Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

CURRICULUM VITAE

Allison S. Remiker MD
Assistant Professor
Department of Pediatrics
Division of Hematology and Oncology - Pediatrics

OFFICE ADDRESS:
Children’s Wisconsin - Milwaukee Hospital
8915 W Connell Court
Milwaukee, WI 53226

EDUCATION:
09/2002 - 05/2007 BA, University of Wisconsin, Madison, WI
08/2008 - 05/2012 MD, University of Wisconsin School of Medicine and Public Health, Madison, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
06/2012 - 06/2015 Resident, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN
07/2015 - 07/2018 Fellow, Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH
01/2022 - 01/2025 Sickle Cell Quality Improvement Academy (SQUAD), Quality Improvement Training, Armstrong Institute for Patient Safety and Quality at Johns Hopkins University School of Medicine

FACULTY APPOINTMENTS:
08/2018 - 08/2019 Instructor of Pediatrics, Department of Pediatrics, Division of Pediatric Hematology/Oncology/Neuro-oncology/Stem Cell Transplant, Northwestern University Feinberg School of Medicine
09/2019 - 08/2021 Assistant Professor of Pediatrics, Department of Pediatrics, Division of Pediatric Hematology/Oncology/Neuro-oncology/Stem Cell Transplant, Northwestern University Feinberg School of Medicine
08/2021 - Present Assistant Professor of Pediatrics, Department of Pediatrics, Division of Pediatric Hematology and Oncology, Medical College of Wisconsin

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
05/2019 - 08/2021 Program Director, Co-clinic Director, Immune Hematology Program, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
01/2022 - Present Program Director, Comprehensive Thalassemia Program, Pediatrics, Hematology/Oncology/BMT, Children's Wisconsin, Milwaukee, WI
06/2022 - Present Program Director, Immunohematology Program, Pediatrics, Hematology/Oncology/BMT, Children's Wisconsin, Milwaukee, WI
10/2022 - Present Interim Assistant Hematology Program Director, Pediatrics, Hematology/Oncology/BMT, Children's Wisconsin, Milwaukee, WI 53226

HOSPITAL STAFF PRIVILEGES:
08/2018 - 08/2021 Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
08/2018 - 08/2021 Northwest Community Hospital, Arlington Heights, IL
01/2019 - 02/2021 MercyHealth Javon Bea Hospital, Rockford, IL
08/2021 - Present Children's Hospital of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
General Pediatrics
10/2015
2025
Pediatric Hematology/Oncology
04/2021
2031
   
Licensure
Number Issue DateExpiration
Ohio State License
35.126791
06/25/2015
07/01/2021
Illinois State License
IL-036.146523
06/21/2018
07/31/2023
Wisconsin License
75702-20
07/20/2021
10/31/2023
    

AWARDS AND HONORS:
2002 - 2006 Gregg Menn Memorial Scholarship
2002 Madeleine Laux Scholarship
2003 - 2007 Charles Boydd Scholarship
2003 - 2007 National Collegiate Honors Society
2009 Shapiro Research Scholar
2010 Alice and Philip Farrell Scholarship for Student Leaders
2010 Wisconsin Medical Alumni Association Student Scholarship
2010 - 2012 Research Honors Program Graduate Certificate
2012 - 2015 Morris Green Research Scholars Program
2013 Abby Brinkman Intern Teacher of the Year Award
2013 Resident of the Month
2014 Gold Humanism Honor Society Inductee
2014 Platform Presentation at the 11th Annual Indiana University Pediatric Scholars Day
2017 - 2018 Chief Fellow, Cincinnati Children's Hospital Medical Center
2017 American Society of Hematology (ASH) Research Training Award for Fellows
2017 American Society of Hematology (ASH) Abstract Achievement Award
2018 American Society of Pediatric Hematology/Oncology (ASPHO) Early Career Travel Stipend Award
2020 Northwestern University Feinberg School of Medicine Teaching Pin
ThedaCare Medical Staff Scholarship. 2006, 2009, 2010

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2011 - Present American Academy of Pediatrics (AAP)
2014 - Present Gold Humanism Honor Society
2016 - Present American Society of Pediatric Hematology and Oncology (ASPHO)
2017 - Present American Society of Hematology (ASH)
2019 - Present North American Immuno-Hematology Clinical Education & Research Consortium (NICER)
2019 - Present Pediatric ITP Consortium of America (ICON)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
08/2021 - Present Annals of Medicine
Ad-Hoc Reviewer
08/2021 - Present Invited abstract reviewer, North American Immuno-Hematology Clinical Education & Research Consortium (NICER) Annual Meeting
02/2022 Journal review, Pediatrics in Review
05/2022 Journal review, Journal of Pediatric Hematology/Oncology
06/2022 Journal review, Journal of Pediatric Hematology/Oncology
07/2022 Journal review, Journal of Pediatric Hematology/Oncology
08/2022 Invited abstract reviewer, North American Immuno-Hematology Clinical Education & Research Consortium (NICER) Annual Meeting
12/2022 Journal review, Journal of Pediatric Hematology/Oncology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
06/2022 - Present Member, Steering Committee, North American Immuno-Hematology Clinical Education & Research Consortium (NICER)
09/2022 - Present Committee Co-chair, Pediatric ITP Consortium of America (ICON)
09/2022 - Present Member, Operations Committee, Patient Centered Outcomes (PCO)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Hydroxyurea Optimization through Precision Study (HOPS): A prospective, multi-center, randomized trial of personalized, pharmacokinetics-guided dosing of hydroxyurea versus standard weight-based dosing for children with sickle cell anemia
Source:
Doris Duke Charitable Foundation
Role:
Site primary investigator
PI:
Patrick McGann, MD
Dates:
01/17/2019 - 12/31/2023
  
Title:
Sickle Cell Disease Treatment with Arginine Therapy (STArT Trial)
Source:
NIH Heart Lung and Blood Institute
Role:
Co-investigator
PI:
David Brousseau, MD
Dates:
10/01/2020 - 08/31/2026
Direct Funds:
$98,452
  
Title:
Contract: Sickle Cell Treatment Demonstration Project- STORM
Source:
Cincinnati Children’s Hospital Medical Center
Role:
Principal investigator
Dates:
09/01/2021 - 08/31/2026
  
Title:
Contract: Wisconsin Congenital Disorder/Newborn Screening Program
Source:
State of Wisconsin
Role:
Principal investigator
Dates:
07/01/2022 - 06/30/2023
  
Title:
Retrospective Cohort Study of Pediatric AIHA at ICON Centers
Source:
N/A
Role:
Site primary investigator
PI:
Rachael Grace, MD
Dates:
10/05/2022 - Present
  
Prior
Peer Review
Title:
Research Training Award for Fellows (RTAF)
Source:
American Society of Hematology (ASH)
Role:
Principal Investigator
Dates:
07/2017 - 06/2018
Direct Funds:
$70,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Allison Remiker, Lurie Children's Hospital Immune Hematology Program, Department of Pediatrics Grand Rounds, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; April 2020, 04/2020
Allison Remiker, Ace the Boards Pediatric Hematology Session, Children's Wisconsin, Milwaukee, WI, 08/2022
Allison Remiker, Larisa Broglie, Abdul Elkadri, The who, what, why, and how of Immune Dysregulation: How to recognize it and who to call. Department of Pediatrics Grand Rounds, Children’s Wisconsin, Milwaukee, WI, 11/2022
Allison Remiker, Ace the Boards Pediatric Hematology Session, Children's Wisconsin, Milwaukee, WI, 08/2023
 
National
Remiker, A., Chuang, J., Corathers, S., Rutter, M.M., Ho, B., Rutter, M., Myer, C., Gelfand, A., Trout, A., Geller J., Differentiated Thyroid Cancer Outcomes in the Pediatric/Adolescent Population: A Longitudinal Review from a Single Center. Oral communication, American Society of Pediatric Hematology,Thyroid Cancer Special Interest Group, Montreal, Canada, 2017
Allison Remiker, Lisa Forbes Satter and Danielle Arnold., Immune Dysregulation in the Context of Immunotherapy. Panel discussion, North American Immuno-Hematology Education & Research Consortium (NICER) Annual Meeti, 09/2021
Allison Remiker, Sickle Cell and MIS-C. Sickle Cell Treatment Demonstration Project- STORM ECHO Pediatric Case Presentation, 11/2022
Allison Remiker, Managing Iron Overload in Thalassemia. Central Region Thalassemia Collaborative TeleECHO Didactic and Case Presentation, 12/2022
Allison Remiker, Sherif Badawy, Ashish Kumar and Melissa Rose., Immunohematology. Educational Session, American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting, Pittsburgh, PA, 2022
Allison Remiker and Harry Lesmana, Tales from the Case Conference, NICER Symposium, Pittsburgh, PA, 2023
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Pratt, A., Spiegel, C., Delgado, D., Renbarger, J., Skiles, J., Haut, P., Robertson, K., Goebel, W.S. (2014). Long-term Survival Can Be Achieved with Second Stem Cell Transplants in Children with Relapsed Hematologic Malignancies. Oral communication presented at: 11th Annual Indiana University Pe
 
National
Remiker, A., Rosenfeldt, L., Adams, G., Flick, M.J., Frederick, M., Palumbo, J. (2018) Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis. Platform presentation presented at: American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting, Pittsburgh, PA.
 
International
Remiker, A., Rosenfeldt, L., Adams, G., Flick, M.J., Frederick, M., Palumbo, J. (2017) Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis. Oral communication presented at: International Society of Thrombosis and Hemostasis (ISTH) Congress; Berlin, Germany.
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2022 - 2024 Member, Medical College of Wisconsin Admissions Committee, Medical College of Wisconsin
2022 - Present Member, Pediatric Hematology/Oncology Fellowship Program Evaluation Committee, Medical College of Wisconsin
 
Hospital
2008 - 2012 Elected Board Member/Social Committee Chair, Medical Student Association, University of Wisconsin School of Medicine and Public Health
2009 - 2010 Mentor and Coordinator, Alpha Epsilon Delta Pre-med Honor Society/Medical Student Association, University of Wisconsin School of Medicine and Public Health
2009 - 2010 House Leader, Interhouse Council, University of Wisconsin School of Medicine and Public Health
2017 - 2018 Chief Fellow, Cincinnati Children's Hospital Medical Center
2019 - 2021 Resident, Hematology/Oncology Education Liaison, Northwestern University Feinberg School of Medicine/Lurie Children’s
2020 Chair, Hematology Lab Process Committee, Northwestern University Feinberg School of Medicine/Lurie Children’s
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
01/2022 - Present Medical Student Clinic Preceptor
08/2022 Medical Student Foundations of Clinical Medicine: Small Group Facilitator, 1.5 hours,
09/2022 Medical Student Foundations of Clinical Medicine: Small Group Facilitator, 1.5 hours,
11/2022 Medical Student Foundations of Clinical Medicine: Small Group Facilitator, 1.5 hours
09/2023 Medical Student Early Clinical Learning: Exam Skills, 4 hours
 
Resident and Fellow Education
03/2022 Sickle Cell Anemia Noon Lecture
2022 - 2023 Diversity Discussions, 4 sessions per academic year, Academic 2022-23 – current. Example topics: racism and sickle cell disease, visiting a refugee center, Hmong culture and medicine.
03/2023 Hospital Medicine Fellow Thrombocytopenia Lecture
06/2023 SIPPS Standardized Patient Intern Orientation Workshop
09/2023 Hospital Medicine Fellow Bleeding and Clotting Disorder Lecture
12/2023 Immune Thrombocytopenia Lecture
 

EXTRAMURAL TEACHING:
Medical Student Education
08/2018 Northwestern University Feinberg School of Medicine, Neuroscience Module Moderator, Delivery of Optimized Care Sessions 3.5 hours
02/2019 Northwestern University Feinberg School of Medicine, Case Based Learning Moderator, Heme Malignancies 2 hours
2019 - 2020 Northwestern University Feinberg School of Medicine, Medical Decision-Making Small Group Leader M1 students Academic Ten 1-hour sessions
02/2020 Northwestern University Feinberg School of Medicine, Case Based Learning Moderator, Oncology 2 hours
 
Resident and Fellow Education
2019 - 2021 Northwestern University Feinberg School of Medicine, Autoimmune Hemolytic Anemia Lecture, Yearly
2019 - 2021 Northwestern University Feinberg School of Medicine, Immune Thrombocytopenia Lecture, Yearly
2021 Northwestern University Feinberg School of Medicine, Immunodeficiency Lecture
2021 Northwestern University Feinberg School of Medicine, Bone Marrow Failure Lecture
Northwestern University Feinberg School of Medicine, Immune-mediated Cytopenias Lecture, Monthly, On-service residents
 

PROGRAMMATIC DEVELOPMENTS:
 
 
Clinical Programs
08/2022 Comprehensive Thalassemia Program multidisciplinary clinic development
09/2022 Immunohematology Clinic development
10/2022 Sickle cell and pulmonary combination clinic development
 
Community Programs
02/2022 Hematology Vitamin D Guideline
04/2022 Sickle Cell Stroke Pathway
11/2022 Transfusion Dependent Thalassemia and Non-transfusion Dependent Thalassemia Care Guidelines
 

COMMUNITY SERVICE ACTIVITIES:
2008 - 2010 MEDiC, Free health clinic volunteer
2009 - 2010 Mothers and Maternity Support (MoMS) Program, Pregnant mother sponsor
2014 - 2015 Camp Riley, Camp Physician, Indianapolis, IN
2017 Camp Joy, Camp Physician, Cincinnati, OH
2023 - Present Department of Pediatrics Diversity and Inclusions Committee
 

GLOBAL HEALTH ACTIVITIES:
04/2009 - 05/2009 Hillside Clinic, Belize, Family Medicine rotation
06/2009 Kampala, Uganda, Public health educational medical experience
11/2013 Hubei China, Pediatric team for diagnostics and treatment plans for children with developmental needs in an orphanage
 

QUALITY IMPROVEMENT PROJECTS:
01/2022 - 01/2025 Title: Improving MRI/MRA Screening Rates in Children’s with Sickle Cell Disease Source: N/A Role: Co-primary investigator PI: Self and Dr. Ashima Singh Direct Funds: N/A
09/01/2022 - 01/2025 Title: Immune Thrombocytopenia Quality Improvement Pathway Source: N/A Role: Site primary investigator PI: Rachael Grace, MD Direct Funds: N/A


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Durrani, S., Montville, D., Pratt, A., Sahu, S., Devries, M., Rajamanickam, V., Gagnon, R., Gill, M., Gern, J., Lemanske, R., Jackson, D. Innate Immune Responses to Rhinovirus are Reduced by the High-Affinity IgE Receptor in Allergic Asthmatic Children. J Allergy Clin Immunol, 2012.
2. Remiker, A.S. and Palumbo, J.S. Mechanisms Coupling Thrombin to Metastasis and Tumorigenesis. Thrombosis Research, 2018; 164 Suppl 1:S29-S33.
3. Remiker, A.S., Chuang, J., Corathers, S., Rutter, M.M., Rutter, M.J., Myer, C.M., Gelfand, M.J., Trout, A.T., Geller, J.I. Differentiated Thyroid Cancer in the Pediatric/Adolescent Population: Evolution of Treatment. J Pediatr Hematol Oncol, 2019.
4. Remiker A., Haslam D., Kalfa T.A. A painless erythematous swelling of the external ear as a manifestation of Lyme disease: a case report. J Med Case Rep, 2020; Apr 16; 14(1):48.
5. Lust H., Gong S., Remiker A., Rossof J.. Idiopathic multicentric Castleman disease with TAFRO clinical subtype responsive to IL-6/JAK inhibition: A pediatric case series. Pediatr Blood Cancer 2021 Oct;68(10):e29261.
6. Leiding J.W., Vogel T.P., Valentine G.J.,…STAT3 Working Group…et al., Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. JACI 2022 Oct; in press.
7. Escobar Vasco A., Broglie L., Talano J-A., Routes J., Verbsky J., Remiker A. GATA2 deficiency detected by newborn screening for SCID: A case report. Frontiers Pediatr 2023 Jan; 10:1031106.
8. Remiker A. Pancytopenia in a 16-year-old boy. Pediatr Rev 2023. (Accepted)
9. Remiker A. Pancytopenia in a 16-year-old boy. Pediatr Rev 2023. 2023 Oct 01;44(S1):S39-S43
 
Books, Chapters, and Reviews
1. Remiker AS and Brandow AM. Polycythemia. Nelson Textbook of Pediatrics 22nd Edition. 2022
2. Remiker AS and Brandow AM. Non-Clonal Polycythemia. Nelson Textbook of Pediatrics 22nd Edition. 2022
3. Remiker AS and Brandow AM. Anatomy and Function of the Spleen. Nelson Textbook of Pediatrics 22nd Edition. 2022
4. Remiker AS and Brandow AM. Splenomegaly. Nelson Textbook of Pediatrics 22nd Edition. 2022
5. Remiker AS and Brandow AM. Hypersplenism, Splenic Trauma, and Splenectomy. Nelson Textbook of Pediatrics 22nd Edition. 2022
6. Remiker AS and Brandow AM. Hemolytic Anemias Resulting from Extracellular Factors--Immune Hemolytic Anemias. Nelson Textbook of Pediatrics 22nd Edition. 2022
7. Remiker AS and Brandow AM. Hemolytic Anemias Secondary to Other Extracellular Factors. Nelson Textbook of Pediatrics 22nd Edition. 2022
8. Remiker AS and Brandow AM. Pyruvate Kinase Deficiency. Nelson Textbook of Pediatrics 22nd Edition. 2022
9. Remiker AS and Brandow AM. Other Glycolytic Enzyme Deficiencies. Nelson Textbook of Pediatrics 22nd Edition. 2022
10. Remiker AS and Brandow AM. Glucose-6-Phosphate Dehydrogenase Deficiency and Related Deficiencies. Nelson Textbook of Pediatrics 22nd Edition.2022
11. Remiker A, Bolling K, and Verbsky J. Common Variable Immunodeficiency. Medical Clinics of North America. (in production)
12. Remiker A, Bolling K, and Verbsky J. Common Variable Immunodeficiency. Medical Clinics of North America. 2024 Jan; 108(1):107-121.
 
Editorials, Letters to Editor, Other
1. Remiker A., Neunert C. Splenectomy for immune thrombocytopenia: the evolution and preservation of treatment. Haematologica. 2020 11 01; 105(11):2507-2509.
 
Abstracts
1. Bermant, C., Pratt, A., Opsahl, M., Sanchez, H., Bush, R.K. Production of a cDNA library to Harmonia Axyridis Multi-color Lady Beetle. Allergy and Clinical Immunology Vol. 117, No. 2, p.S311, 2006.
2. Knuffman, J.E., Opsahl, M.A., Gern, B.H., Pratt, A.S., Sanchez, H., Bush, R.K. Identification of an Allergen of Harmonia Axyridis (Multicolor Asian Lady Beetle) J. Allergy Clin. Immmunol. Vol. 119, No. 1, p.S106, 2007.
3. Pratt, A., Jackson, D., Lemanske, R.. (2010, January). Plasmacytoid Dendritic Cell Interferon-alpha Responses in Children with Asthma and Allergic Sensitization. Poster presented at: Medical Student Research Forum- UWSMPH; Madison, WI.
4. Montville D., Pratt A., Levinsky N., Tisler C., Rajamanickman V., Gill M., Jackson D.. (2011, March). The Relationships Among Total IgE and Rhinovirus-induced Interferons in Peripheral Blood. Poster presented at: American Academy of Allergy, Asthma, and Immunology Annual Meeting; San Francisco, CA.
5. Hege, K., Groves, C., Britton, R., Skipworth, E., Graves, V., Sexton, S., Huber, V., Harris, H., Schwering, D., Sims, A., Pratt, A., Srivastava, S., Pollok, K., Robertson, K., Goebel, W.S. (2013). Engraftment of Human Peripheral Blood Stem Cells in NOD/SCID/IL- -term Cryopreservation. Poster presented at: American Academy of Blood Banks (AABB) Annual Meeting; Denver, CO.
6. Pratt, A., Spiegel, C., Delgado, D., Renbarger, J., Skiles, J., Haut, P., Robertson, K., Goebel, W.S. (2014). Long-term Survival Can Be Achieved with Second Stem Cell Transplants in Children with Relapsed Hematologic Malignancies. Poster presented at: Pediatric Bone and Marrow Transplant Consortium (PBMTC) in conjunction with American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting; Chicago, IL.
7. Remiker, A., Schwering, D., Sexton, S., Harris, H., Huber, V., Graves, V., Britton, R., Skipworth, E., Goebel, W.S. (2015). Elimination of the Post-Cryopreservation Wash-Step for Umbilical Cord Unit Transplantation. Poster presented at: Pediatric Bone and Marrow Transplant Consortium (PBMTC) in conjunction with American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting; Phoenix, AZ.
8. Remiker, A., Rosenfeldt, L., Adams, G., Flick, M.J., Frederick, M., Palumbo, J. (2017) Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis. Poster presented at: Thomas L. Boat Lecture Series; CCHMC.
9. Remiker, A., Chuang, J., Corathers, S., Rutter, M.M., Ho, B., Rutter, M., Myer, C., Gelfand, A., Trout, A., Geller, J. (2017). Differentiated Thyroid Cancer Outcomes in the Pediatric/Adolescent Population: A Longitudinal Review from a Single Center. Poster presented at: American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting; Montreal, Canada.
10. Remiker, A., Rosenfeldt, L., Adams, G., Flick, M.J., Frederick, M., Palumbo, J. (2017) Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis. Poster presented at: American Society of Hematology (ASH); Atlanta, Georgia.
11. Remiker, A., Rosenfeldt, L., Adams, G., Flick, M.J., Frederick, M., Palumbo, J. (2018) Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis. Poster presented at: Thomas L. Boat Lecture Series; CCHMC.
12. Remiker, A. and Mullins, E. (2018) Successful Treatment with Mycophenolate Mofetil in Severe Hemophilia A Complicated by High Titer Inhibitor: A Case Report. Poster presented at: American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting; Pittsburgh, Pennsylvania.
13. Rankin, A., Badawy, S., Bennett, C.M., Buissereth, T., Campbell, K., Elkus, H., Grace, R.F., Remiker, A., Rifkin, S., Nakano, T.A. (2021) Standardizing the Diagnostic and Therapeutic Approach to Newly Diagnosed Children with ITP: An ITP Consortium of North America (ICON) Quality Improvement Initiative.