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CURRICULUM VITAE

George M. Hoffman MD
Chief, Professor
Department of Anesthesiology
Division of Clinical
Professor, Anesthesiology and Pediatrics
Medical Director and Chief, Pediatric Anesthesiology
Associate Medical Director and Chief, Pediatric Cardiac Critical Care

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226
Phone: 414-266-3560
Fax: 414-266-6092
Email: ghoffman@mcw.edu

EDUCATION:
1972 - 1976 A.B, cum laude, Harvard University, Cambridge, MA
1976 - 1980 M.D., University of Pennsylvania School of Medicine, Philadelphia, PA

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
06/1980 - 06/1983 Intern, Junior, and Senior Resident, Pediatrics, Medicine, The Children's Hospital of Boston, Boston, MA
07/1983 - 06/1984 Chief Resident, Pediatrics, Medicine, The Children's Hospital of Boston, Boston, MA
07/1984 - 12/1984 Fellow, Pediatrics, Anesthesiology and Critical Care Medicine, The Children's Hospital of Boston, Boston, MA
01/1985 - 12/1986 Resident, Anesthesiology, Brigham and Women's Hospital, Boston, MA
01/1987 - 06/1987 Fellow, Pediatrics, Anesthesiology and Critical Care Medicine, The Children's Hospital of Boston, Boston, MA
10/2006 - 03/2007 Faculty Leadership Development Program Certificate, Lubar School of Management, University of Wisconsin, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
1980 - 1983 Clinical Fellow, Pediatrics, Harvard Medical School
1983 - 1984 Instructor, Pediatrics, Harvard Medical School
1984 - 1987 Clinical Fellow, Anesthesiology, Harvard Medical School
07/1987 - 1994 Assistant Professor, Anesthesiology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI
07/1994 - 2005 Associate Professor, Anesthesiology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI
07/2005 - Present Professor, Anesthesiology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI
07/2012 - Present Professor, Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
06/1994 - Present Division Chief, Anesthesiology, Pediatric, Medical College of Wisconsin, Milwaukee, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
1983 - 1987 Physician Coordinator, MICU Transport Team, Children's Hospital, Boston, MA
07/1989 - 04/1994 Assistant Medical Director, Anesthesiology, Pediatric Anesthesiology, Children's Hospital of Wisocnsin, Milwaukee, WI
06/1994 - Present Medical Director and Chief of Pediatric Anesthesia, Anesthesiology, Pediatric Anesthesiology and Critical Care, Children's Hospital /Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226
03/1995 - 03/2002 Vice Chief, Surgery, Children's Hospital of Wisconsin, Milwaukee, WI
01/1998 - Present Biomedical Equipment Liaison, Departments of Anesthesiology and Clinical Engineering, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, MS 681, Wauwatosa, WI 53226
01/1998 - 12/2012 Anesthesia Medical Director, Liver Transplant Program, Anesthesiology, Pediattric Anesthesiology and Critical Care, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, MS 681, Wauwatosa, WI 53226
07/1998 - 12/2012 Quality Assurance Director, Department of Anesthesiology, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, MS 681, Wauwatosa, WI 53226
01/2016 - Present Director of Pediatric Cardiac Critical Care, Pediatric Anesthesiology and Critical Care, Children's Hospital / Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226

HOSPITAL STAFF PRIVILEGES:
07/1987 - 07/1990 Courtesy Staff, Pediatrics, Anesthesiology and Critical Care Medicine, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
07/1987 - Present Associate Director, Pediatrics, Critical Care, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
04/1989 - 04/1994 Assistant Director, Pediatrics, Anesthesiology, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
07/1990 - Present Active Staff, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
06/1994 - Present Chief, Pediatrics, Anesthesiology, Medical College of Wisconsin, Milwaukee, WI
06/1994 - Present Medical Director, Pediatrics, Anesthesiology, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
03/1995 - 03/2002 Vice Chief, Pediatrics, Surgery, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226
01/2016 - Present Acting Director, Pediatrics, Critical Care Cardiac Intensive Care, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Wauwatosa, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
National Board of Medical Examiners
06/1981
None
Lifetime Certificate
06/1984
None
Lifetime Certificate
04/1990
None
Critical Care Medicine
1990
1998
Critical Care Medicine
1998
2004
Critical Care Medicine
2005
2012
Anesthesiology-Voluntary Recertifcation
2009
2023
Critical Care Medicine-Meeting MOC
2012
2022
Pediatric Anesthesiology
2013
2023
 
Certificates
Issued By Issue DateExpiration
Advanced Cardiac Life Support Provider
American Heart Association
06/2019
06/2021
Pediatric Advanced Life Support Provider
American Heart Association
05/2020
05/2022
 

Licensure
Number Issue DateExpiration
Commonwealth of Massachusetts
53647
09/1984
None
State of Wisconsin
0028371-020
06/1987
None
 

AWARDS AND HONORS:
06/1988 Teaching Award,Department of Anesthesiology, Medical College of Wisconsin
06/1989 Honorary Pediatrician,Teaching Award, Department of Pediatrics, Medical College of Wisconsin
06/1990 Teaching Award,Department of Anesthesiology, Medical College of Wisconsin
06/1995 Honorary Pediatrician,Teaching Award, Department of Pediatrics, Medical College of Wisconsin
03/1996 Citation, The Best Doctors in America, Midwest Edition
10/1998 Citation, The Best Doctors in America, 4th Edition
01/2001 Citation, Strathmore's Who's Who
12/2001 Citation, The Best Doctors in America, 7th Edition
05/2003 Citation, Guide To America's Top Physicians 2003-2004, Consumer Research Council of America
12/2004 Citation, Guide To America's Top Pediatricians 2004-2005, Consumer Research Council of America
10/2005 Listing, The Best Doctors in America, Best Doctors Inc.
12/2005 Citation, Guide To America's Top Pediatricians 2006 Edition, Consumer Research Council of America
10/2006 Listing, The Best Doctors in America, Best Doctors Inc.
10/2007 Listing, The Best Doctors in America, Best Doctors Inc.
10/2008 Listing, The Best Doctors in America, Best Doctors Inc.
10/2009 Listing, The Best Doctors in America, Best Doctors Inc.
10/2010 Listing, The Best Doctors in America, Best Doctors Inc.
01/2012 Listing, The Best Doctors in America, Best Doctors Inc.
01/2013 Listing, The Best Doctors in America, Best Doctors Inc.
01/2014 Listing, The Best Doctors in America, Best Doctors Inc.
04/2014 Recipient, Cardiovascular in the Young Award for clinical and academic mentorship, American Heart Association CVDY Visiting Professor
01/2015 Listing, The Best Doctors in America, Best Doctors Inc.
01/2016 Listing, The Best Doctors in America, Best Doctors Inc.
01/2017 Listing, The Best Doctors in America, Best Doctors Inc.
01/2018 Listing, The Best Doctors in America, Best Doctors Inc.
01/2019 Listing, The Best Doctors in America, Best Doctors Inc.
01/2020 Listing, The Best Doctors in America, Best Doctors Inc.

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
01/1984 - Present Massachusetts Medical Association (Member)
01/1985 - Present American Society of Anesthesiologists (Member)
05/1985 - Present American Academy of Pediatrics (Fellow)
01/1987 - Present International Anesthesia Research Society (Member)
10/1987 - Present Society for Pediatric Anesthesia (Member)
04/1989 - Present Society of Cardiovascular Anesthesiologists (Member)
12/1990 - Present Society of Critical Care Medicine (Member)
12/1991 - Present Society for Technology in Anesthesia (Member)
12/2005 - Present Congenital Cardiac Anesthesia Society (Member)
05/2006 - Present Association of University Anesthetists (Member)
09/2009 - Present Cardiovascular Medicine in Anesthesia: Basic Science, Faculty of 1000 Medicine (Faculty)
01/2015 - Present Society of Thoracic Surgeons (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Ad-Hoc Reviewer
1994 - Present Anesthesia and Analgesia
1994 - Present Intensive Care Medicine
1996 - Present American Journal of Respiratory and Critical Care Medicine
2000 - Present Journal of Thoracic and Cardiovascular Surgery
2000 - Present Annals of Thoracic Surgery
2002 - Present Circulation
2007 - Present Pediatric Anesthesiology
2007 - Present European Journal of Cardiothoracic Surgery
2008 - Present European Journal of Anaesthesiology
2008 - Present Anesthesiology
2008 - Present Pediatrics
2014 - Present PLOS one
2018 - Present BMC Anesthesiology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1994 - Present Member, Study Group in Pediatric Anesthesia, Pediatric Anesthesia Leadership Group
1997 - 1998 Member, Perioperative Services Improvement Group, National Association for Children's Hospitals (NACHRI)
05/2001 Consultant, Pediatric Cardiac Surgery Program Review Committee, Children's Health System, St. Paul MN
12/2005 - 12/2006 Member, Committee for ACGME Recommedations for Pediatric Cardiac Anesthesia Curriculum, Congenital Cardiac Anesthesia Society
01/2009 - 10/2010 Member, International Liaison Committee on Resuscitation and American Heart Association ECC Pediatric Committee and PCICS Leadership Task Force for Resuscitation Guidelines Development in Congenital Heart Dis, American Heart Association and PCICS
04/2009 - 04/2014 Member, Clinical Trials Development Workgroup, NHLBI, Washington DC and Boston, MA, Pediatric Heart Network
04/2009 - 10/2010 Member, 2010 Scientific Meeting Program Planning Committee, Pediatric Cardiac Intensive Care Society
08/2009 - 12/2010 Worksheet Author, International Liaison Committee on Resuscitation for Resuscitation of the patient with a single ventricle, American Heart Association
10/2010 - 10/2011 Member, Writing Committee on Consensus Statements for Monitoring in Congenital Heart Disease, Pediatric Cardiac Intensive Care Society
05/2012 - Present Member, Research Steering Committee, Pediatric Cardiac NeuroDevelopmental Symposium collaborative outcome group
06/2012 - Present Member, American Heart Association Writing Committee, Consensus Statement on Cardiopulmonary Resuscitation in Infants and Children with Congenital Heart Disease, American Heart Association
03/2014 - 06/2015 Member, 2015 Scientific Symposium Program Planning Committee, Cardiac NeuroDevelopmental Study Collaborative
09/2014 Consultant, Pediatric Cardiac Sciences / Anesthesia / Critical Care Program Review, Izaak Walton Killam IWK Health Center, and Dalhousie University, Halifax, NS
06/2015 Consultant, Pediatric Cardiac Surgery Program Review, University of Minnesota / Masonic Children’s Hospital, Minneapolis, MN
09/2015 - Present Member, Research Steering Committee, Pediatric Cardiac Intensive Care Society
09/2017 - Present Member, Neurodevelopmental Outcome Research Committee, Pediatric Heart Network
01/2018 - Present Consultant, Pediatric Heart Network research steering committee, NIH
01/2018 - Present Member, Surgical/Perioperative Learning Lab Committee, National Pediatric Cardiology - Quality Improvement Collaborative
01/2018 - Present Member, Research Steering Committee, Cardiac Neurodevelopmental Outcomes Collaborative
01/2018 - Present Member, Writing Committee, Cardiac Neurodevelopmental Outcomes Collaborative R13/R01 grant submission
05/2018 - 07/2018 Consultant, Pediatric Cardiac Program Review and Planning Committee, Norton Children's Hospital and University of Louisville KY
08/2018 - Present Member, Surgical/Perioperative outcome collaborative, Evelina London Children's Hospital /Guy's and St Thomas' NHS Foundation Trust / Children's Hospital of Wisconsin

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Neonatal hemodynamics short and long term outcome data bank
Source:
Children's Hospital of Wisconsin and Medical College of Wisconsin
Role:
Principal Investigator
Dates:
1998 - Present
 
Title:
Use Of Parenteral Phenoxbenzamine In Infants And Children During Surgery For Congenital Heart Disease. CHW and internal.
Role:
Senior investigator
Dates:
1999 - Present
 
Title:
Phentolamine for control of systemic vascular resistance after cardiac surgery: Hemodynamic response and outcomes assessment, internal
Role:
Senior investigator,
Dates:
2013 - Present
 
Title:
FP00008729 Brain Connectome and Neurodevelopment Outcomes
Source:
NIH
Dates:
04/2016 - 04/2021
Direct Funds:
$172,196
 
Title:
Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes. Pediatric Heart Network/NHLBI. FP00011023. SVRIII: Brain Connectome and Neurodevelopment Outcomes (budget based). Brain Connectome and Neurodevelopment Outcomes
Source:
NIH
Role:
site PI
PI:
Hoffman, George
Dates:
2016 - Present
Direct Funds:
$18,835 (Approval number 825480-6, FP00008729.)
 
Title:
Patterns of agreement and correlation of regional oxygen measures (internal)
Role:
primary investigator
PI:
Hoffman, George
Dates:
2017 - Present
 
Title:
Use of Arginine Vasopressin in Early Postoperative Management After Fontan Palliation RCT
Source:
CTSI and internal
Role:
Senior Investigator,
Dates:
2017 - 2020
Direct Funds:
$25,000 (Approval number 885148-7 )
 
Title:
Dual aortic perfusion cardiopulmonary bypass strategy for Norwood palliation of hypoplastic left heart syndrome: retrospective review of relationship between perioperative physiologic indices and organ function, and outcome comparison to single antegrade perfusion technique (internal)
Role:
primary investigator
PI:
Hoffman, George
Dates:
2017 - Present
 
Title:
Total Cell-Free Deoxyribonucleic Acid (tcf-DNA) as a Predictor of Severity of Illness and Outcome Following Pediatric Cardiac Surgery,
Source:
CTSI and AHWl
Role:
supporting investigator
Dates:
2018 - Present
Direct Funds:
$50,000 (Approval number 1178044, . FP00012825)
 
Title:
Observer-blinded randomized study of propofol infusion vs bolus dexmedetomidine and propofol sedation for pediatric magnetic resonance imaging
Role:
Senior investigator
Dates:
2018 - 2020
 
Title:
Optimizing Cardiopulmonary Bypass to Support Cerebral and Somatic Perfusion during Aortic Arch Reconstruction.
Source:
CTSI, CRI, WeCare
Role:
senior investigator, co-PI
PI:
Hoffman, George
Dates:
2018 - Present
Direct Funds:
$78,974 (Approval number FP00012522.)
 
Title:
FP00011023 SVRIII: Brain Connectome and Neurodevelopment Outcomes-budget based
Source:
NIH
Role:
Site PI
Direct Funds:
$15,525
 
Title:
PHN Dexmedetomidine Neuroprotection in Infant Cardiac Surgery: A Neuroimaging-based Mechanistic Study (multicenter study in submission). funding amount uncertain
Source:
NIH
Direct Funds:
$1
 
Prior
Peer Review
Title:
Non-volumetric methodology for metabolic measurements; Effect of substrate availability and stress on respiratory quotient
Source:
Equipment grant from Ohmeda, Inc
Role:
Principal Investigator
Dates:
1991 - 1993
 
Title:
Dynamic analysis of factors in anesthesia circuit and ventilator design in the production of expiratory flow limitation
Source:
Equipment grant from Ohmeda, Inc
Role:
Principal Investigator
Dates:
1992 - 1993
 
Title:
Pediatric Cardiac Arrest and Death Registry
Source:
American Academy of Pediatrics Section on Anesthesiology
Role:
Site PI
Dates:
1992 - 1998
 
Title:
Inhaled Nitric Oxide for Selective Pulmonary Vasodilation, CHW/MCW
Source:
Ohmeda, Inc and Children's Hospital Foundation
Role:
Principal Clinical Investigator
Dates:
1993 - 1999
Direct Funds:
$70,000 ($30,000 Equipment grant from Ohmeda, Inc and $40,000 Equipment and Operations grant from Children's Hospital Foundation)
 
Title:
Characterization of abnormalities in gas exchange by the quantitative analysis of alveolar gas domains
Source:
Equipment grant from Ohmeda, Inc
Role:
Principal Investigator
Dates:
1993 - 1996
 
Title:
Development of risk indices and outcome measures in for pediatric anesthesia
Role:
Consultant to Study Group in Pediatric Anesthesia
Dates:
1995 - 1999
 
Title:
Prediction of Lactate from Strong Ion analysis
Source:
Children’s Hospital Foundation
Role:
Senior Investigator
Dates:
1997 - 1998
 
Title:
Human engineering and alarm recognition factors to improve utility of capnography
Source:
Equipment grant from Ohmeda, Inc
Role:
Principal Investigator
Dates:
1998 - 1999
 
Title:
Assent of Children undergoing Surgery
Source:
Children’s Hospital Foundation
Role:
Senior Investigator
Dates:
2003 - 2004
 
Title:
Cerebral outcome in hypoplastic left heart syndrome
Source:
Children’s Hospital Foundation
Role:
Senior Investigator
Dates:
2005 - 2013
 
Title:
Animal model for NIRS detection of regional blood flow
Source:
Somanetics, Inc
Role:
Clinical Advisor-Investigator
Dates:
2007 - 2008
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Practice variation in the Norwood Perioperative Period SVO2, NIRS & inotropes, **New** presentation to another department (Surgery, Urology, etc.), 08/14/2018
Oximetric and Pressure measures for hemodyanamic assessment- with expansion to per-stroke parameters, **New** presentation to another department (Surgery, Urology, etc.), 10/02/2018
Patient And System Factors Affecting Anesthesiologist First Case Start Performance., Grand Rounds, Department of Anesthesiology, Milwaukee, WI, 11/2019
SvO2 and NIRS - part 3, **Repeat** lecture for residents
SvO2 and NIRS - part 2, **Repeat** lecture for residents
SvO2 and NIRS - part 1, **Repeat** lecture for residents
Oxygen Transport and Economy, **Repeat** lecture for residents
Alveolar Gas and V/Q, **Repeat** lecture for residents
Professor Rounds for Pediatric Fellows, Departmental Lecture (Friday Conference, M & M, CSG Grand Rounds, etc.)
Pedaitric Anesthesia Outcomes, **Repeat** presentation to another department (Surgery Grand Rounds, etc.)
 
Regional
Assessment of Extubation Readiness (by invitation), MCW/CHW PICU Regional Conference, Milwaukee, WI, 05/2019
Decoding the Circulation using Ohm's Law and Fick's Principle (by invitation), Marshfield Clinic Pediatric Rounds, Marshfield, WI, 07/2019
Application of multimodal bedside monitoring to identify risk and monitor interventions in meaningful ways (by invitation), Cardiac ICU Visiting Professor, Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, 11/2019
Non-invasive hemodynamic monitoring in congenital cardiac disease (lecture); Goal-directed hemodynamic intervention in hypoplastic left heart syndrome (lecture), Visiting Professor, Cincinnati Children’s Medical Center, Cincinatti, OH, 04/2020
 
National
Attaining ACS Level 1 Verification. Session Leader (by invitation) Pediatric Anesthesia Leadership Colloquium, Chicago, IL, 11/2018
CHW Experience with High-Density Data (by invitation), Guiding Patient Care Summit, Boston, MA, 09/2019
 
International
Optimal practice to prevent recognize and manage complications related to devices and invasive monitoring in critically ill children; HFOV: Is it time to move on after almost 50 years?; The ideal fluid for resuscitation in chi, European Postgraduate Course in Neonatal and Pediatric Intensive Care 13th Annual. Visiting Professor, Children's Hospital and University of Bern, Bern, Switzerland, 03/2019
Practice Variation in HLHS: NIRS and Inotropes (by invitation)., National Pediatric Cardiology Quality Improvement Collaborative, 6th Scientifc Meeting of the World Society of Pediatric and Congenital Heart Surgery, Orlando, FL, 07/27/2019
Anesthesia and Intensive Care Consideration for Borderline Left Ventricle (by invitation). 2nd Annual Heart Summit, Herma Heart Institute, Milwaukee, WI., Other National / International Society Lecture, 10/10/2019
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
National
Tanem J, Simon JA, Scott JP, Berens RJ, Hoffman GM., Anesthesia Associated Cardiac Arrest: A Single Center Experience. A1063., Scientific Session of the Annual Meeting of the American Society of Anesthesiologists, Orlando, FL, 10/2019
Taylor SP, Berens RJ, Hoffman GM., Perioperative Ketorolac Administration Increases Post-tonsillectomy Bleeding in a Tertiary Pediatric Hospital; a Quality Review F2087, Featured Abstract Scientific Session of the Annual Meeting of the American Society of Anesthesiologists, Orlando, FL, 10/2019
Taylor SP, Berens RJ, Hoffman GM., Perioperative Ketorolac Administration Increases Post-tonsillectomy Bleeding in a Tertiary Pediatric Hospital; a Quality Review. Featured Abstract F2087., Scientific Session of the Annual Meeting of the American Society of Anesthesiologists, Orlanda, FL, 10/2019
Hoffman GM, Scott JP, Berens RJ., , Patient and System Factors Affecting Anesthesiologist First Case Start Performance F2095., Featured Abstract Scientific Session of the Annual Meeting of the American Society of Anesthesiologists, Orlando, FL, 10/2019
Hoffman GM, Scott JP, Berens RJ, Patient and System Factors Affecting Anesthesiologist First Case Start Performance. A1098., Scientific Session of the Annual Meeting of the American Society of Anesthesiologists, Orlando, FL, 10/2019
Tanem-J, Scott-J, Stamm-K, Niebler-R, Hoffman-G, Bertrandt-R, Otto-M, Simpson-P, North-P, Wood-R, Hraska-V, Mitchell-M., Peak Total Cell-free DNA Predicts Death And Adverse Events Following Pediatric Cardiothoracic Surgery., Western Thoracic Society 46th Annual Meeting, Virtual, Vail, CO, 06/2020
 
International
Hoffman-GM, Niebler-RA, Scott-JP, Bertrandt-RA, Ghanayem-NS, Thompson-NA, Stuth-EA, Woods=RA, Mitchell-ME, Hraska-V, Mussatto-KA, Tweddell-JS., Interventions Associated with Successful Treatment of Low Cardiac Output following Norwood Procedure, 56th annual meeting of the Society of Thoracic Surgeons, New Orleans, LA, 01/2020
 

COMMITTEE SERVICE:
Medical College of Wisconsin
05/1990 - Present Member, Executive Committee, Anesthesiology, Medical College of Wisconsin
05/1990 - Present Member, Critical Care Committee, Pediatrics, Department of Anesthesiology, Medical College of Wisconsin
05/1990 - Present Member, Curriculum and Clinical Competency Committee, Anesthesiology, Medical College of Wisconsin
01/1995 - 01/1998 Member, Clinical Practice Group Board, Medical College of Wisconsin
01/1995 - 01/1996 Member, Pediatric Physician-Hospital Organization Study Group, Pediatrics, Medical College of Wisconsin
11/1995 - 11/1997 Member, Billing and Collection Subcommittee, Clinical Practice Group, Medical College of Wisconsin
07/1996 - 07/1997 Member, Substance Abuse Prevention Committee, Anesthesiology, Medical College of Wisconsin
08/1996 - 12/1997 Chair, Pediatric Specialty Group Organization Committee, Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin
01/1998 - 01/2011 Member, Children’s Specialty Group (CSG) Executive Committee, Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin
01/1998 - 01/2008 Co-Chairr, CSG Finance Commitee, Medical College of Wisconsin
01/1998 - 01/2008 Co-Chair, Children’s Specialty Group (CSG) Finance Committee, Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin
01/2010 - Present Member, Children’s Specialty Group (CSG) Finance Committee, Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin
01/2010 - Present Member, MCW/CHW/CSG Clinical Planning Executive Group, Anesthesiology, Medical College of Wisconsin
07/2012 - Present Member, Pediatric Anesthesilogy Fellowship Clinical Competency Committee, Pediatrics, Anesthesiology, Medical College of Wisconsin
01/2016 - Present Member, MCW Compensation Review Committee, Medical College of Wisconsin
01/2018 - 09/2019 Member, Opthalmoloigy Chair Search Committee, Medical Collee of Wisconsin
 
Hospital
07/1987 - 07/1992 Member, Codes and Resuscitation Committee, Pediatrics, Children's Hospital of Wisconsin
01/1988 - 01/1992 Member, Trauma Core Committee, Pediatrics, Children's Hospital of Wisconsin
01/1988 - Present Member, Critical Care Committee, Pediatrics, Children's Hospital of Wisconsin
07/1988 - Present Member, Operating Room Committee, Pediatrics, Children's Hospital of Wisconsin
07/1989 - 07/1999 Member, Acute and Chronic Pain Service, Pediatrics, Anesthesiology, Children's Hospital of Wisconsin
06/1990 - 06/1991 Member, Congenital Diaphragmatic Hernia Task Force, Pediatrics, Children's Hospital of Wisconsin
06/1991 - Present Member, Cardiac Transplant Team, Pediatrics, Children's Hospital of Wisconsin
09/1991 - 11/1992 Member, Sedation Task Force, Pediatrics, Children's Hospital of Wisconsin
01/1992 - Present Member, Executive Committee, Pediatrics, Children's Hospital of Wisconsin
01/1993 - 01/1994 Member, Surgical Marketing/Long-Term Planning Task Force, Pediatrics, Children's Hospital of Wisconsin
07/1993 - Present Member, Blood Usage Committee, Pediatrics, Children's Hospital of Wisconsin
03/1994 - 03/2019 Member, CHW Executivee Committee, Children's Hosital of WisconsinMedical College of Wisconsin
06/1994 - Present Chair, CHW Pediatric Anesthesia Serivce Meeting, Medical College of Wisconsin
07/1994 - Present Member, CHW OR Commitee, Children's Hosital of Wisconsin
03/1995 - Present Member, Operating Room Executive Committee, Pediatrics, Children's Hospital of Wisconsin
03/1995 - Present Member, Surgical Patient Care Committee, Pediatrics, Children's Hospital of Wisconsin
03/1995 - 03/2002 Member, Quality Improvement Board, Pediatrics, Children's Hospital of Wisconsin
07/1997 - Present Chair, Sedation Committee, Pediatrics, Children's Hospital of Wisconsin
08/1998 - Present Member, Capital Equipment Planning Committee, Pediatrics, Children's Hospital of Wisconsin
12/2008 - Present Member, Wisconsin Hospital Association Outcomes Assessment Development Project, Pediatrics, Children's Hospital of Wisconsin
07/2009 - Present Member, Herma Heart Center Executive Committee, Pediatrics, Children's Hospital of Wisconsin
01/2011 - Present Member, Fetal Surgery Clinical and Planning Team, Pediatrics, Children's Hospital of Wisconsin
07/2011 - Present Member, iStrategy Provider Core Group, Pediatrics, Children's Hospital of Wisconsin
07/2011 - Present Team Lead, Anesthesia EPIC Advisory Committee, Pediatrics, Children's Hospital of Wisconsin
03/2012 - Present Member, CHW Medical Leadership Commitee, Children's Hosital of Wisconsin
06/2012 - Present Member, CHW Anesthesia Epic Advisory Committee, Children's Hosital of Wisconsin
07/2012 - Present Member, CHW OR Executive Committee, Children's Hosital of Wisconsin
01/2014 - Present Member, International Patient Program, Pediatrics, Children's Hospital of Wisconsin
07/2014 - Present Member, CHW Surgical Quality Improvement Commitee, Children's Hosital of Wisconsin
01/2015 - Present Member, CHW/HHI Cardiac Planning Meeting, Herma HEart Institute, Children's Hosital of Wisconsin
01/2016 - Present Chair, CHW CICU QI/Research Division meeting, Children's Hospital of Wisconsin
01/2016 - Present Member, CHW/HHI Executive Committee, Herma HEart Institute, Children's Hosital of Wisconsin
01/2016 - Present Co-Chair, HHI CICU QI / Case Review Committee, Herma Heart Institute, Children's Hosital of Wisconsin
07/2017 - Present Member, CHW Critical Care Executive Committee, Children's Hosital of Wisconsin
07/2018 - Present Member, CHW MCIP Steering Committee, Children's Hosital of Wisconsin
07/2018 - Present Member, CHW MCIP Patient Flow Committee, Children's Hosital of Wisconsin
07/2019 - Present Member, CHW/CSG Service In-Chief Committee, Children's Hosital of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Resident and Fellow Education
1987 - Present 2-4 didactic lectures per month to anesthesiology residents and fellows
1987 - Present 3-5 days per week bedside / operating room clinical teaching
1987 - Present 2-3 didactic lectures per month to pediatric and anesthesia residents and fellows in PICU
1991 - 2015 Block Coordinator for Physical Principles Core Curriculum, Department of Anesthesiology
1994 - 2015 Block coordinator for Pediatric Anesthesia, Department of Anesthesiololgy
07/2016 - Present Early Recognition and Goal-Directed Treatment of Shock. Pediatric Surgery- Anesthesia-Critical Care Block Curriculum, CHW/MCW
07/2016 - Present Pulmonary gas exchange: from inspired to alveolar gas (repeat 4-6x/year to anesthesia/critical care residents and fellows)
07/2016 - Present Bedside measures: physical principles and practical points. Anesthesia/ICU Fellow Block Curriculum, CHW/MCW
07/2017 - Present NIRS 101, 102, 103, 104 105: Circulatory physiology, principles of measurement, interpretation of data, use, misuse, and pitfalls, regional blood flow, neuroprotection. Anesthesia/ICU Fellow Block Curriculum, CHW/MCW
06/2018 - Present Cerebral hemodynamics, NIRS, and the lower limit of autoregulation. Anesthesia / Critical Care block lecture, MCW/CHW.
 

EXTRAMURAL TEACHING:
Resident and Fellow Education
1991 - 2008 Children's Hospital of Wisconsin Department of Anesthesiology, Weekly case conference moderated with planned presentation format, case analysis, literature review, and discussion
05/2018 - Present Medical College of Wiscosnin, Biochemistry, Electrolytes, Organ Dysfunction, and Shock: Physical-Chemical Approach to Acid-Base and Electrolytes to differentiate life-threatening from benign disturbances (Fencl-Stewart Acid-base Analysis). Pediatric Surgery- Anesthesia-Critical Care Block Curriculum, CHW/MCW
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Clinical/Research Fellows
Justinn Tanem, Medical College of Wisconsin, 07/2016 - Present clinical aadn research mentorship, abstract presentations, manuscript sumissions, excellence in fellowship, acceptance as academic faculty
 
Residents
Jacqueline Simon, Medical College of Wisconsin, 07/2017 - Present Mentor / Faculty Advisor - Resident Scholarly Activity Project, Abstract submission and presentation at ASA; acceptance in subspecialty fellowship trianing
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Clinical/Research Fellows
Mubasheer Ahmed, Medical College of Wisconsin and Texas Childrens Hospital, 07/2015 - Present Clinical and research mentorship, excellence in fellowship, abstract and manuscript submissions
Amee Bigelow, Medical College of Wisconsin, Cincinatti Childrens Medical Center, 07/2016 - Present clinical and research mentorship, fellowuhip excellence, abstract presentaitn and manuscipt publication, acceptance as academic faculty
 

GLOBAL HEALTH ACTIVITIES:
05/2000 Volunteer teaching and clinical physician, anesthesiology and critical care, Eric Williams Medical Science Center and Mount Hope Hospital, Mt Hope, Trinidad, West Indies. Pediatric cardiac surgery mission, sponsored by Caribbean Heart Menders Association.
01/2010 Volunteer teaching and clinical physician, anesthesiology and critical care.Angkor Hospital for Children, Siem Reap, Cambodia. Pediatric cardiac surgery mission sponsored by Children’s Lifeline International.
01/2011 Volunteer teaching and clinical physician, anesthesiology and critical care.Angkor Hospital for Children, Siem Reap, Cambodia. Pediatric cardiac surgery mission sponsored by Children’s Lifeline International.
10/2011 Volunteer teaching and lcinical physician (by invitation), anesthesiology and critical care.Hospital of the Clinical Faculty of Medicine of Ribeirão Preto USP – Campus, Sao Paulo, Brazil.
01/2012 Volunteer teaching and clinical physician, anesthesiology and critical care.Angkor Hospital for Children, Siem Reap, Cambodia. Pediatric cardiac surgery mission sponsored by Children’s Lifeline International.
01/2013 Volunteer teaching and clinical physician, anesthesiology and critical care.Angkor Hospital for Children, Siem Reap, Cambodia. Pediatric cardiac surgery mission sponsored by Children’s Lifeline International.
01/2014 Volunteer teaching and clinical physician, anesthesiology and critical care.Angkor Hospital for Children, Siem Reap, Cambodia. Pediatric cardiac surgery mission sponsored by Children’s Lifeline International.
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Coates PM, Cortner JA, Hoffman GM, Brown SA. Acid lipase activity of human lymphocytes. Biochim Biophys Acta. 1979 Feb 26;572(2):225-34.
2. McNeely JK, Hoffman GM, Eckert JE. Postoperative pain relief in children from the parascalene injection technique. Reg Anesth. 1991 Jan-Feb;16(1):20-2.
3. Losek JD, Hellmich TR, Hoffman GM. Diagnostic value of anemia, red blood cell morphology, and reticulocyte count for sickle cell disease. Ann Emerg Med. 1992 Aug;21(8):915-8.
4. Havens PL, Wendelberger KJ, Hoffman GM, Lee MB, Chusid MJ. Corticosteroids as adjunctive therapy in bacterial meningitis. A meta-analysis of clinical trials. Am J Dis Child. 1989 Sep;143(9):1051-5.
5. Havens PL, Hoffman GM, Shith KJ. The homogeneous nature of the hemolytic uremic syndrome. Clin Pediatr (Phila). 1989 Oct;28(10):482-3.
6. Havens PL, Splaingard ML, Bousounis D, Hoffman GM. Survival after chloroquine ingestion in a child. J Toxicol Clin Toxicol. 1988;26(5-6):381-8.
7. Coates PM, Hoffman GM, Finegold DN. Effect of thyroid hormones on human mononuclear leukocyte lysosomal acid lipase activity. J Clin Endocrinol Metab. 1982 Mar;54(3):559-62.
8. Hoffman GM, Torres A, Forster HV. Validation of a volumeless breath-by-breath method for measurement of respiratory quotient. J Appl Physiol (1985). 1993 Oct;75(4):1903-10.
9. Palmisano BW, Setlock MA, Doyle MK, Rosner DR, Hoffman GM, Eckert JE. Ventilatory response to carbon dioxide in term infants after halothane and nitrous oxide anesthesia. Anesth Analg. 1993 Jun;76(6):1234-7.
10. McNeely JK, Farber NE, Rusy LM, Hoffman GM. Epidural analgesia improves outcome following pediatric fundoplication. A retrospective analysis. Reg Anesth. 1997 Jan-Feb;22(1):16-23.
11. Hoffman GM, Ross GA, Day SE, Rice TB, Nelin LD. Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn. Crit Care Med. 1997 Feb;25(2):352-9.
12. Nelin LD, Hoffman GM. The use of inhaled nitric oxide in a wide variety of clinical problems. Pediatr Clin North Am. 1998 Jun;45(3):531-48.
13. Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas JP Jr, Ghanayem NS, Kessel MW, Litwin SB. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg. 1999 Jan;67(1):161-7; discussion 167-8.
14. Balasubramanyan N, Havens PL, Hoffman GM. Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med. 1999 Aug;27(8):1577-81.
15. Gordon JB, Rehorst-Paea LA, Hoffman GM, Nelin LD. Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets. Pediatr Res. 1999 Dec;46(6):735-41.
16. Schmidt JE, Tamburro RF, Hoffman GM. Dilated nonreactive pupils secondary to neuromuscular blockade. Anesthesiology. 2000 May;92(5):1476-80.
17. Tweddell JS, Hoffman GM, Fedderly RT, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB. Patients at risk for low systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg. 2000 Jun;69(6):1893-9.
18. Hoffman GM, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB, Tweddell JS. Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome. Ann Thorac Surg. 2000 Nov;70(5):1515-20; discussion 1521.
19. Nelin LD, Hoffman GM. L-arginine infusion lowers blood pressure in children. J Pediatr. 2001 Nov;139(5):747-9.
20. Rusy LM, Hoffman GM, Weisman SJ. Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy. Anesthesiology. 2002 Feb;96(2):300-5.
21. Hoffman GM, Nowakowski R, Troshynski TJ, Berens RJ, Weisman SJ. Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model. Pediatrics. 2002 Feb;109(2):236-43.
22. Tweddell JS, Hoffman GM, Mussatto KA, Fedderly RT, Berger S, Jaquiss RD, Ghanayem NS, Frisbee SJ, Litwin SB. Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients. Circulation. 2002 Sep 24;106(12 Suppl 1):I82-9.
23. Ghanayem NS, Hoffman GM, Mussatto KA, Cava JR, Frommelt PC, Rudd NA, Steltzer MM, Bevandic SM, Frisbee SS, Jaquiss RD, Litwin SB, Tweddell JS. Home surveillance program prevents interstage mortality after the Norwood procedure. J Thorac Cardiovasc Surg. 2003 Nov;126(5):1367-77.
24. Hoffman GM, Stuth EA, Jaquiss RD, Vanderwal PL, Staudt SR, Troshynski TJ, Ghanayem NS, Tweddell JS. Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion. J Thorac Cardiovasc Surg. 2004 Jan;127(1):223-33.
25. Robertson FA, Hoffman GM. Clinical evaluation of the effects of signal integrity and saturation on data availability and accuracy of Masimo SE and Nellcor N-395 oximeters in children. Anesth Analg. 2004 Mar;98(3):617-22, table of contents.
26. Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto KA, Stuth EA, Jaquis RD, Berger S. Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. J Thorac Cardiovasc Surg. 2004 Mar;127(3):738-45.
27. Jaquiss RD, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS. Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality. J Thorac Cardiovasc Surg. 2004 Apr;127(4):982-9.
28. Stuth EA, Stucke AG, Cava JR, Hoffman GM, Berens RJ. Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. Paediatr Anaesth. 2004 Oct;14(10):831-7.
29. Tweddell JS, Pelech AN, Frommelt PC, Jaquiss RD, Hoffman GM, Mussatto KA, Litwin SB. Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease. J Thorac Cardiovasc Surg. 2005 Mar;129(3):551-8.
30. Hoffman GM, Ghanayem NS, Tweddell JS. Noninvasive assessment of cardiac output. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2005:12-21.
31. Tweddell JS, Hoffman GM. Postoperative management in patients with complex congenital heart disease. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2002;5:187-205.
32. Tweddell JS, Pelech AN, Jaquiss RD, Frommelt PC, Mussatto KA, Hoffman GM, Litwin SB. Aortic valve repair. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2005:112-21.
33. Hoffman GM. Detection and prevention of neurologic injury in the intensive care unit. Cardiol Young. 2005 Feb;15 Suppl 1:149-53.
34. Willoughby RE Jr, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE. Survival after treatment of rabies with induction of coma. N Engl J Med. 2005 Jun 16;352(24):2508-14.
35. Hoffman GM, Mussatto KA, Brosig CL, Ghanayem NS, Musa N, Fedderly RT, Jaquiss RD, Tweddell JS. Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg. 2005 Oct;130(4):1094-100.
36. Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD. Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. Cardiol Young. 2006 Feb;16 Suppl 1:61-6.
37. Hoffman GM, Nelin LD. Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients. Lung. 2005 Nov-Dec;183(6):441-53.
38. Berens RJ, Meyer MT, Mikhailov TA, Colpaert KD, Czarnecki ML, Ghanayem NS, Hoffman GM, Soetenga DJ, Nelson TJ, Weisman SJ. A prospective evaluation of opioid weaning in opioid-dependent pediatric critical care patients. Anesth Analg. 2006 Apr;102(4):1045-50.
39. Hoffman GM. Neurologic monitoring on cardiopulmonary bypass: what are we obligated to do? Ann Thorac Surg. 2006 Jun;81(6):S2373-80.
40. Berens RJ, Stuth EA, Robertson FA, Jaquiss RD, Hoffman GM, Troshynski TJ, Staudt SR, Cava JR, Tweddell JS, Bert Litwin S. Near infrared spectroscopy monitoring during pediatric aortic coarctation repair. Paediatr Anaesth. 2006 Jul;16(7):777-81.
41. Lee KJ, Havens PL, Sato TT, Hoffman GM, Leuthner SR. Assent for treatment: clinician knowledge, attitudes, and practice. Pediatrics. 2006 Aug;118(2):723-30.
42. Hoffman GM. Pro: near-infrared spectroscopy should be used for all cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2006 Aug;20(4):606-12.
43. Jaquiss RD, Siehr SL, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS. Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome. Ann Thorac Surg. 2006 Oct;82(4):1260-5; discussion 1265-6.
44. Ghanayem NS, Jaquiss RD, Cava JR, Frommelt PC, Mussatto KA, Hoffman GM, Tweddell JS. Right ventricle-to-pulmonary artery conduit versus Blalock-Taussig shunt: a hemodynamic comparison. Ann Thorac Surg. 2006 Nov;82(5):1603-9; discussion 1609-10.
45. Kleinman ME, de Caen AR, Chameides L, Atkins DL, Berg RA, Berg MD, Bhanji F, Biarent D, Bingham R, Coovadia AH, Hazinski MF, Hickey RW, Nadkarni VM, Reis AG, Rodriguez-Nunez A, Tibballs J, Zaritsky AL, Zideman D, Pediatric Basic and Advanced Life Support Chapter Collaborators. Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics. 2010 Nov;126(5):e1261-318. PMCID: PMC3784274
46. Kleinman ME, de Caen AR, Chameides L, Atkins DL, Berg RA, Berg MD, Bhanji F, Biarent D, Bingham R, Coovadia AH, Hazinski MF, Hickey RW, Nadkarni VM, Reis AG, Rodriguez-Nunez A, Tibballs J, Zaritsky AL, Zideman D, Pediatric Basic and Advanced Life Support Chapter Collaborators. Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010 Oct 19;122(16 Suppl 2):S466-515. PMCID: PMC3748977
47. Bernal NP, Hoffman GM, Ghanayem NS, Arca MJ. Cerebral and somatic near-infrared spectroscopy in normal newborns. J Pediatr Surg. 2010 Jun;45(6):1306-10.
48. Taylor SP, Hoffman GM. Gas embolus and cardiac arrest during laparoscopic pyloromyotomy in an infant. Can J Anaesth. 2010 Aug;57(8):774-8.
49. Tweddell JS, Ghanayem NS, Hoffman GM. Pro: NIRS is "standard of care" for postoperative management. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13(1):44-50.
50. Rao RP, Danduran MJ, Hoffman GM, Ghanayem NS, Berger S, Frommelt PC. Cerebral hemodynamics in the presence of decreased systemic venous compliance in patients with Fontan physiology may limit anaerobic exercise capacity. Pediatr Cardiol. 2010 Feb;31(2):208-14.
51. Tweddell JS, Nersesian M, Mussatto KA, Nugent M, Simpson P, Mitchell ME, Ghanayem NS, Pelech AN, Marla R, Hoffman GM. Fontan palliation in the modern era: factors impacting mortality and morbidity. Ann Thorac Surg. 2009 Oct;88(4):1291-9.
52. Hanson SJ, Berens RJ, Havens PL, Kim MK, Hoffman GM. Effect of volume resuscitation on regional perfusion in dehydrated pediatric patients as measured by two-site near-infrared spectroscopy. Pediatr Emerg Care. 2009 Mar;25(3):150-3.
53. Rao RP, Danduran MJ, Frommelt PC, Ghanayem NS, Berger S, Simpson PM, Yan K, Hoffman GM. Measurement of regional tissue bed venous weighted oximetric trends during exercise by near infrared spectroscopy. Pediatr Cardiol. 2009 May;30(4):465-71.
54. Johnson BA, Hoffman GM, Tweddell JS, Cava JR, Basir M, Mitchell ME, Scanlon MC, Mussatto KA, Ghanayem NS. Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome. Ann Thorac Surg. 2009 Feb;87(2):571-7; discussion 577-9.
55. Peddy SB, Hazinski MF, Laussen PC, Thiagarajan RR, Hoffman GM, Nadkarni V, Tabbutt S. Cardiopulmonary resuscitation: special considerations for infants and children with cardiac disease. Cardiol Young. 2007 Sep;17 Suppl 2:116-26.
56. Tweddell JS, Ghanayem NS, Mussatto KA, Mitchell ME, Lamers LJ, Musa NL, Berger S, Litwin SB, Hoffman GM. Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. Ann Thorac Surg. 2007 Oct;84(4):1301-10; discussion 1310-1.
57. Frommelt PC, Sheridan DC, Mussatto KA, Hoffman GM, Ghanayem NS, Frommelt MA, Tweddell JS. Effect of shunt type on echocardiographic indices after initial palliations for hypoplastic left heart syndrome: Blalock-Taussig shunt versus right ventricle-pulmonary artery conduit. J Am Soc Echocardiogr. 2007 Dec;20(12):1364-73.
58. Ghanayem NS, Mitchell ME, Tweddell JS, Hoffman GM. Monitoring the brain before, during, and after cardiac surgery to improve long-term neurodevelopmental outcomes. Cardiol Young. 2006 Sep;16 Suppl 3:103-9.
59. Hoffman GM. Outcomes of pediatric anesthesia. Semin Pediatr Surg. 2008 May;17(2):141-51.
60. Ghanayem NS, Hoffman GM, Mussatto KA, Frommelt MA, Cava JR, Mitchell ME, Tweddell JS. Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease. J Thorac Cardiovasc Surg. 2010 Oct;140(4):857-63.
61. Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ. The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. Paediatr Anaesth. 2011 Apr;21(4):441-53.
62. Gandy KL, Mitchell ME, Pelech AN, Niebler RA, Hoffman G, Berger S. Aortic exclusion: a method of handling aortic insufficiency in the pediatric population needing mechanical circulatory support. Pediatr Cardiol. 2011 Dec;32(8):1231-3.
63. Ghanayem NS, Wernovsky G, Hoffman GM. Near-infrared spectroscopy as a hemodynamic monitor in critical illness. Pediatr Crit Care Med. 2011 Jul;12(4 Suppl):S27-32.
64. Cassidy LD, Jensen JN, Durkee CT, Calkins CM, Sato T, Tassone C, Kerschner J, Theilke RJ, Mitchell ME, Hoffman GM, Oldham KT. Creation and implementation of a prospective pediatric clinical outcomes registry. J Registry Manag. 2011;38(3):138-43.
65. Rao RP, Danduran MJ, Loomba RS, Dixon JE, Hoffman GM. Near-infrared spectroscopic monitoring during cardiopulmonary exercise testing detects anaerobic threshold. Pediatr Cardiol. 2012 Jun;33(5):791-6.
66. Chaves AH, Hoffman GM, Cava J, Simpson P, Samyn M Infant cardiac MRI using oscillatory ventilation: safe and effective. J Cardiovasc Magn Reson. 2012 Feb 1;14 Suppl 1:P122
67. Stuth EA, Hoffman GM. A sisyphean task: identifying physiologic risk and improving outcomes in complex congenital heart surgery. Anesthesiology. 2011 Nov;115(5):926-8.
68. Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD. Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. Cardiology in the Young. Cardiol Young. 2006 Feb;16 Suppl 1:61-6.
69. George M. Hoffman, Nancy S. Ghanayem Perioperative neuromonitoring in pediatric cardiac surgery: Techniques and targets Progress in Pediatric Cardiology. Volume 29, Issue 2, August 2010, Pages 123–130
70. Hoffman GM, Brosig CL, Mussatto KA, Tweddell JS, Ghanayem NS. Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg. 2013 Nov;146(5):1153-64.
71. Chaves AH, Cava JR, Simpson P, Hoffman GM, Samyn MM. Infant cardiac magnetic resonance imaging using oscillatory ventilation: safe and effective. Pediatr Cardiol. 2013 Jun;34(5):1201-5.
72. Scott JP, Hoffman GM. Near-infrared spectroscopy: exposing the dark (venous) side of the circulation. Paediatr Anaesth. 2014 Jan;24(1):74-88.
73. Abu-Sultaneh S, Hehir DA, Murkowski K, Ghanayem NS, Liedel J, Hoffmann RG, Cao Y, Mitchell ME, Jeromin A, Tweddell JS, Hoffman GM. Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass. Pediatr Crit Care Med. 2014 Mar;15(3):219-28.
74. Mussatto KA, Hoffmann RG, Hoffman GM, Tweddell JS, Bear L, Cao Y, Brosig C. Risk and prevalence of developmental delay in young children with congenital heart disease. Pediatrics. 2014 Mar;133(3):e570-7. PMCID: PMC3934337
75. Tweddell JS, Ghanayem NS, Hoffman GM. All this monitoring…what's necessary, what's not? Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2014;17(1):81-90.
76. Scott JP, Costigan DJ, Hoffman GM, Simpson PM, Dasgupta M, Punzalan R, Berens RJ, Tweddell JS, Stuth EA. Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery. J Clin Anesth. 2014 May;26(3):204-11.
77. Marino BS, Tibby SM, Hoffman GM. Resuscitation of the patient with the functionally univentricular heart. Curr Pediatr Rev. 2013;9(2):148-57.
78. Taylor SP, Sato TT, Balcom AH, Groth T, Hoffman GM. Gas analysis using Raman spectroscopy demonstrates the presence of intraperitoneal air (nitrogen and oxygen) in a cohort of children undergoing pediatric laparoscopic surgery. Anesth Analg. 2015 Feb;120(2):349-54.
79. Abu-Sultaneh S, Hehir DA, Murkowski K, Ghanayem NS, Liedel J, Hoffmann RG, Cao Y, Mitchell ME, Jeromin A, Tweddell JS, Hoffman GM. Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass. Pediatr Crit Care Med. 2014 Mar;15(3):219-28.
80. Mussatto KA, Hoffmann R, Hoffman G, Tweddell JS, Bear L, Cao Y, Tanem J, Brosig C. Risk Factors for Abnormal Developmental Trajectories in Young Children With Congenital Heart Disease. Circulation. 2015 Aug 25;132(8):755-61. PMCID: PMC4551137
81. Taylor SP, Hoffman GM. In Response. Anesth Analg. 2015 Nov;121(5):1402-3.
82. Hoffman GM, Brosig CL, Bear LM, Tweddell JS, Mussatto KA. Effect of Intercurrent Operation and Cerebral Oxygenation on Developmental Trajectory in Congenital Heart Disease. Ann Thorac Surg. 2016 Feb;101(2):708-16.
83. Niebler RA, Woods KJ, Murkowski K, Ghanayem NS, Hoffman G, Mitchell ME, Punzalan RC, Scott JP, Simpson P, Tweddell JS. A Pilot Study of Antithrombin Replacement Prior to Cardiopulmonary Bypass in Neonates. Artif Organs. 2016 Jan;40(1):80-5.
84. Brosig C, Mussatto K, Hoffman G, Hoffmann RG, Dasgupta M, Tweddell J, Ghanayem N. Neurodevelopmental outcomes for children with hypoplastic left heart syndrome at the age of 5 years. Pediatr Cardiol. 2013 Oct;34(7):1597-604. PMCID: PMC3982227
85. Siehr S, Stuth E, Tweddell J, Hoffman G, Troshynski T, Jones D, Mitchell M, Ghanayem N. Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery. Eur J Cardiothorac Surg. 2010 Feb;37(2):307-11.
86. Labovsky K, Hoffman G, Scott J. Management of a Patient With Tetralogy of Fallot, Congenital Diaphragmatic Hernia, and Complete Left Lung Agenesis. A A Case Rep. 2016 Jul 01;7(1):16-20.
87. Brosig C, Mussatto K, Hoffman G, Hoffmann RG, Dasgupta M, Tweddell J, Ghanayem N. Neurodevelopmental outcomes for children with hypoplastic left heart syndrome at the age of 5 years. Pediatr Cardiol. 2013 Oct;34(7):1597-604. PMCID: PMC3982227
88. Siehr S, Stuth E, Tweddell J, Hoffman G, Troshynski T, Jones D, Mitchell M, Ghanayem N. Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery. Eur J Cardiothorac Surg. 2010 Feb;37(2):307-11.
89. Mussatto KA, Hoffmann R, Hoffman G, Tweddell JS, Bear L, Cao Y, Tanem J, Brosig C. Risk Factors for Abnormal Developmental Trajectories in Young Children With Congenital Heart Disease. Circulation. 2015 Aug 25;132(8):755-61. PMCID: PMC4551137
90. Brosig C, Mussatto K, Hoffman G, Hoffmann RG, Dasgupta M, Tweddell J, Ghanayem N. Neurodevelopmental outcomes for children with hypoplastic left heart syndrome at the age of 5 years. Pediatr Cardiol. 2013 Oct;34(7):1597-604. PMCID: PMC3982227
91. Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD. Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. Cardiology in the Young. Cardiol Young. 2006 Feb;16 Suppl 1:61-6.
92. Hoffman GM, Ghanayem NS Perioperative neuromonitoring in pediatric cardiac surgery: Techniques and targets Progress in Pediatric Cardiology. Volume 29, Issue 2, August 2010, Pages 123–130
93. Ghanayem NS, Hoffman GM. Near Infrared Spectroscopy as a Hemodynamic Monitor in Critical Illness. Pediatr Crit Care Med. 2016 08;17(8 Suppl 1):S201-6.
94. Hoffman GM, Ghanayem NS, Scott JP, Tweddell JS, Mitchell ME, Mussatto KA. Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome. Ann Thorac Surg. 2017 May;103(5):1527-1535.
95. Marino BS, Tabbutt S, MacLaren G, Hazinski MF, Adatia I, Atkins DL, Checchia PA, DeCaen A, Fink EL, Hoffman GM, Jefferies JL, Kleinman M, Krawczeski CD, Licht DJ, Macrae D, Ravishankar C, Samson RA, Thiagarajan RR, Toms R, Tweddell J, Laussen PC, American Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Emergency Cardiovascular Care Committee. Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association. Circulation. 2018 05 29;137(22):e691-e782.
96. Niebler RA, Parker H, Hoffman GM. Impact of Anticoagulation and Circuit Technology on Complications During Extracorporeal Membrane Oxygenation. ASAIO J. 2019 Mar/Apr;65(3):270-276.
97. Scott JP, Hong JC, Thompson NE, Woods RK, Hoffman GM. Central ECMO for circulatory failure following pediatric liver transplantation. Perfusion. 2018 11;33(8):704-706.
98. Kim J, Zimmerman MA, Lerret SM, Scott JP, Voulgarelis S, Fons RA, Vitola BE, Telega GW, Hoffman GM, Berens RJ, Hong JC. Staged biliary reconstruction after liver transplantation: A novel surgical strategy for high acuity pediatric transplant recipients. Surgery. 2019 02;165(2):323-328.
99. Kim J, Fons RA, Scott JP, Eriksen CM, Lerret SM, Browning MB, Telega GW, Vitola BE, Hoffman GM, North PE, Vo NN, Zimmerman MA, Hong JC. Transabdominal Intrapericardial Approach in Liver Transplantation for Unresectable Primary Hepatic Functioning Paraganglioma With Invasion Into Hepatic Veins and Suprahepatic Vena Cava: A Surgical and Anesthesia Management Challenge. Transplant Proc. 2018 Nov;50(9):2630-2635.
100. Bryant R, Reagor JA, Hoffman GM, Tweddell JS. Surgical Techniques Anderson's Pediatric Cardiology 4th Edition. .
101. Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S. Hypoplastic left heart syndrome Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult: Ninth Edition. 2 February 2016;2.
102. Hoffman GM, Ghanayem NS, Tweddell JS. Non-invasive monitoring of oxygen delivery Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. 1 January 2014:835-855.
103. Marino BS, Tibby SM, Hoffman GM. Resuscitation of the patient with the functionally univentricular heart Current Pediatric Reviews. 2013;9(2):148-157.
104. Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S. Hypoplastic left heart syndrome Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult: Eighth Edition. 30 May 2013;2-2.
105. Hoffman GM, Tweddell JS. Regional blood flow monitoring in the perioperative period Hemodynamics and Cardiology. 2012:473-487.
106. Fischler M. Occurrence of a carbon dioxide embolism during laparoscopic pyloromyotomy in a small child: several unresolved questions. Can J Anaesth. 2011 Feb;58(2):226; author reply 226-7.
107. Gandy KL, Hoffman GM, Vanderwal P, Tweddell JS. Surgical techniques Paediatric Cardiology. 2010:219-237.
108. Hoffman GM, Ghanayem NS. Perioperative neuromonitoring in pediatric cardiac surgery: Techniques and targets Progress in Pediatric Cardiology. August 2010;29(2):123-130.
109. Cohn AI. Acupuncture for postoperative nausea and vomiting prophylaxis: where's the point? Anesthesiology. 2002 Oct;97(4):1038-9; author reply 1039.
110. Hoffman GM. Airway complications of instrumentation: A physiologic approach Respiratory Care. 1995;40(1):97-107.
111. Hoffman GM. Relief of Pain and Anxiety in the PICU: Neither Too Much Too Soon Nor Too Little Too Late Journal of Intensive Care Medicine. November 1995;10(6):267-269.
112. . Dexamethasone therapy for bacterial meningitis. N Engl J Med. 1989 Feb 16;320(7):463-5.
113. Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S.. Hypoplastic Left Heart Syndrome (Chapter 46). Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, 9th Edition, ed. HD Allen. Lippincott Williams & Wilkins, Baltimore, MD 2016.. .
114. Woods RK, Hoffman GH. Uh-oh, some CO<sub>2</sub> has gone missing. J Thorac Cardiovasc Surg. 2018 09;156(3):1179-1180.
115. Ghanayem-NS, Ahmed-M, Anders-MM, Tume-SC, Yu-EL, Hoffman-GM.. Monitoring Systems Critical Heart Disease in Infants and Children, 3rd Edition, 22, 245-260.e5, ed. RM Ungerleider, JN Meliones, K Nelson McMillan, DS Cooper, JP Jacobs, Elsevier, 2019. .
116. Bigelow AM, Ghanayem NS, Thompson NE, Scott JP, Cassidy LD, Woods KJ, Woods RK, Mitchell ME, Hraŝka V, Hoffman GM. Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study. Ann Thorac Surg. 2019 12;108(6):1865-1874.
117. Gellings JA, Johnson WK, Ghanayem NS, Mitchell M, Tweddell J, Hoffman G, Hraska V, Kuhn EM, Woods RK. Norwood Procedure-Difficulty in Weaning From Cardiopulmonary Bypass and Implications for Outcomes. Semin Thorac Cardiovasc Surg. 2020;32(1):119-125. PMCID: PMC7007819
118. Hoffman GM, Scott JP, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Niebler RA, Bertrandt RA, Mussatto KA, Tweddell JS. Identification of Time-Dependent Risks of Hemodynamic States After Stage 1 Norwood Palliation. Ann Thorac Surg. 2020 01;109(1):155-162.
119. Spector A, Brazauskas R, Hainsworth K, Hoffman GM, Weisman S, Cassidy LD. Changes in Health Care Utilization for Pediatric Patients Treated at a Specialized Outpatient Pain Clinic. WMJ. 2019 Dec;118(4):164-168.
120. Hraska V, Mitchell ME, Woods RK, Hoffman GM, Kindel SJ, Ginde S. Innominate Vein Turn-down Procedure for Failing Fontan Circulation Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual. 2020.
121. Ghanayem NS, Ahmed M, Anders MM, Tume SC, Vu EL, Hoffman GM. Monitoring systems Critical Heart Disease in Infants and Children. 1 January 2018:245-260.e5.
122. Hraska V, Mitchell ME, Woods RK, Hoffman GM, Kindel SJ, Ginde S. Innominate Vein Turn-down Procedure for Failing Fontan Circulation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2020;23:34-40.
123. Hoffman GM, Niebler RA, Scott JP, Bertrandt RA, Wakeham MK, Thompson NE, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Mussatto KA, Tweddell JS. Interventions Associated with Treatment of Low Cardiac Output following Stage 1 Norwood Palliation. Ann Thorac Surg. 2020 Jul 08.
124. Transabdominal Intrapericardial Approach in Liver Transplantation for Unresectable Primary Hepatic Functioning Paraganglioma With Invasion Into Hepatic Veins and Suprahepatic Vena Cava: A Surgical and Anesthesia Management Challenge. Transplant Proc 2018 Nov;50(9):2630-2635 PMID: 30401364 11/08/2018. Kim J, Fons RA, Scott JP, Eriksen CM, Lerret SM, Browning MB, Telega GW, Vitola BE, Hoffman GM, North PE, Vo NN, Zimmerman MA, Hong JC.
125. Staged biliary reconstruction after liver transplantation: A novel surgical strategy for high acuity pediatric transplant recipients. Surgery 2019 Feb;165(2):323-328 PMID: 30268374 10/01/2018. Kim J, Zimmerman MA, Lerret SM, Scott JP, Voulgarelis S, Fons RA, Vitola BE, Telega GW, Hoffman GM, Berens RJ, Hong JC.
126. Central ECMO for circulatory failure following pediatric liver transplantation. Perfusion 2018 11;33(8):704-706 PMID: 29788811 05/24/2018. Scott JP, Hong JC, Thompson NE, Woods RK, Hoffman GM.
127. Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association. Circulation 2018 29;137(22):e691-e782 PMID: 29685887 04/25/2018. Marino BS, Tabbutt S, MacLaren G, Hazinski MF, Adatia I, Atkins DL, Checchia PA, DeCaen A, Fink EL, Hoffman GM, Jefferies JL, Kleinman M, Krawczeski CD, Licht DJ, Macrae D, Ravishankar C, Samson RA, Thiagarajan RR, Toms R, Tweddell J, Laussen PC, American Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Emergency Cardiovascular Care Committee.
128. Niebler RA, Parker H, Hoffman GM. Impact of Anticoagulation and Circuit Technology on Complications During Extracorporeal Membrane Oxygenation. ASAIO J 2019 Mar/Apr;65(3):270-276 PMID: 29746314 05/11/2018.
 
Books, Chapters, and Reviews
1. Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berser S. Hypoplastic Left Heart Syndrome : Moss & Adam’s Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, 10e, eds. Robert E. Shaddy, Daniel J. Penny, Timothy F. Feltes, Frank Cetta, Seema Mital, Wolters Kluwer. .
2. Monitoring Systems. In: Critical Heart Disease in Infants and Children, 3rd Edition, 22, 245-260.e5, ed. RM Ungerleider, JN Meliones, K Nelson McMillan, DS Cooper, JP Jacobs, Elsevier, Inc, 2019. Ghanayem-NS, Ahmed-M, Anders-MM, Tume-SC, Yu-EL, Hoffman-GM.
 
Editorials, Letters to Editor, Other
1. Uh-oh, some CO2 has gone missing. J Thorac Cardiovasc Surg. 2018 Jun 5: S0022-5223(18)31497-1. PMID: 29958662. Woods RK, Hoffman G.
 

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