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CURRICULUM VITAE

Amadou K. Camara PhD
Professor
Department of Anesthesiology
Division of Research

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/1978 - 06/1982 B.A., Lawrence University, Appleton, WI (Adviser Dr. Bradford Rence
09/1984 - 06/1987 M.Sc., University of Wisconsin-Milwaukee, Milwaukee, WI (Adviser: Dr. Jonathan Cope
09/1990 - 05/1995 Ph.D., Medical College of Wisconsin, Milwaukee, WI (Adviser: Dr. Jeffrey L. O

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
08/1982 - 06/1983 Teaching Assistant Department of Biological Science Marquette University, Milwaukee WI
08/1984 - 05/1987 Teaching Assistant Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI
06/1987 - 05/1988 Research Assistant (Pain Research) the Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI (Supervisors: Dr. Liang F.
05/1988 - 05/1989 Research Technologist (Cardiac Arrhythmia) the Department of Pediatric Cardiology Medical College of Wisconsin, Milwaukee, WI (Supervisors: Dr. Dov Nudel, Dr. Marisa Jarenwattananon and
06/1989 - 08/1990 Research Technician (Renal Physiology) the Department of Physiology, Medical College of Wisconsin, Milwaukee WI (Supervisor: Dr.
02/1993 - 02/1995 Teaching Assistant Department of Physiology, Medical College of Wisconsin, Milwaukee, WI (Supervisor Dr. Richard Rom
06/1995 - 10/1999 Postdoctoral Fellow (Cardiac Electrophysiology) Department of Anesthesiology, Medical College of Wisconsin, Milwaukee WI. (Mentor: Dr. Ze

FACULTY APPOINTMENTS:
06/1985 - 08/1996 Associate Instructor Department of Allied Health and Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI (Summer Teaching)
11/1999 - 07/2003 Instructor Department of Anesthesiology
06/2000 - 07/2005 Instructor Department of Allied Health and Professions, University of Wisconsin-Milwaukee, Milwaukee, WI (Summer Instructor)
07/2003 - 07/2007 Assistant Professor Department of Anesthesiology
07/2007 - 06/2013 Associate Professor Department of Anesthesiology
07/2013 - Present Professor Department of Anesthesiology Medical College of Wisconsin, Milwaukee, WI
07/2017 - Present Adjunct Professor Institute of Clinical Medicine Suzhou Science & Technology Town Hospital, Suzhou China
02/2018 - Present Professor Department of Physiology Medical College of Wisconsin, Milwaukee, WI
07/2018 - Present Awarded Tenure at the full Professor level, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
04/1993 - Present NIH-NIDDK Travel Fellowship Award to attend the FASEB Meeting
05/1993 - 05/1995 NIH Minority Pre-Doctoral Graduate Research Assistant Supplement
04/1994 - Present The Procter and Gamble Professional Opportunity Award for Meritorious Research in "The Water and Electrolyte Homeostasis Section" of The American Physiological Society. Presentation: "Selective postna
04/1995 - Present NIH-NIDDK Travel Fellowship Award to attend the annual FASEB meeting
05/1995 - 05/1999 NIH-sponsored Minority Postdoctoral Fellowship Grant
04/1996 - Present NIH-NIDDK Travel Fellowship Award to attend the annual FASEB meeting

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
05/1993 - Present American Physiological Society (primary affiliate Cardiovascular Section and secondary affiliate Central Nervous System Section)
04/1995 - 2004 Society for Neuroscience
08/1996 - Present Biophysical Society
10/1997 - 2005 International Anesthesia Research Society
09/1998 - Present American Heart Association

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
1997 - Present American Journal of Physiology Heart and Circulatory Physiology
2010 - Present Reviewer for the Medical College of Wisconsin Clinical and Translational Science Institute (CTSI) Pilot Project Grants. The review panel is a multi-institutional panel of faculties from MCW, Marquette
2011 - Present Reviewing Editor for Antioxidants & Redox Signaling
2012 - Present Associate Editor for Frontiers in Mitochondrial Research, a subsection of Frontiers in Physiology
2013 - Present Reviewing Editor for a book chapter in "Systems Biology of Free Radicals and Anti-Oxidants" Edited by Dr. Ismail Laher, published by Springer-Verlag (Germany), copy right 2014
2014 - Present Guest Associate Editor for the Research Topic "Mitochondria: Hubs of cellular signaling, energetics and redox balance" for Frontiers in Physiology, Mitochondrial Research, 2014. Guest Editors include:
2014 - Present Reviewing Editor for a book proposal entitled "Mitochondrial Receptors: An Emerging Field" Edited by Dr. WF Maragos, published by Wiley Publishers, 111 River St. Hoboken, NJ 07030, USA
2015 - Present Reviewer for Medical College of Wisconsin Medical students' honors in research theses
2015 - Present Associate Editor Cardiovascular Genetics and Systems Medicine
2017 - Present Guest Associate Editor for the Research Topic "Genetic Modification of Cardiac Tissue" Frontiers for Cardiovascular Medicine, section Cardiovascular Genetics and Systems Medicine, 2017. Guest Editors
2018 - Present Member of the Editorial Board (Academic Editor) of "Oxidative Medicine and Cellular Longevity"
2019 - Present Guest Topic Editor Research Topic "Mitochondrial Exchangers and Transporters in Cell Survival and Death" Frontiers in Physiology-Mitochondrial Research, 2019. This Research Topic centers on the most r
2019 - Present Guest Topic Editor for the Special Issue "Mitochondria in Health and Disease for the journal Cells, 2019. This issue intends to highlight all aspects of mitochondrial metabolism and function under phy
2019 - Present Associate Editor for American Journal of Physiology Heart and Circulatory Physiology.
American Journal of Physiology Cell Physiology
American Journal of Physiology Regulatory, Integrative and Comparative Physiology
Journal of Pharmacology Biochemistry and Behavior
Current Alzheimer Research
Antioxidants & Redox Signaling
Pharmacological Research
Neurochemistry International
Heart International
International Journal of Molecular Science
PLoS ONE
Journal of General Physiology
Frontiers in Physiology-Mitochondrial Research
Pharmacology and Therapeutics (An International Review Journal)
Journal Molecular and Cellular Cardiology (JMCC)
Biochemi Biophysica Acta-Bioenergetics
Cardiovascular Research
Nature Reviews Cardiology
Hypertension
Faculty1000 Research
Frontiers in Pharmacology
Mitochondrion
Journal Cellular Molecular Medicine (JCMM)
Basic Research in Cardiology (BRC)
Oxidative Medicine and Cellular Longevity
Cellular Physiology and Biochemistry
Cells
Frontiers in Cardiovascular Medicine
Brain Research
European Journal of Pharmacology
International Journal of Molecular Sciences
LOCAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
Ad hoc journal reviewer:
Anesthesiology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
04/1 - 04/06/16 APS National Mentor Program. I mentored Dr. Tanecia Mitchell (APS
05/6 - 05/7 Department of Anesthesiology Visiting Professor Committee, Medical College of Wisconsin
08/6 - Present Evaluating Judge for SPUR and MSRTP/DSHREP Student Summer Research oral presentations, Medical College of Wisconsin
04/9 - 2015 Liaison between Medical College of Wisconsin Department of Physiology
07/9 - Present Member of the Anesthesiology Department Diversity Committee, Medical College of Wisconsin
11/9 - 2015 Member of the Department of Anesthesiology Visiting Professor Committee, Medical College of Wisconsin
03/10 - 2015 Member of the Biotechnology and Bioengineering Center T32 Internal
07/10 - Present Medical College of Wisconsin Admissions Committee (serves 5-7 hours of
09/10 - Present Evaluating judge for abstracts and poster presentations by medical student, graduate students, post-doctoral fellows, and junior faculty at the Medical College of Wisconsin Research Days
06/13 - 05/16 American Physiological Society (APS) Cardiovascular Section Fellowship
07/14 - Present American Physiological Society APS Porter Physiology Development and
05/16 - Present American Physiological Society Cardiovascular Section Awards Committee
09/16 - Present Member of the Anesthesiology Internal Committee for faculty evaluation and promotion, Medical College of Wisconsin
11/16 - Present Member of the MCW Advisory Board, Master of Science in Anesthesia in the department's Anesthesiology Assistant (AA) Program, Department of
07/17 - Present One of three moderators on a panel for the Cardiovascular Center (CVC)
04/21 - 04/28/18 APS National Mentor Program. I mentored Mr. Armand Meza Mitchell (APS
04/22 - 04/27/17 APS National Mentor Program. I mentored Oluwaseun Ogunbona, MD, a
02/2005 - Present Medical student admission interview for the MSTP program
06/2006 - Present Ad hoc member of the NIH Myocardial Ischemia and Metabolism (MIM) Study Section
06/2007 - 07/2011 Member of the NIH Myocardial Ischemia and Metabolism (MIM) Study Section
2010 - Present Ad hoc grant reviewer for the Austrian Science Fund (AWF)
09/2011 - Present NIH Special Emphasis Panel ZRG1 CVRS-F90, review of R15 grant applications for Cardiovascular and Respiratory Sciences
03/2012 - Present NIH Special Emphasis Panel ZRG1 CVRS-E (03) M for Myocardial Ischemia and Metabolism Study Section
09/2012 - 2018 Member of the American Heart Association's Cell Transport 2 Peer Review Study Group
2012 - Present Ad hoc grant reviewer for the Czech Science Foundation
11/2014 - 01/2018 Ad hoc grant reviewer for the American Physiological Society-Porter Fellowship Program
11/2014 - 01/2018 Reviewer for American Physiological Society-sponsored travel awards to attend regional, national and international physiology conferences
2014 - Present Ad hoc grant reviewer for the Medical Research Grant Committee of Dubai, UAE
2015 - Present Ad hoc grant reviewer for the National Science Centre of Poland
2015 - Present Ad hoc grant reviewer for the National Science Centre of Poland
2016 - Present Ad hoc grant reviewer for the National Institute of Academic Anesthesia (NIAA e-grants) England, sponsored by the British Journal of Anesthesia (BJA) and The Royal College of Anesthetists (RCA)
10/18/2017 - 18 External grant reviewer for the Pauley Heart Center at Virginia
02/2018 - Present Interviewed Anesthesiology prospective residents
03/2018 - Present Ad hoc grant reviewer for the William Myron Keck foundation, Los Angeles, California, an American Charitable foundation that seeks out scientific research that opens new directions and could lead to breakthrough discoveries or the development of new technologie, the grant program seeks to support high-impact and high-risk projects that are scientifically outstanding.
06/2018 - Present Appointed by the Dean of the School of Medicine, the Medical College of Wisconsin, to serve on the Chair of Family and Community Medicine Search Committee
08/2018 - Present Appointed as a Standing Member of the Medical Students Summer Research Program (MSSRP) Advisory Committee, Medical College of Wisconsin, Milwaukee
11/2018 - Present Temporal member on NIH Mentored Transition to Independence (MTI) K99/R00 and K22 grant applications (NHLBI-MTI)
2019 - Present Ad hoc grant reviewer for the Medical Research Council (MRC) equivalent to NIH, United Kingdom
underrepresented minority participation in physiology and other scientific
disciplines.
Member. Currently involve in evaluating nominees for an outstanding
Physiologist who has made a significant contribution to physiology.
member) of the University of Alabama, Birmingham, during the Experimental
Biology (APS member) attendee, during the 2016 Experimental Biology
Grant Reviews:
meeting Conference in San Diego, California.
PhD candidate in the Cellular and Molecular Physiology (CMP) Program
Johns Hopkins University School of Medicine during the 2017 Experimental
Biology, in meeting Chicago, IL.
University of Wisconsin, Madison, during the Experimental Biology (APS
member) attendee, during the 2018 Experimental Biology Conference in San
Diego, California.
Commonwealth university.
Medical College of Wisconsin Committees
and University of Wisconsin-Milwaukee, Marquette University and the
Milwaukee Area Technical College to recruit qualified and highly motivated
minority/underrepresented students to the Department of Physiology graduate
school program
Advisory Committee
volunteering service weekly for screening applications and reviewing files for interviews). I was one of two committee members (approximately 25 members) recognized with a plaque for excellence and de
Department of Anesthesiology
Anesthesiology
Study/Work in Progress discussion and provide feedback on a potential grant for submission; the research included some aspects on the role of mitochondria.
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE
POSITIONS:
and Spring to formulate strategies and policies on how to increase
Minority Affairs Committee Member. Attend APS policy meetings in the Fall
of APS.
Committee Member. Duties included evaluation of APS members for Fellow
National Committees and Services
COMMITTEES/SERVICE
member), a graduate student in the Department of Neuroscience, of the

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
06/01/2005 - 08/01/2005 Mentor to Christopher Johnson of the University of Wisconsin at
05/30/2006 - 08/01/2006 Mentor to Christopher Johnson of the University of Wisconsin
06/01/2008 - 08/05/2008 Co-Mentor to Emmanuel Ofungwu in his project examining the
Cardiovasc Pharmacol 52:236-244, 2008 - Present (PMID: 18806604).
06/01/2010 - 08/04/2010 Mentor to Linda Thomas an undergraduate student from
06/01/2017 - 08/04/2017 Co-Mentor: Andrew Sobczak is a senior undergraduate at Drake University Project title: "Consequence of VDAC Modulation on Cardiac Mitochondrial Respiration". This project aims to examine novel aspects of VDAC modulations of mitochondrial bioenergetics and Ca2+ handling by its activators and blockers.
Stevens Point was a candidate for the Multicultural Summer Research Training Program (MSRTP).
His project title was: "Post-conditioning in cardioprotection: The role of mitochondrial big calcium
sensitive potassium channels." I spent most of my time teaching and training Chris about his
project. In this effort, I also helped in the design of his protocols and data interpretations.
Stevens Point in his second MSRTP participation in our laboratory. He continued to work on the
project he started in 2005. In addition to providing him with some help on his research project, I
also, tutored him on the significance of mitochondria and the regulation of matrix Ca2+ dynamics
and how these processes pertain to cardiac ischemia and reperfusion injury.
05/30/2006-08/01/2006 Mentor to Marisha Spence, a senior at the University of Wisconsin
Milwaukee. I supervised during her participation in the 2006 Multicultural Summer
Research Training Program (MSRTP). Her summer project title: Sodium-Hydrogen exchange
inhibitor and protection of mitochondrial bioenergetics against warm ischemia and reperfusion.
This work contributed to another project we were conducting and became part of a publication in J
feasibility of hypothermic post-conditioning, specifically the role mitochondria play during
hypothermic cardioprotection. I assisted Emmanuel in the entirety of his project in our lab.
Emmanuel recently graduated from Ross Medical School in Chicago.
the University of St Thomas, St Paul, MN. Her project was to determine the efficacy of the ROS
Scavenger Resveratrol and the mild mitochondrial complex I blocker ranolazine in protecting the
heart against ischemia and reperfusion injury in the Langendorff model. Poster title: Resveratrol
and mild hypothermia provides similar protection against post ischemia reperfusion injury in the
isolated guinea pig heart. Linda Thomas is pursuing a graduate study in Biochemistry.
6/01/2013-08/01/2013 Mentor to Dehja Brown, Howard University. Project title: Modulation
of Mitochondrial Functions and Ca2+ Homeostasis by Isoflurane under Physiological and
Pathophysiological Conditions. Dehja graduated from Howard University and is currently pursuing
a career in nurse practitioner College of Wisconsin Diversity Summer Health-related Research
Education Program.
6/01/2016-8/04/2016 Mentor to Ebony Carson (UW-Madison). Project title: Modulation of the putative mitochondrial ryanodine-like channels alters mitochondrial bioenergetics and matrix Ca2+ handling. This project focuses on mitochondrial Ca2+ uptake and regulation, and the modulatory effect of the putative mitochondrial ryanodine like receptors (mRyR) on these processes. Ebony currently works at the MCW Cancer Center.
6/01/2017-8/04/2017 Mentor to Bernice Badu is now an MCW M1. Project title: Characterizing and comparing mitochondrial calcium dynamics in H9C2 cell lines and human (diabetic and nondiabetic) iPSC-derived cardiomyocytes and the modulating role of glycemic condition and volatile anesthetics. This project focused on mitochondrial Ca2+ uptake and regulation under hyperglycemic and normal glucose conditions, and the modulatory effect of isoflurane. This research endeavor was sponsored by MCW.
Summer Program for Undergraduate Research (SPUR) Undergraduate Students
 
Graduate Students
MS Committees
1 - Present Introduction to Physiology: General Models in Physiology
3 - Present Anatomy and Physiology of the Central Nervous System
4 - Present Physiology of the Autonomic Nervous System
5 - Present Cardiovascular: Overview of Circulation and Hemodynamics
6 - Present Nervous Regulation of the Circulation and Rapid Control of Arterial Pressure; Cardiac Output Regulation: The Heart
11 - Present Renal: Tubular Transport II; Urinary Concentration and Dilution
responsible for teaching a significant portion of the Fall Physiology course. I lecture 11 courses @ 2
hours/lecture).
Lectures:
2. Transmembrane H2O Flux, Synaptic Transmission
9. Renal: Kidney Physiology, Composition of Body Fluids, Glomerular Filtration Rate (GFR) I, Renal Blood Flow I
10. Renal: GFR II, Renal Blood Flow II, and Renal Tubular Transport I
EDUCATION SERVICE AT OTHER INSTITUTIONS:
University of Wisconsin-Milwaukee
MA Committees
2 - Present Role of Mitochondria in Cancer
2010 - Present Course Director M3-Electives in Anesthesiology Research Department. Course
improves Angiogenesis in Persistent Pulmonary Hypertension of the Newborn. Adviser
Dr. Girija G Konduri (Chief and Professor Department of Neonatology, Medical College of
mitochondria guided me throughout this process; his discussion, ideas, and feedback have been
absolutely invaluable."
TEACHING AT THE MEDICAL COLLEGE OF WISCONSIN:
Graduate and Medical Education
Ion Channel Course. I lecture two courses and lead one group discussion with the graduate students.
Each lecture and group discussion is 2 hours long.
Lectures:
1. Ion channels, exchangers, transporters and pumps-cell membrane and mitochondrial membranes
Title: "Mitochondrial Signaling in Cardioprotection" Course number ANES-D3349. Course
objectives: Students learn the fundamental tools on how to conduct basic research in cardiovascular
anesthesia. Focus in my lab will be how to design and execute experimental protocols relating to
mitochondrial studies in the whole organ, isolated cells and isolated mitochondria in the context of
anesthetic effect.
Professor Department of Engineering, UW-Milwaukee. Part of her dissertation has led to a joint
publication see Bibliography reference #81).
processing for quantitative analysis of metabolic states in different disease models. Her project:
of her project has been reviewed and accepted for publication (see Bibliography reference #83).
Biomedical Engineering program
Brown Deer High School
See description below, after Bibliography.
PhD Committees
Department of Engineering, dissertation committee. Dissertation title: Quantitative optical studies
Engineering, Biophotonics Lab, UW-Milwaukee. The objective of her research is to develop and
title: Thermodynamically-Constrained Computational Modeling of Lung Tissue Bioenergetics and
the Effect of Hyperoxia-Induced Acute Lung Injury. "Adviser Dr. Said Audi (Professor of
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Tseng L-F, Tang R, Stackman R, Camara A, and Fujimoto JM. Brainstem sites differentially sensitive to -endorphin and morphine for analgesia and release of met-enkephalin in anesthetized rats. J Pharmacol Exp Ther 253: 930-937, 1990 (PMID: 2141638).
2. Nudel DB, Camara A, and Levine M. Comparative effects of bicarbonate, Tris (hydroxymethyl)aminoethane and dichloroacetate in newborn swine with normoxic lactic acidosis. Dev Pharmacol and Ther 20: 20-25, 1993 (PMID: 7924761).
3. Osborn JL, and Camara AKS. Renal neurogenic mediation of ICV AII hypertension in rats raised on high sodium chloride diet. Hypertension 30(1): 331-336,1997 (PMID: 9314413).
4. Camara AKS, and Osborn JL. AT1 receptors mediate chronic central nervous system AII hypertension in rata fed high sodium chloride diet from weaning. J Auton Nerv Syst 72: 16-23,1998 (PMID: 9760076).
5. Camara AKS, and Osborn JL. -Adrenergic receptors mediate chronic central AII hypertension in rats raised on high sodium chloride diet from weaning. J Auton Nerv Syst 76(1): 28-34,1999 (PMID: 10323304).
6. Camara AKS, and Osborn JL. Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II-induced drinking in rats fed high sodium chloride diet from weaning. Acta Physiol Scand 171 (2): 195-201, 2001 (PMID: 11350280).
7. Camara AKS, Begic Z, Kwok W-M, and Bosnjak ZJ. Differential modulation of the cardiac L- and T-type calcium channels by isoflurane. Anesthesiology 95: 515-524, 2001 (PMID: 11506128).
8. Camara AKS, Turner LA, and Bosnjak ZJ. Interactions of halothane with isoproterenol and epinephrine on canine epicardial conduction velocity at normal and elevated potassium levels. Acta Anesthesiol Scand 45(7): 885-892, 2001 (PMID: 11472292).
9. An JZ, Varadarajan SG, Camara A, Chen Q, Novalija E, Gross GJ, and Stowe DF. Blocking Na+/H+ exchange reduces [Na+]i and [Ca2+]i load after ischemia and improves function in intact hearts. Am J Physiol Heart Circ Physiol 281: H2398-H2409, 2001 (PMID: 11709405).
10. Stowe DF, Heisner JS, An JZ, Camara AKS, Varadarajan SG, Novalija E, Chen Q, and Schelling P. Inhibition of Na+/H+ exchange-1 isoform protects hearts reperfused after six-hour cardioplegic cold storage. J Heart Lung Transplant 21(3): 374-382, 2002 (PMID: 11897527).
11. Chen Q, Camara AKS, An JZ, Riess ML, Novalija E, and Stowe DF. Cardiac preconditioning with 4 hr, 17˚C ischemia reduces [Ca2+]i load and damage in part via KATP channel opening. Am J Physiol Heart Circ Physiol 282(6): H1961-H1969, 2002 (PMID: 12003799).
12. Riess ML, Camara AKS, Chen Q, Novalija E. Rhodes SS, and Stowe DF. Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts. Am J Physiol Heart Circ Physiol 283: H53-H60, 2002 (PMID: 12063274).
13. Novalija E, Varadarajan SG, Camara, AKS, An JZ, Chen Q, Riess, ML, Hogg N, and Stowe DF. Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts. Am J Physiol Heart Circ Physiol 283: H44-H52, 2002 (PMID: 12063273).
14. Chen Q, Camara AKS, An JZ, Novalija E, Riess ML, and Stowe DF. Sevoflurane preconditioning prior to moderate hypothermic ischemia protects against cytosolic [Ca2+] loading and myocardial damage in part via mitochondrial KATP channels. Anesthesiology 97(4): 912-920, 2002 (PMID: 12357159).
15. Riess ML, Camara AKS, Novalija E, Chen Q, Rhodes SS, and Stowe DF. Anesthetic preconditioning attenuates mitochondrial [Ca2+] accumulation during ischemia by triggering mitochondrial KATP channel opening in guinea pig intact hearts. Anesth Analg 95(6): 1540-1546, 2002 (PMID: 12456413).
16. Camara AKS, An JZ, Chen Q, Novalija E, Varadarajan SG, Schelling P, and Stowe DF. Na+/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and damage after cold ischemia. J Cardiovasc Pharmacol 41(5): 686-698, 2003 (PMID: 12717098).
17. Kevin LG, Camara AKS, Riess ML, Novalija E, and Stowe DF. Ischemic preconditioning alters real-time measures of O2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol 284: H566-H574, 2003 (PMID: 12414448).
18. Kevin LG, Novalija E, Riess ML, Camara AKS, Rhodes, SS, and Stowe, DF. Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth Analg 96(4): 949-955, 2003 (PMID: 12651639).
19. Riess ML, Novalija E, Camara AKS, Eells JT, Chen Q, and Stowe DF. Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in hearts: reversal by 5-hydroxydecanoic acid. Anesthesiology 98(2): 387-395, 2003 (PMID: 12552198).
20. Rhodes SS, Ropella KM, Camara AKS, Kevin LG, Riess ML, and Stowe DF. Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LVP pressure at 17°C, and after 37°C and 17°C ischemia. Am J Physiol Heart Circ Physiol 284: H1217-H1229, 2003 (PMID: 12531735).
21. An JZ, Camara AKS, Chen Q, and Stowe DF. Effect of low [CaCl2] and high [MgCl2] cardioplegia and moderate hypothermic ischemia on myoplasmic [Ca2+] and cardiac function in intact hearts. Eur J Cardiothorac Surg 24(6): 974-985, 2003 (PMID: 14643817).
22. Novalija E, Kevin LG, Camara AKS, Bosnjak, ZB, Kampine, JP, and Stowe DF. Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning cascade. Anesthesiology 99: 421-428, 2003 (PMID: 12883415).
23. Rhodes SS, Ropella KM, Camara AKS, Chen Q, Riess ML, and Stowe DF. How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts. J Cardiovasc Pharmacol 42(4): 539-553, 2003 (PMID: 14508241).
24. Kevin LG, Katz, P, Camara AKS, Novalija, E., Riess, ML., and Stowe DF. Anesthetic preconditioning: effects on latency to ischemic injury in isolated hearts. Anesthesiology 99: 385-391, 2003 (PMID: 12883411).
25. Novalija E, Hogg N, Kevin LG, Camara AKS, and Stowe DF. Ischemic preconditioning: triggering role of nitric oxide-derived oxidants in isolated hearts. J Cardiovasc Pharmacol 42(5): 593-600, 2003 (PMID: 14576506).
26. Chen Q, Camara AKS, Rhodes SS, Riess ML, Novalija E, and Stowe DF. Cardiotonic drugs differentially alter cytosolic [Ca2+] to LVP relationship before and after ischemia in intact guinea pig hearts. Cardiovasc Res 59: 912-925, 2003 (PMID: 14553831).
27. Camara AKS, Kevin LG, Riess ML, Novalija E, and Stowe DF. Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart. Am J Physiol Heart Circ Physiol 286: H1289-H1299, 2004 (PMID: 14644763).
28. Riess ML, Camara AKS, Kevin LG, and Stowe DF. Hypothermia preserves mitochondrial NADH and prevents Ca2+ overload and excess ROS formation during ischemia in intact hearts. Cardiovasc Res 61: 580-590, 2004 (PMID: 14962488).
29. Riess ML, Kevin LG, Camara AKS, Heisner JS, and Stowe DF. Dual exposure to sevoflurane improves anesthetic preconditioning in intact hearts. Anesthesiology 100: 569-574, 2004 (PMID: 15108970).
30. Riess ML, Eells JT, Kevin LG, Camara AKS, Henry MM, and Stowe DF. Attenuation of mitochondrial respiration by sevoflurane in isolated cardiac mitochondria is mediated in part by reactive oxygen species. Anesthesiology 100: 498-505, 2004 (PMID: 15108961).
31. Camara AKS, Chen Q, An JZ, Novalija E, Rhodes SS, Riess ML, and Stowe DF. Comparison of hyperkalemic cardioplegia with varied Ca2+ and Mg2+ concentrations on [Ca2+]i transients and function after global ischemia in isolated hearts. J Cardiovasc Surg 45(1): 1-13, 2004 (PMID: 15041929).
32. Kevin LG, Katz P, Camara AKS, Novalija E, Riess ML, and Stowe, DF. Anesthetic preconditioning versus anesthetic treatment: effects on ischemic injury in isolated hearts. Anesthesiology 100: 1327-1328, 2004 DOI: 10.1097/00000542-200405000-00052)-Author response (PMID: 15114246).
33. Camara AKS, Chen Q, Rhodes SS, Riess ML, and Stowe DF. Negative inotropic drugs alter indices of cytosolic [Ca2+]-left ventricular pressure relationships after ischemia. Am J Physiol Heart Circ Physiol 287: H667-H680, 2004 (PMID: 15059780).
34. An JZ, Camara AKS, Rhodes SS, Riess ML, and Stowe DF. Improved mitochondrial bioenergetics during and after mild hypothermic ischemia with prior ischemic preconditioning. Am J Physiol Heart Circ Physiol 287: H2620-H2627, 2005 (PMID: 15653757).
35. An JZ, Camara AKS, Riess ML, Rhodes SS, Varadarajan SG, and Stowe DF. Improved mitochondrial bioenergetics by anesthetic preconditioning during and after 2 hours of 27°C ischemia in isolated hearts. J Cardiovasc Pharmacol 46(3): 280-287 2005 (PMID: 16116332).
36. Riess ML, Camara AKS, Rhodes SR, McCormick J, and Stowe DF. Increasing heart size and age attenuate anesthetic preconditioning in guinea pig isolated hearts. Anesth Analg 101: 1572-1576, 2005 (PMID: 16301221).
37. Stowe DF, Aldakkak M, Camara AKS, Riess ML, Heinen A, Varadarajan SG, and Jiang MT. Cardiac mitochondrial preconditioning by big Ca2+-sensitive K+ channel opening requires superoxide radical generation. Am J Physiol Heart Circ Physiol 290: H434-H440, 2006 (PMID: 16126810).
38. Rhodes SS, Ropella KM, Camara AKS, Chen Q, Riess ML, Pagel PS, and Stowe, DF. Ischemia reperfusion injury changes the dynamics of Ca2+ handling and contraction coupling due to inotropic drugs in isolated hearts. J Appl Physiol 100: 940-950, 2006 (PMID: 16282437).
39. Rhodes SS, Camara AKS, Ropella KM, Audi S, Riess ML, Pagel PS, and Stowe DF. Ischemia reperfusion injury changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts. BioMedical Engineering OnLine, 5: 162006 (PMID: 16512898).
40. Heinen A, Camara AKS, Aldakkak M, Rhodes SS, Riess ML, and Stowe DF. Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential. Am J Physiol Cell Physiol 292: C148-C156, 2007 (PMID: 16870831).
41. Camara AKS, Aldakkak M, Heisner JS, Rhodes SS, Riess ML, An JZ, Heinen A and Stowe, DF. ROS scavenging before 27°C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state. Am J Physiol Cell Physiol 292: C2021-C2031, 2007 (PMID: 17287367).
42. Huang M, Camara AKS, Stowe DF, Qi F, and Beard DA. Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence. Annals of Biomedical Engineering 35: 1276-1285, 2007 (PMID: 17372838)
43. Stowe DF, Camara AKS, Heisner J, Aldakkak M and Harder DR. Ten-hour preservation of guinea pig hearts perfused at low flow with air-saturated Lifor solution at room temperature: Comparison to ViaSpan. Am J Physiol Heart Circ Physiol 293:895-901, 2007 (PMID: 17489396).
44. Heinen A, Aldakkak M, Stowe DF, Rhodes SS, Riess ML, Varadarajan GV, and Camara AKS. Reversed electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+ sensitive potassium channels. Am J Physiol Heart Circ Physiol. 293:H1400-7, 2007 (PMID: 17513497).
45. Aldakkak M, Stowe DF, Chen Q, Lesnefsky EJ, and Camara AKS. Inhibited mitochondrial respiration by amobarbital during ischemia improves redox state and reduces matrix Ca2+ overload and release of ROS. Cardiovasc Res. 77:406-415, 2008 (PMID: 17900548).
46. Riess ML, Camara AKS, Heinen A, Eells JT, Henry MM, and Stowe DF. KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol 51:483-491, 2008 (PMID: 18437094).
47. Stowe DF, Camara AKS, Heisner J, Aldakkak M and Harder DR. Low flow perfusion of guinea pig isolated hearts with 26°C air-saturated Lifor® solution for 20 h preserves cardiac function. J Heart and Lung Transplant 27:1008-125, 2008 (PMID: 18765194).
48. Aldakkak M, Stowe DF, Heisner JS, Spence M, and Camara AKS. Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function. J Cardiovasc Pharmacol 52:236-244, 2008 (PMID: 18806604).
49. Aldakkak M, Stowe DF, Lesnefsky EJ, Heisner JS, Chen Q, and Camara AKS. Modulation of mitochondrial bioenergetics in isolated beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. J Cardiovasc Pharmacol 54:298-309, 2009 (PMID: 19620879).
50. Riess ML, Rhodes SS, Stowe DF, Aldakkak M, and Camara AKS. Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts. J Pharmacol and Toxicol Methods 60:275-280, 2009 (PMID: 19706331).
51. Aldakkak M, Stowe DF, Cheng Q, Kwok W-M, and Camara AKS. Mitochondrial matrix K+ flux independent of large conductance Ca2+ activated K+ channel opening. Am J Physiol Cell Physiol 298:C530-C541, 2010 (PMID: 20053924).
52. Sedlic F, Sepac A, Pravdic D, Camara AKS, Bienengraeber, Brzezinska AK, Wakatsuki T and Bosnjak Z. Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+, Am J Physiol Cell Physiol, 299:C506-C599, 2010 (PMID: 20519447).
53. Sedlic F, Pravdic D, Mio Y, Sepac A, Wakatsuki T, Camara AKS, Bosnjak Z, and Bienengraeber M. Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes. Biochemic et Biophys Acta, 1797:1749-1758, 2010 (PMID: 20646994).
54. Haumann J, Dash RK, Stowe DF, Boelens A, Beard DA, and Camara AKS. Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: Exploration of mechanisms. Biophysical Journal, 99: 997-1006, 2010 (PMID: 20712982).
55. Aldakkak M, Camara AKS*, Heisner JS, Yang M, and Stowe DF*. Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res 64: 381-392, 2011 (PMID: 21741479) *equal responsibilities as corresponding/senior author.
56. Aldakkak M, Stowe DF, Heisner JS, Riess ML, and Camara AKS. Adding ROS quenchers to K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia. J Cardiovasc Pharmacol Ther 17: 94-102 2012 (PMID: 21282477).
57. Gadicherla AK, Stowe DF, Antholine W, Yang M, and Camara AKS. Damage to mitochondrial complex I during cardiac ischemia and reperfusion injury is reduced by anti-anginal drug ranolazine. Biochim Biophys Acta-Bioenerg 1817: 419-429, 2012 (PMID: 22178605).
58. Agarwal B, Camara AKS, Stowe DF, and Dash RK. Isoflurane increases mitochondrial free Ca2+ in response to Ca2+ and ADP by enhancing transport via the Ca2+ uniporter and decreasing ADP-induced NADH oxidation. Biochemi Biophys Acta-Bioenerg 1817 (3): 453-465, 2012 (PMID: 22155157).
59. An JZ, Du J, Wei N, Tongju G, Camara AKS, and Shi Y. Differential sensitivity to LPS-induced myocardial dysfunction in the isolated brown Norway and Dahl S rat hearts: role of mitochondrial function, NFB activation and TNF- production. Shock 37: 325-32, 2012 (PMID: 22089203).
60. Rhodes SS, Camara AKS, Heisner JS, Riess ML, Aldakkak M, and DF, Stowe. Reduced mitochondrial Ca2+ loading and improved functional recovery after ischemia reperfusion injury in old vs. young guinea pig hearts. Am J Physiol Heart-Circ Physiol 302: H855-63, 2012 (PMID: 22140052).
61. Yang M, Camara AKS, Wakim BT, Zhuo I, Gadicherla AK, Kwok W-M, and Stowe DF. Specific tyrosine nitration of voltage dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging. Biochim Biophys Acta-Bioenerg, 18177: 2049-2059, 2012 (PMID: 22709907).
62. Stowe DF, Gadicherla AK, Jiang MT, Aldakkak M, Zhou Y, Kwok W-M, Heisner JS, Yang M, and Camara AKS. Protection against cardiac injury by small Ca2+-sensitive K+ channels identified in guinea pig cardiac inner mitochondrial membrane. Acta Biochemi Biomemb 1828:427-442, 2013 (PMID: 22982251).
63. Aldakkak M, Stowe DF, Dash RK, and Camara AKS. Mitochondrial handling of excess Ca2+ is substrate dependent with implications on ROS generation. Free Radic Biol Med, 56:193-203, 2013 (PMID: 23010495)
64. Blomeyer CA, Bazil JN, Stowe DF, Pradhan RK, Dash RK, and Camara AKS. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Biomembr Bioenerg 45(3):189-202, 2013 (PMID: 23225099).
65. Bazil JN, Blomeyer CA, Pradhan RK, Camara AKS, and Dash RK. Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria. J Biomembr Bioenerg 45(3):177-88, 2013 (PMID: 23180139).
66. Boelens AD, Pradhan RK, Bolmeyer C, Camara AKS, Dash RK, and Stowe DF. Extra-matrix Mg2+ limits mitochondrial Ca2+ uptake and Ca2+-induced and Ca2+-independent respiration and redox state. J Biomembr Bioenerg 45(3):203-18, 2013 (PMID: 23456198)
67. Du J, Li Z, Li Q, Guan T, Yang Q, Pritchard KA, Camara AKS and Shi Y. Enoyl CoA hydratase domain-containing 2, a potential novel regulator of myocardial ischemia injury J Am Heart Assoc. 9;2(5): e000233, 2013 (PMID: 24108764).
68. Pannala V, Bazil JN, Camara AKS, and Dash RK. A biophysically-based mathematical model for the catalytic mechanism of glutathione reductase. Free Radic Biol Med 65:1385-1397, 2013 (PMID: 24120751).
69. Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ and Camara AKS. Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochemi Biophys Acta-Bioenerg 1837:354-365, 2014 (PMID: 24355434).
70. Pannala V, Bazil JN, Camara AKS, and Dash RK. A mechanistic mathematical model for the catalytic action of glutathione peroxidase Free Radic Res, 48: 487-502, 2014 (PMID: 24456207).
71. Tewari S, Camara AKS, Stowe DF, and Dash RK. Computational analysis of Ca2+ dynamics in isolated mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol. 592: 1917-30, 2014 (PMID: 24591571).
72. Yang M, Stowe DF, Udoh KB, Heisner JS, and Camara AKS. Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia. PLoS One. 9(12): e113534, 2014 (PMID: 25436907).
73. Lindsay DP, Camara AKS, Lubbe R, Stowe DF, and Aldakkak M. Differential effects of buffer pH on Ca2+-induced ROS emission from mitochondrial complexes I and III. Front Physiol 6:58. doi: 10.3389/fphys.2015.00058, 2015 (PMID: 25805998).
74. Note: A commentary on this article was provided by Javadov S. Front Physiol. 2015 6:83. doi: 10.3389/fphys.2015.00083. eCollection 2015 (PMID: 25852570 PMCID: PMC436417)1
75. Rhodes SS, Camara AKS, Aldakkak M, Heisner JS, and Stowe DF. Stretch-induced increase in cardiac contractility is independent of myocyte Ca2+ while block of stretch channels by streptomycin improves contractility after ischemic stunning. Physiol Rep. e12486. doi: 10.14814/phy2.12486 2015 (PMID: 26290532).
76. Blomeyer CA, Bazil JN, Dash RK, Stowe DF, and Camara AKS. Mg2+ differentially regulates two modes of mitochondrial Ca2+ uptake in isolated cardiac mitochondria: Implications for mitochondrial Ca2+ sequestration. J Bioenerg Biomembr. 48(3): 175-88, 2016 (PMID: 26815005)
77. Ranji M*, Salehpour F, Motlagh MM, Sepehr R, Heisner JS, Dash RK, and Camara AKS*. Optical cryoimaging reveals a heterogeneous distribution of mitochondrial redox state in ex vivo guinea pig hearts and its alteration during ischemia and reperfusion. J. Trans Engineering Health Med 15;4:1800210. doi: 10.1109/JTEHM.2016.2570219, 2016 (PMID: 27574574). *shared equal responsibility as corresponding authors.
78. Note: This article was featured and editorialized by the Chief Clinical Editor of J. Trans Eng Health Med for its novel findings. See link http://health.embs.org/
79. Pannala V, Camara AK, and Dash RK. Modeling the detailed Kinetics of mitochondrial cytochrome c oxidase: catalytic mechanism and nitric oxide inhibition. J. Appl Physiol. 121(5): 1196-1207, 2016 (PMID: 27633738)
80. Yang M, Camara AKS, Aldakkak M, Kwok WM and Stowe DF. Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel variant. Biochim Biophys Acta- Bioenerg. 1858 (6): 442-458, 2017 (PMID: 28342809).
81. Audi SH, Jacobs ER, Zhang X, Camara AK, Zhao M, Rizzo B, Medhora M, Clough AV. Protection by inhaled hydrogen therapy in a rat Model of Acute Lung Injury can be tracked using molecular imaging. 48(4):467-476. doi: 10.1097/SHK.0000000000000872. Shock, 2017 (PMID: 28915216).
82. Gadicherla AK, Wang N, Bulic M, Agullo-Pascual E, Lissoni A, De Smet M, Delmar M, Bultynck G, Krysko D, Camara A, Schlüter K-D, Schulz R, Kwok WM, Leybaert L. Mitochondrial Cx43 forms hemichannels contribute to calcium entry and cell death in the heart. Basic Res in Cardiol. 112(3): 27, 2017 doi: 10.1007/s00395-017-0618-1 (PMID: 28364353).
83. Stowe DF, Yang M, Heisner JS, and Camara AKS. Endogenous and agonist-induced opening of mitochondrial big vs. small Ca2+-sensitive K+ channels on cardiac cell and mitochondrial protection. J. Cardiovasc Pharmacol, 70(5):314-328 doi: 10.1097/FJC.0000000000000524, 2017 (PMID: 28777255).
84. La Cour MF, Mehrvar S, Heisner JS, Motlagh MM, Medhora M, Ranji M*, Camara AKS*. Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury. J Biomed Opt. 23(1):1-9. doi: 10.1117/1.JBO.23.1.016011, 2018 (PMID: 29352564) *Shared equal responsibility as corresponding author.
85. Zhang X, Dash RK, Jacobs ER, Camara AKS, Clough AV, Audi SH. Thermodynamically-constrained computational model of lung mitochondrial bioenergetics. PLoS One. Jun 11;13(6):e0197921. doi: 10.1371, 2018 (PMID: 29889855).
86. Yang M, Kwok WM, Yanji X, Heisner JS, Stowe DF, and Camara AKS. Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria. Mitochondrion 46: 380-392, 2019 doi: 10.1016/j.mito.2018.10.002. (PMID: 30391711).
87. Ghanian Z, Kondouri G, Audi S, Camara AKS*, Mahsa Ranji*. Quantitative optical measurement of mitochondrial superoxide dynamics in pulmonary artery endothelial cells. J Innov Opt Hlth Sci. 11 (1): 1-16, 2018. DOI: 10.1142/S1793545817500183 (PMID: 30123329) *Shared equal responsibility as corresponding author.
88. Haumann J, Camara AKS, Gadicherla AK, Navarro CD, Boelens AD, Blomeyer CA, Kwok WM, Boswell MR, Dash RK and Stowe DF. Slow Ca2+ efflux in partially depolarized cardiac mitochondria: role of MCU and F0F1-ATPase to modulate Ca2+/H+ exchange. Front Physiol. Mitochondrial Research 2019 9:1914. doi: 10.3389/fphys.2018.01914. eCollection (PMID: 30804812).
89. Mehrvar S, la Cour MF, Medhora M, Camara AKS*, and Ranji M*. Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril. Ann Biomed Eng. [Epub ahead of press] 2019 doi: 10.1007/s10439-019-02255-8 (PMID: 30963380) *Co-senior authors and corresponding authors.
90. Ait-Aissa K, Heisner JS, Bruemmer DC, Harmann L, Geurts A, Camara AK, Beyer AM. Telomerase deficiency predisposes to heart failure and ischemia and reperfusion injury Front Cardiovasc Med. 2019 2;6:31. doi: 10.3389/fcvm.2019.00031. eCollection 2019. (PMID: 31001540).
91. Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AK, Gutterman DD, Donato AJ, Porter GA, and Beyer AM. Mitochondrial oxidative phosphorylation defect in the Heart of Subjects with Coronary Artery Disease. Scientific Report 9(1):7623. doi: 10.1038/s41598-019-43761-y, 2019. (PMID: 31110224).
92. Mishra J, Davani AJ, Krishnamoorthy G, Stowe DF, Kwok WM, and Camara AKS. Cyclosporin A increases mitochondrial buffering of calcium: an additional mechanism in delaying mitochondrial permeability transition pore opening. Cells, 7;8(9). pii: E1052. doi: 10.3390/cells8091052, 2019 (PMID: 31500337). At the time of publication, this article was recognized as a Feature Article in 24 articles contributed to the special topic "Mitochondria in Health and Disease".
93. Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Tahiri A, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Kristensen VN, Mills GB, Pradeep S, Chaluvally-Raghavan P. miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. Cell Rep.; 29(13):4389-4406.e10. doi: 10.1016/j.celrep.2019.11.085, 2019. (PMID: 31875548)
94. Wang C, Qiao S, Hong L, Sun J, Che T, An J*, Camara AKS*. NOS cofactor tetrahydrobiopterin contributes to anesthetic preconditioning induced myocardial protection in the isolated rat heart Int J of Mol Med. 45(2):615-622. doi: 10.3892/ijmm.2019.4445, 2020 (PMID: 31894305). *Shared equal responsibility as corresponding author.
95. Riess ML, ElOrbany R, Weihrauch D, Stowe DF, and Camara AKS. PPAR-independent side effects of Thiazolidinediones on mitochondrial redox state in rat isolated hearts. Cells. 20;9(1). pii: E252. doi: 10.3390/cells9010252, 2020 (PMID: 31968546). Special topic: "Mitochondria in Health and Disease".
96. Schlaak RA, Frei A, SenthilKumar G, Tsaih S-W, Wells C, Mishra J, Flister MJ, Camara AKS and Bergom C. Differences in expression of mitochondrial complexes due to genetic variants may alter sensitivity to radiation-induced cardiac dysfunction. Front. Cardiovasc. Med. Vol 7(23), doi: 10.3389/fcvm.2020.00023 (PMID: 32195269), 2020. Brief Research Report on Cardio-Cardio-Oncology; Special Topic: "Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside", accepted with minor revisions, 2020.
97. Glait L*, Natarajan GK*, Mishra J, Stowe DF, Camara AK, and Kwok WM. Total Matrix Calcium modulates calcium efflux via the calcium-hydrogen exchanger in cardiac mitochondria. Submitted to Frontiers in Physiology- Mitochondrial Research; Special topic: "Mitochondrial Exchangers and Transporters in Cell Survival and Death", 2020 (currently under revision). *Equal contribution as first author
98. Gerdes HJ*, Yang M*, Heisner JS, Camara AKS and Stowe DF. Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca2+ and succinate-induced oxidative stress in cardiac isolated mitochondria. Under review at BBA Bioenergetics, 2020. *Equal contribution as first author
99. Sun J, An J, Yang M, Heisner J, Mishra J, Stowe DF, Kwok WM, and Camara AKS. Hypothermia preserves complex I and cardiac function following ischemia by enhancing hexokinase II binding to mitochondria and limiting cytochrome c release independent of Bax. Submitted to PlosOne, 2020.
100. Yang M, Sun J, Stowe DF, Tajkhorshid E, Kwok WM, Camara AKS. Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-induced Cell Apoptosis Through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress. Submitted to Cellular Physiol. and Biochem, 2020.
101. Mehrvar S, Mostaghimi S, Camara AKS, F Foomani F, Narayanan J, Fish B, Medhora M,#, and Ranji#,* M. 3D Vascular Metabolic Imaging using Inverted Auto-fluorescence. Submitted to Submitted to Nature Biomedical Engineering, 2020.
102. Haloi N, Wen P-C, Cheng Q, Yang M, Natarajan G, Camara AKS, Kwok WM* and Emad Tajkhorshid*. Structural Basis of Complex Formation between Mitochondrial VDAC1 and Hexokinase-II. Submission PNAS, 2020.
103. Xu Y, Yang M, Li K, Sun J, Stowe DF, Kwok WM, and Camara AKS. Dissociation of hexokinase binding to VDAC increases state 3 respiration and reduces membrane potential repolarization time in mitochondria isolated from brain and heart (submitted to J Bioenergetics and Biomembranes, 2020).
104.  
105. BOOK CHAPTERS/REVIEWS/EDITORIALS
106. * Indicates peer reviewed
107. *1. Chen Q, Camara AKS, Stowe DF, Hoppel CL, and Lesnefsky EJ. Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion [review article]. Am J Physiol Cell Physiol 292: C137-C147, 2007 (PMID: 16971498). This article has been cited over 266 times.
108. Stowe DF, Camara AKS, Heisner JS, Aldakkak M, and Harder, DR. 20 h Preservation of guinea pig isolated hearts perfused at low flow with air -saturated Lifor Solution at 26°C, pp 445-450 [invited book chapter] in Recent Advances in Cardiovascular Disease - Proceedings of the 13th World Congress on Heart Disease; pp. 464, 2008. Edited by Kimchi A. Medimond International Proc, Bologna.
109. *3. Stowe DF and Camara AKS. Mitochondrial reactive oxygen species production in excitable cells: modulation of mitochondrial and cell function [invited comprehensive review]. Antioxid Redox Signaling 11:1373-1396, 2009 (PMID: 19187004). This article 395 citations to date.
110. *4. Camara AKS, Lesnefsky EJ, and Stowe DF. Potential therapeutic benefits of strategies directed to mitochondria [invited comprehensive review]. Antioxid Redox Signaling 13: 279-347, 2010 (PMID: 20001744).
111. Note: The manuscript was reviewed by seven internationally recognized mitochondrial experts (including Enrique Cadenas, U of Southern California, Andreas Daiber, Johannes Gutenberg University Mainz, Sabzali Javadov, University of Puerto Rico); it was recognized by the reviewers, as "an exceptional piece of work". The article contains approximately 70 published pages of a broad array of mitochondrial function and related diseases, including neoplastic, cardiovascular, skeletal muscle, and neurodegenerative diseases. The article has consistently enjoyed the spotlight of being in the top 20 lists (Domain of related articles 20001744) of publications related to mitochondrial biology. It has over 150 citations to date.
112. *5. Camara AKS, Aldakkak M, and Stowe DF. Mitochondria as potential therapeutic targets in mitochondria-related diseases [invited book chapter] in Mitochondria: Structure, Functions and Dysfunctions, NOVA Science Publisher (Cell Biology Research Progress, Nova Science Publishers, Inc. 400 Oser Ave Hauppauge, NY 11788-3619, USA pp 471-552, 2011. Edited by Dr. Oliver L. Svensson
113. *6. Camara AKS, Bienengraeber M, and Stowe DF. Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury [review article]. Frontiers in Physiol. 2(13): 1-34, 2011 (PMID: 21559063). The article has been cited over 105 times.
114. Note: This article was published in July 2011, and according to the journal, in one year the article received approximately 4000 total views, "...making it among the highest-performing articles in Frontiers." An e-mail sent to me reads, "As there is so much interest in your work and your field, Frontiers would like to invite to you to serve as Host Editor of a Frontiers Research Topic..." The article has also been recognized since its publication in the top 20 articles of interest (Domain of related articles 20001744) published on similar mitochondrial related topics.
115. *7. Camara AKS, Aldakkak M, Bienengraeber M, and Stowe DF. Cardioprotection by pre- and post-conditioning: implications for the role of mitochondria [invited review]. Acta Anesthesiologica Croatica, 8: 7-18, 2011. Cited 3 times
116. *8. Camara AKS, and Stowe DF. ROS and cardiac ischemia and reperfusion injury [invited book chapter], in Systems Biology of Free Radicals and Antioxidants, Springer-Verlag Publisher Berlin Heidelberg (Germany); Edited Dr. Ismail Laher, University of British Colombia, Canada Chapter 39 pp 889-949, 2014.
117. Note: Contributors include renowned authors in the field of mitochondrial biology. These include Andreas Daiber (Germany), Sergey Dikalov, Vanderbilt University, (USA), Takeshi Adachi (Japan), Miguel Aon, Johns Hopkins University, (USA) and David Harder, Medical College of Wisconsin, (USA).
118. *9. Aldakkak M, Stowe DF, and Camara AKS. Safety and efficacy of ranolazine for the treatment of chronic angina pectoris [invited review article) Clinical Medicine Insights: Therapeutics, 5:1-14, 2013. (PMID: 24574825). Cited 10 times
119. *10. Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ and Camara AKS. Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol. 5:341. doi: 10.3389/fphys.2014.00341. eCollection 2014. (PMID: 25278902). Cited 35 times
120. *11. Aon MA and Camara AKS. Mitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research. Front Physiol. 6:94. doi: 10.3389/fphys.2015.00094. eCollection 2015. (PMID: 25859223) [Editorial commentary]
121. Note: Dr. Miguel Aon (Johns Hopkins) and I were the editors for a "Special Call" for papers titled: "Mitochondria: Hubs of cellular signaling, energetics and redox balance". The call for paper exceeded expectations in terms of the total number of articles targeted and the actual number submitted for consideration. At the end, a total of 20 articles were submitted and all were accepted, except two. The contributors included numerous prominent investigators in the field of mitochondrial biology. The success of this editorial endeavor has led to the publication of an E-Book that shows 20 chapters, including 2 editorial comments (see below, #14). Cited 10 times.
122. Camara AKS. Referee Report for: Inhibition of CD34+ cell migration by matrix metalloproteinase-2 during acute myocardial ischemia, counteracted by ischemic preconditioning. F1000Research 2016, 5:2739 (doi: 10.5256/f1000 research 11302.r18941) The direct URL for this report is: https://f1000research.com/articles/5-2739/v2#referee-response-18941
123. *13. Camara AKS, Zhou Y, Tajkhorshid E, and Kwok WM. Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target. Front Physiol. 30;8:460. doi: 10.3389/fphys.2017.00460, 2017. (PMID: 28713289). Cited 45 times
124. *14. Aon MA and Camara AKS. Mitochondria: Hubs of cellular signaling, energetics and redox balance (Edited by: MA Aon and AKS Camara). Front in Physiol. E-book, August 2017. ISSN 1664-8714 ISBN 978-2-88945-239-2 DOI 10.3389/978-2-88945-239-2. See link: https://www.frontiersin.org/books/Mitochondria_Hubs_of_Cellular_Signaling_Energetics_and_Redox_Balance/1282
125. *15. Camara AK, Stowe DF, O-Uchi, and Bazil JN. Genetic Modification of Cardiac Tissue. Front Cardiovasc Med. 6;6:93. doi: 10.3389/fcvm.2019.00093. eCollection, 2019). [Editorial commentary] Special Research Topic "Genetic Modification of Cardiac Tissue" (PMID: 31380395).
126. *16. Javadov S,* Kozlov AV,* and Camara AKS*. Mitochondria in Health and Diseases. Cells. 9;9(5). pii: E1177. doi: 10.3390/cells9051177, 2020 [Editorial Commentary] Special Topic: "Mitochondria in Health and Diseases" (PMID: 32397376) *Equal senior authorship
127. Note: Drs. Sabzali Javadov (Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA), Andrey V. Kozlov (Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria) and I were the guest editors for a "Special Call" for papers titled: "Mitochondria in Health and Diseases". The call for paper exceeded expectations in terms of the total number of articles targeted and the actual number submitted for consideration. At the end, a total of nearly 30 articles were submitted and 24 from a wide range of topics were accepted with the remaining rejected. The Editorial is a compendium of overviews of each article in designated categories of "Mitochondria in health" and "Mitochondria in Disease".
128. *17. Natarajan GK, Mishra J, Camara AKS, Kwok WM. LETM1 - One entity, diverse roles. Submitted to Front Physiol- Mitochondrial Research. Review Special Topic: "Mitochondrial Exchangers and Transporters in Cell Survival and Death", 2020
129. *18. Mehrvar S, Camara AKS, Ranji M. 3D optical cryo-imaging method: a novel approach to quantify renal mitochondrial bioenergetics dysfunction. An invitation to submit manuscript for book chapter on methodologies, 2020.
130. *19. Javadov S,* Kozlov AV,* and Camara AKS*. Mitochondria in Health and Diseases. E-book, under production, 2020 *Editors
 
Abstracts
1. Camara A, Daston G., and Copeland J. Effects of chronic exposure to lead on a terrestrial mollusk fast burster neuron. J Neurosci 194 6: 696, 1987.
2. Tang R, R Stockman, Camara A, Fujimoto JM, and Tseng LF. Brain sites sensitive to -endorphin and morphine for analgesia and spinal release of met-enkephalin in anesthetized rats. FASEB J 3: A422, 1989.
3. Camara AKS, and Osborn JL. Renal neurogenic mediation of arterial pressure responses to high sodium intake-CNS AII hypertension. FASEB J 7 (4): 3211, 1993.
4. Camara AKS, He X-R, Wang WH, and Osborn JL. Selective postnatal sensitization to CNS AII by high sodium intake. FASEB J 8 (5): 4907, 1994.
5. Camara AKS, and Osborn JL. Central AT1 receptors mediate chronic ICV AII-hypertension via interactions with CNS alpha-adrenergic mechanisms. FASEB J 1697,1995.
6. Camara AKS, Clifford PS, and Osborn JL. Blockade of ICV AII mediated hypertension by -adrenergic receptor antagonist is dependent on dietary sodium chloride intake. J Neurosci 21(2): 551.4, 1995.
7. Camara AKS, Turner LA, Kulier A., and Bosnjak Z. -adrenergic effects on myocardial conduction velocity in the presence of halothane at elevated potassium levels. FASEB J 10 (3) 378: A65, 1996.
8. Camara AKS, Rehmert GC, Kwok W-M, and Bosnjak ZJ. Effects of anesthetics on the L-Type calcium current. Biophys J 72 (2): A258, 1997.
9. Camara AKS, Kwok W-M, and Bosnjak ZJ. Differential effects of isoflurane on L- and T-type calcium current in isolated guinea pig myocytes. Biophys J 74(2): A106, 1998.
10. Camara AKS, Kwok W-M, and Bosnjak ZJ. Isoproterenol potentiates halothane depression of cardiac L-Type Ca channel currents in guinea pig Myocytes. Biophys J 78(1): 599, 2000.
11. Ohsawa M, Mizoguchi H, Ohsawa M, Narita M, Nagase H, Camara A, and Tseng LF. Increased release of [Met5]enkephalin in the rat spinal cord by intracerebroventricularly-administered endorphin-2. J Neurosci 26(1): 238.9; 635, 2000.
12. Camara AKS, An JZ, Heisner, JS, Novalija E, Varadarajan SG, Chen Q, and Stowe DF. Na+/H+ exchange inhibitor EMD 96785 reduces diastolic Ca2+ and improves myocardial function after 4 Hours cold storage. Biophys J 80(1): 41a, 2001.
13. Chen Q, Camara AK, An JZ, Novalija E, Heisner JS, Varadarajan SG, and Stowe DF. Cytosolic Ca2+ loading is reduced by ischemic pre-conditioning after four hours of hypothermic ischemia. Biophys J 80(1): 608a, 2001.
14. Novalija E, Heisner JS, Camara A, Varadarajan SG, An JZ, Chen Q, and Stowe DF. Ischemic pre-conditioning (IPC) reduces peroxynitrite (OONO-) Release and improves function on reperfusion after global ischemia in isolated hearts. Biophys J 80(1): 581a, 2001.
15. Stowe DF, Goggins CP, Bartley BA, Rhodes SS, Camara, AK, An JZ, Heisner JS, Chen Q, Novalija E, and Ropella KM. How cardiac drugs alter contractility-myoplasmic calcium loops in intact beating hearts. Biophys J 80(1): 350a, 2001.
16. Camara AKS, Chen Q, An JZ, Varadarajan SG, Novalija E, Rhodes SS and Stowe DF. Effects of low calcium and high magnesium cardioplegia on phasic [Ca2+] and function after global ischemia in isolated hearts. FASEB J 15 (5): A768, 2001.
17. An JZ, Camara A, Chen Q, Varadarajan SG, Novalija E, and Stowe DF. Na+/H+ exchange inhibition reduces cytosolic Ca2+ loading and improves contractility on reperfusion after ischemia in intact hearts. FASEB J 15 (4): A463, 2001.
18. Chen Q, Camara AKS, An JZ, Varadarajan SG, Novalija E, and Stowe DF. KATP channel blockade by 5-hydroxy decanoate before brief ischemia does not block improved function or reduced cytosolic Ca2+ loading after four hours of 17C storage. FASEB J 15 (4): A463, 2001.
19. Novalija E, Varadarajan SG, Heisner JS, Chen Q, Camara AKS, An JZ, and Stowe, DF. Sevoflurane preconditioning (SPC) and peroxynitrite (ONOO-) release is not altered by blocking nitric oxide before SPC and global ischemia in isolated hearts. FASEB J 15 (3): A1133, 2001.
20. Novalija E, Camara AKS, Varadarajan SG, Hogg N, and Stowe, DF. Ischemic or anesthetic preconditioning reduces free radical formation and improves recovery on reperfusion after global ischemia in isolated hearts. Presented at the 6th annual Midwest Physiological Society meeting, 2001.
21. Ohsawa M, Brailoiu GC, Dun NJ, Paul K, Camara AKS, and Tseng LF. Modulation of nociceptive transmission by pituitary adenylate cyclase activating polypeptide (PACAP) in the spinal cord. J Neurosci 2001.
22. Camara AK, Chen Q, Novalija E, Riess ML, Jiang MT, Varadarajan SG, An JZ, and Stowe DF. Phasic [Ca2+] to pressure indices are altered differently by negative inotropic drugs before and after global ischemia in isolated hearts. Biophys J 82(1) Part 2of 2: 653a, 2002.
23. Chen Q, Camara AK, An JZ, Rhodes S, Riess ML, Novalija E, Varadarajan SG, and Stowe DF. How positive inotropic drugs alter cyclic [Ca2+] to LVP loops before and after ischemia in isolated hearts. Biophys J 82(1) Part 2of 2: 654a, 2002.
24. Riess ML, Chen Q, Camara AK, Novalija E, Rhodes SS, and Stowe DF. Dose-dependent anesthetic preconditioning by sevoflurane in isolated guinea pig hearts. Biophys J 82(1) Part 2of 2: 610a, 2002.
25. Stowe DF, Camara AK, Rhodes SS, An JZ, Riess ML, Chen Q, and Novalija E. Changes in area and flux indices of cyclic [Ca2+] to LVP by digoxin and dopamine before and after ischemia in intact hearts. Biophys J 82(1) Part 2of 2: 653a, 2002.
26. Rhodes SS, Stowe DF, Camara AK, Chen Q, Riess ML, and Ropella K. Quantifying cardiotonic drug efficacy on cytosolic [Ca2+] expenditure for contraction pre- and post-ischemia in intact hearts. Biophys J 82(1) Part 2 of 2: 66a, 2002.
27. Camara AKS, Chen Q, Riess ML, Novalija E, An JZ, and Stowe DF. Effects of negative inotropic drugs on efficiency of cardiac work per [Ca2+]i cost after ischemia reperfusion. FASEB J 16(5): A857, 2002.
28. Chen Q, Camara AKS, An JZ, Novalija E, Riess ML, Rhodes SS, and Stowe DF. Effects of positive inotropic drugs on efficiency of cardiac work per [Ca2+]i cost after ischemia reperfusion. FASEB J 16(5): A857, 2002.
29. Riess ML, Camara AKS, Chen Q, An JZ, Novalija E, Jiang MT, Stowe DF. Comparison of two methods to determine infarct size after global ischemia in isolated guinea pig hearts. FASEB J 16(5): A492, 2002.
30. Novalija E, Camara AKS, Jiang MT, Riess ML, Chen Q, Heisner JS, and Stowe DF. Anesthetic induced decreases in free radical formation and cell death after ischemia in isolated hearts: reversed by free radical scavengers. FASEB J 16(5): A855, 2002.
31. Riess ML, Varadarajan SG, Chen Q, Camara AKS, Novalija E, Rhodes SS, and Stowe DF. Anesthetic preconditioning decreases mitochondrial [Ca2+] overload during global ischemia in isolated guinea pig hearts. FASEB J 16(5): A488, 2002.
32. Hung K, Wu H, Mizoguchi H, Leitermann R, Camara A, and Tseng LF. Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endorphin-1 and endorphin-2 given intracerebroventricularly in the mouse. J Neurosci 2002.
33. Camara AKS, Kevin LG, Riess ML, Rhodes SS, Novalija E, and Stowe DF. Ischemic preconditioning reduces reactive oxygen species generation during cold ischemia and release after cold ischemia. Biophys J 84: A487, 2003.
34. Rhodes SS, Audi S, Stowe DF, Camara, AK, Kevin LG, and Ropella K. Modeling cross-bridge kinetics at 17°C vs. 37°C from cyclic Ca2+ and LVP in intact hearts. Biophys J 84: 2111A, 2003.
35. Riess ML, McCormick JC, Camara AKS, Rhodes SS, Kevin LG, and Stowe DF. Anesthetic preconditioning alters mitochondrial flavor protein redox state during global ischemia and reperfusion in isolated hearts. Biophys J 84: A2215, 2003.
36. Camara AKS, Kevin LG, Novalija E, Riess ML, and Stowe DF. Cold perfusion causes ROS formation and ischemia reperfusion reduces ROS formation in isolated hearts. FASEB J 17(5): A1265, 2003.
37. Novalija E, Camara AKS, Riess ML, and Stowe DF. Chelrythrine inhibits sevoflurane-induced protection after ischemia in isolated hearts. FASEB J 17(4): A107, 2003.
38. Camara AKS, Riess ML, Novalija, E, Rhodes SS, and Stowe DF. ROS generated during cold perfusion compromises protection against subsequent ischemia reperfusion injury. Biophys J, 86(1): 609a, 2004.
39. Riess ML, Camara AKS, Eells JT, Henry MM, Jiang MT, and Stowe DF. Attenuated mitochondrial respiration by sevoflurane in cardiac mitochondria is not mediated by KATP channel activation. Biophys J 86(1): 337a, 2004.
40. Riess ML, Eells JT, Camara AKS, Henry MM, and Stowe DF. Differential effects of diazoxide and pinacidil on attenuated ATP synthesis in isolated cardiac mitochondria. Biophys J 86(1): 460a, 2004.
41. Novalija E, Kevin LG, Camara AKS, Henry MM., Eells JT, and Stowe DF. Anesthetic preconditioning preserves mitochondrial membrane potential. Biophys J 86(1): 461a, 2004.
42. Jiang MT, Kevin, LG, Camara AKS, Riess, ML., and Stowe, DF. Myocardial protection by NS1619 is mediated by reactive oxygen species in guinea pig hearts. Biophys J 86(1): 465a, 2004.
43. Camara AKS, Riess ML, Heisner JS, An JZ, Aldakkak M, Novalija E, and Stowe DF. Superoxide scavengers improve cardiac function after 2 hr cold ischemia at 27°C in guinea pig isolated hearts: Role of NADH and FAD. FASEB J 18(II): A1031. 2004.
44. Stowe DF, Camara AKS, Kevin LG, Heisner JS, Rhodes SS, Riess M., and Jiang MT. Cardiac preconditioning by large conductance KCa channels leads to improved mitochondrial redox state. FASEB J 18(II): A1004. 2004
45. Jiang MT, Camara AKS, Kevin LG, Riess, ML, Novalija E, and Stowe DF. Putative role of small conductance KCa channel opening in cardiac pharmacologic preconditioning FASEB J 18(II): A1003, 2004.
46. Riess ML, Camara AKS, Jiang, MT, Kevin LG, Rhodes SS, and Stowe DF. KATP channel-independent changes in mitochondrial redox state by diazoxide and pinacidil in intact guinea pig hearts. FASEB J 18(I): 198.13, A263, 2004.
47. Rhodes SS, Ropella K, Camara AKS, Riess ML, Nicolosi AC, Heisner JS, and Stowe, DF. Ischemic stunning increases cytosolic Ca2+ but does not Alter stretch-induced changes in the contractile -[Ca2+] relationship in guinea pig intact hearts. FASEB J 18(II): A1090, 2004.
48. Katz PJ, Aldakkak M, Kevin LG, Camara AKS, Stowe DF, and Novalija E. Role of ion regulatory mechanisms in triggering phase of anesthetic preconditioning. FASEB J 18(I): A1090, 2004.
49. An JZ, Camara AKS, Rhodes SS, Riess ML, Bosnjak ZJ, and Stowe DF. Improved mitochondrial bioenergetics and myocardial function by ischemic preconditioning before hypothermic ischemia: role of KATP channel opening. FASEB J 18(I): A260, 2004.
50. Riess ML, Camara AKS, Jiang MT, Kevin LG, Rhodes SS, and Stowe, DF. Differential effects of KATP channel openers on mitochondrial respiration under different physiological conditions. Biophys J 88(1): 461a, 2005.
51. Camara AKS, Aldakkak M, Riess ML, Rhodes SS, Heisner JS, Heinen A, An JZ, and Stowe DF. Cold cardioplegia reduces reactive oxygen species formation and mitochondrial Ca2+ overload and preserves mitochondrial bioenergetics: role in cardioprotection. Biophys J 88(1): 162a, 2005.
52. Rhodes SS, Ropella K, Camara AKS, Riess ML, Heisner JS, and Stowe DF. Blockade of autonomic control in isolated hearts modulates heart rate variability after reperfusion injury. Biophys J 88(1): 176a, 2005.
53. Heinen A, Camara AKS, Riess ML, Aldakkak M, Jiang MT, and Stowe DF. Ca-Sensitive potassium channel activation by NS1619 increases state 2 respiration in isolated heart mitochondria. Biophys J 88(1): 440a, 2005.
54. Forder JP, Munzenmaier DH, Camara AKS, and Greene AS. ICV infusion of AT1 antagonist indicates angiogenic protection against permanent focal ischemia in the rat. FASEB J 19 (Part II): A1250, 2005.
55. Aldakkak M, Stowe DF, Heinen A, Heisner JS, Rhodes SS, Carlson Jr. R, and Camara AKS. Perfusion of ROS Scavengers before ischemia enhances protective effects of cardioplegia against cold ischemia and warm reperfusion in isolated hearts. FASEB J 19 (Part I): A705, 2005.
56. Heinen A., Camara AKS, Riess ML, Aldakkak M, Rhodes SS, and Stowe, DF. Activation of Ca2+ sensitive K+ channels by NS1619 reduces respiratory control index in isolated heart mitochondria. No effect of ROS scavengers. FASEB J 19 (Part I): A565, 2005.
57. Stowe DF, Aldakkak M, Heisner JS, Heinen A, Camara AKS, Varadarajan SG, Riess ML, Rhodes SS, and Jiang MT. Mitochondrial big Ca-sensitive K+ channel opening reduces changes in redox state and Ca2+ loading during and after ischemia in isolated guinea pig hearts. FASEB J 19 (Part I): A694, 2005.
58. Rhodes SS, Heisner JS, Camara AKS, Heinen A, Aldakkak M, Riess ML, and Stowe DF. Streptomycin improves contractile function after ischemic stunning but does not modulate stretch-induced changes in myocyte Ca2+-contraction coupling in isolated hearts. FASEB J 19 (Part I): A562, 2005.
59. Camara AKS, Aldakkak M, Heinen A, Riess ML, Rhodes SS, Carlson R, and Stowe DF. Na+/H+ exchanger inhibition increases mitochondrial respiration in an inverse temperature dependent manner. FASEB J 19 (Part I): A565, 2005.
60. Camara AKS, Aldakkak M, Heisner JS, Rhodes SS, Heinen A, Varadarajan SG, Riess ML, and Stowe, DF. Acidotic perfusion protects against ischemic injury by improving mitochondrial redox balance FASEB J 20 (4): A742, 2006.
61. Camara AKS, Stowe DF, Gruenloh SK, Heinen A, Aldakkak M and Medhora MM. Succinate -dependent respiratory capacity is reduced in human coronary artery endothelial cells after cold incubation and rewarming. FASEB J 20 (5): A1165, 2006.
62. Aldakkak M, Heisner JS, Stowe DF, Chen Q, Lesnefsky EJ, Heinen A, Rhodes SS, and Camara AKS. Amobarbital, high K+ and lidocaine protect hearts against ischemia reperfusion injury by differential changes in mitochondrial bioenergetics. FASEB J 20 (4): A319, 2006.
63. Rhodes SS, Camara AKS, Heinen A, Heisner JS, Aldakkak M, and Stowe DF. Improved return of left ventricular function and myoplasmic [Ca2+] after ischemia reperfusion injury in hearts from old vs. young guinea pigs. FASEB J 20 (4): A384, 2006.
64. Rhodes SS, Ropella KM, Camara AKS, Heinen A, Aldakkak M, Heisner JS, and Stowe DF. Transfer entropy is better indicator of changes in AV coupling than standard measures of AV conduction. FASEB J 20 (4): A321, 2006.
65. Heinen A, Aldakkak M, Camara AKS, Rhodes SS, Riess ML, Varadarajan SG, and Stowe DF. Activation of mitochondrial Ca2+ Sensitive potassium channels enhances mitochondrial reactive oxygen species production. FASEB J 20 (4): A315, 2006.
66. Varadarajan SG, Johnson CS, Camara AKS, Heisner JS, Heinen A, and Stowe DF. Mitochondrial Ca2+-dependent big K+ channels in post-conditioning of guinea pig isolated hearts. FASEB J 20 (5): A1154, 2006.
67. Vernon MR, Camara AKS, Aldakkak M, Heinen A, and Stowe DF. Modulatory effects of endogenous nitric oxide on the bioenergetics of BKCa channels in guinea pig isolated cardiac mitochondria. FASEB J 20 (5): A893, 2006.
68. Huang M, Stowe DF, Camara AKS, and Beard DA. Kinetic analysis of isolated mitochondrial functions. FASEB J 20 (5): A1300, 2006.
69. Basile DP, Camara A, and Van Why, S. Protection from injury in brown Norway rats may be due to mitochondrial integrity following ischemia/reperfusion. FASEB J 20 (4): A336, 2006.
70. Camara AKS, Stowe DF, Dunn LK, Gruenloh SK, Aldakkak M and Medhora MM. Hypoxia and reoxygenation of human coronary artery endothelial cells retards oxidative stress without impairing respiratory capacity Biophys J, 2007.
71. Aldakkak M, Camara AKS, Beard DA, Dash R, Huang M, and Stowe DF. NS1619 increases potassium influx in the isolated intact mitochondrion in a dose dependent manner Biophys J, 2007.
72. Huang M, Dash R, Camara AKS, Stowe DF, Aldakkak M, and Beard DA. Mitochondrial ROS metabolism-experiment and modeling Biophys J, 2007.
73. Beard DA, Camara AKS, Dash R, Feng Q, Rhodes SS, Stowe DF, Vinnakota KC, Wu F, and Yang F. Integrated modeling of mitochondrial bioenergetics and calcium and ROS handling Biophys J, 2007.
74. Huang M, Camara AKS, Stowe DF, and Beard DA. Quantitative analysis of mitochondrial membrane potential measurements with JC-1 FASEB J 21 (6): A1351, 2007.
75. Camara AKS, Dunn LK, Gruenloh SK, Aldakkak M Stowe DF, Jacobs ER, and Medhora MM. 24 h hypoxia and 4 h reoxygenation retards ADP-dependent respiration in HCAEC without altering caspase-3 activity or mitochondrial respiratory capacity. FASEB J 21 (6): A922, 2007.
76. Spence M, Aldakkak M, Heisner JS, Stowe DF, Rhodes SS, and Camara AKS. Na+/H+ exchange inhibition protects against ischemic injury by preserving mitochondrial redox state, and by reducing mitochondrial Ca2+ overload and ROS production. FASEB J 21 (6): A1221, 2007.
77. Aldakkak M, Stowe DF, Rhodes SS, Beard DA, Dash R, Huang M, and Camara AKS. Hypothermia enhances reactive oxygen species generation from complex III with succinate and rotenone but not with pyruvate. FASEB J 21 (6): A820, 2007.
78. An JZ, Camara AKS, Bienengraeber M, and Bosnjak Z. Nitric oxide is not involved in the attenuation of complex I-linked mitochondrial state 3 respiration by isoflurane. FASEB J 21 (6): A863, 2007.
79. Stowe DF, Heisner JS, Camara AKS, Aldakkak M, and Harder DR. Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at room temperature. FASEB J 21 (6): A1224, 2007.
80. Johnson C, Camara AKS, Aldakkak M, Heisner JS, Varadarajan SG, Stowe DF and Rhodes SS. Improved mitochondrial Ca2+ handling and functional recovery after ischemia reperfusion injury in hearts from old vs. young guinea pigs FASEB J 21 (6): A1223, 2007.
81. Dash RK, Aldakkak M, Huang M, Rhodes S, Camara AKS, Stowe DF, and Beard DA. Integrated roles of Ca2+ uniporter, Na+-Ca2+ exchanger and Na+-H+ exchanger in regulating Ca2+, Na+ and pH flux in cardiac mitochondria using in vitro spectrofluorometry. FASEB J 21 (6): A1352, 2007.
82. Varadarajan SG, Camara AKS, Rhodes SS, Aldakkak M, Heisner JS, and Stowe DF. Cardiac mitochondrial Ca2+ -dependent big K+ channels are open during reperfusion. FASEB J 21 (6): A1224, 2007.
83. Dash RK, Rhodes SS, Sharma S, Aldakkak M, Camara AKS, Stowe DF, and Beard DA. Integrated role of mitochondrial cation transport system in the regulation of mitochondrial Ca2+. Bio Med Eng Soc P3.4, 2007.
84. Camara AKS, Stowe DF, Dunn LK, Gruenloh SK, Aldakkak M, and Medhora MM. 24 h hypoxia of human coronary artery endothelial cells (HCAEC) does not alter cell viability but impairs oxidative phosphorylation. Biophys J 1565-Pos, 2008.
85. Aldakkak M, Camara AKS, Patel R, Haumann J, Rhodes SS, and Stowe DF. Inactivation of cardiac mitochondrial K/H exchange by quinine exposes matrix acidification and K+ influx by putative Ca2+-dependent K channels. Biophys J 436-Pos, 2008.
86. Dash RK, Stowe DF, Camara AKS, Aldakkak M, Haumann J, Rhodes SS, and Beard DA. Computational modeling of mitochondrial Ca2+ ion flux via the Ca uniporter: Modulation by isoflurane Biophys J, 2008.
87. Haumann J, Herrera M, Vega JL, Aldakkak M, Camara AKS, Bienengraeber M, Dash RK, and Stowe DF. Isoflurane enhances buffer Ca-induced mitochondrial Ca2+ ion flux: Role of mitochondrial Ca2+ ion uniporter? Biophys J 1254-Pos, 2008.
88. Aldakkak M, Stowe DF, Heisner JS, Haumann J, and Camara AKS. Blocking mitochondrial Ca2+ uniporter activity during activated Na+/H+ exchange reduces mCa2+ loading but does little to better protect function on reperfusion. FASEB J 730.24 pos, 2008.
89. Dash RK, Haumann J, Patel R, Aldakkak M, Rhodes SS, and Camara AKS, Stowe DF, Vinnakota KC, Beard DA. Regulation of mitochondrial free Ca2+ by metabolite and pH dependent Ca2+ buffering in the matrix: analysis by a computational model of mitochondrial Ca2+ handling. FASEB J 756.7 pos, 2008.
90. Haumann J, Patel R, Aldakkak M, Rhodes SS, Vinnakota KC, Dash RK, Camara AKS, Beard DA, and Stowe DF. ADP and CCCP-induced increases in mitochondrial free Ca2+: greater contribution of matrix Ca2+ buffering by ATP/ADP. FASEB J 756.6 pos, 2008.
91. Mio Y, Camara AKS, Bosnjak ZJ, and Bienengraeber MW: Isoflurane produces reactive oxygen species, trigger anesthetic-induced preconditioning, by inhibition of complex I in rat cardiac mitochondria Biophys J pos 113, 2008).
92. Rhodes SS, Dune BE, Riess ML, Camara AKS, and Stowe DF. Automated detection of infarct size in isolated hearts using novel image processing protocols (BMES abstracts available online) Ann Biomed Eng, 2008.
93. Haumann J, Stowe DF, Aldakkak M, Patel R, Vernon M, Dash RK, Beard DA, and Camara AKS. ADP/ATP antiport and ADP phosphorylation increases mitochondrial free Ca2+. Biophys J 1251 pos, 2009.
94. Haumann J, Hartman C, Dash RK, Aldakkak M, Camara AKS, and Stowe DF. Characterizing the calcium uniporter: effect of partial depolarization on calcium flux Biophys J 1250 pos, 2009.
95. Aldakkak M, Stowe DF, Haumann J, Dash RK, and Camara AKS: Substrate dependent mitochondrial pH changes during oxidative phosphorylation. Biophys J 1233 pos, 2009.
96. Aldakkak M, Trichler T, Camara AKS, Haumann J, and Stowe DF. Quinine causes mitochondrial uncoupling independent of K+/H+ exchange inhibition. Biophys J 1233 pos, 2009.
97. Dash RK, Thompson MD, Vinnakota KC, Haumann J, Aldakkak M, Camara AKS, Stowe DF, and Beard DA. Modeling regulation of mitochondrial free Ca2+ by ATP/ADP-dependent Ca2+ buffering. Biophys J 41 plat, 2009.
98. Dash RK, Thompson MD, Vinnakota KC, Haumann J, Aldakkak M, Camara AKS, and Stowe DF, Beard DA. Modeling regulation of mitochondrial free Ca2+ by metabolite dependent Ca2+ buffering. FASEB J 994.2 pos, 2009.
99. Haumann J, Hartman C, Dash RK, Aldakkak M, Dash RK, Camara AKS, and Stowe DF. Uncoupler induced graded mitochondrial depolarization and attenuated matrix calcium uptake is enhanced by complex V inhibition indicative of blocked ATP hydrolysis. FASEB J 994.2 pos, 2009.
100. Haumann J, Aldakkak M, Heisner JS, Stowe DF, and Camara AKS. Hypothermia impedes calcium induced mitochondrial permeability transition pore opening in mitochondria harvested after cold ischemia of isolated hearts. FASEB J 508.4 pos, 2009.
101. Aldakkak M, Heisner J, Haumann J, Stowe DF, and Camara AKS. Mild hypothermia on reperfusion after warm ischemia improves guinea pig isolated heart function. FASEB J 793.16 pos, 2009.
102. Aldakkak M, Heisner J, Camara AKS, Haumann J, and Stowe DF. Ranolazine a late sodium current inhibitor reduces ischemia induced superoxide emission and improves functional recovery in guinea pig isolated hearts. FASEB J 793.17 pos, 2009.
103. Henry, M, Stowe DF, Heisner JS, Rao R, Dhala A, Camara AKS, Whelan HT. Photobiomodulation reduces perilesional myocardial injury during radiofrequency ablation in guinea pig hearts. FASEB J 576.8pos, 2009.
104. Nadvar N, Camara AKS, Heisner J, Stowe DF, Rhodes SS. Power spectral analysis of heart rate variability in isolated, denervated guinea pig hearts reveal changes in symapthovagal balance by blockade of circulating neurotransmitters. Midwest Biomedical Engineering Conference 2009.
105. Aldakkak M, Stowe DF, Boelens A, Haumann J, Dash RK, Riess ML, and Camara AKS. Ca2+ enhances ROS generation from inhibited complex I but not from inhibited complex II with NADH-linked substrate Biophys J 3829 pos, 2010.
106. Boelens A, Dash RK, Haumann J, Camara AKS, Aldakkak M, Gadicherla AK, and Stowe DF. Buffer Mg2+ limits mitochondrial Ca2+ uptake but not matrix Ca2+ buffering in response to ADP. Biophys J 3827.pos, 2010.
107. Haumann J, Heisner JS, Boelens AD, Aldakkak M, Stowe DF, and Camara AKS. Hypothermic cardioprotection attenuates mitochondrial permeability transition pore opening and calcium loading in isolated cardiac mitochondria. Biophys J pos 3826, 2010.
108. Yang M, Gadicherla AK, Stowe DF, Bienengraeber M, Wakim B, and Camara AKS. Ranolazine reduces mitochondrial tyrosine nitration during cardiac ischemia and reperfusion injury. Biophys J pos 1956, 2010.
109. Gadicherla AK, Yang M, Camara AKS, Aldakkak M, Boelens A, Wakim B, and Stowe DF. Ranolazine preserves the integrity of mitochondrial supercomplexes. Biophys J pos 299, 2010.
110. Gadicherla AK, Antholine WE, Camara AKS, Heisner JS, Aldakkak M, Boelens A, and Stowe DF. Free radical generation and electron flux in mitochondrial Fe-S centers during cardiac injury; changes with mitochondrial protective drug ranolazine. Biophys J pos 3826, 2010.
111. Gadicherla AK, Antholine WE, Heisner JS, Camara AKS, Aldakkak M, Boelens A, Yang M, and Stowe DF. Protection of NADH-linked Fe-S clusters in cardiac mitochondria by ranolazine. FASEB J pos 601.9, 2010.
112. Boelens AD, Stowe DF, Aldakkak M, Gadicherla AK, Dash RK, Haumann J, and Camara AKS. Reduced mitochondrial volume contributes but cannot explain the increase in matrix free calcium after addition of ADP. FASEB J pos 1048.9, 2010.
113. Agarwal B, Boelens AD, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane enhances mitochondrial free Ca2+ in response Ca2+ but not ADP; possible role of isoflurane in activating mitochondrial Ca2+ uniporter. FASEB J pos 1048.7, 2010.
114. Dash RK, Agarwal B, Boelens AD, Haumann J, Camara AKS, Stowe DF, and Beard DA. Modeling regulation of matrix free Ca2+, by extra-matrix Mg2+ and ADP phosphorylation. FASEB J pos 1048.4, 2010.
115. Aldakkak M, Camara AKS, Heisner JS, Gadicherla AK, Boelens A, Yang M, Dash RK, and Stowe DF. Ranolazine delays Ca2+-induced mitochondrial permeability transition pore opening and membrane potential depolarization in guinea pig heart mitochondria. FASEB J pos 591.3, 2010.
116. Yang M, Camara AKS, Aldakkak M, Wakim B, Gadicherla AK, Boelens A, Heisner JS, and Stowe DF. Enhanced nitration of several mitochondrial proteins during cardiac ischemia and reperfusion injury. FASEB J, 2010.
117. Boelens AD, Camara AKS, Dash RK, Pradhan RK Thompson O, and Stowe DF. Increases in extra-matrix Mg2+ inhibit Ca2+ uptake via the Ca2+ uniporter but do not acutely alter state 3 respiration. Biophys J, 2011.
118. Yang M, Stowe DF, Gadicherla AK, Heisner JS, Boelens A, Wakim B, and Camara AKS. Reduced tyrosine nitration of VDAC and decreased apoptosis by mitochondria-directed therapy after cardiac ischemia reperfusion in isolated hearts. Biophys J, 2011.
119. Agarwal B, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane increases mitochondrial free Ca2+ by enhancing transport via the Ca2+ uniporter independent of m. Biophys J, 2011.
120. Gadicherla AK, Nielsen D, Camara AKS, Yang M, Bienengraeber, and Stowe DF. Differential decreases in respiratory complex I and II expression and activity after cardiac ischemia and reperfusion and modulation by mitochondria targeted therapy. Biophys J, 2011.
121. Aldakkak M, Stowe DF, Dash RK, Riess ML, and Camara AKS. Excess Ca2+ enhances ROS generation from inhibited complex III with FADH2-Linked substrate but not NADH-linked substrate. FASEB J, 188 pos 639.6, 2011.
122. Pradhan RK, Boelens AD, Bazil J, Camara AKS, Stowe DF, Beard DA and Dash RK. Effect of extra-matrix Mg2+ on matrix free Ca2+: analysis by integrated model of mitochondrial Ca2+ handling poster FASEB J, 2011.
123. Yang M, Camara AKS, Wakim BT, Gadicherla AK, Aldakkak M, Boelens AD, Heisner JS, and Stowe DF. Peroxynitrite produced during cardiac ischemia-reperfusion injury induces nitration of mitochondrial voltage-dependent anion channel poster. FASEB J, 2011.
124. Bazil J, Pradhan RK, Boelens AD, Camara AKS, Stowe DF, Beard DA and Dash RK. An integrated model that accurately characterizes Ca2+-uptake, efflux, and storage mechanisms in isolated mitochondria. FASEB J, 2011.
125. Du J, Guan T, Yang Q, Xu H, Welak S, Prichard KA Jr., Camara AKS, and Yang S. ECHDC2, a novel mitochondria protein is abundantly expressed in SS rat hearts: Implications for ischemia/reperfusion injury. FASEB J pos 639.16, 2011.
126. Gadicherla AK, Camara AKS, Yang M, and Stowe DF. Cardiolipin degradation during ischemia reperfusion: partial restoration by ranolazine. FASEB J 188 pos 639.17, 2011.
127. Sidham S, Nabi R, Camara AKS, Riess ML. Development of automated infarct size measurement in TC-stained rat isolated hearts after global ischemia/reperfusion. FASEB J pos 394 1130.2, 2011.
128. Blomeyer CA, Stowe DF, Pradhan RK, Bazil JN, Dash RK, Camara AKS. Sodium-induced calcium flux via mitochondrial NCE is dissimilar when derived from matrix and extra-matrix calcium concentrations. Biophys J, 2012.
129. Bazil JN, Pradhan RK, Blomeyer CA, Camara AKS, Stowe DF, Dash RK. Modeling the paradoxical increase in mitochondrial calcium buffering power as matrix calcium increases. Biophys J, 2012.
130. Yang M, Stowe DF, Heisner JS, Aldakkak M, and Camara AKS. Resveratrol or 32°C hypothermia applied after cardiac ischemia reduces mitochondrial translocation of p66shc. Experimental Biology, 2012.
131. Yang M, Camara AKS, Kwok W-M, Zhou Y, Gadicherla AK, and Stowe DF. Tyrosine nitration of voltage dependent anion channels by peroxynitrite alters protein structure and function in vitro. Experimental Biology, 2012.
132. Aldakkak M, Stowe DF, Dash RK, and Camara AKS. Mitochondrial handling of excess Ca2+ is substrate-dependent with implications on ROS generation. Experimental Biology, 2012.
133. Gadicherla AK, Camara AKS, Kwok W-M, Zhou Y, and Stowe DF. Identification, localization and electrophysiologic characterization of small Ca2+-sensitive K+ channels in cardiac mitochondria. Experimental Biology, 2012.
134. Agarwal B, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane increases mitochondrial free Ca2+ by attenuating the Na+/Ca2+ exchanger activity. Experimental Biology, 2012.
135. Cheng Q, Elorbany R, Stowe DF, Camara AKS, Weihrauch D, and Riess ML. Acute administration of PPAR agonist rosiglitazone in isolated hearts differentially aggravates cardiac ischemia reperfusion injury in a consomic rat model. Experimental Biology, 2013.
136. Lindsay DP, Camara AKS, Stowe DF, and Aldakkak M. Differential effects of low pH on Ca2+-induced ROS emission from mitochondrial complexes I and III. Experimental Biology, 2013.
137. Yang M, Stowe DF, Heisner JS, and Camara AKS. Attenuating complex I activity decreases p66shc phosphorylation and translocation to mitochondria during cardiac ischemia reperfusion injury. Experimental Biology, 2013.
138. Aldakkak M, Stowe DF and Camara AKS. Ca2+-induced mitochondrial permeability transition pore opening is substrate-dependent. Experimental Biology, 2013.
139. Agarwal B, Dash RK, Bosnjak ZJ, Stowe DF and Camara AKS. Substrate-dependent action of isoflurane on electron transport chain complexes. Experimental Biology, 2013.
140. Yang M, Camara AKS, Bienengraeber M, Kwok W-M, and Stowe DF. Putative small conductance Ca2+-sensitive K+ channels isoforms and splice variants in mitochondria of guinea pig cardiac ventricular myocytes. Experimental Biology, 2013.
141. Cheng Q, Yang M, Heisner JS, Bienengraeber M, Kwok W-M, Camara AKS and Stowe DF. Decreased nitration of mitochondrial complex I by ROS/RNS scavenging during cardiac ischemia reperfusion injury. Experimental Biology, 2013.
142. Tewari S, Zhou Y, Camara AKS, Dash RK, Kwok W-M. Post-translationally modified cardiac mitochondrial VDAC1 gating analyzed using continuous-time MCMC model. Experimental Biology, 2013.
143. Tewari S, Pradhan RK, Bazil JN, Camara AKS, Stowe DF, Beard DA and Dash RK. Characterization of different modes of Ca2+ uptake under physiological conditions in heart mitochondria. Experimental Biology, 2013.
144. Blomeyer CA, Bazil JN, Stowe DF, Dash RK, and Camara AKS. The potential for another calcium uptake mode in cardiac mitochondria. Oral presentation in a Platform series at the Biophysical Society meeting entitled "Calcium Signaling", 2014.
145. Aldakkak M, Stowe DF, and Camara AKS. Excess Ca2+ and succinate-induced mitochondrial H+ permeability. Experimental Biology, 2014.
146. Agarwal B, Dash RK, Bosnjak ZJ, Stowe DF, and Camara AKS. Isoflurane induces substrate-dependent early mitochondrial PTP opening. Experimental Biology, 2014.
147. Stowe DF, Yang M, Schwabe D, Heisner J, Camara AKS. Differential effects of small and big Ca2+-sensitive K+ channel agonists and antagonists during cardiac ischemia and reperfusion injury. Experimental Biology, 2014.
148. Yang M, Camara AKS, Bienengraeber M, Kwok WM, and Stowe DF. Overexpression of small conductance Ca2+-sensitive K+ channel (SKCa) isoform 3.1 in HL-1 myocyte mitochondria. Experimental Biology, 2014.
149. Yang M, Kwok WM, Bienengraeber M, Camara AKS, Heisner JS and Stowe DF. Preventing nitration of specific tyrosine sites in adenine nucleotide translocase differentially protects against cell oxidative stress injury. Experimental Biology, 2015.
150. Lubbe RJ, Lindsay DP, Aldakkak M, Camara AKS, and Stowe DF, and. Differential effects of buffer pH, CaCl2, and superoxide dismutase on Ca2+-induced H2O2 release from mitochondrial complexes I and III. Experimental Biology, 2015.
151. Salzman MM, Cheng Q, Weihrauch D, Camara AKS, Stowe DF and Riess ML. PPAR-independent side effects of thiazolidinediones on mitochondrial redox state in rat isolated hearts. Experimental Biology, 2015.
152. Boswell M, Camara AKS, Heisner JS, Blomeyer CA, and Stowe DF. Altering buffer Ca2+ and pH stimulates mitochondrial Ca2+/H+ exchanger. Experimental Biology, 2016.
153. Ranji M, Salehpour F, Motlagh MM, Sepehr R, Heisner JS, Dash RK, and Camara AKS. Optical cryoimaging reveals a heterogeneous distribution of mitochondrial redox state in ex vivo guinea pig hearts and its alteration during ischemia and reperfusion. Experimental Biology, 2016.
154. Williams AM, Olson J, Yan Y, Bai X, Camara AKS, Bosnjak ZJ. Effects of succinate on cardiomyocyte mitochondrial H2O2 production and cell death. Experimental Biology, 2016.
155. Camara AKS, Salehpour F, Motlagh MM, Sepehr R, Dash RK and Ranji M. Optical Cryo-imaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in the Ex-Vivo Guinea Pig Heart and its Alteration during Ischemia and Reperfusion. Experimental Biology, 2016.
156. Gerdes H, Camara AKS, Heisner JS, and Stowe DF. Peroxynitrite produced via nitric oxide synthesis in isolated cardiac mitochondria. Biophys J, 2016.
157. Ait-Aissa K, Heisner JS, Strande JL, Harmann L, Camara AK, Beyer AM. Telomerase deficiency predisposes to heart failure and ischemia/reperfusion injury. Experimental Biology, 2017 (symposium presentation).
158. Davani AJ, Navarro CD, Heisner JS, Pannala VR, Dash RK, Stowe DF, and Camara AKS. The Mitochondrial Adenine nucleotide pool contributes to the matrix Ca2+ buffering system. Experimental Biology, 2017.
159. Yang M, Camara AKS, Aldakkak M, Kwok WM and Stowe DF. Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel variant. Experimental Biology, 2017.
160. Yang M, Camara AKS, Kwok WM and Stowe DF. Stress-induced nitration of the voltage-dependent anion channel and its dissociation with hexokinase and adenine nucleotide translocase: implications in cardiac injury. Experimental Biology, 2017.
161. Manhas N, Garcia G, Camara AKS, and Dash RK. Modeling the Effects of Volatile anesthetics on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiomyocytes Biophysical Society, 2017.
162. Medhora M, Fish BL, Gao F, Narayanan J, Harmann L, Camara AKS, Ranji M, Jacobs ER, Strande J. Multiple organ injury after whole thorax irradiation induces cardiac remodeling with functional changes. Radiation and Research Society. October 2017.
163. Manhas N, Camara AKS, and Dash RK. Modeling mechanisms of cardiac L-type Ca2+ channel regulation: interactions of voltage, Ca2+ and isoflurane. Biophysical Society annual meeting, 2018.
164. Mishra J, Davani AJ, Stowe DF, Kwok WM, and Camara AKS. Cyclosporine A: A new insight into its potential role in mitochondrial calcium buffering. Biophysical Society annual meeting, 2018.
165. Glait L, Mishra J, Heisner JS, Stowe DF, Camara AKS, and Kwok WM. Matrix calcium efflux via the putative mitochondrial Calcium-Hydrogen Exchanger: Implications in mPTP opening. Biophysical Society annual meeting, 2018.
166. Yang M, Grzybowski M, Chen Q, Stowe DF, Geurts A, Wen P-O, Haloi N, Tajkhorshid E, Camara AKS, and Kwok WM. Phosphorylation of cardiac mitochondrial VDAC1 at S215 facilitates cell death. Biophysical Society annual meeting, 2018.
167. Goss MA, Heisner JS, Kwok WM, Camara AKS, Stowe DF. The "m" Conformation of adenine nucleotide translocase enhances cyclosporine A -induced delay of mitochondrial Ca2+ uptake after cardiac ischemia/reperfusion injury. Biophysical Society annual meeting, 2018.
168. Xu Y, Yang M, Li K, Stowe DF, Kwok WM, Camara AKS#. Dissociation of hexokinase II binding to VDAC increases state 3 respiration and reduces membrane potential repolarization time in mitochondria isolated from brain and heart. Experimental Biology, 2018 annual conference. #Poster presenter
169. Stowe DF, Yang M, Mishra J, Kim J, Heisner JM, Ali M, Zimmerman MA, Camara AKS, Hong JC. Sub-normothermic regulated hepatic reperfusion preserves mitochondrial function in swine liver procured after cardiac death. Experimental Biology, 2018 annual conference.
170. Kandel SM, Tomar N, Audi SH, Camara AKS, Cowley AW, Dash RK. Calcium regulation of mitochondrial respiration is substrate dependent and tissue specific. Experimental Biology 2018, annual conference.
171. Kim J, Shin WY, Zimmerman MA, Martin A, Yee J, Hagen C, McGraw J, Camara A, Stowe D, and Hong JC. Ex vivo sub-normothermic regulated hepatic reperfusion is superior to normothermic machine perfusion: a novel concept of liver resuscitation after cardiac death in large animal model. 13th World Congress of the International Hepato-Pancreato-Biliary Association Abstract: A-953-0030-01748, 2018.
172. Bevers K, Lambert D, Li K, Mishra J, Heisner JS, Stowe DF, Kwok WM, Camara AKS. Differences in mitochondrial Ca2+ handling during challenges of CaCl2 pulses in brain synaptic and non-synaptic mitochondria: implications for differential Ca2+ buffering. Experimental Biology Board & Program #:E522 660., 2019.
173. Lambert D, Bevers K, Heisner JS, Camara AKS, Kwok WM, Stowe DF. K+ influx triggers slow K+/H+ exchange detected by biphasic changes in matrix pH in Guinea pig cardiomyocyte mitochondria. Experimental Biology #:E528 660.7, 2019.
174. Mishra J, Davani A, Natarajan G, Stowe DF, Kwok WM, Camara AKS. Cyclosporine-A Enhances Mitochondrial Calcium Buffering to Delay mPTP Opening. Experimental Biology #:E530 660.9, 2019.
175. Stowe DF, Heisner JS, Camara AKS, Lambert D, Glait L, Bevers K, Mishra J, Kwok WM. Prevention of mitochondrial pH gradient dissipation: a novel role for cyclosporin A on inhibiting calcium-hydrogen exchange activity in cardiac isolated mitochondria. Experimental Biology #:E533 660.12, 2019.
176. Haloi N, Wen P-C, Camara AKSC, Kwok WM and Tajkhorshid E. Modeling the Insertion of Hexokinase in the Mitochondrial Outer Membrane and Its Complex Formation with VDAC. Biophysical Society 2019; Biophysical Journal 116(3):267a-268a
177. Haloi N, Wen P-C, Camara AKS, Kwok WM, and Tajkhorshid E. Membrane-anchored Hexokinase II binds to VDAC. Submitted to Biophysical Society 2020 conference, San Diego Ca.
178. Chen Q, Natarajan G, Yang M, Wen P-C, Haloi N, Tajkhorshid E, Camara AKS, Kwok WM. A Phosphomimetic Mutation S215E in VDAC1 Interferes with Hexokinase Binding. Biophysical Journal 118(3):184a DOI: 10.1016/j.bpj.2019.11.1124 2020, Biophysical Society 2020 conference, San Diego Ca.
179. Feng J, Cheng Q, Natarajan G, Camara AKS, Kwok WM. Multi-modal Actions of BAX and BTSA1 on Mitochondrial Bioenergetics and Membrane Integrity. Biophysical Journal 118(3):449a DOI: 10.1016/j.bpj.2019.11.2507 Biophysical Society 2020 conference, San Diego Ca.
180. Zaré A, Li K, Malas KM, Heisner JS, Mishra J, Stowe DF, Kwok WM, and Camara AKS. Delayed Pathophysiology of Mild Traumatic Brain Injury: The Diminished Role of Ca2+ Buffering Capacity of Cerebral Mitochondria. Biophysical Journal 118(3):445a
181. DOI: 10.1016/j.bpj.2019.11.2490 2020, San Diego Ca.
182. Kim J, Zimmerman MA, Stowe DF, Camara A, Hagen C, McGraw J, Mathison AJ, Zimmermann MT, Lombek G, Urrutia RA and Hong JC. Regular hepatic reperfusion in porcine donation after circulatory death experimental model: The effects of ischemia-reperfusion injury on epigenetic and mitochondrial function. Submitted to the 14th Annual American Surgical Association meeting in Washington DC, 2020.
183. Yang M, Li K, Sun J, Stowe DF, Tajkhorshid, Kwok WM, Camara AKS. Knockout of VDAC1 in H9c2 cells promotes tBHP-induced cell apoptosis through decreased mitochondrial HK II binding and enhanced glycolytic stress. Submitted to Experimental Biology 2020 conference, San Diego, CA.
184. Mishra J, Kwok WM, Fitts RH* and Camara AKS. Exercise‐induced Increase in Hexokinase II ‐Mitochondria Association Reduces Cardiac Ischemia‐ Reperfusion Injury in Rats. Submitted to Experimental Biology 2020 conference, San Diego, CA.
185. Li K, Roth E, Kwok WM, Pan B, Camara AKS. Long Term Cognitive Impairment and Increased Inflammation following Mild Traumatic Brain Injury using the CHIMERA Model. Submitted to Experimental Biology 2020 conference, San Diego, CA.
186. PROGRAMMATIC DEVELOPMENT OF RESEARCH
187. Research collaborations at the Medical College of Wisconsin:
188. My research to date focuses on: 1) the role of mitochondrial ROS production and the Na+/H+ exchanger in cold ischemia and reperfusion injury and the potential relevance of ROS scavengers in cardiac preservation; 2) the regulation of mitochondrial ion transport (hydrogen, potassium and calcium fluxes), mitochondrial pH, membrane potential and the effects of derangement in these processes in the potential the activation mitochondrial damage and cell injury; 3) the molecular mechanisms, for example, posttranslational modification of key mitochondrial outer and inner membrane proteins critical to oxidative stress-mediated mitochondrial dysfunction and cell death.
189. I have in the years broaden my research by collaborating with faculties at the Medical College of Wisconsin, University of Wisconsin-Milwaukee and Marquette University. I also have collaboration with a former mentee who is now an Assistant Professor at Michigan State University. With my strong background in mitochondrial biology, I have been able to collaborate with faculties and postdoctoral fellows who have expressed interest in incorporating mitochondria in their research. In this endeavor, I have helped faculties and postdoctoral fellows with preliminary data for grants and data for publications. Some of the preliminary data provided crucial results to test hypotheses or verify feasibility of research plans; these efforts have led to funded grants and numerous collaborative publications. The collaborations have also given me the opportunity to mentor graduate students at Marquette University and UW-Milwaukee, and to serve on dissertation committees. My level of involvement with students at MCW and beyond the campus, underscores my fervent philosophy of collaboration as the cornerstone for success in academic research. I intend to continue to use my expertise to foster further collaboration with new PIs, and to assist wherever possible, to contribute to the development of novel ideas towards grants.
190. R01 Grant 04-01-17: My research on mitochondria has entered a new phase with focus on molecular mechanisms to elucidate the etiology of mitochondrial dysfunction following oxidative/nitrosative stress. In this effort, I teamed up with Dr. Wai-Meng Kwok, Professor of Anesthesiology and Pharmacology and Toxicology and Dr. Emad Tajkhorshid Professor of Pharmacology, Biophysics and Computational Biology at The College of Medicine, University of Illinois Urbana-Champaign, on a 3-PI (Multiple PI mechanism) proposal to investigate the mechanisms underlying transformation of the mitochondrial voltage dependent anion channel (VDAC) between protective and lethal states during oxidative/nitrosative stress. Specifically, we postulate that phosphorylation of certain amino acid residues regulate the gating properties of the channel, its conformational structure and overall impact on mitochondrial bioenergetics and cell survival/death following oxidative stress. The proposal uses state-of-the-art techniques including gene editing (CRISPR-Cas9 to conduct knock-ins of VDAC), proteomics and molecular dynamic simulations to determine how mitochondria can transform from being protective to becoming lethal to the cell. These novel approaches will provide, hitherto, not reported mechanisms to show the role of VDAC in cell protection or death and their potential therapeutic utility against oxidative stress.
191. AHW Grant 07-01-17: The Advance Healthier Wisconsin (AHW) grant is part of the financial package that was given to our new Chair, Dr. Cynthia Lien, to expand our basic science research into the area of mild Traumatic Brain Injury (mTBI), with emphasis on mitochondria. I was selected to lead this initiative (PI), because of my expertise and strong track record in mitochondrial biology. In this effort, I work with three other faculty members, all of whom are essential to the success of this initiative. These faculty members are Dr. Wai-Meng Kwok, an expert in ion channel electrophysiology, Dr. Christopher Pawela, Assistant Professor of Anesthesiology, an expert in brain imaging, and Dr. Bin Pan, an Assistant Professor of Anesthesiology, an expert in neuro-electrophysiology at the tissue level. Our team of investigators, with complementary skills, is poised to lead this research to a new frontier in better understanding the manifestation of mTBI and its impact on the health of individuals afflicted with the disease. The project title is: "Identifying molecular mechanisms underlying TBI-a path to novel therapeutic opportunities". The progression of molecular changes following mTBI leads to multiple physiological changes including mitochondrial dysfunction and neuronal degeneration. Despite the tremendous effort invested on TBI research, the ability to mitigate chronic neurological deficits in TBI patients remains limited. The objective of this proposal is to unravel the underlying molecular mechanisms that are the underpinnings of mTBI. To accomplish this task, we will use an integrative multiscale (top-down) hierarchical approach, which involves brain imaging, electrophysiology at the tissue and mitochondria level, and mitochondrial bioenergetics and other functions. We will also use the latest proteomic approaches that may shed some new insights into how trauma impacts mitochondrial function based on its effect on specific mitochondrial proteins critical in bioenergetics. My overarching goal for this initiative, as a PI, is to create an environment that would spur further collaboration amongst faculties in our department, and to work together to submit multiple R01 proposals, based on complementary skills.
192. PPG 03/01/15-02/28/20 Dr. Zeljko Bosnjak, Program Project Grant; Projector Director. I play a crucial role in the current PPG. My role is to coordinate the experiments in Project III. The project has both experimental (Dr. Camara) part and computational modeling (Dr. Ranjan Dash) component. I have worked very closely with Dr. Ranjan Dash, Associate Professor Marquette University-MCW BME program; we both contribute equally towards the project. My lab provided important preliminary data for Project III that was needed for computational modeling and for the success of the project. There are two postdoctoral fellows, one experimentalist and the other a computational biologist who responsible for the bulk of work proposed in the PPG. The experimental part of the project relies heavily on role of mitochondria in cardiac function during exposure to volatile anesthetics, and the potential impact of type II diabetes in impeding volatile anesthetic-mediated protection against ischemia and reperfusion injury. A substantial progress in this project has been the work I supervise in the experimental component of the PPG.
193. Other collaborations
194. Marquette University & Medical College of Wisconsin Department of Biomedical Engineering: I continue to pursue my interest in understanding the biophysical changes that contribute to mitochondrial dysfunction in ischemia and reperfusion injury. In the past five years, I have collaborated with Dr. Ranjan Dash (computational biologist), to study mitochondrial function in normal and in diseased heart. Our goal is to understand the biophysical and biochemical factors involved in mitochondrial handling of pH, cations, and reactive oxygen (ROS) in cardiomyocytes using experimental and computational modeling approaches to provide a unique perspective in this dynamic process. Our studies have also focused on understanding how these biophysical and biochemical factors individually and collectively influence and modulate mitochondrial function. This research objective was the basis of our recently completed multiple (2-PI) R01 proposal (NIH-NHLBI HL095122; 2010-2015). We are currently working on a new proposal, an extension of this proposal based on our continued iterative experimental-computational strategy, to understand how mitochondria Ca2+ buffering is central in the cross-talk between mitochondrial Ca2+ and ROS under normal and oxidative stress conditions.
195. Department of Division of Pulmonary and Critical Care Medicine Medical College of Wisconsin: I have worked with Dr. Elizabeth Jacobs on several of her grants, which are designed to establish the role of mitochondrial dysfunction in ischemia and reperfusion injuries and diagnose these injuries using novel minimally invasive techniques based upon deranged mitochondrial function. With novel means to detect apoptosis and redox injury in vivo, the proposed studies examined correlations between altered mitochondrial bioenergetics, severity of changes to lung structure or function and the potential of imaging methods to track these injuries. I have assisted in data interpretation and My collaboration contributed to the recently expired funded grants: a VA Merit grant (IBX001681A) and NIH R01 (R01 HL116530). My collaboration with Dr. Jacobs continues on her VA Merit grant which has just been resubmitted for review. This grant is entitled Role of mitochondrial dysfunction in hyperoxia-induced pulmonary vascular endothelial injury". If funded, my major scientific role in this project will be to provide oversight in the acquisition and interpretation of data regarding mitochondrial function. I also have experience with optical imaging to determine the redox state of tissues, a crucial approach in this study. As noted above, Dr. Jacobs and I have worked on separate projects. One of our articles has recently been published in the journal Shock, entitled: Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging (PMID: 28915216).
196. Department of Medicine and Physiology: I collaborate with Dr. Andre Sorokin, Professor of Medicine and Physiology, on the role of mitochondrial p66shc transgenic rats in ischemia and reperfusion injury. The transgenic rats showing KO of p66shc or telomerase are generated using ZFN, TALEN and CRISPR-Cas9 site directed nuclease technologies under by Dr. Aron Geurts Director of MCW Rat Transgenic Facility. We have shown that use of the p66shc KO rats recapitulates the cardioprotection we observed when p66shc translocation to mitochondria was inhibited (PLoS One 9 (12):e113534, 2014 PMID: 25436907). Use of these transgenic animal models in addition to use of targeted pharmacological agents could provide us the opportunity to explore novel mechanisms for understanding mitochondrial-mediated cell death or apoptosis. We have acquired enough data from recent experiments using the transgenic rats in ischemia and reperfusion studies to write a manuscript or be used as preliminary data for a potential grant.
197. I have worked with Dr. Andreas Beyer, Assistant Professor of Medicine and Physiology, on numerous projects, and I also helped train his postdoctoral fellow, Dr. Karima Ait-Aissa, on her work the contributing role of mitochondria in the etiology of human coronary artery disease. Some of the studies conducted in my lab were and/or will be presented at national meetings (e.g. "Increased mitochondrial DNA damage results in loss of complex IV catalytic subunit expression with elevated levels of mitochondrial fission/fusion markers in Coronary artery disease"). Dr. Ait-Aissa also recently submitted a Scientist Development Grant to the AHA. Her grant had a decent score, but was not enough for funding. I have also worked closely with Dr. Beyer on his mitochondria telomerase knock out rats and their susceptibility to ischemia and reperfusion injury. Our collaboration on these projects has led to several pending publications (e.g. Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease submitted to J. American Heart Association, 2018) and preliminary data for potential collaborative grant proposals.
198. Department of Surgery: I collaborate with Dr. Johnny Hong, the Chief Division of Transplant Surgery, Froedtert Hospital and Medical College of Wisconsin, and his team of surgeons looking at mitochondria function following liver ischemia and ischemia and reperfusion. Specifically, Dr. Hong's team is interested in optimizing preservation solutions for organ storage before transplant, with minimal impact on mitochondrial functional integrity. Their objectives include the potential beneficial effects of the "ideal preservation solution" on protecting mitochondrial function that would in turn provide better preservation of livers for transplant. This work is akin to several of my earlier studies where I showed that hypothermia even though protects against cardiac ischemia and reperfusion injury, it also leads to deleterious reactive oxygen species production from mitochondria (see Bibliography #27 and #41). Therefore, creating the ideal preservation solutions with minimal impact on mitochondria function is desirable. My role in Dr. Hong's project is to advise our research team on the design of protocols for mitochondrial studies, and to aid in interpretation of the results. An abstract on our novel findings is submitted to the Experimental Biology conference, entitled Mitochondrial Function in Swine Liver Procured after Cardiac Death, scheduled to take place in April. Some preliminary data from the mitochondrial studies will be used in conjunction with other data for submission of an AHW grant proposal.
199. Blood Research Institute/Comprehensive Center for Bleeding Disorders: I collaborate with Dr. Shawn Jobe. Both Dr. Jobe and I are currently interested in how cyclophilin D (CypD) and the mitochondrial calcium uniporter function to regulate mitochondrial calcium entry in the setting of necrosis and apoptosis. My lab has extensive experience in the detailed analysis of cytosolic and mitochondrial calcium fluxes in cardiomyocytes and we have recently utilized CypD null mice provided by Dr. Jobe's lab to address a novel question regarding better understanding of mitochondrial Ca2+ handling in normal and pathophysiological conditions. I am a co-investigator on Dr. Jobe's recent R01 submission. I continue to provide him assistance in investigating the role of mitochondrial calcium dynamics (influx and efflux) in the regulation of platelet activation. The title of his R01 grant proposal is: "Procoagulant platelet mechanisms and function".
200. Research collaborations at the University of Wisconsin-Milwaukee:
201. University of Wisconsin-Milwaukee Department of Engineering: I have recently embarked on research collaboration with Dr. Masha Ranji, Founder and Director of the UW-Milwaukee Biophotonics Lab, and Associate Professor of Engineering at UW-Milwaukee, Department of Engineering. Dr. Ranji is an expert in optical imaging and image processing of tissue metabolism, especially in the 3-D model. We have used this novel approach to show for the first time a 3-D view of mitochondrial bioenergetics, ROS production and cellular and mitochondrial Ca2+ homeostasis in the ex vivo perfused heart. This approach shows for the first time a 3-D heterogeneous distribution of mitochondrial redox state in the heart during ischemia and reperfusion injury. This work has been published in recently in IEEE J Transl Eng Health Med entitled "Optical Cryo-imaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and its Alteration during Ischemia and Reperfusion" (PMID: 27574574), and it was recognized for its novelty and was the Editor's pick for that publication issue. In a recent ongoing project in collaboration with Dr. Meetha Medhora Professor in the Department of Pulmonary Medicine at the Medical College of Wisconsin, we have used similar cryoimaging to assess the impact of whole thorax low dose irradiation versus whole body irradiation on cardiac function and mitochondrial redox state in rats before and after cardiac ischemia and reperfusion injury. This work has been published in J. Biomed Opt entitled: Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury (PMID: 29352564). Dr. Ranji and I continue to work together on other projects, including the lungs and kidney. We have recently submitted a multiple PI Letter of intent (Grant title: Investigating metabolism and vascular dysfunction in cardiovascular ischemia reperfusion injury) to an American Heart Association RFA on a Multidisciplinary research broadly related to cardiovascular function, cardiovascular disease, and stroke. I have also served, and continue to serve, as a mentor and an adviser to her postdoctoral and pre-doctoral students (see list of students mentored above). An R15 grant was recently submitted based on our collaborative effort. The grant is titled: "Predicting cardiovascular ischemic injury propagation border zone using optical imaging and computational modeling".
202. Department of Biological Science Marquette University: I am working with Dr. Robert Fitts an Emeritus Professor of Biology on understanding how moderate level of exercise impacts the heart and protects against ischemic stress. Specifically, this project seeks to elucidate the role of calcium homeostasis during exercise, from the organismic level to the mitochondria associated membrane region of the cell in the protection against ischemia and reperfusion-mediated injury. We have submitted a multiple PI grant titled "Exercise-Training Induced Protective Mechanisms in the Stressed Heart" in this collaborative partner.
 

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