CURRICULUM VITAE
Adrian Miranda MD
Adrian Miranda MD
Adjunct Professor
Department of Pediatrics
Division of Gastroenterology
Department of Pediatrics
Division of Gastroenterology
OFFICE ADDRESS: |
Children’s Wisconsin - Specialty Clinics Building |
8915 W Connell Court |
Milwaukee, WI 53226 |
EDUCATION: |
Medical School 1994-1998 M.D. Medical College of Wisconsin, Milwaukee |
- 1990 Undergraduate 1990-1994 B.S. Biology, San Diego State University. San Diego, CA |
WI |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
Milwaukee, WI |
Internship and Residency 1998-2001 Pediatrics |
Children's Hospital of Wisconsin |
Milwaukee, WI |
- 2001 Fellowship 2001-2004 Pediatric Gastroenterology |
Children's Hospital of Wisconsin |
Medical College of Wisconsin |
Medical College of Wisconsin |
FACULTY APPOINTMENTS: |
2004 - 2009 Assistant Professor of Pediatrics |
2009 - 2016 Associate Professor of Pediatrics-Gastroenterology |
2014 - 2018 CHW Section Chief, Children's Hospital of Wisconsin |
2016 - 2018 Medical Director, Infusion Center. Children's Hospital of Wisconsin. |
2016 - Present Professor of Pediatrics-Gastroenterology |
Medical College of Wisconsin |
Milwaukee, WI |
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition |
Milwaukee, WI |
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition |
Medical College of Wisconsin |
Milwaukee, WI |
Division of Pediatric Gastroenterology |
Milwaukee, WI |
Medical College of Wisconsin |
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition |
Milwaukee, WI |
Children's Hospital of Wisconsin |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
Pediatrics | 01/2003 | 01/2010 |
Pediatric Gastroenterology | 10/2005 | 10/2025 |
Licensure | Number | Issue Date | Expiration |
Wisconsin | 41385-020 | 10/99 | 10/31/2024 |
AWARDS AND HONORS: |
2003 - Present Fellows Basic Research Award, Children's Hospital of Wisconsin, Milwaukee, WI. |
2004 - Present Young Investigator Award, Greater Chicago Gut Club, Chicago, IL. |
2004 - Present Young Investigator Award, World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, Paris, France. |
2005 - Present REGAL Award for outstanding research in the field of Gastroenterology. San Francisco, CA. |
2007 - Present "Outstanding Teacher of the Full-Time Pediatric Faculty" Award. |
2008 - Present Young Investigator Award (Basic Science), American Gastroenterologic Association's Functional Brain Gut, San Diego, CA. |
2009 - 2021 "Best Doctors in America" list. |
2011 - Present NASPGHAN, Neurogastroenterology and Motility Basic Science Award, Orlando, Florida. |
2011 - Present Basic Science Award, International Foundation for Functional Gastrointestinal Disorders. Milwaukee, WI. |
2012 - Present NASPGHAN, Neurogastroenterology and Motility Clinical Science Award, Salt Lake City, Utah. |
2016 - Present World Congress of Pediatric Gastroenterology, Basic Science Award, Montreal, Canada. |
Children's Hospital of Wisconsin. |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1998 - Present American Academy of Pediatrics |
2001 - Present American Gastroenterological Association (AGA) |
2001 - Present North American Society for Pediatric Gastroenterology, Hepatology (and Nutrition (NASPGHAN)) |
2006 - Present Functional Brain Gut Research Group |
2014 - Present American Neurogastroenterology and Motility Society (ANMS) |
2017 - Present Expert Provider/Member Grand Rounds Consultation |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2008 - Present NIH NINDS Intramural Grant Reviewer "Brain-Gut interactions in overweight and normal weight women with chronic recurrent abdominal pain". |
2008 - Present NIH NIDDK Study Section Reviewer, Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network |
2008 - Present Scientific Abstract Reviewer for Joint International Neurogastroenterology and Nutrition Meeting, Lucerne, Switzerland |
2009 - 2012 Neurogastroenterology and Motility Committee Member, North American Society for Pediatric Gastroenerology and Nutrition (NASPGHAN) |
2011 - 16 Scientific Abstract Reviewer, American Gastroenterological Association (AGA) |
2011 - Present Guest Editor: Functional Gastrointestinal Disorders and Associated Conditions, Special Edition, Gastroenterology Research and Practice. |
2011 - Present NIH NIDDK Study Section Reviewer: (NIH RFA-DK-10-016), "Fostering the Development of Interdisciplinary Team Science for the Study of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)". |
2015 - Present NIH Study Section Reviewer: Small Business Special |
2016 - Present Member of the American Neurogastroenterology and Motility Society (ANMS) Pediatric Committee |
2018 - Present NIH study section reviewer: ZRG1 DKUS-N (10) Small Business Special Emphasis Panel: Digestive Sciences |
Digestive Disease Week. Washington, D.C. |
Emphasis Panel: (ZRG1 DKUS-N 10) Digestive Sciences. |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2015 - Present Appointed Member: Rome - EMA (European Medicines Agency) Pediatric |
International Committee. The committee is in charge of developing recommendations for endpoints and outcomes of clinical trials in children with functional gastrointestinal disorders. |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
-The International Journal of Neuroscience |
2014 CHW Resident Noon Conference "Abdominal Pain and Abdominal Masses": Children's Hospital of Wisconsin. Milwaukee, WI. |
2013 Emergency Medicine Grand Rounds: "Constipation in Children" Children's Hospital of Wisconsin. Milwaukee, WI. |
2011 CHW Grand Rounds: "Abdominal Pain in Children" Children's Hospital of Wisconsin. Milwaukee, WI. |
2008 Invited Speaker "Vagal Afferent Plasticity Following Gastric Surgery in Rat" The Fourteenth Annual Wylie . Dodds Research Lecture, Milwaukee, WI. |
2008 Invited Speaker "Visceral Hyperalgesia-Are we to blame?" Dysphagia Seminar, Froedtert Hospital, Milwaukee, WI. |
2008 Invited Speaker, "Do Adverse Early Life Events Predispose Children to Develop Chronic Functional Abdominal Pain?" Pediatric Surgical Meeting. Children's Hospital of Wisconsin, Milwaukee, WI. |
2003 Invited Speaker, "What a Pain: Office Approach to Pediatric Abdominal Pain". The Starkey Davis Conference. Children's Hospital of Wisconsin, Milwaukee, WI. |
Invited Manuscript Reviewer |
-Nature Review |
-Gastroenterology |
-Journal of Pediatric Gastroenterology and Nutrition |
-Neurogastroenterology and Motility |
-Neuroscience |
-Autonomic Neuroscience: Basic and Clinical |
-Behavioral and Brain Functions |
-The Journal of Pain |
-Journal of Pediatrics |
-Pain |
Regional |
2012 Invited speaker, Chronic Childhood Bellyaches: Understanding the Disorder and Treatment. Best Practices in Pediatrics Winter Conference, Wisconsin Dells, WI. |
2008 Invited speaker, "Dietary management of Functional Abdominal Pain in Children", ASPEN Conference, Chicago, IL. |
2007 Invited Speaker "Celiac Disease", Grand Rounds, Nena, WI. |
2007 Invited Speaker "Non-surgical Abdominal Pain-office and emergency room work-up", Grays Lake, IL. |
2006 Invited Speaker "Visceral Pain; From Bench to Bedside". Greater Chicago Gut Club. Chicago, IL. |
2005 Invited Speaker "Abdominal Pain in Children". Grand Rounds. Fox Valley, WI. |
2004 Invited Speaker "Management of abdominal pain in children". Best Practices in Pediatrics Winter Conference, Wisconsin Dells, WI. |
2003 Invited Speaker "The Long-Term Management of Inflammatory Bowel Disease in Children". Edgewood College, Madison, WI. |
National |
2018 Invited Speaker: "Updates on functional dyspepsia" North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Hollywood, Florida. |
2017 Invited Speaker: "Treatment of Children with Functional Pain Disorders With and Without Drugs: Where is the evidence?" North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Las Vegas, NV. |
2016 Invited Speaker: "Early Life Stress and Transgenerational Mechanisms in FBD", National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Functional Bowel Disorders (FBD) Workshop: Future Research Directions in Pathophysiology, Diagnosis, and Treatment", NIH Campus, Washington, D.C. |
2015 Invited Speaker: "Medical Management of Refractory Abdominal Pain" NASPGHAN Post-Graduate Course. Washington, D.C. |
2015 Invited Speaker, "The intestine Under Stress, Neuromotor Causes of IBS", American Gastroenterological Association. Washington, D.C. |
2014 Invited speaker, "Pharmacological Treatments for Chronic Abdominal Pain-what you see is not what you get", North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Atlanta, GA. |
2012 Invited speaker, Digestive Disease Week, "Translational Investigation of Visceral Hyperalgesia" AGA, Orlando, FL. |
2012 Invited speaker, State of the Art lecture: "Uncovering Visceral Hyperalgesia" North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Salt Lake City, Utah. |
2011 Presentation of Award-winning abstract "Sleep Interruption Activates the Periaqueductal Grey Region and Results in Visceral and Somatic Hypersensitivity in Rats", North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Orlando |
Florida. |
2011 Invited speaker, "Research Funding: Present and Future". NASPGHAN Second year Pediatric Gastroenterology Fellows Conference, Phoenix, Arizona. |
2011 Invited speaker, "Manuscript Preparation and Submission". NASPGHAN Second year Pediatric Gastroenterology Fellows Conference, Phoenix, Arizona. |
2008 Invited workshop leader, "Pediatric IBS Treatments", NASPGHAN - CDHNF Clinical and Scientific Conference, San Diego, CA. |
2007 Invited speaker "Early Life Events and Functional Abdominal Pain". New insights into childhood functional abdominal pain and IBS: A multidisciplinary approach National Symposium, Salt Lake City, Utah. |
2007 Abstract presentation "The Role of NMDA Receptors in Chronic Visceral Hyperalgesia Following a Neonatal Somatic Stimulus". Digestive Disease Week. Washington, D.C. |
2005 Abstract presentation, "A New Model of Visceral Hyperalgesia in Neonatal Rats". North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. |
International |
2016 Presentation, "Neurostimulation with IBS-Stim Attenuates Amygdala Neurons |
Montreal, Canada |
2010 Invited speaker, "Visceral Pain: From Basics to Bedside" |
First Course of Pediatric Gastroenterology, Mexico D.F., Mexico. |
2010 Invited speaker, "The Child with Abdominal Pain" |
First Course of Pediatric Gastroenterology, Mexico D.F., Mexico. |
2008 Invited speaker, "Early Life Events: What happens to children with functional bowel disorders?" International Meeting of Neurogastroenterology and Motility, Lucerne, Switzerland. |
2004 Presentation "Effects of the 5HT3 Receptor Antagonist, Alosetron, in a Rat Model of Somatic and Visceral Hyperalgesia", 2nd World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. Paris, France. |
and Prevents Post-Inflammatory Visceral and Somatic Hyperalgesia in Rats |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
2002 Noon conference, "IBS in children" |
National |
2015 Lunch and Learn Session Moderator, NASPGHAN post-graduate course: "Practical Approach to Treating the Patient with Persistent Pain and Nausea", Washington, D.C. |
2014 Meet the Professor, Invited Moderator, Vomiting and Reflux in Children, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) national conference. Atlanta, GA. |
2006 NASPGHN Academic Skills Workshop: New Orleans, LA. |
2004 "Acute Nociceptive Somatic Stimulus Sensitizes Neurons in the Spinal Cord to Colonic Distension in the Rat". Digestive Disease Week. New Orleans, LA. |
2014 Webinar Invited Speaker: Fructose Malabsorption, Are You Effectively Managing Carbohydrate Induced Diarrhea in Your Pediatric Patients? NASPGHAN and NASPGHAN Foundation for Children's Digestive Health and Nutrition |
COMMITTEE SERVICE: |
Hospital |
2007 - 2010 Academic Standing Committee Member |
2008 - 2012 Intern Selection Committee Member |
2011 - Present Digestive Disease Center Research Committee, Co-Chair |
2014 - Present Children's Hospital of Wisconsin, Operating Room Committee Member |
2014 - 2018 Children's Hospital of Wisconsin, Joint Patient Care Committee Member |
2014 - Present Digestive Disease Center Research Committee, Chair |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
2011-2012 Thesis Advisor for Khalil El-Chammas, M.D., MS. Medical College of Wisconsin |
2009-2010 Thesis Advisor for Angela Majeskie, MS. Medical College of Wisconsin |
Residents |
2010-2012 Advisor Brittany Goldberg (PL2), Pediatric Resident |
2008-Present Advisor, LaRAMA Medical Society, Medical College of Wisconsin |
2010-2014 Advisor, Apprenticeship in Medicine (AIM) program' Medical College of Wisconsin |
2005-2007 Laboratory Research Mentor for Cass Smith, M.D. Pediatric Gastroenterology Fellow |
(Pediatric Gastroenterology Faculty, Salt Lake City, Utah) |
Undergraduate Laboratory Student Advisor for |
2004-2017 Shachar Peles, M.D. -Internal Medicine faculty, University of Wisconsin, Madison. |
Enisa Hodzic, M.D. - General Pediatrician in Aurora Medical Group, Hartford, WI. |
Eric Nordstrom, M.D. - Gastroenterology faculty, Aurora, Colorado. |
Aaron Mickle PhD, Neuroscience PhD (University of Iowa). Currently Postdoctoral Research Associate, Washington University School of Medicine. |
Mitchel Bruckert-Veterinarian, Milwaukee, WI |
Reji Babygirija, PhD Candidate. UW Madison |
Faculty |
2013 - 2014 MCW Diversity Summer Enrichment Program Mentor |
2017-present Mentor, Katja Kovacic, M.D, NIH Loan Repayment Program |
2015-2017 Advisor and Mentor, Katja Kovacic, M.D, CTSI Clinical Scholars Program |
2013 Advisor for Sara Williams, CTSI Clinical Scholars Program |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. 1 Dharmaraj R, Dunn R, Fritz J, Dasgupta M, Simpson P, Cabrera J, Miranda A, Lerner DG. Efficacy and Safety of Carbon Dioxide Versus Air Insufflation for Colonoscopy in Deeply Sedated Pediatric Patients. J Pediatr Gastroenterol Nutr. 2020;71:34-39. |
2. 2 Chumpitazi, B. P., Lewis, J., Cooper, D., D'Amato, M., Lim, J., Gupta, S., Miranda, A, Terry, N., Mehta, D., Scheimann, A., O'Gorman, M., Tipnis, N., Davies, Y., Friedlander, J., Smith, H., Punati, J., Khlevner, J., Setty, M., & Di Lorenzo, C. (2020). Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PloS one, 15(5), e0231891. |
3. 3 Kovacic K, Kapavarapu PK, Sood MR, Li BUK, Nugent M, Simpson P, Miranda A. Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders. Neurogastroenterol Motil. 2019;31:7. |
4. 4 Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, DiLorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018;30:76. |
5. 5 Kovacic K, Hainsworth K, Sood M, Chelimsky G, Unteutsch R, Nugent M, Simpson P, Miranda A. Neurostimulation for abdominal pain-related functional gastrointestinal disorders in adolescents: a randomized, double-blind, sham-controlled trial. Lancet Gastroenterol Hepatol. 2017;2:727-737. |
6. 6 Babygirija R, Sood M, Kannampalli P, Sengupta JN, Miranda A. Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. Neuroscience. 2017 25;356:11-21. |
7. 7 Miranda A and Taca A. Neuromodulation with Percutaneous Electrical Nerve Field Stimulation is Associated with Reduction in Signs and Symptoms of Opioid Withdrawal: A Multisite, Retrospective Assessment. Am J Drug Alcohol Abuse. 2017;16:1-8. |
8. 8 Saps M, Miranda A. Gastrointestinal Pharmacology. Handb Exp Pharmacol. 2017;239:147-176. |
9. 9 Saps M, Miranda A.L. van Tilburg, Lavigne J, Miranda A, Benninga M, Taminiau J, Di Lorenzo, C. Recommendations for Pharmacological Clinical Trials in Children with Irritable Bowel Syndrome. The Rome Foundation Pediatric Subcommittee on Clinical Trials and The European Medicines Agency. Neurogastroenterol Motil. 2016;28:1619-1631. Review. |
10. 10 Greenley RN, Gumidyala AP, Nguyen E, Plevinsky JM, Poulopoulos N, Thomason MM, Walter JG, Wojtowicz AA, Blank E, Gokhale R, Kirschner BS, Miranda A, Noe JD, Stephens MC, Werlin S, Kahn SA. Can You Teach a Teen New Trick? Problem Solving Skills Training Improves Oral Medication Adherence in Pediatric Patients with Inflammatory Bowel Disease Participating in a Randomized Trial. Inflammatory Bowel Diseases, 2015;21(11):2649-57. |
11. 11 El-Chammas K, Williams SE, Miranda A. Disaccharidase Deficiencies in Children with Chronic Abdominal Pain. Journal of Parenteral and Enteral Nutrition, 2015;41:463-469. |
12. 12 Miranda A, Mickle A, Bruckert M, Kannampalli P, Banerjee B, Sengupta JN. NMDA Receptor Mediates Chronic Visceral Pain Induced by Neonatal Noxious Somatic Stimulation. European Journal of Pharmacology, 2014;744:28-35. |
13. 13 Kannampalli P, Pochiraju S, Chichlowski M, Berg B, Rudolph C, Bruckert B, Miranda A and Sengupta JN. Probiotic Lactobacillus rhamnosus GG (LGG) and Prebiotic Prevent Neonatal Inflammation-induced Visceral Hypersensitivity in Adult Rats. Neurogastroenterology & Motility, 2014;26:1694-704. |
14. 14 Miranda, A. and Saps, M. The Use of Non-Narcotic Pain Medication in Pediatric Gastroenterology. Pediatric Drugs, 2014;16:293-307. |
15. 15 Altaf MA, Ciecierega T, Szabo S, Miranda A, Gorges C, Simpson P, Sood MR. Comparison of Light and Electron Microscopy in Measurement of Esophageal Intercellular Space in Children. J Pediatr Gastroenterol Nutr. 2014;59:232-6. |
16. 16 Mohammad S, Di Lorenzo C, Youssef NN, Miranda A, Nurko S, Hyman P, Saps M. Assessment of Abdominal Pain Through Global Outcomes and Recent FDA Recommendations in Children. Are We Ready for Change? J Pediatr Gastroenterol Nutr. 2014;58:46-50. |
17. 17 Kovacic K, Miranda A, Chelimsky G, Williams S, Simpson P, Li BU. Chronic Idiopathic Nausea of Childhood. J Pediatr. 2014;164:1104-9. |
18. 18 Sengupta JN, Mickle A, Kannampalli P, Spruell R, McRorie J, Shaker R, Miranda A. Visceral analgesic effect of 5-HT4 receptor agonist in rats involves the rostroventral medulla (RVM). Neuropharmacology. 2013;79C:345-358. |
19. 19 Kovacic K, Williams S, Li BK, Chelimsky G, Miranda A. High Prevalence of Nausea in Children with Pain-Associated Functional Gastrointestinal Disorders: Are Rome Criteria Applicable? J Pediatr Gastroenterol Nutr. 2013;57:311- 315. |
20. 20 El-Chammas K, Majeskie A, MS1, Simpson P, Sood M, Miranda A. Red Flags in Children with Chronic Abdominal Pain and Crohn's Disease- a Single Center Experience. J.Ped. 2013;162:783-7. |
21. 21 Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B. MicroRNA-mediated GABAA<alpha>-1 receptor subunit downregulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats. Pain. 2013;154:59-70. |
22. 22 Mickle A, Miranda A, Banerjee B, Sengupta JN. Pronociceptive effect of serotonin 5-HT1A receptor agonist in visceral pain involves spinal NMDA receptor. Neuroscience. 2012;219:243-54. |
23. 23 Chogle A, Sztainberg M, Youssef NN, Miranda A, Nurko S, Hyman P,Cocjin J, Di Lorenzo C, Saps M. Accuracy of pain recall in children. J Pediatr Gastroenterol Nutr. 2012;55:288-291. |
24. 24 Greenley RN, Kunz JH, Biank V, Martinez A, Miranda A, Noe J, Telega G, Tipnis NA, Werlin S, Stephens MC. Identifying youth nonadherence in clinical settings: Data-based recommendations for children and adolescents with inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:1254-9. |
25. 25 Miranda A, Mickle A, Schmidt J, Zhang Z, Shaker R, Banerjee B, Sengupta JN. Neonatal cystitis-induced colonic hypersensitivity in adult rats: A model of viscero-visceral convergence. Neurogastroenterol Motil. 2011;23:683. |
26. 26 Sood M, Di Lorenzo C, Hyams J , Simpson P, Mousa H, Miranda A, Sandla K, Nurko S. Beliefs and attitudes of general pediatricians and pediatric gastroenterologists regarding functional gastrointestinal disorders - A survey study. World Gastroenterolgy. Clin Pediatr (Phila). 2011;50:891-6. |
27. 27 Mickle A, Sood M, Zhang Z, Shahmohammadi G, Sengupta JN, Miranda A. Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: A centrally mediated process. Pain. 2010;149:555-64. |
28. 28 Adamiak T, Altaf, M, Jensen MK, Sultan M, Ramprasad R, Ciecierega T, Sherry K, Miranda A. One day preparation with polyethylene glycol (PEG) 3350: an effective regimen for colonoscopy in children. Gastrointest Endosc. 2010;71:573-7. |
29. 29 Saps M, Youssef N, Miranda A, Nurko S, Kagalwalla A, Di Lorenzo C. A randomized, double blind, placebo controlled, multi-center trial of amitriptyline in children with functional abdominal pain. Gastroenterology. 2009;137:1261-9. |
30. 30 Miranda A, Mickle A, Medda BK, Phillips RJ, Tipnis N, Reza Shaker, Powley TL, Sengupta J N. Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats. Neuroscience, 2009;162:1299-306. |
31. 31 Banani B, Medda BK, Zheng Y, Miller H, Miranda A, Sengupta JN, Shaker R. Alterations in N-methyl-D-aspartate receptor subunits in primary sensory neurons following acid-induced esophagitis in cats. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2009;296:G66-77. |
32. 32 Dua, K, Miranda A, Santharam R, Ramanujam S, Werlin S. Endoscopic retrograde cholangio-pancreatography (ERCP) in the evaluation of abdominal pain in children. Gastrointestinal Endoscopy. 2008;68:1081-5. |
33. 33 Miranda A, Nordstrom E, Mannem A, Smith C, Banerjee B, Sengupta JN. The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis. Neuroscience. 2007;148:1021-32. |
34. 34 Smith C, Nordstrom E, Sengupta JN, Miranda A. Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Neurogastroenterol Motil. 2007;19:692-9. |
35. 35 Smith CR, Miranda A, Rudolph CD, Sood MR. Removal of impacted food in children with eosinophilic esophagitis using saeed banding device. J Pediatr Gastroenterol Nutr. 2007;44:521-523. |
36. 36 Miranda A, Peles S, McLean PG, Sengupta JN.Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Pain. 2006;126:54-63. |
37. 37 Miranda A, Peles S, Shaker R, Rudolph C, Sengupta JN. Neonatal nociceptive somatic stimulation differentially modifies the activity of spinal neurons in rats and results in altered somatic and visceral sensation. J Physiol. 2006;572:775-87. |
38. 38 Peles S, Miranda A, Shaker R, Sengupta JN. Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat. J Physiol. 2004;560:291-302. |
39. 39 Miranda A, Peles S, Rudolph C, Shaker R, Sengupta JN. Altered visceral sensation in response to somatic pain in the rat. Gastroenterology. 2004;126:1082-9. |
40. 40 Kugathasan S, Miranda A, Nocton J, Drolet BA, Raasch C, Binion DG. Dermatologic manifestations of Crohn disease in children: response to infliximab. J Pediatr Gastroenterol Nutr. 2003;37:150-4. |
Books, Chapters, and Reviews |
1. Miranda, A. Visceral Sensitivity. In Pediatric Neurogastroenterology. Springer Nature Switzerland AG, 2023. |
2. Miranda, A. Abdominal Pain. in Nelson Pediatric Symptom Based Diagnosis. 2nd edition. Elsevier Health Sciences. 2022. |
3. Kovacic, K. and Miranda A. Approach to the Child with Chronic Abdominal Pain. In Rudolph's Pediatrics 23nd edition, McGraw Hill, New York, 2017 |
4. Miranda, A. Abdominal Pain. Nelson's Symptom-Based Diagnosis. Elsevier, 2016. |
5. Lerner D and Miranda A. Diagnostic and Therapeutic Options in Children with Lower Gastrointestinal Bleeding. In Gastrointestinal Endoscopy in Children. Nova Science Publishers, Inc. Hauppauge, NY. 2014 |
6. Miranda A. Approach to the Child with Chronic Abdominal Pain. In Rudolph's Pediatrics 22nd edition, McGraw Hill, New York, 2010. |
7. Miranda A. Early Life Stress and Pain: An Important Link to Functional Bowel Disorder. Pediatr Ann. 2009;38:279-82. |
8. Miranda, A. Early Life Events and the Development of Visceral Hyperalgesia: Functional abdominal pain: time to get together and move forward. J Pediatr Gastroenterol Nutr. 2008;47:679-80 |
9. Sengupta JN, Shaker R, Miranda A. Visceral Pain Model, Esophageal Pain. In Encyclopedic Reference of Pain, ed Schmidt, R.F. Willis, W.D. Springer-Verlag, New York. 2006. |
10. Miranda A, Sood M. Treatment options for chronic abdominal pain in children and adolescents. Curr Treat Options Gastroenterol. 2006;9:409-15 |
11. Rudolph CD, Miranda A. Treatment options for functional abdominal pain. Pediatr Ann. 2004;33:105-12 |
Editorials, Letters to Editor, Other |
1. 2017 Miranda A, Auricular Stimulation for Chronic Abdominal Pain. Lancet Podcast. |
2. 2014 Miranda A. Data on Diet and IBS, editorial to FODMAPS for IBS, Who Will Benefit. Gastrointestinal & Endoscopy News, 2014;64:20-21. |
3. 2012 Channel 4 (TMJ4) interview, special report "Children with belly pain". |
4. 2004 Telephone Interview: Parents Magazine. "Chronic Abdominal Pain in Children and Association with Anxiety Disorders" |
Abstracts |
1. Williams S and Miranda A. Mood, Sleep and HPA reactivity in Children with Abdominal Pain: A comparison between objective and subjective reports. JPGN Volume 55, Suppl 1, October 2012 |
2. Miranda A, Raff H, Williams S. Salivary Amylase as a Biomarker for Functional Abdominal Pain in Children: Role of Sleep and Melatonin. JPGN Volume 55, Suppl 1, October 2012. |
3. Kovacic K, Li BUK, Williams S, Sood M and Miranda A. Nausea in Children with Pain-Associated Functional Bowel Disorders: Usefulness of Rome Criteria. NASPGHAN meeting. October 2012. |
4. Bruckert M., Kannampalli P., Pochiraju S., Banerjee B., Sengupta J.N., and Miranda A. Role of Periaqueductal Gray NMDA and µ-Opioid Receptors in Sleep Interruption Induced Visceral Hyperalgesia. NASPGHAN meeting. October 2012. |
5. Mickle A, Sood M, Miranda A. Comparison of Red Flags and Family History in Pediatric Functional Gastrointestinal Disorders and Crohn's Disease. Gastroenterology Supplement, October 2010 |
6. Miranda A, Mickle A, Sengupta J. Neonatal Esophageal Bile Exposure Results in Dilated ICS and Altered Mechanosensitive Properties of Vagal Afferent Fibers. October 2010 |
7. Mohammad S1, Youssef N, Miranda A, Nurko S, Hyman P, Di Lorenzo C, Saps M. Assessment of Abdominal Pain Through Global Outcomes and Recent FDA Recommendations in Children, October, 2010 |
8. Ciecierega T, Altaf M, Miranda A, Tipnis N, Szabo S, Rudolph C, Sood M |
9. Altered Esophageal Epithelial Intercellular Space- A Marker of Esophageal Injury in Children with Reflux Symptoms. October 2010 |
10. Miranda A, Mickle A, Schmidt J, Zhang Z, Sengupta JN. Neonatal Cystitis Induced Colonic Hypersensitivity in Adult Rats: a model of viscero-visceral convergence. Gastroenterology Supplement, October 2010. |
11. Miranda A, Mickle A, Zhang Z, Sengupta JN. Melatonin Attenuation of Post-inflammatory Visceral Hyperalgesia: A Centrally Mediated Process Gastroenterology Supplement, May 2009. |
12. Sengupta JN Mickle A, Zhang Z, Medda BK, Schmidt J, Shaker R, Spruell R, McRorie J, Miranda A. Analgesic effect of tegasered in visceral pain is not peripheral, but via the central the opiodergic system. Gastroenterology Supplement, May 2009. |
13. Saps M, Youssef N, Miranda A, Nurko S, Kagalwalla A, Di Lorenzo C. A Randomized, Double Blind, Placebo Controlled, Multi-Center Trial of Amitriptyline in Children with Functional Abdominal Pain. J.of Ped Gastro & Nutrition, Supplement Nov. 2008. |
14. Saps M, Youssef N, Miranda A, Nurko S, Kagalwalla A, Di Lorenzo C, Seasonal Variation in Response to Treatment in Children with Functional Abdominal Pain. J.of Ped Gastro & Nutrition. Supplement Nov. 2008. |
15. Miranda A, Mickle A, Schmidt J, Banerjee B, Medda B, Shaker R, Sengupta JN. Fundus Ligation in Adolescent Rats Chronically Alters the Responses of Vagal Mechanosensitive Afferents Innervating the Stomach and Results in Expansion of Receptive Field. Gastroenterology Supplement May 2008. |
16. Miranda A, Thibaudeau D, Medda BK, Banerjee B, Sengupta JN The Role of NMDA Receptors in Chronic Visceral Hyperalgesia Following a Neonatal Somatic Stimulus. Gastroenterology Supplement, May 2007. |
17. Smith C, Miranda A, Rudolph C, Sood M. Use of Saeed Banding Device for Removal of Impacted Food In Children with Eosinophilic Esophagitis. J.of Ped Gastro & Nutrition. Supplement Oct 2006. |
18. Miranda A, Nordstrom E, Smith C, Sengupta JN. The TRPV1 Receptor Antagonist JYL- 1421 Prevents Submucosal Colonic Inflammation and Visceral Hyperalgesia in Rats. J. of Ped Gastro & Nutrition. Supplement Oct 2006. |
19. Smith C, Nordtrom E, Sengupta JN, Miranda A. Neonatal Gastric Suctioning Results in Chronic Visceral and Somatic Hyperalgesia in Adult Rats. Gastroenterology, Volume 130, Number 4, Supplement 2:M2250, April 2006. |
20. Hodzic E, Knuff D, Miranda A, Shaker R, Sengupta JN. Differential Effects of Central NMDA Receptor Antagonists in Rat Models of Inflammatory and Non-Inflammatory Visceral Hyperalgesia. Gastroenterology, Volume 128, Number 4, Supplement 2:S402, April 2005. |
21. Miranda A, Peles S, Rudolph C, Sengupta JN. Neonatal Noxious Somatic Stimulation Differentially Modifies the Activity of Two Classes of Dorsal Horn Neurons and Results in Visceral Hyperalgesia in Adult Rats. Gastroenterology, Volume 128, Number 4, Supplement 2:S1476, April 2005. |
