CURRICULUM VITAE
Hui-Zi Chen MD, PhD
Hui-Zi Chen MD, PhD
Assistant Professor
Department of Medicine
Division of Hematology and Oncology - Medicine
Department of Medicine
Division of Hematology and Oncology - Medicine
OFFICE ADDRESS: |
Health Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
2001 - 2005 BA in Molecular and Cell Biology, Cornell University, Ithaca, NY |
2005 - 2013 MD (Medical Scientist Training Program), College of Medicine and Public Health, The Ohio State University, Columbus, OH |
2005 - 2011 PhD (Medical Scientist Training Program), The Ohio State University, Dept of Molecular Virology, Immunology, and Medical Genetics, Columbus, OH |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2013 - 2015 Residency, Internal Medicine,ABIM Research Track (Physician Scientist Training Program), The Ohio State University, Columbus, OH |
2015 - 2019 Fellowship, Medical Oncology, ABIM Research Track (Physician Scientist Training Program), The Ohio State University,, Columbus, OH |
2016 - 2019 Post-Doctoral Fellowship, The Ohio State University Comprehensive Cancer Center, Mentor: Sameek Roychowdhury, MD, PhD, Columbus, OH |
09/2019 - 01/2021 Tenure-track Assistant Professor of Internal Medicine, Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH |
02/2021 - Present Tenure-track Assistant Professor, Medicine, Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
Internal Medicine | 2016 | 2026 |
Medical Oncology | 2019 | 2029 |
AWARDS AND HONORS: |
2001 - Present National Merit Achievement Scholar |
2001 - 2005 Pauline & Irving Tanner Dean’s Scholar for Academic Excellence , Cornell |
2003 - 2004 Summer Undergraduate Research Fellow, American Heart Association |
2010 - 2011 Pelotonia Graduate Research Fellowship |
2017 - 2019 Pelotonia Postdoctoral Research Fellowship |
2018 ASCO Conquer Cancer Foundation Young Investigator Award |
2018 Excellence in Hematology and Medical Oncology Research Award, OSU |
2020 OSUCCC The James Cancer Hospital Compassionate Care Award, The James Development and Recognition Council |
2020 OSUCCC Annual Scientific Meeting Invited Junior Faculty Presentation |
2020 OSUCCC Annual Scientific Meeting Michael Hess Poster Award (Category: Translational Therapeutics) |
2021 American Society of Clinical Investigators Young Physician Scientist Award nominee (nominated by Department Chair) |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2011 - 2013 American Physician Scientist Association (APSA) |
2013 - 2015 American College of Physicians |
2015 - Present American Society of Clinical Oncology |
2015 - Present American Association of Cancer Research |
2021 - Present Society for Immunotherapy of Cancer |
2021 - Present International Association for the Study of Lung Cancer |
2022 - Present MCW Cancer Center Seminar Ambassador Group member |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
“Updates in the management of SCLC”, OncLive® State of the Science SummitTM on Lung Cancer, Columbus, OH, 03/2020 |
Regional |
Precision Medicine in Design of Cancer Clinical Trials, BSGP 8800.04 Cancer Biology & Therapeutics, 03/2020 |
Precision Medicine, 11th Annual Advances in Hematology and Oncology Fall Symposium, Green Bay, WI, 10/2022 |
Precision Medicine, 2023 WAHO Annual Conference, Green Bay, WI, 09/2023 |
Local |
Management of Hepatocellular Carcinoma, Hematology & Oncology Fellowship lecture, Milwaukee, WI, 01/2020 |
Communications Workgroup, MCW Cancer Center Precision Oncology Initiative, Milwaukee, WI, 2021 - Present |
MCW Medical Scientist Training Program Workgroup (selected by Chair of Department of Medicine), Milwaukee, WI, 2021 - Present |
Transcriptomic Analysis of Small Cell Lung Cancer, MCW Cancer Center and Genomic Sciences and Precision Medicine Center Joint Seminar, Milwaukee, WI, 04/2022 |
Advancing Therapies for Small Cell Lung Cancer, MCW Department of Medicine Grand Rounds, Milwaukee, WI, 04/2022 |
Current and Future Challenges in Treatment of Lung Cancer, MCW Department of Medicine Intern Lung Cancer Lecture, Milwaukee, WI, 05/2022 |
Treatment Updates for Small Cell Lung Cancer, 2022 Updates in Lung Cancer Symposium, Milwaukee, WI, 08/2022 |
Advancing Therapies for Small Cell Lung Cancer, MCW Cancer Center Discovery and Developmental Therapeutics Seminar, Milwaukee, WI, 09/2022 |
Management of Advanced Small Cell Lung Cancer, MCW Hematology & Oncology Fellowship Lecture, Milwaukee, WI, 10/2022 |
Introduction to Precision Medicine, MCW Department of Medicine Residents Lecture, Milwaukee, WI, 08/2023 |
EXTRAMURAL TEACHING: |
Medical Student Education |
2019 - Present The James Cancer Hospital Organ Donation Council, Physician Liaison |
2020 - Present Advisory Board for Translational Oncology, Introduction to Precision Medicine |
2020 - Present Department of Radiation Oncology Translational Research Seed Grants, Reviewer |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Clinical/Research Fellows |
06/2023 UWM Fellow: Alexia Castillo, role of arginase 2 in small cell lung cancer biology, Undergraduate Research Fellowship Mentor, MCW Cancer Center & University of Wisconsin Milwaukee (UWM) |
BIBLIOGRAPHY |
Books, Chapters, and Reviews |
1. Bonneville R, Krook MA, Chen HZ, Smith A, Samorodnitsky E, Wing MR, Reeser JW, Roychowdhury S. Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing. Methods Mol Biol. 2020;2055:119-132. PMCID: PMC7010320 |
2. Krook M*, Paruchuri A*, Wing M*, Samorodnitsky E, Bonneville R, Reeser J, Dao T, Ernst G, Barker H, Patel A, Baker K, Wilberding M, Smith A, Zehr B, Freud A, Allenby A, Chen HZ, Roychowdhury S. Focused FGFR sequencing permits fusion monitoring in serial cfDNA and reveals an expanded landscape of FGFR resistance mutations through rapid research autopsy. npj Precision Oncology, in revision. |
3. Krook MA*, Bonneville R*, Chen HZ, Reeser JW, Wing MR, Smith AM, Dao T, Samorodnitsky E, Miya J, Yu L, Freud AG, Allenby P, Roychowdhury S. Landscape of metastatic cholangiocarcinoma through rapid research autopsy. |
Abstracts |
1. Rovin BH, Zhang X, Chen HZ, Song H, Chen X. A novel regulator of chemokine expression: linking oxidative stress to inflammation. American Society of Nephrology 37th Annual Meeting and Scientific Exposition, St. Louis, MO, 2004. |
2. Chen HZ, Levitt P, Levy J, Xu X, Han L, Fan M, Weiss RW. Mutational analysis of the mouse Hus1 cell cycle checkpoint protein. Cornell University 20th Annual Undergraduate Research Forum, Ithaca, NY, 2005. |
3. Chen HZ, Wang H, Wu L, de Bruin A, House M, Ng S, Johnson J, Goldenberg LE, Fang X, Fernandez SA, Stephens JA, Naidu S, Stromberg P, Rosol TJ, Shapiro CL, Leone G. Suppression of anti-tumor immunity by E2F3. Days of Molecular Medicine Conference (Human genetics, stem cells and physiology: the future of individualized medicine), Harvard Medical School, Boston, MA, 2009. |
4. Speaker. Title of presentation: Mammalian Atypical E2Fs link Endocycle with Cancer. Great Lakes Mammalian Development Meeting, Toronto, Canada, 2011 |
5. Chen HZ, Krook M, Bonneville R, Kautto E, Miya J, Wing M, Reeser J, Freud A, Allenby P, Yu L, Roychowdhury S. Characterization of tumor heterogeneity through utilization of rapid research autopsy. OSUMC Annual Trainee Research Day, Columbus, OH, 2017. |
6. Chen HZ, Krook M, Bonneville R, Kautto E, Miya J, Wing M, Reeser J, Freud A, Allenby P, Yu L, Roychowdhury S. Characterization of tumor heterogeneity through utilization of rapid research autopsy. OSUCCC Annual Scientific Meeting, Columbus, OH, 2017. |
7. Chen HZ, Bonneville R, Samorodnitsky E, Krook MA, Miya J, Wing MR, Reeser J, Smith A, Dao T, Martin D, Guo A, Allenby P, Freud AG, Roychowdhury S. Research autopsy program for studying tumor heterogeneity and treatment resistance in advanced solid tumors. OSUCCC Annual Scientific Meeting, Columbus, OH, 2018. |
8. Speaker. Title of presentation: Research Autopsy Reveals Clonal Evolution of Metastatic Small Cell Lung Cancer. Pelotonia Fellowship Symposium, Columbus, OH, 2018. |
9. Ramsey ML, Tomlinson J, Pearlman R, Abushahin L, Aeilts A, Chen HZ, Chen Y, Compton A, Elkhatib R, Geiger L, Hays J, Jeter J, Jin N, Malalur P, Roychowdhury S, Ruple J, Prebish J, Stanich P, Hampel H. Mainstreaming germline genetic testing for patients with pancreatic cancer increases access. Familial Cancer, in press. |
10. Chen HZ, Bonneville R, Krook M, Reeser J, Wing M, Paruchuri A, Samorodnitsky E, Miya J, Smith A, Dao T, Martin D, Yu L, Freud A, Allenby P, Carbone D, Shields P, Otterson G, Roychowdhury S. Genomic characterization of recurrent small cell lung cancer through rapid research autopsy. AACR Annual Meeting, Atlanta, GA, 2019.
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11. Chen HZ, Bonneville R, Krook M, Reeser J, Wing M, Paruchuri A, Samorodnitsky E, Miya J, Smith A, Dao T, Martin D, Yu L, Freud A, Allenby P, Carbone D, Shields P, Otterson G, Roychowdhury S. Genomic characterization of recurrent small cell lung cancer through rapid research autopsy. OSUCCC Annual Scientific Meeting, Columbus, OH, 2019 |
12. Noonan AM, Lustberg MB, Schnell P, Sparreboom A, Hays J, Jin N, Abushahin L, Malalur P, Roychowdhury S, Elkhatib R, Chen HZ, Al Mutar S, Hu S. A Phase Ib Adaptive Study Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients with Metastatic Colorectal Cancer Receiving FOLOFX Chemotherapy and Bevacizumab. ASCO Annual Meeting 2020 |
13. Miller ED, Diaz DA, Arnett AL, Huang E, Gasior A, Malalur P, Chen HZ, Williams TM, Bazan JG. Identifying patterns of care for elderly patients with localized anal cancer. ASTRO 2020 |
14. TAK280 abstract |
15. HER2 in solid tumors abstract (A. Shreenivas) |
Peer Reviewed Educational Products |
1. Zhang X, Chen HZ, Rovin BH. Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. Biotechniques. 2003 Dec;35(6):1144-6, 1148. |
2. Shreenivas A, Janku F, Gouda MA, Chen HZ, George B, Kato S, Kurzrock R. ALK fusions in the pan-cancer setting: another tumor-agnostic target? NPJ Precis Oncol. 2023 Sep 29;7(1):101. PMCID: PMC10542332 |
3. Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008 Jan;14(1):62-75. PMCID: PMC2253677 |
4. Zhang X, Chen X, Song H, Chen HZ, Rovin BH. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol. 2005 Nov;35(11):3258-67. |
5. Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W. Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood. 2008 Aug 15;112(4):1013-21. PMCID: PMC2515137 |
6. Chen HZ, Bonneville R, Paruchuri A, Reeser JW, Wing MR, Samorodnitsky E, Krook MA, Smith AM, Dao T, Miya J, Wang W, Yu L, Freud AG, Allenby P, Cole S, Otterson G, Shields P, Carbone DP, Roychowdhury S. Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy. JTO Clin Res Rep. 2021 Apr;2(4):100164. PMCID: PMC8474405 |
7. Miller ED, Nalin AP, Diaz Pardo DA, Arnett AL, Huang E, Gasior AC, Malalur P, Chen HZ, Williams TM, Bazan JG. Disparate Use of Chemoradiation in Elderly Patients With Localized Anal Cancer. J Natl Compr Canc Netw. 2021 Jun 10;20(6):644-652.e2. |
8. Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009 Nov;9(11):785-97. PMCID: PMC3616489 |
9. Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A. E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010 Jan;30(2):524-36. PMCID: PMC2798461 |
10. Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009 Dec 17;462(7275):930-4. PMCID: PMC2806193 |
11. Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G. Allele-specific tumor spectrum in pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7. PMCID: PMC2841921 |
12. Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G. Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 01;351(1):35-45. PMCID: PMC3868453 |
13. Ouseph MM, Li J, Chen HZ, Pécot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G. Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62. PMCID: PMC3483796 |
14. Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G. Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202. PMCID: PMC3616487 |
15. Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G. E2f8 mediates tumor suppression in postnatal liver development. J Clin Invest. 2016 Aug 01;126(8):2955-69. PMCID: PMC4966321 |
16. Bonneville R, Krook MA, Kautto EA, Miya J, Wing MR, Chen HZ, Reeser JW, Yu L, Roychowdhury S. Landscape of Microsatellite Instability Across 39 Cancer Types. JCO Precis Oncol. 2017;2017. PMCID: PMC5972025 |
17. Chen HZ, Bertino EM, He K. Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma. J Thorac Dis. 2017 Aug;9(8):2283-2285. PMCID: PMC5594112 |
18. Chen HZ, Bonneville R, Roychowdhury S. Implementing precision cancer medicine in the genomic era. Semin Cancer Biol. 2019 Apr;55:16-27. |
19. Carr DR, Pootrakul L, Chen HZ, Chung CG. Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor. JAMA Dermatol. 2019 Jan 01;155(1):122-123. |
20. Krook MA, Chen HZ, Bonneville R, Allenby P, Roychowdhury S. Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity. Trends Cancer. 2019 Jan;5(1):1-5. |
21. Chen HZ, Bonneville R, Yu L, Wing MR, Reeser JW, Krook MA, Miya J, Samorodnitsky E, Smith A, Martin D, Dao T, Guo Q, Liebner D, Freud AG, Allenby P, Roychowdhury S. Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy. Oncotarget. 2019 Jan 08;10(3):277-288. PMCID: PMC6349455 |
22. Krook MA, Barker H, Chen HZ, Reeser JW, Wing MR, Martin D, Smith AM, Dao T, Bonneville R, Samorodnitsky E, Miya J, Freud AG, Monk JP, Clinton SK, Roychowdhury S. Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer. Prostate Cancer Prostatic Dis. 2019 Dec;22(4):624-632. PMCID: PMC6824932 |
23. Krook MA, Bonneville R, Chen HZ, Reeser JW, Wing MR, Martin DM, Smith AM, Dao T, Samorodnitsky E, Paruchuri A, Miya J, Baker KR, Yu L, Timmers C, Dittmar K, Freud AG, Allenby P, Roychowdhury S. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug;5(4). PMCID: PMC6672025 |
24. Krook MA, Lenyo A, Wilberding M, Barker H, Dantuono M, Bailey KM, Chen HZ, Reeser JW, Wing MR, Miya J, Samorodnitsky E, Smith AM, Dao T, Martin DM, Ciombor KK, Hays J, Freud AG, Roychowdhury S. Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma. Mol Cancer Ther. 2020 Mar;19(3):847-857. PMCID: PMC7359896 |
25. Paruchuri A, Chen HZ, Bonneville R, Reeser JW, Wing MR, Krook MA, Samorodnitsky E, Miya J, Dao T, Smith A, Freud AG, Allenby P, Roychowdhury S. Research Autopsy Demonstrates Polyclonal Acquired Resistance in a Patient With Metastatic GI Stromal Tumor. JCO Precis Oncol. 2020;4. PMCID: PMC7446505 |
26. Bonneville R, Paruchuri A, Wing MR, Krook MA, Reeser JW, Chen HZ, Dao T, Samorodnitsky E, Smith AM, Yu L, Nowacki N, Chen W, Roychowdhury S. Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing. Mol Cancer Res. 2021 Mar;19(3):465-474. PMCID: PMC7939074 |
27. Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S. Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. Br J Cancer. 2021 Mar;124(5):880-892. PMCID: PMC7921129 |
28. Kamgar M, Maahum M, Thapa B, Szabo A, Ahmed G, Shreenivas A, Thomas J, Deepika S, Evans D, Tsai S, Christians K, Erickson B, Hall W, Chen HZ, Lytle N, McFall T, De Sarkar N, Patrick S, George B, Kurzrock R. ATM or CHEK2 alterations as potential biomarkers of improved outcomes with irinotecan : real-world analysis of advanced pancreatic ductal adenocarcinoma. European Journal of Cancer 2023. |
29. Karan D, Dubey S, Gunewardena S, Iczkowski KA, Singh M, Liu P, Poletti A, Choo YM, Chen HZ, Leone G, Hamann MT. Manzamine A mitigates androgen receptor transcription and synthesis via pertubation of E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice. Molecular Oncology 2023? |
30. Chen HZ*, Kim NH*, Nishizaki D, Nesline MK, Conroy JM, DePietro P, Pabla S, Kato S, Kurzrock R. PD-1 transcriptomic landscape across cancers : implication for immune checkpoint blockade outcome. npj Genomic Medicine, submitted. |
31. Thapa B, Shreenivas A, Bylow K, Chen HZ, George B, Kurzrock R. Successful targeting of somatic VHL alterations with belzutifan. JCO Precision Oncology, submitted. |
32. Thompson J, Griffiths C, Menon S, Chen HZ. Invited review. New paradigms in systemic therapies for advanced lung cancer. Neoplasia. |
33. Karan D, Dubey S, Gunewardena S, Iczkowski KA, Singh M, Liu P, Poletti A, Choo YM, Chen HZ, Hamann MT. Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice. Mol Oncol. 2024 Aug;18(8):1966-1979. PMCID: PMC11306517 |
34. Thapa B, Shreenivas A, Bylow K, Chen HZ, George B, Kurzrock R. Successful Targeting of Somatic <i>VHL</i> Alterations With Belzutifan in Two Cases. J Immunother Precis Oncol. 2024 Nov;7(4):308-313. PMCID: PMC11541926 |
