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CURRICULUM VITAE

Ivor J. Benjamin MD
Center Director, Professor
Department of Medicine
Division of Cardiology

OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
1974 - 1978 B.A., Hunter College, New York, NY
1978 - 1982 M.D., Johns Hopkins University (Medicine), Baltimore, MD

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1979 Research Fellow, Johns Hopkins University, Baltimore, MD
1982 - 1983 Intern, Internal Medicine, Yale University School of Medicine, New Haven, CT
1983 - 1985 Resident, Internal Medicine, Yale University School of Medicine, New Haven, CT
1985 - 1988 Fellow, Cardiovascular Diseases, Michael Reese Hospital- University of Chicago, Chicago, IL
1989 - 1990 Research Fellow, Molecular Cardiology, Duke University Medical Center, Durham, NC
1990 - 1992 Research Fellow, Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX

FACULTY APPOINTMENTS:
1988 - 1989 Research Associate, Cardiology, Duke University Medical Center, Durham, NC
1989 - 1990 Associate in Medicine, Cardiology, Duke University Medical Center, Durham, NC
1990 - 2003 Attending Physician and Staff Cardiologist, Parkland Memorial Hospital, Dallas, TX
1990 - 2003 Attending Physician and Staff Cardiologist, Zale Lipshy Hospital, Dallas, TX
1990 - 1991 Instructor of Medicine, University of Texas Southwestern Medical Center, Dallas, TX
1991 - 1997 Assistant Professor of Medicine, University of Texas Southwestern Medical Center, Dallas, TX
1997 - 2002 Associate Professor of Medicine with Tenure, University of Texas Southwestern Medical Center, Dallas, TX
1997 - 2003 Integrative Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX
2002 - 2003 Professor of Medicine (with Tenure), University of Texas Southwestern Medical Center, Dallas, TX
2003 - 2013 Christi T. Smith Endowed Chair, Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT
2003 - 2009 Division Chief, Cardiology, University of Utah School of Medicine, Salt Lake City, UT
2007 - 2013 Attending Cardiologist, George E. Wahlen Department of Veteran Affairs Medical Center, Salt Lake City, UT
2008 - 2013 Professor of Biochemistry, Biochemistry, University of Utah School of Medicine, Salt Lake City, UT
2008 - 2017 Adjunct Professor of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT
2009 - 2013 Professor of Physiology, Physiology, University of Utah School of Medicine, Salt Lake City, UT
2009 - 2010 Visiting Scholar, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Stem Cell Institute, Boston, MA
2010 Visiting Professor, Pediatrics, Gladstone Cardiovascular Research Institute, University of California, San Francisco, CA
2013 - Present Member/Qualified Primary Dissertation Mentor, Cell and Development Biology Program, Medical College of Wisconsin, Milwaukee, WI
2013 - 2015 Chief, Medicine, Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI
2013 - 2015 Vice Chair, Medicine, Translational Research, Medical College of Wisconsin, Milwaukee, WI
2013 - Present Professor, Medicine, Physiology, Pharmacology & Toxicology, Cell Biology, & Surgery, Medical College of Wisconsin, Milwaukee, WI
2013 - Present Cardiovascular Center Director, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI
2019 - Present MCW Graduate School of Biomedical Sciences Faculty, Qualified Primary Dissertation Mentor, Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

ADMINISTRATIVE APPOINTMENTS:
2008 Leadership Development for Physician Executives, David Eccles School of Business, Salt Lake City, UT
2013 - Present Research Council, Medical College of Wisconsin, Milwaukee, WI
2013 Search Committee Member for Senior Associate Dean for Research, Medical College of Wisconsin, Milwaukee, WI
2013 - Present Executive Council of the Faculty, Medical College of Wisconsin, Milwaukee, WI
2013 Committee Member, Institutional Financial Advisory Committee, Medical College of Wisconsin, Milwaukee, WI
2015 - 2016 Scholarly Pathways Mentor, Medical School, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226
2015 - 06/30/2016 Graduate Studies Council Program Evaluation Committee Member, Graduate School of Biomedical Studies, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226
07/01/2016 - 2017 Panel Member, AHW REP Responsive LOI review panel, Medical College of Wisconsin
2019 - Present Committee Member, AHW Research & Education Advisory Committee, Medical College of Wisconsin, 8701 Watertown Plank Road, WI 53226

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
07/01/2003 - 03/01/2013 Professor with Tenure, Internal Medicine, Cardiology, University of Utah School of Medicine
02/01/2008 - 03/01/2013 Adjunct Professor, Biochemistry, University of Utah School of Medicine
11/01/2008 - 03/01/2013 Adjunct Professor, Physiology, University of Utah School of Medicine

HOSPITAL STAFF PRIVILEGES:
2013 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Ave., Milwaukee, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
Internal Medicine Board Certification
09/11/1985
None
Cardiovascular Disease Board Certification
11/08/1989
None
 
Certificates
Issued By Issue DateExpiration
Controlled Substances
State of Utah
2003
2014
 

Licensure
Number Issue DateExpiration
Texas Medical License
H9296
06/11/1991
11/30/2016
Utah Medical License
5409926-8905
11/03/2003
01/31/2014
Wisconsin Medical License
61070-20
07/12/2013
10/31/2019
 

AWARDS AND HONORS:
1975 - 1978 Thomas Hunter Honors Program, cum laude, Hunter College
1985 - 1991 Robert Wood Johnson Minority Faculty Development Award, Amos Medical Faculty Development Program
1993 Early Career Development Award, American Federation for Medical Research
1997 - 2000 Established Investigator Award, American Heart Association
1998 Award of Merit, Dallas Division AHA Affiliate
2003 - Present Christi T. Smith Endowed Chair of Cardiovascular Medicine, University of Utah School of Medicine
2009 NIH Director's Pioneer Award, National Institutes of Health
2011 Dr. Daniel D. Savage Memorial Service Award, Association of Black Cardiologists, Washington, D.C.
2019 - Present 2019 inductee into The Indispensable Role of Blacks at Johns Hopkins

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Heart Association (Chairman - Research Committee)
American College of Cardiology
American Society for Clinical Investigation
Association of University Cardiologists
Association of American Physicians

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
2004 - 2007 PloS Medicine
2005 - 2007 Cecil Essentials of Medicine (7th Edition, Invited Editor, Author, & Co-Author); Section Editor: Section I: Medicine and Molecular Biology; Section III; Cardiovascular Disease
2007 - 2009 Cecil Essentials of Medicine (8th Edition, Invited Editor, Author, & Co-Author)
2009 - Present Cecil Essentials of Medicine (9th Edition, Editor-in-Chief)
2010 - Present Journal of American Heart Association (JAHA) Consulting Editor
2011 - Present American Journal of Physiology, Heart and Circulation, Consulting Editor
01/01/2018 - Present Consulting Editor, SpringerNature
Editorial Board
1995 - Present Circulation
1997 - Present Circulation Research
2001 - 2008 Journal of Molecular Cell Cardiology
2004 - 2010 Journal of Clinical Investigation
2007 - Present Clinical and Translational Science
2011 - Present Journal of the American Heart Association (Founding Member)
2019 - 2020 Senior Advisory Editorial Board, Circulation Research
Journal Review
Molecular and Cellular Biology
Journal of Clinical Investigation
Hepatology
Circulation
Oncogene
Science
Circulation Research
FASEB Journal
American Journal of Physiology, Heart and Circulation
Cancer Chemotherapy and Therapeutics
Hypertension
Journal of Investigative Medicine
Molecular Biology of the Cell
Stroke Trends in Cardiovascular Medicine
New England Journal of Medicine
PNAS

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1985 - 1988 Committee Member, Target Activity Group (TAG), Church-Based Hypertension Control Program, Chicago Heart Association
1994 - 1999 Member-at-Large, Council on Basic Science, Executive Committee, American Heart Association
1994 Councilor, AFMR National Council, American Federation for Medical Research
1994 - 2000 Member, Stanley Sarnoff Society for Cardiovascular Research
1994 - 1999 Councilor, Councilor-at-Large, National Council, American Federation for Medical Research
1994 - 1995 Chairman, Health Education Site Committee, Dallas Affiliate, American Heart Association
1995 - 1997 Chair, Education Committee, American Federation for Medical Research
1995 - 1996 Member, Council on Circulation, Melvin L. Marcus Young Investigators Awards in Cardiovascular Physiology Selection Committee, American Heart Association
1996 - 1998 Chair, National Council, Education Committee, American Federation for Medical Research
1997 - 1999 Member, Selection Committee, Louis N. and Arnold M. Katz Basic Science Prizes for Young Investigators, Council on Basic Science, American Heart Association
1997 - 1998 Chair, Scientific Board, Endowment Committee, Stanley Sarnoff Society for Cardiovascular Research
1998 - 1999 Task Force Member, Council Resources, American Heart Association
2001 - 2005 Member, Scientific Publishing Committee, American Heart Association
2001 - 2002 President, Dallas Division of Texas Affiliate, American Heart Association
2001 Fellow, American Heart Association
07/01/2002 - 06/30/2003 Immediate Past President, Southwest Affiliate Board, American Heart Association
2003 - 2004 Member, Council on Basic Cardiovascular Sciences Annual Conference Planning Committee, American Heart Association
2003 - 2005 Chair, Scientific Publishing Committee, American Heart Association
2003 - 2017 Member, Science Advisory and Coordinating Committee, American Heart Association
2003 - 2004 Vice Chair, Council for Basic Cardiovascular Sciences, American Heart Association
2004 - 2005 Board Member, Board of Scientific Counselors, National Heart, Lung, and Blood Institute
2004 Organizer, 1st Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences: Stress Signals, Molecular Targets and the Genome, American Heart Association
2005 - 2007 External Advisor, External Advisory Committee, University of Hawaii Research Scientist Award in Molecular Cardiology, National Heart, Lung, and Blood Institute
2005 - Present Officer & Council Member, North American Chapter, International Academy of Cardiovascular Sciences
2005 Co-Chair, Gordon Research Pre-Conference, A World Without Heat Shock Factors, Gordon Research Conferences
2006 - 2007 Committee Member, Manuscript Oversight Committee, American Heart Association
2007 - 2015 Member, Board of Directors, Stanley Sarnoff Society for Cardiovascular Research
2007 - 2009 Chair, International Committee, American Heart Association
2009 - 2016 Council Member, Association of University Cardiologists
2010 Chair, Elsevier Retreat Meeting, Elsevier
2010 Co-Chair, Keystone Symposium on Mechanisms of Cardiac Growth, Death, and Regeneration, Keystone Symposia
05/2015 - 05/2017 Chair, Research Committee, American Heart Association
07/01/2015 - 06/30/2016 Ex-officio, Midwest Affiliate Board, American Heart Association
11/23/2015 - Present Committee Member, Institute for Precision Cardiovascular Medicine Executive Committee, American Heart Association
01/2016 - 01/2017 President, Association of University Cardiologists
07/01/2016 - Present Board Member, Midwest Affiliate Board of Directors, American Heart Association
07/01/2016 - 06/30/2018 Member, National Research Funding Subcommittee, American Heart Association
07/01/2016 - 06/30/2018 Midwest Affiliate Health and Research Strategies Committee, American Heart Association
07/01/2016 - 06/30/2018 Midwest Affiliate Board, American Heart Association
07/01/2017 - 07/01/2018 AHA/ASA President-Elect, National Board of Directors, American Heart Association
07/01/2017 - 07/01/2018 Ex-Officio Member, Advocacy Coordinating Committee, American Heart Association
07/01/2017 - 06/30/2018 President-Elect, National Advocacy Coordinating Committee, American Heart Association
07/01/2017 - 06/30/2018 Member, National Institute for Precision Cardiovascular Medicine Executive Committee, American Heart Association
07/01/2017 - 07/01/2018 Vice Chairperson, Science Advisory Coordinating Committee, American Heart Association
07/01/2017 - 07/01/2018 Member, Corporate Operations Coordinating Committee, American Heart Association
07/01/2017 - 07/01/2018 Member, International Committee, American Heart Association
07/01/2017 - 06/30/2018 Vice-Chairperson, National Science Advisory and Coordinating Committee, American Heart Association
07/01/2017 - 06/30/2018 President-Elect, National Executive Committee, American Heart Association
07/01/2017 - 06/30/2018 Chairperson, National Research Committee, American Heart Association
07/01/2017 - 06/30/2018 President-Elect, National Board of Directors, American Heart Association
07/01/2017 - 06/30/2018 President-Elect, National Corporate Operations Coordinating Committee, American Heart Association
07/01/2017 - 06/30/2019 Ex-Officio, Non-Voting, National International Committee, American Heart Association
12/15/2017 - 06/30/2018 President-Elect, National Governance Committee, American Heart Association
07/01/2018 - 06/30/2019 President, National Corporate Operations Coordinating Committee, American Heart Association
07/01/2018 - 06/30/2019 Member, National Institute for Precision Cardiovascular Medicine Executive Committee, American Heart Association
07/01/2018 - 06/30/2019 President, National Past Officers, American Heart Association
07/01/2018 - 06/30/2019 President, National Research Funding Subcommittee, American Heart Association
07/01/2018 - 06/30/2019 Member, National Budget Review Subcommittee, American Heart Association
07/01/2018 - 06/30/2019 President, National Executive Committee, American Heart Association
07/01/2018 - 07/01/2019 President, National Board of Directors, American Heart Association
07/01/2018 - 06/30/2020 Midwest Affiliate Board Member, American Heart Association
07/01/2018 - 06/30/2019 President, National Governance Committee, American Heart Association
07/01/2018 - 06/30/2019 Chairperson, National Science Advisory and Coordinating Committee, American Heart Association
07/01/2018 - 06/30/2020 Speaker, National Media Spokesperson, American Heart Association
07/01/2018 - 06/30/2019 President, National Advocacy Coordinating Committee, American Heart Association
07/01/2018 - 06/30/2019 President, National Compensation, Benefits and HR Committee, American Heart Association
09/2018 - 2019 Chair, PRIDE Renewal Review Panel, NHLBI
2018 - 2019 Chairman, AHA Merit Peer Review, American Heart Association
05/2019 - Present Member, Technology & Transformation Sub-Committee, National Quality Forum Task Force

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Cardiovascular Roadmap: Bridging our Foundations to Signature Programs
Source:
Advancing a Healthier Wisconsin (AHW)
Role:
Primary Investigator
PI:
Ivor J. Benjamin, MD
Dates:
06/2014 - 06/2019
Direct Funds:
$4,000,000 (The major objectives of the AHW Award are as follows: i) Expand the infrastructure with personnel to support translational research, ii) recruit translational investigators, iii) support training especially for clinical and basic junior investigators, and 4) modest seed grant program. There is neither scientific nor budgetary overlap with the proposed work.)
 
Title:
Suppression of lamin-induced muscle defects
Source:
Muscular Dystrophy Association
Role:
Co-PI (Benjamin)
PI:
Wallrath (PI, University of Iowa)
Dates:
02/2017 - 01/2020
 
Title:
Training in Signature Transdisciplinary Cardiovascular Sciences
Source:
National Institutes of Health (NIH)
Role:
PI
PI:
Ivor Benjamin, MD
Dates:
05/01/2017 - 04/30/2022
Direct Funds:
$1,491,852 (The major objectives of this institutional NRSA application for postdoctoral training (2 new slots/year) are to train the next generation of cardiovascular scientists, including underrepresented minorities, by incorporating a broad-based, personalized, supportive, and rigorous training opportunities at the Medical College of Wisconsin Cardiovascular Center. There is neither scientific nor budgetary overlap with the proposed work.)
 
Title:
Phase 1 Study of Autologous iPSC-based vaccines in Patients with Non-small Cell Lung Cancer
Source:
MCW Cancer Center
Role:
PI
PI:
Ivor Benjamin
Dates:
2018 - Present
 
Pending
Peer Review
Title:
Modeling Personalized and Predictive Determinants of Cancer Therapeutics o Prevent Cardiotoxicity
Source:
CVC-AHW Endowment
Role:
PI
PI:
Ivor Benjamin
Dates:
2018 - Present
 
Title:
Modeling individualized cardio-oncology risk stratification and prevention of cancer treatment-related cardiotoxicity
Source:
NIH NHLBI
Role:
PI
PI:
Ivor Benjamin
Dates:
2019 - Present
 
Prior
Peer Review
Title:
Minority Medical Faculty Development Award
Source:
Robert Wood Johnson Foundation
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
01/1985 - 01/1991
Direct Funds:
$270,000
 
Title:
Minority Investigator Research Supplement to "Exercise and Mitochondrial Biogenisis"
Source:
National Institutes of Health (NIH)
Role:
Co-Investigator
PI:
R. Sanders Williams
Dates:
01/1990 - 01/1992
 
Title:
Molecular Targets of Stress Proteins During Recovery from Ischemia - SCOR, Subproject 5B
Source:
National Institute of Health (NIH)
Role:
Project Header
PI:
R. Sanders Williams
Dates:
01/1992 - 01/1994
Direct Funds:
$180,000 ((5-P50-HL 17669-20))
 
Title:
Early Career Development Award
Source:
American Federation for Medical Research
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
01/1993 - 01/1996
Direct Funds:
$60,000
 
Title:
Expression of Stress Proteins in the Ischemic Heart
Source:
National Institute of Health (NIH)
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
01/1994 - 01/1999
Direct Funds:
$490,030 ((1-K14 HL 03155-03))
 
Title:
Training in Cardiovascular Research. Cost Reimbursable
Source:
US Public Health Service (PHS)
Role:
Principal Investigator (Transferred to Dean Li, MD, PhD, 2010)
PI:
Ivor J. Benjamin, MD
Dates:
07/1994 - 01/2010
Direct Funds:
$1,961,755 ((HL T32 507576))
 
Title:
αB-Crystallin In The Diabetic Heart
Source:
National Cancer Institute
Role:
Project Header
PI:
R. Sanders Williams
Dates:
01/1995 - 01/2000
Direct Funds:
$2,900,000
 
Title:
Regulation and Function of αB crystallin in striated muscle
Source:
American Heart Association
Role:
Primary Investigator
PI:
Ivor J. Benjamin
Dates:
01/1997 - 01/2000
Direct Funds:
$300,000
 
Title:
Mechanisms for Cardioprotection in HSFI Knockout Mice
Source:
National Institute of Health (NIH)
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
01/1998 - 01/2003
Direct Funds:
$1,036,294
 
Title:
Platform Technologies for Cardiovascular Therapies - Microarrays and Synthetic Transcription Factors - Reynolds Grant, Project 4
Source:
American Heart Association
Role:
Co-Investigator
Dates:
01/1999 - 01/2001
 
Title:
Genomewide Analysis of Placental and Growth Defects in Hsfl Knockout Mice
Source:
March of Dimes
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
01/2000 - 01/2003
Direct Funds:
$264,666
 
Title:
HSF 1 Requirements in Extraembryonic Development. Cost Reimbursable
Source:
National Institute of Child Health and Human Development
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2003 - 06/2007
Direct Funds:
$720,460
 
Title:
Alpha Beta-Crystallin R120G Cardiomyopathy.
Source:
National Heart, Lung, and Blood Institute (NHLBI)
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
08/2003 - 07/2005
Direct Funds:
$202,819
 
Title:
Oxido-reductive Stress on Molecular Properties of Chaperone Hsp25 (HSPB1) in hR120G CryAB Cardiomyopathy in Mice. (0755022Y)
Source:
American Heart Association Western States Affiliate
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2007 - 06/2009
Direct Funds:
$127,272
 
Title:
Modeling Reductive Stress and Protein Aggregation Diseases in Drosophila; SYNERGY Grant
Source:
University of Utah
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
10/2007 - 09/2008
Direct Funds:
$50,000
 
Title:
Mechanisms of HSPB2 in Cardiac Metabolism and Ischemic Cardioprotection. (R01HL074370-
Source:
National Institutes of Health
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
05/2008 - 03/2013
Direct Funds:
$1,061,256
 
Title:
Conditional HSF1 Expression for Ischemic Cardioprotection
Source:
VA Merit Review
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
10/2008 - 03/2013
 
Title:
Protein Misfolding & Oxido-Reductive Stress. (8DP1HL17650-04)
Source:
NIH National Heart, Lung and Blood Institute Pioneer Award Grant (NCE)
Role:
Primary Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2009 - 07/2015
Direct Funds:
$250,000 (The major objectives of the Director’s DP1 Award are as follows: i) to exploit the genetically tractable and versatility of Drosophila melanogaster for disease modeling of reductive stress, ii) to identify and characterize the NADPH-dependent pathways in reductive stress, and iii) to perform disease modeling of reductive stress using induced pluripotent human stem cells for rescuing reductive stress in the clinic. There is neither scientific nor budgetary overlap with the proposed work.)
 
Title:
Reductive Stress in the Pathogenesis of R120GCryAB Cardiomyopathy. (R01HL063834) No-Cost Extension through 2012
Source:
National Heart, Lung, and Blood Institute
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2009 - 06/2012
Direct Funds:
$581,044
 
Title:
Epigenetic Mechanisms of Cardiomyopathy and Oxido-reductive Pathways
Source:
American Heart Association Western States Affiliate
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2009 - 06/2011
Direct Funds:
$581,044
 
Title:
Protein Misfolding & Oxido-Reductive Stress. (8DP1HL17650-04)
Source:
NIH National Heart, Lung and Blood Institute (NHLBI)
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
09/2009 - 07/2014
Direct Funds:
$2,500,000
 
Title:
Redox & Nitrosative Modulation of Left Ventricular Remodeling. (09CVD01)
Source:
Fondation LeDucq (NCE)
Role:
Project Leader
PI:
David Kass; A.J. Shah (Co-PIs)
Dates:
01/2010 - 12/2015
Direct Funds:
$454,900 (The major objectives of the Leducq Fondation Award are as follows: i) Expand the infrastructure with personnel to support translational research, ii) recruit translational investigators, iii) support training especially for clinical and basic junior investigators, and 4) modest seed grant program. There is neither scientific nor budgetary overlap with the proposed work.)
 
Title:
Redox Control of Human iPS Cells for Cardiac Regeneration.
Source:
University of Utah Seed Grant
Role:
Principal Investigator
PI:
Ivor J. Benjamin, MD
Dates:
07/2011 - 07/2012
Direct Funds:
$28,000
 
Title:
Patient-Specific Induced Pluripotent Stem–Cell models for R120GCryAB Cardiomyopathy
Source:
American Heart Association Western States Affiliate
Role:
Supervisor
PI:
Pat Limphong
Dates:
01/2012 - 12/2012
Direct Funds:
$88,000
 
Title:
Modeling Inheritable Myofibrillar Myopathy with Patient-Specific iPS Cells
Source:
National Institute of Arthritis, Musculoskeletal and Skin Diseases of the National Institute of Health
Role:
Sponsor
PI:
Mitzelfelt, K.
Dates:
08/08/2015 - 08/07/2017
Direct Funds:
$30,912 (Goals: Generation and characterization of an iPSC model of myopathy using cells derived from a patient harboring the recessive 343delT HSPB5 mutation.)
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
"Modeling Atrial Fibrillation in the Era of Personalized Medicine.", Comprehensive Arrhythmia Research & Management Center (CARMA),, University of Utah, Salt Lake City, Utah, 2011
"Cardiovascular Medicine in the 21st Centure: Lessons From Randomized Trials to Stem Cells.", Medical Student Research Seminar, University of Utah, Salt Lake City, Utah, 2012
"Cross-Talk between Redox Signaling Networks and Metabolic Pathways.", Metabolism Interest Group Lecture, University of Utah, Salt Lake City, UT, 2012
"Cardiovascular Medicine in the 21st Century: From Clinical Trial to Stem Cells", Symposium for Senior Physicians, Medical College of WI; Milwaukee, WI, 08/2013
Opening remarks, VT Symposium, Medical College of Wisconsin, 08/02/2014
Mitochondrial-nuclear crosstalk and Oxido-Reductive Stress in Health and Disease, Grand Rounds, University of Alabama - Birmingham, 09/16/2014
Mitochondrial-nuclear Crosstalk and Oxido-Reductive Stress in Health and Disease, Grand Rounds, The University of Texas Medical Branch at Galveston, 10/16/2014
Diseases of the Pericardium, Faculty Teaching in CV Unit, Medical College of Wisconsin, 10/20/2014
CARDIOMYOPATIES : Perspectives on the Past, Present and Future, Fellows' Core Educational Conferences, Medical College of Wisconsin, 10/28/2014
Benjamin, Ivor, The Cardiovascular Center (MCW), Herma Heart Center Research External Advisory Committee Review, Medical College of Wisconsin, 07/06/2017
Benjamin, Ivor, Diseases of the Pericardium, Teaching CV Unit - M2 Students, Medical College of Wisconsin, 10/17/2017
 
Regional
"Molecular Biology of Heat Shock (Stress) Proteins and their Applications in Cardiovascular Medicine.", Cardiology Grand Rounds, Henry Ford Museum, Detroit, MI, 1995
"Cardiac Manifestations of Diabetic Heart Disease.", Internal Medicine Grand Rounds, University of Texas Southwestern Medical Center, Dallas, TX, 1995
"Heat Shock Proteins: Their Roles in Cardiovascular Disease.", Cardiology Grand Rounds, The University of Pennsylvania School of Medicine, Philadelphia, PA, 1997
"Stress (HSP) Proteins: From Cardioprotection to Pathogenesis in Genetic Forms of Cardiovascular Disease.", Cardiology Grand Rounds, The University of Louisville, Louisville, KY, 2000
"Matrix Metalloproteinases: From Biology to Therapeutic Strategies In Cardiovascular Disease.", Internal Medicine Grand Rounds, University of Texas Southwestern Medical Center, Dallas, TX, 2000
Visiting Professor for Cardiology Grand Rounds, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, 2000
"HSP and HSF Regulators: Partners in Cardioprotection.", Cardiology Grand Rounds, Heart and Lung Institutes, Ohio State University, Columbus, OH, 2001
"A Novel Mitochondrial Oxidative Stress-HSP Chaperone Pathway in Cardioprotection.", Cardiology Grand Rounds, Johns Hopkins University, Baltimore, MD, 2002
"Cardiac Hypertrophy: From Bench to Bedside.", Internal Medicine Grand Rounds, University of Utah, Salt Lake City, UT, 2003
Department of Surgery Grand Rounds, University of Utah, Salt Lake City, UT, 2004
"Protein Misfolding Disorders and Heart Disease.", Medical Grand Rounds, Duke University, Raleigh-Durham, NC, 2005
"Glutathione Redox Balance: New Insights into the Pathogenesis of Heart Failure.", Cardiology Grand Rounds Clinical Fellows Distinguished Speakers Series, Johns Hopkins University School of Medicine, Baltimore, MD, 2006
"Reductive Stress: A New Paradigm for Understanding Redox Imbalance in Heart Failure.", Cardiology Grand Rounds, University of Utah, Salt Lake City, UT, 2006
"Oxido-Reductive Stress: New Insights in the Pathogenesis of Inheritable Heart Failure.", Department of Cardiology Grand Rounds, University of Texas M.D. Anderson Cancer Center, Houston, TX, 2006
"Reductive Stress in the Pathogenesis of Cardiac Sudden Death and Failure.", Catalyst Renewal, University of Utah, Salt Lake City, UT, 2007
"Reductive Stress: A New Paradigm for Understanding Cardiac Metabolic and Protein Aggregation Diseases.", Metabolism Interest Group, University of Utah, Salt Lake City, UT, 2007
"Oxido-Reductive Stress: A Novel Discovery in Protein Aggregation Disease.", Cell Biology Seminar Series, Cleveland Clinic, Cleveland, OH, 2008
"Mechanisms for Protein Quality Control in Health and Disease.", Molecular Biology Program, Center for Cardiovascular Translational Biomedicine, University of Utah, Salt Lake City, UT, 2008
"Reductive Stress in the Pathogenesis of Cardiac Sudden Death and Failure.", Catalyst Mid-year Renewal, University of Utah, Salt Lake City, UT, 2008
"Protein Misfolding Disease and Oxido-Reductive Stress.", Cardiology Grand Rounds, University of Utah, Salt Lake City, UT, 2009
"Heart Throbs and Beats in the New Era of Stem Cells.", Women Investing in Service and Health (WISH) Meeting, University of Utah, Salt Lake City, UT, 2009
"Protein Misfolded Diseases and Oxido-Reductive Pathways.", Catalyst Renewal, University of Utah, Salt Lake City, UT, 2009
"Stem Cells and Cardiac Regeneration: Pitfalls and Promises.", Cardiology Grand Rounds, University of Utah, Salt Lake City, UT, 2009
"Redox Signaling Networks Underlying Protein Diseases in Flies and Mice.", Cardiovascular Hypertension and Diabetes Symposium, University of Utah, Salt Lake City, UT, 2010
"Oxido-Reductive Stress Signaling Networks: New Targets in Heart Disease.", Cardiovascular Institute Grand Rounds, Whitaker Cardiovascular Institute, Boston University, Boston, MA, 2010
"Oxido-Reductive Stress: A Novel Mechanism Underlying Heart Failure and Protein Aggregation Diseases.", Beth Israel Deaconess Medical Center, Cardiovascular Research Seminar Series, Boston, MA, 2010
"Genetic Mechanisms of Protein Aggregation Diseases.", Molecular Biology Program, University of Utah, Salt Lake City, UT, 2010
"Modeling Oxido-Reductive Stress Signaling Networks Linked to Protein-Induced Heart Disease in Flies and Mice.", Stanford School of Medicine, Frontiers in Cardiovascular Science Seminar Series, Palo Alto, CA, 2011
"Modeling Oxido-Reductive Stress Signaling Networks and Protein Aggregation Disease in Flies and Mice.", Cardiology Special Seminar, Hunter College, New York City, NY, 2011
"Redox Signaling Networks Underlying Protein Diseases in Flies and Mice.", Cardiovascular Hypertension and Diabetes Symposium, University of Utah, Salt Lake City, UT, 2011
"Inheritable Cardiomyopathies: New Insights from Model Systems.", Frontiers in the Heart Institute Seminar, Cedars Sinai Medical Center, Los Angeles, CA, 2012
"Atrial Fibrillation: A Personalized Perspective.", Heart Institute Grand Rounds, Cedards Sinai Medical Center, Los Angeles, CA, 2012
"Atrial Fibrillation: A Personalized Perspective in the Genomic Era.", UCSD Clinical Cardiology Grand Rounds, San Diego, CA, 2012
"Modeling Protein-Induced Heart Diseases Linked to Oxido-Reductive Stress Signaling Networks in Flies and Mice.", Grand Rounds, Case Western University, Cleveland, OH, 2012
"Models of inheritable protein misfolding cardiac diseases reveal new insights on redox metabolism.", Cardiology Grand Rounds, Vanderbilt University, New Haven, CT, 05/08/2013
"Atrial Fibrillation: A personalized approach for the 21st Century.", Medicine Grand Rounds, Vanderbilt University, New Haven, CT, 05/09/2013
“Cardiovascular Medicine in the 21st Century: Lessons from Randomized Trials to Stem Cells", Cardiovascular Medicine Grand Rounds, Yale University School of Medicine, New Haven, Connecticut, 2013
“Cardiac Recover and IPS cells.”, Utah Cardiac Recovery Symposium (U-CARS), University of Utah, Salt Lake City, Utah, 2013
“Molecular (HSP) Chaperones: Crosstalk between a Healthy Proteome and Cardiovascular Diseases.”, Microbiology and Molecular Biology Seminar, Brigham Young University, Provo, Utah, 2013
"Atrial Fibrillation: A Personalized Approach for the 21st Century.", Cardiac Grand Rounds, University of Calgary, Calgary, Canada, 2013
Mitochondrial-nuclear crosstalk and Oxido-Reductive Stress in Health and Disease., 2014 Cardiology Research Symposium, Emory University School of Medicine; Atlanta, GA, 06/2014
Cardiac Stem Cells in Health and Disease, NIU CVVS Seminar Series, Northern Illinois University, 04/17/2015
Benjamin, Ivor, Protein Misfolding Diseases: Lessons from Alzheimer’s Disease to Cardiomyopathy, Cardiovascular Research Center Seminar Series, MGH/Boston, 02/27/2018
"Atrial Fibrillation: Global Challenges and Opportunities", University of Wisconsin-Madison, Cardiovascular Medicine Grand Rounds, Madison, Wisconsin, 03/14/2019
"Protein Misfolding Diseases: Lessons from Alzheimer's to Cardiomyopathy", University of Wisconsin-Madison, Department of Medicine Grand Rounds, Madison, Wisconsin, 03/15/2019
 
National
"Induction of Stress Proteins During Ischemia.", Pharmacology Basic Research Seminar Program, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 1991
"Heat-Shock Proteins and Ischemic Injury.", Forefronts in Nephrology Symposium, International Society of Nephrology, Cade Code, MA, 1991
"Molecular Biology of Heat Shock Proteins.", Postgraduate Seminar, American Heart Association 67th Scientific Meeting, Atlanta, GA, 1993
"Exogenous and Endogenous Gene Expression of Heart Shock Proteins In the Intact Animal; Implications for Ischemic Myocardial Protection.", Research Seminar, Parke-Davis Pharmaceutical Co., Ann Arbor, MI, 1994
"Cellular and Regional Expression of the Major Hsp70 Isoforms in the Ischemic Rabbit Heart.", Featured Research Presenter. American Heart Association 67th Scientific Meeting, Dallas, TX, 1994
"Heat Shock Proteins and Cellular Protection: Mechanisms and Missions.", Department of Pharmacology's Basic Research Seminar. University of Michigan Medical School, Ann Arbor, MI, 1995
"Mechanisms for Regulation and Function of Heat Shock (Stress) Proteins in Myogenic Lineages.", National Eye Institute, National Institutes of Health, Bethesda, MD, 1995
"Transgenic Models to Reduce the Sensitivity of the Cardiac Myocyte to Ischemic Stress.", AHA Scientific Program on "Somatic Cell Therapy for Cardiovascular Diseases.", Anaheim, CA, 1995
"Mouse Models for Cardiovascular Research.", NIH Workshop sponsored by the Division of Heart and Vascular Diseases, Bethesda, MD, 1995
"Basic Molecular Biology for Clinicians.", American College of Cardiology Scientific Symposia, Orlando, FL, 1996
"Genetics of Hypertension.", International Society on Hypertension in Blacks, New Orleans, LA, 1996
"Hypertension and Ischemic Heart Disease.", Faculty Lecture, American Society of Hypertension, New York City, NY, 1996
"Regulatory Mechanisms of Eukaryotic Heat Shock Gene Expression.", Chaparonin Research Group, UT Southwestern Medical Center, Dallas, TX, 1997
"Heat-Shock" Stress Proteins as Cardioprotective Agents.", Meharry Medical College, School of Graduate Studies and Research, Nashville, TN, 1997
"Heat Shock Proteins and Myocardial Protection.", Experimental Biology Symposium, American Physiological Society, New Orleans, LA, 1997
"Regulatory Mechanisms of Mammalian Heat Shock Gene Expression.", Department of Biochemistry, Molecular Biology & Cell Biology, Northwestern University, Chicago, IL, 1997
"Stress 'Heat Shock' Proteins: Regulation and Function in Mammalian Development and Physiological Adaption.", University of Washington, Seattle, WA, 1998
"Regulation and Function of Chaperone (HSP) Networks in Mammals: Current Perspectives and Future Directions.", Texas Tech University, Lubbock, TX, 1998
Keynote Address: Sixth Annual Cardiovascular Minority Research Supplement Symposia sponsored by the National Heart, Lung, and Blood Institutes, 71st Annual Scientific Sessions of the American Heart Association, Dallas, TX, 1998
Keynote Address: "Stress Proteins: Beyond Cardioprotection in Cardiac and Vascular Biology.", International Society for Heart Research, Ann Arbor, MI, 1998
"Heat Shock 'Stress' Proteins: New Paradigms in Biology and Medicine.", 1999 Lindenbaun Visiting Professor and Lindenbaum Memorial Lecture, Columbia University College of Physicians and Surgeons, New York, NY, 1999
"Stress (Heat Shock) Proteins: Molecular Chaperones in Cardiovascular Health and Disease.", Ohio State University, Columbus, OH, 1999
"Stress Proteins and Regulatory Networks.", American Heart Association and National Institutes of Health Joint Conference on the Failing Heart, Snowbird, UT, 1999
"Stress 'Heat Shock' Responses and Regulatory Pathways in Cardiovascular Biology and Disease.", Institute of Molecular Medicine and Genetics, Medical College of GA, 1999
"HSP Transcriptional Networks in Cardiovascular Biology and Disease: An Overview.", International Society for Heart Research, 22nd Annual Meeting, Louisville, KY, 2000
"Regulatory and Cellular Stress Response (Hsp) Pathways for Cardioprotection.", University of Chicago, Chicago, IL, 2000
"Mammalian HSF Regulators: New Paradigms from Gene Knockout Models.", 3rd International Symposium of Heat Shock in Biology and Medicine Conference, Woods Hole, MA, 2000
"Genetic Influences on Myocardial Ischemia.", 73rd Annual Scientific Sessions of American Association, New Orleans, LA, 2000
"Stress (HSP) Proteins and HSF Regulatory Networks in Cardiovascular Biology and Disease.", Loyola University Medical Center, Maywood, IL, 2001
"Alternative Strategies for HSP-Mediated Protection Against Oxidative Damage in the Cardiovascular System.", University of Michigan Medical School, Ann Arbor, MI, 2001
"Stress Proteins and the HSF1 Regulatory Network in Biostress Adaption.", University of Connecticut Health Center, Farminton, CT, 2001
"Stress 'heat-shock' Proteins and Regulatory Pathways: Perspectives of a Physician-Scientist.", State University of New York, Old Westbury, NY, 2001
"Look Before you Leap and Pump.", The National Eye of Institute, Washington, D.C., 2001
"Mammalian Stress Response Pathways (HSP) in an Era of Cardiovascular Functional Genomics.", Boston University School of Medicine, Boston, MA, 2001
"Stress Response" 'Heat Shock' Pathways in Cardiovascular Diseases: Are clinical applications on the Horizon?", Duke University Medical Center, Durham, NC, 2001
"Stress (HSP) Proteins and HSF Regulatory Networks in Cardiovascular Biology and Disease.", Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 2001
"Endogenous Cytoprotective Mechanisms and HSP Regulatory Pathways.", 31st Critical Care Congress, San Diego, CA, 2002
"Alternative Pathways for Cardioprotection by HSPs in the Ischemic Heart.", Experimental Biology 2002 Annual Meeting, New Orleans, LA, 2002
"Chaperone Defenses: Crosstalk between Transcriptional Networks and Redox-Sensitive Mechanisms.", University of Cincinnati Medical Center, Cincinnati, OH, 2002
"HSP Chaperone-Mitochondrial Oxidative Stress Pathways in Cardioprotection.", Rhode Island Hospital, Brown Medical School, Providence, RI, 2002
"Molecular Chaperones (HSP): Post-translational Control of Mitochondrial ROS Production, Medical College of Wisconsin, Milwaukee, WI, 2002
"Cardiac Redox State and the HSF1 Regulatory Pathway in Mice.", AHA Snowbird Conference on Advances in the Molecular and Cellular Aspects of Heart Failure, 2002
"Functional Proteomics: Ischemia Induced Posttranslational Modifications in the Mitocondrial Proteome.", Experimental Biology 2003, San Diego, CA, 2003
"Left Ventricular Hypertrophy and Cardiac Remodeling.", AHA Minority Health Summit, Atlanta, GA, 2003
"A Novel Pathway for Cytosolic Chaperones in Mitochondrial ROS and RNS Production.", Distinguished Cardiovascular Leadership, University of California, Los Angeles, CA, 2004
"Novel roles for cystolic chaperones in Mitrochondrial ROS production: Mitochondrial nitric oxide synthase is not eNOS, nNOS, or iNOS.", AHA Council on Basic Cardiovascular Sciences, "Stress Signals, Molecular Targets, and the Genome, Co-organizer of Conference, Skamania Lodge, WA, 2004
"A novel role for cytosolic chaperones in mitochondrial RNS production.", Lectures on Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, 2004
"Reductive Stress in the Pathogenesis of Mutant CYAB Myfilrillar Cardiomyopathy.", Keynote speaker for the NHLBI Short Term Student Training Grant, UMDMJ, Newark, NJ, 2005
"Glutathione Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy.", 3rd Edward A. Khairallah Memorial Symposium, University of Connecticut, Storrs, CT, 2006
"Biosignatures for Heart Failure in the Genomic Era.", Southern Society for Clinical Investigation, International Academy of Cardiovascular Science/ N. America, Southern Reginal Meetings, New Orleans, LA, 2007
"Oxido-Reductive Stress in Heart Failure: 'Thinking Outside the Box.'", 43rd Annual Neuton Stern Visiting Professorship, The University of Tennessee Health Science Center, Memphis, TN, 2008
"Oxido-Reductive Stress & Protein Aggregation Cardiomyopathy.", AHA Conference, New Orleans, LA, 2008
"Oxido-Reductive Stress: A Novel Discovery in Protein Aggregation Cardiomyopathy.", AHA Keystone Basic Cardiovascular Sciences Conference, Keystone, CO, 2008
"Protein Aggregation Diseases and Oxido-Reductive Stress.", RMCI Talk, Hawaii, USA, 2009
"Reductive Stress: A New Player in Human Cardiomyopathies.", AHA Scientific Sessions, Orlando, FL, 2009
"Reductive Stress: Basic Mechanisms and Implications for Protein Aggregation Diseases.", Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, 2009
"The Pathogenesis and Molecular Mechanisms of Protein Aggregation Diseases.", Gordon Research Conference on Stress Proteins in Growth, Development, and Disease, Proctor Academy, Andover, NH, 2009
"The Pathogenesis and Molecular Mechanisms of Protein Aggregation Diseases.", NIH Director's Pioneer Award Presentation, Bethesda, MD, 2009
"Stress Reductive or Reductive Stress: Ancient Chaperones in the Era of Genomic and Personalized Medicine.", University of California, Davis, Molecular & Cellular Cardiology, Genome & Biomedical Sciences Facility, Davis, CA, 2009
"Stress Response (HSF1) and Oxido-Reductive Pathways as Drug Targets.", Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 2010
"Oxido-Reductive Stress: Novel Targets in Heart Failure.", BCVS: Genes, Proteins, and Cardiovascular Medicine. Session II: Pathways and Mechanisms for Better Therapies, Rancho Las Palmas Hotel, Rancho Mirage, CA (UCLA event), 2010
"Redox Signaling Networks Underlying Protein Disease in Flies and Mice.", NIA Seminar, Baltimore, MD, 2011
"Modeling Oxido-Reductive Stress Networks and Protein Aggregation Disease from Human to Mice and Flies (and back).", NIH Director's Pioneer Award Symposium, Bethesda, MD, 2011
"Oxido-Reductive Stress Signaling networks in the Heart.", NAVBO Workshops in Vascular Biology, Hyannia, MA, 2011
"Oxido-Reductive Stress & HSP Networks in Heart Diseases.", Keystone Symposia. Mechanisms of Cardiac Growth, Death, and Regeneration, Keystone, CO, 2011
"Oxido-Reductive Stress: A Novel Mechanism Underlying Heart Failure and Protein Aggregation Diseases.", American Physiology Society, Experimental Biology Conference, Washington, D.C., 2011
"Redox Signaling Networks and Protein-induced Heart Disease.", Inaugural Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Sanford School of Medicine, Vermillion, SD, 2011
"Regulation of Cardiac Signaling Mechanisms by Reductive Stress.", AHA Scientific Sessions, Orlando, FL, 2011
"Proteostasis and Redox Control in Health and Disease.", UCLA Distinguished Cardiovascular, UCLA, Los Angeles, California, 2012
“Cardiovascular Medicine in the 21st Century: Lessons from Randomized Trials to Stem Cells.”, Dean’s Distinguished Lecture Series, University of Kentucky College of Medicine, Lexington, Kentucky, 2012
“Models of inheritable protein misfolding cardiac diseases reveal new insights on redox metabolism”, Distinguished Scientist Seminar Series, University of South Alabama College of Medicine, Mobile, Alabama, 2012
“Proteostasis Pathways and Cardioprotection: 2012 and Beyond.”, The Cardioprotection Colloquium, University of California, Los Angeles, California, 2012
"Models of Inheritable Protein Misfolding Cardiac Diseases Reveal New Insights on Redox, UCSD Cardiovascular Science Conference Series, UCSD, La Jolla, California, 2012
"The Heart Failure Epidemic: New Insights and Strategies.", SSCI Presidential Symposium, Southern Regional Meetings, New Orleans, LA, 2012
"New Insights on the Myofibrillar Manifestations caused by human CryAB mutants.", Second Annual Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood, South, 2012
The Society for Free Radical Biology & Medicine's 20th Annual Meeting, San Antonio, TX, 11/2013
“Models of Inheritable Protein Misfolding Cardiac Diseases Reveal New Insights on Redox", Vascular Biology and Therapeutics/ Cardiology Research Seminar Series, Yale University, New Haven Connecticut, 2013
Myocardial Reductive Stress., AHA BCVS 2014, Paris Hotel; Las Vegas, NV, 07/2014
Resetting the Redox Spectrum: Oxido-Reductive Stress in Health and Disease, Redox Biology Retreat, Medical College of Wisconsin, 11/14/2014
The Reductive Stress Hypothesis and the Antioxidant Treatment Paradox, HRHR Symposium, Bethesda, MD, 12/15/2014
Mitochondrial-nuclear crosstalk and Precision Medicine in Heart Disease., Grand Rounds, Meharry Medical College, 02/22/2015
AHA Research Committee, American Heart Association Research Committee Meeting, Dallas, TX, 05/20/2015
Elucidating Environmental Dimensions of Neurological Disorders and Diseases: Understanding New Tools from Federal Chemical Testing Program, Environmental Defense Fund Meeting, UC Davis Conference Center. Davis, CA, 06/17/2015 - 06/19/2015
AHA Research Committee Update, AHA Board of Directors Meeting, Dallas, TX, 10/28/2015 - 10/29/2015
AHA Research Directions, AHA Scientific Sessions, Orlando, FL, 11/07/2015
Linking cellular metabolism to ischemic injury session (Abstract Oral Session AOS.04.04), AHA Scientific Sessions, Orlando, FL, 11/10/2015
Mitochondrial-nuclear Crosstalk and Oxido-Reductive Stress in Health and Disease, Cardiology Grand Rounds, University of Illinois at Chicago - College of Medicine, 01/28/2016
The Redox Biology Paradigm: New Insights and Perspectives, Southern Society of Clinical Investigation - Karl T. Weber Distinguished Lecture in CV Medicine, New Orleans, LA, 02/19/2016
The Redox Biology Paradigm: New Insights and Perspectives, Frontiers in Science Seminar, University of Michigan, 03/07/2016
Pathogenic mechanisms of protein-aggregation disorders shared with muscular dystrophy, New Directions in Biology and Disease of Skeletal Muscle, Orlando, FL, 06/29/2016 - 07/01/2016
The Flipside of Oxidative Stress: The Reductive Stress World, 2017 AUC Annual Meeting, Phoenix, AZ, 01/19/2017
“The Flipside of Oxidative Stress: The World of Reductive Stress”, Frontiers in Cardiovascular Science Talk, Stanford Cardiovascular Institute (CVI), 02/21/2017
“Protein Misfolding Diseases: Lessons from Alzheimer’s to Cardiomyopathy”, Grand Rounds, Department of Medicine, Johns Hopkins Hospital, School of Medicine, 04/12/2017 - 04/14/2017
Benjamin, Ivor, What Protein Misfolding Diseases from Alzheimer’s to Heart Failure Can Teach us About the “Brain-Heart Connectome?, Festschrift, Karl T. Weber, MD, University of Tennessee Health Science Center, 06/02/2017
Benjamin, Ivor, It takes a village: How to maintain your academic career, Basic Cardiovascular Scientific Sessions 2017, Portland, Oregon, 07/12/2017
Ivor Benjamin, Reductive Stress, AHA Scientific Sessions, Anaheim, CA, 11/12/2017
Benjamin, IJ, Regenerative Therapy in Cardiovascular Disease: How Do Cortical Bone Stem Cells Repair the Infarcted Heart?, Joint Symposium of the American Heart Association and the American College of Cardiology, Orlando, FL, 03/12/2018
Benjamin, Ivor, Reflections of a Cardiovascular Physician-Scientist, HBCU Scholars Lecture, Nashville, TN, 04/10/2018
The Care of the Future, AHA President's Dinner, Chicago, Illinois, 11/11/2018
"Heart & Brain Sciences, Health Equity and the AHA", Stanford-Duke Cardiovascular Symposium, San Jose, California, 11/29/2018
"Virtual Care - The Next Frontier?", National Quality Forum's 2019 Annual Conference, Washington, DC, 03/26/2019
 
International
"Regulation and Function of Stress Proteins During Ischemia", Hypoxia Symposia 1993, Lake Louise, Calgary, Canada, 1993
"Targeted disruption of the mammalian heat shock transcription factor 1 (mHSF) in the mouse.", International Congress of Stress, Budapest, Hungary, 1997
"Stress Proteins, Apoptosis in Pre-Natal Development, Cancer, and Medicine.", 5th IFTS International Federation of Teratology Societies, Sydney, Australia, 1997
"Developmental and Physiological Effects of Targeted HSF1 Gene Inactivation in Mice.", Chest Disease International Conference on Dynamics and Regulation of the Stress Response, Chest Disease Research Institute, Kyoto University, Kyoto, Japan, 1998
"Novel Pathways for HSP Mediated Cardioprotection.", XVII World Congress of the International Society for Heart Research, Winnipeg, Manitoba, Canada, 2001
"Molecular Chaperones (HSP) and the Control of Mitochondrial Permeability Transition and ROS Production.", Gordon Conference on Stress-Induced Gene Expression - Invited Speaker, Queen's College, Oxford University, United Kingdom, 2003
"Role of Reductive Stress in R120G CryAB Myofibrillar Disease", 6th International Workshop on the Molecular Biology of Stress Responses, Concepcion, Chile, 2006
"Crosstalk Between Stress Response Pathways and Mitochondria: An Overview.", 28th Annual Internal Society for Heart Research Meeting, Toronto, Canada, 2006
"Protein Aggregation Mechanisms: New lessons from Human alphaB-crystallin chaperonapathy in mice.", 2007 World Conference of Stress, Budapest, Hungary, 2007
"New Biosignatures for Protein Aggregation Diseases", Gordon Research Conference, Magdalen College, Oxford, United Kingdom, 2007
"Cardiovascular Diseases and Stress Response Pathways in the Genomic Era.", Zhongshan University Medical School, China, 2008
"Reductive Stress in the Pathogenesis of Protein Aggregation Disease.", Gordon Research Conference on Thiol-Based Redox Regulations & Signaling, Pisa, Italy, 2008
"Biosignatures for Heart Failure in the Genomic Era.", ESC Symposium, European Society of Cardiology, Rome, Italy, 2008
"Cardiovascular Diseases and Stress Response Pathways in the Genomic Era.", Nanjing Medical University, Jiangsu Province Hospital, China, 2008
"Cardiovascular Diseases and Stress Response Pathways in the Genomic Era, Changsha University, Hunan, China, 2008
"Cardiovascular Diseases and Stress Response Pathways in the Genomic Era.", Wujing University Medical School, China, 2008
"Cardiovascular Disease: A Global Epidemic and Clinical Update 2008.", Zhangjiajie People's Hospital, China, 2008
"Oxido-Reductive Stress in the Heart.", ESC Heart Failure Congress 2009, Nice, France, 2009
"Focus on Reductive Stress", ESC Congress 2009, Barcelona, Spain, 2009
"Reductive Stress: a New Planer in Human Cardiomyopathies.", The British Society for Cardiovascular Research, United Kingdom, 2009
"Redox and Nitrosativ Regulation of Cardiac Remodeling: Novel Therapeutic Approaches for Heart Failure.", Fondation Leducq Transatlantic Network of Excellence Meeting, London, UK, 2009
"Oxido-Reductive Stress in Protein Aggregation Disorders.", EMBO-FEB Conference Series, Dubrovnik, Croatia, 2009
"Oxido-Reductive Stress in the Heart.", Society for Heart Vascular Metabolism, Padova, Italy, 2009
"Detection, Treatment and Prevention of Protein Aggregation, Guest Speaker, PureTech Ventures, Berlin, Germany, 2010
"Small HSPs and Oxido-Reductive Stress in Health and Disease.", Cell Stress and Chaperones Workshop (CSSI), Seoul, South Korea, 2010
"Small HSPs in Health and Disease.", 8th International Workshop on the Biology of Stress Response, CSSI-KCSS Sessions, Daemyung Resort, Seorak Mt. Korea, 2010
"Detection Treatment and Prevention of Protein Aggregation Diseases Caused by Reductive Stress.", Guest Speaker, Pure Tech Ventures, Berlin, Germany, 2010
"Redox Signaling Networks Underlying Protein-Induced Diseases.", 5th International Congress on Stress Response in Biology and Medicine, Cell Stress Society International, Quebec City, Quebec, Canada, 2011
"Redox Signaling Networks Underlying Protein-induced Diseases in Flies and Mice", Gordon Research Conference - Stress Proteins in Growth, Development, and Disease, II Ciocco Hotel, Lucca, Italy, 2011
"Redox Stress Response Pathways: A Balancing Act with Rhythmic Moves", IX Cell Stress Society International Workshop on the Molecular Biology of Stress Responses, Porto Alegre, Brazil, 2012
"Heart dis-stress: 911 calls for the heat shock response", Cell Stress Society International, the Art of Living with Stress: a Lesson from Ferruccio Ritossa Symposium, Rome, Italy, 2013
Mitochondrial-nuclear crosstalk and Oxido-Reductive Stress in Health and Disease, First Adriatic Symposium, Split, Croatia, 08/23/2014
How Small HSPs are scaling Big Hurdles into the Clinic, CSSI small Hsp Workshop, Quebec, Canada, 10/03/2014
The Redox Biology Paradigm: Past, Present, and Future, Xth International Workshop on EPR in Biology and Medicine, Krakow, Poland, 10/04/2016
Pathogenic mechanisms of sHSP protein-aggregation disorders shared with muscular dystrophy, Second International Workshop on The small HSP World, Bertinoro, Italy, 10/12/2016
Benjamin, Ivor, Defensive proteostasis mechanisms involve complementary stress response pathways, The 8th International Congress on Stress Proteins in Biology and Medicine, Turku, Finland, 08/11/2017
Benjamin, Ivor, The Flipside of Oxidative Stress: The “Reductive Stress” World, Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies, Split, Croatia, 09/26/2017
"How to Transform Quality Science into Relevant Cardiovascular Breakthroughs", 73rd Congress Brazilian Society of Cardiology, Sao Paulo, Brazil, 09/15/2018
"Global Burden and Risk Factors for Hypertension in the Era of Precision Medicine", 73rd Congress Brazilian Society of Cardiology, Sao Paulo, Brazil, 09/16/2018
"Atrial Fibrillation: Global Challenges and Opportunities", Great Wall International Congress of Cardiology, Beijing, China, 10/12/2018
"Atrial Fibrillation: Global Challenges and Opportunities", World Congress of Cardiology and Cardiovascular Health, Dubai, UAE, 12/06/2018
"Atrial Fibrillation: Global Challenges and Opportunities", Italian Society of Cardiology Conference, Rome, Italy, 12/15/2018
Presidential Address, International Stroke Conference, Honolulu, Hawaii, 02/06/2019 - Present
"Heart & Brain Sciences: Global Health Equity and the AHA", The 83rd Annual Scientific Meeting of the Japanese Circulation Society, Yokohama, Japan, 03/30/2019
"Nuclear Factor Erythroid 2-related Factor - Friend or Foe in Cardiovascular Disease", The 83rd Annual Scientific Meeting of the Japanese Circulation Society, Yokohama, Japan, 03/31/2019
"Cardiovascular Diseases and the Emerging Role of Big Data to Improve Diagnosis and Outcomes", Israel Heart Society Conference, May 2019, Tel Aviv, Israel, 05/01/2019 - Present
"Opportunities for Tackling Health Disparities in the Americas", XXVII Interamerican Congress of Cardiology, Punta Cana, Dominican Republic, 05/17/2019
"Cardiovascular Disease: Changes and Opportunities in the 21st Century", XXVII Interamerican Congress of Cardiology, Punta Cana, Dominican Republic, 05/17/2019
 

COMMITTEE SERVICE:
Medical College of Wisconsin
1977 - 1978 Secretary, Grad Appeals' Committee, Hunter College
1977 - 1978 President, Black Science Student's Organization, Hunter College
1979 - 1981 Member, Executive Council and Class Representative, Medical Student Society, Johns Hopkins School of Medicine
1996 - 1999 Chair, Library Advisory Committee, Library Faculty Advisory Committee, University of Texas Southwestern Medical Center at Dallas
2003 - 2004 Co-Chair, Department Chair Search Committee, Physiology, University of Utah
2004 - 2005 Member, Strategic Planning Committee, Cardiovascular Services, University of Utah
2004 - 2005 Member, Health Sciences Center, Clinical Center Strategic Planning, University of Utah
2004 - 2005 Chair, Search Committee Division Chief of Pulmonary and Critical Care, Internal Medicine, University of Utah
 
Hospital
2007 - 2013 Volunteer Attending, Cardiology, George E. Wahlen Veterans Administration Medical Center
 

EXTRAMURAL TEACHING:
Medical Student Education
2006 - 2007 University of Utah, Internal Medicine, Instructor, INTMD 7050(1): Cardiovascular OS - 5 - Dilated Cardiomyopathy
2007 - 2009 University of Utah School of Medicine, Cardiovascular Organ System Course for Second Year Medical Students
2011 - 2012 University of Utah, Biochemistry, Primary Instructor, BIO C 7970(9): Thesis Research-Ph D, 3 SCH, 1 student
2011 - 2012 University of Utah, Biochemistry, Primary Instructor, BIO C 7040(6): Lab Resrch Conferences, 1 SCH, 1 student
2011 - 2012 University of Utah, Biochemistry, Primary Instructor, BIO C 7970(6): Thesis Research-Ph D, 8 SCH, 1 student
2012 University of Utah, Biochemistry, Primary Instructor, BIO C 7970(7): Thesis Research-Ph D, 8 SCH, 1 student
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Prasanna Marathe, Medical College of Wisconsin, 2014 - Present Mentorship
Jamison Gordon, Medical College of Wisconsin, 2015 Mentorship
Kia Semons-Booker, Medical College of Wisconsin, 06/2017 - 08/2017 Advisor
Xavier Sendaydiego, Medical College of Wisconsin, 2019 - Present Mentor
 
Graduate Students
PhD Students Advised
Nnamdi Uche, Medical College of Wisconsin, 2019 - Present
 
Clinical/Research Fellows
Kurt Kolander, PhD, Medical College of Wisconsin, 2013 - Present Postdoctoral Fellow
Mai Thao, PhD, Medical College of Wisconsin, 2014 - 2016 Postdoctoral Fellow
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Adrian Leday, 1998
Walter Prater, 1998
Neil Desai, 1999 Supervisor
Jake Doskocil, 1999 Supervisor
Tonya Watkins, SURF Program, 2001 Supervisor
Ahmad Price, SURF Program, 2002 Supervisor
Fay Fay Ye, 2008 Advisor/Mentor
Simran Kaur, 2010 Advisor//Mentor
Snehal Gajiwala, 2011 - 2013 Supervisor
Charles B. Junkins, University of Utah, 2012 Supervisor
 
Undergraduate Students
Pebble Brockette, 1994 - 1996 Supervisor
Hemali Shah, 2001 Supervisor
Jeremy Chidester, 2007 Advisor/Mentor
Graydon Taylor, University of Utah, 2009 - 2012 Supervisor
Srinivasan Rama Sreedharan, University of Utah, 2010 Advisor/Mentor
Claire Gentile, University of Utah, 2011 Supervisor
Jeffrey Lyon, University of Utah, 2011 Supervisor
Ali Sharif, University of Utah, 2011 Advisor/Mentor
Abner Mercado, NHLBI, 2011 - 2012 Advisor/Mentor
Scott Willie, University of Utah, 06/2012 - 08/2012 Research Internship
Melinda Choi, Marquette University/Medical College of Wisconsin, 2013 - 2016 Advisor/Mentor
Elizabeth Schibly, Marquette University, 2016 - Present Advisor/Mentor
 
Medical Students
Lie Shao, 1993 - 1995 Supervisor
Mildrede McAfee, 1993 Supervisor
Melinda Balabar, 1993 Supervisor
Carlton Bates, 1994 - 1995 Supervisor
Xiao-Xia Zuo, 1996 - 1999 Supervisor
Jan Kang, 1998 - 2001 Supervisor
Kenny Youens, 1999 Supervisor
Li Liu, 2000 - 2002 Supervisor
Anuj Patel, 2002 Supervisor
Jerry Chidester, 2005 - 2007 Supervisor
Landon Dickson, 2005 Supervisor
 
Graduate Students
PhD Students Advised
Katie Barber Mitzelfelt, University of Utah & Medical College of Wisconsin, 2011 - 10/17/2016 “Induced Pluripotent Stem Cells and Genome Engineering in the Study of the Human 343delT HSPB5 Chaperone Associated With Early-onset Skeletal Myopathy”
 
Clinical/Research Fellows
John Erikson, MD, PhD, UTHSCSA, 1992 - 1994 Supervisor
Jacqueline Brown, PhD, 1994 - 1996 Supervisor
D. Randy McMillian, PhD, Research Scientist, 1994 - 1998
Bishop Curry, DVM, 1996 - 1998 Supervisor
Xianzhong Xiao, PhD, 1996 - 1999 Supervisor
Alberta Davis, PhD, 1997 - 1999 Supervisor
Jaya Bhattacharyya, PhD, 1999 - 2000 Supervisor
Enrico Duru, PhD, 2000 Supervisor
Liang-Jun Yan, PhD, 2000 - 2003 Supervisor
Patrice Connell, PhD, 2000 - 2003 Supervisor
Elisabeth Christians, DVM, 2000 - 2003 Supervisor
Nancy Price, PhD, 2001 Supervisor
Gina Moore, PhD, 2002 - 2003 Supervisor
Sathya Srinivasan, PhD, 2003 - 2005 Supervisor
Rajasekaran Soorappan, PhD, 2003 - 2006 Supervisor
Ryan Taylor, PhD, 2004 - 2007 Supervisor
Muhammad Khan, MD, 2008 - 2010 Advisor/Mentor
Pat Limphong, University of Utah, 2009 - 2013 Advisor/Mentor
Lensey Scott, MD, University of Utah, 2009 - 2011 Advisor/Mentor
Huali Zhang, University of Utah, 2010 - 2012 Supervisor
Takahiro Ishiwata, University of Utah, 2010 - 2011 Supervisor
Michael Riedel, PhD, University of Utah & Medical College of WI, 2010 - 2015 Advisor/Mentor
Soumyajit Mustafi, University of Utah, 2010 - 2013 Supervisor
Shayne Squires, MD, University of Utah & Medical College of WI, 2011 - 2014 Supervisor
 
Faculty
Paul Long, University of Utah, 2010 - Present Supervisor
NHLBI eMentoring, NHLBI, 2010 - Present Advisor/Mentor
 

COMMUNITY SERVICE ACTIVITIES:
2004 - Present Member, Rotary Club, Rotary Club of Salt Lake City
2008 - 2012 Tutor, Franklin Elementary School, 6th Grade, Salt Lake City
2011 - Present Member, University of Michigan, National Advisory Council, Ann Arbor
2014 - Present Honorary Chair, Fellowship Open, Milwaukee, WI
07/15/2017 - Present Board of Trustees, Milwaukee Repertory Theater, Milwaukee, WI
 

SOCIAL MEDIA/NEWS PUBLICATIONS:
06/09/2017 "Researchers receive $1.5 million each to study extracellular matrix for cardiovascular research" - American Heart Association, The Paul G. Allen Frontiers Group fund research seeking next breakthrough. PRNewswire. https://www.prnewswire.com/news-releases/researchers-receive-15-million-each-to-study-extracellular-matrix-for-cardiovascular-research-300501786.html
06/30/2017 "Local cardiologist Ivor Benjamin to be next president of American Heart Association" Milwaukee Journal Sentinel https://www.jsonline.com/story/news/2017/06/30/local-cardiologist-ivor-benjamin-named-president-american-heart-association/442898001/
07/06/2017 https://www.biztimes.com/bubbler/ivor-j-benjamin/
04/30/2018 "Monday on Lake Effect: The State of Heart Research, Fit For You, the Health of Small Farming" - WUWM 89.7 - Milwaukee's npr http://wuwm.com/post/monday-lake-effect-state-heart-research-fit-you-health-small-farming#stream/0

US PATENT APPLICATION:
04/14/2014 Squires S., Benjamin I.J., ASSAY FOR DETERMINING RELATIVE REDOX CHANGES IN LIVING CELLS AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS. Patent Application 14/252,522.


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Dodoo, SN Benjamin, IJ. Genomic Approaches to Hypertension. Cardiology Clinics. 884(35) 2017 In Press.
2. Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM. Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. Stem Cell Reports. 2017 03 14;8(3):491-499. PMCID: PMC5355643
3. Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Glob Heart. 2017 12;12(4):341-348.
4. Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT. Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. Mol Cell Biol. 2016 09 15;36(18):2403-17. PMCID: PMC5007788
5. Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016 05;18(5):527-39. PMCID: PMC5341796
6. Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ. The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. J Biol Chem. 2016 07 15;291(29):14939-53. PMCID: PMC4946913
7. Hussein RM, Benjamin IJ, Kampinga HH. Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners. PLoS One. 2015;10(5):e0126761. PMCID: PMC4427338
8. Grose JH, Langston K, Wang X, Squires S, Mustafi SB, Hayes W, Neubert J, Fischer SK, Fasano M, Saunders GM, Dai Q, Christians E, Lewandowski ED, Ping P, Benjamin IJ. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. PLoS One. 2015;10(10):e0133994. PMCID: PMC4605610
9. Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ. Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports. 2014 Jul 08;3(1):131-41. PMCID: PMC4110777
10. Curley M, Berger M, Roth J, Benjamin I, Rubenstein J. Predictors of Mortality and Major In-Hospital Adverse Events Associated With Electrophysiology Catheter Ablation. JAMA Internal Medicine. 2014;174(5):815. doi:10.1001/jamainternmed.2014.415.
11. Christians ES, Mustafi SB, Benjamin IJ. Chaperones and cardiac misfolding protein diseases. Curr Protein Pept Sci. 2014 May;15(3):189-204.
12. Chai RC, Kouspou MM, Lang BJ, Nguyen CH, van der Kraan AG, Vieusseux JL, Lim RC, Gillespie MT, Benjamin IJ, Quinn JM, Price JT. Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. J Biol Chem. 2014 May 09;289(19):13602-14. PMCID: PMC4036365
13. Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians ES, Benjamin IJ. Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. Antioxid Redox Signal. 2014 Jun 20;20(18):2891-906. PMCID: PMC4039002
14. Benjamin I, Brown N, Burke G et al. American Heart Association Cardiovascular Genome-Phenome Study: Foundational Basis and Program. Circulation. 2014;131(1):100-112. doi:10.1161/circulationaha.114.014190.
15. Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer. 2014 Jan 07;110(1):71-82. PMCID: PMC3887302
16. Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W. Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med. 2014 Jan 01;189(1):96-103. PMCID: PMC3919126
17. Squires S, Christians E, Riedel M, Timothy D, Rodesch CK, Marvin J, Benjamin I. Effects of redox state on the efficient uptake of cell permeable Peptide in Mammalian cells. Open Biochem J. 2013;7:54-65. PMCID: PMC3731798
18. Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG. The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. PLoS Genet. 2013 Jun;9(6):e1003544. PMCID: PMC3688542
19. Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I. Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Transl Med. 2013 Mar;2(3):161-6. PMCID: PMC3659767
20. Brewer AC, Mustafi SB, Murray TV, Rajasekaran NS, Benjamin IJ. Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. Antioxid Redox Signal. 2013 Mar 20;18(9):1114-27. PMCID: PMC3567781
21. Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ. HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One. 2012;7(8):e42118. PMCID: PMC3411653
22. Christians ES, Ishiwata T, Benjamin IJ. Small heat shock proteins in redox metabolism: implications for cardiovascular diseases. Int J Biochem Cell Biol. 2012 Oct;44(10):1632-45. PMCID: PMC3412898
23. Benjamin IJ. Targeting endoglin, an auxiliary transforming growth factor β coreceptor, to prevent fibrosis and heart failure. Circulation. 2012 Jun 05;125(22):2689-91. PMCID: PMC3401168
24. Zhang H, Limphong P, Pieper J, Liu Q, Rodesch CK, Christians E, Benjamin IJ. Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity. FASEB J. 2012 Apr;26(4):1442-51. PMCID: PMC3316899
25. Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol. 2012 Mar;32(5):929-40. PMCID: PMC3295200
26. Christians ES, Benjamin IJ. Proteostasis and REDOX state in the heart. Am J Physiol Heart Circ Physiol. 2012 Jan 01;302(1):H24-37. PMCID: PMC3334238
27. Zhang Y, Ahn YH, Benjamin IJ, Honda T, Hicks RJ, Calabrese V, Cole PA, Dinkova-Kostova AT. HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol. 2011 Nov 23;18(11):1355-61. PMCID: PMC3302153
28. Tamaru T, Hattori M, Honda K, Benjamin I, Ozawa T, Takamatsu K. Synchronization of Circadian Per2 Rhythms and HSF1-BMAL1:CLOCK Interaction in Mouse Fibroblasts after Short-Term Heat Shock Pulse. PLoS ONE. 2011;6(9):e24521. doi:10.1371/journal.pone.0024521.
29. Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ. Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal. 2011 Mar 15;14(6):957-71. PMCID: PMC3113450
30. Zhang H, Rajasekaran NS, Orosz A, Xiao X, Rechsteiner M, Benjamin IJ. Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways. J Mol Cell Cardiol. 2010 Dec;49(6):918-30. PMCID: PMC2975794
31. Zhang X, Min X, Li C, Benjamin IJ, Qian B, Zhang X, Ding Z, Gao X, Yao Y, Ma Y, Cheng Y, Liu L. Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. Hypertension. 2010 Jun;55(6):1412-7.
32. Cooper ZA, Ghosh A, Gupta A, Maity T, Benjamin IJ, Vogel SN, Hasday JD, Singh IS. Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters. Am J Physiol Cell Physiol. 2010 Jan;298(1):C171-81. PMCID: PMC2806152
33. Rajasekaran NS, Firpo MA, Milash BA, Weiss RB, Benjamin IJ. Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. Physiol Genomics. 2008 Oct 08;35(2):165-72. PMCID: PMC2575954
34. Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50. PMCID: PMC2474535
35. Reinke H, Saini C, Fleury-Olela F, Dibner C, Benjamin IJ, Schibler U. Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev. 2008 Feb 01;22(3):331-45. PMCID: PMC2216693
36. Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008 Jan;22(1):84-92.
37. Ralser M, Benjamin IJ. Reductive stress on life span extension in C. elegans. BMC Res Notes. 2008 Jun 04;1:19. PMCID: PMC2518267
38. Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, Hester L, Benjamin IJ, He JR, Hasday JD. Heat shock co-activates interleukin-8 transcription. Am J Respir Cell Mol Biol. 2008 Aug;39(2):235-42. PMCID: PMC2542457
39. Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. PMCID: PMC3683980
40. Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10;130(3):427-39. PMCID: PMC2962423
41. Liu Y, Wang J, Yi Y, Zhang H, Liu J, Liu M, Yuan C, Tang D, Benjamin IJ, Xiao X. Induction of KLF4 in response to heat stress. Cell Stress Chaperones. 2006;11(4):379-89. PMCID: PMC1712684
42. Christians ES, Benjamin IJ. Heat shock response: lessons from mouse knockouts. Handb Exp Pharmacol. 2006(172):139-52.
43. Benjamin IJ. Viewing a stressful episode of ER: is ATF6 the triage nurse? Circ Res. 2006 May 12;98(9):1120-2.
44. Kadono T, Zhang XQ, Srinivasan S, Ishida H, Barry WH, Benjamin IJ. CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake. J Mol Cell Cardiol. 2006 Jun;40(6):783-9.
45. Kajiya H, Ito M, Ohshima H, Kenmotsu S, Ries WL, Benjamin IJ, Reddy SV. RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells. J Cell Biochem. 2006 Apr 15;97(6):1362-9.
46. Christians E, Benjamin IJ. A murine world without HSFs: meeting report. Cell Stress Chaperones. 2005;10(4):265-7. PMCID: PMC1283871
47. Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK. Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene. 2005 Sep 29;24(43):6564-73.
48. Kim HP, Wang X, Zhang J, Suh GY, Benjamin IJ, Ryter SW, Choi AM. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. J Immunol. 2005 Aug 15;175(4):2622-9.
49. Fairfield DA, Lomax MI, Dootz GA, Chen S, Galecki AT, Benjamin IJ, Dolan DF, Altschuler RA. Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation. J Neurosci Res. 2005 Aug 15;81(4):589-96.
50. Benjamin IJ, Arnett DK, Loscalzo J, American Heart Association Basic Science Writing Group. Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group. Circulation. 2005 Mar 15;111(10):e120-3.
51. Taylor RP, Benjamin IJ. Small heat shock proteins: a new classification scheme in mammals. J Mol Cell Cardiol. 2005 Mar;38(3):433-44.
52. Christians ES, Zhou Q, Renard J, Benjamin IJ. Heat shock proteins in mammalian development. Semin Cell Dev Biol. 2003 Oct;14(5):283-90.
53. Jennings AM, Lee SH, Benjamin IJ, Farrar RP. (2005). Small Heat Shock Proteins CRY AB/aB-Crystallin and HSPB2/MKBP are not Required for skeletal Muscle Adaption Following Resistance training in Mice. Am J Physiol Regul Integr Comp Physiol.
54. Wirth D, Christians E, Li X, Benjamin IJ, Gustin P. Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury. Toxicol Appl Pharmacol. 2003 Oct 01;192(1):12-20.
55. Williams RS, Benjamin IJ. Protective responses in the ischemic myocardium. J Clin Invest. 2000 Oct;106(7):813-8. PMCID: PMC381426
56. Christians E, Davis AA, Thomas SD, Benjamin IJ. Maternal effect of Hsf1 on reproductive success. Nature. 2000 Oct 12;407(6805):693-4.
57. Benjamin IJ, Schneider MD. Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest. 2005 Mar;115(3):495-9. PMCID: PMC1052014
58. Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ. Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):465-71.
59. Christians ES, Benjamin IJ. The stress or heat shock (HS) response: insights from transgenic mouse models. Methods. 2005 Feb;35(2):170-5.
60. Kim H, Wang X, Zhang J et al. Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of p38  MAPK and Heat Shock Factor-1. The Journal of Immunology. 2005;175(4):2622-2629. doi:10.4049/jimmunol.175.4.2622.
61. Rice P, Martin E, He J et al. Febrile-Range Hyperthermia Augments Neutrophil Accumulation and Enhances Lung Injury in Experimental Gram-Negative Bacterial Pneumonia. The Journal of Immunology. 2005;174(6):3676-3685. doi:10.4049/jimmunol.174.6.3676.
62. Liu L, Zhang HH, Ding GX, Cheng YL, Yan LJ, Benjamin IJ. [Effects of hsf1 genotype on the constitutive expression of alphaB-crystallin in mice myocardium]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 Feb;20(1):30-3.
63. Corey LL, Weirich CS, Benjamin IJ, Kingston RE. Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. Genes Dev. 2003 Jun 01;17(11):1392-401. PMCID: PMC196071
64. Zheng H, Benjamin IJ, Basu S, Li Z. Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. Eur J Immunol. 2003 Jun;33(6):1754-62.
65. Hargitai J, Lewis H, Boros I, Racz T, Fiser A, Kuruca I, Benjamin IJ, Vigh L, Penzes Z, Csermely P, Latchman DS. (2003). Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun, 307, 689-695.
66. Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin IJ, Miller JM, Lomax MI. Stress pathways in the rat cochlea and potential for protection from acquired deafness. Audiol Neurootol. 2002 May-Jun;7(3):152-6.
67. McMillan DR, Christians E, Forster M, Xiao X, Connell P, Plumier JC, Zuo X, Richardson J, Morgan S, Benjamin IJ. Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. Mol Cell Biol. 2002 Nov;22(22):8005-14. PMCID: PMC134743
68. Yan LJ, Christians ES, Liu L, Xiao X, Sohal RS, Benjamin IJ. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J. 2002 Oct 01;21(19):5164-72. PMCID: PMC129050
69. Benjamin IJ, Christians E. Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. Circ Res. 2002 May 03;90(8):833-5.
70. Christians ES, Yan LJ, Benjamin IJ. Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury. Crit Care Med. 2002 Jan;30(1 Supp):S43-S50.
71. Luft JC, Benjamin IJ, Mestril R, Dix DJ. Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest. Cell Stress Chaperones. 2001 Oct;6(4):326-36. PMCID: PMC434415
72. Benjamin IJ. Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease. J Investig Med. 2001 Sep;49(5):381-97.
73. Pirkkala L, Alastalo TP, Zuo X, Benjamin IJ, Sistonen L. Disruption of heat shock factor 1 reveals an essential role in the ubiquitin proteolytic pathway. Mol Cell Biol. 2000 Apr;20(8):2670-5. PMCID: PMC85482
74. Bagatell R, Paine-Murrieta GD, Taylor CW, Pulcini EJ, Akinaga S, Benjamin IJ, Whitesell L. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res. 2000 Aug;6(8):3312-8.
75. Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, Benjamin IJ. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 1999 Nov 01;18(21):5943-52. PMCID: PMC1171660
76. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 1999 Sep 07;100(10):1134-46.
77. Xiao X, Benjamin IJ. Stress-response proteins in cardiovascular disease. Am J Hum Genet. 1999 Mar;64(3):685-90. PMCID: PMC1377784
78. Benjamin IJ, McMillan DR. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res. 1998 Jul 27;83(2):117-32.
79. McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem. 1998 Mar 27;273(13):7523-8.
80. Zeng W, Lee GL, Yan M, Diaz J, Benjamin IJ, Marion CR, Kopito R, Freedman S, Cotton C, Muallem S, Thomas P. (1997). Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am J Physiol, 273, C442-C455.
81. Benjamin IJ, Shelton J, Garry DJ, Richardson JA. Temporospatial expression of the small HSP/alpha B-crystallin in cardiac and skeletal muscle during mouse development. Dev Dyn. 1997 Jan;208(1):75-84.
82. Neufer PD, Benjamin IJ. Differential expression of B-crystallin and Hsp27 in skeletal muscle during continuous contractile activity. Relationship to myogenic regulatory factors. J Biol Chem. 1996 Sep 27;271(39):24089-95.
83. Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS. Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. Am J Physiol. 1996 Dec;271(6 Pt 1):C1828-37.
84. Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2339-42. PMCID: PMC39797
85. Radford NB, Benjamin IJ. (1995). Heat Shock (Stress) Protein 70 and Cardioprotection. Cardiol Rev, 3, 324-331.
86. Williams RS, Thomas JA, Fina M, German Z, Benjamin IJ. Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. J Clin Invest. 1993 Jul;92(1):503-8. PMCID: PMC293638
87. Benjamin IJ. Stress proteins: is their application in clinical medicine on the horizon? Hepatology. 1993 Dec;18(6):1532-4.
88. Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. J Clin Invest. 1992 May;89(5):1685-9. PMCID: PMC443048
89. Tan LB, Benjamin IJ, Clark WA. beta Adrenergic receptor desensitisation may serve a cardioprotective role. Cardiovasc Res. 1992 Jun;26(6):608-14.
90. Williams RS, Benjamin IJ. Stress proteins and cardiovascular disease. Mol Biol Med. 1991 Apr;8(2):197-206.
91. Benjamin IJ, Kröger B, Williams RS. Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6263-7. PMCID: PMC54513
92. Benjamin IJ, Jalil JE, Tan LB, Cho K, Weber KT, Clark WA. Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res. 1989 Sep;65(3):657-70.
93. Weber KT, Sundram P, Reddy HK, Benjamin IJ. (1987). Current indications and future use of amrinone in acute and chronic cardiac failure. Pract Cardiol, June (Suppl), 3-13.
94. Benjamin IJ, Werth DK, Abrahams C, Weber KT. (1987). The cardiomyopathies. Diagnosis, 12, 18-32.
95. Black HR, Benjamin IJ, Moser M. (1984). Nutrition therapy for hypertension. Primary Cardiol, 10, 71-82.
96. Benjamin IJ, Schuster EH, Bulkley BH. Cardiac hypertrophy in idiopathic dilated congestive cardiomyopathy: a clinicopathologic study. Circulation. 1981 Sep;64(3):442-7.
97. Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM. The growing world of small heat shock proteins: from structure to functions. Cell Stress Chaperones. 2017 07;22(4):601-611. PMCID: PMC5465036
98. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Why publish in the <i>American Journal of Physiology-Heart and Circulatory Physiology</i>? Am J Physiol Heart Circ Physiol. 2017 08 01;313(2):H221-H223.
99. Dodoo SN, Benjamin IJ. Genomic Approaches to Hypertension. Cardiol Clin. 2017 May;35(2):185-196.
100. Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Correction for Gabai et al., "Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR". Mol Cell Biol. 2017 10 15;37(20). PMCID: PMC5615190
101. Kawamura G, Hattori M, Takamatsu K, Tsukada T, Ninomiya Y, Benjamin I, Sassone-Corsi P, Ozawa T, Tamaru T. Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress. Commun Biol. 2018;1:204. PMCID: PMC6250677
102. Cooperative interaction among BMAL1, HSF1, and p53 protects mammalian cells from UV stress. Kawamura G, Hattori M, Takamatsu K, Tsukada T, Ninomiya Y, Benjamin I, Sassone-Corsi P, Ozawa T, Tamaru T. Commun Biol. 2018 Nov 22;1:204. doi: 10.1038/s42003-018-0209-1. eCollection 2018. PMID: 30480104
103. Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. Ma X, Mani K, Liu H, Kovacs A, Murphy JT, Foroughi L, French BA, Weinheimer CJ, Kraja A, Benjamin IJ, Hill JA, Javaheri A, Diwan A. J Am Heart Assoc. 2019 Feb 19;8(4):e010866. doi: 10.1161/JAHA.118.010866. PMID: 30773991 Free PMC Article
 
Books, Chapters, and Reviews
1. Strande, J. L., Fasseas, P., & Benjamin, I. J. (2015). Pericardial and Myocardial Disease. In Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 136-144). Philadelphia, PA: Elsevier Health Sciences.
2. Benjamin, I. J., MD. (2015). Introduction to Molecular Medicine. In Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 2-14). Philadelphia, PA: Elsevier Health Sciences.
3. Benjamin, I. J., MD. (2015). Diagnostic Tests and Procedures in the Patient with Cardiovascular Disease. In Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 37-54). Philadelphia, PA: Elsevier Health Sciences.
4. Algahim, M. F., Love, R. B., & Benjamin, I. J. (2015). Other Cardiac Topics. In Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 145-158). Philadelphia, PA: Elsevier Health Sciences.
5. Lohr, N. L., MD, PhD, & Benjamin, I. J., MD. (2015). Structure and Function of the Normal Heart and Blood Vessels. In Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 16-21). Philadelphia, PA: Elsevier Health Sciences.
6. Gaglianello, N. A., MD. (2015). Heart Failure and Cardiomyopathy. In C. Mahr MD & I. J. Benjamin MD (Authors), Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 55-66). Philadelphia, PA: Elsevier Health Sciences.
7. Kleczka, J., MD. (2015). Evaluation of the Patient with Cardiovascular Disease. In I. J. Benjamin MD (Ed.), Andreoli and Carpenter's Cecil Essentials of Medicine (9th ed., pp. 22-36). Philadelphia, PA: Elsevier Health Sciences.
8. Benjamin I. Heart Failure. Genomic and Personalized Medicine, 2nd Edition 2013;2. DOI: http://dx.doi.org/10.1016/B978-0-12-382227-7.00048-3
9. Tamaru, T.; Hattori, M.; Ninomiya, Y.; Kawamura, G.; Varès, G.; Honda, K.; Mishra, D.P.; Wang, B.; Benjamin, I.; Sassone-Corsi, P. ROS stress resets circadian clocks to coordinate pro-survival signals. PLoS ONE , vol. 8 (2013)
10. Benjamin IJ, Gillespie HS. Infiltrative and Protein Misfolding Myocardial Diseases. In Hill JA, Olson EN (Eds.) Muscle: Fundamental Biology and Mechanisms of Disease. Elsevier. Muscle , vol. 1 (2012)
11. Benjamin IJ: (2011). Evaluation of the Patient with Cardiovascular Disease. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition, p. 32-45). Elsevier.
12. Benjamin IJ: (2011). Heart Failure and Cardiomyopathy. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition, pp. 66-74). Elsevier.
13. Benjamin IJ: (2010). Introduction to Molecular Medicine, Molecular Basis of Human Disease. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition, pp. 2-14). Elsevier.
14. Benjamin IJ, Bull D: (2010). Other Cardiac Topics. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition, pp. 156-164). Elsevier.
15. Benjamin IJ, Stehlik J: (2010). Pericardial and Myocardial Disease. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition, pp. 145-155). Elsevier.
16. Benjamin IJ, Morshedzadeh J, Li D: (2010). Structure and Function of the Normal Heart and Blood Vessels. In Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition). Elsevier.
17. Andreoli TE, Carpenter CCJ, Griggs RC, Benjamin IJ: (2010). Cell Essentials of Medicine (8th Edition). Philadelphia: W.B. Saunders.
18. Benjamin IJ, Patel J: (2007). Heart Failure in the Era of Genomic Medicine. In Willard H: Ginsburg G (Ed.), Genomic and Personalized Medicine, Two-Vol Set , (2009)
19. Benjamin IJ, Owan T. (2009). Race, Genetics and Cardiovascular Disease. In K.C. Ferdinand and A. Armani (Ed.). Cardiovascular Disease in Racial and Ethnic Minorities. Humana Press, a part of Springer Science+Business Media, LLC 2009.
20. Benjamin IJ, Bull DA: (2008). Other Topics in Cardiology. In DA Bill *IJ Benjamin (Ed.), Andreoli and Carpenter’s Cecil Essentials of Medicine (8th Edition). Elsevier.
21. McGann CJ, Gupta S, Benjamin IJ: (2008). Myocardial & Pericardial Disease. In Cecil Essential of Medicine (7th Edition).
22. Li D, Benjamin IJ: (2008). Structure and Function of the Normal Heart and Blood Vessels. In Andreoli and Carpenter’s Cecil Essentials of Medicine (6th Edition).
23. Benjamin IJ: (2007). Heart Failure and Cardiomyopathy. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs, and I. Benjamin (Eds.), Cecil Essentials of Medicine (7th Edition, pp. 68-76). Philadelphia: W.B. Saunders.
24. Benjamin IJ: (2007). Molecular Basis of Human Disease. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs, and I. Benjamin (Eds.), Cecil Essentials of Medicine (7th Edition, pp. 3-15). Philadelphia: W.B. Saunders.
25. Bull D, Benjamin IJ: (2007). Other Cardiac Topics. In T.E. Andreoli, Editor-in-Chief; Cecil Essentials of Medicine (7th Edition, pp. 158-166). Philadelphia: W.B. Saunders.
26. McGann CJ, Gupta S. Benjamin IJ: (2007). Pericardial and Myocardial Disease. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs, and I. Benjamin (Eds.), Cecil Essentials of Medicine (7th Edition, pp. 145-157). Philadelphia: W.B. Saunders.
27. Benjamin IJ: (2007). Evaluation of the Patient with Cardiovascular Disease. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs and I. Benjamin (Eds.), Cecil Essentials of Medicine (7th Edition, pp. 36- 49), Philadelphia: W.B. Saunders.
28. Andreoli TE, Carpenter CCJ, Griggs RC, Benjamin IJ: (2007). Cell Essentials of Medicine (7th Edition). Philadelphia: W.B. Saunders.
29. Orosz A, Benjamin IJ: (2007). Genetic Models of HSF Function. In M. Zouhair Atassi (Eds.). Cell Proteins (7). New York: Springer.
30. Li DY, Benjamin IJ: (2007). Structure and Function of the Normal Heart and Blood Vessels. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs, and I. Benjamin (Eds), Cecil Essentials of Medicine (7th Edition, pp. 27-35). Philadelphia: W.B. Saunders.
31. Benjamin IJ, Lange R, Hillis LD: (2004). Alcohol and Substance Abuse. In T.E. Andreoli, Editor-in-Chief; C.C.J. Carpenter, R.C. Griggs and J. Loscalzo (Eds.), Andreoli and Carpenter’s Cecil Essentials of Medicine (6th Edition, pp. 1111-1112). Philadelphia: Saunders.
32. Benjamin IJ, Williams RS: (1994). Expression and Function of Stress Proteins in the Ischemic Heart in Morimoto TI, Tissieres A, Goergopoulous CL (Eds.), The Biology of Heat Shock Proteins and Molecular Chaperones (pp. 533-552). Cold Spring Harbor Press.
 
Editorials, Letters to Editor, Other
1. Benjamin IJ: (1993). Stress proteins: is their application in clinical medicine on the horizon? Hepatology, 18(6), 1532-4.
2. Benjamin IJ, Christians E: (2002). Exercise, estrogen and ischemic cardioprotection by heat shock protein 70. Circ Res, 90(8), 833-5.
3. Benjamin IJ: (2006). Viewing a stressful episode of ER: is ATF6 the triage nurse? Circ Res, 98(9), 1120-2.
4. Benjamin IJ: (2012). Targeting Endoglin a TGFβ coreceptor, to prevent fibrosis and heart failure. Circulation, 125(22):2689-91.
 
Non-Refereed Journal Publications/Original Papers
1. Kim G, Meriin A, Gabai V, Christians E, Benjamin IJ, Wilson A, Wolozin B, Sherman M. The heat shock transcription factor Hsfl is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. vol. 11 (2012).
2. Benjamin IJ: (1993). Regulation and function of stress proteins during ischemia. In Sutton JR, Houston CS, Coates G (Eds.), Hypoxia and molecular medicine: proceedings of the 8th International Hypoxia Symposium held at Lake Louis, Canada, Queen City Printers Inc.
 
Abstracts
1. Marathe, P., Thao, M., & Benjamin, I. (2016). ID: 11: REDOX PROFILING OF CARVEDILOL AND PROPRANOLOL IN A HEART MODEL. Journal of Investigative Medicine, 64(4), 923. No PMCID.
2. Katie A. Mitzelfelt, Michael Riedel, Shuping Lai, Mai T. Thao, Qiang Dai, Melinda J. Choi, Lori L. Wallrath, Ivor J. Benjamin. (2016). Modeling Laminopathy-Linked Reductive Stress in iPSC-Derived Cardiomyocytes. Keystone Symposia 2016.
3. Jou J., Riedel M., Bowles N., Arrington C., Bley S., Kennedy B., Yandell M., Etheridge S., Saarel E., Pilcher T., Lai S., Pribble C., Bacon B., Saunders J.,Meyers L., Lopez-Izquierdo A., Cho S., Knight S., Muhlestein J., Carlquist J., Anderson J., Benjamin I.J., Tristani-Firouzi M. (2014). A Near-infrared Fluorescent Voltage-sensitive Dye Allows For Moderate-throughput Electrophysiological Analyses Of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes. American Journal of Physiology - Heart and Circulatory Physiology , vol. 307.
4. Jou J., Riedel M., Bowles N., Arrington C., Bley S., Kennedy B., Yandell M., Etheridge S., Saarel E., Pilcher T., Lai S., Pribble C., Bacon B., Saunders J.,Meyers L., Lopez-Izquierdo A., Cho S., Knight S., Muhlestein J., Carlquist J., Anderson J., Benjamin I.J., Tristani-Firouzi M. (2014). Human induced pluripotent stem cell-derived cardiomyocytes recapitulate clinical phenotypes in a multigenerational family with early onset atrial fibrillation and Long QT Syndrome. AHA Scientific Sessions 2014.
5. Thao M., Riedel M., Zielonka J., Vasquez-Vivar J., Hogg N., Kalyanaraman B., Benjamin I.J. (2014). Imaging the Dynamic Redox Changes of Endoplasmic Reticulum with Green Fluorescent Protein. Society for Free Radical Biology and Medicine Conference.
6. Kwok W., Lai S., Riedel M., Kolander K., Jou J., Tristani-Firouzi M., Liang M., Lough J., Benjamin I.J. (2014). Disease Modeling of Atrial Fibrillation using Patient-specific induced Pluripotent Stem Cell-derived Cardiomyocytes. Research Day 2014.
7. Lopez-Izquierdo A,Warren M, Reidel M, Cho S, Lai S, Lux R, Spitzer K, Benjamin IJ, Tristani-Firouzi M, and Jou C: (2014). A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput analyses of human induced pluripotent stem cell-derived cardiomyocytes [Abstract]. American Journal of Physiology - Heart and Circulatory Physiology.
8. Ishiwata T, Orosz A, Wang X, Scott L, Banerjee Mustafi S, Pratt G, Christians E, Boudina S, Abel D, Benjamin IJ: (2011). Cardiac Specific Heat Shock Protein B2 (HSPB2) Exerts Paradoxical Cardioprotection against Pressure Overload and Ischemic/Reperfusion in Mice. Circulation 124:A16342
9. Zhang H, Limphong P, Pieper J, El Chaar N, Benjamin IJ: (In Press). Regulations of Mitochondria Redox State by GSH Repletion Triggers Cell Death [Abstract].
10. Khanderao GD, Davidson CJ, Varadharaj S, Benjamin IJ, Soorappan RN: (2010). Effect of Bosentan on Reductive Stress Induced Endothelin-1/eNOS Dysfunction in Cardiomyocytes [Abstract]. The FASEB Journal, (24), 1001.14.
11. Kamalanaadhan S, Gayatri DK, Kannan S, Davidson C, Symons J, Firpo M, Benjamin IJ, Namakkal SR: (03/09/2010). Role of Nrf2/ARE Signaling in Age Dependent Cardiac Defense System [Abstract]. Presented in the Aging Center of Utah Retreat.
12. Soorappan RN, Varadharaj S, Khanderao GD, Davidson CJ, Zweier JL, Benjamin IJ: (2009). Oxidative Stress and Activation of Nrf2 Precedes the Pathogenic Transition of Reductive Stress-Induced Cardiomyopathy in Mice [Abstract]. FRBM, 47(2).
13. Rajasekaran NS, Block K, Varadharaj S, Davidson CJ, Jones DP, Zweier JL, Benjamin IJ: (2009). Mechanism for hR120GCryAB Cardiomyopathy in Mice [Abstract]. Circulation Research.
14. Zhang H, Rajasekaran NS, Orosz A, Schubert HL, Zhang XQ, Xiao X, Benjamin IJ: (2009). Molecular Features of Hsp25 on Protein Aggregate Suggest Multiple Pathogenic Consequences Among Human Disease-Causing CryAb Mutations [Abstract]. Circulation Research.
15. Limphong P, Zhang H, Cheng P, Riedel M, Christians E, Taylor G, Liu Q, Arnold J, Ivey K, Conklin B, Winge D, Srivastava D, Benjamin IJ. Modeling Human Myofibrillar Desmin-related Cardiomyopathy with Induced Pluripotent Stem Cells. Proceedings of the National Academy of Sciences of the United States of America, vol. 105 (2008).
 
Non-Peer Reviewed Educational Products
1. Gajiwala S, Barber K, Wang X, Benjamin IJ: (August 2011). Spatial and Temporal Analysis of Monocyte Infiltration into the Heart from the Spleen after Myocardial Infarction in Mice. Poster session presented at University of Utah Biology Department, Salt Lake City.
2. Benjamin, IJ., Closing the Gap in African-American Cardiovascular Health Disparities Helps Open Up Health Equity. AHA Centers for Health Metrics and Evaluation; Commentary; Oct 23 2017
 
Database, Video, or Other Research/Clinical Contributions
1. Benjamin IJ, Jo H, Holliday C, Miller J. (08/2011). Discussion of “Discovery of Sher- and Side-specific miRNAs and mRNAs in Human Aortic Valvular Endothelial Cells” by Casey Holliday, Am J Physiol Heart Circ Physiol., June 24, 2011 [Podcast]. Bethesda, MD: AJP. Available: http://ajpheart.podbean.com/.
2. Benjamin IJ, Taylor B, Weintraub N: (2011). Discussion of ‘Catalase overexpression in aortic smooth muscle prevents pathological mechanical changes underlying abdominal aortic aneurysm formation’ by Kathryn Maiellaro-Rafferty, Am J Physiol Heart Circ, May 6, 2011 (Ms # H-00040-2011R1) [Podcast]. Bethesda, MD: AJP. Available: http://ajpheart.podbean.com/.
 

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