CURRICULUM VITAE
Aron Geurts PhD
Aron Geurts PhD
Professor
Department of Physiology
Department of Physiology
OFFICE ADDRESS: |
Health Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4526 |
Fax: 414-955-6515 |
EDUCATION: |
09/1995 - 06/1999 B.S. Genetics and Cell Biology, University of Minnesota - Twin Cities, Minneapolis, MN |
09/2001 - 04/2006 Ph.D. Molecular, Cellular, Developmental Biology and Genetics, University of Minnesota - Twin Cities, Minneapolis, MN |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
06/2006 - 07/2009 Postdoctoral Fellow - Human Molecular Genetics Center, Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
08/2006 Rat Pronuclear Microinjection Training, The Transgenic Animal Core, University of Michigan |
FACULTY APPOINTMENTS: |
07/01/2009 - 07/01/2012 Assistant Professor, Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
07/01/2012 - 06/30/2021 Associate Professor, Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
07/01/2021 - Present Professor with Tenure, Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
AWARDS AND HONORS: |
2007 Fellowship in Physiological Genomics, American Physiological Society |
2011 New Innovator Award, Office of the Director of the National Institutes of Health |
2015 Steven Cullen Health Heart Scholar Award, Cardiovascular Center - MCW |
2019 Community of Innovators award, Medical College of Wisconsin |
2023 Outstanding Graduate School Educator, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2012 - Present American Physiological Society (Regular member) |
2016 - Present Genome Writers Guild (Founder and Treasurer) |
2017 - Present International Society for Transgenic Technology (Regular member) |
2021 - Present American Heart Association (General Professional) |
2022 - Present Medical College of Wisconsin (Society of Research Excellence) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
2007 - Present Nucleic Acids Research |
2008 - Present Physiological Genomics |
2011 - Present PLoS One |
2011 - Present Science Translational Medicine |
2011 - 2013 Frontiers in Physiological Genomics |
2011 - Present Cell and Molecular Life Sciences |
2013 - Present Genes to Cells |
2013 - Present The Prostate |
2013 - Present Methods |
2013 - Present eLife |
2014 - Present Disease Models and Mechanisms |
2015 - Present Scientific Reports |
2016 - Present Human Gene Therapy |
2016 - Present Disease Models and Mechanisms |
2017 - Present Nature Communications |
2017 - Present BMC Biology |
2017 - Present Stem Cell Reports |
2018 - Present PLoS Genetics |
2018 - Present Nature Reviews Nephrology |
2020 - Present Journal of Advanced Research |
2020 - Present Renal Failure |
2020 - Present Journal of Biomedical Research |
2021 - Present BMC Biology |
2021 - Present BMC Biotechnology |
2021 - Present Genes |
2021 - Present European Journal of Pharmacology |
2022 - Present Scientific Reports |
2023 - Present Animals |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2012 - 2018 Voting member, Institutional Biosafety Committee, Medical College of Wisconsin |
2014 - 2016 Research faculty representative, Cardiovascular Center Roadmap Advisory Board, Medical College of Wisconsin |
2014 - 2020 Reviewer, Research Affairs Committee, Medical College of Wisconsin |
2015 - 2016 Chair, Research Affairs Committee, Medical College of Wisconsin |
2016 - 2018 Chair, IDP Directors Group subcommittee on curriculum change, Medical College of Wisconsin |
2016 - 2019 Department of Physiology representative, IDP Directors Group, Medical College of Wisconsin |
2016 - 2018 Chair, Institutional Biosafety Committee, Medical College of Wisconsin |
2019 - Present Course Director, Course Directors Group, IDP |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2011 - 2015 Member, External Advisory Committee, Mayo Translational Polycystic Kidney Disease Center |
2013 - 2015 Organizer, Organizing Committee, Rat Genomics and Models Meeting, Cold Spring Harbor |
Grant Reviewer, ZDA1 JXR - G (02) IDENTIFICATION OF GENE VARIANTS FOR ADDICTION RELATED TRAITS BY NEXT-GEN SEQUENCING IN MODEL ORGANISMS SELECTIVELY BRED FOR ADDICTION TRAITS (UH2/UH3), NIH |
Grant Reviewer, ZDA1 JXR - G (10) CUTTING-EDGE BASIC RESEARCH AWARDS (CEBRA) (R21), NIH |
Grant Reviewer - stage 1, ZRG1 RCCS - L (70) NIH DIRECTOR'S NEW INNOVATOR AWARD PROGRAM (DP2), NIH |
Grant Reviewer, ZDA1 GXM - A (09) CUTTING-EDGE BASIC RESEARCH AWARDS (CEBRA) (R21), NIH |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Aron Geurts, Modeling complex disease in rodent models using cutting-edge genome engineering technologies, Nephrology Grand Rounds, MCW, 08/20/2014 |
Aron Geurts, Principles of Engineering: Digital Editing of Genomes, Joint Biomedical Engineering Seminar Series, MCW, 09/25/2015 |
Aron Geurts, CRISPR gene editing, High school, 05/15/2017 |
Aron Geurts, Practical Applications of CRISPR, Vasculata 2019, MCW, 07/15/2019 |
Aron Geurts, Uncovering novel mechanisms for complex traits, Precision Cardiovascular Medicine Signature Group, Cardiovascular Center MCW, 12/03/2019 - Present |
Regional |
Aron Geurts, Breaking into the rat genome with a jumping gene and a pair of scissors, Mayo Research Clinic, 07/09/2010 |
Aron Geurts, Empowering genetic manipulation inthe rat model to uncover human disease mechanisms, Seminar series, University of Louisville, Louisville, KY, 03/15/2012 |
Aron Geurts, Student-invited Lecture: Empowering rodent models through targeted engineering directly in the embryo, Annual Mouse Genomic Symposium, Northwestern Universtiy, Chicago, IL, 05/13/2012 |
Aron Geurts, Empowering laboratory models through genetic engineering to acclerate discovery, Nutritional Sciences Seminar Series, University of Wisconsin, Madison, WI, 11/28/2012 |
Aron Geurts, Empowering genetic manipulation in model organisms to uncover human disease mechanisms, 6th Aquatic Animal Models for Human Disease/Midwest Zebrafish Meeting, University of Wisconsin - Milwaukee, 07/01/2013 |
Aron Geurts, Editing Genomes, MSOE, 07/10/2014 |
Aron Geurts, Edting Genomes: GMO in biomedical research, Wisconsin Lutheran College, 07/22/2014 |
Aron Geurts, Zinc-Finger Nucleases, TALENs, and CRISPR... (Oh my!) Genome engineering in a brave new world, Science Cafe, UWM Innovation Center, 11/18/2014 |
Aron Geurts, Transforming a laboratory species through genome engineering, Genome Engineering 2017, Minneapolis, MN, 06/14/2017 |
Aron Geurts, CRISPR: Engineering Genomes in the Lab and Clinic, Milwaukee Academy of Medicine, Milwaukee, WI, 03/20/2018 |
Aron Geurts, CRISPR/Cas9: how we get from, GWG Satellite event, The Ohio State University, 03/30/2018 |
San Diego, CA, Gene Editing in Rats: what We’ve Learned from Unlocking the Genome of a Valuable Laboratory Species, University of Minnesota, 10/02/2019 |
National |
Aron Geurts, New strategies to target the rat genome - role of zinc finger nucleases, Council on High Blood Pressure Reseearch, Chicago, IL, 09/01/2009 |
Aron Geurts, Howard Jacob, Targeted gene disruption in rats using zinc finger nucleases, Animal Models and Their Value in Predicting Efficacy and Toxicity, The New York Academy of Sciences, New York, NY, 09/15/2011 |
Aron Geurts, The state of the art of genetic engineering in laboratory rats, Kidney Week 2011: Advances in Research Conference: MicroRNA, Philadelphia, PA, 11/09/2011 |
Aron Geurts, Gene editing in rats: advances and opportunities, UTHSC, 09/29/2014 |
Aron Geurts, Empowering the Laboratory Rat through Advances in Genome Engineering, IU O'Brien Center Annual Retreat, IUPUI, 04/28/2015 |
Aron Geurts, Genetic Engineering in rat models: progress and challenges for addiction and behavioral research, NIDA Center for GWAS in Outbred Rats Annual Retreat, Chicago, 06/29/2015 |
Aron Geurts, 10 years of manipulating the rat genome – where are we and what have we learned?, Physiological Genomics Symposium, 04/24/2017 |
Aron Geurts, Hybrid rat diversity program (HRDP): A rat resource for systems genetics, Complex Trait Consortium Meeting, San Diego, CA, 06/09/2019 |
International |
Aron Geurts, Targeted modification of the rat genome using zinc-finger nucleases, Rat Genomics & Models Meeting, Wellcome Trust Sanger Center, Hinxton, U.K., 12/2008 |
Aron Geurts, Targeted heritable gene disruption in the rat by embryo injection of designed zinc finger nucleases, Funcional Annotation of Genomes, Banff, Alberta, Canada, 04/25/2009 |
Aron Geurts, Targeted modification of the rat genome using zinc-finger nucleases, FASEB, New Orleans, LA, 04/2009 |
Aron Geurts, Heritable, targeted gene disruption in the rat after embryo microinjection of designed zinc-finger nucleases, Conferenece on Genome Engineering, Minneapolis, MN, 06/2009 |
Aron Geurts, Gene knockout in the rat embryo using designed zinc-finger nucleases, 5th Annual Quebec Transgenic Research Network Symposium, Montreal, Quebec, Canada, 11/2009 |
Aron Geurts, That was yesterday, this is tomorrow – building the next generation of disease models, University of Edinburgh, 03/16/2010 |
Aron Geurts, Prospects for the rat as a disease model through genetic engineering, 6th International ISP Congress and 14th International SHR Symposium, Montreal, Quebec, Canada, 09/22/2010 - 09/25/2010 |
Aron Geurts, Howard Jacob, The International Society for Transgenic Technologies (ISTT), Tampa Bay, FL, 10/25/2011 |
Aron Geurts, Empowering laboratory models through genetic engineering to accelerate discovery, ZFN workshop, Heidelberg, Germany, 02/27/2013 - 03/01/2013 |
Aron Geurts, Empowering the laboratory rat through advances in genetic engineering, IUPS 2013, Birmingham, United Kingdom, 07/21/2013 - 07/26/2013 |
Aron Geurts, Targeted Nuclease Technology: Empowering genetic engineering beyond the mouse, Conference on Transposition & Genome Engineering, Budapest, Hungary, 09/18/2013 - 09/21/2013 |
Aron Geurts, New transgenic technologies: Applications of TALENs, ZFNs and CRISPR/Cas9, EMBO 2013, Amsterdam, The Netherlands, 09/21/2013 - 09/24/2013 |
Aron Geurts, The impact of maternal in utero environment on salt-induced hypertension in the SS rat, FASEB, San Diego, 04/27/2014 |
Aron Geurts, New Models of Human Physiological Disorders Generated by Genome Editing in the Rat, American Society for Nephrology Kidney Week, San Diego, 11/06/2015 |
Aron Geurts, Seven years of knocking out rat genes – where are we and what have we learned?, Rat Genomics and Models Meeting, CSHL, 12/07/2015 |
Aron Geurts, 10 years of manipulating the rat genome - where are we at and what have we learned?, Experimental Biology 2017, Chicago, IL, 04/24/2017 |
Aron Geurts, Rat models of arterial hypertension (engineering the Dahl S rat genome), INSERM TRIP meeting, Nantes, France, 05/11/2017 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
National |
Geurts AM, Advancing genetic engineering technology beyond murine systems, Pioneer Symposium, Washington, DC, 09/13/2012 - 09/14/2012 |
Sara J Holditch, Alessandro Cataliotti, Aron M. Geurts, Yasuhiro Ikeda, Determining the physiologic effect of B-Type Natriuretic Peptide on cardio-renal homeostasis, American Society of Gene & Cell Therapy 2013, Salt Lake City, Utah, 05/15/2013 - 05/18/2013 |
Fan Fan, Ying Ge, Sydney Murphy, Aron M. Geurts, Howard Jacob, Richard J. Roman, CYP4A1 transgenic rats generated using Sleeping Beauty transposon system restores the impaired myogenic responses in the afferent arteriole of Dahl S rats, Council on High Blood Pressure Research, New Orleans, LA, 09/11/2013 - 09/14/2013 |
Harrison MD, Grzybowski MN, Utschig-Samuels LE, Schneider ED, Miller J, Geurts AM, Genetic Engineering Strategies: Novel Tools for Control of Gene Expression in Cells and Animal Models, Rat Genomics and Models Meeting, Cold Spring Harbor, NY, 12/2013 |
Aron M. Geurts, Pengyuan Liu, Alex Dayton, Nathan Rudemiller, Meredith Skelton, Terry Kurth, Jason Klotz, Michael Grzybowski, David Mattson, Mingyu Liang, and Allen W. Cowley, Jr., The impact of maternal in utero environment on salt-induced hypertension in the SS rat, EB 2014, San Diego, 04/2014 |
S. Rasmussen, S. Mallanna, W. Tan, D. Carlson, S. Fahrenkrug, A. Lerch-Gaggl , P. North , L. Wilson, S. Duncan, A. Geurts, Restoration of Liver Function Following Transplantation of Healthy Hepatocytes into the Fah -/- IL2rg-/- Rat Model, Experimental Biology 2015, Boston, MA, 04/2015 |
Megan Constans, Diana Escobar-Zarate, Jessica Smith, Aron M. Geurts, Vicente E. Torres, Peter C. Harris, Characterization of two Pkd1 rat models, ASN 2016, Chicago, IL, 2016 |
Oleg Palygin, Anna Manis, Vladislav Levchenko, Daria Zaika, Nicholas Burgraff, Aron Geurts, Matthew Hodges and Alexander Staruschenko, Kcnj10 (Kir 4.1) Knockout in Dahl SS Rats Determines the Expression of Kcnj10 and Kcnj16 Proteins in Brain and Kidney, Experimental Biology 2017, Chicago, IL, 04/22/2017 - 04/26/2017 |
Maribel Marquez, Chris McDermott-Roe, Mike Grzybowski, Daniel Helbling, David P. Dimmock, James W. Verbsky, Aron M. Geurts, Evaluation of Patient-Specific MTERF4 Variants in Gene-Edited Human iPSC-derived Cardiomyocytes, 2017 |
Melinda R Dwinell, Rebecca Schilling, Michael Grzybowski, Anne Temple, Allison Zappa, Lynn Lazcares, Jessica Niebuhr, Shawn Kalloway, Jamie Foeckler, Akiko Takizawa, Aron M Geurts, Gene Editing Rat Resource Center (GERRC): Rat models for heart, lung, blood, and sleep disorder studies, HBPR 2018, Chicago, IL, 09/06/2018 - 09/09/2018 |
MARGARET WONG-RILEY, DANDAN WANG, MICHAEL GRZYBOWSKI, LIANWEI MU, DAVID BAKER, SUJEAN CHOI, AND ARON M. GEURTS, Flexible and inducible BDNF gene knockdown in rat neurons, SfN 2018, San Diego, CA, 11/03/2018 - 11/07/2018 |
Aron M. Geurts, Angela Lemke, Aimee Steffenhagen, Jeff De Pons, Anne Temple, Rebecca R. Schilling1, fer R. Smith, Monika Tutaj, Michael N. Grzyowski, Marek Tutaj, Jyothi Thota, Kristin Nord, Matthew J. Hoffman, Stacy Zacher, Kent Brodie, Ryan Spellecy, Arthur R. Derse, Mary Shimoyama, Melinda R. Dwinell, Somatic Cell Genome Editing Program: Dissemination and Coordinating Center, Keystone CRISPR meeting, Banff, Canada, 02/08/2020 - 02/13/2020 |
T.C. Rich, N. Annamdevula, D.J. Pleshinger, A.M. Geurts, and S.J. Leavesley, Novel hyperspectral imaging approaches allow 3D measurement of cAMP signals in localized subcellular domains, AKAP 2020, Virtual, 10/06/2020 - 10/08/2020 |
Rebecca A. Slick, Jennifer A. Tinklenberg, Hui Meng, Margaret Beatka, Mariah Prom, Emily Ott, Federica Montanaro, Liwen Zhang, Henk Granzier, Edna Hardeman, Aron Geurts, Michael W. Lawlor, Proteomic profiling in Nemaline Myopathy to identify molecular phenotypes that contribute to disease heterogeneity, New Directions in Biology and Disease of Skeletal Muscle Conference, virtual, 10/30/2020 - 10/31/2020 |
Jennifer Tinklenberg, Rebecca Slick, Jessica Sutton, Mark Vanden Avond, Margaret Beatka, Mariah Prom1, Emily Ott, Hui Meng, Michael Grzybowski, James Heisner, Jacob Ross, Julien Ochala, Kristen J Nowak, Liwen Zhang, Aron Geurts, David Stowe, Federica Montanaro, Michael W Lawlor, Mouse models of nemaline myopathy display structural and functional abnormalities of mitochondria, New Directions in Biology and Disease of Skeletal Muscle Conference, virtual, 10/30/2020 - 10/31/2021 |
Alexandria M Szalanczy, Osborne Seshie, Emily Goff, Michael Grzybowski, Aron M. Geurts, & Leah Solberg Woods, Keratinocyte-Associated Protein 3 knock-out rats exhibit increased body weight and fat pad weight, TOS 2020, virtual, 11/02/2020 - 11/06/2020 |
Arthur P. Arnold, Xuqi Chen, Michael Gryzbowski, Lynn Lazcares, Akiko Takizawa, Laurent Vergnes, Helen Skaletsky, David C Page, Karen Reue, Melinda Dwinell, and Aron M. Geurts, “Four Core Genotypes” Rats: Comparing XX and XY Rats with the Same Type of Gonads to Detect Sex Chromosome Effects that Cause Sex Differences in Physiology and Disease, ORWH SCORE meeting, virtual, 12/16/2020 - 12/17/2020 |
Jennifer A. Tinklenberg, Rebecca A. Slick, Jessica Sutton, Hui Meng, Margaret Beatka, Mark Vanden Avond, Mariah Prom, Emily Ott, Liwen Zhang, Federica Montanaro, James Heisner, Rafael Toro, Gina Ravenscroft, Edna Hardeman, Julian Ochala, Kristin Nowak, Aron Geurts, David Stowe, Blake Hill, Michael W. Lawlor, Acta1 mouse models of nemaline myopathy display structural and functional abnormalities of mitochondria, 2022 MDA Clinical & Scientific Conference, Nashville, TN, 03/13/2022 - 03/16/2022 |
Rebecca A. Slick, Jennifer A. Tinklenberg, Jessica Sutton, Liwen Zhang, Hui Meng, Margaret Beatka, Mark Vanden Avond, Mariah Prom, Emily Ott, Federica Montanaro, James Heisner, Rafael Toro, Henk Granzier, Aron Geurts, David Stowe, Blake Hill, Michael W. Lawlor, Proteomic profiling of Neb cKO mice reveals metabolic changes, 2022 MDA Clinical & Scientific Conference, Nashville, TN, 03/13/2022 - 03/16/2022 |
Chen X, Ryan JM, Harley VR, Lazcares L, Takizawa A, Dwinell MR, Geurts AM, Arnold AP, Hormone levels, gonadal histology, body growth in Four Core Genotypes-like rats dissociating hormonal and sex chromosomal effects on sexual differentiation, OSSD 16th Annual Meeting, Marina del Rey, CA, 05/02/2022 - 05/05/2022 |
Mohanroy T, Sengelaub DR, Chen X, Grisham W, Dwinell MR, Geurts AM, Arnold AP, Brain Sexual Dimorphisms and Estrous Cycling in the Four Core Genotypes-like Rats, OSSD 16th Annual Meeting, Marina del Rey, CA, 05/02/2022 - 05/05/2022 |
Xuqi Chen, Melinda Dwinell, Aron Geurts, and Arthur P. Arnold, Hormone levels and body growth in Four Core Genotypes-like rats dissociating hormonal and sex chromosome effects on sexual differentiation, OSSD 16th Annual Meeting, Marina del Rey, CA, 05/02/2022 - 05/05/2022 |
Michael Grzybowski, Mark Vanden Avond, Kristie Usa, Jason Klotz, Medical Coll of
Wisconsin, Milwaukee, WI; Oleg Palygin, Medical Univ of SC, Charleston, SC; Melinda R Dwinell, MEDICAL
COLLEGE OF WISCONSIN, Milwaukee, WI; Allen W Cowley Jr., MEDICAL COLLEGE WISCONSIN, Milwaukee,
WI; Alexander Staruschenko, Univ of South Florida, Tampa, FL; Mingyu Liang, MEDICAL COLLEGE OF
WISCONSIN, Milwaukee, WI; Aron M Geurts, Transgenic Cre Drivers For Harvesting Podocytes And Endothelial Cells From Dahl Salt-sensitive
Rats, HBPR Scientific Sessions, San Diego, CA, 09/07/2022 - 09/10/2022 |
AM Szalanczy, M Fitzpatrick, T Bui, C Dyson, S Eller, G Giorgio, E Goff, J Landry, C Scott, O Seshie, M Grzybowski, J Klotz, AM Geurts, EE Redei, J L Weiner, & LC Solberg Woods, Investigating Krtcap3 as a novel stress gene, APS Summit 2023, Long Beach, CA, 04/20/2023 - 04/23/2023 |
Atrayee Ray, Cary Stelloh, Chun Yang, Yong Liu, Aaron M. Geurts, Allen Cowley, Anne Kwitek, Pengyuan Liu, Mingyu Liang, Andrew S Greene, Sridhar Rao, Chromatin accessibility landscape of blood pressure relevant kidney tissues by ATAC-seq, HBPR Scientific Sessions, Boston, MA, 09/07/2023 - 09/10/2023 |
Aron M. Geurts, Monika Tutaj, Jeffrey De Pons, Pengyuan Liu, and Anne E. Kwitek, Rat ReMap Initiative at the Rat Genome Database a resource of publicly accessible transcriptomic and epigenomic data for laboratory rats, HBPR Scientific Sessions, Boston, MA, 09/07/2023 - 09/10/2023 |
Aron M. Geurts, Chun Yang, Emily Novak, Bhavika Therani, Yong Liu, Andrew S. Greene, Sridhar Rao, Mingyu Liang, Pengyuan Liu & Allen W. Cowley, Jr., RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal Disease, HBPR Scientific Sessions, Boston, MA, 09/07/2023 - 09/10/2023 |
Qiongzi Qiu, Yong Liu, Hong Xue, Jing Liu, Bhavika Therani, Kristie Usa, Jing Huang, Andrew Greene, Sidhar Rao, Aron M. Geurts, Allen Cowley, Pengyuan Liu, Mingyu Liang, Shared and distinct cellular and molecular landscapes of cardiac left ventricle injurydamage in three models of hypertension: Insights from single-nucleus RNA sequencing, HBPR Scientific Sessions, Boston, MA, 09/07/2023 - 09/10/2023 |
Brody Smith, Lashodya V Dissanayake, Adrian Zietara, Vladislav Levchenko, Aron M. Geurts, Oleg Palygin, Alexander Staruschenko, Effects of carnitine palmitoyltransferase 2 (CPT2) deficiency on blood pressure regulation and renal homeostasis, HBPR Scientific Sessions, Boston, MA, 09/07/2023 - 09/10/2023 |
Aron M. Geurts, Akiko Takizawa, Lynn Lazcares, Monika Tutaj, Rebecca Schilling, Anne E. Kwitek, Bina Joe, Melinda R. Dwinell, Hybrid Rat Diversity Program (HRDP): A rat resource for mapping complex traits, Complex Trait Consortium, University of Colorado, 09/22/2023 - 09/23/2023 |
Philip M. Boone, Ricardo Harripaul, Rachita Yadav, Ryan L. Collins, Michael Grzybowski, Matthew O. Larson, Paulina Gonzalez Tovar, John Lemanski, Maris Handley, Celine de Esch, Kiana Mohajeri, James F. Gusella, Derek J.C. Tai, Sandra Sanchez-Roige, Benjamin Currall, Christopher McGraw, Abraham Palmer, Ryan Doan, Aron M. Geurts, Michael E. Talkowski, Structural variant alteration to Aberrant recursive splicing associated with ADHD, WCPG 2023, Montreal, Canada, 10/10/2023 - 10/14/2023 |
International |
Aron Geurts, Germline transposon mutagenesis and applications to forward-genetic screens and chromosome engineering using the Sleeping Beauty transposon system, 5th VW Stiftung meeting on conditional mutagenesis and mouse models, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, 2004 |
Aron Geurts, Progress on insertional mutagenesis in the mouse using the Sleeping Beauty transposon system and design of a forward-genetic screen, Mouse Molecular Genetics Meeting, Cold Spring Harbor, New York, NY, 2004 |
Aron Geurts, Progress on a forward-genetic insertional mutagenesis screen in the mouse using the Sleeping Beauty transposon system, 3rd Annual International Conference on Transposition and Animal Biotechnology, Minneapolis, MN, 06/2005 |
Aron Geurts, Biology of Genomes meeting, Rat Genomics & Models Meeting, Cold Spring Harbor Laboratory, New York, NY, 12/2005 |
Aron Geurts, Prospects for disease gene discovery using transposable elements, Biology of Genomes Meeting, Cold Spring Harbor Laboratory, New York, NY, 03/2007 |
Aron Geurts, Unlocking the rat genome with transposable elements, Fifth Annual International Conference on Transposition and Animal Biotechnology, Minneapolis, MN, 06/2007 |
Aron Geurts, Transposon knockouts by high throughput gene trapping in the rat, Rat Genomics & Models Meeting, Cold Spring Harbor Laboratory, New York, NY, 12/2007 |
Aron Geurts, The rat knockout project: Unravelling complex human disease through advances in rat knockout technology, Rat Genomics & Models Meeting, Cold Spring Harbor Laboratory, New York, NY, 12/2009 |
Aron Geurts, Faster, cheaper and more elegant methods for engineering the rat genome, Rat Genomics & Models Meeting, Cold Spring Harbor Laboratory, New York, NY, 12/2011 |
Endres B, Moreno C, Lombard JK, Jacob HJ, Geurts AM, A potential protective role for Plekha7, an adherens junction protein, against renal damage, Experimental Biology 2012, San Diego, CA, 04/21/2012 - 04/25/2012 |
Casati M, Hoffman M, Schilling R, Flister M, Geurts AM, Dwinell MR, Lazar J, Jacob JH, Moreno C, Characterization of a Comt knockout rat for blood pressure and associated phenotypes, Council for High Blood Pressure Research 2012, Washington, DC, 09/19/2012 - 09/22/2012 |
Endres B, Sarkis AB, Priestley J, Casati M, Hoffman M, Lazar J, Schilling R, Dwinell MR, Lombard JH, Cowley AJ, Mattson D, Moreno C, Geurts AM, Jacob HJ, GWAS candidate knockout in rats reveals a potential role for ERK/MAPK signaling in hypertension, Council for High Blood Pressure Research 2012, Washington, DC, 09/19/2012 - 09/22/2012 |
Mattson DL, Lund H, Guo C, Geurts AM, Jacob HJ, Genetic deletion of CD247 in dahl salt-sensitive (SS) rats attentuates hypertension and renal damage, Council for High Blood Pressure Research 2012, Washington, DC, 09/19/2012 - 09/22/2012 |
Aron Geurts, Progress on targeted nuclease-mediated engineering of the rat genome, Rat Genomics & Models, Cambridge, U.K., 12/07/2012 - 12/10/2012 |
Bradley Endres, Jessica Priestley, Oleg Palygin, Matthew Hoffman, Carol Moreno, Julian Lombard, Howard Jacob, Aron Geurts, Plekha7, a candidate gene for human hypertension, plays a critical role in the regulation of intracellular calcium, Experimental Biology 2013, San Diego, CA, 04/21/2013 - 04/25/2013 |
Shauna A Rasmussen, Sunil Mallanna, Stephen A. Duncan, Wengfan Tan, Daniel F. Carlson, Scott C. Fahrenkrug, Aron M. Geurts, Transplanted healthy hepatocytes engraft and repopulate the Fah -/- IL2rg-/- rat model of liver failure, Rat Genomics and Models Meeting 2013, Cold Spring Harbor, NY, 12/11/2013 - 12/14/2013 |
Bradley Endres, Jessica R.C. Priestley, Oleg Palygin, Matthew Hoffman, Mike Grzybowski, Julian H. Lombard, Alexander Staruschenko, Carol Moreno, Howard J. Jacob, Aron M. Geurts, Plekha7, a candidate gene for human hypertension, plays an functional role in the regulation of blood pressure and renal function, Rat Genomics and Models Meeting 2013, Cold Spring Harbor, NY, 12/11/2013 - 12/14/2013 |
Harrison MD, Grzybowski M, Utschig-Samuels L, Schneider L, Miller J, Geurts A, Genetic Engineering Strategies: Novel Tools for Control of Gene Expression in Cells and Animal Models, Rat Genomics and Models Meeting 2013, Cold Spring Harbor, NY, 12/11/2013 - 12/14/2013 |
M. Grzybowski, T. Stodola, S. Pietrzak, and A. Geurts, In vitro validation and comparison of targeted nucleases in mouse and rat cells, Rat Genomics and Models Meeting 2013, Cold Spring Harbor, NY, 12/11/2013 - 12/14/2013 |
Jason Klotz, Rebecca Schilling, Melinda Dwinell, Jozef Lazar, Aron M Geurts, Michael Grzybowski, Angela Lemke, Jocelyn Miller, Anne Temple, Allison Zappa, Chieh-Ti Kuo, Lynn Lazcares, Shawn Kalloway, Jamie Foeckler, Akiko Takizawa, Jozef Lazar, Howard J Jacob1,, Aron M Geurts, Melinda Dwinell, Jason Klotz,2, Rebecca Schilling1,22, Melinda Dwinell1,2, Jozef Lazar1,3, Aron M Geurts1,2, Michael Grzybowski1,2, Angela Lemke1,2, Jocelyn Miller1,2, Anne Temple1,2, Allison Zappa1,2, Chieh-Ti Kuo1,2, Lynn Lazcares1,2, Shawn Kalloway1,4, Jamie Foeckler1,4, Akiko Takizawa1,2, Jozef Lazar1, Howard J Jacob1,2, Aron M Geurts1,2, Melinda Dwinell1,2, ISTT 2016, Prague, Czech Republic, 03/20/2016 - 03/23/2016 |
Aron M Geurts, Rebecca Schilling, Michael Grzybowski, Anne Temple, Allison Zappa, Lynn Lazcares, Jessica Niebuhr, Shawn Kalloway, Jamie Foeckler, Akiko Takizawa, Andrew S. Greene, Allen W Cowley, Jr., Mingyu Liang, David Mattson, Melinda R Dwinell, Mechanisms of blood pressure control: impact of rat genomic and transgenic model resources, Complex Trait Consortium meeting, Glasgow, UK, 06/20/2018 - 06/22/2018 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2012 - 2018 Voting Member, Instiutional Biosafety Committee, Medical College of Wisconsin |
2013 - 2021 Member, Physiology PhD program admissions, Physiology, Medical College of Wisconsin |
2014 - 2020 Appointed Member, Research Affairs Committee, Medical College of Wisconsin |
2014 - 2015 Elected Member, Graduate Studies Council Awards Committee, Medical College of Wisconsin |
2015 - 2016 Chair, Research Affairs Committee, MCW |
2016 - 2018 Chair, Interdisciplinary Program in Biomoedical Sciences - subcommittee on curriculum change, Medical College of Wisconsin |
2016 - 2018 Chair, Institutional Biosafety Committee, Medical College of Wisconsin |
2016 - 2019 Physiology representative, Interdisciplinary Program in Biomedical Sciences - Program Directors Group, Medical College of Wisconsin |
2017 - 2018 Member, Ad Hoc committee on graduate student education, Medical College of Wisconsin |
2022 - Present Member, Committee on Self-Imposed Regulatory Burden, Medical College of Wisconsin |
2023 - Present Member, Course Evaluation Committee |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
2017 - 2020 Lecturer Molecules & Cells |
Graduate Student Education |
2010 - Present Translational Genetics |
2011 - 2022 Physiological Genomics - Course Director |
2016 - 2019 Classical Genetics |
2019 - Present Foundations in Biomedical Sciences III, Co-course Director |
2020 - Present Functional Genomics - Course Director |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
PhD Students Advised |
Bradley Endres, MCW, 2010 - 2014 Characterization of Genes Found in Human Hypertension Genome-Wide Association Studies, Clinical Pharmacy Specialist - Hematology/Oncology at Clement J. Zablocki VA Medical Center |
Shauna Rasmussen, MCW, 2012 - 2017 Characterization and utilization of immune compromised rats as an allogeneic rat hepatocyte transplant model, Assistant Academic Research Scientist at Emory University, Emory University |
Maribel Marquez, MCW, 2015 - 2020 Evaluation of patient specific variants of uncertain significance through genome engineered model systems, As of 2023: Senior Scientist, Allector |
Mark Vanden-Avond, MCW, 2020 - Present |
PhD Committees |
Eric Weh, MCW, 2011 - 2014 Investigating the molecular mechanisms of Peters’ Plus Syndrome, Research Investigator, Ophthalmology and Visual Sciences, University of Michigan |
Andrew Weyer, MCW, 2012 - 2016 |
Allison Beaty-Sarkis, MCW, 2012 - 2014 Genetic Dissection of Blood Pressure in the Dahl SS Rat Using Sequence Data, Head of Product and Customer Service, Arcensus |
Kirk Twaroski, MCW, 2012 - 2016 Transient
Inhibition
of
Canonical
WNT
Signaling
Mediated
by
FGF2-‐
Induced
Expression
of
NKD1
is
Required
for
Hepatic
Specification, Kirk Twaroski - Product Manager - FUJIFILM Cellular Dynamics |
Shraddha Nayak, MCW, 2013 - 2015 Development of a Novel Adora2b Transgenic Rat
and Role of A2B Adenosine Receptors in
Hypertension, Biomedical Illustrator, self employed |
Nathan Rudemiller, MCW, 2014 - 2015 Utilizing Genetic Manipulation to Elucidate Inflammatory Mechanisms of Salt-Sensitive Hypertension, Researcher, BioAgilytix |
Madeleine Puissant, MCW, 2014 - 2015 Identifying molecular determinants of cellular and whole animal CO2/pH chemosensitivity in the rat: major roles for medullary raphe neuromodulators and inwardly rectifying potassium channels, MD/PhD-trained neurophysiologist and emergency medicine physician, Maine Health |
Mark Paterson, MCW, 2015 - 2019 miR-146b-5p and sex-specific
renocardiac pathology in the 5/6Nx rat, Assistant Professor, Concordia University |
Jennifer Tinklenberg, MCW, 2019 - 2022 Mitochondrial Abnormalities in Mouse
Models of Muscle Disease, Postdoctoral Fellow, Paccak Lab, University of Minnesota |
Nnamdi Uche, MCW, 2019 - 2023 A personalized medicine approach for disease modeling using human iPSC-derived cardiomyocytes that reverses redox-dependent mitochondrial dysfunction and prevents cancer treatment-related cardiotoxicity, Postdoctoral Researcher at Northwestern University |
Rebecca Slick, MCW, 2019 - 2022 Utilizing omics data to identify candidate biomarkers in congenital muscle diseases, Post-doctoral fellow in the Ervasti Lab at UMN |
Nathan Meinhardt, MCW, 2020 - Present |
Natalia Mathieu, MCW, 2022 - 2024 Role of β-arrestin2 in the Regulation of Blood Pressure
and Fluid Homeostasis in the Brain |
Jerrell Lovett, MCW, 2022 - Present |
Postdoctoral Students |
Michael Harrison, M.D., Ph.D., MCW, 2012 - 2016 Mentor, Sr. Director, Strategic Initiatives & Community Engagement at BioForward |
Christopher McDermott-Roe, Ph.D., MCW, 2013 - 2017 Mentor, Senior Research Scientist at Broad Institute of MIT and Harvard |
PROGRAMMATIC DEVELOPMENTS: |
Educational Programs |
Faculty |
2017 - 2018 IDP shared curriculum |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Cui Z, Geurts AM, Liu G, Kaufman CD, Hackett PB. Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. J Mol Biol. 2002 May 17;318(5):1221-35. |
2. Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB. Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther. 2003 Jul;8(1):108-17. |
3. Clark KJ, Geurts AM, Bell JB, Hackett PB. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Genesis. 2004 Aug;39(4):225-33. |
4. Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB. Target-site preferences of Sleeping Beauty transposons. J Mol Biol. 2005 Feb 11;346(1):161-73. |
5. Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB. Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res. 2006;34(9):2803-11. PMCID: PMC1464413 |
6. Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab. 2012 Feb 08;15(2):201-8. PMCID: PMC3280886 |
7. Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol. 2006 Jun 26;6:30. PMCID: PMC1557845 |
8. Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA. Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet. 2006 Sep 29;2(9):e156. PMCID: PMC1584263 |
9. Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC. Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet. 2006 Nov 10;2(11):e169. PMCID: PMC1635535 |
10. Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H. Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R407-14. PMCID: PMC3602820 |
11. Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr. Efficient transgenic rat production by a lentiviral vector. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H881-94. |
12. Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ. Rab38 modulates proteinuria in model of hypertension-associated renal disease. J Am Soc Nephrol. 2013 Feb;24(2):283-92. PMCID: PMC3559491 |
13. Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ. Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. Physiol Genomics. 2013 Feb 04;45(3):110-8. PMCID: PMC3568879 |
14. Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE. Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome. 2007 May;18(5):338-46. |
15. Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z. Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J. 2013 Mar;27(3):930-41. PMCID: PMC3574282 |
16. Hackett CS, Geurts AM, Hackett PB. Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. Genome Biol. 2007;8 Suppl 1(Suppl 1):S12. PMCID: PMC2106846 |
17. Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 2009 Jul 24;325(5939):433. PMCID: PMC2831805 |
18. Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, NeuroBSIK Mouse Phenomics Consortium, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M. High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Genes Brain Behav. 2012 Oct;11(7):772-84. PMCID: PMC3508728 |
19. Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC. Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Res. 2011 Feb;20(1):29-45. PMCID: PMC3516389 |
20. Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C. Identifying multiple causative genes at a single GWAS locus. Genome Res. 2013 Dec;23(12):1996-2002. PMCID: PMC3847770 |
21. Taylor SB, Taylor AR, Markham JA, Geurts AM, Kanaskie BZ, Koenig JI. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. Physiol Behav. 2011 Aug 03;104(2):205-14. PMCID: PMC3081908 |
22. Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014 Jan;63(1):68-74. PMCID: PMC3868049 |
23. Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS. Creation and characterization of a renin knockout rat. Hypertension. 2011 Mar;57(3):614-9. PMCID: PMC3513323 |
24. Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Hypertension. 2011 Aug;58(2):303-9. PMCID: PMC3170043 |
25. Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ. Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. Physiol Genomics. 2013 Feb 04;45(3):110-8. PMCID: PMC3568879 |
26. Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. PMCID: PMC3920146 |
27. Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U. Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem Cells Int. 2011;2011:717069. PMCID: PMC3184415 |
28. Rangel Filho A, Lazar J, Moreno C, Geurts AM, Jacob HJ. Transgenic rescue and gene knockout demonstrate that a mutation in Rab38 modulates proteinuria and albuminuria in hypertensive FHH rats. JASN. 2012 in press |
29. Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL, PhysGen Knockout Program. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension. 2014 Mar;63(3):559-64. PMCID: PMC3945169 |
30. Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z. Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons. Nat Protoc. 2014 Apr;9(4):810-27. |
31. Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z. Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. Nat Protoc. 2014 Apr;9(4):794-809. |
32. Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z. Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons. Nat Protoc. 2014 Apr;9(4):773-93. |
33. Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM. HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. Hypertension. 2014 Sep;64(3):541-50. PMCID: PMC4324599 |
34. Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Proc Natl Acad Sci U S A. 2014 Sep 02;111(35):12817-22. PMCID: PMC4156702 |
35. Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ. CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. Cancer Res. 2014 Nov 15;74(22):6419-29. PMCID: PMC4247541 |
36. Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC Genet. 2014 Dec 05;15:135. PMCID: PMC4266191 |
37. Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr. Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. Hypertension. 2015 Feb;65(2):447-55. PMCID: PMC4289102 |
38. Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. PLoS One. 2014;9(11):e112878. PMCID: PMC4232417 |
39. Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 01;308(5):R379-90. PMCID: PMC4346760 |
40. Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee. 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. J Cardiovasc Transl Res. 2015 Jun;8(4):269-77. PMCID: PMC4475456 |
41. Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H. Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. Genetics. 2015 Jun;200(2):423-30. PMCID: PMC4492369 |
42. Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Hypertension. 2015 May;65(5):1111-7. PMCID: PMC4412596 |
43. Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. |
44. Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M. Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. Kidney Int. 2015 Oct;88(4):796-803. PMCID: PMC4589441 |
45. Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Hypertension. 2015 Jul;66(1):199-210. PMCID: PMC4467451 |
46. Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M. Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. Physiol Genomics. 2016 Jan;48(1):62-72. PMCID: PMC4757026 |
47. Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G. Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum. Neurogastroenterol Motil. 2016 Jan;28(1):64-73. PMCID: PMC4688076 |
48. Hegan PS, Ostertag E, Geurts AM, Mooseker MS. Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. Cytoskeleton (Hoboken). 2015 Oct;72(10):503-16. PMCID: PMC4715625 |
49. Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Purinergic Signal. 2015 Dec;11(4):519-31. PMCID: PMC4648794 |
50. Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O. Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. J Vis Exp. 2015 Jun 10(100):e52734. PMCID: PMC4545029 |
51. Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH. The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. PMCID: PMC4796617 |
52. Cowley AW Jr, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension. 2016 Feb;67(2):440-50. PMCID: PMC4713301 |
53. Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Sci Rep. 2016 Feb 26;6:22154. PMCID: PMC4768167 |
54. Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. J Am Heart Assoc. 2016 Feb 17;5(2). PMCID: PMC4802485 |
55. Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR. Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. J Appl Physiol (1985). 2016 May 01;120(9):1070-81. PMCID: PMC4855209 |
56. Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP. Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. Free Radic Biol Med. 2016 Mar;92:141-151. PMCID: PMC5047058 |
57. Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ. The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. J Biol Chem. 2016 Jul 15;291(29):14939-53. PMCID: PMC4946913 |
58. Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. J Clin Invest. 2016 Jul 01;126(7):2533-46. PMCID: PMC4922697 |
59. McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. Am J Physiol Renal Physiol. 2016 Oct 01;311(4):F793-F804. PMCID: PMC5142236 |
60. Geurts AM, Ekker SC. Gene Editing: Practical Application in the Lab. Hum Gene Ther. 2016 Jun;27(6):417-8. PMCID: PMC5583549 |
61. Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A. ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. J Hypertens. 2016 Sep;34 Suppl 1:e39. |
62. Aitman T, Dhillon P, Geurts AM. A RATional choice for translational research? Dis Model Mech. 2016 Oct 01;9(10):1069-1072. PMCID: PMC5087836 |
63. Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER. Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. Exp Lung Res. 2017 Feb;43(1):38-48. PMCID: PMC5831175 |
64. Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A. Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. Breast Cancer Res Treat. 2017 Aug;165(1):53-64. PMCID: PMC6404538 |
65. Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O. Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2017 Aug 01;313(2):F163-F173. PMCID: PMC5582897 |
66. Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 01;49(9):496-504. PMCID: PMC5625267 |
67. Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S. In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. Hum Mol Genet. 2017 Dec 01;26(23):4541-4555. PMCID: PMC5886163 |
68. Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. JCI Insight. 2017 Sep 21;2(18). PMCID: PMC5621918 |
69. Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH. Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats. J Vis Exp. 2017 Dec 05(130). PMCID: PMC5755532 |
70. Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M. miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. EMBO Mol Med. 2018 Mar;10(3). PMCID: PMC5840545 |
71. Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M. Genome-wide map of proximity linkage to renin proximal promoter in rat. Physiol Genomics. 2018 May 01;50(5):323-331. PMCID: PMC6008118 |
72. Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J. Characterization of Coding/Noncoding Variants for <i>SHROOM3</i> in Patients with CKD. J Am Soc Nephrol. 2018 May;29(5):1525-1535. PMCID: PMC5967772 |
73. Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A. A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. J Am Soc Nephrol. 2018 Jul;29(7):1917-1927. PMCID: PMC6050934 |
74. Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV. A Hypermorphic <i>Nfkbid</i> Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8<sup>+</sup> T Cells in NOD Mice. J Immunol. 2018 Oct 01;201(7):1907-1917. PMCID: PMC6143397 |
75. Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M. Tissue-specific effects of targeted mutation of Mir29b1 in rats. EBioMedicine. 2018 Sep;35:260-269. PMCID: PMC6156712 |
76. Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M. MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. J Am Soc Nephrol. 2018 Oct;29(10):2518-2528. PMCID: PMC6171279 |
77. Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A. Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Am J Physiol Renal Physiol. 2018 Oct 01;315(4):F1091-F1097. PMCID: PMC6230750 |
78. Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW. Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. J Neuropathol Exp Neurol. 2018 Aug 01;77(8):665-672. PMCID: PMC6044411 |
79. Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA. A Screen Using iPSC-Derived Hepatocytes Reveals NAD<sup>+</sup> as a Potential Treatment for mtDNA Depletion Syndrome. Cell Rep. 2018 Nov 06;25(6):1469-1484.e5. PMCID: PMC6289059 |
80. Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A. The p52 isoform of SHC1 is a key driver of breast cancer initiation. Breast Cancer Res. 2019 Jun 15;21(1):74. PMCID: PMC6570928 |
81. Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA. Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency. Lab Invest. 2019 Oct;99(10):1572-1592. |
82. Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F. Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury. J Pharmacol Exp Ther. 2019 Aug;370(2):206-217. PMCID: PMC6636243 |
83. Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM. Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury. Front Cardiovasc Med. 2019;6:31. PMCID: PMC6454001 |
84. Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M. Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploinsufficiency in Dahl Salt-Sensitive Rats. Hypertension. 2019 Aug;74(2):313-322. PMCID: PMC6620137 |
85. Berenpas F, Weerdesteyn V, Geurts AC, van Alfen N. Long-term use of implanted peroneal functional electrical stimulation for stroke-affected gait: the effects on muscle and motor nerve. J Neuroeng Rehabil. 2019 Jul 10;16(1):86. PMCID: PMC6621964 |
86. . Retraction of "Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains". Stem Cells Dev. 2013 Oct 15;22(20):2813. |
87. Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Habenular TCF7L2 links nicotine addiction to diabetes. Nature. 2019 Oct;574(7778):372-377. PMCID: PMC9851388 |
88. Olson RJ, Hopp K, Wells H, Smith JM, Furtado J, Constans MM, Escobar DL, Geurts AM, Torres VE, Harris PC. Synergistic Genetic Interactions between <i>Pkhd1</i> and <i>Pkd1</i> Result in an ARPKD-Like Phenotype in Murine Models. J Am Soc Nephrol. 2019 Nov;30(11):2113-2127. PMCID: PMC6830782 |
89. Paterson MR, Geurts AM, Kriegel AJ. miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease. Kidney Int. 2019 Dec;96(6):1332-1345. PMCID: PMC6941490 |
90. Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Mol Psychiatry. 2021 Jun;26(6):1909-1927. PMCID: PMC7483293 |
91. Fan F, Geurts AM, Pabbidi MR, Ge Y, Zhang C, Wang S, Liu Y, Gao W, Guo Y, Li L, He X, Lv W, Muroya Y, Hirata T, Prokop J, Booz GW, Jacob HJ, Roman RJ. A Mutation in <i>γ</i>-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. J Am Soc Nephrol. 2020 Apr;31(4):687-700. PMCID: PMC7191921 |
92. Garcia J, Flood VH, Haberichter SL, Fahs SA, Mattson JG, Geurts AM, Zogg M, Weiler H, Shi Q, Montgomery RR. A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9. Res Pract Thromb Haemost. 2020 Jan;4(1):64-71. PMCID: PMC6971331 |
93. Guo H, Xu D, Kuroki M, Lu Z, Xu X, Geurts A, Osborn JW, Chen Y. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Free Radic Biol Med. 2020 May 20;152:787-796. |
94. Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y. Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms. Hypertension. 2020 Mar;75(3):859-868. PMCID: PMC7035167 |
95. Shi Q, Mattson JG, Fahs SA, Geurts AM, Weiler H, Montgomery RR. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Blood Adv. 2020 Jan 14;4(1):55-65. PMCID: PMC6960468 |
96. Rasmussen SA, Daenzer JMI, MacWilliams JA, Head ST, Williams MB, Geurts AM, Schroeder JP, Weinshenker D, Fridovich-Keil JL. A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism. J Inherit Metab Dis. 2020 May;43(3):518-528. PMCID: PMC7318568 |
97. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. Cell Rep. 2019 Dec 03;29(10):3073-3086.e5. PMCID: PMC6914223 |
98. McDermott-Roe C, Lv W, Maximova T, Wada S, Bukowy J, Marquez M, Lai S, Shehu A, Benjamin I, Geurts A, Musunuru K. Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes. JCI Insight. 2019 Nov 14;4(22). PMCID: PMC6948852 |
99. Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A. Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome Frontiers in Cell and Developmental Biology. 23 June 2020;8. |
100. Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M. Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes. J Am Soc Nephrol. 2020 Jul;31(7):1539-1554. PMCID: PMC7350998 |
101. Prokop JW, Chhetri SB, van Veen JE, Chen X, Underwood AC, Uhl K, Dwinell MR, Geurts AM, Correa SM, Arnold AP. Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat. Biol Sex Differ. 2020 May 12;11(1):28. PMCID: PMC7216353 |
102. Johnston JG, Speed JS, Becker BK, Kasztan M, Soliman RH, Rhoads MK, Tao B, Jin C, Geurts AM, Hyndman KA, Pollock JS, Pollock DM. Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion. Hypertension. 2020 Jun;75(6):1624-1634. PMCID: PMC7228023 |
103. Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG. The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137<sup>+</sup> FOXP3<sup>+</sup> Regulatory CD4 T Cells. J Immunol. 2020 Jun 01;204(11):2887-2899. PMCID: PMC7296588 |
104. Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS. Interaction between Mas1 and AT1R<inf>A</inf> contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats PLoS ONE. April 2020;15(4). |
105. Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS. Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. PLoS One. 2020;15(4):e0232067. PMCID: PMC7179868 |
106. Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A. Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an <i>MYH6</i> Head Domain Variant Associated With Hypoplastic Left Heart Syndrome. Front Cell Dev Biol. 2020;8:440. PMCID: PMC7324479 |
107. Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM. UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Sci Rep. 2020 Jul 21;10(1):12019. PMCID: PMC7374577 |
108. Mehrotra P, Ullah MM, Collett JA, Myers SL, Dwinell MR, Geurts AM, Basile DP. Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2020 Nov 01;319(5):F796-F808. PMCID: PMC7789982 |
109. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation Frontiers in Immunology. 4 September 2020;11. |
110. Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020;11:2180. PMCID: PMC7500101 |
111. Dwinell MR, Geurts AM. Integrating biology with rat genomic tools The Laboratory Rat. 1 January 2019:811-825. |
112. Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Keppel T, Zemaj J, Cherian-Shaw M, Gundry RL, Geurts AM, Dwinell MR, Mattson DL. Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury. Hypertension. 2021 Jan;77(1):228-240. PMCID: PMC9732708 |
113. Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA. Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing Transgenic Research. 2021. |
114. Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM. Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. Int J Mol Sci. 2020 Dec 13;21(24). PMCID: PMC7764018 |
115. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Erratum: Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation (Cell Reports (2019) 29(10) (3073–3086.e5), (S2211124719314810), (10.1016/j.celrep.2019.11.010)) Cell Reports. 2 February 2021;34(5). |
116. Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA. Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing. Transgenic Res. 2021 Feb;30(1):11-21. |
117. Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation. Cell Rep. 2021 Feb 02;34(5):108725. PMCID: PMC7923249 |
118. Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A. p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli. Life Sci. 2021 Aug 15;279:119661. PMCID: PMC8265215 |
119. Miller B, Kostrominova TY, Geurts AM, Sorokin A. Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy. Int J Mol Sci. 2021 May 15;22(10). PMCID: PMC8155973 |
120. Annamdevula N, Geurts A, Leavesley SJ, Rich TC. Hyperspectral imaging approaches to characterize the distribution and expression of FRET in tissues isolated from a novel transgenic rat expressing a FRET-based probe Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021;11649. |
121. Leavesley SJ, Annamdevula N, Geurts A, Pleshinger DJ, Rich TC. Assessing drug-cell and drug-tissue interactions through spectral FRET imaging Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021;11624. |
122. Yu W, Haque I, Venkatraman A, Menden HL, Mabry SM, Roy BC, Xia S, Prokop JW, Umar S, Geurts AM, Sampath V. SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. Cell Mol Gastroenterol Hepatol. 2022;13(2):425-440. PMCID: PMC8688179 |
123. Barron M, Hayes H, Fernando DG, Geurts AM, Kindel TL. Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats. J Gastrointest Surg. 2022 Aug;26(8):1607-1618. PMCID: PMC9444920 |
124. Dwinell M, Takizawa A, Lazcares L, Tutaj M, Schilling R, Geurts A, Kwitek A. Hybrid Rat Diversity Program (HRDP): A rat resource for mapping complex traits. FASEB J. 2022 May;36 Suppl 1. |
125. Hoffman MJ, Takizawa A, Jensen ES, Schilling R, Grzybowski M, Geurts AM, Dwinell MR. <i>Btg2</i> mutation induces renal injury and impairs blood pressure control in female rats. Physiol Genomics. 2022 Jul 01;54(7):231-241. PMCID: PMC9208437 |
126. Szalanczy AM, Giorgio G, Goff E, Seshie O, Grzybowski M, Klotz J, Roberts M, Geurts AM, Redei EE, Solberg Woods LC. Keratinocyte-associated Protein 3May Participate in the Stress Response to Impact Adiposity FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1 May 2022;36. |
127. Adam RJ, Paterson MR, Grzybowski MN, Geurts AM, Kriegel AJ. Ovarian Hormone-Dependent miR-146b-5p Regulation of Plasminogen Activator Inhibitor-1 in Renal Epithelial Cells FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1 May 2022;36. |
128. Yunker L, Zemaj J, Geurts A, Kriegel A. Proximal Tubule-Specific Transgenic Overexpression of Peroxisome Proliferator-Activated Receptor Alpha Prevents the Development of Hypertension in Dahl Salt-Sensitive Rats FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1 May 2022;36. |
129. Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A. Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model iScience. 16 September 2022;25(9). |
130. Liang M, Cowley AW Jr, Greene AS, Geurts AM, Liu P, Liu Y, Rao S. Advancing Physiology with Expanded Multi-Omics. Function (Oxf). 2022;3(4):zqac031. PMCID: PMC9247404 |
131. Szalanczy AM, Goff E, Seshie O, Deal A, Grzybowski M, Klotz J, Chuang Key CC, Geurts AM, Solberg Woods LC. Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females Frontiers in Genetics. 21 September 2022;13. |
132. Zietara A, Spires DR, Juffre A, Costello HM, Crislip GR, Douma LG, Levchenko V, Dissanayake LV, Klemens CA, Nikolaienko O, Geurts AM, Gumz ML, Staruschenko A. Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats. Hypertension. 2022 Nov;79(11):2519-2529. PMCID: PMC9669134 |
133. Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A. Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model. iScience. 2022 Sep 16;25(9):104887. PMCID: PMC9418856 |
134. Blum SI, Taylor JP, Barra JM, Burg AR, Shang Q, Qiu S, Shechter O, Hayes AR, Green TJ, Geurts AM, Chen YG, Tse HM. MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. JCI Insight. 2023 Jan 24;8(2). PMCID: PMC9977297 |
135. Hong-Le T, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC. Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats. Diabetes. 2023 Jan 01;72(1):135-148. PMCID: PMC9797320 |
136. Szalanczy AM, Goff E, Seshie O, Deal A, Grzybowski M, Klotz J, Chuang Key CC, Geurts AM, Solberg Woods LC. <i>Keratinocyte-associated protein 3</i> plays a role in body weight and adiposity with differential effects in males and females. Front Genet. 2022;13:942574. PMCID: PMC9535360 |
137. Shafiee S, Jagtap J, Zayats M, Epperlein J, Banerjee A, Geurts A, Flister M, Zhuk S, Joshi A. Dynamic NIR Fluorescence Imaging and Machine Learning Framework for Stratifying High vs. Low Notch-Dll4 Expressing Host Microenvironment in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Feb 25;15(5). PMCID: PMC10000786 |
138. Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE. Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. <i>Toxics</i> 2022, <i>10</i>, 797. Toxics. 2023 Feb 16;11(2). PMCID: PMC9959763 |
139. Hess EM, Kassel SN, Simandl G, Raddatz N, Maunze B, Hurley MM, Grzybowski M, Klotz J, Geurts A, Liu QS, Choi S, Twining RC, Baker DA. Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat. J Neurosci. 2023 Mar 29;43(13):2349-2361. PMCID: PMC10072291 |
140. Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 Apr 01;210(7):935-946. PMCID: PMC10483376 |
141. Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics. 2022 Dec 18;10(12). PMCID: PMC9783591 |
142. Arnold AP, Chen X, Grzybowski MN, Ryan JM, Sengelaub DR, Mohanroy T, Furlan VA, Grisham W, Malloy L, Takizawa A, Wiese CB, Vergnes L, Skaletsky H, Page DC, Reue K, Harley VR, Dwinell MR, Geurts AM. A "Four Core Genotypes" rat model to distinguish mechanisms underlying sex-biased phenotypes and diseases. bioRxiv. 2023 Feb 10. PMCID: PMC9934672 |
143. Liu Y, Huang J, Pandey R, Liu P, Therani B, Qiu Q, Rao S, Geurts AM, Cowley AW Jr, Greene AS, Liang M. Robustness of single-cell RNA-seq for identifying differentially expressed genes. BMC Genomics. 2023 Jul 03;24(1):371. PMCID: PMC10316566 |
144. Gwin MS, Alexeyev MF, Geurts AM, Lee JY, Zhou C, Yang XM, Cohen MV, Downey JM, Barrington RA, Spadafora D, Audia JP, Frank DW, Voth S, Pastukh VV, Bell J, Ayers L, Tambe DT, Nelson AR, Balczon R, Lin MT, Stevens T. Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 01;325(2):L174-L189. PMCID: PMC10396227 |
145. Zietara A, Palygin O, Levchenko V, Dissanayake LV, Klemens CA, Geurts A, Denton JS, Staruschenko A. K<sub>ir</sub>7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2023 Aug 01;325(2):F177-F187. PMCID: PMC10393338 |
146. de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H. A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. bioRxiv. 2023 Sep 28. PMCID: PMC10197727 |
147. Hirata T, Fan F, Fan L, Amin G, White T, Geurts AM, Kojima N, Takahashi T, Miyata N, Williams J, Roman RJ. Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-induced Nephropathy. J Cardiovasc Pharmacol. 2023 Dec 01;82(6):445-457. PMCID: PMC10691661 |
148. Szalanczy AM, Giorgio G, Goff E, Seshie O, Grzybowski M, Klotz J, Geurts AM, Redei EE, Solberg Woods LC. Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with <i>Krtcap3</i>. Physiol Genomics. 2023 Oct 01;55(10):452-467. PMCID: PMC10642928 |
149. Slick RA, Tinklenberg JA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Granzier H, Geurts AM, Stowe DF, Hill RB, Lawlor MW. Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy. Am J Pathol. 2023 Oct;193(10):1528-1547. PMCID: PMC10548278 |
150. Tinklenberg JA, Slick RA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Hardeman EC, Geurts AM, Stowe DF, Hill RB, Lawlor MW. Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology. Am J Pathol. 2023 Oct;193(10):1548-1567. PMCID: PMC10548277 |
151. Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP. Deletion of Vβ3<sup>+</sup>CD4<sup>+</sup> T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8<sup>+</sup> T cells. Proc Natl Acad Sci U S A. 2023 Dec 05;120(49):e2312039120. PMCID: PMC10710095 |
152. Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. Physiol Genomics. 2024 Mar 01;56(3):265-275. PMCID: PMC10866620 |
153. Ray A, Stelloh C, Liu Y, Meyer A, Geurts AM, Cowley AW Jr, Greene AS, Liang M, Rao S. Histone Modifications and Their Contributions to Hypertension. Hypertension. 2024 Feb;81(2):229-239. PMCID: PMC11229175 |
154. Szalanczy AM, Fitzpatrick M, Beeson A, Bui T, Dyson C, Eller S, Landry J, Scott C, Grzybowski M, Klotz J, Geurts AM, Weiner JL, Redei EE, Solberg Woods LC. Chronic stress from adolescence to adulthood increases adiposity and anxiety in rats with decreased expression of Krtcap3 Frontiers in Genetics. 2023;14. |
155. Szalanczy AM, Fitzpatrick M, Beeson A, Bui T, Dyson C, Eller S, Landry J, Scott C, Grzybowski M, Klotz J, Geurts AM, Weiner JL, Redei EE, Solberg Woods LC. Chronic stress from adolescence to adulthood increases adiposity and anxiety in rats with decreased expression of <i>Krtcap3</i>. Front Genet. 2023;14:1247232. PMCID: PMC10844407 |
156. de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H. A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. Cell Genom. 2024 Apr 10;4(4):100527. PMCID: PMC11019364 |
157. Fitzpatrick M, Szalanczy A, Beeson A, Vora A, Scott C, Grzybowski M, Klotz J, Der N, Chen R, Geurts AM, Woods LCS. Protein-coding mutation in <i>Adcy3</i> increases adiposity and alters emotional behaviors sex-dependently in rats. bioRxiv. 2024 Jun 16. PMCID: PMC11195162 |
Books, Chapters, and Reviews |
1. Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K. Progress and prospects in rat genetics: a community view. Nat Genet. 2008 May;40(5):516-22. |
2. Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R. Generation of gene-specific mutated rats using zinc-finger nucleases. Methods Mol Biol. 2010;597:211-25. |
3. Geurts AM, Moreno C. Zinc-finger nucleases: new strategies to target the rat genome. Clin Sci (Lond). 2010 Jul 06;119(8):303-11. PMCID: PMC3549593 |
4. Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM. Gene targeting in the rat: advances and opportunities. Trends Genet. 2010 Dec;26(12):510-8. PMCID: PMC2991520 |
5. Dwinell MR, Lazar J, Geurts AM. The emerging role for rat models in gene discovery. Mamm Genome. 2011 Aug;22(7-8):466-75. PMCID: PMC3643810 |
6. Geurts AM, Balciunas D, Lajos M Vertebrate transgenesis by transposition. In: Advanced Protocols for Animal Transgenesis - and ISTT Manual. 2011. Springer, New York. Eds. Thom Saunders and Shirley Pease |
7. Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA. Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology. 2014 Jan;76 Pt B(0 0):250-8. PMCID: PMC3823679 |
