CURRICULUM VITAE
Carol L. Williams PhD
Carol L. Williams PhD
Professor
Department of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
BIBLIOGRAPHY |
Books, Chapters, and Reviews |
1. Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL. An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. Sci Signal. 2013 May 28;6(277):ra39. PMCID: PMC4278376 |
2. Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H. Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1591-600. PMCID: PMC3863549 |
3. Schuld NJ, Hauser AD, Gastonguay AJ, Wilson JM, Lorimer EL, Williams CL. SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers. Cell Cycle. 2014;13(6):941-52. PMCID: PMC3984317 |
4. Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL. The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. J Biol Chem. 2014 Mar 07;289(10):6862-6876. PMCID: PMC3945348 |
5. Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL. The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. Mol Cancer Res. 2014 Jan;12(1):130-42. PMCID: PMC4285378 |
6. Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB. Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. Mol Carcinog. 2015 Mar;54(3):203-15. PMCID: PMC4087083 |
7. Williams CL. A new signaling paradigm to control the prenylation and trafficking of small GTPases. Cell Cycle. 2013;12(18):2933-4. PMCID: PMC3875666 |
8. Wilson JM, Lorimer E, Tyburski MD, Williams CL. β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. Cancer Biol Ther. 2015;16(9):1364-74. PMCID: PMC4622671 |
9. Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL. The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. J Biol Chem. 2016 May 13;291(20):10948. PMCID: PMC4865938 |
10. Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. J Biol Chem. 2016 Mar 18;291(12):6534-45. PMCID: PMC4813585 |
11. Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL. Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. J Mol Biol. 2016 Dec 04;428(24 Pt B):4929-4945. PMCID: PMC5153279 |
12. Hollenbeck D, Williams CL, Drazba K, Descartes M, Korf BR, Rutledge SL, Lose EJ, Robin NH, Carroll AJ, Mikhail FM. Clinical relevance of small copy-number variants in chromosomal microarray clinical testing. Genet Med. 2017 Apr;19(4):377-385. |
13. Bergom C, Hauser A, Lorimer EL, Li R, Mackinnon AC, Williams CL. SmgGDS splice variants: Potential novel targets for breast cancer therapeutics. J Clin Oncol. 2011 Sep 20;29(27_suppl):225. |
14. Zhao B, Hu W, Kumar S, Gonyo P, Rana U, Liu Z, Wang B, Duong WQ, Yang Z, Williams CL, Miao QR. The Nogo-B receptor promotes Ras plasma membrane localization and activation. Oncogene. 2017 Jun 15;36(24):3406-3416. PMCID: PMC5472485 |
15. Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017 Dec 14;36(50):6873-6883. PMCID: PMC5730474 |
16. Nithipatikom K, Gomez-Granados AD, Tang AT, Pfeiffer AW, Williams CL, Campbell WB. Erratum: Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells (Endocrinology (2012) 153 (29-41)) Endocrinology. May 2012;153(5):2531. |
17. Williams CL, Lennon VA. Striational autoantibodies: Paraneoplastic antibodies associated with thymoma and myasthenia gravis Clinical Immunology Newsletter. November 1991;11(11):161. |
18. Williams CL, Lennon VA, Pittelkow MR. Novel redistribution of myosin-containing filaments in cultured keratinocytes identified by a human monoclonal autoantibody. In Vitro Cell Dev Biol. 1989 May;25(5):397-401. |
19. Cikes N, Momoi MY, Williams CL, Howard FM Jr, Hoagland HC, Whittingham S, Lennon VA. Striational autoantibodies: quantitative detection by enzyme immunoassay in myasthenia gravis, thymoma, and recipients of D-penicillamine or allogeneic bone marrow. Mayo Clin Proc. 1988 May;63(5):474-81. |
20. Williams CL, Lennon VA, Momoi MY, Howard FM Jr. Serum antibodies and monoclonal antibodies secreted by thymic B-cell clones from patients with myasthenia gravis define striational antigens. Ann N Y Acad Sci. 1987;505:168-79. |
21. Williams CL, Lennon VA. Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin. J Exp Med. 1986 Oct 01;164(4):1043-59. PMCID: PMC2188418 |
22. Williams CL, Prasertsiriroj V, Dusanic DG. Trypanosoma lewisi: stage-specific surface antigens and exoantigens recognized by monoclonal antibodies. Exp Parasitol. 1986 Apr;61(2):252-60. |
23. Williams CL, Dusanic DG. Stage specific agglutination of Trypanosoma lewisi by monoclonal antibodies Federation Proceedings. 1984;43(6). |
24. Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL. Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3627-3636. PMCID: PMC7035473 |
25. Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM. Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol. Yale J Biol Med. 2022 Mar;95(1):45-56. PMCID: PMC8961707 |
26. Brandt AC, Koehn OJ, Williams CL. SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families. Front Mol Biosci. 2021;8:685135. PMCID: PMC8242357 |
27. Michalak DJ, Unger B, Lorimer E, Grishaev A, Williams CL, Heinrich F, Lösche M. Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558. Biophys J. 2022 Oct 04;121(19):3684-3697. PMCID: PMC9617131 |
28. Das AS, Sherry EC, Vaughan RM, Henderson ML, Zieba J, Uhl KL, Koehn O, Bupp CP, Rajasekaran S, Li X, Chhetri SB, Nissim S, Williams CL, Prokop JW. The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing. Front Cell Dev Biol. 2022;10:1033695. PMCID: PMC9714508 |
29. Koehn OJ, Lorimer E, Unger B, Harris R, Das AS, Suazo KF, Auger SA, Distefano MD, Prokop JW, Williams CL. GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS. J Biol Chem. 2023 Jun;299(6):104698. PMCID: PMC10206184 |
30. Justyna K, Das R, Lorimer EL, Hu J, Pedersen JS, Sprague-Getsy AM, Schey GL, Sieburg MA, Koehn OJ, Wang YC, Chen YX, Hougland JL, Williams CL, Distefano MD. Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues. Org Lett. 2023 Sep 15;25(36):6767-6772. PMCID: PMC10755972 |
31. Gleason N, Williams CL, Kowluru A. Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells Molecular and Cellular Endocrinology. 2023. |
32. Gleason N, Williams CL, Kowluru A. Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells. Mol Cell Endocrinol. 2024 Jan 15;580:112104. PMCID: PMC10842139 |
