Medical College of Wisconsin
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CURRICULUM VITAE

Denise S. Uyar MD
Professor
Department of Obstetrics and Gynecology
Division of Gynecologic Oncology

OFFICE ADDRESS:
Clinical Cancer Center
9200 W Wisconsin Ave
Milwaukee, WI 53226
Phone: 414-805-6623

EDUCATION:
1988 Academy of Saint Joseph High School, Brentwood, Brentwood, NY
1992 B.A., Hamilton College, Clinton, NY
1997 M.D., University of Vermont Medical College, Burlington, VT

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1997 - 2001 Resident, Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT
2000 - 2004 Fellow, Division of Gynecology Oncology, Cleveland Clinic Foundation, Cleveland, OH
2000 - 2001 Administrative Chief Resident, Dept. Obstetrics and Gynecology, University of Vermont, Burlington, VT

FACULTY APPOINTMENTS:
09/2004 - Present Assistant Professor, Department of Obstetrics and Gynecology, Division of Gynecology Oncology, Medical College of Wisconsin, Milwaukee, WI
Associate Professor, OB/GYN, Gynecology Oncology, Medical College of Wisconsin

ADMINISTRATIVE APPOINTMENTS:
Division Director, Gynecology Oncology

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
M4 Student Clerkship Director, Gynecology Oncology

HOSPITAL STAFF PRIVILEGES:
10/2004 - Present Froedtert Memorial Lutheran Hospital, 9200 W.Wisconsin Ave., Milwaukee, WI 53226
10/2004 - Present Waukesha Memorial Hospital, 725 American Avenue, Waukesha, WI 53188
10/2004 - Present Community Memorial Hospital, W180 N8085 Town Hall Road, Menomonee Falls, WI 53051
10/2004 - Present Children’s Hospital of Wisconsin, 9000 W. Wisconsin Ave, Wauwatosa, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Obstetrics and Gynecology
01/2007
01/2012
American Board of Obstetrics and Gynecology, Subspecialty, Gynecology Oncology
04/2009
12/2015
   
Certificates
Issued By Issue DateExpiration
Robotic Certification
da Vinci Surgical Systems
10/26/2009
10/26/2009
    

Licensure
Number Issue DateExpiration
Ohio
35-07-9051-U
07/2001
10/2005
Wisconsin
47418
08/2004
10/31/2013
    

AWARDS AND HONORS:
1990 - 1992 Dean’s List , Hamilton College, Clinton, NY
06/2001 Performing Outstanding Excellence Together (POET) Award
2011 Best Doctors of America

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
10/2004 - Present Gynecological Oncology Group (Affiliate Member)
09/2005 - Present American College of Obstetricians and Gynecologists (Diplomat)
05/2007 - Present Milwaukee Gynecologic Society (Member)
10/2009 - Present Society of Gynecology Oncology (Full Member)
10/2010 - Present American Society of Clinical Oncology (Active Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
2006 Obstetrics and Gynecology
2009 Gynecology Oncology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
06/2006 - 06/2008 Alternate, Faculty Council, Medical College of Wisconsin
06/2006 - 06/2011 Member, Library Committee, Medical College of Wisconsin
12/2007 - Present Member, Patient Care Services, Supply Evaluation and Acquisition Committee, Froedtert Memorial Lutheran Hospital
12/2008 - 12/2010 Member, Physician Satisfaction Committee, Froedtert Memorial Lutheran Hospital
09/2009 - Present Member, Faculty Council, Medical College of Wisconsin
03/2010 - 06/2011 Member, Department of Obstetrics and Gynecology Education Committee; internal department committee initiated to restructure resident education and create 2 year cycling curriculum for OB/GYN residency, Medical College of Wisconsin
04/30/2010 Member, LCME Self- Study Subcommittee on Faculty, Phase 2, Medical College of Wisconsin

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Utilizing Peer Teen Advocates to Increase HPV Vaccination Rates in Adolescents
Source:
HWPP
Role:
Principal Investigator
Dates:
01/01/2012 - Present
Direct Funds:
$200,000
  
Non-Peer Review
Title:
Identification of molecular epigenetic biomarkers in endometrial cancer.
Source:
Froedtert Foundation Grant
Role:
Principal Investigator
Dates:
08/01/2011 - 07/31/2013
Direct Funds:
$25,700
  
Title:
Potential biomarkers for endometrial cancer.
Source:
Mead Witter Foundation, Inc
Role:
Principal Investigator
Dates:
08/2011 - 08/2013
Direct Funds:
$100,000
  
Prior
Peer Review
Title:
T Regulatory Cells in Early Endometrial Cancer Before and After Treatment
Source:
American Cancer Society Grant
Role:
Principal Investigator
Dates:
06/2008 - 06/2010
Direct Funds:
$30,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
D. Uyar, Cervical cancer review, Froedtert Memorial Lutheran Hospital Grand Rounds Presentation, Department of Obstetrics and Gynecology, 10/27/2004
D. Uyar, Surgical risks in the elderly, Froedtert Memorial Lutheran Hospital Grand Rounds Presentation, Department of Obstetrics and Gynecology, 02/09/2005
D. Uyar, BRCA testing and breast MRI recommendations, Froedtert Memorial Lutheran Hospital Resident Lecture, Department of Obstetrics and Gynecology, 04/13/2007
D. Uyar, Ovarian Cancer: Key Concepts, Hematology Oncology Fellowship Core Lecture, Froedert Memorial Lutheran Hospital, 06/03/2008
D. Uyar, Ovarian Cancer, Hematology Oncology Fellowship Core Lecture Series, 05/27/2011
 
Regional
D. Uyar, Laparoscopic Management of the Adnexal Mass, Cleveland Clinic Department of Obstetrics and Gynecology Update on Endoscopy Post-Graduate Course, Cleveland, OH, 02/27/2003
D. Uyar, Laparoscopic Management of the Adnexal Mass, Cleveland Clinic Department of Obstetrics and Gynecology Update on Endoscopy Post-Graduate Course, Cleveland, OH, 02/26/2004 - 02/27/2004
D. Uyar, Long term use of pegylated doxorubicin and establishing monitoring criteria, Cleveland Society of Obstetricians and Gynecologists Resident and Fellow Research Day, Cleveland Hilton South, Independence, OH, 05/19/2004
D. Uyar, Red Flags for the Primary Care Physician, Watertown Hospital, Grand Rounds, Watertown, WI, 04/21/2005
D. Uyar, Cervical Dysplasia, Medical College of Wisconsin 7th Annual Women’s Health Conference Post-Graduate Course, Brookfield, WI, 04/22/2005
D. Uyar, Ovarian Cancer Screening, Wisconsin Cancer Risk Program Network Meeting, Children’s Hospital of Wisconsin, Milwaukee, WI, 05/13/2005
D. Uyar, Update on Ovarian Cancer and Screening, Theda Care Hospital, Continuing Medical Education Lecture, Neenah, WI, 09/08/2005
D. Uyar, Strategies for Gynecologic Cancer Screening and Diagnosis: Red Flags for the Primary Care Physician, Continuing Medical Education Lecture, County Springs Hotel, Waukesha, WI, 11/04/2005
D. Uyar, Prophylactic Oophorectomy – Who? When? Why?, Medical College of Wisconsin 8th Annual Women’s Health Care Conference Post-Graduate Course, Sheraton Hotel, Brookfield, WI, 03/31/2006
D. Uyar, Case Discussion Session, Medical College of Wisconsin 9th Annual Women’s Health Care Conference Post-Graduate Course, Sheraton Hotel, Brookfield, WI, 04/20/2007
D. Uyar, HPV Vaccination Guidelines, Community Memorial Hospital Medical Staff Education Meeting Presentation, Menomonee Falls, WI, 08/03/2007
D. Uyar, Vulvar Intraepithelial Neoplasia, 12th Annual Women’s Health Conference, Brookfield Suites, Brookfield, WI, 04/23/2010
D. Uyar, Laparoscopy in Gynecology Oncology, Oncology, Fairview Hospital, Grand Rounds Guest Speaker, Cleveland, OH
 
National
D. Uyar, N. Takigawa, T. Mekhail, D. Grabowski, M. Markman, F. Lee, R. Canetta, R. Peck, R. Bukowski, R. Ganapathi, Apoptotic pathways regulating the antitumor activity of the novel epothilone BMS 247550 in drug resistant ovarian cancer, The 2002 GlaxoSmithKline National Gynecologic Oncology Fellows’ Forum, Coral Gables, FL, 02/14/2002 - 02/17/2002
D. Uyar, N. Takigawa, T. Mekhail, D. Grabowski, M. Markman, F. Lee, R. Canetta, R. Peck, R. Bukowski, R. Ganapathi, Apoptotic pathways regulating efficacy of the novel epothilone BMS 247550 in drug resistant ovarian cancer, 33rd Annual Meeting of the Society of Gynecologic Oncologist, Miami, FL, 03/16/2002 - 03/20/2002
D. Uyar, N. Takigawa, T. Mekhail, D. Grabowski, M. Markman, F. Lee, R. Canetta, R. Peck, R. Bukowski, R. Ganapathi, Characterization of cell death mechanisms of BMS 310705, an epothilone derivative, 93rd Annual Meeting of the American Association of Cancer Research, San Francisco, CA, 04/06/2002 - 04/10/2002
D. Uyar, G. Eltabbakh, S. Mount, The positive predictive value of liquid-based and conventional Papanicolaou smears reported as malignant, 22nd Annual New England Association of Gynecology Oncologist, Martha’s Vineyard, MA, 06/07/2002 - 06/09/2002
D. Uyar, Review of Endometrial Cancer, Department of Obstetrics and Gynecology Grand Rounds, Louisiana State University, New Orleans, LA, 10/27/2003
D. Uyar, B. Kulp, G. Peterson, K. Zanotti, K. Webster, J. Belinson, M. Markman, Long term use of pegylated doxorubicin and establishing monitoring criteria, 35th Annual Meeting of the Society of Gynecologic Oncologists, San Diego, CA, 02/07/2004 - 02/11/2004
D. Uyar, B. Kulp, G. Peterson, K. Zanotti, K. Webster, J. Belinson, M. Markman, Long term use pegylated doxorubicin and establishing monitoring criteria, GlaxoSmithKline National Gynecologic Oncology Fellows Forum, San Diego, CA, 03/2004
D. Uyar, M. Markman, H. Frasure, V. von Gruenigen, Treatment patterns by decade of life in elderly (>70 years) patient’s with ovarian cancer, 36th Annual Meeting of the Society of Gynecology Oncologist, Miami, FL, 03/19/2005 - 03/23/2005
F. Simpkins, A. Nickles Fader, A. Ladanyi, D. Uyar, R. DeBernardo, P. Rose, C. Michener, Prolonged treatment (>10 cycles) with pegylated liposomal doxorubicin for stable disease in patients with recurrent ovarian carcinoma, 38th Annual Meeting of Society of Gynecology Oncology, San Diego, CA, 05/03/2007 - 05/07/2007
B. Wakim, M. Pereckas, M. Li, A. Greene, A. Kajdacsy-Balla, D. Uyar, J. Osborne, and B. Halligan, Comparing serum proteomes from endometrial cancer patients to that from healthy volunteers: Identification of potential biomarkers for the early detection of the disease, The 21st Symposium of the Protein Society, Boston, MA, 07/21/2007 - 07/27/2007
B. Bonacci, B. Wakim, L. Reddy, E. Hammelev, J. Osborne, W. Bradley, J. Verbsky, D. Uyar, Induced T regulatory cells: a potential role in the tumorigenesis of endometrial cancer, Society of Gynecology Oncology, 41st Annual Meeting on Women’s Cancer, San Francisco, CA, 03/14/2010 - 03/17/2010
K. Brown, MD, L. Moraski, DO, A. Warwick, MD, D. Uyar, MD, J. Fenzel, MBA, MC, K. Marcdante, MD, J. Rehm, J. Sebastian, MD, D. Simpson, PhD, Docere Faculty Development Collaborative, Creating a Dialogue about Education Using "This I Believe ... about Teaching and Learning", Central Group on Educational Affairs Annual Spring Meeting, Chicago, IL, 04/08/2010 - 04/10/2010
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
10/2004 - Present M-3 Medical Student Clerkship Lecture: Gynecologic Cancers. Participate in lecture series given as part of the core curriculum
2004 - 2010 M-2 Pelvic Exam Teaching Sessions; Annual 2 hour sessions devoted to small group instruction of the pelvic exam
08/2006 - Present Staff Facilitator for the M-2 Medical Ethics and Palliative Medicine Course. Responsibilities include weekly meetings with student and faculty group members to discuss cases, lecture topics and review assignments each fall semester
01/2009 - 01/2010 Development and implementation of an online ANGEL curriculum for the 4th year medical students performing electives on the Gynecology Oncology service
08/2009 - Present M-3 Medical Student Clerkship Anatomy Lab. Review of pelvic anatomy in conjunction with models and clinical application. 2.5 hour practical lab with pelvic anatomy modeling administered once every 6 weeks as part of the core curriculum
01/2011 - Present Clinician Pathway Council Member
03/2011 - 05/2011 Facilitator and creator of M1 Team Based Learning Reproductive Medicine Module on Gynecologic Neoplasms
 
Resident and Fellow Education
10/2004 - Present Supervision and teaching of PGY2 and PGY3 residents during 7 week rotations on the Gynecology Oncology service
2008 - Present Hematology Oncology Fellow Didactic Core Lectures. Ovarian cancer lecture given as part of the core lectures for fellows
01/2009 - 01/2010 Development and implementation of an online ANGEL Gynecology Oncology Curriculum for the residents of the Gynecology Oncology rotation consisting of weekly modules, pre and post tests for modules, and one hour weekly didactic sessions for the 6 week rotation. Development of standardized surgical evaluation cards for residents on the Gynecology Oncology rotation in order to provide structured feedback regarding surgical performance
2011 - Present Currently in the process of developing Heme Onc Fellow rotation on the Gynecology Oncology service in conjunction with Heme Onc Department
 
Continuing Medical Education
10/2004 - Present Participate in weekly departmental CME activities such as Morbidity and Mortality conferences (1.5 hours). Weekly multidisciplinary Tumor Board and case review conference (1 hour)
12/2007 - 03/2010 Fellow, Docere Fellowship Program. Faculty development program designed to advance educators as teachers. Monthly 4 hour session devoted to augmenting faculty teaching methods, evaluation tools and collaboration. Under the guidance of this project the electronic curriculum for the residents and students in Gynecology Oncology was developed and implemented
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Julia Garcias, 02/2007 - 07/2007 Spring/summer student mentor
Tamara Leonard, 2011 - Present PGY2 research project development mentor
 

COMMUNITY SERVICE ACTIVITIES:
09/13/2005 Endometrial Cancer Awareness. Gynecology Oncology Awareness Month Community Lecture, Gilda’s Club, Milwaukee WI
09/20/2007 HPV Update: Vaccination Guidelines. Gynecology Oncology Awareness Month, Small Stones Health Resource Center, Brookfield, WI
01/2010 - Present Development and implementation of the Gynecology Oncology Educational and Support Group. Program developed for women diagnosed with gynecologic cancers and their families or friends. Incorporates once monthly informative sessions with social support to augment patient well being
06/17/2011 Community Memorial Hospital Medical Education Program. HPV Update
 

CLINICAL RESEARCH/ CLINICAL TRIALS:
Gynecologic Oncology Group (GOG) Medical College of Wisconsin Division of Gynecology Oncology is an affiliate member of the GOG under University of Wisconsin in Madison, WI Currently participate and work closely with our research staff in the recruitment, enrollment, and care of patients meeting protocol criteria with primary or recurrent endometrial, ovarian and cervical cancers.


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Chang, J. Luna, J. Giacolone, D. Uyar, G. A. Silverman, U. Franke. Regional localization of 56 new human chromosome 18-specific yeast artificial chromosomes. Cytogenetics and Cell Genetics 65; 136, 1994.
2. S. Gerken, K. Fish, D. Uyar, M.H. Polymeropoulos, P. Bradley, R. White, J. Overhauser,
3. G. A. Silverman. Integration of 28 STS's into the physical map of human chromosome 18. Genomics 24; 612, 1994.
4. K. Ghosh, D. Uyar, L. S. Downs, L. A. Padilla, L. F. Carson, D. Unger, K. E. Dusenberry. The role of whole abdominal radiation therapy in the management of advanced endometrial cancer (abstract). Intl J of Rad Onc Biol Physics, 48 (3), Suppl Jan 2000.
5. D. Uyar, N. Takigawa, T. Mekhail, D. Grabowski, M. Markman, F. Lee, R. Canetta, R. Peck, R. Bukowski, R. Ganapathi. Apoptotic pathways of epothilone BMS 310705. Gynecol Oncol 91;173-178, 2003.
6. D. Uyar, G. Eltabbakh, S. Mount. The positive predictive value of liquid-based and conventional Papanicolaou smears reported as malignant. Gynecol Oncol 89; 227-232, 2003.
7. S. Mount, M. Harmon, G. Eltabbakh, D. Uyar, G. Leiman. False positive diagnosis in conventional and liquid-based cervical specimens. Acta Cytol. 2004 May-June; 48(3):363-71.
8. D. Uyar, B. Kulp, G. Peterson, K. Zanotti, K. Webster, J. Belinson, M. Markman. Cardiac safety profile of prolonged (≥ 6 cycles) pegylated liposomal doxorubicin administration in patients with gynecologic malignancies. Gynecol Oncol. 2004 Jul; 94 (1):147-51.
9. D. Uyar, M. Markman, H. Frasure, V. von Gruenigen. Treatment patterns by decade of life in elderly (≥ 70 years) patient with ovarian cancer. Gynecol Oncol. 2005 Sep; 98 (3):403-8.
10. A.Harrington, E. Bell, M. Suchi, B. Behmaram, D. Uyar. Multifocal smooth muscle tumor of the vulva with an unusual intravascular growth pattern and local recurrence in a ten year old. Pediatr Dev Pathol. Nov 2010.
 
Books, Chapters, and Reviews
1. D. Uyar and P. Rose. Ovarian Cancer, Chapter 48, Clinical Gynecology, Bieber et al, Elsevier Publishing. June 30, 2006.
 
Editorials, Letters to Editor, Other
1. C. Wong, D. Uyar. Serum concentrations of cancer antigen 125 may be an independent predictor of disease free and overall survival for women with primary fallopian tube carcinoma (comment). Evidence-Based Oncology, June 2001.