, Immunology and Pathology of Human Rabies during Treatment. Pediatr Infect Dis J 2014 Nov 18.
43. Baltimore RS, Gewitz M, Baddour LM, Beerman LB, Jackson MA, Lockhart PB, et al. [WILLOUGHBY R.E., Jr.] Infective Endocarditis in Childhood: 2015 Update: A Scientific Statement From the American Heart Association. Circulation 2015 Sep 15.
44. Sannagowdara K, WILLOUGHBY R, Whelan H. Proton Nuclear Magnetic Resonance (NMR) Metabolomics: Future in Etiological Diagnosis of Encephalomyelitis. J Neuroinfect Dis 2015 Aug;6(3).
45. WILLOUGHBY RE, JR. Rabies: Rare Human Infection - Common Questions. Infect Dis Clin North Am 2015 Dec;29(4):637-50.
46. Petersen BW, Damon IK, Pertowski CA, Meaney-Delman D, Guarnizo JT, Beigi RH, et al. [WILLOUGHBY R.E., Jr.] Clinical guidance for smallpox vaccine use in a postevent vaccination program. MMWR Recomm Rep 2015 Feb 20;64(RR-02):1-26.
47. Lake JA, Ehrhardt MJ, Suchi M, Chun RH, WILLOUGHBY RE. A Case of Necrotizing Epiglottitis Due to Nontoxigenic Corynebacterium diphtheriae. Pediatrics 2015 Jul;136(1):e242-e245.
48. Zembles TN, Gaertner KM, Gutzeit MF, WILLOUGHBY RE. Implementation of American Academy of Pediatrics guidelines for palivizumab prophylaxis in a pediatric hospital. Am J Health Syst Pharm 2016 Mar 15;73(6):405-8.
49. Cohen R, Babushkin F, Shapiro M, Uda M, WILLOUGHBY RE, David D. Paralytic rabies misdiagnosed as Guillain-Barre syndrome in a guest
50. worker: a case Rreport. J Neuroinfect Dis 2016;7(1).
51. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. From the American Academy of Pediatrics: Policy statements--Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics 2009 Dec;124(6):1694-701.
52. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Policy statement--recommendations for the prevention and treatment of influenza in children, 2009 -2010. Pediatrics 2009 Oct;124(4):1216-26.
53. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Policy statement--Recommended childhood and adolescent immunization schedules--United States, 2010. Pediatrics 2010 Jan;125(1):195-6.
54. Rubin LG, Papsin B. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Cochlear implants in children: surgical site infections and prevention and treatment of acute otitis media and meningitis. Pediatrics 2010; 126(2):381-391.
55. Frankowski BL, Bocchini JA, Jr. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Head lice. Pediatrics 2010; 126(2):392-403.
56. Bernstein HH, Starke JR. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Policy statement--recommendation for mandatory influenza immunization of all health care personnel. Pediatrics 2010; 126(4):809-815.
57. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Policy statement--recommendations for prevention and control of influenza in children, 2010-2011. Pediatrics 2010; 126(4):816-826.
58. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Policy statement--Recommended childhood and adolescent immunization schedules--United States, 2010. Pediatrics 2010; 125(1):195-196.
59. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES Recommendations for the prevention of Streptococcus pneumoniae infections in infants and children: use of 13-valent pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV23). Pediatrics 2010; 126(1):186-190.
60. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Policy statement--recommended childhood and adolescent immunization schedules--United States, 2011. Pediatrics 2011 Feb;127(2):387-8.
61. **** AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Rabies-prevention policy update: new reduced-dose schedule. Pediatrics 2011 Apr;127(4):785-7.
62. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Recommendations for administering hepatitis A vaccine to contacts of international adoptees. Pediatrics 2011 Oct;128(4):803-4.
63. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Recommendations for prevention and control of influenza in children, 2011-2012. Pediatrics 2011 Oct;128(4):813-25.
64. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Poliovirus. Pediatrics 2011 Oct;128(4):805-8.
65. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Additional recommendations for use of tetanus toxoid, reduced-content diphtheria toxoid, and acellular pertussis vaccine (Tdap). Pediatrics 2011 Oct;128(4):809-12.
66. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Meningococcal conjugate vaccines policy update: booster dose recommendations. Pediatrics 2011 Dec;128(6):1213-8.
67. AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Recommended childhood and adolescent immunization schedules--United States, 2012. Pediatrics 2012 Feb;129(2):385-6.
68. **** AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. HPV vaccine recommendations. Pediatrics 2012 Mar;129(3):602-5.
69. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Recommended childhood and adolescent immunization schedules--United States, 2012. Pediatrics 2012 Feb;129(2):385-6.
70. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Recommendations for prevention and control of influenza in children, 2012-2013. Pediatrics 2012 Oct;130(4):780-92.
71. **** Schutze GE, WILLOUGHBY RE, AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON INFECTIOUS DISEASES. Clostridium difficile infection in infants and children. Pediatrics 2013 Jan;131(1):196-200.
72. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Recommended childhood and adolescent immunization schedule--United States, 2013. Pediatrics 2013 Feb;131(2):397-8
73. Kimberlin DW, Baley J, COMMITTEE ON INFECTIOUS DISEASES. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics 2013 Feb;131(2):383-6.
74. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Recommendations for prevention and control of influenza in children, 2013-2014. Pediatrics 2013 Oct;132(4):e1089-e1104.
75. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Consumption of raw or unpasteurized milk and milk products by pregnant women and children. Pediatrics 2014 Jan;133(1):175-9.
76. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Recommended childhood and adolescent immunization schedule--United States, 2014. Pediatrics 2014 Feb;133(2):357-63.
77. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics 2014 Aug;134(2):415-20.
78. AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Updated recommendations on the use of meningococcal vaccines. Pediatrics 2014 Aug;134(2):400-3.
79. Devore CD, Schutze GE, AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON INFECTIOUS DISEASES. Head lice. Pediatrics 2015 May;135(5):e1355-e1365.
80. NATIONAL VACCINE ADVISORY COMMITTEE. Overcoming Barriers to Low HPV Vaccine Uptake in the United States: Recommendations from the National Vaccine Advisory Committee: Approved by the National Vaccine Advisory Committee on June 9, 2015. Public Health Rep 2016 Jan;131(1):17-25.
81. Zembles TN, Gaertner KM, Gutzeit MF, Willoughby RE. Implementation of American Academy of Pediatrics guidelines for palivizumab prophylaxis in a pediatric hospital. Am J Health Syst Pharm. 2016 Mar 15;73(6):405-8.
82. Bick D, Fraser PC, Gutzeit MF, Harris JM, Hambuch TM, Helbling DC, Jacob HJ, Kersten JN, Leuthner SR, May T, North PE, Prisco SZ, Schuler BA, Shimoyama M, Strong KA, Van Why SK, Veith R, Verbsky J, Weborg AM Jr, Wilk BM, Willoughby RE Jr, Worthey EA, Dimmock DP. Successful Application of Whole Genome Sequencing in a Medical Genetics Clinic. J Pediatr Genet. 2017 Jun;6(2):61-76. PMCID: PMC5423809
83. French CD, Willoughby RE, Pan A, Wong SJ, Foley JF, Wheat LJ, Fernandez J, Encarnacion R, Ondrush JM, Fatteh N, Paez A, David D, Javaid W, Amzuta IG, Neilan AM, Robbins GK, Brunner AM, Hu WT, Mishchuk DO, Slupsky CM. NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system. PLoS Negl Trop Dis. 2018 Dec;12(12):e0007045. PMCID: PMC6312347
84. Zembles TN, Bushee GM, Willoughby RE. Impact of American Academy of Pediatrics Palivizumab Guidance for Children ≥29 and <35 Weeks of Gestational Age. J Pediatr. 2019 Jun;209:125-129.
85. Patel JJ, Venegas-Borsellino C, Willoughby R, Freed JK. High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review. Nutr Clin Pract. 2019 Aug;34(4):514-520.
86. Hall JM, Havens PL, Mitchell EA, De Vela GN, Titus LL, Dasgupta M, Simpson PM, Kehl SC, Willoughby RE, Henrickson KJ, Mitchell ML, Huppler AR, Chusid MJ. Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. Pediatr Infect Dis J. 2021 Sep 01;40(9):802-807.
87. Taylor E, Aguilar-Ancori EG, Banyard AC, Abel I, Mantini-Briggs C, Briggs CL, Carrillo C, Gavidia CM, Castillo-Neyra R, Parola AD, Villena FE, Prada JM, Petersen BW, Falcon Perez N, Cabezas Sanchez C, Sihuincha M, Streicker DG, Maguina Vargas C, Navarro Vela AM, Vigilato MAN, Wen Fan H, Willoughby R, Horton DL, Recuenco SE. The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era. Int Health. 2023 Mar 01;15(2):216-223. PMCID: PMC9384559
88. Patel JJ, Willoughby R, Peterson J, Carver T, Zelten J, Markiewicz A, Spiegelhoff K, Hipp LA, Canales B, Szabo A, Heyland DK, Stoppe C, Zielonka J, Freed JK. High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial). Chest. 2023 Feb;163(2):303-312.
89. Baker HJ, Martin DR, Gross AL, Chamorro MF, Naskou MC, Johnson AK, Brock KV, Van Kampen KR, Willoughby RE. Rabies: who should care? J Am Vet Med Assoc. 2022 Dec 07;261(4):592-596.
90. Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ. Collagen-Specific HSP47<sup>+</sup> Myofibroblasts and CD163<sup>+</sup> Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. J Am Heart Assoc. 2023 Feb 21;12(4):e027990. PMCID: PMC10111490
91. Liu Y, Mo X, Feng Y, Willoughby RE, Weng X, Wang Y, Li X, Gao J, Tian J, Peng J. Metagenomic next-generation sequencing for the etiological diagnosis of rabies virus in cerebrospinal fluid. Front Med (Lausanne). 2023;10:982290. PMCID: PMC9947348
92. Ahmed G, Abdelgadir Y, Abdelghani A, Simpson P, Barbeau J, Basel D, Barrios CS, Smith BA, Schilter KF, Udani R, Reddi HV, Willoughby RE. Reduction in ACE2 expression in peripheral blood mononuclear cells during COVID-19 - implications for post COVID-19 conditions. BMC Infect Dis. 2024 Jul 03;24(1):663. PMCID: PMC11221185
93. Edwards KM, Hackell JM, COMMITTEE ON INFECTIOUS DISEASES, THE COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE. Countering Vaccine Hesitancy. Pediatrics. 2016 Sep;138(3).
94. Yolken RH, Willoughby R, Wee SB, Miskuff R, Vonderfecht S. Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses Journal of Clinical Investigation. 1987;79(1):148-154.
95. Willoughby RE, Wee SB, Yolken RH. Non-group A rotavirus infection associated with severe gastroenteritis in a bone marrow transplant patient. Pediatr Infect Dis J. 1988 Feb;7(2):133-5.
96. Willoughby RE, Yolken RH. SA11 rotavirus is specifically inhibited by an acetylated sialic acid. J Infect Dis. 1990 Jan;161(1):116-9.
97. Schwarz KB, Moore TJ, Willoughby RE Jr, Wee SB, Vonderfecht SL, Yolken RH. Growth of group A rotaviruses in a human liver cell line. Hepatology. 1990 Oct;12(4 Pt 1):638-43.
98. Willoughby RE, Yolken RH, Schnaar RL. Rotaviruses specifically bind to the neutral glycosphingolipid asialo-GM1. J Virol. 1990 Oct;64(10):4830-5. PMCID: PMC247971
99. Yolken R, Kinney J, Wilde J, Willoughby R, Eiden J. Immunoglobulins and other modalities for the prevention and treatment of enteric viral infections. J Clin Immunol. 1990 Nov;10(6 Suppl):80S-86S; discussion 86S-87S.
100. Wilde J, Yolken R, Willoughby R, Eiden J. Improved detection of rotavirus shedding by polymerase chain reaction. Lancet. 1991 Feb 09;337(8737):323-6.
101. Srnka CA, Tiemeyer M, Gilbert JH, Moreland M, Schweingruber H, de Lappe BW, James PG, Gant T, Willoughby RE, Yolken RH. Cell surface ligands for rotavirus: mouse intestinal glycolipids and synthetic carbohydrate analogs. Virology. 1992 Oct;190(2):794-805.
102. Lindsay DA, Vonderfecht SS, Willoughby R, Betenbaugh MJ, Eiden JJ. Identification and expression of the outer capsid protein (vp4) of the idir strain of group b rotavirus Virology. 1993;194(2):724-733.
103. Willoughby RE. Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins. Glycobiology. 1993 Oct;3(5):437-45.
104. Sicherer SH, Asturias EJ, Winkelstein JA, Dick JD, Willoughby RE. Francisella philomiragia sepsis in chronic granulomatous disease. Pediatr Infect Dis J. 1997 Apr;16(4):420-2.
105. . Synthetic polymers rescue infants from disease in the murine rotavirus model Clinical Infectious Diseases. 1997;25(2):488.
106. Willoughby RE, Kurtz C, Marquez ML, Garigapati V, Pitruzzello M, Neenan TX. Synthetic polymers rescue infants from disease in the murine rotavirus model Clinical Infectious Diseases. 1997;25(2):488.
107. Polack FP, Harrington SM, Winkelstein JA, Merz WG, Willoughby RE. Recurrent Francisella philomiragia sepsis in chronic granulomatous disease. Pediatr Infect Dis J. 1998 May;17(5):442-3.
108. Willoughby RE, Polack FS. What's new in meningitis management Patient Care. 15 June 1999;33(11):237-254.
109. Hughes WT, Shenep JL, Rodman JH, Fridland A, Willoughby R, Blanchard S, Purdue L, Coakley DF, Cundy KC, Culnane M, Zimmer B, Burchett S, Read JS. Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group. Antimicrob Agents Chemother. 2000 Apr;44(4):1041-6. PMCID: PMC89810
110. Polack FP, Flayhart DC, Zahurak ML, Dick JD, Willoughby RE. Colonization by Streptococcus penumoniae in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 2000 Jul;19(7):608-12.
111. Arav-Boger R, Baggett HC, Spevak PJ, Willoughby RE. Leukocytosis caused by prostaglandin E1 in neonates. J Pediatr. 2001 Feb;138(2):263-5.
112. Moss WJ, Beers MC, Johnson E, Nichols DG, Perl TM, Dick JD, Veltri MA, Willoughby RE Jr. Pilot study of antibiotic cycling in a pediatric intensive care unit. Crit Care Med. 2002 Aug;30(8):1877-82.
113. Arav-Boger R, Willoughby RE, Pass RF, Zong JC, Jang WJ, Alcendor D, Hayward GS. Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease. J Infect Dis. 2002 Oct 15;186(8):1057-64.
114. Grether JK, Nelson KB, Walsh E, Willoughby RE, Redline RW. Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med. 2003 Jan;157(1):26-32.
115. Willoughby RE Jr, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE. Survival after treatment of rabies with induction of coma. N Engl J Med. 2005 Jun 16;352(24):2508-14.
116. Willoughby RE Jr, Hammarin AL. Prophylaxis against rabies in children exposed to bats. Pediatr Infect Dis J. 2005 Dec;24(12):1109-10.
117. Destino L, Sutton DA, Helon AL, Havens PL, Thometz JG, Willoughby RE Jr, Chusid MJ. Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury. Ann Clin Microbiol Antimicrob. 2006 Sep 08;5:21. PMCID: PMC1592504
118. Centers for Disease Control and Prevention (CDC). Human rabies--Indiana and California, 2006. MMWR Morb Mortal Wkly Rep. 2007 Apr 20;56(15):361-5.
119. Hu WT, Willoughby RE Jr, Dhonau H, Mack KJ. Long-term follow-up after treatment of rabies by induction of coma. N Engl J Med. 2007 Aug 30;357(9):945-6.
120. Centers for Disease Control and Prevention (CDC). Human rabies--Alberta, Canada, 2007. MMWR Morb Mortal Wkly Rep. 2008 Feb 29;57(8):197-200.
121. Willoughby RE, Roy-Burman A, Martin KW, Christensen JC, Westenkirschner DF, Fleck JD, Glaser C, Hyland K, Rupprecht CE. Generalised cranial artery spasm in human rabies. Dev Biol (Basel). 2008;131:367-75.
122. Willoughby RE, Opladen T, Maier T, Rhead W, Schmiedel S, Hoyer J, Drosten C, Rupprecht CE, Hyland K, Hoffmann GF. Tetrahydrobiopterin deficiency in human rabies. J Inherit Metab Dis. 2009 Feb;32(1):65-72.
123. Willoughby RE, Long SS. Encephalitis, Meningoencephalitis, Acute Disseminated Encephalomyelitis, and Acute Necrotizing Encephalopathy Principles and Practice of Pediatric Infectious Disease Third Edition. 1 January 2009:310-318.
124. Rubin J, David D, Willoughby RE Jr, Rupprecht CE, Garcia C, Guarda DC, Zohar Z, Stamler A. Applying the Milwaukee protocol to treat canine rabies in Equatorial Guinea. Scand J Infect Dis. 2009;41(5):372-5.
125. Committee on Infectious Diseases. Policy statement--recommendations for the prevention and treatment of influenza in children, 2009 -2010. Pediatrics. 2009 Oct;124(4):1216-26.
126. Committee on Infectious Diseases. From the American Academy of Pediatrics: Policy statements--Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics. 2009 Dec;124(6):1694-701.
127. Kumar S, Chusid MJ, Willoughby RE, Havens PL, Kehl SC, Ledeboer NA, Li SH, Henrickson KJ. Introduction of a Novel Swine-Origin Influenza A (H1N1) Virus into Milwaukee, Wisconsin in 2009. Viruses. 2009 Jun 01;1(1):72-83. PMCID: PMC2768288
128. Willoughby RE Jr. "Early death" and the contraindication of vaccine during treatment of rabies. Vaccine. 2009 Nov 27;27(51):7173-7.
129. Willoughby RE. Are we getting closer to the treatment of rabies? Future Virology. 2009;4(6):563-570.
130. Committee on Infectious Diseases. Policy statement--Recommended childhood and adolescent immunization schedules--United States, 2010. Pediatrics. 2010 Jan;125(1):195-6.
131. American Academy of Pediatrics Committee on Infectious Diseases. Recommendations for the prevention of Streptococcus pneumoniae infections in infants and children: use of 13-valent pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV23). Pediatrics. 2010 Jul;126(1):186-90.
132. Hunter M, Johnson N, Hedderwick S, McCaughey C, Lowry K, McConville J, Herron B, McQuaid S, Marston D, Goddard T, Harkess G, Goharriz H, Voller K, Solomon T, Willoughby RE, Fooks AR. Immunovirological correlates in human rabies treated with therapeutic coma. J Med Virol. 2010 Jul;82(7):1255-65.
133. Kumar S, Havens PL, Chusid MJ, Willoughby RE Jr, Simpson P, Henrickson KJ. Clinical and epidemiologic characteristics of children hospitalized with 2009 pandemic H1N1 influenza A infection. Pediatr Infect Dis J. 2010 Jul;29(7):591-4.
134. Kumar S, Chusid MJ, Willoughby RE, Havens PL, Kehl SC, Ledeboer NA, Simpson P, Vandyke M, Davis E, Gaffney K, Li SH, Bose ME, Henrickson KJ. Epidemiologic Observations from Passive and Targeted Surveillance during the First Wave of the 2009 H1N1 Influenza Pandemic in Milwaukee, WI. Viruses. 2010;2(4):782-795. PMCID: PMC2905828
135. Frankowski BL, Bocchini JA Jr, Council on School Health and Committee on Infectious Diseases. Head lice. Pediatrics. 2010 Aug;126(2):392-403.
136. American Academy of Pediatrics. Committee on Infectious Diseases. Policy statement--recommendations for prevention and control of influenza in children, 2010-2011. Pediatrics. 2010 Oct;126(4):816-26.
137. Bernstein HH, Starke JR, American Academy of Pediatrics. Committee on Infectious Diseases. Policy statement--recommendation for mandatory influenza immunization of all health care personnel. Pediatrics. 2010 Oct;126(4):809-15.
138. Committee on Infectious Diseases, American Academy of Pediatrics. Policy statement--recommended childhood and adolescent immunization schedules--United States, 2011. Pediatrics. 2011 Feb;127(2):387-8.
139. Committee on Infectious Diseases. Rabies-prevention policy update: new reduced-dose schedule. Pediatrics. 2011 Apr;127(4):785-7.
140. Committee on Infectious Diseases, Committee on Fetus and Newborn, Baker CJ, Byington CL, Polin RA. Policy statement—Recommendations for the prevention of perinatal group B streptococcal (GBS) disease. Pediatrics. 2011 Sep;128(3):611-6.
141. Aramburo A, Willoughby RE, Bollen AW, Glaser CA, Hsieh CJ, Davis SL, Martin KW, Roy-Burman A. Failure of the Milwaukee protocol in a child with rabies. Clin Infect Dis. 2011 Sep;53(6):572-4.
142. Committee on Infectious Diseases. Policy statement—Prevention of varicella: update of recommendations for use of quadrivalent and monovalent varicella vaccines in children. Pediatrics. 2011 Sep;128(3):630-2.
143. Kumar S, Fan J, Melzer-Lange M, Trost J, Havens PL, Willoughby RE, Chusid MJ, Henrickson KJ. H1N1 hemagglutinin-inhibition seroprevalence in Emergency Department Health Care workers after the first wave of the 2009 influenza pandemic. Pediatr Emerg Care. 2011 Sep;27(9):804-7.
144. American Academy of Pediatrics Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2011-2012. Pediatrics. 2011 Oct;128(4):813-25.
145. American Academy of Pediatrics Committee on Infectious Diseases. Poliovirus. Pediatrics. 2011 Oct;128(4):805-8.
146. Bradley JS, Jackson MA, Committee on Infectious Diseases, American Academy of Pediatrics. The use of systemic and topical fluoroquinolones. Pediatrics. 2011 Oct;128(4):e1034-45.
147. Centers for Disease Control and Prevention, American Academy of Pediatrics Committee on Infectious Diseases. Additional recommendations for use of tetanus toxoid, reduced-content diphtheria toxoid, and acellular pertussis vaccine (Tdap). Pediatrics. 2011 Oct;128(4):809-12.
148. Committee on Infectious Diseases. Meningococcal conjugate vaccines policy update: booster dose recommendations. Pediatrics. 2011 Dec;128(6):1213-8.
149. Lessin HR, Edwards KM, Committee On Practice And Ambulatory Medicine, Committee On Infectious Diseases. Immunizing parents and other close family contacts in the pediatric office setting. Pediatrics. 2012 Jan;129(1):e247-53.
150. COMMITTEE ON INFECTIOUS DISEASES. Recommended childhood and adolescent immunization schedules--United States, 2012. Pediatrics. 2012 Feb;129(2):385-6.
151. Committee on Infectious Diseases. HPV vaccine recommendations. Pediatrics. 2012 Mar;129(3):602-5.
152. Polin RA, Denson S, Brady MT, Committee on Fetus and Newborn, Committee on Infectious Diseases. Epidemiology and diagnosis of health care-associated infections in the NICU. Pediatrics. 2012 Apr;129(4):e1104-9.
153. Polin RA, Denson S, Brady MT, Committee on Fetus and Newborn, Committee on Infectious Diseases. Strategies for prevention of health care-associated infections in the NICU. Pediatrics. 2012 Apr;129(4):e1085-93.
154. Centers for Disease Control and Prevention (CDC). Imported human rabies in a U.S. Army soldier - New York, 2011. MMWR Morb Mortal Wkly Rep. 2012 May 04;61(17):302-5.
155. Committee on Infectious Diseases, American Academy of Pediatrics. Recommendations for prevention and control of influenza in children, 2012-2013. Pediatrics. 2012 Oct;130(4):780-92.
156. Verma S, Landisch R, Quirk B, Schmainda K, Prah M, Whelan HT, Willoughby RE Jr. Presumed hydrogen sulfide-mediated neurotoxicity after streptococcus anginosus group meningitis. Pediatr Infect Dis J. 2013 Feb;32(2):189-91. PMCID: PMC3548939
157. O'Sullivan A, Willoughby RE, Mishchuk D, Alcarraz B, Cabezas-Sanchez C, Condori RE, David D, Encarnacion R, Fatteh N, Fernandez J, Franka R, Hedderwick S, McCaughey C, Ondrush J, Paez-Martinez A, Rupprecht C, Velasco-Villa A, Slupsky CM. Metabolomics of cerebrospinal fluid from humans treated for rabies. J Proteome Res. 2013 Jan 04;12(1):481-90. PMCID: PMC4824192
158. Schutze GE, Willoughby RE, Committee on Infectious Diseases, American Academy of Pediatrics. Clostridium difficile infection in infants and children. Pediatrics. 2013 Jan;131(1):196-200.
159. Committee on infectious diseases. Recommendations for prevention and control of influenza in children, 2013-2014. Pediatrics. 2013 Oct;132(4):e1089-104.
160. Maldonado YA, Glode MP, Bhatia J, Brady MT, Byington CL, Davies HD, Edwards KM, Jackson MA, Keyserling HL, Murray DL, Orenstein WA, Schutze GE, Willoughby RE, Zaoutis TE, Bhatia JJS, Abrams SA, Corkins MR, De Ferranti SD, Golden NH, Magge SN, Schwarzenberg SJ. Consumption of raw or unpasteurized milk and milk products by pregnant women and children Pediatrics. January 2014;133(1):175-179.
161. Committee on Infectious Diseases, American Academy of Pediatrics. Recommended childhood and adolescent immunization schedule--United States, 2014. Pediatrics. 2014 Feb;133(2):357-63.
162. Bradley JS, Peacock G, Krug SE, Bower WA, Cohn AC, Meaney-Delman D, Pavia AT, AAP Committee on Infectious Diseases and Disaster Preparedness Advisory Council. Pediatric anthrax clinical management. Pediatrics. 2014 May;133(5):e1411-36. PMCID: PMC4479255
163. American Academy of Pediatrics Committee on Infectious Diseases, American Academy of Pediatrics Bronchiolitis Guidelines Committee. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics. 2014 Aug;134(2):e620-38.
164. American Academy of Pediatrics Committee on Infectious Diseases. Updated recommendations on the use of meningococcal vaccines. Pediatrics. 2014 Aug;134(2):400-3.
165. Committee On Infectious Diseases, American Academy Pediatrics. Recommendations for prevention and control of influenza in children, 2014-2015. Pediatrics. 2014 Nov;134(5):e1503-19.
166. Caicedo Y, Paez A, Kuzmin I, Niezgoda M, Orciari LA, Yager PA, Recuenco S, Franka R, Velasco-Villa A, Willoughby RE Jr. Virology, immunology and pathology of human rabies during treatment. Pediatr Infect Dis J. 2015 May;34(5):520-8. PMCID: PMC4809748
167. Starke JR, Committee On Infectious Diseases. Interferon-γ release assays for diagnosis of tuberculosis infection and disease in children. Pediatrics. 2014 Dec;134(6):e1763-73.
168. Committee On Infectious Diseases. Immunization for Streptococcus pneumoniae infections in high-risk children. Pediatrics. 2014 Dec;134(6):1230-3.
169. Orenstein WA, Committee on Infectious Diseases. Eradicating polio: how the world's pediatricians can help stop this crippling illness forever. Pediatrics. 2015 Jan;135(1):196-202.
170. Petersen BW, Damon IK, Pertowski CA, Meaney-Delman D, Guarnizo JT, Beigi RH, Edwards KM, Fisher MC, Frey SE, Lynfield R, Willoughby RE. Clinical guidance for smallpox vaccine use in a postevent vaccination program. MMWR Recomm Rep. 2015 Feb 20;64(RR-02):1-26.
171. Devore CD, Schutze GE, Council on School Health and Committee on Infectious Diseases, American Academy of Pediatrics. Head lice. Pediatrics. 2015 May;135(5):e1355-65.
172. Lake JA, Ehrhardt MJ, Suchi M, Chun RH, Willoughby RE. A Case of Necrotizing Epiglottitis Due to Nontoxigenic Corynebacterium diphtheriae. Pediatrics. 2015 Jul;136(1):e242-5.
173. Baltimore RS, Gewitz M, Baddour LM, Beerman LB, Jackson MA, Lockhart PB, Pahl E, Schutze GE, Shulman ST, Willoughby R Jr, American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young and the Council on Cardiovascular and Stroke Nursing. Infective Endocarditis in Childhood: 2015 Update: A Scientific Statement From the American Heart Association. Circulation. 2015 Oct 13;132(15):1487-515.
174. National Vaccine Advisory Committee. Overcoming Barriers to Low HPV Vaccine Uptake in the United States: Recommendations from the National Vaccine Advisory Committee: Approved by the National Vaccine Advisory Committee on June 9, 2015. Public Health Rep. 2016;131(1):17-25. PMCID: PMC4716467
 
Books, Chapters, and Reviews
1. Kelly, K., and WILOUGHBY, R.E.,: Milk intolerance, eosinophilic enteritis, noninflammatory diarrhea in infants. In S.S. Long, C.G. Prober and L.K. Pickering (eds.) Principles and Practice of Pediatric Infectious Diseases, Churchill Livingstone, 1996.
2. WILLOUGHBY, R.E.,: Necrotizing enteritis. In S.S. Long, C.G. Prober and L.K. Pickering (eds.) Principles and Practice of Pediatric Infectious Diseases, Churchill Livingstone, 1996.
3. WILLOUGHBY, R.E.,: Transverse myelitis and myelopathy, neuritis and neuropathy, Guillain Barre syndrome, cerebellar ataxia. In S.S. Long, C.G. Prober and L.K. Pickering (eds.) Principles and Practice of Pediatric Infectious Diseases, Churchill Livingstone, 1996.
4. WILLOUGHBY, R.E.,: Encephalitis, meningoencephalitis and post-infectious encephalitis. In S.S. Long, C.G. Prober and L.K. Pickering (eds.) Principles and Practice of Pediatric Infectious Diseases, Churchill Livingstone, 1996.
5. Berkowitz, I.D., Berkowitz, F.E., Newton, C., WILLOUGHBY, R., and Ackerman, A.D.,: Meningitis, Infectious Encephalopathies, and Other Central Nervous System Infections. In M. Rogers and D. Nichols (eds.) Textbook of Pediatric Intensive Care, Williams and Wilkins, 1996.
6. reprinted subsequently in abridged form: In M.D. Rogers and M.A. Helfaer (eds.) Handbook of Pediatric Intensive Care, Williams and Wilkins, 1999.
7. WILLOUGHBY, R.E., and Asturias, E.J.,: Postinfectious and vaccine-related encephalitis. In D. Armstrong and J. Cohen (eds.) Infectious Diseases, Mosby, Ch. 20, 1-8, 1999.
8. WILLOUGHBY, R.E.: Transverse myelitis and myelopathy, neuritis and neuropathy, Guillain Barre syndrome, cerebellar ataxia. In S.S. Long, C.G. Prober and L.K. Pickering (eds.) Principles and Practice of Pediatrics Infectious Diseases, 2nd edition, Churchill Livingstone, Ch. 46, 296-302, 2003.
9. WILLOUGHBY, R.E.: Encephalitis, meningoencephalitis, and post-infectious encephalitis. In S.S. Long, C.G. Prober, and L.K. Pickering (eds.) Principles and Practice of Pediatric Infectious Diseases, 2nd edition, Churchill Livingstone, Ch. 45, 291-296, 2003.
10. ACOG Task Force on Neonatal Encephalopathy and Cerebral Palsy - defining the pathogenesis and pathophysiology. American College of Obstetricians and Gynecologists and American Academy of Pediatrics, January, 2003 (RODNEY E. WILLOUGHBY, LISTED CONSULTANT).
11. Asturias, E.J., and WILLOUGHBY, R.W.: Postinfectious and vaccine-related encephalitis. In J. Cohen and W.G. Powderly (eds.) Infectious Diseases, Mosby, Ch 27, 307-315, 20004.
12. Rupprecht CE, WILLOUGHBY R., Slate D. Current and future trends in the prevention, treatment and control of rabies. Expert Rev Anti Infect Ther 2006; 4(6):1021-1038.
13. WILLOUGHBY R.E., JR. Cerebellar ataxia, transverse myelitis and myelopathy, Guillain-Barré syndrome, neuritis, and neuropathy. In: Long SS, Pickering LK, Prober CG, editors. Principles and practice of pediatric infectious diseases. New York: Churchill Livingstone, 2008: 318-324.
14. WILLOUGHBY RE, JR. Rabies virus. In: Long SS, Pickering LK, Prober CG, editors. Principles and practice of pediatric infectious diseases. New York: Churchill Livingstone, 2008.
15. WILLOUGHBY RE, JR., Long SS. Encephalitis, meningoencephalitis, acute disseminated encephalomyelitis, and acute necrotizing encephalopathy. In: Long SS, Pickering LK, Prober CG, editors. Principles and practice of pediatric infectious diseases. New York: Churchill Livingstone, 2008.
16. WILLOUGHBY RE, JR. Rabies. In: Kliegman RM, Stanton BF, St. Geme J, Schor N, Behrman RE, editors. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: Elsevier, 2011
17. COMMITTEE ON INFECTIOUS DISEASES, AMERICAN ACADEMY OF PEDIATRICS. Red Book: 2012 Report of the Committee on Infectious Diseases (29th edition). Elk Grove Village IL, American Academy of Pediatrics Press, 2012
18. COMMITTEE ON INFECTIOUS DISEASES, AMERICAN ACADEMY OF PEDIATRICS. Red Book: 2015 Report of the Committee on Infectious Diseases (30th edition). Elk Grove Village IL, American Academy of Pediatrics Press, 2015
19. WILLOUGHBY RE, JR. Rabies: Rare Human Infection - Common Questions. Infect Dis Clin North Am 2015 Sep 15.
20. WILLOUGHBY R, JR. Rabies. In: Kliegman RM, Stanton BF, St.Geme III JW, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 20 ed. Elsevier; 2016. p. 1641-3.
21. Recuenco S, WILLOUGHBY R. Rabies. BMJ Best Practice.
22. Willoughby RE. Rabies Virus Principles and Practice of Pediatric Infectious Diseases. 2018:1176-1181.e1.
23. Wilson PJ, Rohde RE, Oriertli E, Willoughby RE. Rabies: Clinical Considerations and Exposure Evaluations Rabies Clinical Considerations and Exposure Evaluations. 1 January 2019:1-146.
24. Willoughby RE. Rabies Virus Principles and Practice of Pediatric Infectious Diseases. 1 January 2022:1201-1204.e1.
25. Willoughby RE. Rabies Nelson Textbook of Pediatrics Volume 1 2. 1 January 2024:2081-2084.e1.
26. Willoughby RE Jr, Pickering LK. Necrotizing enterocolitis and infection. Clin Perinatol. 1994 Jun;21(2):307-15. PMCID: PMC7133271
27. Willoughby RE, Livingston RA. Approach to the HIV-infected child with diarrhea Seminars in Pediatric Infectious Diseases. January 1995;6(1):17-25.
28. Nelson KB, Willoughby RE. Infection, inflammation and the risk of cerebral palsy. Curr Opin Neurol. 2000 Apr;13(2):133-9.
29. Nelson KB, Willoughby RE. Overview: infection during pregnancy and neurologic outcome in the child. Ment Retard Dev Disabil Res Rev. 2002;8(1):1-2.
30. Willoughby RE Jr, Nelson KB. Chorioamnionitis and brain injury. Clin Perinatol. 2002 Dec;29(4):603-21.
31. Rupprecht CE, Willoughby R, Slate D. Current and future trends in the prevention, treatment and control of rabies. Expert Rev Anti Infect Ther. 2006 Dec;4(6):1021-38.
32. Willoughby RE Jr. A cure for a rabies? Sci Am. 2007 Apr;296(4):88-95.
33. Willoughby RE. Rabies Virus Principles and Practice of Pediatric Infectious Disease Third Edition. 1 January 2009:1126-1130.
34. Willoughby RE. Cerebellar Ataxia, Transverse Myelitis and Myelopathy, Guillain–Barré Syndrome, Neuritis, and Neuropathy Principles and Practice of Pediatric Infectious Disease Third Edition. 1 January 2009:318-324.
35. Willoughby RE. Rabies Virus Principles and Practice of Pediatric Infectious Diseases Fourth Edition. 1 January 2012:1145-1149.e2.
36. Willoughby RE Jr. Rabies: Rare Human Infection - Common Questions. Infect Dis Clin North Am. 2015 Dec;29(4):637-50.
 
Editorials, Letters To Editor, Other
1. WILLOUGHBY, R.E.,: Maternal infections are depressing. Pediatrics 110:832-833, 2002.
2. WILLOUGHBY RE, JR. Beware observational studies in neonatal practice. Arch Pediatr Adolesc Med 2003,157(9):934-935
3. Kliegman RM, WILLOUGHBY RE. Prevention of necrotizing enterocolitis with probiotics. Pediatrics 2005; 115(1):171-172
4. Hu WT, WILLOUGHBY RE, Jr., Dhonau H, Mack KJ. Long-term follow-up after treatment of rabies by induction of coma. N Engl J Med 2007; 357(9):945-946.
5. WILLOUGHBY RE, Opladen T. Serum phenylalanine concentrations in patients post trauma and burn correlate to neopterin concentrations -- author reply. J Inherit Metab Dis 2009; 32(4):588.
6. WILLOUGHBY RE, JR. Resistance to rabies. Am J Trop Med Hyg 2012 Aug;87(2):205
7. Zembles TN, Bushee G, Willoughby RE. Reply. J Pediatr. 2019 Sep;212:247-248.
8. Willoughby R. Aging and Rabies Prophylaxis. Clin Infect Dis. 2023 Sep 18;77(6):931.
9. Willoughby RE. Premature Demise of the Milwaukee Protocol. Clin Infect Dis. 2025 Dec 24;81(5):e467-e468.
10. Willoughby RE Jr. Maternal infections are depressing. Pediatrics. 2002 Oct;110(4):832-3.
11. Willoughby RE Jr. Beware observational studies in neonatal practice. Arch Pediatr Adolesc Med. 2003 Sep;157(9):934-5; author reply 935.
12. Kliegman RM, Willoughby RE. Prevention of necrotizing enterocolitis with probiotics. Pediatrics. 2005 Jan;115(1):171-2.
13. Hemachudha T, Wilde H. Survival after treatment of rabies. N Engl J Med. 2005 Sep 08;353(10):1068-9; author reply 1068-9.
14. Willoughby RE, Opladen T. Response from Willoughby and Opladen Journal of Inherited Metabolic Disease. 2009;32(4):588.
15. Willoughby RE. Resistance to rabies. Am J Trop Med Hyg. 2012 Aug;87(2):205. PMCID: PMC3414553
 
Non-Refereed Journal Publications/Original Papers
1. Yolken, R., Kinney, J., Wilde, J., WILLOUGHBY, R., and Eiden, J. Immunoglobulins and other modalities for the prevention and treatment of enteric viral infections. J Clin Immunol 10:80S-87S, 1990.
2. WILLOUGHBY, R.E., and Pickering L.K.,: Necrotizing enterocolitis and infection. Clin Perinatol 21:307-316, 1994.
3. WILLOUGHBY, R.E., and Livingstone, R.A. Approach to the HIV-infected child with diarrhea. Semin Pediatr Infect Dis 6:17-25, 1995.
4. Nelson, K.B., WILLOUGHBY, R.E.,: Infection, inflammation, and risk of cerebral palsy. Current Opinion in Neurology 13:133-139, 2000.
5. WILLOUGHBY, R.E., and Nelson, K.B.,: Overview: infection during pregnancy and neurologic outcome in the child. Mental Retard Dev Dis Res Rev 8:1-2, 2002.
6. WILLOUGHBY, R.E., JR., and Nelson, K.B.,: Chorioamnionitis and brain injury. Clin Pernatol 29:603-621, 2002.
7. WILLOUGHBY R.E., JR. A cure for a rabies? Sci Am 2007; 296(4):88-95
8. Republished in compendium: Infectious Disease: A Scientific American Reader. 2008. University of Chicago Press
9. WILLOUGHBY, R.E., Schnaar R., Yolken, R.H. Rotaviruses and other enteric viruses specifically bind to asialo GM1 (GA1). Pediatric Research 25[4]:A193.
10. Schwarz, K.B., Moore, T.J., WILLOUGHBY, R.E., Yolken, R.H. Growth of rotaviruses in a human-liver cell-line. Pediatric Research 25[4]:A124, 1989.
11. WILLOUGHBY, R.E., Hart, G., Yolken, R.,: Rotavirus VP7 determines expression of VP4-mediated hamagglutination and sialic-acid dependent replication. Pediatric Research 27[4], A187
12. WILLOUGHBY, R.E., Hart, G.W., Yolken, R.H.,: Simian rotaviruses recognize distinct classes of glycolipids and glycoproteins. Pediatric Research 29[4], A189, 1991.
13. WILLOUGHBY RE, JR., Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ et al. Survival from rabies through improvised use of a therapeutic coma. XVI International Conference on Rabies in the Americas, Ottawa, Ontario, Canada, October 16-21, 2005 .
14. WILLOUGHBY R.E., Maier T, Rupprecht CE, Rhead WJ, Hyland K, Hoffmann GF et al. Biopterin deficiency in human rabies. XVII International Conference on Rabies in the Americas, Brasilia, Brazil, October 15-22, 2006
15. WILLOUGHBY R.E., Hayes J, Sather S, Medina B, Overholt P. Web-based rabies treatment registry with downloadable protocol [www.chw.org/rabies]. XVII International Conference on Rabies in the Americas, Brasilia, Brazil, October 15-22, 2006 .
16. WILLOUGHBY R.E., Roy-Burman A, Martin KW, Christensen JC, Westenkirchner DF, Glaser C et al. Human rabies includes early generalized vasospasm of cranial arteries that responds to tetrahydrobiopterin, L-arginine or nitroprusside. Towards the elimination of rabies in Eurasia (Joint OIE/WHO/EU International Conference) Paris, 27-30 May 2007 .
17. WILLOUGHBY R.E., Rupprecht CE. Milwaukee protocol for treatment of rabies -- first 10 cases. XVIII International Conference on Rabies in the Americas, Guanajuato, Mexico, September 29-October 5, 2007
18. Opladen T, Schmiedel S, WILLOUGHBY RE, JR., Hoyer J, Hoffmann GF. Tetrahydrobiopterin and neurotransmitter deficiency in human patients with rabies. International conference on tetrahydrobiopterin, PKU and NOS.St.Moritz - Champfér, Switzerland.March 23-28, 2008
19. WILLOUGHBY R.E., Saxinger L, Rubin J, Yee AH, Hyland K, Marrie TJ et al. Metabolomics of human rabies. XIX International Conference on Rabies in the Americas, Atlanta, Georgia, September 28-October 3, 2008
20. David D, WILLOUGHBY RE, JR., Rupprecht CE, Yakobson B, Rubin J. First case of mortality from rabies in the Republic of Equatorial Guinea. XIX International Conference on Rabies in the Americas, Atlanta, Georgia, September 28 - Cctober 3, 2008 , 65.
21. Ribeiro P, das Dores Rodrigues M, do Socorro Rego M, Kotait I, WILLOUGHBY RE, JR., Wada M et al. First rabies patient treated with the Brazilian rabies treatment protocol (Recife Protocol). XX International Conference on Rabies in the Americas, Quebec City, October 19-23, 2009 , 14. 2009.
22. WILLOUGHBY RE, JR. Update on the Milwaukee Protocol-2009. XX International Conference on Rabies in the Americas, Quebec City, October 19-23, 2009 , 14. 2009.
23. WILLOUGHBY RE, JR., Kotait I, David D, Drosten C, Nadin-Davis S, Fooks AR et al. Human antibody responses to dog and bat rabies with the Milwaukee Protocol. XX International Conference on Rabies in the Americas, Quebec City, October 19-23, 2009 , 14. 2009
24. WILLOUGHBY RE, JR. Cytokine response in human rabies. XXI International Conference on Rabies in the Americas, Guadalajara, October 17-22, 2010.
25. WILLOUGHBY RE, JR., CM Slupsky. Metabolomics of human rabies - 2010. XXI International Conference on Rabies in the Americas, Guadalajara, October 17-22, 2010.
26. Dimmock D, WILLOUGHBY, JR R, Leuthner S, Veith R, Gutzeit M, May T, Hambuch T, Worthey E, Jacob H, Tschannen M, North P, Bick D. Clinical whole genome sequencing: One center's experience. 2011 American College of Medical Genetics Annual Clinical Genetics Meeting
27. David D, WILLOUGHBY RE, JR., Niezgoda M, Rupprecht CE, Rubin Y. Human rabies in Equatorial Guinea: Emergence of a new canine rabies virus clade in Africa. XXII International Conference on Rabies in the Americas, San Juan, October 16-21, 2011
28. Wiedeman J, Plant J, Messenger S, Glaser C, Slupsky C, WILLOUGHBY RE, et al. Survival from rabies without neutralizing antibody - California. XXII International Conference on Rabies in the Americas, San Juan, October 16-21, 2011
29. Verma S, Landisch R, Quirk B, Schmainda K, Whelan J and WILLOUGHBY R. Hydrogen sulfide intoxication by invasive S anginosus infection. All-Investigators Gathering, Children's Environmental Health Center Core, Milwaukee, WI, May 3, 2012
30. Jia S, Hessner M, WILLOUGHBY RE. Analysis of RNA expression by blood mononuclear cells stimulated by human rabies CSF. XXIII International Conference on Rabies in the Americas, Sao Paolo, October 14-18, 2012
31. WILLOUGHBY RE, Halligan B, Greene A. Proteomics analysis of human rabies CSF. XXIII International Conference on Rabies in the Americas, Sao Paolo, October 14-18, 2012
32. Galvez S, Baque M, Contreras L, Merino C, Ahumada R, Jamett J, ...[WILLOUGHBY R]..et al. Survivor of rabies encephalitis in Chile. Rabies in the Americas XXIV, Toronto, October 27-31, 2013 . 2013.
33. Zeilonka J, Al-Gisawiy M, Kaul S, Schmainda K, WILLOUGHBY R. Hydrogen sulfide-mediated intoxication by invasive bacteria. First Redox Biology Program Meeting.Cardiovascular Redox Signaling Symposium, Medical College of Wisconsin, Milwaukee, WI, November 14, 2014 .
34. Elsiesy H, Al Sebayel MI, Broering DC, Elgohary AA, Ahmed B, Al Fawaz S, et al. ...[WILLOUGHBY R]..Rabies outbreak involving four transplant recipients in Kuwait and Saudi Arabia. Rabies in the Americas XXVI, Ft.Collins, October 4-8, 2015.
35. French CD, WILLOUGHBY RE, Mwaikambo ED, Granger DL, Foley JF, Wong SJ, et al. Cerebrospinal fluid metabolomics rapidly discriminates rabies from other inflammatory brain diseases. Rabies in the Americas XXVI, Ft.Collins, October 4-8, 2015
36. Hirsch T, Wynia-Smith S, Kristich C, WILLOUGHBY R, Smith B. Inhibiting bacterial H2S production as a potential combination antibiotic therapy [prize winner]. Midwest Enzyme Chemistry Conference, University of Illinois, October 1, 2016
37. WILLOUGHBY, R.E., Kurtz, C., Marquez, M.L., Garigapati, V., Pitruzzello, R., and Neenan, T.X. Synthetic polymers rescure infants from disease in the murine rotavirus model. 35th Annual Meeting of the Infectious Diseases Society of America, September 15, 1997, A721.
38. WILLOUGHBY, R., Watson, D., Welliver, R., Cox, S.R., Wathen, L., Paxton, L., Freimuth, W.,: Phase I evaluation of delavirdine in HIV-1 infected pediatric patients. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, September 27, 1999.
39. WILLOUGHBY, R.E., Rojasthenien, N., and Lietman, P.,: HIVNET 022: A Phase I study to define the pharmacokinetics and safety of 9-[R-2(phosphonomethoxy)propyl]adenine (PMPA) in HIV-1 exposed newborns.
40. Rabies websites with patient registry and protocol (living document): www.mcw.edu/rabiesVersions 1.2; 2.1; 3.1; 4.1; 5.1