CURRICULUM VITAE
Chun Liu PhD
Chun Liu PhD
Assistant Professor
Department of Physiology
Department of Physiology
OFFICE ADDRESS: |
Froedtert Hospital |
9200 W Wisconsin Ave |
Milwaukee, WI 53226 |
Email: chunliu@mcw.edu |
EDUCATION: |
09/01/2003 - 07/31/2007 BS, China Agricultural University, Beijing, China |
09/01/2007 - 01/01/2014 PhD, Peking University, Beijing, China |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
05/01/2015 - 07/01/2019 Postdoctoral Fellow, Stanford Cardiovascular Institute, Stanford Unversity |
01/07/2024 - Present Mentor Research Training, Center for the Improvement of Mentored Experiences in Research, MCW, Milwaukee, WI |
FACULTY APPOINTMENTS: |
07/01/2019 - 06/30/2023 Instructor, Stanford Cardiovascular Institute, Stanford University |
07/31/2023 - Present Assistant Professor, Physiology and Medicine, Cardiovascular and Cancer Center, Medical College of Wisconsin |
AWARDS AND HONORS: |
2013 Innovation Prize, Peking University |
2016 - 2018 Western States Postdoctoral Fellowship Award, American Heart Association |
2019 - 2022 Career Development Award, American Heart Association |
2021 American Heart Association Scientific Session Travel Award, American Heart Association |
2021 Stanford Cardiovascular Institute Travel Award, Stanford Cardiovascular Institute |
2022 Stanford-Cornell Cardiovascular Research Symposium Poster Award, Stanford Cardiovascular Institute |
2023 - 2026 Second Century Early Faculty Independence Award, American Heart Association |
01/01/2024 - 12/31/2024 MCW Cancer Center BTCP Idea Award Pilot Grant, MCW Cancer Center |
2024 - Present Basic Cardiovascular Sciences Outstanding Early Career Investigator Award Finalist , American Heart Association |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2015 - Present American Heart Association (member) |
2021 - Present International Society for Stem Cell Research (ISSCR) (member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
Frontiers in Cell and Developmental Biology |
Frontiers in Cardiovascular Medicine |
Journal Review |
Journal of Tissue Engineering and Regenerative Medicine |
Cellular Physiology and Biochemistry |
PLoS One |
Scientific Report |
Circulation Research |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Chun Liu, Modeling cardiovascular dysfunction in lamin A/C mutation associated cardiomyopathy, Global Talents in Science 2021 Symposium, Birmingham, AL, US, 2021 - Present |
Chun Liu, iPSC Models Uncovering Statin's Epigenetic Role in Vascular Health Protection, 12th World Congress of Microcirculation, Beijing, China, 09/20/2023 - 09/24/2023 |
Chun Liu, Druggable Genome CRISPR Screens in iPSC-Derived Cardiomyocytes Identify Therapeutic Targets for Doxorubicin-Induced Cardiotoxicity, AHA Basic Cardiovascular Sciences Scientific Sessions, Chicago, IL, 07/22/2024 - 07/25/2024 |
Chun Liu, Druggable Genome CRISPR Screens in iPSC-Derived Cardiomyocytes Identify Therapeutic Targets for Doxorubicin-Induced Cardiotoxicity, Global CardioOncology Summit 2024, Minneapolis, MN, 09/22/2024 - 09/24/2024 |
Regional |
Chun Liu, Grow your heart in a dish, THE WISCONSIN SCIENCE EDUCATION AND RESEARCH CONSORTIUM Annual Conference, Milwaukee, WI, 10/05/2024 - 10/07/2024 |
Local |
Chun Liu, Stanford CVI and Basic Science & Engineering (BASE) Initiative Seminar, Stanford CVI and Basic Science & Engineering (BASE) Initiative Seminar, Stanford University, 2020 - Present |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Career Development Forum: Negotiating a First Faculty Position, North American Vascular Biology Organization, Online, 01/23/2024 - Present |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
11/16/2023 - Present Current Concepts in Cardiovascular Biology course (PHYS 08270) |
03/15/2024 - 03/20/2024 Functional Genomics (Cellular Reprogramming and CRISPR screen) |
COMMUNITY SERVICE ACTIVITIES: |
09/17/2024 The 5th MCW Annual Postdoc Research Symposium Poster Judge |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008 Nov 06;3(5):475-9. |
2. Zhao D, Chen S, Cai J, Guo Y, Song Z, Che J, Liu C, Wu C, Ding M, Deng H. Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS One. 2009 Jul 31;4(7):e6468. PMCID: PMC2714184 |
3. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 2011 Jan;21(1):196-204. PMCID: PMC3193405 |
4. Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 09;341(6146):651-4. |
5. Sayed N, Liu C, Wu JC. Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine. J Am Coll Cardiol. 2016 May 10;67(18):2161-2176. PMCID: PMC5086255 |
6. Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 2016 Sep 01;19(3):311-25. PMCID: PMC5087997 |
7. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017 Aug 22;20(8):1978-1990. PMCID: PMC5573767 |
8. Liu C, Himmati F, Sayed N. Paying the Toll in Nuclear Reprogramming. Front Cell Dev Biol. 2017;5:70. PMCID: PMC5562677 |
9. Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11111-E11120. PMCID: PMC5748177 |
10. Liu C, Oikonomopoulos A, Sayed N, Wu JC. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. Development. 2018 Mar 08;145(5). PMCID: PMC5868991 |
11. Khanamiri S, Rhee JW, Paik DT, Chen IY, Liu C, Sayed N. Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy. J Vasc Res. 2019;56(1):11-15. PMCID: PMC6500747 |
12. Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell. 2019 May 02;24(5):802-811.e5. PMCID: PMC6499654 |
13. Yang H, Qin X, Wang H, Zhao X, Liu Y, Wo HT, Liu C, Nishiga M, Chen H, Ge J, Sayed N, Abilez OJ, Ding D, Heilshorn SC, Li K. An <i>in Vivo</i> miRNA Delivery System for Restoring Infarcted Myocardium. ACS Nano. 2019 Sep 24;13(9):9880-9894. PMCID: PMC7930012 |
14. Wnorowski A, Sharma A, Chen H, Wu H, Shao NY, Sayed N, Liu C, Countryman S, Stodieck LS, Rubins KH, Wu SM, Lee PHU, Wu JC. Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. Stem Cell Reports. 2019 Dec 10;13(6):960-969. PMCID: PMC6915842 |
15. Liu C, Ruan H, Himmati F, Zhao MT, Chen CC, Makar M, Chen IY, Sallam K, Mocarski ES, Sayed D, Sayed N. HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming. Stem Cell Reports. 2020 Feb 11;14(2):192-200. PMCID: PMC7013248 |
16. Kitani T, Tian L, Zhang T, Itzhaki I, Zhang JZ, Ma N, Liu C, Rhee JW, Romfh AW, Lui GK, Wu JC. RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Congenital Heart Disease Patients. Circ Res. 2020 Mar 27;126(7):923-925. PMCID: PMC7123776 |
17. Tian L, Oikonomopoulos A, Liu C, Kitani T, Shrestha R, Chen CL, Ong SG, Smeets M, Karakikes I, Sayed N, Wu JC. Molecular Signatures of Beneficial Class Effects of Statins on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. 2020 Apr 07;141(14):1208-1210. PMCID: PMC7170011 |
18. Wang Y, Han D, Zhou T, Zhang J, Liu C, Cao F, Dong N. Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. J Pineal Res. 2020 Sep;69(2):e12666. |
19. Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Sci Transl Med. 2020 Jul 29;12(554). PMCID: PMC7557117 |
20. Paik DT, Tian L, Williams IM, Rhee S, Zhang H, Liu C, Mishra R, Wu SM, Red-Horse K, Wu JC. Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells. Circulation. 2020 Nov 10;142(19):1848-1862. PMCID: PMC7658053 |
21. Chandy M, Rhee JW, Ozen MO, Williams DR, Pepic L, Liu C, Zhang H, Malisa J, Lau E, Demirci U, Wu JC. Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types. Circulation. 2020 Nov 03;142(18):1794-1796. PMCID: PMC8135104 |
22. Liu C, Ameen M, Himmati S, Thomas D, Sayed N. Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling. Methods Mol Biol. 2021;2239:153-162. |
23. Ouyang X, Liu Y, Zhou Y, Guo J, Wei TT, Liu C, Lee B, Chen B, Zhang A, Casey KM, Wang L, Kooreman NG, Habtezion A, Engleman EG, Wu JC. Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer. Stem Cell Reports. 2021 Jun 08;16(6):1468-1477. PMCID: PMC8190592 |
24. Liu C, Medina P, Thomas D, Chen IY, Sallam K, Sayed D, Sayed N. A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity. STAR Protoc. 2021 Jun 18;2(2):100556. PMCID: PMC8190482 |
25. Wang Y, Han D, Zhou T, Chen C, Cao H, Zhang JZ, Ma N, Liu C, Song M, Shi J, Jin X, Cao F, Dong N. DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells. Eur Heart J. 2021 Aug 07;42(30):2935-2951. |
26. Tran MV, Marceau E, Liu Y, Sallam K, Medina P, Liu C, Sayed N, Muller MD, Liang DH, Chen IY. Coronary Artery Vasospasm Requiring Cardiac Autotransplantation Yet Controlled With Tobacco. JACC Case Rep. 2021 Aug 04;3(9):1177-1181. PMCID: PMC8353556 |
27. Zhang M, Qian L, Liu C, Huang GN, Tao G. Editorial: Cardiomyocyte Maturation: Novel Insights for Regenerative Medicine. Front Cell Dev Biol. 2021;9:730622. PMCID: PMC8365607 |
28. Nishiga M, Liu C, Qi LS, Wu JC. The use of new CRISPR tools in cardiovascular research and medicine. Nat Rev Cardiol. 2022 Aug;19(8):505-521. PMCID: PMC10283450 |
29. Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022 May 12;185(10):1676-1693.e23. PMCID: PMC9400797 |
30. Shen M, Liu C, Wu JC. Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells. Methods Mol Biol. 2022;2429:233-246. PMCID: PMC9667909 |
31. Wang J, Soto F, Ma P, Ahmed R, Yang H, Chen S, Wang J, Liu C, Akin D, Fu K, Cao X, Chen P, Hsu EC, Soh HT, Stoyanova T, Wu JC, Demirci U. Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots. ACS Nano. 2022 Jul 26;16(7):10219-10230. |
32. Yang Y, Liu A, Tsai CT, Liu C, Wu JC, Cui B. Cardiotoxicity drug screening based on whole-panel intracellular recording. Biosens Bioelectron. 2022 Nov 15;216:114617. PMCID: PMC9930661 |
33. Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2023 Jan 20;132(2):187-204. PMCID: PMC9852089 |
34. Shen M, Liu C, Zhao SR, Manhas A, Sundaram L, Ameen M, Wu JC. Stepwise Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pericytes to Model Coronary Microvascular Dysfunction. Circulation. 2023 Feb 07;147(6):515-518. PMCID: PMC9909621 |
35. Shen M, Zhao SR, Khokhar Y, Li L, Zhou Y, Liu C, Wu JC. Protocol to generate cardiac pericytes from human induced pluripotent stem cells. STAR Protoc. 2023 Apr 27;4(2):102256. PMCID: PMC10173856 |
36. Chun Liu, Mengcheng Shen, Wilson L. W. Tan, Ian Y. Chen, Yu Liu, Xuan Yu, Huaxiao Yang, Angela Zhang, Yanxia Liu, Ming-Tao Zhao, Mohamed Ameen, Mao Zhang, Eric R. Gross, Lei S. Qi, Nazish Sayed & Joseph C. Wu. Statins improve endothelial function via suppression of epigenetic-driven EndMT Nature Cardiovascular Research. (2023). https://doi.org/10.1038/s44161-023-00267-1. |
37. Colville A, Liu JY, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee JW, Lai C, Wu JC, Bassik MC, Rando TA. Death-seq identifies regulators of cell death and senolytic therapies. Cell Metab. 2023 Oct 03;35(10):1814-1829.e6. PMCID: PMC10597643 |
