CURRICULUM VITAE
Herve Falet PhD
Herve Falet PhD
Associate Professor
Department of Cell Biology, Neurobiology and Anatomy
Investigator, Versiti Blood Research Institute
Department of Cell Biology, Neurobiology and Anatomy
Investigator, Versiti Blood Research Institute
OFFICE ADDRESS: |
The Blood Research Institute |
Versiti Inc |
Milwaukee, WI 53226 |
Phone: 414-937-3870 |
Email: hfalet@mcw.edu |
EDUCATION: |
10/1992 - 09/1993 MS, Molecular Pharmacology, Paris Descartes University |
10/1993 - 01/1997 PhD, Molecular and Cellular Biology, Paris Descartes University |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/1992 - 09/1993 MSc Student, Inserm U428 |
10/1993 - 01/1997 PhD Candidate, Inserm U428 |
02/1997 - 05/1997 Postdoctoral Researcher, Inserm U428 |
06/1997 - 08/2001 Postdoctoral Researcher, Brigham and Women’s Hospital and Harvard Medical School |
FACULTY APPOINTMENTS: |
09/2001 - 07/2016 Instructor, Department of Medicine, Harvard Medical School |
07/2016 - 06/2020 Assistant Professor, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin |
08/2016 - 06/2017 Associate Investigator, Versiti Blood Research Institute |
07/2017 - Present Investigator, Versiti Blood Research Institute |
07/2020 - Present Associate Professor, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
09/2001 - 07/2016 Associate Biologist, Division of Hematology, Brigham and Women’s Hospital |
02/2024 - Present Member, Cardiovascular Center, Medical College of Wisconsin |
04/2024 - Present Member, Cancer Center, Medical College of Wisconsin |
AWARDS AND HONORS: |
1993 Cum Laude, Paris Descartes University |
1993 - 1996 Fellowship, Ministry of Higher Education and Research, France |
1996 - 1997 Fellowship, Foundation for Medical Research, France |
1997 Summa Cum Laude, Paris Descartes University |
1998 Outstanding PhD Dissertation Award, Paris Descartes University |
2014 Plenary Presentation, Best of ASH in Hemostasis and Thrombosis, Best of ASH, American Society of Hematology Meeting, San Francisco, CA |
2015 - 2016 Bridge Grant Award, BWH Brigham Research Institute, Boston, MA |
2015 Highlights of ISTH, International Society on Thrombosis and Haemostasis Congress, Toronto, Canada |
2015 Best of ASH in Hemostasis and Thrombosis, American Society of Hematology Meeting, Orlando, FL |
2015 - 2016 Bridge Grant Award, American Society of Hematology, Washington, DC |
2016 - 2020 R01 HL126743 Grant Award, NIH National Heart, Lung, and Blood Institute, Bethesda, MD |
2018 Outstanding Graduate School Educator Award, Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI |
2018 Winner, Platelets Journal Cover Competition |
2022 Outstanding Graduate School Educator Award, Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2001 - Present American Society of Hematology (Member) |
2002 - Present International Society on Thrombosis and Haemostasis (Member) |
2013 American Heart Association (Member) |
2013 - 2019 North American Society on Thrombosis and Hemostasis (Member) |
2017 - 2022 American Society for Cell Biology (Member) |
2019 - 2020 American Chemical Society (Member) |
2019 - 2020 Hemostasis and Thrombosis Research Society (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2021 - Present Journal of Thrombosis and Haemostasis |
Journal Review |
Blood VTH |
Scientific Reports |
Biomaterials |
Journal of Thrombosis and Haemostasis |
Arteriosclerosis, Thrombosis, and Vascular Biology |
PLOS ONE |
Platelets |
Cardiovascular Research |
Journal of Allergy and Clinical Immunology |
Blood Advances |
Journal of Biological Chemistry |
Journal of Proteome Research |
Nature Metabolism |
Blood |
Haematologica |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2018 - Present Member, Institutional Animal Care and Use Committee, Medical College of Wisconsin, Milwaukee, WI |
2018 - 2023 Member, Faculty Search Committee, Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI |
2022 - Present Chair, Communications Committee, Versiti Blood Research Institute, Milwaukee, WI |
2022 - Present Co-Chair, Hematopoiesis Faculty Search Committee, Versiti Blood Research Institute, Milwaukee, WI |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2013 Abstract Reviewer, ASH Meeting, New Orleans, LA, American Society of Hematology |
2014 Coordinating Abstract Reviewer, Scientific Session Moderator, ASH Meeting, San Francisco, CA, American Society of Hematology |
2018 Co-Chair, Thrombosis and Hemostasis Summit of North America, San Diego, CA, Abstract Committee, North American Society on Thrombosis and Hemostasis |
2019 - 2023 Chair, Scientific Committee on Megakaryocytes and Platelets, American Society of Hematology |
2019 Abstract Reviewer, ASH Meeting, New Orleans, LA, North American Society on Thrombosis and Hemostasis |
2019 Abstract Reviewer, ASH Meeting, Orlando, FL, American Society of Hematology |
2021 Scientific Session Moderator, HTRS Virtual Scientific Symposium, Hemostasis and Thrombosis Research Society |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2003 Grant Review, North West Cancer Research, United Kingdom |
2005 Grant Review, Health Research Council, New Zealand |
2005 Scientific Session Moderator, ISTH Congress, Sydney, Australia, International Society on Thrombosis and Haemostasis |
2005 Grant Review, Health Research Board, Ireland |
2013 Scientific Session Moderator, ISTH Congress, Amsterdam, Netherlands, International Society on Thrombosis and Haemostasis |
2013 Grant Review, Health Research Board, Ireland |
2016 Grant Review, Swiss National Science Foundation, Switzerland |
2017 Grant Review, Foundation for Medical Research, France |
2017 Scientific Session Moderator, ISTH Congress, Berlin, Germany, International Society on Thrombosis and Haemostasis |
2017 Grant Review, National Research Agency, France |
2021 - 2024 Co-Chair, Scientific and Standardization Subcommittee on Platelet Physiology, International Society on Thrombosis and Haemostasis |
2021 Scientific Session Moderator, ISTH Virtual Congress, International Society on Thrombosis and Haemostasis |
2022 Scientific Session Moderator, ISTH Congress, London, England, International Society on Thrombosis and Haemostasis |
2023 Abstract Reviewer, ISTH Congress, Montreal, Canada, International Society on Thrombosis and Haemostasis |
2023 Power Hour Session Moderator, GRC on the Cell Biology of Megakaryocytes and Platelets, Barga, Italy, Gordon Research Conferences |
2024 Abstract Reviewer, ISTH Congress, Bangkok, Thailand, International Society on Thrombosis and Haemostasis |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Role of SLP-76 in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex, Research Seminar, Division of Hematology, Brigham and Women’s Hospital, Boston, MA, 2000 |
Role of WIP in platelet activation, Program Project Presentation, Center for Blood Research, Harvard Medical School, Boston, MA, 2000 |
Role of WASp in platelet signaling and clearance, Program Project Presentation, Center for Blood Research, Harvard Medical School, Boston, MA, 2003 |
Unraveling the mysteries of platelet clearance, Program Project Presentation, Division of Immunology, Boston Children’s Hospital, Boston, MA, 2011 |
Endocytosis in thrombopoiesis and bone marrow homeostasis, Grand Rounds Presentation, Division of Hematology, Brigham and Women’s Hospital, Boston, MA, 2015 |
Endocytosis in platelet and megakaryocyte biology, Research Seminar, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 2016 |
Dynamin 2-dependent endocytosis in platelet and megakaryocyte biology, Research Seminar, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 2017 |
Endocytosis in platelet and megakaryocyte biology, Research Retreat Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2018 |
Role of the F-BAR protein PACSIN2 in platelets and megakaryocytes, Research Seminar, Versiti Blood Research Institute, Milwaukee, WI, 2019 |
Super-resolution microscopy in blood research, Focus on Technology Seminar Series Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2019 |
Dynamin 2-dependent endocytosis in platelet and megakaryocyte biology, Research Seminar, Versiti Blood Research Institute, Milwaukee, WI, 2020 |
Dynamin 2 and Mpl in bone marrow systems biology, Bone Marrow Environment Interest Group Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2021 |
Role of PACSIN2 in megakaryocytes and platelets, Thrombosis and Hemostasis Program Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2022 |
Intertwined signaling and endocytic pathways in the megakaryocyte/platelet lineage, Research Seminar, Versiti Blood Research Institute, Milwaukee, WI, 2022 |
National |
Membrane tubulation and fission in platelets and megakaryocytes, Invited Lecture, Puget Sound Blood Center Research Institute, Seattle, WA, 2014 |
Membrane tubulation and fission in platelets and megakaryocytes, Invited Lecture, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, 2014 |
Dynamin 2-dependent endocytosis in megakaryocyte and platelet biology, Scientific Session Presentation, American Association of Blood Banks Meeting, Philadelphia, PA, 2014 |
Endocytosis in megakaryocyte development, Invited Lecture, Bloodworks Northwest Research Institute, Seattle, WA, 2015 |
International |
Role of the protein tyrosine phosphatase PTP1C in platelet activation, Invited Lecture, Laboratory of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain, 1996 |
Role of SLP-76 in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex, Invited Lecture, INSERM U428, Faculty of Pharmacy, Paris Descartes University, Paris, France, 1999 |
Differential roles of WASp and filamin A in platelet function, Invited Lecture, Division of Hematology/Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan, 2006 |
Role of filamin A and PACSIN2 in platelets and megakaryocytes, Invited Lecture, Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany, 2012 |
Receptor-mediated endocytosis in megakaryocyte development, Invited Lecture, Centre for Blood Research, University of British Columbia, Vancouver, Canada, 2015 |
Endocytosis and Mpl/JAK2 signaling in megakaryocytes and myelofibrosis, Scientific Session Presentation, Gordon Research Conference on Hemostasis, Stowe, VT, 2016 |
Raising the BAR: Role of PACSIN2 in platelets and megakaryocytes, Blood and Bone Seminar Series Presentation, Harvard Medical School, Boston, MA, 2020 |
Mpl Endocytosis in Megakaryocyte Homeostasis, Scientific Session Presentation, Gordon Research Conference on the Cell Biology of Megakaryocytes and Platelets, Barga, Italy, 2023 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
Eaton N, Dlugi T, Drew C, Wieser J, Lee-Sundlov M, Dahms N, Hoffmeister KM, Falet H, M6PR-specific targeting of lysosomal enzymes regulates platelet production and function in mice, Great Lakes Translational Glycomics Symposium, Milwaukee, WI, 2018 |
Dlugi T, Eaton N, Wieser J, Lee-Sundlov M, Rivadeneyra L, Dahms N, Hoffmeister KM, Falet H, Loss of mannose-6-phosphate receptor in mice alters hematopoietic stem and progenitor cell population and causes abnormal megakayocyte maturation, Great Lakes Translational Glycomics Symposium, Milwaukee, WI, 2019 |
National |
Robert C, Cheng G, Fuhlbrigge RC, Wong TH, Falet H, von Andrian UH, Kupper TS, Targeting cultured dendritic cells to peripheral lymph nodes using a platelet bridge, Society for Investigative Dermatology Meeting, Cleveland, OH, 1999 |
Hoffmeister KM, Falet H, Barkalow KL, Stossel TP, Hartwig JH, Actin assembly is not related to small GTPases in chilled platelets, American Heart Association Scientific Sessions, New Orleans, LA, 2000 |
Kettner A, Pivniouk VI, Falet H, Lee JS, Kumar L, Geha RS, The role of SLP-76 domains in signaling via the high-affinity IgE receptor (FcεRI) in mast cells, American Academy of Allergy, Asthma and Immunology Meeting, New Orleans, LA, 2001 |
Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Wagner DD, von Andrian UH, Stossel TP, Hartwig JH, Mechanism for rapid clearance of transfused chilled platelets, American Society of Hematology Meeting, Orlando, FL, 2001 |
Falet H, Gallego L, Geha RS, Hartwig JH, Impaired signaling by the collagen receptor GPVI in platelets lacking WIP, American Society of Hematology Meeting, San Diego, CA, 2003 |
Falet H, Marchetti MP, Hoffmeister KM, Italiano JE Jr, Feng Y, Stossel TP, Kwiatkowski DJ, Walsh CA, Hartwig JH, Impaired viability, platelet survival, morphology and function in mice lacking filamin A, American Society of Hematology Meeting, Orlando, FL, 2006 |
Rumjantseva V, Sørensen AL, Hoffmeister KM, Falet H, Sialic acid deficiency impairs GPVI-mediated platelet activation in ST3Gal-IV–/– mice, American Society of Hematology Meeting, New Orleans, LA, 2009 |
Falet H, Pollitt AY, Duerschmied D, Weber SE, Wagner DD, Watson SP, Hartwig JH, FlnA deficiency in platelets reveals functional impairment in ITAM-based signaling, American Society of Hematology Meeting, New Orleans, LA, 2009 |
Grozovsky R, Begonja AJ, Hartwig JH, Falet H, Hoffmeister KM, The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling in vivo and in vitro, American Society of Hematology Meeting, San Francisco, CA, 2014 |
Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Kahr WHA, Hoffmeister KM, Falet H, Dynamin 2-dependent endocytosis regulates megakaryopoiesis, American Society of Hematology Meeting, San Francisco, CA, 2014 |
Giannini S, Bender M, Pluthero FG, Christensen H, Leung R, Lo RW, Kormann J, Plomann M, Kahr WHA, Falet H, Dynamin 2 (DNM2) and PACSIN2 regulate megakaryocyte demarcation membrane system formation and platelet production in concert, American Society of Hematology Meeting, Orlando, FL, 2015 |
Stolla M, Grozovsky R, Lee-Sundlov MM, Falet H, Hoffmeister KM, Effects of platelet circulatory age on platelet function, American Society of Hematology Meeting, San Diego, CA, 2016 |
Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H, Bleeding diathesis in mice lacking JAK2 in platelets, American Society of Hematology Virtual Meeting, 2020 |
Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H, Bleeding diathesis in mice lacking JAK2 in platelets, Hemostasis and Thrombosis Research Society Virtual Scientific Symposium, 2021 |
International |
Falet H, Rendu F, Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets, Erfurt Conference on Platelets (Receptors, Adhesion Molecules and Signalling), Erfurt, Germany, 1994 |
Rendu F, Falet H, Ramos Morales F, Bachelot C, Fischer S, PTP1C is phosphorylated on tyrosine and binds c-Src during thrombin-induced platelet activation, International Conference on Messengers and Phosphoproteins (Signal Transduction in Health and Disease), Nashville, TN, 1995 |
Rendu F, Falet H, Bachelot C, Involvement of the tyrosine protein phosphatase PTP1C in platelet activation, European Thrombosis Research Organization Working Party on Platelet Signal Transduction, Ulvik, Norway, 1996 |
Rendu F, Bachelot C, Saffroy R, Falet H, Lasne D, Receptors and signaling systems involved in immunological platelet activation, Erfurt Conference on Platelets (Platelet Activation in Vascular Disease: Detection, Clinical Significance and Treatment), Erfurt, Germany, 1996 |
Falet H, Rendu F, Study of the protein tyrosine phosphatase 1C during A23187-induced platelet activation, International Congress on Thrombosis, Montpellier, France, 1996 |
Felbinger TW, Hoffmeister KM, Falet H, Wagner DD, Hartwig JH, von Andrian UH, A mechanism for rapid clearance of transfused cooled platelets, World Congress for Microcirculation, Sydney, Australia, 2001 |
Falet H, Geha RS, Hartwig JH, The WIP-WASp complex modulates platelet signaling and function, International Society on Thrombosis and Haemostasis Congress, Sydney, Australia, 2005 |
Dyson JM, Ooms LM, Brown S, Becanovic J, Falet H, Hartwig JH, Berndt MC, Mitchell CA, The platelet actin cytoskeleton dynamically reorganizes into podosomes upon cell adhesion. Identification of a novel actin-rich adhesive structure in human platelets, International Society on Thrombosis and Haemostasis Congress, Sydney, Australia, 2005 |
Jönsson T, Begonja AJ, Bender M, Kormann J, Pluthero FG, Kahr WH, Hartwig JH, Plomann M, Falet H, Functional regulation of platelet membrane systems by the F-BAR protein PACSIN2, International Society on Thrombosis and Haemostasis Congress, Amsterdam, Netherlands, 2013 |
Begonja AJ, Falet H, Hartwig JH, Filamin A stabilizes thrombopoietin receptor surface expression and inhibits its degradation, European Platelet Network Conference, Bischoffsheim, France, 2014 |
Giannini S, Pluthero FG, Christensen H, Leung R, Lo RW, Kormann J, Kahr WHA, Hoffmeister KM, Falet H, Receptor-mediated endocytosis is required for normal megakaryocyte demarcation membrane system formation and platelet production, International Society on Thrombosis and Haemostasis Congress, Toronto, Canada, 2015 |
Lee-Sundlov MM, Ramsey HE, Wood SN, Dickey RJ, Sola-Visner M, Hoffmeister KM, Falet H, Endocytosis of the thrombopoietin receptor Mpl regulates both megakaryocyte and erythroid progenitors and is critical for myelofibrosis development, Gordon Research Conference on the Cell Biology of Megakaryocytes and Platelets, Barga, Italy, 2017 |
Giannini S, Heijnen HFG, Legan E, Hoffmeister KM, Falet H, Clathrin-mediated endocytosis is required for normal platelet hemostatic function, International Society on Thrombosis and Haemostasis Congress, Berlin, Germany, 2017 |
Eaton N, Dlugi T, Drew C, Wieser J, Lee-Sundlov M, Rivadeneyra L, Hoffmeister K, Falet H, M6PR-specific targeting of lysosomal enzymes regulates platelet production, International Society on Thrombosis and Haemostasis Congress, Melbourne, Australia, 2019 |
Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM, Novel GNE gene variants associated with severe congenital thrombocytopenia and platelet sialylation defect - follow up data after hematopoietic stem cell transplantation, International Society on Thrombosis and Haemostasis Congress, London, England, 2022 |
Biswas R, Eaton N, Schulte ML, Plomann M, Hoffmeister KM, Falet H, PACSIN2 regulates platelet integrin β1 hemostatic function, International Society on Thrombosis and Haemostasis Congress, London, England, 2022 |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Graduate Student Education |
2016 - Present Faculty, Graduate School, Interdisciplinary Doctoral Program in Biomedical Sciences (IDP), Cell and Developmental Biology Program |
2018 - Present Faculty, Research Opportunity for Academic Development in Science |
2018 Advanced Cell Biology Course: endocytosis and role in cell regulation, Cell and Developmental Biology Program |
2020 Advanced Cell Biology Course: Endocytosis, Cell and Developmental Biology Program |
2022 Advanced Cell Biology Course: Endocytosis, Cell and Developmental Biology Program |
2023 Responsible Conduct of Research Session Moderator: Peer review, Cell and Developmental Biology Program |
2024 Advanced Cell Biology Course: Understanding Actin Assembly, Cell and Developmental Biology Program |
EXTRAMURAL TEACHING: |
Community/Lay Public |
2001 - 2006 Division of Hematology, Brigham and Women’s Hospital, Webmaster |
2022 - Present Versiti Blood Research Institute, Social Media Manager |
Graduate Student Education |
1989 - 1991 Computer Science Center, University of Poitiers, Teaching Assistant |
2016 - 2020 Versiti Blood Research Institute, Faculty, Training Program T32 HL007209, Research Training in Transfusion Medicine |
2016 - Present Versiti Blood Research Institute, Faculty |
2017 ISTH Academy, Webinar: platelet function testing, mechanisms of testing and clinical implications: mean platelet volume |
2018 - 2023 Versiti Blood Research Institute, Faculty, Career Development Program K12 HL141954, Glycans in Blood Homeostasis and Disease |
2018 Versiti Blood Research Institute, Responsible Conduct of Research Session: Conflict of interest |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
PhD |
Nathan Eaton, Medical College of Wisconsin, 2017 - 2021 |
Emily Boyd, Medical College of Wisconsin, 2022 - Present |
MS |
Demetra Korkos, Medical College of Wisconsin, 2019 |
Allison Gerk, Medical College of Wisconsin, 2021 |
PhD Committees |
Anusha Rengarajan, Medical College of Wisconsin, 2022 - Present |
Hongyin Yu, Medical College of Wisconsin, 2023 - Present |
Faculty |
Mitchell Dyer, Medical College of Wisconsin, 2023 - Present |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
Nina Smolyar, Boston Latin School, 1997 |
Lazaro Vergara, Marquette University High School, 2018 |
Lucia Rondini, University School of Milwaukee, 2019 |
Anastasia Finley, University School of Milwaukee, 2023 |
Undergraduate Students |
Aileen Tiro, Boston University, 1999 - 2000 |
Silke Ebbing, Ruhr University Bochum, 2002 |
Delphine Simon, LaSalle Beauvais Polytechnic Institute, 2007 |
Olivia Gaumétou, LaSalle Beauvais Polytechnic Institute, 2007 |
Thomas Bertin, LaSalle Beauvais Polytechnic Institute, 2008 |
Max Adelman, Cornell University, 2009 |
Guillaume Sertour, LaSalle Beauvais Polytechnic Institute, 2009 |
Emily Legan, Marquette University, 2017 |
Eric Fellin, Marquette University, 2018 |
Gabrielle Gooding, University of Wisconsin–Milwaukee, 2023 |
Medical Students |
Gregory Chang, Harvard Medical School, 2000 - 2002 |
Harry Gebhard, Ludwig Maximilian University Munich, 2004 |
Amalie Dahl Haue, University of Copenhagen, 2013 |
Graduate Students |
MS |
Marc-Olivier Nallet, Paris Descartes University, 1994 - 1995 |
Sabine Pain, Paris Descartes University, 1995 - 1996 |
Abdelhafid Saci, Paris Descartes University, 1996 - 1997 |
Anna Hendeby, University of Gothenburg, 2005 |
Galia Askarieh, University of Gothenburg, 2006 |
Terese Jönsson, University of Gothenburg, 2010 |
Shabnam Rezaie-Aval, University of Gothenburg, 2011 |
Julia Sjödin, University of Gothenburg, 2012 |
Nadia Jaber, University of Gothenburg, 2013 |
Behshte Azizi, University of Gothenburg, 2013 |
Emel Ahmet, University of Gothenburg, 2014 |
PhD |
Emma Josefsson, University of Gothenburg, 2003 - 2007 |
Viktoria Rumjantseva, University of Gothenburg, 2005 - 2009 |
Clinical/Research Fellows |
Antonija Jurak Begonja, University of Rijeka, 2007 - 2014 |
Renata Grozovsky, Harvard Medical School, 2009 - 2014 |
Silvia Giannini, Harvard Medical School, 2010 - 2015 |
Hugh Kim, University of British Columbia Centre for Blood Research, 2011 - 2013 |
Markus Bender, University Hospital Würzburg, 2012 - 2014 |
Melissa Lee-Sundlov, Versiti Blood Research Institute, 2015 - 2022 |
Leonardo Rivadeneyra, Versiti Blood Research Institute, 2017 - 2022 |
Waseem Anani, Versiti Medical Sciences Institute, 2018 - 2020 |
Ratnashree Biswas, Versiti Blood Research Institute, 2019 - 2024 |
Daniel Afosah, Virginia Commonwealth University, 2023 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Falet H, Rendu F. Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets. FEBS Lett. 1994 May 23;345(1):87-91. |
2. Lasne D, Donato J, Falet H, Rendu F. Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction. Thromb Haemost. 1995 Nov;74(5):1323-8. |
3. Si-Tahar M, Renesto P, Falet H, Rendu F, Chignard M. The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin. Biochem J. 1996 Jan 15;313 ( Pt 2)(Pt 2):401-8. PMCID: PMC1216922 |
4. Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F. Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets. FEBS Lett. 1996 Apr 01;383(3):165-9. |
5. Falet H, Pain S, Rendu F. Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. Biochem Biophys Res Commun. 1998 Nov 09;252(1):51-5. |
6. Pain S, Monstero-Lastres A, Falet H, Brohard-Bohn B, Fraiz N, Bachelot-Loza C, Cano E, Rendu F. Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation. FEBS Lett. 1999 Jun 18;453(1-2):119-23. |
7. Pain S, Falet H, Saci A, Bachelot-Loza C, Rendu F. Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. Cell Signal. 2000 Mar;12(3):165-71. |
8. Eaton N, Drew C, Wieser J, Munday AD, Falet H. Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. Haematologica. 2020 May;105(5):1414-1423. PMCID: PMC7193499 |
9. Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01;96(12):3786-92. |
10. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 06;276(27):24751-9. |
11. Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12;155(4):511-7. PMCID: PMC2198874 |
12. Falet H, Hoffmeister KM, Neujahr R, Hartwig JH. Normal Arp2/3 complex activation in platelets lacking WASp. Blood. 2002 Sep 15;100(6):2113-22. |
13. Falet H, Hoffmeister KM, Neujahr R, Italiano JE Jr, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16782-7. PMCID: PMC139221 |
14. Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA. Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. Thromb Res. 2002 Sep 01;107(5):245-54. |
15. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10;112(1):87-97. |
16. Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15;101(12):4789-96. |
17. Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol. 2003 Apr;23(7):2395-406. PMCID: PMC150723 |
18. Barkalow KL, Falet H, Italiano JE Jr, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH. Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct;285(4):C797-805. |
19. Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM. Platelet moesin interacts with PECAM-1 (CD31). Platelets. 2003 Jun;14(4):211-7. |
20. Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec;15(12):1431-40. |
21. Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02;199(3):357-68. PMCID: PMC2211794 |
22. Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH. Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005 Oct;289(4):C819-25. |
23. Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 08;102(45):16263-8. PMCID: PMC1283463 |
24. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun;7(6):1019-28. PMCID: PMC3242443 |
25. Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19;114(21):4729-37. PMCID: PMC2780308 |
26. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30;207(9):1967-79. PMCID: PMC2931168 |
27. Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011 Aug 25;118(8):2285-95. PMCID: PMC3162356 |
28. Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP. Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011;6(7):e21615. PMCID: PMC3136926 |
29. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02;119(5):1263-73. PMCID: PMC3277358 |
30. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. PMCID: PMC3327460 |
31. Kim H, Falet H, Hoffmeister KM, Hartwig JH. Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. J Biol Chem. 2013 Nov 29;288(48):34352-63. PMCID: PMC3843050 |
32. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 04;5:4746. |
33. Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015 Feb 05;125(6):1014-24. PMCID: PMC4319232 |
34. Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan;21(1):47-54. PMCID: PMC4303234 |
35. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2015 Mar 06;6:6507. PMCID: PMC4400601 |
36. Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02;126(1):80-8. PMCID: PMC4492198 |
37. Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM. Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. PMCID: PMC5407363 |
38. Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK. Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01;113(11):1307-1317. PMCID: PMC5852540 |
39. Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, Falet H, Balduini A, Hoffmeister KM. β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. Nat Commun. 2020 Jan 17;11(1):356. PMCID: PMC6968998 |
40. Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM. Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. Haematologica. 2021 Jul 01;106(7):1968-1978. PMCID: PMC8252961 |
41. Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H. Bleeding diathesis in mice lacking JAK2 in platelets. Blood Adv. 2021 Aug 10;5(15):2969-2981. PMCID: PMC8361459 |
42. Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM. Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect. Thromb Haemost. 2022 Jul;122(7):1139-1146. PMCID: PMC10064489 |
43. Eaton N, Boyd EK, Biswas R, Lee-Sundlov MM, Dlugi TA, Ramsey HE, Zheng S, Burns RT, Sola-Visner MC, Hoffmeister KM, Falet H. Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. Front Oncol. 2022;12:959806. PMCID: PMC9468709 |
44. Golla K, Paul M, Lengyell TC, Simpson EM, Falet H, Kim H. A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion. Res Pract Thromb Haemost. 2023 May;7(4):100019. PMCID: PMC10394388 |
45. Biswas R, Boyd EK, Eaton N, Steenackers A, Schulte ML, Reusswig F, Yu H, Drew C, Kahr WHA, Shi Q, Plomann M, Hoffmeister KM, Falet H. PACSIN2 regulates platelet integrin β1 hemostatic function. J Thromb Haemost. 2023 Dec;21(12):3619-3632. PMCID: PMC10841284 |
Books, Chapters, and Reviews |
1. Bachelot C, Falet H, Rendu F. Platelet receptors and mechanisms of activation. Sang Thrombose Vaisseaux. 1995;7(1):39-44 (French) |
2. Barkalow KL, Falet H, Hartwig JH. Dynamics of the platelet cytoskeleton. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Gresele P, Page CP, Fuster V, Vermylen J, Editors. Cambridge University Press; 2002. pp.93-103 |
3. Hoffmeister KM, Falet H. Platelet glycoproteins as lectins in hematology. In: The Sugar Code: Fundamentals of Glycosciences. Gabius HJ, Editor. Wiley-Blackwell; 2009. pp.485-493 |
4. Grozovsky R, Hoffmeister KM, Falet H. Novel clearance mechanisms of platelets. Curr Opin Hematol. 2010 Nov;17(6):585-9. PMCID: PMC4303238 |
5. Falet H. New insights into the versatile roles of platelet FlnA. Platelets. 2013;24(1):1-5. PMCID: PMC6781629 |
6. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Molecular mechanisms regulating platelet clearance and thrombopoietin production. ISBT Science Series. 2015;10(S1):309-316 |
7. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Novel mechanisms of platelet clearance and thrombopoietin regulation. Curr Opin Hematol. 2015 Sep;22(5):445-51. PMCID: PMC5326579 |
8. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Regulating billions of blood platelets: glycans and beyond. Blood. 2015 Oct 15;126(16):1877-84. PMCID: PMC4608239 |
9. Li R, Hoffmeister KM, Falet H. Glycans and the platelet life cycle. Platelets. 2016 Sep;27(6):505-11. PMCID: PMC5396182 |
10. Hoffmeister KM, Falet H. Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance. Thromb Res. 2016 May;141 Suppl 2(Suppl 2):S68-72. PMCID: PMC5399515 |
11. Falet H. Anatomy of the platelet cytoskeleton. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Gresele P, Kleiman NS, López JA, Page CP, Editors. Springer; 2017. pp.139-156 |
12. Giannini S, Falet H, Hoffmeister KM. Platelet glycobiology and the control of platelet function and lifespan. In: Platelets. Michelson AD, Cattaneo M, Frelinger AL, Newman PJ, Editors. Academic Press; 2019. pp.79-97 |
13. Falet H, Rivadeneyra L, Hoffmeister KM. Clinical impact of glycans in platelet and megakaryocyte biology. Blood. 2022 Jun 02;139(22):3255-3263. PMCID: PMC9164739 |
14. Rivadeneyra L, Falet H, Hoffmeister KM. Circulating platelet count and glycans. Curr Opin Hematol. 2021 Nov 01;28(6):431-437. PMCID: PMC8641398 |
15. Lee-Sundlov MM, Rivadeneyra L, Falet H, Hoffmeister KM. Sialic acid and platelet count regulation: Implications in immune thrombocytopenia. Res Pract Thromb Haemost. 2022 Mar;6(3):e12691. PMCID: PMC8994053 |
16. De Silva E, Hong F, Falet H, Kim H. Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton. Front Mol Biosci. 2022;9:1060361. PMCID: PMC9808056 |
Editorials, Letters to Editor, Other |
1. Falet H. Platelet size: finding the right balance. Blood. 2012 Mar 22;119(12):2702-3. |
2. Falet H. Sitosterolemia: platelets on high-sterol diet. Blood. 2013 Oct 10;122(15):2534-5. PMCID: PMC3795455 |
3. Bender M, Falet H. Post-translational arginylation as a novel regulator of platelet function. Haematologica. 2014 Mar;99(3):402-4. PMCID: PMC3943301 |
4. Grozovsky R, Falet H, Hoffmeister KM. Desialylated platelets: a missing link in hepatic thrombopoietin regulation. The Hematologist. 2015;12(3):6-7 |
5. Falet H. Singling out FLI1 in Paris-Trousseau syndrome. Blood. 2017 Jun 29;129(26):3399-3401. PMCID: PMC5492094 |
6. Boyd EK, Falet H. MAGT1 mutant platelets unveiled. J Thromb Haemost. 2023 Nov;21(11):3075-3077. |
