CURRICULUM VITAE
Daochun Sun PhD
Daochun Sun PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-8158 |
EDUCATION: |
1998 - 2002 B.S., Yantai University, Yantai, China |
06/2003 - 06/2006 M.S., Beijing Institute of Radiation Medicine, Beijing, China |
07/2006 - 08/2012 Ph.D., School of Medicine, Wayne State University, Detroit, MI |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/2012 - 06/2015 Postdoc Fellow, Developmental Biology, University of Texas, Southwestern Medical Center |
07/2015 - 02/2021 Research Associate, Cell Biology and Genetics, Memorial Sloan Kettering Cancer Center |
FACULTY APPOINTMENTS: |
03/2021 - Present Assistant Professor, Department of Pediatrics, Medical College of Wisconsin |
03/2021 - Present Assistant Professor, Cell Biology, Neurology and Anatomy, Medical College of Wisconsin |
05/2021 - Present Member, Cancer Center |
AWARDS AND HONORS: |
2008 “Out of Box” Hypothesis Competition Award, School of Medicine, Wayne State University |
2010 Graduate Travel Award |
2011 - 2012 Graduate Research Award |
2020 NF Hackathon Award for Drug Discovery, Children's Tumor Foundation |
06/2021 - Present NGS-Based Pilot Projects-Sequencing, Bioinformatics, and Analysis Award, Genomic Science and Precision Medicine Center, Medical College of Wisconsin |
07/2021 - 06/2022 New Faculty Pilot Grant, Research Affairs Committee, Medical College of Wisconsin |
10/01/2021 - 12/31/2021 RASopathies Drug Discovery Incubation Award, RASopathies Networks |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2010 - Present American Association of Cancer Research |
2016 - 2018 International Society of Computation Biology |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
03/01/2023 - 09/01/2023 Cancers |
Editorial Board |
08/2013 - Present Current Bioinformatics |
10/01/2021 - 10/01/2023 Animal Models and Experimental Medicine |
Journal Review |
2014 - 2020 BioMedicine |
2014 - 2021 PlosOne |
10/2022 - Present Cancers |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Targeting Cancer Stem Cell in NF1, Department of Cell Biology Seminar, MCW, 12/09/2021 |
Targeting Neurofibromatosis Type 1, Department of Biochemistry Seminar Series, Medical Colleague of Wisconsin, 02/09/2022 |
Targeting Tumor Heterogeneity in Plexiform Neurofibromas, Cancer Center Seminar Series 2023, Medical College of Wisconsin, 01/13/2023 |
International |
Cancer Stem Cells as the Target for MPNST Tumorigenesis and Relapse, NF Conference, Washington D.C., 06/2017 |
Drug Targets in Plexiform Neurofibroma by data mining, NF Hackathon 2020, Online, 11/2020 |
Biological data mining in Children's rare disease, Hack4Rare 2021, Children's Tumor Foundation, Online, 06/2021 |
INSTITUTE FOR CLINICAL & TRANSLATIONAL SCIENCE, UNIVERSITY OF CALIFORNIA, IRVINE: |
03/2022 - 04/2023 Reviewer for grant |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Bo X, Lou S, Sun D, Yang J, Wang S. AOBase: a database for antisense oligonucleotides selection and design. Nucleic Acids Res. 2006 Jan 01;34(Database issue):D664-7. PMCID: PMC1347428 |
2. Bo X, Lou S, Sun D, Shu W, Yang J, Wang S. Selection of antisense oligonucleotides based on multiple predicted target mRNA structures. BMC Bioinformatics. 2006 Mar 09;7:122. PMCID: PMC1421440 |
3. Huang M, Wang Y, Sun D, Zhu H, Yin Y, Zhang W, Yang S, Quan L, Bai J, Wang S, Chen Q, Li S, Xu N. Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis. BMC Cancer. 2006 Sep 07;6:221. PMCID: PMC1574340 |
4. Sun Y, Sun D, Li F, Tian L, Li C, Li L, Lin R, Wang S. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung Cancer. 2007 Oct;58(1):21-9. |
5. Kraniak JM, Sun D, Mattingly RR, Reiners JJ Jr, Tainsky MA. The role of neurofibromin in N-Ras mediated AP-1 regulation in malignant peripheral nerve sheath tumors. Mol Cell Biochem. 2010 Nov;344(1-2):267-76. PMCID: PMC3809002 |
6. Sun D, Tainsky MA, Haddad R. Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy. Transl Oncogenomics. 2012;5:1-7. PMCID: PMC3273949 |
7. Sun D, Haddad R, Kraniak JM, Horne SD, Tainsky MA. RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST. Mol Cancer Res. 2013 Jun;11(6):616-27. |
8. Alcantara Llaguno SR, Wang Z, Sun D, Chen J, Xu J, Kim E, Hatanpaa KJ, Raisanen JM, Burns DK, Johnson JE, Parada LF. Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. Cancer Cell. 2015 Oct 12;28(4):429-440. PMCID: PMC4607935 |
9. Alcantara Llaguno S, Sun D, Pedraza AM, Vera E, Wang Z, Burns DK, Parada LF. Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction. Nat Neurosci. 2019 Apr;22(4):545-555. PMCID: PMC6594191 |
10. Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346. PMCID: PMC6655586 |
11. Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Cell Lineage-Based Stratification for Glioblastoma. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. PMCID: PMC7494533 |
12. Xie XP, Laks DR, Sun D, Poran A, Laughney AM, Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF. High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31448-31458. PMCID: PMC7733854 |
13. Dai JM, Sun DC, Lin RX, Yang J, Lou S, Wang SQ. Microarray analysis of differentially expressed genes in mouse bone marrow tissues after ionizing radiation. Int J Radiat Biol. 2006 Jul;82(7):511-21. |
14. Sun Y, Sun D, Li F, Tian L, Li C, Li L, Lin R, Wang S. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung Cancer. 2007 Oct;58(1):21-9. |
15. Sun D, Xie XP, Zhang X, Wang Z, Sait SF, Iyer SV, Chen YJ, Brown R, Laks DR, Chipman ME, Shern JF, Parada LF. Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. Cell Stem Cell. 2021 Aug 05;28(8):1397-1410.e4. PMCID: PMC8349880 |
16. Xie XP, Laks DR, Sun D, Ganbold M, Wang Z, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou X, Parada LF. Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. Dev Cell. 2022 Jan 10;57(1):32-46.e8. PMCID: PMC8820651 |
17. Sun D. Brief biography of Daochun sun Current Bioinformatics. 1 March 2015;10(1):1. |
18. Brown RM, Farouk Sait S, Dunn G, Sullivan A, Bruckert B, Sun D. Integrated Drug Mining Reveals Actionable Strategies Inhibiting Plexiform Neurofibromas. Brain Sci. 2022 May 31;12(6). PMCID: PMC9221468 |
