CURRICULUM VITAE
Christopher M. Olsen PhD
Christopher M. Olsen PhD
Associate Professor
Department of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-7629 |
Email: colsen@mcw.edu |
EDUCATION: |
1990 - 1994 B.A. Psychology, Baylor University, Waco, TX |
1994 - 1998 M.S. Biology/minor Neuroscience, Texas Tech University, Lubbock, TX |
1998 - 2004 Ph.D. Neuropharmacology, University of Texas at Austin, Austin, TX |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2004 - 2008 Postdoctoral Fellow, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37240 |
FACULTY APPOINTMENTS: |
2008 - 2011 Research Instructor, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37240 |
2012 - Present Assistant Professor, Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank, Medical College of Wisconsin, Milwaukee, WI 53226 |
AWARDS AND HONORS: |
2013 Honorable Mention: Poster, Research Day: Medical College of Wisconsin |
2015 - 2016 Faculty Service Award-Medical Student Teaching, Medical College of Wisconsin |
2015 - 2016 Faculty Service Award-Library Committee, Medical College of Wisconsin |
2016 - 2019 Presidential Scholar Award, Medical College of Wisconsin |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
Recent Patents on CNS Drug Discovery |
Biochemical Pharmacology |
Neuropsychopharmacology |
WIREs Cognitive Science |
Addiction Biology |
Neuropharmacology |
Neuroscience Letters |
European Neuropsychopharmacology |
Synapse |
Psychopharmacology |
Behavioural Brain Research |
Journal of Visualized Experiments |
Scientific Reports |
Physiology and Behavior |
Psychology of Addictive Behaviors |
Ad-Hoc Reviewer |
Brain, Behavior, and Immunity |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2013 - Present Ad hoc member, 8 sessions, BRLE Study Section, National Institutes of Health |
2015 - Present Ad hoc member, 2 sessions, Special Emphasis Panel ZRG1 MDCN-B, National Institutes of Health |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2017 Ad hoc reviewer, 1 session, Swiss National Science Foundation (SNSF) |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, 2003 |
Dept. of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, 2005 |
Dept. of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, 2007 |
Dept. of Neuroscience, University of Puerto Rico School of Medicine, 2010 |
Dept. of Psychology, Indiana University-Purdue University at Indianapolis, 2010 |
Dept. of Pharmaceutical Sciences, University of Kentucky School of Medicine, 2011 |
Neuroscience Research Center, Medical College of Wisconsin, 2011 |
Dept. of Neuroscience, University of New Mexico School of Medicine, 2011 |
Integrative Neuroscience Research Center, Marquette University, 2012 |
Department of Physiology, Medical College of Wisconsin, 2015 |
Netherlands Institute for Neuroscience, 2016 |
Dept. of Biology and Neurosciences Institute, University of Texas at San Antonio, 2016 |
Brain Injury Research Day, Medical College of Wisconsin, 2017 |
Department of Pharmacology, University of Texas at Austin, 2017 |
Association of Clinical Research Professionals (ACRP) Symposium, 2017 |
Department of Biological Sciences, University of Wisconsin-Parkside, 2017 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Winter Conference on Brain Research (panel chair and speaker), 2008 |
Winter Conference on Brain Research (speaker), 2009 |
Winter Conference on Brain Research (panel chair and speaker), 2012 |
Winter Conference on Brain Research (panel chair and speaker), 2014 |
Winter Conference on Brain Research (panel chair and speaker), 2018 |
Regional |
W-SW Regional Conference for Comparative Endocrinology, 1997 |
W-SW Regional Conference for Comparative Endocrinology, 1998 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2012 - 2013 Member, Faculty Search Committee, Neuroscience Research Center, Medical College of Wisconsin |
2013 Traumatic Brain Injury Research Strategy Workgroup |
2015 - Present Member, Library Committee |
2016 - Present Member, Faculty Council |
2016 - Present Member, Strategic Library Council |
2016 - Present Chair, Library Committee |
2017 - Present Member, Interdisciplinary Graduate Program Recruitment Committee |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2014 - Present Symptoms Unit, 3-3.5 contact hours/year |
2015 - Present Principles of Drug Action, 5-8 contact hours/year |
Graduate Student Education |
2013 - Present Modern Drug Discovery, 3 contact hours/year/biennial |
2013 - Present Advanced Systems Neuroscience, 3-5 contact hours/year/biennial |
2014 - Present Fundamentals of Neuroscience, 3 contact hours/year |
2017 - Present Course Director: Pharmacology Student Seminar Series |
2017 - Present Course Director: Fundamentals of Neuroscience |
2017 - Present Ion Channels and Signal Transduction, 2 contact hours/year/biennial |
EXTRAMURAL TEACHING: |
Graduate Student Education |
1997 Texas Tech University, Lab Instructor, Comparative Animal Physiology Laboratory |
1999 - 2002 University of Texas at Austin, Stereotaxic Surgery Section of Graduate Pharmacology Methods, 4 contact hours/year |
2004 Vanderbilt School of Medicine, Systems Neuroscience, 2 contact hours |
2005 Vanderbilt School of Medicine, Systems Neuroscience, 2 contact hours |
2008 Vanderbilt School of Medicine, Systems Neuroscience, 2 contact hours |
Postdoctoral Fellow Education |
2009 - 2010 Vanderbilt School of Medicine, Associate Director: An Organ Systems Approach to Experimental Targeting of the Metabolic Syndrome |
Community/Lay Public |
2009 Summit High School, Winter Conference on Brain Research community outreach program |
2011 Summit Middle School, Winter Conference on Brain Research community outreach program |
2012 Albion Middle School, Winter Conference on Brain Research community outreach program |
2014 Heritage Christian School, Winter Conference on Brain Research community outreach program |
2015 Gallatin Gateway School, Winter Conference on Brain Research community outreach program |
2017 Medical College of Wisconsin; Advancing a Healthier Wisconsin Endowment, Conversations with Scientists: Chronic Pain & Addiction |
COMMUNITY SERVICE ACTIVITIES: |
2016 - Present Opioid/Heroin Overdose Prevention Academic Workgroup |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Olsen CM, Lovering AT, Carr JA. alpha-melanocyte-stimulating hormone and habituation of prey-catching behavior in the Texas toad, Bufo speciosus. Horm Behav. 1999 Aug;36(1):62-9. |
2. Olsen CM, Duvauchelle CL. Intra-prefrontal cortex injections of SCH 23390 influence nucleus accumbens dopamine levels 24 h post-infusion. Brain Res. 2001 Dec 13;922(1):80-6. |
3. Ikegami A, Olsen CM, Fleming SM, Guerra EE, Bittner MA, Wagner J, Duvauchelle CL. Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone. Pharmacol Biochem Behav. 2002 Jul;72(4):787-94. |
4. Berlanga ML, Olsen CM, Chen V, Ikegami A, Herring BE, Duvauchelle CL, Alcantara AA. Cholinergic interneurons of the nucleus accumbens and dorsal striatum are activated by the self-administration of cocaine. Neuroscience. 2003;120(4):1149-56. |
5. D'Souza MS, Ikegami A, Olsen CM, Duvauchelle CL. Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors. Pharmacol Biochem Behav. 2003 Sep;76(2):335-42. |
6. Jones DC, Duvauchelle C, Ikegami A, Olsen CM, Lau SS, de la Torre R, Monks TJ. Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. J Pharmacol Exp Ther. 2005 Apr;313(1):422-31. |
7. Schramm-Sapyta NL, Olsen CM, Winder DG. Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology. 2006 Jul;31(7):1444-51. |
8. Olsen CM, Duvauchelle CL. Prefrontal cortex D1 modulation of the reinforcing properties of cocaine. Brain Res. 2006 Feb 23;1075(1):229-35. |
9. Grueter BA, Gosnell HB, Olsen CM, Schramm-Sapyta NL, Nekrasova T, Landreth GE, Winder DG. Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. J Neurosci. 2006 Mar 22;26(12):3210-9. PMCID: PMC6674094 |
10. Olsen CM, Winder DG. A method for single-session cocaine self-administration in the mouse. Psychopharmacology (Berl). 2006 Jul;187(1):13-21. |
11. Ikegami A, Olsen CM, D'Souza MS, Duvauchelle CL. Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses. Behav Neurosci. 2007 Apr;121(2):389-400. PMCID: PMC2565684 |
12. Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG. Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. Physiol Genomics. 2008 Feb 19;32(3):283-98. |
13. Olsen CM, Winder DG. Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. Neuropsychopharmacology. 2009 Jun;34(7):1685-94. PMCID: PMC2720253 |
14. Olsen CM, Winder DG. Operant sensation seeking in the mouse. J Vis Exp. 2010 Nov 10(45). PMCID: PMC3159589 |
15. Olsen CM, Childs DS, Stanwood GD, Winder DG. Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). PLoS One. 2010 Nov 30;5(11):e15085. PMCID: PMC2994905 |
16. Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA. (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem Neurosci. 2011 Aug 17;2(8):471-482. PMCID: PMC3172161 |
17. Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW. Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. ChemMedChem. 2012 Mar 05;7(3):406-14. PMCID: PMC3517057 |
18. Olsen CM, Winder DG. Stimulus dynamics increase the self-administration of compound visual and auditory stimuli. Neurosci Lett. 2012 Mar 05;511(1):8-11. PMCID: PMC3299404 |
19. Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology. 2014 Mar;39(4):989-99. PMCID: PMC3924533 |
20. Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD. Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. Ann Biomed Eng. 2015 May;43(5):1071-88. PMCID: PMC4654450 |
21. Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH. S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. J Neurosci. 2015 Feb 04;35(5):1892-904. PMCID: PMC4315826 |
22. Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ. Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. J Neurosci. 2015 May 13;35(19):7503-8. PMCID: PMC4429154 |
23. Lim YW, Meyer NP, Shah AS, Budde MD, Stemper BD, Olsen CM. Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury. PLoS One. 2015;10(4):e0125130. PMCID: PMC4409117 |
24. Stemper B.D., Shah A.S., Budde M.D., Chiariello R., Wilkins N., Olsen C., Mehta P., Kurpad S.N., McCrea M., Pintar F.A. . Characterization of differing time-course of cognitive deficits and emotional changes following rotational traumatic brain injury in the rat 2015 IRCOBI Conference Proceedings. 198-207. |
25. Stemper BD, Shah AS, Budde MD, Olsen CM, Glavaski-Joksimovic A, Kurpad SN, McCrea M, Pintar FA. Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury. Front Neurol. 2016;7:31. PMCID: PMC4789366 |
26. Stemper BD, Shah AS, Chiariello R, Olsen CM, Budde MD, Glavaski-Joksimovic A, McCrea M, Kurpad SN, Pintar FA. Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics. Ann Biomed Eng. 2016 Nov;44(11):3252-3265. PMCID: PMC5093216 |
27. Muelbl MJ, Nawarawong NN, Clancy PT, Nettesheim CE, Lim YW, Olsen CM. Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice. Psychopharmacology (Berl). 2016 Jul;233(14):2799-811. PMCID: PMC5095929 |
28. Helfand AI, Olsen CM, Hillard CJ. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. Int J Mol Sci. 2017 Jul 27;18(8). PMCID: PMC5578025 |
29. Nelson LD, Furger RE, Ranson J, Tarima S, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, Olsen CM, Lerner EB, McCrea MA. Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumatic Brain Injuries. J Neurotrauma. 2018 Jan 15;35(2):249-259. PMCID: PMC5784791 |
30. Muelbl MJ, Slaker ML, Shah AS, Nawarawong NN, Gerndt CH, Budde MD, Stemper BD, Olsen CM. Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors. Sci Rep. 2018 Jul 02;8(1):9941. PMCID: PMC6028456 |
31. Nawarawong NN, Slaker M, Muelbl M, Shah AS, Chiariello R, Nelson LD, Budde MD, Stemper BD, Olsen CM. Repeated blast model of mild traumatic brain injury alters oxycodone self-administration and drug seeking. Eur J Neurosci. 2019 Aug;50(3):2101-2112. PMCID: PMC6814147 |
32. Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. iScience. 2018 May 25;3:192-207. PMCID: PMC6137433 |
33. Nawarawong NN, Olsen CM. Within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortex. Behav Brain Res. 2020 Feb 03;379:112275. PMCID: PMC7937550 |
34. Jessen K, Slaker Bennett ML, Liu S, Olsen CM. Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key. J Neurosci Res. 2022 Apr;100(4):1008-1029. PMCID: PMC8940716 |
35. Raber J, Holden S, Sudhakar R, Hall R, Glaeser B, Lenarczyk M, Rockwell K, Nawarawong N, Sterrett J, Perez R, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen CM, Willey JS, Bobe G, Baker J. Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats. Front Physiol. 2021;12:746509. PMCID: PMC8503608 |
36. Olsen CM, Corrigan JD. Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder? Biol Psychiatry. 2022 Mar 01;91(5):421-437. PMCID: PMC8776913 |
37. Raff H, Glaeser BL, Szabo A, Olsen CM, Everson CA. Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats. Stress. 2023 Jan;26(1):2185864. PMCID: PMC10339708 |
38. Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM. Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats. Behav Brain Res. 2023 Feb 13;438:114181. PMCID: PMC9993345 |
39. Olsen CM, Herrold AA, Conti AC, Vonder Haar C. Editorial: Behavioral outcomes of traumatic brain injury. Front Behav Neurosci. 2022;16:1010395. PMCID: PMC9490366 |
40. Stemper BD, Shah A, Chiariello R, McCarthy C, Jessen K, Sarka B, Seifert J, Budde MD, Wang K, Olsen CM, McCrea M. A Preclinical Rodent Model for Repetitive Subconcussive Head Impact Exposure in Contact Sport Athletes. Front Behav Neurosci. 2022;16:805124. PMCID: PMC8965565 |
41. Muelbl MJ, Glaeser BL, Shah AS, Chiariello RA, Nawarawong NN, Stemper BD, Budde MD, Olsen CM. Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes. Addict Biol. 2022 Mar;27(2):e13134. PMCID: PMC8896287 |
42. Liu S, Nawarawong N, Liu X, Liu QS, Olsen CM. Dissociable dorsal medial prefrontal cortex ensembles are necessary for cocaine seeking and fear conditioning in mice. Transl Psychiatry. 2024 Sep 23;14(1):387. PMCID: PMC11420216 |
43. Sarka BC, Liu S, Banerjee A, Stucky CL, Liu QS, Olsen CM. Neuropathic pain has sex-specific effects on oxycodone-seeking and non-drug-seeking ensemble neurons in the dorsomedial prefrontal cortex of mice. Addict Biol. 2024 Aug;29(8):e13430. PMCID: PMC11315577 |
44. Liu S, Nawarawong N, Liu X, Liu QS, Olsen CM. Dissociable dorsal medial prefrontal cortex ensembles are necessary for cocaine seeking and fear conditioning in mice. bioRxiv. 2024 Mar 18. PMCID: PMC10983871 |
45. Glaeser B, Panariello V, Banerjee A, Olsen CM. Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons. Drug Alcohol Depend. 2024 Feb 01;255:111077. PMCID: PMC10869844 |
46. Olsen CM, Glaeser BL, Szabo A, Raff H, Everson CA. The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis-related phenotypes. Physiol Behav. 2023 Dec 01;272:114372. PMCID: PMC10841994 |
Books, Chapters, and Reviews |
1. Olsen CM. Natural rewards, neuroplasticity, and non-drug addictions. Neuropharmacology. 2011 Dec;61(7):1109-22. PMCID: PMC3139704 |
2. CM Olsen and QS Liu Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities. Frontiers in Biology. 2016. 11:376-86. |
