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CURRICULUM VITAE

Elaine J. Tanhehco MD, PhD
Assistant Professor
Department of Radiology
Division of Neuroradiology

OFFICE ADDRESS:
Froedtert Hospital
9200 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
1993 - 1997 Bachelor of Science, University of Michigan, Ann Arbor, MI
1997 - 2000 PhD, Pharmacology, University of Michigan, Ann Arbor, MI
2012 - 2016 Medical Doctorate, University of Illinois College of Medicine, Chicago, IL

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
2016 - 2017 Resident Physician, Transition Year, St. Mary Mercy Hospital, Livonia, MI
2017 - 2021 Resident Physician, Radiology, AMITA Health St. Francis Hospital, Evanston, IL
2021 - 2022 Neuroradiology Fellow, Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL

HOSPITAL STAFF PRIVILEGES:
2022 - 2023 Assistant Professor, Radiology, University of Chicago, Pritzker School of Medicine, Chicago, IL
2023 - Present Assistant Professor, Radiology, Froedtert Hospital, Milwaukee, WI

AWARDS AND HONORS:
1996 Summer Fellowship, American Heart Association
1997 - 2000 Midwest Fellowship Pre-Doctoral Fellowship, American Heart Association
2001 Service Award Postdoctoral Fellowship, NIH-NHLBI National Research
2002 Development of Junior Scientists Grant, Henry Ford Hospital
2003 Small Business Innovation Research Phase I Award, National Institutes of Health
2013 James L. Ferguson Memorial Fund, Dept. of Physiology and Biophysics, University of Illinois College of Medicine

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2017 - Present Radiological Society of North America
2019 - Present American Society of Neuroradiology
2019 - Present American Roentgen Ray Society
2020 - Present American College of Radiology
2021 - Present Illinois Radiological Society
2021 - Present ACR Chapter - Illinois Chicago Physician

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
Gralinski MR, Tanhehco E, Barbeau DL, Gricius E, Cardiotoxicity of the hydroxylated metabolite of imipramine in the Langendorff isolated perfused rabbit heart, Poster Presented at the Safety Pharmacology Society annual meeting, Mannheim, Germany, 09/2005
 
National
Tanhehco EJ, Senese PB, Gralinski MR, Validation of the isolated rabbit heart for cardiovascular safety assessment, Poster Presented at the Society of Toxicology Annual Meeting March, New Orleans, Louisiana, 03/2005
Salvail D, Gralinski MR, Tanhehco E, Page G, Safety pharmacology: in vitro and ex vivo effects of uridine triphosphate on cardiac electrophysiology and hemodynamics, Poster Presented at the Society of Toxicology Annual Meeting, San Diego, California, 03/2006
Tanhehco EJ, Veits MD, Senese PB, Induced atrial fibrillation in the isolated rabbit heart, Poster Presented at the Society of Toxicology Annual Meeting, Charlotte, North Carolina, 03/2007
Lapinskas P, Tanhehco E, Senese P, Gralinski M, Schafer P, Sterling D, Laskin O, Examination of the cardiovascular effects of PDE inhibitors in the neonatal and adult isolated rabbit heart (Langendorff) Model, Poster Presented at the Society of Toxicology Annual Meeting, Seattle, Washington, 03/2008
Elsherif L, Bender IK, Wang H, Tanhehco EJ, Effects of heart rate and anesthesia on the severity of arrhythmias in the methoxamine-sensitized rabbit, Poster Presented at the Safety Pharmacology Society Annual Meeting, Madison, Wisconsin, 09/2008
Tanhehco EJ, Calandra JD, Subsegmental pulmonary embolisms - to treat or not to treat?, Poster Presented at the Chicago Radiological Society Meeting, Chicago, Illinois, 01/2018
Tanhehco EJ, Cantrell DR, Palasis S, Pediatric Neurovascular Imaging Techniques: Choosing Wisely, Poster Presented at the American Society of Pediatric Neuroradiology 2nd Annual Meeting, Miami Beach, Florida, 01/2020
Wu Y, Adate A, Lalvani S, Iorga M, Cantrell DR, Zhang J, Szrama N, Badhe S, Naidech AM, Tanhehco E, Patel K, Hasan S, Parrish TB, Katsaggelos AK, Hill VB, Identification of Intracranial Hemorrhage and Its Subtypes on Head CT Scans Using Transfer Learning and Weakly Supervised Networks, Poster Presented at the American Society of Neuroradiology 2022 meeting, New York, New York, 05/2022
 

EXTRAMURAL TEACHING:
Medical Student Education
2012 University of Illinois College of Medicine, Mentor’s Program (Endocrinology)
2012 - 2014 University of Illinois College of Medicine, Pediatrics Career Development Track (CADET) Program
2012 - 2014 University of Illinois College of Medicine, Student Education Team (SET)
2013 - 2015 MediPal Pen Pals
 

PROFESSIONAL EXPERIENCE:
1994 - 1995 University of Michigan Medical School Ann Arbor, MI • Laboratory Assistant
1995 University of Michigan Hospital Trauma Burn Center • Laboratory Technician
2000 - 2001 Brigham & Women’s Hospital Boston, MA • Post-doctoral Fellow - Modulation of Tcell migration in the setting of myocarditis
2001 - 2004 Henry Ford Health System Detroit, MI • Assistant Research Investigator - Pathogenesis and treatment of heart failure
2003 - 2010 CorDynamics, Inc. Chicago, IL • Chief Scientific Officer, Co-Founder, and Co-Owner - Contract laboratory focusing on cardiovascular toxicology
2009 - 2013 Laboratory Style Initiative, LLC Chicago, IL • Founder and Sole Proprietor - Design, production and retail distribution of premium lab coats. - ELISA style lab coat design featured in the movie “RoboCop” (2014)


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Chi L, Park JL, Friedrichs GS, Banglawala YA, Perez MA, Tanhehco EJ, Lucchesi BR. Effects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart. Br J Pharmacol. 117:1261-1269, 1996.
2. Gralinski MR, Chi L, Park JL, Friedrichs GS, Tanhehco EJ, McCormack JG, Lucchesi BR. Protective effects of ranolazine on ventricular fibrillation induced by activation of the ATP-dependent potassium channel in the rabbit heart. J Cardiovasc Pharmacol Therapeut. 1:141-148, 1996.
3. Park JL, Tanhehco EJ, Kilgore KS, Gralinski MR, Lucchesi BR. Reviparin-sodium prevents complement-mediated myocardial injury in the isolated rabbit heart. J Cardiovasc Pharm. 30:658-666, 1997.
4. Kilgore KS, Park JL, Tanhehco EJ, Booth EA, Marks RM, Lucchesi BR. Attenuation of interleukin-8 expression in C6-deficient rabbits following myocardial ischemia/reperfusion. J Mol Cell Cardiol. 30:87-95, 1998.
5. Kilgore KS, Tanhehco EJ, Park JL Naylor KB, Anderson MB, Lucchesi BR. Reduction of myocardial infarct size by glucoronic acid-containing glycosides in vivo. J Pharmacol Exp Therapeut. 284:427-435, 1998.
6. Kilgore KS, Naylor KB, Tanhehco EJ, Park JL, Lucchesi BR. The semi-synthetic polysaccharide pentosan polysulfate prevents complement mediated injury in the rabbit perfused heart. J Pharmacol Exp Therapeut. 285:987-994, 1998.
7. Tanhehco EJ, Kilgore KS, Naylor KB, Park JL, Booth EA, Lucchesi BR. Reduction of myocardial infarct size after ischemia and reperfusion by the glycosaminoglycan pentosan polysulfate. J Cardiovasc Pharmacol. 34:153-161, 1999.
8. Tanhehco EJ, Kilgore KS, Liff DA, Murphy KL, Fung MS, Sun WN, Sun C, Lucchesi BR. The anti-factor D antibody, MAb 166-32, inhibits the alternative pathway of the human complement system. Trans Proc. 31:2168-2171, 1999.
9. Kilgore KS, Tanhehco EJ, Naylor KB, Lucchesi BR. Ex vivo reversal of heparinmediated cardioprotection by heparinase after ischemia and reperfusion. J Pharmacol Exp Therapeut. 290:1041-1047, 1999.
10. Tanhehco EJ, Yasojima K, McGeer PL, Washington RA, Kilgore KS, Homeister JW, Lucchesi BR. Preconditioning reduces tissue complement gene expression in the rabbit isolated heart. Am J Physiol. 277:H2373-H2380, 1999.
11. Tanhehco EJ, Yasojima K, McGeer PL, Lucchesi BR. Acute cocaine exposure upregulates complement expression in the rabbit heart. J Pharmacol Exp. Therapeut. 292:201-208, 2000.
12. Tanhehco EJ, Yasojima K, McGeer PL, Washington RA, Lucchesi BR. Free radicals upregulate complement expression in the rabbit isolated heart. Am J Physiol. 279:H195-H201, 2000.
13. Tanhehco EJ, Yasojima K, McGeer PL, McGeer EG, Lucchesi BR. Preconditioning reduces tissue complement gene expression in vivo. Am J Physiol. 279:H1157-H1165, 2000.
14. Tanhehco EJ, Lucchesi BR. Therapeutic potential of complement inhibitors in myocardial ischemia. Expert Opin Invest Drugs. 9:975-991, 2000.
15. Tanhehco EJ, Lee H, Lucchesi BR. Sublytic complement attack reduces infarct size in the rabbit isolated heart: evidence for C5a mediated protection. Immunopharm. 49:391-399, 2000.
16. Tanhehco EJ. Potassium channel modulators as anti-inflammatory agents. Expert Opin Therapeut Patents. 11:1137-1145, 2001.
17. Sharov VG, Todor A, Suzuki G, Morita H, Tanhehco EJ, Sabbah HN. Hypoxia, angiotensin II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role of p38 MAPK, Fas-L and cyclin D1. Eur J Heart Failure. 5:121-129, 2003.
18. Suzuki G, Mishima T, Tanhehco EJ, Sharov VG, Todor A, Chaudhry PA, Anagnostopoulos PV, Nass O, Goldstein S, Sabbah HN. Effects of the AT1 – receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure. Brit J Pharmacol. 138:301-309, 2003.
19. Mishima T, Tanimura M, Suzuki G, Todor A, Sharov VG, Tanhehco EJ, Goldstein S, Sabbah HN. Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with heart failure. Cardiovascular Drugs and Therapy. 6:209-214, 2002.
20. Todor A, Sharov VG, Tanhehco EJ, Silverman N, Bernabei A, Sabbah HN. Hypoxia induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes. Am J Physiol. 283:H990-H995, 2002.
21. Suzuki G, Sharov VG, Morita H, Mishima T, Anagnostopoulos PV, Chaudhry PA, Nass O, Tanhehco EJ, Sabbah HN, Goldstein S. Effects of early long-term monotherapy with eplerenone, a novel aldosterone receptor antagonist, on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure. Circulation. 106:2967-2972, 2002.
22. Morita H, Suzuki G, Mishima T, Chaudhry PA, Anagnostopoulos PV, Tanhehco EJ, Sharov VG, Goldstein S, Sabbah HN. Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Cardiovasc Drugs Therap. 16:443-449, 2002.
23. Morita H, Suzuki G, Haddad W, Mika Y, Tanhehco EJ, Sharov VG, Goldstein S, BenHaim S, Sabbah HN. Cardiac contractility modulation with non-excitatory electric signals improves left ventricular ejection fraction in dogs with chronic heart failure. J Cardiac Failure. 9:69-75, 2003.
24. Sabbah HN, Sharov VG, Gupta RC, Mishra S, Rastogi S, Undrovinas AI, Chaudhry PA, Todor A, Mishima T, Tanhehco EJ, Suzuki G. Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventricular containment. Circ Res. 93:1095-1101, 2003.
25. Morita H, Suzuki G, Haddad E, Mika Y, Tanhehco EJ, Goldstein S, Ben-Haim S, Sabbah HN. Long-term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur J Heart Failure. 6:145-150, 2004.
26. Rastogi S, Gupta RC, Mishra S, Morita H, Tanhehco EJ, Sabbah HN. Long-term therapy with the Acorn cardiac support device normalizes gene expression of growth factors and gelatinases in dogs with heart failure. J Heart Lung Transplant. 24:1619-1625, 2005.
27. Kotalba D, Goldstein S, Khaja F, Rybicki BA, Sabbah HN, Tanhehco EJ. Norepinephrine level as a predictor of mortality after myocardial infarction. J Clin Basic Cardiol. 8:55-58, 2005.
28. Suzuki G, Khanal S, Rastogi S, Morita H, Mishima T, Anagnostopoulos PV, Nass O, Sharov V, Tanhehco EJ, Goldstein S, Sabbah HN. Long-term pharmacological activation of PPARgamma does not prevent left ventricular remodeling in dogs with advanced heart failure. Cardiovasc Drugs Ther. 21: 29-36, 2007.
29. Li J, Tanhehco E, Russell B. Actin dynamics is rapidly regulated by the PTEN increase of phosphatidylinositol 4,5 – bisphosphate (PIP2). Am J Physiol. 307:H1618-25, 2014.
30. Wu Y, Iorga M, Badhe S, Zhang J, Cantrell DR, Tanhehco EJ, Szrama N, Naidech AM, Drakopoulos M, Hasan ST, Patel KM, Hijaz TA, Russell EJ, Lalvani S, Adate A, Parrish TB, Katsaggelos AK, Hill VB. Precise Slice-level localization of intracranial hemorrhage on head CTs with networks trained on scan-level labels. Manuscript submitted for publication.
 
Books, Chapters, and Reviews
1. Sabbah HN, Tanhehco EJ. Animal models: apoptosis and oxidative stress. In: Oxidative stress and cardiac failure. Eds. Kukin ML and Fuster V. Futura Publishers. 2002.
2. Tanhehco EJ, Lucchesi BR. The role of complement in cardiac inflammation and reperfusion injury. In: Inflammation and cardiac diseases. Eds. Feuerstein GZ, Libby P, Mann DL. Springer Birkhauser. 2003.
3. Tanhehco EJ, Sabbah HN. The role of IL-6 in experimental and clinical heart failure In: Inflammation and cardiac diseases. Eds. Feuerstein GZ, Libby P, Mann DL. Springer Birkhauser. 2003.
4. Tanhehco EJ, Sabbah HN. Experimental models of remodeling. In: Cardiac remodeling: mechanisms and treatment. Ed. Greenberg B. Taylor & Francis. 2005.
5. Sabbah HN, Tanhehco EJ, Sharov VG, Brewer R, Silverman N. The Acorn Cardiac Support Device as a therapy for heart failure. In: Advanced Heart Failure Textbook. Eds. O’Connor CM, Gattis WA, Gheorghiade M, Adama KF. London and New York, 2005.
 
Abstracts
1. Chi L, Friedrichs GS, Park JL, Banglawala YA, Perez MA, Tanhehco EJ, Lan K-L, Lucchesi BR. Effects of tedisamil (KC-8857) on electrophysiology, ventricular fibrillation (VF) and cardiac function in vitro. FASEB J. 9:A605, 1995.
2. Lucchesi BR, Park JL, Friedrichs GS, Chi L, Banglawala YA, Perez MA, Tanhehco EJ. Effects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart. Eur J Cardiac Pacing Electrophysiol. 6(Suppl 5): 29, 1996.
3. Kilgore KS, Park JL, Tanhehco EJ, Booth EA, Marks RM, Lucchesi BR. Attenuation of interleukin-8 expression in C6-deficient rabbits following myocardial ischemia/reperfusion. J Mol Cell Cardiol. 29:A207, 1997.
4. Tanhehco EJ, Kilgore KS, Naylor KB, Lucchesi BR. Ex vivo reversal of heparinmediated cardioprotection in C6-deficient rabbits following myocardial ischemia/reperfusion. FASEB J. 12:A33, 1998.
5. Kilgore KS, Tanhehco EJ, Naylor KB, Park JL, Booth EA, Lucchesi BR. Reduction of myocardial infarct size after ischemia and reperfusion by the glycosaminoglycan pentosan polysulfate. J Mol Cell Cardiol. 30:A238, 1998.
6. Tanhehco EJ, Kilgore KS, Naylor KB, Park JL, Booth EA, Lucchesi BR. Reduction of myocardial infarct size after ischemia and reperfusion by the glycosaminoglycan pentosan polysulfate. FASEB J. 13:A21, 1999.
7. Tanhehco EJ, Yasojima K, McGeer PL. Kilgore KS, Lucchesi BR. Preconditioning reduces tissue complement gene expression in the rabbit isolated heart. FASEB J. 13:A20, 1999.
8. Tanhehco EJ, Rudolph AE, Suzuki G, Morita H, Sharov VG, Todor A, McMahon EG, Goldstein S, Sabbah HN. The aldosterone receptor antagonist, eplerenone, decreases gelatinase activity in dogs with chronic heart failure. American Heart Association Scientific Sessions, Abstract ID 103467, 2002.
9. Tanhehco EJ, Rudolph AE, Suzuki G, Morita H, Sharov VG, Todor A, McMahon EG, Goldstein S, Sabbah HN. The aldosterone receptor antagonist, eplerenone, decreases gelatinase activity in dogs with chronic heart failure. European Society of Cardiology, 2002.