CURRICULUM VITAE
Herve Falet PhD
Herve Falet PhD
Associate Professor
Department of Cell Biology Neurobiology and Anatomy
Investigator, Versiti Blood Research Institute
Department of Cell Biology Neurobiology and Anatomy
Investigator, Versiti Blood Research Institute
OFFICE ADDRESS: |
8727 Watertown Plank Road |
Milwaukee, WI 53226 |
Phone: +1 (414) 9373870 |
Email: hfalet@mcw.edu |
EDUCATION: |
10/1992 - 09/1993 MS, Molecular Pharmacology, Paris Descartes University, Paris, France |
10/1993 - 01/1997 PhD, Molecular and Cellular Biology, Paris Descartes University, Paris, France |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/1992 - 09/1993 MSc Student, Inserm Unit 428, Paris, France |
10/1993 - 01/1997 PhD Candidate, Inserm Unit 428, Paris, France |
02/1997 - 05/1997 Postdoctoral Researcher, Inserm Unit 428, Paris, France |
06/1997 - 08/2001 Postdoctoral Researcher, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA |
FACULTY APPOINTMENTS: |
09/2001 - 07/2016 Instructor, Department of Medicine, Harvard Medical School, Boston, MA |
07/2016 - 06/2020 Assistant Professor, Department of Cell Biology, Neurobiology, and Anatomy (CBNA), Medical College of Wisconsin, Milwaukee, WI |
08/2016 - 06/2017 Associate Investigator, Versiti Blood Research Institute, Milwaukee, WI |
07/2017 - Present Investigator, Versiti Blood Research Institute, Milwaukee, WI |
07/2020 - Present Associate Professor, Department of Cell Biology, Neurobiology, and Anatomy (CBNA), Medical College of Wisconsin, Milwaukee, WI |
CENTER/INSTITUTE AFFILIATIONS: |
02/01/2024 - Present Member, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI |
04/01/2024 - Present Member, Cancer Center, Medical College of Wisconsin, Milwaukee, WI |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
09/2001 - 07/2016 Associate Biologist, Division of Hematology, Brigham and Women’s Hospital, Boston, MA |
AWARDS AND HONORS: |
1993 - 1996 Fellowship, Ministry of Higher Education and Research, France |
1996 - 1997 Fellowship, Foundation for Medical Research, France |
2018 Outstanding Graduate School Educator Award, Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI |
2022 Outstanding Graduate School Educator Award, Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI |
2024 Outstanding Graduate School Educator Award, Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, WI |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2001 - Present American Society of Hematology (ASH) (Member) |
2002 - Present International Society on Thrombosis and Haemostasis (ISTH) (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2021 - 2024 Journal of Thrombosis and Haemostasis |
2026 - Present Blood Vessels, Thrombosis & Hemostasis |
Journal Review |
Thrombosis Research |
Haemophilia |
Proteoglycan Research |
Blood |
Haematologica |
Scientific Reports |
Biomaterials |
Journal of Thrombosis and Haemostasis |
Arteriosclerosis, Thrombosis, and Vascular Biology |
PLOS ONE |
Platelets |
Cardiovascular Research |
Journal of Allergy and Clinical Immunology |
Blood Advances |
Journal of Biological Chemistry |
Journal of Proteome Research |
Nature Metabolism |
Blood Vessels, Thrombosis & Hemostasis |
Journal of Clinical Investigation |
Journal of Clinical Laboratory Analysis |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2018 - Present Member, Institutional Animal Care and Use Committee, Medical College of Wisconsin, Milwaukee, WI |
2022 - Present Co-Chair, Hematopoiesis Faculty Search Committee, Versiti Blood Research Institute, Milwaukee, WI |
2022 - Present Chair, Communications Committee, Versiti Blood Research Institute, Milwaukee, WI |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2019 - 2021 Member, Scientific Committee on Megakaryocytes and Platelets, American Society of Hematology |
2022 Vice Chair, Scientific Committee on Megakaryocytes and Platelets, American Society of Hematology |
2023 Chair, Scientific Committee on Megakaryocytes and Platelets, American Society of Hematology |
2025 Grant Review, K22, K23, K25, and K99/R00 Career Transition and Development Awards, Center for Scientific Review (CSR), National Institutes of Health (NIH) |
2025 Grant Review, R03 and R21 Awards, Topics in Basic Cancer Biology, Center for Scientific Review (CSR), National Institutes of Health (NIH) |
2026 Grant Review, Hemostasis, Thrombosis, Blood Cells, and Transfusion study section (HTBT), Center for Scientific Review (CSR), National Institutes of Health (NIH) |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2003 Grant Review, North West Cancer Research (NWCR), United Kingdom |
2005 Grant Review, Health Research Council (HRC), New Zealand |
2005 Grant Review, Health Research Board (HRB), Ireland |
2013 Grant Review, Health Research Board (HRB), Ireland |
2016 Grant Review, Swiss National Science Foundation (SNSF), Switzerland |
2017 Grant Review, Foundation for Medical Research (FRM), France |
2017 Grant Review, National Research Agency (ANR), France |
2021 Grant Review, Blood Cancer UK, United Kingdom |
2021 - 2024 Co-Chair, Scientific and Standardization Subcommittee (SSC) on Platelet Physiology, International Society on Thrombosis and Haemostasis (ISTH) |
2026 Grant Review, Postdoctoral Researcher Fellowship, Research Foundation Flanders (FWO), European Science Foundation (ESF) |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Mpl Endocytosis in Megakaryocyte Homeostasis, Scientific Session Presentation, Gordon Research Conference on the Cell Biology of Megakaryocytes and Platelets, Barga, Italy, 2023 |
Membrane–cytoskeleton interactions in platelets and megakaryocytes, Invited Lecture, Inserm Unit 1237, Blood and Brain Institute @ Caen Normandy (BB@C), Cyceron, University of Caen, Caen, France, 2024 |
Membrane–cytoskeleton interactions in platelets and megakaryocytes, Invited Lecture, Inserm Unit 1255, French Blood Establishment, University of Strasbourg, Strasbourg, France, 2024 |
Membrane–cytoskeleton interactions in megakaryocytes and platelets, Invited State-of-the-Art Lecture, International Society on Thrombosis and Haemostasis Congress, Washington, DC, 2025 |
PACSIN2 as a regulator of integrin β1 function in platelets and megakaryocytes, Invited Lecture, Earl Davie Symposium, University of British Columbia Centre for Blood Research, Vancouver, Canada, 2025 |
Local |
Intertwined signaling and endocytic pathways in the megakaryocyte/platelet lineage, Research Seminar, Versiti Blood Research Institute, Milwaukee, WI, 2022 |
Role of PACSIN2 in megakaryocytes and platelets, Thrombosis and Hemostasis Program Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2022 |
Unraveling novel insights in platelet and megakaryocyte integrin β1 through PACSIN2, Thrombosis and Hemostasis Program Presentation, Versiti Blood Research Institute, Milwaukee, WI, 2023 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM, Novel GNE gene variants associated with severe congenital thrombocytopenia and platelet sialylation defect - follow up data after hematopoietic stem cell transplantation, International Society on Thrombosis and Haemostasis Congress, London, England, 2022 |
Biswas R, Eaton N, Schulte ML, Plomann M, Hoffmeister KM, Falet H, PACSIN2 regulates platelet integrin β1 hemostatic function, International Society on Thrombosis and Haemostasis Congress, London, England, 2022 |
Boyd EK, Steenackers A, Eaton N, Proamer F, Hoffmeister KM, Eckly A, Falet H, PACSIN2 regulates megakaryocyte and erythrocyte development, International Society on Thrombosis and Haemostasis Congress, Washington, DC, 2025 |
Boyd EK, Hoffmeister KM, Eckly A, Falet H, Impact of PACSIN2 on megakaryocyte and erythrocyte development, Gordon Research Symposium on the Cell Biology of Megakaryocytes and Platelets, Ventura, CA, 2025 |
National |
Boyd EK, Yttre E, Hoffmeister KM, Falet H, PACSIN2 orchestrates podosome formation during megakaryocyte maturation, Midwest Platelet Conference, Lexington, KY, 2024 |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2026 Faculty, Training Program T35 HL072483, Medical Student Summer Research Program (MSSRP) |
Graduate Student Education |
2016 - Present Faculty, Graduate School, Interdisciplinary Doctoral Program in Biomedical Sciences (IDP), Graduate Program in Cell and Developmental Biology (CDB) |
2018 Advanced Cell Biology Course: Endocytosis and Role in Cell Regulation |
2020 Advanced Cell Biology Course: Endocytosis |
2022 Advanced Cell Biology Course: Endocytosis |
2024 Advanced Cell Biology Course: Understanding Actin Assembly |
2026 Advanced Cell Biology Course: Understanding Actin Assembly |
Community/Lay Public |
2018 Faculty, Research Opportunity for Academic Development in Science (ROADS) |
2023 Faculty, Clinical and Translational Science Institute (CTSI) of Southeast Wisconsin 500 Stars Initiative |
EXTRAMURAL TEACHING: |
Graduate Student Education |
2016 - 2020 Versiti Blood Research Institute, Faculty, Training Program T32 HL007209, Research Training in Transfusion Medicine |
2016 - Present Versiti Blood Research Institute, Faculty |
2017 ISTH Academy, Webinar: platelet function testing, mechanisms of testing and clinical implications: mean platelet volume |
2018 - 2023 Versiti Blood Research Institute, Faculty, Career Development Program K12 HL141954, Glycans in Blood Homeostasis and Disease |
2024 - 2029 Versiti Blood Research Institute, Faculty, Training Program T32 HL170989, Training in Transfusion Medicine and Classical Hematology |
Community/Lay Public |
2001 - 2006 Brigham and Women’s Hospital, Division of Hematology, Webmaster |
2022 - 2024 Versiti Blood Research Institute, Social Media Manager |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
2025 - Present Gavin Hutchison, Medical College of Wisconsin |
Graduate Students |
PhD Students Advised |
2017 - 2021 Nathan Eaton, Medical College of Wisconsin |
2022 - 2026 Emily Boyd, Medical College of Wisconsin |
PhD Committees |
2022 - 2026 Anusha Rengarajan, Medical College of Wisconsin |
2023 - Present Hongyin Yu, Medical College of Wisconsin |
Faculty |
2023 - 2024 Mitchell Dyer, Medical College of Wisconsin |
2025 - Present Michelle Brenner, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
2023 Anastasia Finley, University School of Milwaukee |
2024 Elom Adjanor, Marquette University High School |
2025 Dhanush Sesham, New Berlin Eisenhower High School |
2025 Divya Rao, University School of Milwaukee |
2025 Simrin Patel, University School of Milwaukee |
2025 Sophie Perry, Mequon Homestead High School |
Undergraduate Students |
2023 Gabrielle Gooding, University of Wisconsin–Milwaukee |
2024 Naima Gaines, Howard University |
Postdoctoral Researchers |
2007 - 2014 Antonija Jurak Begonja, University of Rijeka |
2009 - 2014 Renata Grozovsky, Harvard Medical School |
2010 - 2015 Silvia Giannini, Harvard Medical School |
2011 - 2013 Hugh Kim, Centre for Blood Research, University of British Columbia |
2012 - 2014 Markus Bender, University Hospital Würzburg |
2015 - 2022 Melissa Lee-Sundlov, Versiti Blood Research Institute |
2017 - 2022 Leonardo Rivadeneyra, Versiti Blood Research Institute |
2018 - 2020 Waseem Anani, Versiti Medical Sciences Institute |
2019 - 2024 Ratnashree Biswas, Versiti Blood Research Institute |
2023 - 2024 Daniel Afosah, Virginia Commonwealth University |
2025 - Present Daniel Villalobos Garcia, Versiti Blood Research Institute |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Falet H, Rendu F. Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets. FEBS Lett. 1994 May 23;345(1):87-91. |
2. Lasne D, Donato J, Falet H, Rendu F. Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction. Thromb Haemost. 1995 Nov;74(5):1323-8. |
3. Si-Tahar M, Renesto P, Falet H, Rendu F, Chignard M. The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin. Biochem J. 1996 Jan 15;313 ( Pt 2)(Pt 2):401-8. PMCID: PMC1216922 |
4. Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F. Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets. FEBS Lett. 1996 Apr 01;383(3):165-9. |
5. Falet H, Pain S, Rendu F. Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. Biochem Biophys Res Commun. 1998 Nov 09;252(1):51-5. |
6. Pain S, Monstero-Lastres A, Falet H, Brohard-Bohn B, Fraiz N, Bachelot-Loza C, Cano E, Rendu F. Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation. FEBS Lett. 1999 Jun 18;453(1-2):119-23. |
7. Pain S, Falet H, Saci A, Bachelot-Loza C, Rendu F. Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. Cell Signal. 2000 Mar;12(3):165-71. |
8. Eaton N, Drew C, Wieser J, Munday AD, Falet H. Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. Haematologica. 2020 May;105(5):1414-1423. PMCID: PMC7193499 |
9. Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01;96(12):3786-92. |
10. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 06;276(27):24751-9. |
11. Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12;155(4):511-7. PMCID: PMC2198874 |
12. Falet H, Hoffmeister KM, Neujahr R, Hartwig JH. Normal Arp2/3 complex activation in platelets lacking WASp. Blood. 2002 Sep 15;100(6):2113-22. |
13. Falet H, Hoffmeister KM, Neujahr R, Italiano JE Jr, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16782-7. PMCID: PMC139221 |
14. Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA. Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants. Thromb Res. 2002 Sep 01;107(5):245-54. |
15. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10;112(1):87-97. |
16. Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15;101(12):4789-96. |
17. Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol. 2003 Apr;23(7):2395-406. PMCID: PMC150723 |
18. Barkalow KL, Falet H, Italiano JE Jr, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH. Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct;285(4):C797-805. |
19. Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM. Platelet moesin interacts with PECAM-1 (CD31). Platelets. 2003 Jun;14(4):211-7. |
20. Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec;15(12):1431-40. |
21. Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02;199(3):357-68. PMCID: PMC2211794 |
22. Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH. Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005 Oct;289(4):C819-25. |
23. Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 08;102(45):16263-8. PMCID: PMC1283463 |
24. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun;7(6):1019-28. PMCID: PMC3242443 |
25. Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19;114(21):4729-37. PMCID: PMC2780308 |
26. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30;207(9):1967-79. PMCID: PMC2931168 |
27. Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011 Aug 25;118(8):2285-95. PMCID: PMC3162356 |
28. Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP. Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011;6(7):e21615. PMCID: PMC3136926 |
29. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02;119(5):1263-73. PMCID: PMC3277358 |
30. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. PMCID: PMC3327460 |
31. Kim H, Falet H, Hoffmeister KM, Hartwig JH. Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. J Biol Chem. 2013 Nov 29;288(48):34352-63. PMCID: PMC3843050 |
32. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 04;5:4746. |
33. Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015 Feb 05;125(6):1014-24. PMCID: PMC4319232 |
34. Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan;21(1):47-54. PMCID: PMC4303234 |
35. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2015 Mar 06;6:6507. PMCID: PMC4400601 |
36. Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02;126(1):80-8. PMCID: PMC4492198 |
37. Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM. Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. PMCID: PMC5407363 |
38. Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK. Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01;113(11):1307-1317. PMCID: PMC5852540 |
39. Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, Falet H, Balduini A, Hoffmeister KM. β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. Nat Commun. 2020 Jan 17;11(1):356. PMCID: PMC6968998 |
40. Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM. Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. Haematologica. 2021 Jul 01;106(7):1968-1978. PMCID: PMC8252961 |
41. Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H. Bleeding diathesis in mice lacking JAK2 in platelets. Blood Adv. 2021 Aug 10;5(15):2969-2981. PMCID: PMC8361459 |
42. Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM. Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect. Thromb Haemost. 2022 Jul;122(7):1139-1146. PMCID: PMC10064489 |
43. Eaton N, Boyd EK, Biswas R, Lee-Sundlov MM, Dlugi TA, Ramsey HE, Zheng S, Burns RT, Sola-Visner MC, Hoffmeister KM, Falet H. Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. Front Oncol. 2022;12:959806. PMCID: PMC9468709 |
44. Golla K, Paul M, Lengyell TC, Simpson EM, Falet H, Kim H. A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion. Res Pract Thromb Haemost. 2023 May;7(4):100019. PMCID: PMC10394388 |
45. Biswas R, Boyd EK, Eaton N, Steenackers A, Schulte ML, Reusswig F, Yu H, Drew C, Kahr WHA, Shi Q, Plomann M, Hoffmeister KM, Falet H. PACSIN2 regulates platelet integrin β1 hemostatic function. J Thromb Haemost. 2023 Dec;21(12):3619-3632. PMCID: PMC10841284 |
46. Paul M, Hong F, Falet H, Kim H. Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets. J Thromb Haemost. 2024 Sep;22(9):2601-2607. |
47. Paul M, Hong F, Falet H, Kim H. Gelsolin controls the release of phosphatidylserine (PS)-positive microvesicles (MVs) from platelets. Cell Signal. 2024 Dec;124:111433. |
48. Weich N, Rivadeneyra L, Roisman A, Rajaraman R, Steenackers A, Zheng S, Glabere S, Desai UR, Gu T, Falet H, Gaertner F, Hoffmeister KM. Nascent preplatelets and B4GALT1 glycosylation contribute to 5-FU-induced bone marrow recovery. Blood Adv. 2026 Jul 28;10(14):5045-5057. PMCID: PMC13382792 |
Books, Chapters, and Reviews |
1. Bachelot C, Falet H, Rendu F. Platelet receptors and mechanisms of activation. Sang Thrombose Vaisseaux. 1995;7(1):39-44 (French) |
2. Barkalow KL, Falet H, Hartwig JH. Dynamics of the platelet cytoskeleton. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics, Gresele P, Page CP, Fuster V, Vermylen J, editors. Cambridge University Press, Cambridge, MA; 2002. pp.93-103. ISBN: 978-0-521-80261-1 |
3. Hoffmeister KM, Falet H. Platelet glycoproteins as lectins in hematology. In: The Sugar Code: Fundamentals of Glycosciences, Gabius HJ, editor. Wiley-VCH, Weinheim; 2009. pp.485-493. ISBN: 978-3-527-32089-9 |
4. Grozovsky R, Hoffmeister KM, Falet H. Novel clearance mechanisms of platelets. Curr Opin Hematol. 2010 Nov;17(6):585-9. PMCID: PMC4303238 |
5. Falet H. New insights into the versatile roles of platelet FlnA. Platelets. 2013;24(1):1-5. PMCID: PMC6781629 |
6. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Molecular mechanisms regulating platelet clearance and thrombopoietin production. ISBT Science Series. 2015;10(S1):309-316 |
7. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Novel mechanisms of platelet clearance and thrombopoietin regulation. Curr Opin Hematol. 2015 Sep;22(5):445-51. PMCID: PMC5326579 |
8. Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Regulating billions of blood platelets: glycans and beyond. Blood. 2015 Oct 15;126(16):1877-84. PMCID: PMC4608239 |
9. Li R, Hoffmeister KM, Falet H. Glycans and the platelet life cycle. Platelets. 2016 Sep;27(6):505-11. PMCID: PMC5396182 |
10. Hoffmeister KM, Falet H. Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance. Thromb Res. 2016 May;141 Suppl 2(Suppl 2):S68-72. PMCID: PMC5399515 |
11. Falet H. Anatomy of the platelet cytoskeleton. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update, Gresele P, Kleiman NS, López JA, Page CP, editors. Springer, New York, NY; 2017. pp.139-156. ISBN: 978-3-319-47460-1 |
12. Giannini S, Falet H, Hoffmeister KM. Platelet glycobiology and the control of platelet function and lifespan. In: Platelets, Michelson AD, Cattaneo M, Frelinger AL, Newman PJ, editors. Academic Press, Cambridge, MA; 2019. pp.79-97. ISBN: 978-0-12-813456-6 |
13. Falet H, Rivadeneyra L, Hoffmeister KM. Clinical impact of glycans in platelet and megakaryocyte biology. Blood. 2022 Jun 02;139(22):3255-3263. PMCID: PMC9164739 |
14. Rivadeneyra L, Falet H, Hoffmeister KM. Circulating platelet count and glycans. Curr Opin Hematol. 2021 Nov 01;28(6):431-437. PMCID: PMC8641398 |
15. Lee-Sundlov MM, Rivadeneyra L, Falet H, Hoffmeister KM. Sialic acid and platelet count regulation: Implications in immune thrombocytopenia. Res Pract Thromb Haemost. 2022 Mar;6(3):e12691. PMCID: PMC8994053 |
16. De Silva E, Hong F, Falet H, Kim H. Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton. Front Mol Biosci. 2022;9:1060361. PMCID: PMC9808056 |
17. Falet H. The platelet cytoskeleton. In: Platelet Physiology I: Volume 1, Platelets in Thrombotic and Non-Thrombotic Disorders, Gresele P, Kleiman NS, López JA, Page CP, editors. Springer, New York, NY; 2025. pp. 359-376. ISBN: 978-3-031-96340-7 |
Editorials, Letters To Editor, Other |
1. Falet H. Platelet size: finding the right balance. Blood. 2012 Mar 22;119(12):2702-3. |
2. Falet H. Sitosterolemia: platelets on high-sterol diet. Blood. 2013 Oct 10;122(15):2534-5. PMCID: PMC3795455 |
3. Bender M, Falet H. Post-translational arginylation as a novel regulator of platelet function. Haematologica. 2014 Mar;99(3):402-4. PMCID: PMC3943301 |
4. Grozovsky R, Falet H, Hoffmeister KM. Desialylated platelets: a missing link in hepatic thrombopoietin regulation. The Hematologist. 2015;12(3):6-7 |
5. Falet H. Singling out FLI1 in Paris-Trousseau syndrome. Blood. 2017 Jun 29;129(26):3399-3401. PMCID: PMC5492094 |
6. Boyd EK, Falet H. MAGT1 mutant platelets unveiled. J Thromb Haemost. 2023 Nov;21(11):3075-3077. |
7. Falet H, Hoffmeister KM. Elevating TPO production up a Notch. Blood. 2024 Jun 27;143(26):2684-2686. PMCID: PMC11251204 |
