CURRICULUM VITAE
Heather A. Himburg PhD
Heather A. Himburg PhD
Associate Professor
Department of Radiation Oncology
Department of Radiation Oncology
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
FACULTY APPOINTMENTS: |
01/01/2021 - Present Secondary Appointment, Biomedical Engineering, Medical College of Wisconsin |
AWARDS AND HONORS: |
2022 - 2023 Top Reviewers, ASTRO Red Journal |
- 2024 JW Osborne Award, Radiation Research Society |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2018 - Present Radiation Research Society (Member) |
10/01/2022 - Present American Society of Radiation Oncology (ASTRO) (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
09/04/2024 - Present Associate Editor, International Journal of Radiation Oncology*Biology*Physics |
Ad-Hoc Reviewer |
Radiation Research |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
03/01/2021 - 01/01/2022 Lung Cancer Clinical Leader Search Committee, Medical College of Wisconsin |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
02/2021 Reviewer, Pilot Project Review, Centers for Medical Countermeasures against Radiation |
04/2021 Reviewer, 2021 The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine, American Association for Cancer Research |
06/23/2022 - 06/24/2022 Reviewer, Cancer Diagnostics and Treatments SBIR/STTR Study Section, NIH |
03/23/2023 - 03/24/2024 Reviewer, Cancer Diagnostics and Treatments (CDT-13) SBIR/STTR study section, NIH |
06/12/2023 - 06/13/2024 Reviewer, Radiation Therapeutics and Biology (RTB) Study Section, NIH |
2024 - 2028 Member, Radiation Therapeutics and Biology Study Section (RTB), National Institutes of Health, Center for Scientific Review |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
Dkk1-Endothelial Progenitor Cell Treatment for the Mitigation of Hematopoietic
Radiation Injury, Cellular Therapies for Treatment of Radiation Injuries (U01)
RFA-AI-17-001
Annual Meeting, Virtual NIAID Radiation/Nuclear Countermeasures Program (RNCP), 12/18/2020 |
Mechanism of Radiation–Induced Endovascular Injury and Mitigation: Role of Dll4/Notch, U01 Annual Investigator Meeting, Virtual NIAIDRadiation/Nuclear Countermeasures Program (RNCP), 01/28/2021 |
The role of ACE/ACE2 signaling in mediating sex-related differences in late radiosensitivity following
partial body irradiation in WAG/RijCmcr rats, 2022 Sex Differences in Radiation Research Workshop, Virtual NIH NIAID/NIH ORWH/BARDA/FDAA Meeting, 04/26/2022 - 04/27/2022 |
Targeting the Renin Angiotensin System for Mitigation, Radiation-Induced Multi-Organ Injury Workshop, NIH/NIAID Virtual Workshop, 06/07/2022 - 06/08/2022 |
Heather Himburg, Pediatric and Geriatric Rats MCMs & Natural History, Understudied Populations in Radiation Exposure Research: Needs,
Challenges, and Mitigation Strategies, Grand Hall, 5601 Fishers Lane, Rockville, MD 20852, 04/10/2024 - 04/11/2024 |
Marjan Boerma, Amrita Cheema, Heather Himburg, Development of a minimally invasive biomarker assay to detect delayed radiation injury, U01 Annual Investigator Meeting
Radiation Biodosimetry Novel Assays and Devices, 5601 Fishers Lane, Rm 1D13, Rockville, MD 20852, 06/27/2024 |
CardioWatch – Rodent Studies, CardioWatch – SBIR Phase II Annual Project Meeting, Fishers Lane, Rockville MD 20852, 06/28/2024 |
Repurposing ACE Inhibitors for the Treatment of Delayed Effects of Acute Radiation Exposure (DEARE), Radiation Injury Treatment Network (RITN), Alexandria, VA, 07/09/2024 - 07/10/2024 |
Repurposing ACE inhibitors for the treatment of delayed effects of acute radiation exposure (DEARE), Radiation Research Society Annual Meeting, Tucson, Arizona, 09/15/2024 - 09/18/2024 |
JW Osborne Award Lecture: Development of medical countermeasures for multi-organ radiation injury, Radiation Research Society Annual Meeting, Tucson, Arizona, 09/15/2024 - 09/18/2024 |
Regional |
Medical Countermeasures for Mitigation of Multi-Organ Radiation Injury, Avioli Musculoskeletal Research Seminar Series, Washington University School of Medicine St. Louis, 05/2024 |
Local |
BDNF Signaling Promotes Hematopoietic Recovery Following Radiation Injury, CVC ATVB Virtual Fall 2020 Signature Program Meeting, MCW, 09/28/2020 |
Pleiotrophin Signaling Regulates Chronic Myeloid Leukemia Pathogenesis, CVC Cardio-Oncology Affinity Group Virtual Meeting, MCW, 11/05/2020 |
Medical Countermeasures for Multi-Organ Radiation-Induced Injuries, Cancer Center Seminar Series - Discovery & Developmental Therapeutics Research Program, MCW, 01/15/2021 |
Mechanism of Radiation–Induced Endovascular Injury and Mitigation: Role of Dll4/Notch, CVC ATVB Virtual Signature Program Meeting, MCW, 01/25/2021 |
Update on NIAID Radiation and Nuclear Countermeasures Program Projects, Radiation Oncology Grand Rounds, Medical College of Wisconsin, 03/17/2021 |
Heather Himburg, Sarah Kerns, From the Bench to Bedside: Careers in Oncology, MCW Cancer Center'sCareers in Clinical Oncology and Cancer Research Symposium, Medical College of Wisconsin, 09/30/2023 |
Dynamic response to radiotherapy: Single-cell transcriptomic response in patients enrolled on the hypofractionated preoperative radiation for head and neck cancer (HyPR-HN) trial, MCW Radiation Oncology Ground Rounds, Virtual, 01/31/2024 |
Heather Himburg, Development of Medical Countermeasures for Multi-Organ Radiation-Induced Injuries, MCW Physiology Department Seminar, 11/10/2024 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
10/2021 - Present Resident Education Committee, Radiation Oncology |
04/2022 - Present member, ROCKET Leadership committee, Radiation Oncology |
MCW TEACHING ACTIVITIES: |
Resident and Fellow Education |
10/01/2021 - Present Radiation Biology Course Director |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
06/01/2021 - 08/05/2021 Eric Yang, Diversity Summer Health-related Education Program (DSHREP), Medical College of Wisconsin, Presentation at Summer Programs Symposium
MCW medical class 2023 |
06/2022 - 08/2022 Angelique Compton, Diversity Summer Health-Related Research Experience, Medical College of Wisconsin, Presentation at DSHREP meeting |
09/2022 - Present Rachel Kuehn, UWM/MCW Cancer Center Undergraduate Program, Medical College of Wisconsin, Awarded UWM/CC Summer Scholarship |
Graduate Students |
PhD Students Advised |
01/12/2024 - Present Austen Nissen, Medical College of Wisconsin, Oral presentation at MCW CC Trainee Symposium |
Postdoctoral Researchers |
01/05/2021 - Present Guru Prasad Sharma, Research Advisor, Medical College of Wisconsin, Awarded Radiation Research Travel Award Oct 2021 Meeting
Awarded Radiation Research Society Editor's Award 2022 |
COMMUNITY SERVICE ACTIVITIES: |
09/2023 - 05/2024 Volunteer faculty advisor to the DSHA High School Students Modeling A Research Topic (SMART) Team |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Li XM, Friedman MH. Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1916-22. |
2. LaMack JA, Himburg HA, Li XM, Friedman MH. Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. Ann Biomed Eng. 2005 Apr;33(4):457-64. |
3. Lamack JA, Himburg HA, Friedman MH. Effect of hypercholesterolemia on transendothelial EBD-albumin permeability and lipid accumulation in porcine iliac arteries. Atherosclerosis. 2006 Feb;184(2):255-63. |
4. Himburg HA, Friedman MH. Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. J Biomech Eng. 2006 Dec;128(6):852-6. |
5. Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ. Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood. 2007 Mar 15;109(6):2365-72. PMCID: PMC1852197 |
6. Himburg HA, Dowd SE, Friedman MH. Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H645-53. |
7. LaMack JA, Himburg HA, Friedman MH. Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. Atherosclerosis. 2007 Dec;195(2):e35-41. PMCID: PMC2683674 |
8. Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 2008 Apr 02;3(4):e1912. PMCID: PMC2271127 |
9. Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol. 2009 Feb;23(2):188-201. PMCID: PMC2646618 |
10. Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP. Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood. 2009 Feb 26;113(9):2104-7. PMCID: PMC2651019 |
11. Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010 Mar 31;28(3):523-34. PMCID: PMC3909217 |
12. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr;16(4):475-82. PMCID: PMC3689427 |
13. LaMack JA, Himburg HA, Zhang J, Friedman MH. Endothelial gene expression in regions of defined shear exposure in the porcine iliac arteries. Ann Biomed Eng. 2010 Jul;38(7):2252-62. |
14. Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One. 2010 Jul 12;5(7):e11535. PMCID: PMC2902517 |
15. Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25;2(4):964-75. PMCID: PMC3696585 |
16. Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells. 2013 Feb;31(2):327-37. PMCID: PMC3580267 |
17. Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013 Mar;19(3):295-304. PMCID: PMC3594347 |
18. Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP. Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest. 2014 Nov;124(11):4753-8. PMCID: PMC4347246 |
19. Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP. A translatable predictor of human radiation exposure. PLoS One. 2014;9(9):e107897. PMCID: PMC4177872 |
20. Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP. Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. J Clin Invest. 2015 Jan;125(1):177-82. PMCID: PMC4382260 |
21. Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut. 2016 Apr;65(4):683-92. PMCID: PMC4504836 |
22. Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. Radiat Res. 2016 Aug;186(2):141-52. PMCID: PMC6016841 |
23. Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP. Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Cell Rep. 2016 Nov 01;17(6):1584-1594. PMCID: PMC5963255 |
24. Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. Nat Med. 2017 Jan;23(1):91-99. PMCID: PMC5592969 |
25. Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP. Wild-type Kras expands and exhausts hematopoietic stem cells. JCI Insight. 2018 Jun 07;3(11). PMCID: PMC6124423 |
26. Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP. Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. Cell Stem Cell. 2018 Sep 06;23(3):370-381.e5. PMCID: PMC6482945 |
27. Kim MM, Schlussel L, Zhao L, Himburg HA. Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. Radiat Res. 2019 Jul;192(1):53-62. PMCID: PMC6668624 |
28. Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. PTPσ inhibitors promote hematopoietic stem cell regeneration. Nat Commun. 2019 Aug 14;10(1):3667. PMCID: PMC6694155 |
29. Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP. Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. J Clin Invest. 2020 Jan 02;130(1):315-328. PMCID: PMC6934217 |
30. Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP. Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration. Blood. 2020 Jul 23;136(4):441-454. PMCID: PMC7378456 |
31. Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M. Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. Health Phys. 2021 Oct 01;121(4):419-433. PMCID: PMC8577554 |
32. Termini CM, Pang A, Fang T, Roos M, Chang VY, Zhang Y, Setiawan NJ, Signaevskaia L, Li M, Kim MM, Tabibi O, Lin PK, Sasine JP, Chatterjee A, Murali R, Himburg HA, Chute JP. Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution. Nat Commun. 2021 Nov 30;12(1):6990. PMCID: PMC8635308 |
33. Sharma GP, Frei AC, Narayanan J, Gasperetti T, Veley D, Amjad A, Albano K, Fish BL, Himburg HA. Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells. PLoS One. 2021;16(10):e0259042. PMCID: PMC8544859 |
34. Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA. Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells. Int J Radiat Oncol Biol Phys. 2022 May 01;113(1):177-191. PMCID: PMC9018504 |
35. Zenga J, Awan MJ, Frei A, Petrie E, Sharma GP, Shreenivas A, Shukla M, Himburg HA. Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model. Head Neck. 2022 Jun;44(6):1324-1334. PMCID: PMC9081149 |
36. Gasperetti T, Sharma GP, Frei AC, Pierce L, Veley D, Szalewski N, Narayanan J, Fish BL, Himburg HA. Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate. Radiat Res. 2022 Oct 01;198(4):325-335. PMCID: PMC9641750 |
37. Sharma GP, Himburg HA. Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure. Toxics. 2022 Dec 01;10(12). PMCID: PMC9781710 |
38. Zenga J, Awan MJ, Frei A, Shukla M, Shreenivas A, Wong SJ, Himburg HA. Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation Oral Oncology Reports. March 2023;5. |
39. Gasperetti T, Frei A, Prasad Sharma G, Pierce L, Veley D, Szalewski N, Munjal Mehta S, Fish BL, Pleimes D, Himburg HA. Delayed renal injury in survivors of hematologic acute radiation syndrome. Int J Radiat Biol. 2023;99(7):1130-1138. PMCID: PMC10313734 |
40. Doan PL, Frei AC, Piryani SO, Szalewski N, Fan E, Himburg HA. Cord Blood-Derived Endothelial Progenitor Cells Promote In Vivo Regeneration of Human Hematopoietic Bone Marrow. Int J Radiat Oncol Biol Phys. 2023 Aug 01;116(5):1163-1174. PMCID: PMC11086728 |
41. Fish BL, Hart B, Gasperetti T, Narayanan J, Gao F, Veley D, Pierce L, Himburg HA, MacVittie T, Medhora M. IPW-5371 mitigates the delayed effects of acute radiation exposure in WAG/RijCmcr rats when started 15 days after PBI with bone marrow sparing. Int J Radiat Biol. 2023;99(7):1119-1129. PMCID: PMC10330589 |
42. Medhora M, Gao F, Gasperetti T, Narayanan J, Himburg H, Jacobs ER, Clough AV, Fish BL, Szabo A. Biomarkers to Predict Lethal Radiation Injury to the Rat Lung. Int J Mol Sci. 2023 Mar 15;24(6). PMCID: PMC10053311 |
43. Bansal S, Bansal S, Fish BL, Li Y, Xu X, Fernandez JA, Griffin JH, Himburg HA, Boerma M, Medhora M, Cheema AK. Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity. Int J Radiat Biol. 2023;99(7):1109-1118. PMCID: PMC10330346 |
44. Sharma GP, Frei A, Fish B, Gasperetti T, Veley D, Szalewski N, Nissen A, Himburg HA. Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury. Front Physiol. 2023;14:1191237. PMCID: PMC10235526 |
45. Zenga J, Awan M, Hadi Razeghi Kondelaji M, Hansen C, Shafiee S, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Joshi A, Himburg HA. Photoactivated HPPH-Liposomal therapy for the treatment of HPV-Negative head and neck cancer. Oral Oncol. 2023 Sep;144:106487. PMCID: PMC10413333 |
46. Sharma G, Razeghi Kondelaji MH, Sharma GP, Hansen C, Parchur AK, Shafiee S, Jagtap JM, Fish B, Bergom C, Paulson E, Hall WA, Himburg HA, Joshi A. X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer. Technol Cancer Res Treat. 2023;22:15330338231189593. PMCID: PMC10363893 |
47. Musaddiq A, Zenga J, Frei A, Shukla ME, Himburg HA. Differential Response to Radiation Fractionation in Head and Neck Cancer Patient-Derived Xenografts. Int J Radiat Oncol Biol Phys. 2023 Oct 01;117(2S):e253. |
48. Bonate R, Paulson ES, Frei A, Shukla ME, Tarima S, Wong S, Himburg HA, Zenga J, Awan MJ. Differential Response in Quantitative MRI Parameters Detected in Head and Neck Cancer Patients Treated with Concurrent Immunotherapy during Hypo-Fractionated MR-gRT. Int J Radiat Oncol Biol Phys. 2023 Oct 01;117(2S):S65. |
49. Kondelaji MHR, Sharma GP, Jagtap J, Shafiee S, Hansen C, Gasperetti T, Frei A, Veley D, Narayanan J, Fish BL, Parchur AK, Ibrahim EH, Medhora M, Himburg HA, Joshi A. 2<sup>nd</sup> Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature. Mol Imaging Biol. 2024 Feb;26(1):124-137. PMCID: PMC11188939 |
50. Sasine JP, Kozlova NY, Valicente L, Dukov J, Tran DH, Himburg HA, Kumar S, Khorsandi S, Chan A, Grohe S, Li M, Kan J, Sehl ME, Schiller GJ, Reinhardt B, Singh BK, Ho R, Yue P, Pasquale EB, Chute JP. Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis. Cancer Res. 2024 Mar 15;84(6):919-934. PMCID: PMC10940855 |
51. Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA. Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. Transl Oncol. 2024 Apr;42:101899. PMCID: PMC10851216 |
52. Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA. Type I interferon signaling promotes radioresistance in head and neck cancer. Transl Cancer Res. 2024 May 31;13(5):2535-2543. PMCID: PMC11170510 |
53. Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ. In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations Oral Oncology. September 2024;156. |
54. Chang VY, He Y, Grohe S, Brady MR, Chan A, Kadam RS, Fang T, Pang A, Pohl K, Tran E, Li M, Kan J, Zhang Y, Lu JJ, Sasine JP, Himburg HA, Yue P, Chute JP. Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells. iScience. 2024 Jul 19;27(7):110306. PMCID: PMC11269946 |
55. Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ. In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations. Oral Oncol. 2024 Sep;156:106947. |
56. Hansen C, Jagtap J, Parchur A, Sharma G, Shafiee S, Sinha S, Himburg H, Joshi A. Dynamic multispectral NIR/SWIR for <i>in vivo</i> lymphovascular architectural and functional quantification. J Biomed Opt. 2024 Oct;29(10):106001. PMCID: PMC11425400 |
57. Wesolowski R, Fish BL, Eibl M, Bähr S, Munjal Mehta S, Czajkowski MT, Gasperetti T, Orschell CM, Asang C, Singh N, Himburg HA, Pleimes D. IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents. Int J Radiat Biol. 2025;101(1):1-14. PMCID: PMC11698650 |
58. Espinosa OV, Awan M, Memon AA, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Shukla M, Kasprzak J, Joshi A, Dwinell M, Himburg HA, Zenga J. Locked Dimerized CXCL12 Exerts Radiosensitizing Effects in Head and Neck Cancer. Head Neck. 2024 Dec 26. |
Books, Chapters, and Reviews |
1. Himburg HA and Chute JP. M Abou-Donia, Editor. Mammalian Toxicology
Chapter 15: Ionizing Radiation: Toxicologic Action. 2017 John Wiley and Sons Ltd., Chichester, West Sussex, UK.
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2. Himburg, HA and Chute JP. Chapter XXV Bone Marrow Transplantation - Animal Models. CMCR- RADIOBIOLOGY AND METHODS PUBLIC TEXTBOOK. Feb 1, 2019. https://pitt.app.box.com/v/CMCR-Virtual-Publications-2018/file/400544143300 |
Editorials, Letters To Editor, Other |
1. Friedman MH, Himburg HA, LaMack JA. Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. J Biomech Eng. 2006 Dec;128(6):965-8. |
2. Chute JP, Himburg HA. Imatinib tackles lymphoma via the PDGFRβ+ pericyte. Blood. 2013 Jun 27;121(26):5107-8. |
3. Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Friedman MH. Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics. J Biomech Eng. 2016 Sep 01;138(9):0955011-2. PMCID: PMC4993249 |
Abstracts |
1. Himburg HA, Lamack JA, Friedman MH. A CFD-based method to evaluate the effect of shear stress on endothelial gene expression in vivo Proceedings of the 2005 Summer Bioengineering Conference. 2005;2005:1392-1393. |
2. LaMack JA, Himburg HA, Li XM, Friedman MH. Model-based shear stress gradient in realistic vascular flows and its relation to arterial macromolecular permeability American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 2003;55:89-90. |
Patents |
1. John P. Chute and Heather Himburg. “Pleiotrophin is a novel growth factor and self-renewal factor for hematopoietic stem cells.” Patent, December 2011 |
