Faculty Collaboration Database

1. Sigmund CD, Morgan EA. Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A. 1982 Sep;79(18):5602-6. PMCID: PMC346952

2. Mark LG, Sigmund CD, Morgan EA. Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. J Bacteriol. 1983 Sep;155(3):989-94. PMCID: PMC217790

3. Sigmund CD, Ettayebi M, Morgan EA. Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res. 1984 Jun 11;12(11):4653-63. PMCID: PMC318865

4. Sigmund CD, Ettayebi M, Borden A, Morgan EA. Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol. 1988;164:673-90.

5. Mullins JJ, Sigmund CD, Kane-Haas C, Wu CZ, Pacholec F, Zeng Q, Gross KW. Studies on the regulation of renin genes using transgenic mice. Clin Exp Hypertens A. 1988;10(6):1157-67.

6. Sigmund CD, Morgan EA. Effects of Escherichia coli Nus A protein on transcription termination in vitro are not increased or decreased by DNA sequences sufficient for antitermination in vivo. Biochemistry. 1988 Jul 26;27(15):5628-35.

7. Sigmund CD, Morgan EA. Nus A protein affects transcriptional pausing and termination in vitro by binding to different sites on the transcription complex. Biochemistry. 1988 Jul 26;27(15):5622-7.

8. Fabian JR, Field LJ, McGowan RA, Mullins JJ, Sigmund CD, Gross KW. Allele-specific expression of the murine Ren-1 genes. J Biol Chem. 1989 Oct 15;264(29):17589-94.

9. Mullins JJ, Sigmund CD, Kane-Haas C, Gross KW, McGowan RA. Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. EMBO J. 1989 Dec 20;8(13):4065-72. PMCID: PMC401583

10. Jones CA, Sigmund CD, McGowan RA, Kane-Haas CM, Gross KW. Expression of murine renin genes during fetal development. Mol Endocrinol. 1990 Mar;4(3):375-83.

11. Sigmund CD, Jones CA, Fabian JR, Mullins JJ, Gross KW. Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice. Biochem Biophys Res Commun. 1990 Jul 16;170(1):344-50.

12. Sigmund CD, Jones CA, Mullins JJ, Kim U, Gross KW. Expression of murine renin genes in subcutaneous connective tissue. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7993-7. PMCID: PMC54878

13. Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu CZ, Kenny L, Rustum Y. Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem. 1990 Nov 15;265(32):19916-22.

14. Sigmund CD, Gross KW. Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue. Biochem Biophys Res Commun. 1990 Nov 30;173(1):218-23.

15. Sigmund CD, Jones CA, Jacob HJ, Ingelfinger J, Kim U, Gamble D, Dzau VJ, Gross KW. Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. Am J Physiol. 1991 Feb;260(2 Pt 2):F249-57.

16. Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ. Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension. 1991 Jun;17(6 Pt 2):1167-62.

17. Sigmund CD, Gross KW. Structure, expression, and regulation of the murine renin genes. Hypertension. 1991 Oct;18(4):446-57.

18. Lim SK, Sigmund CD, Gross KW, Maquat LE. Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol. 1992 Mar;12(3):1149-61. PMCID: PMC369546

19. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW. Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ Res. 1992 May;70(5):1070-9.

20. Sigmund CD, Fabian JR, Gross KW. Expression and regulation of the renin gene. Trends Cardiovasc Med. 1992;2(6):237-45.

21. Sigmund CD. Major approaches for generating and analyzing transgenic mice. An overview. Hypertension. 1993 Oct;22(4):599-607.

22. Sigmund CD. Expression of the human renin gene in transgenic mice throughout ontogeny. Pediatr Nephrol. 1993 Oct;7(5):639-45.

23. Lang JA, Sinclair NL, Burson JM, Sigmund CD. Transgenic animals as tools in hypertension research. Proc Soc Exp Biol Med. 1994 Feb;205(2):106-18.

24. Burson JM, Aguilera G, Gross KW, Sigmund CD. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol. 1994 Aug;267(2 Pt 1):E260-7.

25. Held WA, O'Brien JG, Kerns K, Gallagher JF, Sigmund CD, Gross KW. Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. Cancer Res. 1994 Dec 15;54(24):6496-9.

26. Yang G, Merrill DC, Thompson MW, Robillard JE, Sigmund CD. Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem. 1994 Dec 23;269(51):32497-502.

27. Smith DL, Jeyapalan S, Lang JA, Guo XH, Sigmund CD, Morris BJ. Human renin 5'-flanking DNA to nucleotide-2750. DNA Seq. 1995;5(5):319-21.

28. Lang JA, Yang G, Kern JA, Sigmund CD. Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension. 1995 Apr;25(4 Pt 2):704-10.

29. Thompson HA, Burson JM, Lang JA, Gross KW, Sigmund CD. Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45.

30. Thompson MW, Merrill DC, Yang G, Robillard JE, Sigmund CD. Transgenic animals in the study of blood pressure regulation and hypertension. Am J Physiol. 1995 Nov;269(5 Pt 1):E793-803.

31. Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest. 1996 Feb 15;97(4):1047-55. PMCID: PMC507152

32. Lang JA, Ying LH, Morris BJ, Sigmund CD. Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. Am J Physiol. 1996 Jul;271(1 Pt 2):F94-100.

33. Thompson MW, Smith SB, Sigmund CD. Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension. 1996 Aug;28(2):290-6.

34. Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem. 1996 Sep 13;271(37):22499-505.

35. Davisson RL, Nuutinen N, Coleman ST, Sigmund CD. Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res. 1996 Oct 15;24(20):4023-8. PMCID: PMC146210

36. Davisson RL, Sigmund CD. Transgenic animal models as tools for studying renal developmental physiology. Pediatr Nephrol. 1996 Dec;10(6):798-803.

37. Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, Gross KW. Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem. 1997 Jan 15;243(1-2):181-90.

38. Ying L, Morris BJ, Sigmund CD. Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem. 1997 Jan 24;272(4):2412-20.

39. Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD. Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest. 1997 Mar 15;99(6):1258-64. PMCID: PMC507940

40. Petrovic N, Kane CM, Sigmund CD, Gross KW. Downregulation of renin gene expression by interleukin-1. Hypertension. 1997 Aug;30(2 Pt 1):230-5.

41. Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res. 1997 Oct;81(4):558-66.

42. Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem. 1997 Oct 31;272(44):28142-8.

43. Merrill DC, Granwehr BP, Davis DR, Sigmund CD. Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. Proc Assoc Am Physicians. 1997 Nov;109(6):533-46.

44. Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol. 1998 Feb;274(2):H564-70.

45. Yang G, Sigmund CD. Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension. 1998 Mar;31(3):734-40.

46. Yang G, Sigmund CD. Developmental expression of human angiotensinogen in transgenic mice. Am J Physiol. 1998 May;274(5):F932-9.

47. Stec DE, Sigmund CD. Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Exp Nephrol. 1998;6(6):568-75.

48. Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD. The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res. 1998 Nov 16;83(10):1047-58.

49. Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF. Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circ Res. 1998 Dec 14-28;83(12):1279-88.

50. Yang G, Gray TS, Sigmund CD, Cassell MD. The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res. 1999 Jan 30;817(1-2):123-31.

51. Sinn PL, Sigmund CD. Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension. 1999 Mar;33(3):900-5.

52. Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD. Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem. 1999 Jul 23;274(30):21285-90.

53. Lake-Bruse KD, Faraci FM, Shesely EG, Maeda N, Sigmund CD, Heistad DD. Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol. 1999 Aug;277(2):H770-6.

54. Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res. 1999 Sep 17;85(6):479-88.

55. Sinn PL, Zhang X, Sigmund CD. JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol. 1999 Oct;277(4):F634-42.

56. Sinn PL, Davis DR, Sigmund CD. Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. J Biol Chem. 1999 Dec 10;274(50):35785-93.

57. Faraci FM, Sigmund CD. Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circ Res. 1999 Dec 3-17;85(12):1214-25.

58. Cvetkovic B, Yang B, Williamson RA, Sigmund CD. Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem. 2000 Jan 14;275(2):1073-8.

59. Sinn PL, Sigmund CD. Transgenic models as tools for studying the regulation of human renin expression. Regul Pept. 2000 Jan 29;86(1-3):77-82.

60. Didion SP, Sigmund CD, Faraci FM. Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Stroke. 2000 Mar;31(3):760-4; discussion 765.

61. Wang Q, Sigmund CD, Lin JJ. Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res. 2000 Mar 03;86(4):478-84.

62. Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD, Haynes WG. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens. 1999 Dec;17(12 Pt 2):1949-53.

63. Cvetkovic B, Sigmund CD. Understanding hypertension through genetic manipulation in mice. Kidney Int. 2000 Mar;57(3):863-74.

64. Sigmund CD. Viewpoint: are studies in genetically altered mice out of control? Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1425-9.

65. Davisson RL, Oliverio MI, Coffman TM, Sigmund CD. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest. 2000 Jul;106(1):103-6. PMCID: PMC314366

66. Lake-Bruse KD, Sigmund CD. Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Curr Hypertens Rep. 2000 Apr;2(2):211-6.

67. Sinn PL, Sigmund CD. Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics. 2000 Jun 29;3(1):25-31.

68. Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics. 1999 Jul 15;1(1):3-9.

69. Khan AH, Thurmond DC, Yang C, Ceresa BP, Sigmund CD, Pessin JE. Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem. 2001 Feb 09;276(6):4063-9. PMCID: PMC5540311

70. Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem. 2001 Feb 02;276(5):3597-603.

71. Ding Y, Stec DE, Sigmund CD. Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. J Biol Chem. 2001 Mar 09;276(10):7431-6.

72. Sigmund CD, Stec DE. Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase. Methods Mol Med. 2001;51:53-65.

73. Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol. 2001 Jan;280(1):F54-60.

74. Keen HL, Sigmund CD. Paradoxical regulation of short promoter human renin transgene by angiotensin ii. Hypertension. 2001 Feb;37(2 Pt 2):403-7.

75. Stec DE, Sigmund CD. Physiological insights from genetic manipulation of the renin-angiotensin system. News Physiol Sci. 2001 Apr;16:80-4.

76. Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, Sigmund CD, Heistad DD, Faraci FM, Lentz SR. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res. 2001 Jun 08;88(11):1203-9.

77. Sigmund CD. Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney. Am J Hypertens. 2001 Jun;14(6 Pt 2):33S-37S.

78. Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD. Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res. 2001 Aug 17;89(4):365-72.

79. Stec DE, Morimoto S, Sigmund CD. Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Biotechniques. 2001 Aug;31(2):256-8, 260.

80. Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem. 2001 Dec 07;276(49):45530-8.

81. Shi Q, Gross KW, Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension. 2001 Sep;38(3):332-6.

82. Sigmund CD. Genetic manipulation of the renin-angiotensin system in the kidney. Acta Physiol Scand. 2001 Sep;173(1):67-73.

83. Wilson K, Fry GL, Chappell DA, Sigmund CD, Medh JD. Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1809-15. PMCID: PMC2768479

84. Myung PS, Derimanov GS, Jordan MS, Punt JA, Liu QH, Judd BA, Meyers EE, Sigmund CD, Freedman BD, Koretzky GA. Differential requirement for SLP-76 domains in T cell development and function. Immunity. 2001 Dec;15(6):1011-26.

85. Morimoto S, Cassell MD, Sigmund CD. The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res. 2002 Jan 11;90(1):80-6.

86. Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD. Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):42-8.

87. Stec DE, Keen HL, Sigmund CD. Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. Hypertension. 2002 Feb;39(2 Pt 2):629-33.

88. Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD, Davisson RL. Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res. 2002 Mar 22;90(5):617-24.

89. Nistala R, Sigmund CD. A reliable and efficient method for deleting operational sequences in PACs and BACs. Nucleic Acids Res. 2002 May 15;30(10):e41. PMCID: PMC115295

90. Morimoto S, Cassell MD, Sigmund CD. Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. Physiol Genomics. 2002;9(2):113-20.

91. Glueck SB, Sigmund CD. Meeting report: Physiological Genomics of Cardiovascular Disease: from Technology to Physiology. Physiol Genomics. 2002;9(3):135-6.

92. Morimoto S, Cassell MD, Sigmund CD. Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J Biol Chem. 2002 Sep 06;277(36):33235-41.

93. Sigmund CD. Regulation of renin expression and blood pressure by vitamin D(3). J Clin Invest. 2002 Jul;110(2):155-6. PMCID: PMC151071

94. Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1569-76.

95. Morimoto S, Sigmund CD. Angiotensin mutant mice: a focus on the brain renin-angiotensin system. Neuropeptides. 2002;36(2-3):194-200.

96. Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD. Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. Physiol Genomics. 2002 Dec 03;11(3):253-62.

97. Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002 Nov 15;91(10):938-44.

98. Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR. Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res. 2002 Nov 15;91(10):931-7.

99. Baumbach GL, Sigmund CD, Faraci FM. Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension. 2003 Jan;41(1):50-5.

100. Tran ND, Liu X, Yan Z, Abbote D, Jiang Q, Kmiec EB, Sigmund CD, Engelhardt JF. Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Mol Ther. 2003 Feb;7(2):248-53.

101. Liu X, Huang X, Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res. 2003 May 16;92(9):1033-40.

102. Bianco RA, Keen HL, Lavoie JL, Sigmund CD. Untraditional methods for targeting the kidney in transgenic mice. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1027-33.

103. Ryan MJ, Sigmund CD. HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression. Arterioscler Thromb Vasc Biol. 2003 Nov 01;23(11):1960-2.

104. Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol Genomics. 2004 Jan 15;16(2):240-6.

105. Chen CC, Lamping KG, Nuno DW, Barresi R, Prouty SJ, Lavoie JL, Cribbs LL, England SK, Sigmund CD, Weiss RM, Williamson RA, Hill JA, Campbell KP. Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science. 2003 Nov 21;302(5649):1416-8.

106. Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW. Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension. 2004 Feb;43(2):312-6.

107. Nistala R, Zhang X, Sigmund CD. Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiol Genomics. 2004 Mar 12;17(1):4-10.

108. Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension. 2004 Mar;43(3):661-6.

109. Rahmouni K, Mark AL, Haynes WG, Sigmund CD. Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E891-5.

110. Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A. 2004 Mar 09;101(10):3621-6. PMCID: PMC373512

111. Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension. 2004 May;43(5):1074-9.

112. Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension. 2004 May;43(5):1116-9.

113. Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD. Gene expression profiling of potential PPARgamma target genes in mouse aorta. Physiol Genomics. 2004 Jun 17;18(1):33-42.

114. Lavoie JL, Lake-Bruse KD, Sigmund CD. Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am J Physiol Renal Physiol. 2004 May;286(5):F965-71.

115. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 2004 May 11;109(18):2221-6.

116. Dayal S, Arning E, Bottiglieri T, Böger RH, Sigmund CD, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke. 2004 Aug;35(8):1957-62.

117. Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L752-63.

118. Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF. Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. J Invest Dermatol. 2004 Aug;123(2):264-74. PMCID: PMC1803077

119. Lavoie JL, Bianco RA, Sakai K, Keen HL, Ryan MJ, Sigmund CD. Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta Physiol Scand. 2004 Aug;181(4):571-7.

120. Stunz LL, Busch LK, Munroe ME, Sigmund CD, Tygrett LT, Waldschmidt TJ, Bishop GA. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity. 2004 Aug;21(2):255-66.

121. Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest. 2004 Sep;114(5):652-8. PMCID: PMC514588

122. Sherrod M, Liu X, Zhang X, Sigmund CD. Nuclear localization of angiotensinogen in astrocytes. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R539-46.

123. Baumbach GL, Sigmund CD, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circ Res. 2004 Oct 15;95(8):822-9.

124. Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD. Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. Physiol Genomics. 2004 Dec 15;20(1):66-72.

125. Sakai K, Sigmund CD. Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. Curr Hypertens Rep. 2005 Apr;7(2):135-40. PMCID: PMC7088661

126. Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC. Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Hum Mol Genet. 2005 May 01;14(9):1109-18.

127. Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD. Spontaneous stroke in a genetic model of hypertension in mice. Stroke. 2005 Jun;36(6):1253-8.

128. Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP. Cerebral vascular effects of angiotensin II: new insights from genetic models. J Cereb Blood Flow Metab. 2006 Apr;26(4):449-55.

129. Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1763-9.

130. Halabi CM, Sigmund CD. Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. Am J Cardiovasc Drugs. 2005;5(6):389-98.

131. Kiss PJ, Knisz J, Zhang Y, Baltrusaitis J, Sigmund CD, Thalmann R, Smith RJ, Verpy E, Bánfi B. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol. 2006 Jan 24;16(2):208-13.

132. Sethi S, Iida S, Sigmund CD, Heistad DD. Renal thrombotic microangiopathy in a genetic model of hypertension in mice. Exp Biol Med (Maywood). 2006 Feb;231(2):196-203.

133. Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD. Evidence supporting a functional role for intracellular renin in the brain. Hypertension. 2006 Mar;47(3):461-6.

134. Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int. 2006 Mar;69(6):1016-23.

135. Cao XR, Shi PP, Sigmund RD, Husted RF, Sigmund CD, Williamson RA, Stokes JB, Yang B. Mice heterozygous for beta-ENaC deletion have defective potassium excretion. Am J Physiol Renal Physiol. 2006 Jul;291(1):F107-15. PMCID: PMC2818793

136. Brand M, Lamandé N, Sigmund CD, Larger E, Corvol P, Gasc JM. Angiotensinogen modulates renal vasculature growth. Hypertension. 2006 Jun;47(6):1067-74.

137. Liu X, Shi Q, Sigmund CD. Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells. Endocrinology. 2006 Dec;147(12):6011-8.

138. Zhou X, Davis DR, Sigmund CD. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. J Biol Chem. 2006 Nov 17;281(46):35296-304.

139. Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL. Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circ Res. 2006 Nov 10;99(10):1125-31.

140. McCray PB Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007 Jan;81(2):813-21. PMCID: PMC1797474

141. Itani HA, Liu X, Pratt JH, Sigmund CD. Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology. 2007 Mar;148(3):1424-30.

142. Dickson ME, Zimmerman MB, Rahmouni K, Sigmund CD. The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. Hypertension. 2007 Mar;49(3):631-9.

143. Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 01;305(1):90-102. PMCID: PMC1892170

144. Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest. 2007 Apr;117(4):1088-95. PMCID: PMC1838949

145. Kobori H, Ozawa Y, Satou R, Katsurada A, Miyata K, Ohashi N, Hase N, Suzaki Y, Sigmund CD, Navar LG. Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol. 2007 Sep;293(3):F938-45. PMCID: PMC2000297

146. Zhou X, Sigmund CD. Chorionic enhancer is dispensable for regulated expression of the human renin gene. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R279-87. PMCID: PMC2408876

147. Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 2008 Apr;51(4):867-71. PMCID: PMC2408877

148. Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD. Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. J Cereb Blood Flow Metab. 2008 Jun;28(6):1175-85. PMCID: PMC3153951

149. Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 2008 Mar;7(3):215-26. PMCID: PMC2275166

150. Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1481-6. PMCID: PMC3584705

151. Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B. Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol. 2008 Aug;295(2):F462-70. PMCID: PMC2519178

152. de Lange WJ, Halabi CM, Beyer AM, Sigmund CD. Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiol Genomics. 2008 Sep 17;35(1):1-4. PMCID: PMC2574738

153. Zhou X, Weatherford ET, Liu X, Born E, Keen HL, Sigmund CD. Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. Am J Physiol Renal Physiol. 2008 Sep;295(3):F642-53. PMCID: PMC2536869

154. Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res. 2008 Sep 12;103(6):654-61. PMCID: PMC2583077

155. Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD. Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. Circ Res. 2008 Oct 24;103(9):940-7. PMCID: PMC2678906

156. Harlan SM, Reiter RS, Sigmund CD, Lin JL, Lin JJ. Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. Anat Rec (Hoboken). 2008 Dec;291(12):1574-86. PMCID: PMC2592506

157. Sigmund CD. A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1846-8. PMCID: PMC3597228

158. Rahmouni K, Sigmund CD, Haynes WG, Mark AL. Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes. 2009 Mar;58(3):536-42. PMCID: PMC2646051

159. Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1325-6. PMCID: PMC3597227

160. Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1914-9. PMCID: PMC2716103

161. Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD. Regulation of renin gene expression by oxidative stress. Hypertension. 2009 Jun;53(6):1070-6. PMCID: PMC2740736

162. Bianco RA, Agassandian K, Cassell MD, Spector AA, Sigmund CD. Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain Res. 2009 Sep 29;1291:60-72. PMCID: PMC2745107

163. Chen S, Li G, Zhang W, Wang J, Sigmund CD, Olson JE, Chen Y. Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1526-31. PMCID: PMC2777773

164. Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7. PMCID: PMC2783841

165. Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res. 2010 Feb 05;106(2):373-82. PMCID: PMC2818798

166. Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD. Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):518-25. PMCID: PMC2850258

167. Sigmund CD. Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 2010 Feb;55(2):437-44. PMCID: PMC2819308

168. Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA. The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol. 2010 Mar;21(3):460-7. PMCID: PMC2831866

169. Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. Hypertension. 2010 Mar;55(3):660-6. PMCID: PMC2907524

170. Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD. Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? J Biol Chem. 2010 Mar 26;285(13):9311-9316. PMCID: PMC2843178

171. Redding KM, Chen BL, Singh A, Re RN, Navar LG, Seth DM, Sigmund CD, Tang WW, Cook JL. Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1807-18. PMCID: PMC2886647

172. Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension. 2010 Nov;56(5):981-7. PMCID: PMC2959143

173. Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab. 2010 Nov 03;12(5):431-42. PMCID: PMC2994017

174. Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiol Genomics. 2011 Mar 29;43(6):286-94. PMCID: PMC3068515

175. Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension. 2011 Mar;57(3):600-7. PMCID: PMC3144490

176. Ostedgaard LS, Meyerholz DK, Vermeer DW, Karp PH, Schneider L, Sigmund CD, Welsh MJ. Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2921-6. PMCID: PMC3041073

177. Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K. Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res. 2011 Apr 01;108(7):808-12. PMCID: PMC3072835

178. Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1067-77. PMCID: PMC3197336

179. Sigmund CD. Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012 Feb 01;302(3):R313-20. PMCID: PMC3289263

180. He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med. 2011 Nov 13;17(12):1610-8. PMCID: PMC3332099

181. Weatherford ET, Liu X, Sigmund CD. Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F1025-33. PMCID: PMC3330716

182. Modrick ML, Kinzenbaw DA, Chu Y, Sigmund CD, Faraci FM. Peroxisome proliferator-activated receptor-γ protects against vascular aging. Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1184-90. PMCID: PMC3362146

183. Park S, Liu X, Davis DR, Sigmund CD. Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. Hypertension. 2012 Jun;59(6):1212-9. PMCID: PMC3357008

184. Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H197-206. PMCID: PMC3404702

185. Lin LH, Nitschke Dragon D, Jin J, Tian X, Chu Y, Sigmund C, Talman WT. Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat. J Physiol. 2012 Aug 01;590(15):3545-59. PMCID: PMC3547269

186. Cai J, Keen HL, Sigmund CD, Casavant TL. Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. J Integr Bioinform. 2012 Jul 30;9(1):208. PMCID: PMC3482100

187. Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circ Res. 2012 Nov 09;111(11):1446-58. PMCID: PMC3494760

188. Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD. Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metab. 2012 Oct 03;16(4):462-72. PMCID: PMC3474846

189. Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension. 2013 Mar;61(3):716-22. PMCID: PMC3573251

190. Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD. Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):523-32. PMCID: PMC3573264

191. Pelham CJ, Keen HL, Lentz SR, Sigmund CD. Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. Am J Physiol Regul Integr Comp Physiol. 2013 May 01;304(9):R690-701. PMCID: PMC3652079

192. Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R818-28. PMCID: PMC3652167

193. Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD. Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. Hypertension. 2013 Jul;62(1):41-7. PMCID: PMC3718031

194. Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner ML, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, Grumbach IM. Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Hypertension. 2013 Aug;62(2):434-41. PMCID: PMC3868483

195. Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. Hypertension. 2014 Jul;64(1):141-8. PMCID: PMC4057298

196. Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD. Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. Hypertension. 2014 Sep;64(3):590-6. PMCID: PMC4134389

197. Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R376-86. PMCID: PMC4137154

198. Ramkumar N, Stuart D, Rees S, Hoek AV, Sigmund CD, Kohan DE. Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F931-8. PMCID: PMC4200300

199. Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS One. 2014;9(8):e103786. PMCID: PMC4133177

200. De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM. Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation. Hypertension. 2014 Nov;64(5):1088-93. PMCID: PMC4192060

201. De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM. Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension. 2015 Feb;65(2):345-51. PMCID: PMC4289099

202. Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R138-49. PMCID: PMC4297861

203. Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. Am J Physiol Regul Integr Comp Physiol. 2015 Feb 15;308(4):R238-49. PMCID: PMC4347751

204. Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015 Jan 01;3(1). PMCID: PMC4387753

205. Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):838-44. PMCID: PMC4376629

206. Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension. 2015 Jun;65(6):1341-8. PMCID: PMC4433403

207. Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD. Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension. 2015 Jul;66(1):211-20. PMCID: PMC4465866

208. Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. J Am Heart Assoc. 2015 Jun 15;4(6):e001949. PMCID: PMC4599535

209. Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem. 2015 Jul 31;290(31):19208-17. PMCID: PMC4521042

210. Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. PMCID: PMC4591368

211. Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD. Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. Physiol Genomics. 2016 Feb;48(2):124-34. PMCID: PMC4729699

212. Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD. Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol. 2016 Jan 01;310(1):H39-48. PMCID: PMC4796462

213. Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2016 Jan;67(1):214-22. PMCID: PMC4679422

214. Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD. Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):466-74. PMCID: PMC4767592

215. Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. 2016 May;67(5):992-9. PMCID: PMC4833511

216. Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD. Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics. 2016 Jul 01;48(7):491-501. PMCID: PMC4967222

217. Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology. 2016 Aug;157(8):3140-8. PMCID: PMC4967111

218. Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N. Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. PLoS One. 2016;11(7):e0159872. PMCID: PMC4965005

219. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 09;16(6):1548-1560. PMCID: PMC4981564

220. Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM. Role of CaMKII in Ang-II-dependent small artery remodeling. Vascul Pharmacol. 2016 Dec;87:172-179. PMCID: PMC5164857

221. Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension. 2016 Dec;68(6):1385-1392. PMCID: PMC5159235

222. Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD. Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology. 2016 Nov;157(11):4266-4275. PMCID: PMC5086539

223. Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD. Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight. 2016 Nov 17;1(19):e91015. PMCID: PMC5111503

224. Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD. Retinol-binding protein 7 is an endothelium-specific PPAR<b>γ</b> cofactor mediating an antioxidant response through adiponectin. JCI Insight. 2017 Mar 23;2(6):e91738. PMCID: PMC5358481

225. Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 01;312(6):R973-R981. PMCID: PMC5495920

226. Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD. Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. Hypertension. 2017 Jul;70(1):174-182. PMCID: PMC5472224

227. De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM. Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension. 2017 Sep;70(3):559-565. PMCID: PMC5552422

228. Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension. 2017 Nov;70(5):990-997. PMCID: PMC5679092

229. Woll AW, Quelle FW, Sigmund CD. PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium. Physiol Genomics. 2017 Nov 01;49(11):653-658. PMCID: PMC5792137

230. Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiol Genomics. 2017 Dec 01;49(12):722-732. PMCID: PMC5814669

231. Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA. Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. JCI Insight. 2017 Dec 21;2(24). PMCID: PMC5752287

232. Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, Feng Y. Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. Am J Physiol Heart Circ Physiol. 2018 Mar 01;314(3):H580-H592. PMCID: PMC5899258

233. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT_1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. Am J Physiol Regul Integr Comp Physiol. 2018 Jun 01;314(6):R770-R780. PMCID: PMC6032302

234. Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. Clin Sci (Lond). 2018 Feb 14;132(3):419-436. PMCID: PMC5947858

235. De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. Hypertension. 2018 Jul;72(1):227-234. PMCID: PMC6002945

236. Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH. Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension. Am J Physiol Renal Physiol. 2018 Oct 01;315(4):F1006-F1018. PMCID: PMC6230741

237. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. JCI Insight. 2018 Oct 04;3(19). PMCID: PMC6237463

238. Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD. Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension. 2018 Nov;72(5):1227-1235. PMCID: PMC6209120

1. Ryan MJ, Sigmund CD. Use of transgenic and knockout strategies in mice. Semin Nephrol. 2002 Mar;22(2):154-60.

2. Lavoie JL, Sigmund CD. Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system. Endocrinology. 2003 Jun;144(6):2179-83.

3. Ryan MJ, Sigmund CD. ACE, ACE inhibitors, and other JNK. Circ Res. 2004 Jan 09;94(1):1-3.

4. Stec DE, Davisson RL, Sigmund CD. Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. Trends Cardiovasc Med. 1998 Aug;8(6):256-64.

5. Sigmund CD, Davisson RL. Targeting brain AT1 receptors by RNA interference. Hypertension. 2006 Feb;47(2):145-6.

6. Dickson ME, Sigmund CD. Genetic basis of hypertension: revisiting angiotensinogen. Hypertension. 2006 Jul;48(1):14-20.

7. Weatherford ET, Itani H, Keen HL, Sigmund CD. Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin? Hypertension. 2007 Nov;50(5):844-6.

8. Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda). 2008 Aug;23:187-93. PMCID: PMC2538674

9. Rahmouni K, Sigmund CD. Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression. Circ Res. 2008 Sep 12;103(6):565-7. PMCID: PMC2728444

10. Sigmund CD. Team exercise. Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R1.

11. Santillan MK, Santillan DA, Sigmund CD, Hunter SK. From molecules to medicine: a future cure for preeclampsia? Drug News Perspect. 2009 Nov;22(9):531-41.

12. Gross KW, Gomez RA, Sigmund CD. Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin". Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1209-11. PMCID: PMC3597226

13. Sigmund CD. Structural biology: On stress and pressure. Nature. 2010 Nov 04;468(7320):46-7.

14. Rahmouni K, Davisson RL, Sigmund CD. Inflaming hypothalamic neurons raises blood pressure. Cell Metab. 2011 Jul 06;14(1):3-4. PMCID: PMC3131053

15. Norris AW, Sigmund CD. A second chance for a PPARγ targeted therapy? Circ Res. 2012 Jan 06;110(1):8-11. PMCID: PMC3583552

16. Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Arch. 2013 Jan;465(1):167-75. PMCID: PMC3569511

17. Quelle FW, Sigmund CD. PPARγ: no SirT, no service. Circ Res. 2013 Feb 01;112(3):411-4. PMCID: PMC3580855

18. Sigmund CD. A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):676-8. PMCID: PMC3905617

19. Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. Hypertension. 2014 Dec;64(6):1182-3.

20. Ketsawatsomkron P, Sigmund CD. Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. Curr Opin Nephrol Hypertens. 2015 Mar;24(2):123-30. PMCID: PMC4384504

21. Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: the missing link for preeclampsia? Am J Physiol Regul Integr Comp Physiol. 2015 Nov 01;309(9):R1062-4. PMCID: PMC4666952

22. Stump M, Mukohda M, Hu C, Sigmund CD. PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep. 2015 Dec;17(12):89. PMCID: PMC6766749

23. Wu J, Sigmund CD. Hypertension: A Disease That Strikes Around the Clock. Hypertension. 2016 Mar;67(3):493-5. PMCID: PMC4819989

24. Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension. 2016 Apr;67(4):674-80. PMCID: PMC5135412

25. Keen HL, Sigmund CD. Microarray Analysis of Hypertension. Methods Mol Biol. 2017;1527:41-52.

26. Nakagawa P, Sigmund CD. How Is the Brain Renin-Angiotensin System Regulated? Hypertension. 2017 Jul;70(1):10-18. PMCID: PMC5511499

27. Yosten GLC, Adams JC, Bennett CN, Bunnett NW, Scheman R, Sigmund CD, Yates BJ, Zucker IH, Samson WK. Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals. Am J Physiol Regul Integr Comp Physiol. 2018 Dec 01;315(6):R1251-R1253.

28. Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S. Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology. Physiol Rev. 2018 Jul 01;98(3):1627-1738. PMCID: PMC6335102

29. Sigmund CD, Diz DI, Chappell MC. No Brain Renin-Angiotensin System: Déjà vu All Over Again? Hypertension. 2017 Jun;69(6):1007-1010. PMCID: PMC5497704

30. Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD. RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. J Clin Invest. 2019 Mar 21;129(6):2318-2332. PMCID: PMC6546477

31. Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension. 2019 Jul;74(1):173-183. PMCID: PMC6561821

32. Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD. Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension. JCI Insight. 2019 Jun 11;5(14). PMCID: PMC6675584

33. Sigmund CD. AJP: Regulatory, Integrative and Comparative Physiology: 1 Year later.... American Journal of Physiology - Regulatory Integrative and Comparative Physiology. October 2008;295(4).

34. Jones CA, Fabian JR, Abel KJ, Sigmund CD, Gross KW. The regulation of renal and extrarenal renin gene expression in the mouse Cellular and Molecular Biology of the Renin-Angiotensin System. 1 January 2018:33-57.

35. Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, De Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARγ signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling (Hypertension (2008) 51, (867-871)) Hypertension. April 2008;51(4).

36. Sigmund CD. AJP: Regulatory, Integrative and Comparative Physiology: 2007 And beyond American Journal of Physiology - Regulatory Integrative and Comparative Physiology. July 2007;293(1).

37. Sigmund CD. Editors' note Hypertension. June 2007;49(6):1195.

38. Catanzaro DF, Sun J, Gilbert MT, Yan Y, Black T, Sigmund C, Gross KW. A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells. Kidney Int. 1994 Dec;46(6):1513-5.

39. Ding Y, Davisson RL, Hardy PO, Sinclair NE, Robbins L, Catterall JF, Sigmund CD. Kidney-specific expression of the human angiotenslnogen gene under the control of the kidney androgenregulated protein promoter in transgenic mice FASEB Journal. 1996;10(3).

40. Merrill DC, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. Cardiovascular control in conscious transgenic mice carrying human renin and human angiotensinogen genes FASEB Journal. 1996;10(3).

41. Ding Y, Davisson RL, Hardy DO, Zhu LJ, Catterall JF, Sigmund CD. Inducible hypertension in transgenic mice containing the human angiotensinogen gene under the control of the kidney androgen-regulated protein promoter FASEB Journal. 1997;11(3).

42. Sinn PL, Lang JA, Sigmund CD. Post-transcriptional regulation of human renin messenger RNA in Calu-6 cells FASEB Journal. 1997;11(3).

43. Stec DE, Davisson RL, Sigmund CD. Transgenesis and gene targeting in the mouse: Tools for studying genetic determinants of hypertension Trends in Cardiovascular Medicine. August 1998;8(6):256-264.

44. Merrill DC, Smith SB, Sigmund CD. Differential regulation of human renin gene expression during the estrous cycle in transgenic mice FASEB Journal. 20 March 1998;12(5).

45. Davisson RL, Merrill DC, Sigmund CD. Evidence for vascular remodeling but not enhanced sympathetic drive in the chronic hypertension exhibited by transgenic mice containing both the human renin and human angiotensinogen genes (RA+) FASEB Journal. 1997;11(3).

46. Davidge B, Rebola KGO, Agbor LN, Sigmund CD, Singer JD. Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E. J Cell Sci. 2019 Nov 06;132(21). PMCID: PMC6857591

47. Fang S, Sigmund CD. PPARγ and RhoBTB1 in hypertension. Curr Opin Nephrol Hypertens. 2020 Mar;29(2):161-170. PMCID: PMC7087486

48. Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Curr Hypertens Rep. 2020 Jan 10;22(1):7. PMCID: PMC7101821

49. Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension. 2020 Feb;75(2):569-579. PMCID: PMC7027931

50. Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol. 2020 May 01;318(5):R855-R869. PMCID: PMC7272763

51. Sigmund CD, Carey RM, Appel LJ, Arnett DK, Bosworth HB, Cushman WC, Galis ZS, Green Parker M, Hall JE, Harrison DG, McDonough AA, Nicastro HL, Oparil S, Osborn JW, Raizada MK, Wright JD, Oh YS. Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation. Hypertension. 2020 Apr;75(4):902-917. PMCID: PMC7067675

52. Sigmund CD, Grobe JL. A colorful view of the brain renin-angiotensin system. Hypertens Res. 2020 Apr;43(4):357-359. PMCID: PMC7107486

53. Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. Cardiovasc Res. 2021 Jan 01;117(1):308-319. PMCID: PMC7797211

54. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 Aug;76(2):589-597. PMCID: PMC7347451

55. Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension. 2020 Aug;76(2):468-477. PMCID: PMC7347438

56. Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. Hypertension. 2020 Dec;76(6):1800-1807. PMCID: PMC7706825

57. Wu J, McCormick JA, Sigmund CD. Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure. Curr Hypertens Rep. 2020 Aug 27;22(9):61. PMCID: PMC7477742

58. Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. β-Arrestin-Biased Agonist Targeting the Brain AT₁R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2021 Feb;77(2):420-431. PMCID: PMC7855825

59. Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension. 2021 Apr;77(4):1061-1068. PMCID: PMC7990288

60. Fang S, Livergood MC, Nakagawa P, Wu J, Sigmund CD. Role of the Peroxisome Proliferator Activated Receptors in Hypertension. Circ Res. 2021 Apr 02;128(7):1021-1039. PMCID: PMC8020861

61. Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. Hypertension. 2021 Apr;77(4):1399-1411. PMCID: PMC7946772

62. Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. PLoS One. 2021;16(7):e0250807. PMCID: PMC8318244

63. Nakagawa P, Sigmund CD. Under Pressure: A Baroreceptor Mechanism in the Renal Renin Cell Controlling Renin. Circ Res. 2021 Jul 09;129(2):277-279. PMCID: PMC8274374

64. Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S. Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Hypertension. 2021 Jun;77(6):1857-1866. PMCID: PMC8986150

65. Wu J, Sigmund CD. Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench. Hypertension. 2022 Jan;79(1):76-78. PMCID: PMC8667228

66. Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Methods for the Comprehensive <i>in vivo</i> Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. Front Physiol. 2022;13:855054. PMCID: PMC8914175

67. Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL. Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 01;322(6):R467-R485. PMCID: PMC9054347

68. Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. Function (Oxf). 2022;3(3):zqac017. PMCID: PMC9045850

69. Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL. Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiol Genomics. 2022 Jun 01;54(6):196-205. PMCID: PMC9131927

70. Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD Jr, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization. JCI Insight. 2022 May 09;7(9). PMCID: PMC9090250

71. Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR. Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. Front Synaptic Neurosci. 2022;14:910820. PMCID: PMC9280690

72. Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 01;323(4):R410-R421. PMCID: PMC9512112

73. Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD. ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. Hypertension. 2022 Nov;79(11):2480-2492. PMCID: PMC9669141

74. Xu C, Chen Y, Ramkumar N, Zou CJ, Sigmund CD, Yang T. Collecting duct renin regulates potassium homeostasis in mice. Acta Physiol (Oxf). 2023 Jan;237(1):e13899. PMCID: PMC10754139

75. Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL. Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (<i>Rgs2</i>) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice. Hypertension. 2022 Dec;79(12):2843-2853. PMCID: PMC9649888

76. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner JA, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites. bioRxiv. 2023 May 03. PMCID: PMC10187200

77. Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE. Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. Front Cell Neurosci. 2023;17:1207350. PMCID: PMC10244568

78. Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P. Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. Function (Oxf). 2023;4(5):zqad043. PMCID: PMC10440998

79. Kumar G, Fang S, Golosova D, Lu KT, Brozoski DT, Vazirabad I, Sigmund CD. Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination. Function (Oxf). 2023;4(5):zqad034. PMCID: PMC10413933

80. Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL. Angiotensin AT_1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity. Cell Rep. 2023 Aug 29;42(8):112935. PMCID: PMC10530419

81. Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL. Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. Hypertension. 2023 Sep;80(9):1871-1880. PMCID: PMC10528934

82. Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD. Insights Into the Role of Angiotensin-II AT₁ Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. Hypertension. 2024 Jan;81(1):6-16. PMCID: PMC10787814

83. SenthilKumar G, Mathieu NM, Freed JK, Sigmund CD, Gutterman DD. Addressing the decline in graduate students' mental well-being. Am J Physiol Heart Circ Physiol. 2023 Oct 01;325(4):H882-H887.

84. Sigmund CD. The 2023 Walter B. Cannon Award Lecture: Mechanisms Regulating Vascular Function and Blood Pressure by the PPARγ-RhoBTB1-CUL3 Pathway. Function (Oxf). 2024;5(1):zqad071. PMCID: PMC10775765

85. Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL. Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling. Sci Adv. 2023 Dec;9(48):eadg8118. PMCID: PMC10691776

86. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner J, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites. Sci Adv. 2024 Feb 16;10(7):eadj7481. PMCID: PMC10866565

87. Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253. PMCID: PMC11213288

88. Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. Physiol Genomics. 2024 Mar 01;56(3):265-275. PMCID: PMC10866620

89. Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD. Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. Hypertension. 2024 Jun;81(6):1332-1344. PMCID: PMC11096025

90. Medrano S, Yamaguchi M, Almeida LF, Smith JP, Yamaguchi H, Sigmund CD, Sequeira-Lopez MLS, Gomez RA. An efficient inducible model for the control of gene expression in renin cells. Am J Physiol Renal Physiol. 2024 Sep 01;327(3):F489-F503. PMCID: PMC11460331

91. Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL. Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence. Hypertension. 2024 Nov;81(11):2209-2217. PMCID: PMC11483214

92. Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL. Early-Life Sodium Restriction Programs Autonomic Dysfunction and Salt- Sensitivity in Male C57BL/6J Mice. Am J Physiol Regul Integr Comp Physiol. 2024 Nov 16.