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CURRICULUM VITAE

Guan Chen MD, PhD
Professor
Department of Pharmacology and Toxicology

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-456-8636
Email: gchen@mcw.edu

EDUCATION:
01/1982 - Present MD, Bengbu Medical College, Anhui, P.R. China
1982 MD, Bengbu Medical College, Anhui, P.R. China
01/1985 - Present MS, Sun Yat-Sen University, GuangZhou, P.R. China
1985 MS, Sun Yat-Sen University, GuangZhou, P.R. China
01/1990 - Present PhD, University of Heidelberg, Heidelberg, Germany
1990 PhD, University of Heidelberg, Heidelberg, Germany
01/1995 - Present Post Doctorate, Dana-Farber Cancer Institute, Harvard Medical School, Boston
1995 Post Doctorate, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

FACULTY APPOINTMENTS:
01/1986 - 12/1987 Research Associate, Cancer Institute, Sun Yat-Sen University, GuangZhou, P.R. China
1986 - 1987 Research Associate, Cancer Institute, Sun Yat-Sen University, GuangZhou, P.R. China
01/1988 - Present Lecturer, Cancer Institute, Sun Yat-Sen University, GuangZhou, P.R. China
01/1988 - 12/1992 Guest Scientist, Inst. of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, Germany
1988 Lecturer, Cancer Institute, Sun Yat-Sen University, GuangZhou, P.R. China
1988 - 1992 Guest Scientist, Inst. of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, Germany
01/1992 - 12/1995 Postdoctoral Research Fellow, Dana-Farber Institute, Harvard Medical School, MA, Division of Cancer Pharmacology, Boston
1992 - 1995 Postdoctoral Research Fellow, Dana-Farber Institute, Division of Cancer Pharmacology, Harvard Medical School, Boston, MA
01/1995 - 12/2000 Assistant Professor, Department of Molecular Biology, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH
1995 - 2000 Assistant Professor, Department of Molecular Biology, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH
09/01/2000 - Present Associate Professor, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153
09/2000 - Present Associate Professor, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153
07/01/2003 - Present Associate Professor, Department of Radiation Oncology, Loyola University of Chicago, Maywood, IL 60153
07/2003 - Present Associate Professor, Department of Radiation Oncology, Loyola University of Chicago, Maywood, IL 60153
02/01/2004 - Present Associate Professor, Department of Pharmacology and Experimental Therapeutics, Loyola University of Chicago, Maywood, IL 60153
02/2004 - Present Associate Professor, Department of Pharmacology and Experimental Therapeutics, Loyola University of Chicago, Maywood, IL 60153
03/01/2006 - Present Professor, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226
03/2006 - Present Professor, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
09/01/2000 - Present Member of Molecular Biology Program, Graduate School, Loyola University of Chicago, Maywood, IL 60153
09/01/2000 - Present Member of Molecular and Cellular Biochemistry Program, Graduate School, Loyola University of Chicago, Maywood, IL 60153
09/2000 - Present Member of Molecular and Cellular Biochemistry Program, Graduate School, Loyola University of Chicago, Maywood, IL 60153
09/2000 - Present Member of Molecular Biology Program, Graduate School, Loyola University of Chicago, Maywood, IL 60153

AWARDS AND HONORS:
1988 - 1992 Guest Scientist Scholarship, German Cancer Research Center (DKFZ) in Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, Germany
1988 - 1992 Guest Scientist Scholarship, German Cancer Research Center (DKFZ) in Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, Germany
1989 - Present Gerhard-Domagk Award
1989 Gerhard-Domagk Award

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1997 - Present New York Academy of Sciences (Active Member)
1997 - Present New York Academy of Sciences (Active Member)
2012 - Present Federation of American Societies for Experimental Biology (Member)
2012 - Present American Society for Pharmacology and Experimental Therapeutics (Member)
2012 - Present American Society for Biochemistry and Molecular Biology (Member)
2012 - Present American Association for Cancer Research (Active Member)
American Society for Pharmacology and Experimental Therapeutics (Member)
American Association for Cancer Research (Active Member)
Federation of American Societies for Experimental Biology (Member)
American Society for Biochemistry and Molecular Biology (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
2001 - Present Frontier in Biosciences
2001 - Present Frontier in Biosciences
2006 - 2010 International Journal of Cancer Research
2006 - 2010 International Journal of Cancer Research
2010 - Present American Journal of Cancer Research
2010 - Present American Journal of Cancer Research
Journal Review
2012 - Present Cancer Res., Blood, Int. J. Cancer, Oncogene, BBRC, Carcinogenesis, FASEB J., BBA, Int J Biol Sci
Cancer Res., Blood, Int. J. Cancer, Oncogene, BBRC, Carcinogenesis, FASEB J., BBA, Int J Biol Sci

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
01/2000 - 12/2006 Member, Recruiting Committee for Cancer Center, Department of Radiation Oncology; Department of Urology, and Program of Hematology, and Skin Cancer Program, Loyola University
01/2000 - 12/2002 Co-Chair, Research Safety Committee, Hines VA Medical Center, Loyola University
2000 - 2006 Member, Recruiting Committee for Cancer Center, Department of Radiation Oncology; Department of Urology, and Program of Hematology, and Skin Cancer Program, Loyola University
2000 - 2002 Co-Chair, Research Safety Committee, Hines VA Medical Center, Loyola University
01/2002 - Present Member, Graduate admission committee, Molecular Biology Program, Loyola University of Chicago
01/2002 - 12/2004 Member, Research Safety Committee, Hines VA Medical Center
2002 - Present Member, Graduate admission committee, Molecular Biology Program, Loyola University of Chicago
2002 - 2004 Member, Research Safety Committee, Hines VA Medical Center
01/2003 - 12/2006 Member, Faculty recruiting committee, Department of Pharmacology, Loyola University
2003 - 2006 Member, Faculty recruiting committee, Department of Pharmacology, Loyola University
01/2004 - Present Member, Research & Development Committee, Research Services, Hines VA Medical Center
01/2004 - 12/2006 Member, Hematology/Oncology Grand Review Panel, Cancer Center, Loyola University of Chicago
01/2004 - 12/2006 Member, Core Curriculum Oversight Committee, Loyola Graduate School, Loyola University of Chicago
01/2004 - Present Member, Graduate admission committee, Department of Pharmacology, Loyola
2004 - 2006 Member, Core Curriculum Oversight Committee, Loyola Graduate School, Loyola University of Chicago
2004 - Present Member, Research & Development Committee, Research Services, Hines VA Medical Center
2004 - 2006 Member, Hematology/Oncology Grand Review Panel, Cancer Center, Loyola University of Chicago
2004 - Present Member, Graduate admission committee, Department of Pharmacology, Loyola
01/2006 - Present Member, PhD candidate Recruiting, Graduate School, Medical College of Wisconsin
01/2006 - Present Member, Blood Institute of Wisconsin Recruiting, Medical College of Wisconsin
01/2006 - Present Member, Department of Biochemistry recruiting Committee, Medical College of Wisconsin
01/2006 - Present Member, Department of Medicine/Division of Endocrinology recruiting, Medical College of Wisconsin
01/2006 - Present Member, Cancer Center Open House, Medical College of Wisconsin
01/2006 - Present Member, Department of Pharmacology recruiting Committee, Medical College of Wisconsin
2006 - Present Member, Department of Medicine/Division of Endocrinology recruiting, Medical College of Wisconsin
2006 - Present Member, Blood Institute of Wisconsin Recruiting, Medical College of Wisconsin
2006 - Present Member, Cancer Center Open House, Medical College of Wisconsin
2006 - Present Member, Department of Pharmacology recruiting Committee, Medical College of Wisconsin
2006 - Present Member, PhD candidate Recruiting, Graduate School, Medical College of Wisconsin
2006 - Present Member, Department of Biochemistry recruiting Committee, Medical College of Wisconsin
01/2007 - 12/2008 Member, Curriculum and Programs Committee, Graduate School, Medical College of Wisconsin
01/2007 - Present Recruiting Director, Department of Pharmacology and Toxicology, Medical College of Wisconsin
2007 - 2008 Member, Curriculum and Programs Committee, Graduate School, Medical College of Wisconsin
2007 - Present Recruiting Director, Department of Pharmacology and Toxicology, Medical College of Wisconsin

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Estrogen Receptor, p38gamma MAPK and topo lla in breast cancers
Source:
Merit Review
Dates:
10/01/2007 - 09/01/2013
Direct Funds:
$220,000
 
Title:
Estrogen receptor, p38 MAPK and topo IIa in breast cancer
Source:
Merit Review
Dates:
01/01/2009 - 12/01/2013
Direct Funds:
$150,000
 
Title:
Estrogen receptor, p38 MAPK and topo IIa in breast cancers
Source:
Merit Review
Dates:
2009 - 2013
Direct Funds:
$150,000
 
Pending
Peer Review
Title:
A MAPK and transcription factor axis in Ras oncogenesis
Source:
NIH R01
 
Title:
Regulating breast cancer hormone sensitivity by p38 MAPK
Source:
Cancer Center (MCW)
 
Title:
A MAPK and transcription factor axis in Ras oncogenesis
Source:
NIH
 
Title:
Regulating breast cancer hormone sensitivity by p38 MAPK
Source:
MCW Cancer Center
 
Prior
Peer Review
Title:
Inhibition of Ras mitogenic signaling by the p38 pathway
Source:
NIH
Dates:
01/01/2000 - 12/31/2005
Direct Funds:
$1,080,530
 
Title:
Inhibition of Ras mitogenic signaling by the p38 pathway
Source:
NIH R01 (CA91576)
Dates:
2000 - 2005
Direct Funds:
$1,080,530
 
Title:
Estrogen receptor regulates c-Jun activity in breast cancer cells
Source:
Merit Review Department of Veteran Affairs
Dates:
01/01/2006 - 12/31/2009
Direct Funds:
$202,000
 
Title:
Regulation of Ras activity by the p38 pathway
Source:
NIH
Dates:
01/01/2006 - 12/31/2011
Direct Funds:
$155,000
 
Title:
Estrogen receptor regulates c-Jun-dependent cell death
Source:
Charlotte Geyer Foundation
Dates:
01/01/2006 - 12/31/2007
Direct Funds:
$75,000
 
Title:
VDR inhibits stress-induced cell death
Source:
MCW Cancer Center
Dates:
01/01/2006 - 12/31/2007
Direct Funds:
$25,000
 
Title:
Estrogen receptor regulates c-Jun-dependent cell death
Source:
Charlotte Geyer Foundation
Dates:
2006 - 2007
Direct Funds:
$75,000
 
Title:
Regulation of Ras activity by the p38 pathway
Source:
NIH R01
Dates:
2006 - 12/31/2011
Direct Funds:
$155,000
 
Title:
VDR inhibits stress-induced cell death
Source:
MCW Cancer Center
Dates:
2006 - 2007
Direct Funds:
$25,000
 
Title:
Estrogen receptor regulates c-Jun activity in breast cancer cells
Source:
Merit Review Department of Veteran Affairs
Dates:
2006 - 2009
Direct Funds:
$202,000
 
Title:
Regulation of breast cancer invasion by p38 MAPK
Source:
MCW Cancer Center
Dates:
01/01/2008 - 12/31/2010
 
Title:
Regulation of breast cancer invasion by p38 MAPK
Source:
MCW Cancer Center
Dates:
2008 - 2010
 
Title:
Estrogen receptor and vitamin D receptor cooperate in regulating breast cancer invasion
Source:
MCW Cancer Center
Dates:
01/01/2009 - 12/31/2011
Direct Funds:
$138,000
 
Title:
Estrogen receptor and vitamin D receptor cooperate in regulating breast cancer invasion
Source:
Cancer Center (MCW)
Dates:
2009 - 2011
Direct Funds:
$138,000
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Department of Biology, Toledo University, Toledo, OH, 2000
Medical College of Wisconsin, Department of Pharmacology, Milwaukee, WI, 2005
Department of Biology, Toledo University, Toledo, OH, 2000
Medical College of Wisconsin, Department of Pharmacology, Milwaukee, WI, 2005
 
Regional
Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH, 2000
Department of Radiation Oncology, Washington University in St. Louis, MO, 2000
Cancer Center, Loyola University Medical Center, Chicago, IL, 2000
Molecular Biology Program, Loyola University of Chicago, 2001
Program in Molecular and Cellular Biochemistry, Loyola University of Chicago, 2002
Department of Pharmacology and Experimental Therapeutics, Loyola University of Chicago, 2003
Program in Molecular Biology, Loyola University of Chicago, 2004
Department of Radiation Oncology, Loyola University of Chicago, 2005
Barbara Ann Karmanos Cancer Institute, Detroit, MI, 2006
Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH, 2000
Department of Radiation Oncology, Washington University in St. Louis, MO, 2000
Cancer Center, Loyola University Medical Center, Chicago, IL, 2000
Molecular Biology Program, Loyola University of Chicago, 2001
Program in Molecular and Cellular Biochemistry, Loyola University of Chicago, 2002
Department of Pharmacology and Experimental Therapeutics, Loyola University of Chicago, 2003
Program in Molecular Biology, Loyola University of Chicago, 2004
Department of Radiation Oncology, Loyola University of Chicago, 2005
Barbara Ann Karmanos Cancer Institute, Detroit, MI, 2006
 
National
Isis Pharmaceutical, CA, 2000
Department of Pharmacology, George Washington University, Washington, DC, 2000
Tulane Cancer Center, Tulane University, New Orleans, LA, 2005
Department of Biochemistry, Virginia Commonwealth University (VCU), Richmond, Virginia, 2005
Department of Pediatrics and Cancer Center, University of Louisville, 2005
Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, 2005
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 2005
Isis Pharmaceutical, CA, 2000
Department of Pharmacology, George Washington University, Washington, DC, 2000
Tulane Cancer Center, Tulane University, New Orleans, LA, 2005
Department of Biochemistry, Virginia Commonwealth University (VCU), Richmond, Virginia, 2005
Department of Pediatrics and Cancer Center, University of Louisville, 2005
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 2005
Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, 2005
 
International
Symposium for Cancer Drug Resistance, Kiel, Germany, 1990
Annual German Cancer Research Meeting, Heidelberg, Germany, 1991
International Conference of Chemotherapy, Berlin, Germany, 1991
12th World Congress on Advances in Oncology, Crete, Greece, 2007
Symposium for Cancer Drug Resistance, Kiel, Germany, 1990
Annual German Cancer Research Meeting, Heidelberg, Germany, 1991
12th World Congress on Advances in Oncology, Crete, Greece, 2007
International Conference of Chemotherapy, Berlin, Germany, 1991
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
01/01/2007 - 05/01/2007 Present Medical Pharmacology (Small group)
2007 - Present Medical Pharmacology (Small group)
01/01/2008 - 05/01/2008 Present Pharmacology, Herbs and Supplemental Medicine (lecture)
2008 - Present Pharmacology, Herbs and Supplemental Medicine (lecture)
 
Graduate Student Education
01/01/2006 - 12/31/2011 Present Nuclear Receptors-Mechanisms of Cellular Signaling (Course #16250) and the Course Director (2011)
2006 - Present Nuclear Receptors-Mechanisms of Cellular Signaling (Course #16250) and the Course Director (2011)
01/01/2008 - 12/31/2012 Present MAPKs and PI3Ks-Cellular Signal Transduction/ (Course #07224)
01/01/2008 - 12/31/2012 Present Analytic Methods in Pharmacology and Toxicology-Protein-protein interaction (Course #07243)
2008 - Present MAPKs and PI3Ks-Cellular Signal Transduction/ (Course #07224)
2008 - Present Analytic Methods in Pharmacology and Toxicology-Protein-protein interaction (Course #07243)
01/01/2010 - 12/31/2012 Present Cancer Genetics-Ras/MAPK signaling in cancer (Course #05251)
2010 - Present Cancer Genetics-Ras/MAPK signaling in cancer (Course #05251)
 

EXTRAMURAL TEACHING:
Medical Student Education
01/01/2001 - 10/31/2012 Present Department of Radiation Oncology, Loyola University of Chicago, Signal transduction, Genomic Instability
2001 - Present Department of Radiation Oncology, Loyola University of Chicago, Signal transduction, Genomic Instability
01/01/2002 - 12/31/2002 Department of Radiation Oncology, Loyola University of Chicago, MAPK and DNA repair, MAPK and Radiation response
2002 Department of Radiation Oncology, Loyola University of Chicago, MAPK and DNA repair, MAPK and Radiation response
01/01/2004 - 12/31/2005 Department of Radiation Oncology, Loyola University of Chicago, 1) Apoptosis & Radiation 2) Cell Kinetics (Radiobiology Basis)
2004 - 2005 Department of Radiation Oncology, Loyola University of Chicago, 1) Apoptosis & Radiation 2) Cell Kinetics (Radiobiology Basis)
 
Graduate Student Education
01/2001 - 12/2001 Loyola University of Chicago, Signal transduction Special Core Curriculum (#MIIM502817)
01/2001 - 05/2003 Loyola University of Chicago, Oncogenesis Molecular Biology Program (#MB10590)
01/2001 - 05/2002 Present Loyola University of Chicago, MAPK signaling Physiology (#471), Molecular Biology (#527), CBNA (#441)
2001 - Present Loyola University of Chicago, MAPK signaling Physiology (#471), Molecular Biology (#527), CBNA (#441)
2001 - 2003 Loyola University of Chicago, Oncogenesis Molecular Biology Program (#MB10590)
2001 Loyola University of Chicago, Signal transduction Special Core Curriculum (#MIIM502817)
01/2002 - 05/2003 Loyola University of Chicago, DNA repair Molecular Biology (#526)
2002 Loyola University of Chicago, DNA repair Molecular Biology (#526)
01/2005 - 05/2004 Present Loyola University of Chicago, Nuclear receptors Pharmacology (#409)
2005 - Present Loyola University of Chicago, Nuclear receptors Pharmacology (#409)
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Students Advised
Rocky Pramanik, Medical College of Wisconsin, 2001 - 2003 Science Research, Co Scientist
Zan Huang, Medical College of Wisconsin, 2002 Molecular Biology Rotating
Viral Brahmbhatt, Medical College of Wisconsin, 2003 CBNA/Biochemistry Rotating
Jun Tang, Medical College of Wisconsin, 2003 - 2005 University of Chicago Research Asso
Sreevidya Sivaswamy, Medical College of Wisconsin, 2004 Biochemistry Rotating
Mathew Loesch, Medical College of Wisconsin, 2005 - Present Pharmacology Mentor
Amy Sasman, Medical College of Wisconsin, 2007 Pharmacology Rotating
Elizabeth Ntantie, Medical College of Wisconsin, 2007 IDP/Graduate School Rotating
Dusanka Vesic, Medical College of Wisconsin, 2008 IDP/Graduate School Rotating
Nicole Pohl, Medical College of Wisconsin, 2008 Pharmacology/MCW Mentor
Kristin Aicher, Medical College of Wisconsin, 2008 IDP/Graduate School Rotating
Adrinne Lepp, Medical College of Wisconsin, 2008 IDP/Graduate School Rotating
Justin Reitsman, Medical College of Wisconsin, 2008 IDP/Graduate School Rotating
Brandon-Rindfleisch, Medical College of Wisconsin, 2009 IDP/Graduate School Rotating
Mathew Loesch, Medical College of Wisconsin, 2009 Pharmacology/MCW Mentor
Yusuke Kobayashi, Medical College of Wisconsin, 2010 Yokohama City Co-Mentor University, Japan
Mansi Karkhanis, Medical College of Wisconsin, 2010 IDP/Graduate School Rotating
Yalin Li, Medical College of Wisconsin, MCW Postdoc fellow
Songwang Hou, Medical College of Wisconsin, MCW Postdoc associate
Huiying Zhi, Medical College of Wisconsin, MCW Postdoc fellow
MA Students Advised
Zan Huang, MCW, 2002 - Present Molecular Biology Rotating
Jun Tang, MCW, 2003 - 2005 University of Chicago Research Asso
Viral Brahmbhatt, MCW, 2003 - Present CBNA/Biochemistry Rotating
Sreevidya Sivaswamy, MCW, 2004 - Present Biochemistry Rotating
Elizabeth Ntantie, MCW, 2007 - Present IDP/Graduate School Rotating
Kristin Aicher, MCW, 2008 - Present IDP/Graduate School Rotating
Adrinne Lepp, MCW, 2008 - Present IDP/Graduate School Rotating
Dusanka Vesic, MCW, 2008 - Present IDP/Graduate School Rotating
Brandon-Rindfleisch, MCW, 2009 - Present IDP/Graduate School Rotating
Huiying Zhi, MCW, Postdoc fellow
Songwang Hou, MCW, Postdoc associate
Yalin Li, MCW, Postdoc fellow
MS Students Advised
Stanley J. Borowicz, Medical College of Wisconsin, 2002 - 2003 CBNA/Biochemistry Co-Mentor
Stanley J. Borowicz, Medical College of Wisconsin, 2003 CBNA/Biochemistry Co-Mentor Loyola
Nicole Pohl, Medical College of Wisconsin, 2004 - Present Molecular Biology Mentor
Melanie Weytkow, Medical College of Wisconsin, 2004 Pharmacology Summer
Amrita Dhupelia, Medical College of Wisconsin, 2005 Pharmacology Summer
Adrienne Lepp, Medical College of Wisconsin, 2011 Pharmacology/MCW Mentor
Adrienne Lepp, Medical College of Wisconsin, MCW Student
Xiaomei Qi, Medical College of Wisconsin
PhD Committees
Haixi Miao, Medical College of Wisconsin, 2002 - 2005 Supervisor, Lucio Miller
Qinping Li, Medical College of Wisconsin, 2004 - 2005 Nanjing Medical Professor in China
Nicole Pohl, Medical College of Wisconsin, 2004 - 2009 Supervisor, Dr. Guan Chen
Qinping Li, Medical College of Wisconsin, 2004 - 2005 Nanjing Medical Professor in China
Mathew Loesch, Medical College of Wisconsin, 2005 - 2009 Supervisor, Dr. Guan Chen
Tracy Berg, Medical College of Wisconsin, 2008 - 2010 Supervisor, Carol William (Pharmacology)
Hong Guan, Medical College of Wisconsin, 2008 - 2009 Supervisor, Robert Descheins, Biochemistry
Nathan Schuld, Medical College of Wisconsin, 2009 IDP/Graduate School Rotating
MS Committees
Stanley Borowicz, Medical College of Wisconsin, 2003 - 2005 Mater, Supervisor, Dr. Guan Chen
Adam Gastonguy, Medical College of Wisconsin, 2009 - Present (Pharmacology), Supervisor, Carol William
Jaclyn Porath, Medical College of Wisconsin, 2009 - Present (Blood Research Inst), Gil White
Adrienne Lepp, Medical College of Wisconsin, 2010 - Present (Pharmacology), Supervisor, Guan Chen
Benjamin Tourdot, Medical College of Wisconsin, 2010 (Blood Research Inst), Debra Newman
Anna Alexanian, Medical College of Wisconsin, 2010 (Microbiology), Supervisor, Andrey Sorokin
Elizabeth Ntantie, Medical College of Wisconsin, 2011 - Present (Pharmacology), Supervisor, Carol William
MA Committees
Nathan Schuld, Medical College of Wisconsin, 2009 - Present IDP/Graduate School Rotating
MPh Students Advised
Jessica Wilson, Medical College of Wisconsin, 2010 Medical School Rotating
 
Postdoctoral Students
Jin-Tang Wang, Medical College of Wisconsin, 2000 - 2001 Canada Postdoc
Zan Huang, Medical College of Wisconsin, 2001 - 2002 University of Chicago Postdoc
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Committees
Haixi Miao, Loyola University of Chicago, 2000 - 2006 candidate for Biochemistry and Cell Biology Program, (Advisor: Lucia Miller)
Student Name 3, UW-Milwaukee, 01/2001 - 06/2003 Dissertation title
Anisha Dcosta, Loyola University of Chicago, 2002 - 2004 candidate for Molecular Biology Program (Advisor: Mitch Denning)
Charles Gunawan, 2004 - Present candidate for Pharmacology (Advisor: Tarun B. Patel)
Vigneshwran Krishnamoorthy, Loyola University of Chicago, 2004 candidate for Department of Cellular and Molecular Physiology (Advisor: Jody L. Martin)
Matew Loesch, Loyola University of Chicago, 2005 candidate for Department of Pharmacology (Advisor: Guan Chen)
Rakesh Singh, Loyola University of Chicago, 2005 candidate for Department of Pharmacology (Advisor: Tarun Patel)
Anita Jerome, Loyola University of Chicago, 2005 candidate for Molecular Biology Program (Adviser: Mitch Denning)
Nicole Phol, Loyola University of Chicago, 2005 candidate for Molecular Biology Program (Advisor: Guan Chen)
MS Committees
Stanley Borowicz, Loyola University of Chicago, 2001 - 2003 a Master candidate for CBNA (Advisors: Guan Chen & Richard Schultz)
Yuanbin Chen, Loyola University of Chicago, 2003 - Present candidate for Molecular Biology Program (Advisor: Yan Su)
Vigneshwran Krishnamoorthy, Loyola University of Chicago, 2006 Program in Cellular and Molecular Physiology
MA Committees
 

GRANT REVIEW/STUDY SECTION:
01/01/2001 - 12/31/2001 Ohio Cancer Association, Florida Cancer Association
01/01/2001 - 12/31/2001 Present Ohio Cancer Association, Florida Cancer Association
01/01/2006 - 12/31/2006 Ad hoc scientific reviewer for DOD, Breast Cancer Research Program (CET-4, Clinical & Experimental Therapeutics #4 panel)
01/01/2006 - 10/12/2012 Cancer Center, Medical College of Wisconsin (MCW)
01/01/2007 - 12/31/2007 Ad hoc scientific reviewer for NIH MONC study section (Molecular Oncogenesis), ARRA RC1 Challenge Grant (ZRG1 OTC-K 58)
01/01/2007 - 10/12/2012 Ad hoc scientific reviewer for Special Research Program (SFB, Cell Proliferation and Cell Death in Tumors), Austrian Science Foundation (FWF), The Wellcome- Trust Foundation, England; Health Research Board, Ireland
01/01/2008 - 12/31/2008 Ad hoc scientific reviewer for Susan G. Komen for the Cure (TT-1, Target Therapeutics)
01/01/2008 - 10/12/2012 VA, Ad hoc Scientific reviewer for Oncology Study Section and Career Development Pane


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Hou, S., Padmanaban, S., Qi, X., Lepp, A., Mirza, S. P., and Chen, G. p38gamma MAPK signals through phosphorylating its phosphatase PTPH1 in regulating Ras oncogenesis and stress response. J Biol Chem 2012,287: 27895-27950
2. Yusuke, Kobayashi, Xiaomei Qi, and Chen, G. MK2 regulates Ras oncogenesis through stimulating ROS production. Gene & Cancer, 2012 in press
3. Qi, X., Zhi, H., Lepp, A., Wang, P., Huang, J., Basir, Z., Chitambar, C. R., Myers, C. R., and Chen, G. p38gamma mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from the classical to the non-classical pathway via stimulating ER phosphorylation and c-Jun transcription. J Biol Chem 2012, 287: 14681-14691
4. Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G. PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. Oncogene. 2011 Apr 07;30(14):1706-15. PMCID: PMC3072445
5. Qi, X., Hou, S., Lepp, A., Li, R., Basir, Z., Lou, Z., and Chen, G. Phosphorylation and stabilization of topoisomerase II by p38 MAPK sensitize breast cancer cells to its poisons. J Biol Chem 2011, 286: 35883-35890
6. Zhi, H., Hou, S., Li, R., Basir, Z., Xiang, Q., Szabo, A., Chen, G. PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. Oncogene, in press 2011, (this paper was highlighted by TIS, known as the Target Intelligence Service.) https://www.targetintelligenceservice.com/main/public/case.jsp?report_id=43816
7. Hou, S., Lepp, A., Chen, G. (2010) p38gamma MAP kinase (review). UCSD-Nature Molecular Pages 1September 2010 / doi:10.1038/mp.a001720.01
8. Hou, S., Zhi, H., Pohl, N., Loesch, M., Qi, X., Li, R., Basir, Z., and Chen, G. (2010) PTPH1 dephosphorylates and cooperate with p38gamma MAPK to increase Ras oncogenesis through PDZ-mediated interaction. Cancer Res. 70: 2901-2910
9. Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G. PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. Cancer Res. 2010 Apr 01;70(7):2901-10. PMCID: PMC2848905
10. Loesch, M., Zhi, H., Hou, S., Qi, X., Li, R., Basir, Z., Iftner, T., Cuenda, A., and Chen, G. (2010) p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. 2010, J. Biol. Chem. 285: 15149-15158
11. Loesch, M., Chen, G. The p38gamma MAPK stress pathway as a tumor suppressor or more? Front. Biosci., 2008, 13: 3581-3593 (review).
12. Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G. Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity. J Biol Chem. 2007 Jan 19;282(3):1544-51.
13. Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. J Biol Chem. 2007 Oct 26;282(43):31398-408.
14. Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G. p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. Cancer Res. 2006 Aug 01;66(15):7540-7. PMCID: PMC2174269
15. Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G. p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. J Biol Chem. 2012 Aug 10;287(33):27895-905. PMCID: PMC3431700
16. Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G. p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. J Biol Chem. 2012 Aug 10;287(33):27895-905. PMCID: PMC3431700
17. Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G. p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription. J Biol Chem. 2012 Apr 27;287(18):14681-91. PMCID: PMC3340246
18. Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G. PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. Oncogene. 2011 Apr 07;30(14):1706-15. PMCID: PMC3072445
19. Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G. p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. J Biol Chem. 2010 May 14;285(20):15149-15158. PMCID: PMC2865276
20. Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G. PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. Cancer Res. 2010 Apr 01;70(7):2901-10. PMCID: PMC2848905
21. Qi XM, Wang F, Mortensen M, Wertz R, Chen G. Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy. Acta Pharm Sin B. 2018 Jul;8(4):511-517. PMCID: PMC6089844
22. Yin N, Lepp A, Ji Y, Mortensen M, Hou S, Qi XM, Myers CR, Chen G. The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating <i>EGFR</i> transcription and EGFR dephosphorylation. J Biol Chem. 2017 09 08;292(36):15070-15079. PMCID: PMC5592682
23. Chen G, Templeton D, Suttle DP, Stacey DW. Ras stimulates DNA topoisomerase II alpha through MEK: a link between oncogenic signaling and a therapeutic target. Oncogene. 1999 Nov 25;18(50):7149-60.
24. Chen G, Teicher BA, Frei E 3rd. Biochemical characterization of in vivo alkylating agent resistance of a murine EMT-6 mammary carcinoma. Implication for systemic involvement in the resistance phenotype. Cancer Biochem Biophys. 1998 Jun;16(1-2):139-55.
25. Chen G, Shu J, Stacey DW. Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. Oncogene. 1997 Oct 02;15(14):1643-51.
26. Chen G, Teicher BA, Frei E 3rd. Differential interactions of Pgp inhibitor thaliblastine with adriamycin, etoposide, taxol and anthrapyrazole CI941 in sensitive and multidrug-resistant human MCF-7 breast cancer cells. Anticancer Res. 1996 Nov-Dec;16(6B):3499-505.
27. Chen G, Hutter KJ, Zeller WJ. Positive correlation between cellular glutathione and acquired cisplatin resistance in human ovarian cancer cells. Cell Biol Toxicol. 1995 Oct;11(5):273-81.
28. Chen G, Waxman DJ. Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. Biochem Pharmacol. 1995 May 26;49(11):1691-701.
29. Chen G, Waxman DJ. Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. Biochem Pharmacol. 1994 Mar 15;47(6):1079-87.
30. Chen G, Ramachandran C, Krishan A. Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. Cancer Res. 1993 Jun 01;53(11):2544-7.
31. Chen G, Zeller WJ. Reversal of acquired cisplatin resistance by nicotinamide in vitro and in vivo. Cancer Chemother Pharmacol. 1993;33(2):157-62.
32. Chen G, Zeller WJ. Multiple effects of 3-aminobenzamide on DNA damage induced by cisplatin (DDP) in DDP-sensitive and -resistant rat ovarian tumor cell lines. Cancer Lett. 1992 Oct 30;67(1):27-33.
33. Chen G, Zeller WJ. Increased poly(ADP-ribose) formation in cisplatin-resistant rat ovarian tumor cells. Anticancer Res. 1994 Jul-Aug;14(4A):1461-7.
34. Bürkle A, Chen G, Küpper JH, Grube K, Zeller WJ. Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment. Carcinogenesis. 1993 Apr;14(4):559-61.
35. Chen G, Todorov DK, Zeller WJ. Antitumor activity of thaliblastine (NSC-68075) in experimental ovarian tumor cell lines sensitive and resistant to cisplatin. Cancer Lett. 1992 Feb 29;62(2):173-7.
36. Chen G, Zeller WJ. Augmentation of cisplatin (DDP) cytotoxicity in vivo by DL-buthionine sulfoximine (BSO) in DDP-sensitive and-resistant rat ovarian tumors and its relation to DNA interstrand cross links. Anticancer Res. 1991 Nov-Dec;11(6):2231-7.
37. Zeller WJ, Frühauf S, Chen G, Keppler BK, Frei E, Kaufmann M. Chemoresistance in rat ovarian tumours. Eur J Cancer. 1991;27(1):62-7.
38. Chen G, Zeller WJ. Enhancement of cisplatin (DDP) antitumor activity by 3-aminobenzamide in rat ovarian tumors sensitive and resistant to DDP in vivo. Cancer Chemother Pharmacol. 1990;26(1):37-41.
39. Zeller WJ, Frühauf S, Chen G, Eisenbrand G, Lijinsky W. Biological activity of hydroxylated chloroethylnitrosoureas. Cancer Res. 1989 Jun 15;49(12):3267-70.
40. Chen G, Li W. Editorial Preface for Targeted Cancer Therapy Acta Pharmaceutica Sinica B. July 2018;8(4):501-502.
41. Stacey DW, Hitomi M, Chen G. Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity. Mol Cell Biol. 2000 Dec;20(24):9127-37. PMCID: PMC102171
42. Chen G, Baechle A, Nevins TD, Oh S, Harmon C, Stacey DW. Protection against cyclophosphamide-induced alopecia and inhibition of mammary tumor growth by topical 1,25-dihydroxyvitamin D3 in mice. Int J Cancer. 1998 Jan 19;75(2):303-9.
43. Teicher BA, Holden SA, Ara G, Chen G. Transforming growth factor-beta in in vivo resistance. Cancer Chemother Pharmacol. 1996;37(6):601-9.
44. Chen G, Zeller WJ, Todorov DK. Collateral sensitivity to thaliblastine and/or hyperthermia exhibited by a rat ovarian tumor cell line selected for resistance to cisplatin. Anticancer Res. 1993 Sep-Oct;13(5A):1269-75.
45. Chen G, Zeller WJ. Investigations on synergistic effects of BSO and 3AB for the reversal of cisplatin resistance Tumor Diagnostik und Therapie. 1991;12(6):226-229.
46. Chen G, Hutter KJ, Bullerdiek J, Zeller WJ. Karyotypic change from heteroploidy to near diploidy associated with development of cisplatin resistance in a rat ovarian tumour cell line. J Cancer Res Clin Oncol. 1991;117(6):539-42.
47. Chen G, Zeller WJ. In vitro investigations on induction and reversal of cisplatin resistance in a rat ovarian tumor cell line. J Cancer Res Clin Oncol. 1990;116(5):443-7.
48. Chen G, Frei E, Zeller WJ. Determination of intracellular reduced glutathione and glutathione related enzyme activities in cisplatin-sensitive and resistant experimental ovarian carcinoma cell lines. Cancer Lett. 1989 Aug;46(3):207-11.
49. Chen G, Hitomi M. Dissociation of CDK2 from cyclin A in response to the topoisomerase II inhibitor etoposide in v-src-transformed but not normal NIH 3T3 cells. Exp Cell Res. 1999 Jun 15;249(2):327-36.
50. Chen G, Waxman DJ. Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. J Pharmacol Exp Ther. 1995 Sep;274(3):1271-7.
51. Chen G, Pan QC. Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide. Cancer Chemother Pharmacol. 1988;22(4):303-7.
52. Chen G, Oh S, Monia BP, Stacey DW. Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts. J Biol Chem. 1996 Nov 08;271(45):28259-65.
53. Chen G, Zeller WJ. Effects of thaliblastine on cytotoxicity and DNA damage in drug-sensitive and -resistant rat ovarian tumor cells treated with cisplatin. Anticancer Res. 1993 Jan-Feb;13(1):219-23.
54. Chang TK, Chen G, Waxman DJ. Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism. J Pharmacol Exp Ther. 1995 Jul;274(1):270-5.
55. Chen G, Li W. Editorial Preface for Targeted Cancer Therapy. Acta Pharm Sin B. 2018 Jul;8(4):501-502. PMCID: PMC6090083
56. Fang Wang, Xiao-Mei Qi, Ryan Wertz, Matthew Mortensen, Catherine Hagen, John Evans, Yuri Sheinin, Michael James, Pengyuan Liu, Susan Tsai, James Thomas, Alexander Mackinnon, Michael Dwinell, Charles R Myers, Ramon Bartrons, Liwu Fu, Guan Chen. p38gamma MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis Cancer Research. Wang F, Qi XM, Wertz R, et al. p38gamma MAPK is essential for aerobic glycolysis and pancreatic tumorigenesis [published online ahead of print, 2020 Jun 24]. Cancer Res. 2020;canre.
57. Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G. p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Res. 2020 08 15;80(16):3251-3264.
58. Chen G, Pan QC. [Enhancement of the antitumor activity of bleomycin A5 by 3-aminobenzamide in vitro and in vivo]. Yao Xue Xue Bao. 1985 May;20(5):331-3.