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CURRICULUM VITAE

Jeffrey L. Segar MD
Professor
Department of Pediatrics
Division of Neonatology

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
1978 - 1980 Cornell University, Ithaka, NY
1980 - 1982 B.S Zoology, University of Wisconsin, Madison
1982 - 1986 M.D. Medicine, University of Wisconsin, Madison

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1986 - 1989 Residency, Pediatrics, University of Iowa, Iowa City, IA
1989 - 1992 Fellow, Neonatology, University of Iowa, Iowa City, IA

FACULTY APPOINTMENTS:
11/1992 - 06/1998 Assistant Professor of Pediatrics, University of Iowa, Iowa City, IA
07/1998 - 06/2004 Associate Professor of Pediatrics, University of Iowa, Iowa City, IA
07/1999 - 2006 Medical Director, Pediatric ECMO Service, University of Iowa, Iowa City, IA
07/2002 - 12/2002 Visiting Associate Professor, Department of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
07/2004 - 04/2019 Professor of Pediatrics, University of Iowa, Iowa City, IA
01/2006 - 12/2016 Director, Division of Neonatology, University of Iowa, Iowa City, IA
05/2011 - 04/2019 Director, Iowa Statewide Perinatal Care Program, Iowa Department of Public Health, IA
04/2013 - 04/2015 Vice Chair for Education, Pediatrics, University of Iowa, Iowa City, IA
04/2019 - Present Professor, Associate Chair, Pediatrics, Medical College of WI, Milwaukee, WI
11/2019 - Present Chief (Interim), Division of Adolescent Medicine, Medical College of WI, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
1993 - 1995 Mentor for Undergraduate Scholar Assistantship Program, University of Iowa
1993 - 1998 Pediatric Therapy 090: 242 (1 lecture, 3 h), Biannual seminars in neonatal physiology, University of Iowa
1996 - 1997 Mentor for Undergraduate Scholar Assistantship Program, University of Iowa
1997 - 1998 Facilitator, Foundations for Clinical Practice, Case-Based Learning I (CBLI), Fall, 1997, University of Iowa
1998 - 1999 Clinician Mentor, Introduction to Clinical Disciplines, University of Iowa
1999 - 2010 Seminars on shock, resuscitation, neonatal pharmacology and ECMO for NICU nurse practitioners, University of Iowa
1999 - Present Lectures in Pediatric Residents Core Lecture Series, University of Iowa
2000 - 2001 Facilitator, Foundations for Clinical Practice, Case-Based Learning I (CBLII), University of Iowa
2001 - 2002 Clinician Mentor, Foundations of Clinical Practice, Spring 2002, University of Iowa
2003 - 2004 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2004, University of Iowa
2004 - 2005 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2005, University of Iowa
2005 - 2006 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2006, University of Iowa
2006 - 2007 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2007, University of Iowa
2010 - 2011 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2011, University of Iowa
2011 - 2012 Facilitator, Foundations for Clinical Practice, Case-Based Learning II(CBLII), Spring 2012, University of Iowa
2012 - 2013 Facilitator, Foundations for Clinical Practice, Case-Based Learning II (CBLII), Spring 2013, University of Iowa
2013 - 2014 Facilitator, Medicine and Society I, Fall 2013, University of Iowa
2013 - 2014 Facilitator, Medicine and Society II, Case-Based Learning II(CBL II), Spring 2014, University of Iowa
2014 - 2015 Facilitator, Medicine and Society II, Case-Based Learning II (CBL II), Spring 2015, University of Iowa
2014 - 2015 Facilitator, Medicine and Society I, Fall 2014, University of Iowa
2015 - 2019 Annual Lecturer, MOHD 3 course. “Fetal and Transitional Physiology”, “Fetal Toxicology and Teratogens”, University of Iowa
2015 - 2016 Facilitator, Medicine and Society II, Case-Based Learning II (CBL II), Spring 2016, University of Iowa
2016 - 2017 2016-2017 Facilitator, Medicine and Society II, Case-Based Learning I (CBL II), Spring 2017, University of Iowa
2017 Facilitator, Medicine and Society II, Case-Based Learning I CBL I), Fall 2017, University of Iowa

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
1990 Attending Neonatologist, Pediatrics, Neonatology, University of Iowa
1995 - 1996 Attending physician, Pediatrics, Pediatric ICU, University of Iowa
1995 ECMO Neonatologist, Pediatrics, Neonatology, University of Iowa
1998 - 2006 Medical Director, ECMO Program, Pediatrics, Neonatology, University of Iowa
2019 - Present Attending Neonatologist, Pediatrics, Neonatology, Medical College of Wisconsin

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
1989
None
 
Certificates
Issued By Issue DateExpiration
Neonatal-Perinatal Medicine
1993
None
Recertification, Neonatal-Perinatal Medicine
2000
None
Recertification, Neonatal-Perinatal Medicine
2007
None
Recertification, Neonatal-Perinatal Medicine
2017
None
 

Licensure
Number Issue DateExpiration
Iowa, Permanent
#26987
1989
None
Wisconsin, Permanent
#70551-20
2019
None
 

AWARDS AND HONORS:
1986 Graduated with Honors, University of Wisconsin School of Medicine
1989 - 1990 Training Grant, American Heart Association, Iowa Affiliate, IA-89-F-9
1990 - 1993 Individual National Research Service Award, NIH, F32 HL-08170
1998 - Present , Included in Best Doctors in America
2004 - Present , Included in Guide to America’s Top Pediatricians
2015 Founders Award, Midwest Society for Pediatric Research

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1986 - Present American Academy of Pediatrics (Member )
1994 - Present Midwest Society for Pediatric Research (Member)
1995 - Present Society for Pediatric Research (Member)
1995 Council for High Blood Pressure Research (Fellow)
1997 - Present Perinatal Research Society (Member)
1998 - Present American Physiological Society (Member)
2005 - Present American Pediatric Society (Member )
2008 - 2009 Perinatal Research Society (President)
2011 - 2019 Iowa Statewide Perinatal Care Program (Director)
2016 - 2017 Midwest Society for Pediatric Research (President )

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
1998 - Present Editorial Board, American Journal of Physiology: Regulatory, Integrative & Comparative Physiology.
Ad-Hoc Reviewer
1998 - Present Journal of Applied Physiology, Journal of Developmental Pharmacology & Therapeutics, Pediatric Nephrology,Pediatric Research,J Physiology,Neonatology,Life Sciences,others
1998 - Present American Journal of Physiology (Heart Circ Physiol), Archives of Pediatrics & Adolescent Medicine, Brain Research,Cardiovascular Research, Circulation, Circulation Research, Hypertension,

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2003 - 2019 Research Committee, University of Iowa
2003 - 2006 Admissions Committee, University of Iowa
2003 - 2004 Commercial Payors Contracting Committee, University of Iowa
2004 - 2005 Review and Search Committee for Head, Department of Surgery, University of Iowa
2005 Department of Psychiatry Departmental Review, University of Iowa
2005 - 2011 Executive Committee, University of Iowa
2006 - 2011 Physicians Finance Committee, University of Iowa
2008 - 2009 Department of Microbiology Departmental Review, University of Iowa
2008 - 2012 Executive Director, Search Committee, University of Iowa Children’s Hospital
2009 - 2019 Medical Student Appeals Committee, University of Iowa
2009 - 2011 Admissions Committee, University of Iowa
2011 - 2012 Search Committee for Head, Department of Emergency Medicine, University of Iowa
2011 Committee Member, Department of Otolaryngology Departmental Review, University of Iowa
2013 - 2019 Participant, Community & STEM Education Programs, University of Iowa – meet with high school students several times a year to provide overview of pediatric medicine, University of Iowa
2014 - 2015 Search Committee for Head, Department of Anesthesia, University of Iowa
2016 - 2019 Continuing Medical Education Committee, University of Iowa
2016 - 2018 Admissions Committee, University of Iowa

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Fenoldopam to prevent renal dysfunction in indomethacin treated preterm infants
Source:
NIH
Role:
Co- Investigator
PI:
(Relinquished PI as of 04/01/2109 due to relocation)
Dates:
08/2018 - 09/2020
Direct Funds:
$275,000 (R21)
 
Non-Peer Review
Title:
Physiological approach to sodium supplementation in preterm infants
Source:
Thrasher Research Fund
PI:
G. Sokol
Dates:
03/2019 - 09/2021
Direct Funds:
$400,000
 
Prior
Peer Review
Title:
Regulation of Arterial Baroreflex During Development
Source:
NIH
PI:
J.L. Segar
Dates:
03/1993 - 02/1998
Direct Funds:
$450,419 (K08)
 
Title:
Ontogeny of the Sympathetic Control of Circulation
Source:
AHA
PI:
J.L. Segar
Dates:
07/1995 - 06/1998
Direct Funds:
$119,883 (Grant-in-Aid 9501289)
 
Title:
Glucocorticoids and Reflex Control of Autonomic Functions
Source:
AHA
Role:
Support relinquished 3/1/99 due to overlap with NIH HL59939
PI:
J.L. Segar
Dates:
01/1998 - 12/2001
Direct Funds:
$74,791 (Established Investigator Award 9740067N)
 
Title:
Ontogeny and Hormonal Control of Cardiac NADH shuttles
Source:
NIH
Role:
Co-investigator
PI:
T.D. Scholz, M.D.
Dates:
01/1998 - 12/2001
Direct Funds:
$350,000 (R29)
 
Title:
Regulation of the Sympathetic Excitatory Response at Birth
Source:
NIH
PI:
J.L. Segar
Dates:
04/1998 - 03/2002
Direct Funds:
$699,842 (R01)
 
Title:
Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
Source:
NIH
PI:
J.L. Segar
Dates:
07/2001 - 06/2005
Direct Funds:
$1,000,000 (R01)
 
Title:
Early Postoperative Apoptosis After Cardiac Surgery In the Neonate
Source:
AHA
PI:
C.A. Caldarone
Dates:
01/2002 - 12/2006
Direct Funds:
$260,000 (Scientist Development Grant)
 
Title:
Kidney Development during Normal and Pathological
Source:
NIH University of Iowa subcontract with Univ. of Virginia
Role:
Co-investigator
PI:
J.R. Robillard
Dates:
04/2002 - 03/2007
Direct Funds:
$770,344 (P50)
 
Title:
Ontogeny and Hormonal Control of Cardiac NADH shuttles
Source:
NIH
Role:
Co-investigator
PI:
T.D. Scholz, M.D.
Dates:
04/2003 - 03/2007
Direct Funds:
$1,100,000 (R01)
 
Title:
Fetal Programming of Coronary Artery Disease
Source:
NIH
PI:
J.L. Segar
Dates:
05/2003 - 04/2006
Direct Funds:
$285,000 (R21)
 
Title:
Mechanisms of Cardiac Remodeling in Offspring of Diabetic Mothers
Source:
NIH
PI:
T. D. Scholz
Dates:
02/2006 - 11/2010
Direct Funds:
$200,000 (R01)
 
Title:
Regulation of Fetal Myocyte Development
Source:
NIH
PI:
J.L. Segar
Dates:
01/2007 - 12/2011
Direct Funds:
$250,000 (R01)
 
Title:
Multi-Center Trial of Limiting PGY 2 & 3 Resident Work Hours on Patient Safety
Source:
NIH
PI:
J.L. Segar
Dates:
09/2012 - 01/2018
 
Non-Peer Review
Title:
A Phase 2 Multicenter, Single Dose, Randomized, Double Blind, Placebo Controlled, Parallel Group Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination with Phototherapy in Neonates
Source:
InfaCare Pharmaceutical Corp
PI:
J.L. Segar
Dates:
2014 - 2016
 
Title:
Statewide Perinatal Care Program
Source:
Iowa Department of Public Health
Role:
Program Director
Dates:
10/2017 - 09/2018
Direct Funds:
$344,253
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
National
Mechanisms regulating arterial baroreflex during development. Brody Memorial Colloquium on Brain, Body Fluids and Blood Pressure, University of Iowa Cardiovascular Center, 10/1992
Birth related changes in renal sympathetic nerve activity. Brody Research Colloquium on Brain, Body Fluid Balance and Blood Pressure., University of Iowa Cardiovascular Center, 10/1993
Role and regulation of angiotensin type 1 receptors in pressure overload induced cardiac hypertrophy in fetal sheep, Aspen Conference on Perinatal Research, 09/10/1996 - 09/12/1996
Ontogeny of arterial baroreflex function during development, FASEB Conference on Perinatal Regulation of the Cardiovascular System., Copper Mountain, Co, 08/17/1997 - 08/22/1997
Regulation of sympathetic activity at birth., Cornell University, 12/16/1999 - 12/17/1999
Regulation of sympathetic responses at birth., FASEB Conference on Perinatal Regulation of the Cardiovascular System., Copper Mountain, CO, 06/04/2000 - 06/09/2000
Fetal origins of adult disease, Committee on Research, American Academy of Pediatrics, Chicago, IL, 06/16/2001
Regulation of autonomic responses at birth, University of Texas, San Antonio Department of Physiology Research Conference., 10/29/2001
Fetal origins of adult diseases, University of Michigan, Department of Pediatrics Grand Rounds., 02/07/2002
Role of glucocorticoids in fetal and neonatal neural control of the circulation, FASEB Summer Research Conference on Neural Control of the Circulation, Snowmass, CO, 07/25/2004 - 07/29/2004
Programming of coronary artery dysfunction., Fetal Physiology Satellite Symposium; 2005 Annual Meeting of the Society for Gynecological Investigation., Los Angeles, CA, 03/23/2005
Glucocorticoids and cardiovascular development: Perturbing the fetal environment., Jerry Elliott Memorial Lectureship, South Central Conference of Perinatal Research, Austin, TX, 10/25/2005 - 10/27/2005
Cardiovascular Development: Role of glucocorticoids, Jerry Elliott Memorial Lectureship, Midwest Conference of Perinatal Research., College Corner, OH, 09/19/2006 - 09/21/2006
Developmental Origins of Adult Disease., The Gilbert-Barness Lectureship, Departments of Pathology and Pediatrics, University of Wisconsin, Madison, WI, 05/03/2007
Developmental Origins of Coronary Artery Disease., Western Pharmacology Society Annual Meeting, Waikoloa, HI, 01/28/2008
Intrauterine Development Programs Cardiovascular Disease, Grand Rounds, Indiana University Department of Pediatrics., 02/12/2009
Intrauterine Development Programs Cardiovascular Disease, Department of Pediatrics, University of Utah, 03/01/2010
Gestation Diabetes: Not a Sweet Deal for the Offspring., Department of Pediatrics, University of Utah, 03/02/2010
The biggest risk factor for coronary artery disease may be your mother, The Heart Research Center, Oregon Health & Sciences University, 03/10/2010
Neonatal Hemodynamics – does anybody know what is going on?, Department of Pediatrics, Case Western Reserve University., 03/26/2010
Gestational Diabetes – Long term effects on the offspring, Department of Pediatrics, Case Western Reserve University., 03/26/2010
Gestational Diabetes – Impact on the Offspring., Division of Neonatology Research Conference, Children’s Mercy Hospital., 05/07/2012
Early Origins of Cardiovascular Disease: a neonatologist in a cardiologist’s world., Department of Pediatrics, Children’s Mercy Hospital, 05/07/2012
Gestational Diabetes – Impact on Offspring Physiology., Jerry Elliott Memorial Lectureship, Midwest Conference of Perinatal Research, Chicago, IL, 09/10/2012
Perinatal Influences on Heart Growth and Function, AAP 83rd Perinatal and Developmental Medicine Symposium., Marco Island, FL, 11/07/2013
Gestational Diabetes: Cardiovascular Implications for the Offspring., AAP 83rd Perinatal and Developmental Medicine Symposium, Marco Island, FL, 11/08/2013
Hyperglycemia and Sex Specific Cardiovascular Programming, Annual Meeting, American Society for Pharmacology and Experimental Therapeutics, San Diego, CA, 04/28/2014
Sex Specific Programming of Hypertension, 2016 FASEB Science Research Conference., Big Sky, MT, 06/21/2016
Salt and the Neonate: Friend or Foe., Central Conference on Perinatal Research., Hershey, PA, 09/26/2016
Soggy or Dry – What’s the Most Appropriate?, NEO Conference, Orlando, FL, 02/23/2017
Salt and the Neonate: Friend or Foe., Department of Pediatrics Grand Rounds. Children’s Hospital of Wisconsin, Milwaukee, WI, 03/03/2017
Impact of Kidney Development on Postnatal Growth, 2018 Minnesota Neonatal Nutrition Conference., Minneapolis, MN, 10/05/2018
 
International
Regulation of sympathetic activity at birth, University of New South Wales, Department of Physiology and Pharmacology Seminar Program, 08/13/2002
Programming Alters Reactive Oxygen Species Signaling in the Cardiovascular System., 5th International Congress on Developmental Origins of Health and Disease, Perth Australia, 11/06/2007
Conference Leader and Speaker: “New Challenges in Advance of Neonatology”, Riga, Latvia, 08/14/2015 - 08/18/2015
Conference on Clinical Neonatology, Issa Trust Foundation, Annotto Bay, Jamaica, 11/01/2015 - 11/04/2015
Pediatric Education Conference, Ocho Rios, Jamaica, 07/18/2016 - 07/22/2016
Ipokrates Seminar, Porto Portugal, 04/01/2019 - 04/02/2019
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2019 - Present Advisor Committees Liaison, Social Determinants of Health
 
Hospital
1995 - 2008 Resident Education Committee, University of Iowa
1998 - 2005 Resident Selection Committee, University of Iowa
2005 - 2017 Promotions Advisory Committee, University of Iowa
2005 - Present CMN Advisory Panel, University of Iowa Children’s Hospital
2013 - 2019 Education Committee, University of Iowa
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Student
1992 - Present Neonatal Resuscitation and Pediatric Life Support Instructor
 
 
 
 

NATIONAL COMMITTEES:
1996 Moderator, platform session: Roles of peptides in the regulation of vascular tone during development, annual meeting of the Society for Pediatric Research
2004 Moderator, poster symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2005 - 2016 Pediatric Academic Societies Abstract Selection Committee
2005 Moderator, Satellite symposium. The Prenatal Environment, Programming and Postnatal Consequences. Sponsored by IUPS and the American Physiological Society. March 29-31, 2005. San Diego, CA
2006 - 2010 Council, Perinatal Research Society (President 2008-2009)
2006 Moderator, poster symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2007 Moderator, poster symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2008 Moderator, poster symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2010 Moderator, topic symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2011 Moderator, Plenary Session III: Programming in the Preterm Infant. 7th World Congress on Developmental Origins of Health and Disease. September 18-21, 2011.
2011 Moderator, topic symposium: Fetal Programming of Adult Diseases,annual meeting of the Pediatric Academic Societies
2014 Moderator, topic symposium: Neonatal Cardiology, annual meeting of the Pediatric Academic Societies

REVIEW PANELS:
1998 Ad Hoc member NIH Human Embryology and Development Study Section (HED-1)
2001 Member, National Institute of Child Health and Human Development Special Emphasis Panel (ZHD1 MCHG-B)
2003 Ad Hoc member NIH Pregnancy and Neonatology Study Section (PN1)
2004 Ad hoc member, American Heart Association Peer Review Committee, Cardiovascular Development
2004 Member, National Institute of Environmental Health Sciences Special Review Panel (ZRG1 EMNR-J50)
2005 - 2008 Ad Hoc reviewer, Canadian Institutes of Health Research
2006 - 2007 Ad Hoc reviewer, Australian National Health Medical Research Council
2008 - 2010 Member, Canadian Institutes of Health Research Clinical Investigation - Committee A
2009 Ad Hoc member NIH Pregnancy and Neonatology Study Section(PN1)
2013 Ad Hoc member NIH Pregnancy and Neonatology Study Section(PN1)
2015 Member, National Institutes of Health Special Emphasis Panel (ZRG1 EMNR –W55)
2016 Member, National Institutes of Health Special Emphasis Panel (ZRG1 EMNR –B(02)M)
2017 Member, National Institutes of Health Special Emphasis Panel (ZRG1 EMNR –S(02))
2018 Reviewer, Canadian Institutes of Health Research Clinical Investigation – Clinical Investigation A Committee
2019 Member, National Institutes of Health Special Emphasis Panel(ZRG1 EMNR –S(55))


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Smith FG, Smith BA, Segar JL, Robillard JE. Endocrine effects of ventilation, oxygenation and cord occlusion in near-term fetal sheep. J Dev Physiol. 1991;15:133-8.
2. Robillard JE, Smith FG, Segar JL, Guillery EN, Jose PA. Mechanisms regulating renal sodium excretion during development. Pediatr Nephrol. 1992;6:205-13.
3. Robillard JE, Segar JL, Smith FG, Jose PA. Regulation of sodium metabolism and extracellular fluid volume during development. Clin Perinatol. 1992;19:15-31.
4. Page WV, Perlman S, Smith FG, Segar JL, Robillard JE. Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. Am J Physiol. 1992;262:R459-63
5. Segar JL, Robillard JE, Johnson KJ, Bell EF, Chemtob S. Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia. J Pediatr. 1992;120:966-73.
6. Segar JL, Smith FG, Guillery EN, Jose PA, Robillard JE. Ontogeny of renal response to specific dopamine DA1-receptor stimulation in sheep. Am J Physiol. 1992;263:R868-73.
7. Segar JL, Hajduczok G, Smith BA, Merrill DC, Robillard JE. Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate. Am J Physiol. 1992;263:H1819-26.
8. Malcolm DD, Segar JL, Robillard JE, Chemtob S. Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids. J Appl Physiol. 1993;74:1672-8.
9. Segar JL, Merrill DC, Chapleau MW, Robillard JE. Hemodynamic changes during endotracheal suctioning are mediated by increased autonomic activity. Pediatr Res. 1993;33:649-52.
10. Robillard JE, Guillery EN, Segar JL, Merrill DC, Jose PA. Influence of renal nerves on renal function during development. Pediatr Nephrol. 1993;7:667-71.
11. Segar JL, Merrill DC, Robillard JE. Role of endogenous ANG II on resetting arterial baroreflex during development. Am J Physiol. 1994;266:H52-9.
12. Segar JL, Merrill DC, Smith BA, Robillard JE. Role of sympathetic activity in the generation of heart rate and arterial pressure variability in fetal sheep. Pediatr Res. 1994;35:250-4.
13. Merrill DC, Segar JL, McWeeny OJ, Smith BA, Robillard JE. Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development. Am J Physiol. 1994; 267:H1467-75.
14. Guillery EN, Segar JL, Merrill DC, Nakamura KT, Jose PA, Robillard JE. Ontogenic changes in renal response to alpha 1-adrenoceptor stimulation in sheep. Am J Physiol. 1994;267:R990-8.
15. Segar JL, Mazursky JE, Robillard JE. Changes in ovine renal sympathetic nerve activity and baroreflex function at birth. Am J Physiol. 1994;267:H1824-32.
16. Robillard JE, Schutte BC, Page WV, Fedderson JA, Porter CC, Segar JL. Ontogenic changes and regulation of renal angiotensin II type 1 receptor gene expression during fetal and newborn life. Pediatr Res. 1994;36:755-62.
17. Merrill DC, McWeeny OJ, Segar JL, Robillard JE. Impairment of cardiopulmonary baroreflexes during the newborn period. Am J Physiol. 1995;268:H1343-51.
18. Segar JL, Bedell K, Page WV, Mazursky JE, Nuyt AM, Robillard JE. Effect of cortisol on gene expression of the renin-angiotensin system in fetal sheep. Pediatr Res. 1995;37:741-6.
19. Robillard JE, Page WV, Mathews MS, Schutte BC, Nuyt AM, Segar JL. Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. Pediatr Res. 1995;38:896-904.
20. Mazursky JE, Segar JL, Nuyt AM, Smith BA, Robillard JE. Regulation of renal sympathetic nerve activity at birth. Am J Physiol. 1996;270:R86-93.
21. Nuyt AM, Segar JL, Holley AT, O'Mara MS, Chapleau MW, Robillard JE. Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep. Am J Physiol. 1996;271:R1643-53.
22. Segar JL, Chemtob S, Bell EF. Changes in body water compartments with diuretic therapy in infants with chronic lung disease. Early Hum Dev. 1997;25;48:99-107.
23. Segar JL, Minnick A, Nuyt AM, Robillard JE. Role of endogenous ANG II and AT1 receptors in regulating arterial baroreflex responses in newborn lambs. Am J Physiol. 1997;272:R1862-73.
24. Segar JL. Ontogeny of the arterial and cardiopulmonary baroreflex during fetal and postnatal life. Am J Physiol. 1997;273:R457-71.
25. Segar JL, Scholz TD, Bedell KA, Smith OM, Huss DJ, Guillery EN. Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep. Am J Physiol. 1997;273:R1501-8.
26. Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE. Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. Am J Physiol. 1998;274:R160-7.
27. George TN, Johnson KJ, Bates JN, Segar JL. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr. 1998;132:731-4.
28. Samyn ME, Petershack JA, Bedell KA, Mathews MS, Segar JL. Ontogeny and regulation of cardiac angiotensin types 1 and 2 receptors during fetal life in sheep. Pediatr Res. 1998;44:323-9.
29. Mazursky JE, Birkett CL, Bedell KA, Ben-Haim SA, Segar JL. Development of baroreflex influences on heart rate variability in preterm infants. Early Hum Dev. 1998;53:37-52.
30. George TN, Segar JL. Reply. J Pediatr. 1999;134:383-4.
31. Segar JL, Smith OJ, Holley AT. Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep. Am J Physiol. 1999;276:R1295-301
32. Merrill DC, Segar JL, McWeeny OJ, Robillard JE. Sympathetic responses to cardiopulmonary vagal afferent stimulation during development. Am J Physiol. 1999;277:H1311-6.
33. Rupert BE, Segar JL, Schutte BC, Scholz TD. Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles. J Mol Cell Cardiol. 2000;32:2287-97.
34. Nuyt AM, Segar JL, Holley AT, Robillard JE. Autonomic adjustments to severe hypotension in fetal and neonatal sheep. Pediatr Res. 2001;49:56-62.
35. Segar JL, Bedell KA, Smith OJ. Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II. Am J Physiol. 2001;280:R646-54.
36. Segar JL, Barna TJ, Acarregui MJ, Lamb FS. Responses of fetal ovine systemic and umbilical arteries to angiotensin II. Pediatr Res. 2001;49:826-33.
37. Segar JL, Dalshaug GB, Bedell KA, Smith OM, Scholz TD. Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep. Am J Physiol. 2001;281:R2037-47.
38. Dalshaug GB, Scholz TD, Smith OM, Bedell KA, Caldarone CA, Segar JL. Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts. Am J Physiol. 2002;282:H1359-69.
39. Ellsbury DL, Klein JM, Segar JL. Optimization of high-frequency oscillatory ventilation for the treatment of experimental pneumothorax. Crit Care Med. 2002;30:1131-5.
40. Nau PN, Van Natta T, Ralphe JC, Teneyck CJ, Bedell KA, Caldarone CA, Segar JL, Scholz TD. Metabolic adaptation of the fetal and postnatal ovine heart: regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1. Pediatr Res. 2002;52:269-78.
41. Segar JL, Van Natta T, Smith OJ. Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth. Am J Physiol. 2002;283:R460-7.
42. Segar JL, Ellsbury DL, Smith OM. Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus. Am J Physiol. 2002;283:R1395-403.
43. Hammel JM, Caldarone CA, Van Natta TL, Wang LX, Welke KF, Li W, Niles S, Barner E, Scholz TD, Behrendt DM, Segar JL. Myocardial apoptosis after cardioplegic arrest in the neonatal lamb. J Thorac Cardiovasc Surg. 2003;125:1268-75.
44. Roghair RD, Lamb FS, Bedell KA, Smith OM, Scholz TD, Segar JL. Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep. Am J Physiol. 2004;286:R80-8.
45. Karimi M, Wang LX, Hammel JM, Mascio CE, Abdulhamid M, Barner EW, Scholz TD, Segar JL, Li WG, Niles SD, Caldarone CA. Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs. J Thorac Cardiovasc Surg. 2004;127:490-7.
46. Ralphe JC, Segar JL, Schutte BC, Scholz TD. Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. J Mol Cell Cardiol 2004;37:33-41.
47. Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, Segar JL, Du C, Scholz TD. Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. Ann Thorac Surg. 2004;78:948-55.
48. Van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD, Segar JL. Ontogeny of vascular growth factors in perinatal sheep myocardium. J Soc Gynecol Investig. 2004;11:503-10.
49. Lumbers ER, Boyce AC, Joulianos G, Kumarasamy V, Barner E, Segar JL, Burrell JH. Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep. Am J Physiol 2005;288:R567-74.
50. Roghair RD, Lamb FS, Miller FJ Jr., Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol 2005;288:R46-53,.
51. Ralphe JC, Nau PN, Mascio CE, Segar JL, Scholz TD. Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs. Pediatr Res 2005;58:713-718.
52. Mascio CE, Olson AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL. Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. Am J Physiol 2005; 289:R1736-45.
53. Roghair RD, Segar JL, Sharma RV, Zimmerman MC, Jagadeesha DK, Segar EM, Scholz TD, Lamb FS. Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension. Am J Physiol 2005; 289:R1169-R1176.
54. Olson AK, Protheroe KN, Scholz TD, Segar JL. The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. J Soc Gynecol Invest 2006;13:157-65.
55. Olson AK, Protheroe KN, Segar JL, Scholz TD. Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. Am J Physiol Heart Circ Physiol 2006;90:H1587-95
56. Segar JL, Roghair RD, Segar EM, Scholz TD, Lamb FS. Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs prior to hypertension. Am J Physiol Regul Integr Comp Physiol 2006; 291:R481-8.
57. Friese KJ, Widness JA, Segar JL, Schmidt RL, Veng-Pederson P. Increased erythropoietin elimination in fetal sheep following chronic phlebotomy. Pharm Res. 2007; 24:1653-1659
58. Roghair RD, Segar JL, Kilpatrick RA, Segar EM, Scholz TD, Lamb FS. Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone. J Matern Fetal Neonatal Med 2007;20:833-41
59. Olson AK, Protheroe KN, Scholz TD, Segar JL. Activation of the Mitogen-Activated Protein Kinases and Akt in Response to Pulmonary Artery Banding in the Fetal Sheep Heart is Developmentally Regulated. Neonatology 2007;93:145-152.
60. Roghair RD, Miller FJ, Scholz TD, Lamb FS, Segar JL. Endothelial Superoxide Production is Decreased in Sheep Programmed by Early Gestation Dexamethasone Exposure. Neonatology, 2008;93:19-27
61. Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL. Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. Pediatr Res 2008;63:370-374.
62. Von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD. Fetal Programming alters reactive oxygen species production in sheep cardiac mitochondria. Clin Sci (Lond) 2008 Nov 25. [Epub ahead of print].
63. Roghair RD, Segar JL, Volk KA, Chapleau MW, Dallas LM, Sorenson AR, Scholz TD, Lamb FS. Vascular Nitric Oxide and Superoxide Anion Contribute to Sex-Specific Cardiovascular Physiology in Mice. Am J Physiol Regul Integr Comp Physiol. 2009;296:R651-62
64. Segar EM, Norris AW, Yao J-R, Hu S, Koppenhafer SL, Roghair RD, Segar JL, Scholz TD. Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. Clin Sci (Lond). 2009;117:129-38.
65. Reinking BE, Wedemeyer EW, Weiss RM, Segar JL, Scholz TD. Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways. Cardiovasc Diabetol. 2009;8:43.
66. Volk KA, Roghair RD, Jung F, Scholz TD, Lamb FS, Segar JL. Coronary endothelial function and vascular smooth muscle proliferation are programmed by eary-gestation dexamethasone exposure in sheep. Am J Physiol Regul Integr Comp Physiol 2010; 298:R1607-14.
67. Yao J, Wang C, Walsh SA, Hu S, Sawatzke AB, Dang D, Segar JL, Ponto LL, Sunderland JJ, Norris AW. Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography. PLoS One 2010; 5:e12017.
68. Norris AW, Wang C, Yao J, Walsh SA, Sawatzke AB, Hu S, Sunderland JJ, Segar JL, Ponto LL. Effect of insulin and dexamethasone on fetal assimilation of maternal glucose. Endocrinology 2011; 152:255-62.
69. Jonker SS, Scholz TD, Segar JL. The effect of adrenalectomy on the cardiac response to subacute fetal anemia. Can J Physiol Pharm 2011;89: 79-88
70. Jonker SS, Scholz TD, Segar JL. Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep following chronic anemia. Pediatr Res. 2011;69:485-490.
71. Agoudemos M, Reinking BE, Koppenhafer SL, Segar JL, Scholz TD. Programming of adult cardiovascular disease following exposure to late-gestation hyperglycemia. Neonatology 2011; 100:198-205.
72. Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL. Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin Sci (Lond). 2011; 121:427-436.
73. Zinkhan EK, Fu Q, Wan Y, Yu X, Callaway CW, Segar JL. Scholz TD, McKnight RA, Joss-Moore L, Lane RH. Maternal hyperglycemia disrupts histone 3 lysine 36 trimethylation of the IGF-1 gene. J Nutr Metab 2012:930364.
74. Kakhuda R, Peterson ES, Roghair RD, Norris AW, Scholz TD, Segar JL. Sex-specific programming of hypertension in offspring of late gestation diabetic rats. Pediatr Res 2012; 72:352-361.
75. Roghair RD, Volk KA, Lamb FS, Segar JL. Impact of maternal dexamethasone on coronary PGE2 production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Comp Physiol 2012: 303:R513-519.
76. Segar JL, Volk KA, Lipman MH, Scholz TD. Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart. Exp Physiol. 2013; 98:722-33.
77. Hanna MH, Segar JL, Teesch LM, Kasper DC, Schaefer FS, Brophy PD. Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats. Pediatr Res. 2013; 73:585-91.
78. Guo JJ, Stoltz DA, Zhu V, Volk, KA, Segar JL, McCray PB Jr, Roghair RD. Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets. J Cyst Fibros 2014 ; 13 :251-259.
79. Norris AW, Bahr TM, Scholz TD, Peterson ES, Volk KA, Segar JL. Angiotensin II induced cardiovascular load regulates cardiac remodeling and related gene expression in late gestation fetal sheep. Pediatr Res. 2014;75:689-96.
80. Baack ML, Wang C, Hu S, Segar JL, Norris AW. Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis. Reprod Toxicol. 2014;46:129-36.
81. Brophy PD, Shoham DA, Charlton JR, Carmody JB, Reidy KJ, Harshman L, Segar J, Askenazi D. Early-life Course Socioeconomic Factors and Chronic Kidney Disease. Adv Chronic Kid Dis. 2015; 22:16-23.
82. Sandgren J, Scholz TD, Segar JL. ANG II modulation of cardiac growth and remodeling in the immature fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2015; 308:R965-972.
83. Gorden EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, Wang C, Segar JL, Norris AW. Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. J Diabetes Res. 2015; 2015:479565. doi: 10.1155/2015/479565. Epub 2015 May 7.
84. Peotta V, Rahmouni K, Segar JL, Morgan DA, Pitz KM, Rice OM, Roghair RD. Neonatal growth restriction-related leptin deficiency enhances leptin-triggered sympathetic activation and central angiotensin II receptor-dependent stress-evoked hypertension. Pediatr Res. 2016; 80:244-251.
85. Zywicki M, Blohowiak SE, Magness RR, Segar JL, Kling PJ. Increasing fetal ovine number per gestation alters fetal plasma clinical chemistry values. Physiol Rep. 2016 Aug;4(16). pii: e12905. doi: 10.14814/phy2.12905.
86. Kranch-Shorthouse RA, Bauer AS, Magness RR, Lopez GE, Segar JL, Blohowiak SE, Kling PJ. Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys. Biol Reprod. 2017; 96:211-220.
87. Zywicki ME, Blohowiak SE, Magness RR, Segar JL, Kling PJ. Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes. J Vet Diagn Invest. 2018; 30:238-244.
88. Segar DE, Segar EK, Harshman LA, Dagle JM, Carlson SJ, Segar JL. Physiological approach to sodium supplementation in preterm infants. Am J Perinatol. 2018;35(:994-1000.
89. Michel, MC, Colaizy TT, Klein JM, Segar JL, Bell EF. Causes and circumstances of death in a neonatal unit over 20 years. Pediatr Res. 2018; 83:829-833.
90. Kua KL, Hu S, Wang C, Yao J, Dang D, Sawatzke AB, Segar JL, Wang K, Norris AW. Fetal hyperglycemia acutely induces persistent insulin resistance in skeletal muscle. J Endocrinol. 2018 Nov 1. pii: JOE-18-0455.R2.
91. Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA; ROSTERS Study Group. Effects on Resident Work Hours, Sleep Duration and Work Experience in a Randomized Order Safety Trial Evaluating Resident-physician Schedules (ROSTERS). Sleep. 2019 May 20. pii: zsz110. doi: 10.1093/sleep/zsz110.
92. Crockett SL, Harris M, Boatwright N, Su RL, Yarboro MT, Berger CD, Shelton EL, Reese J, Segar JL. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. doi: 10.1038/s41390-019-0716.
93. Segar JL, Grobe CC, Grobe JL. Fetal storage of osmotically inactive sodium. Am J Physiol Regul Integr Comp Physiol. 2020;318:R512-R514.
94. Segar JL. Rethinking furosemide use for infants with bronchopulmonary dysplasia. Pediatr Pulmonol. 2020;55:1100-1103.
95. Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ. Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. Nutrients. 2020 Mar 26;12(4). pii: E900.
 
Books, Chapters, and Reviews
1. Smith FG, Nakamura KT, Segar JL, Robillard JE. Renal function in utero. In: Polin RA and Fox W, eds. Fetal and Neonatal Physiology: W.B. Saunders, Philadelphia, 1991; 115:1187-95.
2. Robillard JE, Segar JL, Smith FG, Jose PA. Regulation of sodium metabolism and extracellular fluid volume during development. Clin Perinatol. 1992; 19:15-31.
3. Robillard JE, Smith FG, Segar JL, Guillery EN, Jose PA. Renal function in the fetus. In: Thorburn GD and Harding R, eds. Textbook of Fetal Physiology. 1994; 196-204.
4. Segar JL, Mazursky JE, Merrill DC. Neural regulation of blood pressure during fetal and newborn life. In: Polin RA and Fox W, eds. Fetal and Neonatal Physiology: W.B. Saunders, Philadelphia, 1997; 2nd edition, 1665-1676.
5. Segar JL. Neural regulation of blood pressure during fetal and newborn life. In: Polin RA, Fox WW, Abman SH (eds): Fetal and Neonatal Physiology, Third Edition, Philadelphia, W.B. Saunders, 2004.
6. SegarJL, Robillard JE. Neurohumoral regulation of blood pressure during early development. In Portman RJ, Sorof JM, Ingelfinger JR (eds): Pediatric Hypertension. Towata NJ. Humana Press Inc., 2004.
7. SegarJL Neurohumoral regulation of blood pressure in early development. In Portman RJ, Sorof JM, Ingelfinger JR (eds): Pediatric Hypertension. Towata NJ. Humana Press Inc., 2010. Second edition.
8. Segar JL. Autonomic and Cental Regulation of Fetal Cardiovascular Function. In: Polin RA, Fox WW, Abman SH (eds): Fetal and Neonatal Physiology, Fourth Edition, Philadelphia, W.B. Saunders, 2011
9. Segar JL. Neonatal Diuretic Therapy: Furosemide, Thiazides and Spironolactone. Clinics in Perinatology, 2012; 39:209-220
10. Segar JL. Neurohumoral and Autonomic Regulation of Blood Pressure. In Flynn JT, Portman RJ, Ingelfinger JR (eds): Pediatric Hypertension (3rd Edition), New York, NY. Humana Press, 2013
11. Bell, EB, Segar JL, Oh W. Fluid and Electrolyte Management. In MacDonald MG, Seshia MHK, Mullett MD (eds): Avery’s Neonatology: Pathophysiology & Management of the Newborn, seventh edition, Philadelphia, PA. Lippincott Williams & Wilkins, 2015
12. Segar JL, Giussani DA. Neural Regulation of Blood Pressure During Fetal and Newborn Life. In: Polin RA, Abman SH, Benitz W, Rowitch D (eds): Fetal and Neonatal Physiology, Fifth Edition, Amsterdam, Elsevier 2016
13. Segar JL, Bell EF, Johnson LH, Bhutani VK. Vitamin E Metabolism in the Fetus and Newborn Infant. In: Polin RA, Abman SH, Benitz W, Rowitch D (eds): Fetal and Neonatal Physiology, Fifth Edition, Amsterdam, Elsevier 2016
14. Brophy PD, Charlton JR, Carmody JB, Reidy KJ, Harshman L, Segar J, Askenazi D, Shoham D, Bagby SP. Chronic Kidney Disease: A Life Course Health Development Perspective. In: Halfon N., Forrest C., Lerner R., Faustman E. (eds) Handbook of Life Course Health Development. Springer, Cham. 2018
15. Segar JL. Fluid and Electrolyte Management of High Risk Infants. In: Oh W, Guignard J, Baumgart S (eds): Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and Controversies. Third Edition. 2018
16. Segar JL. Neurohumoral and Autonomic Regulation of Blood Pressure. In: Flynn JT, Ingelfinger JR, Redwine (eds): Pediatric Hypertension (4th Edition), Springer International Publishing AG, 2018
17. Lane RH, Majnik AV, Segar JL. Race in the social-epigenomic regulation of pre- and perinatal development. In: Ferguson BS (ed): Nutritional Epigenomics, London, Elsevier 2019
 
Editorials, Letters to Editor, Other
1. Segar J, Brophy P. Maintenance Intravenous Fluids. Pediatrics. 2019;143:e21090030
2. Segar JL. AAP recommends isotonic maintenance intravenous fluid. J Pediatr. 2019; 208:294-295
 
Abstracts
1. Segar JL, Rivera A Jr, Wagener JS. Effect of long-term steroid administration on lung growth in newborn rabbits. Pediatr Res. 1989; 25:326A.
2. *Segar JL, Smith BA, Smith FG, Jose PA, Robillard JE. Effects of dopamine-1 (DA-1) receptor activation on renal function during fetal life. Pediatr Res. 1990; 27:64A
3. Segar JL, Hajduczok G, Smith FG, Robillard JE. Effects of arterial pressure changes on arterial baroreflex resetting during development. Pediatr Res. 1991; 29:247A.
4. *Segar JL, Smith BA, Smith FG, Jose PA, Robillard JE. Role of endogenous dopamine (DA) and dopamine-1 (DA-1) receptors in control of arterial pressure and renal function during development. Pediatr Res. 1991; 29:65A.
5. *Chemtob S, Segar JL, Johnson K, Bell EF, Robillard JE. Avoidance of pharmacologic tolerance to furosemide (furo) by combined diuretic therapy with metolazone (met). Pediatr Res. 1991; 29:208A.
6. *Segar JL, Hajduczok G, Smith BA, Robillard JE. Changes in the arterial baroreflex response during development. Clin Res. 1991; 39:687A.
7. *Segar JL, Merrill DC, Robillard JE. Increased sympathetic outflow mediates hemodynamic changes during endotracheal suctioning. Pediatr Res. 1992; 31:222A.
8. *Malcolm DD, Segar JL, Barna T, Robillard JE, Chemtob S. Indomethacin further compromises the depressed cardiovascular function induced by positive pressure ventilation (PPV) in the newborn pig: The hemodynamic effects of indomethacin (INDO) and of PPV are independent of prostanoids (PG-TX). Pediatr Res. 1992; 31:236A.
9. *Merrill DC, Segar JL, Smith BA, Robillard JE. Cardiopulmonary receptor modulation of arterial baroreceptor function during development. Pediatr Res. 1992; 31:236A.
10. *Segar JL, Hajduczok G, Smith BA, Robillard JE. Baroreflex control of sympathetic outflow during development: Influence of maturational changes in blood pressure. Pediatr Res. 1992; 31:238A.
11. *Segar JL, Merrill DC, Smith BA, Robillard JE. Role of Angiotensin II (AII) on baroreflex control of sympathetic outflow in fetal (F) and newborn (NB) sheep. Pediatr Res. 1992; 31:239A.
12. *Robillard JE, Page WV, Smith FG, Segar JL, Perlman S. Renal nerves increase renin gene expression and renin secretion at birth. Pediatr Res. 1992; 31:341A.
13. *Segar JL, Merrill DC, Smith BA, Robillard JE. Role of sympathetic outflow in the generation of heart rate and arterial pressure variability in fetal sheep. Pediatr Res. 1993; 33:235A.
14. *Segar JL, Mazursky JE, Smith BA, Merrill DC, Robillard JE. Changes in baroreflex control of sympathetic activity at the time of birth. Pediatr Res. 1993; 33:251A.
15. *Segar JL, Merrill DC, Smith BA, Robillard JE. Role of central angiotensin II in modulating baroreflex responses after birth in newborn sheep. Pediatr Res. 1993; 33:252A.
16. *Mazursky JE, Segar JL, Smith BA, Merrill DC, Robillard JE. Rapid increase in renal sympathetic nerve activity (RSNA) during the transition from fetal to newborn life. Pediatr Res. 1993; 33:361A.
17. Merrill DC, Robillard JE, Weiner CP, Segar JL. Gestational-age dependent maturation of autonomic reflexes in the human fetus. Pediatr Res. 1993; 33:249A.
18. *Mazursky JE, Robillard JE, Segar JL. Mechanisms regulating renal sympathetic nerve activity (RSNA) during the transition from fetal to newborn life. Clin Res. 1993; 41:625A
19. *Mazursky JE, Robillard JE, Segar JL. Mechanisms regulating renal sympathetic nerve activity (RSNA) during the transition from fetal to newborn life. Pediatr Res. 1994; 35:240A.
20. *Segar JL, Bedell K, Page WV, Robillard JE. Effect of glucocorticoids on renin-angiotensin system gene expression during fetal life. Pediatr Res. 1994; 35:77A.
21. *Segar JL, Smith BA, Minnick A, Robillard JE. Role of central angiotensin II type 1 receptors (AT1) in modulating baroreflex responses during postnatal life. Pediatr Res. 1994; 35:41A.
22. *Robillard JE, Schutte BC, Porter CC, Page WV, Segar JL. Ontogenic changes and regulation of renal angiotensin II type 1 (AT1) receptor gene during fetal and postnatal life. Pediatr Res. 1994; 35:75A.
23. *Nuyt AM, Segar JL, Mazursky JE, Robillard JE. Baroreflex modulation of sympathetic outflow by vasopressin (AVP) during fetal and postnatal life. Pediatr Res. 1994; 35:39A.
24. *Merrill DC, McWeeny OJ, Segar JL, Robillard JE. Ontogeny of cardiopulmonary reflex control of renal sympathetic nerve activity (RSNA). Pediatr Res. 1994; 35:369A.
25. *Nuyt AM, Segar JL, Mazursky JE, Merrill DC, Robillard JE. Differential sympathetic responses induced by sodium chloride during fetal and postnatal life. Pediatr Res. 1994; 35:244A.
26. *Robillard JE, Page WV, Mathews MS, Nuyt AM, Segar JL. Effect of angiotensin II on renal angiotensin II type 1 (AT1) and type 2 (AT2) receptor mRNA expression in late gestation fetal sheep. Pediatr Res. 1995; 37:368A.
27. *Segar JL, Bedell KA, Fouron JC, Chemtob S. Effect of pulmonary artery banding on angiotensin type 1 (AT1) receptor regulation in fetal sheep. Pediatr Res. 1995; 37:34A.
28. *Segar JL, Minnick A, Nuyt AM, Robillard JE. Developmental changes in central vasopressin regulation of cardiovascular function. Pediatr Res. 1995; 37:34A.
29. *Mazursky JE, Birkett CL, Segar JL. Assessment of baroreflex control of heart rate variability in preterm infants. Pediatr Res. 1995; 37:223A.
30. *Segar JL, Page WV, Mathews MS, Merrill DC, Robillard JE. Differential tissular regulation of angiotensin II type 1 (AT1) receptor mRNA expression by angiotensin II (AII) during fetal life. Pediatr Res. 1995; 37:69A.
31. *Segar JL, Bedell KA, Sharma RV. Regulation of angiotensin (AII) mediated autonomic responses during development. J Invest Med. 1995; 43:420A.
32. *AM Nuyt, Merrill DC, Segar JL, Chapleau MW, Robillard JE. Autonomic adjustments to severe hypotension during fetal and postnatal life: ontogeny of the Bezold-Jarisch reflex. Pediatr Res. 1996; 39:33A.
33. *Segar JL, Bedell KA, Mathews MS, Petershack JA, Robillard JE. Ontogeny and regulation of cardiac angiotensin II receptor subtypes (AT1 and AT2) in developing sheep. Pediatr Res. 1996; 39: 37A.
34. Segar JL, Bedell KA, Sharma RV. Regulation of angiotensin II (AII) mediated autonomic responses during development. Pediatr Res. 1996; 39: 68A
35. *AM Nuyt, Holley AT, Chemtob S, Chapleau MW, Segar JL, Robillard JE. Role of endogenous prostaglandins in the regulation of arterial baroreceptor activity during development. Pediatr Res. 1996; 39: 234A.
36. *Segar JL, Lumbers ER, Smith OM, Robillard JE. Corticosteroids increase the sympathetic response at birth in premature fetal sheep. Pediatr Res. 1996; 39: 244A.
37. *Petershack JA, Page WV, Mathews MS, McWeeny OJ, Segar JL, Robillard JE. Tissue-specific and differential regulation of AT1 and AT2 gene expression following administration of an AT1 antagonist during fetal life. Pediatr Res. 1996; 39: 367A.
38. *George TN, Johnson KJ, James TL, Segar JL. Effect of inhaled nitric oxide on bleeding time and platelet aggregation in neonates. J Invest Med. 1996; 44: 340A.
39. *Guerguerian A-M, Hardy P, Lahaie I, Bhattacharya M, Peri K, Segar J, Olley P, Fouron J-C, St. Louis J, Varma DR, Chemtob S. Cycloxygenase (COX)-2 is the main intrinsic source of prostaglandins (PG) in the ductus arteriosus (DA) of the newborn (NB) but not the fetus. Pediatr Res. 1997; 41: 21A.
40. *Samyn M, Petershack J, Mathews MS, Segar JL, Robillard JE. Effects of losartan on angiotensin receptors during fetal cardiac development in sheep. Pediatr Res. 1997; 41: 25A.
41. *Petershack JA, Samyn ME, Segar JL, Robillard JE. Influence of AT1 receptor activity on AT1 and AT2 receptor expression during fetal life. Pediatr Res. 1997; 41: 50A.
42. George TN, Johnson KJ, Bates JN, Segar JL. The effect of inhaled nitric oxide (NO) on bleeding time and platelet aggregation in neonates. Pediatr Res. 1997; 41: 150A.
43. *Segar JL, Smith OJ, Bedell KA. Cardiac hypertrophy is not attenuated by angiotensin type 2 (AT2) receptor blockade in fetal sheep. Pediatr Res. 1998; 43: 26A.
44. Segar JL, Bedell KA, Ramirez C, Acarregui MJ. Angiotensin II type 1 (AT1) receptor expression and regulation in human fetal lung in vitro. Pediatr Res. 1998; 43:54A.
45. *Segar JL, Smith OJ, Holley AT. Mechano- and chemoreceptor modulation of renal sympathetic nerve activity (RSNA) at birth in term lambs. Pediatr Res. 1998; 43:193A.
46. *Segar JL, Barna TJ, Acarregui MJ, Lamb FS. The angiotensin AT1 receptor mediates vasoconstriction in fetal umbilical and systemic arteries. Pediatr Res. 1999; 45:62A.
47. *Segar JL, Smith OJ, Bedell KA. Effects of antenatal glucocorticoids on cardiovascular and autonomic function in preterm lambs are not mediated by the renin-angiotensin system. Pediatr Res. 1999; 45:223A.
48. *Dalshaug GB, Scholz TD, Caldarone CA, Segar JL. Adaptive responses of the coronary vasculature to acute right ventricle pressure overload in fetal sheep. Pediatr Res 47: 2000; 41A.
49. *Segar JL, Smith OJ, Bedell KA, Scholz TD. Angiotensin II induced growth responses in the fetal sheep heart. Pediatr Res 47: 2000; 50A.
50. *Ellsbury DL, Smith OJ, Segar JL. Ablation of the paraventricular nucleus attenuates sympathoexcitation at birth. Pediatr Res 47: 2000; 397A.
51. *Ellsbury DL, Smith OJ, Klein NJ, Segar JL. Treatment of pneumothorax with high frequency oscillatory ventilation (HFOV): effect of ventilator frequency on gas flow through the chest tube. Pediatr Res 49: 2001, 45A.
52. *Raphe JC, Segar JL Schutte BT, Scholz TD. Characterization of the aspartate-glutamate carrier in cardiac mitochondria. J Invest Med 49:273A 2001; Pediatr Cardiol 22:443, 2001.
53. Van Natta TL, Caldarone CA, Scholz TD, Segar JL. Perinatal changes in cardiac metabolism in sheep: Roles of hypoxia-inducible factor 1 and nuclear respiratory factor 1. J Invest Med 2001; 49: 271A.
54. *Hammel JM, Van Natta TL, Wang LX, Welke KF, Barner EW, Acarregui MJ, Scholz TD, Segar JL, Caldarone CA. Cardioplegic arrest causes greater myocardial apoptosis in neonatal than mature lambs. Circulation 2002;106: II-658.
55. *Ralphe JC, Schutte BC, Segar JL, Scholz TD. Identification and localization of brain excitatory amino acid transporters in heart. Circulation 2003; 106: II-92.
56. *Roghair RD, Lamb FS, Scholz TD, Segar JL. Antenatal betamethasone-induced alterations in coronary vascular reactivity. J Invest Med 2002; 50: 211A.
57. *Wang LX, Karimi M, Hammel JM, Barner EW, Li WG, Scholz TD, Segar JL, Weintraub NL, Caldarone CA. Mechanism of activation of myocardial apoptosis in the post-cardioplegic neonatal lamb heart. J Am Coll Cardiol 2003; 41: 495A.
58. *Ralphe JC, Segar JL, Schutte BC, Scholz TD. Cardiac mitochondrial localization of the brain excitatory amino acid transporter 1. Pediatr Res 2003; 53: 37A.
59. *Roghair RD, Lamb FS, Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced coronary and mesenteric artery vascular reactivity. Pediatr Res 2003; 53: 55A.
60. *Mascio CE, Van Natta T, Ralphe JC, Nau PN, Segar JL, Scholz TD. Regulation of myocardial expression of vasculogenic factors and glycolytic enzymes in the anemic ovein fetus. Pediatr Res 2003; 53: 344A.
61. *Ralphe JC, Nau PN, Mascio CE, Van Natta T, Segar JL, Scholz TD. Myocardial glucose transporters, GLUT1 and GLUT4, in the chronically anemic fetal heart. Pediatr Res 2003; 53: 344A.
62. *Roghair RD, Lamb FS, Scholz TD, Segar JL. Antenatal betamethasone augments coronary contraction to angiotensin II and upregulates AT1 receptor protein. Pediatr Res 2003;53: 417A.
63. *Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar, JL. Programming of coronary artery dysfunction by early gestation dexamethasone exposure. Pediatr Res 2003; 54(5):773.
64. *Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar, JL. Early gestation glucocorticoid exposure enhances postnatal coronary artery vasoconstriction. Pediatr Res 2004; 55(4):96A.
65. *Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar, JL. Coronary artery NAD(P)H oxide expression and superoxide anion production is enhanced by early gestation glucocorticoid exposure. Pediatr Res 2004; 55(4):178A.
66. *Olson AK, Scholz TD, Segar JL. Differential Regulation of the Mitogen-Activated Kinases in the Fetal Sheep Heart in response to chronic anemia. Pediatr Res 2004; 55:37A
67. *Olson AK, Scholz TD, Segar JL Activation of the Mitogen-Activated Protein Kinases in tehte Pressure-loaded fetal sheep heart. Pediatr Res 2004; 55:37A
68. *Carter JC, Koppenhafer SL, Segar JL, Scholz TD. Brain EAAT1 fundtions in the cardiac mitochondrial malate/aspartate shuttle. Pediatr Res 2004; 55:42A
69. Segar JL, Barner E, Ford SP, Nijland MJ, Nathalnielsz PW, Scholz TD. Effects of maternal undernutrition of mitogen-activated protein kinase expression the fetal heart. Pediatr Res 2004; 55:100A
70. *Segar EM, Roghair RD, Lamb FS, Scholz TD, and Segar, JL. Early gestation dexamethasone exposure alters calcium transients in coronary vascular smooth muscle cells in newborn lambs. Pediatr Res 2004; 56(4):669.
71. *Roghair RD, Bailey MC, Lamb FS, Miller FJ, Scholz TD, and Segar, JL. Early gestation dexamethasone exposure alters coronary artery reactivity in newborn lambs. Pediatr Res 2004; 56(4):669.
72. *Segar JL, Roghair, RD, Scholz TD, Lamb FS. Vascular reactivity is programmed in lambs prior to hypertension. FASEB Journal 2005; 19:A739.
73. *Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar JL. Altered prostaglandin production the fetal programming of ovine coronary artery vascular reactivity. FASEB Journal 2005; 19:A740
74. *Roghair RD, Bailey MC, Lamb FS, Miller, Jr. FJ, Scholz TD, Segar JL. Programmed alterations in newborn lamb coronary artery reactivity. PAS 2005: 57:107
75. *Roghair RD, Segar EM, Lamb FS, Scholz TD, Segar JL. Postnatal coronary vascular smooth muscle cell calcium transients are altered following early gestation dexamethasone exposure in lambs. PAS 2005: 57:108
76. Widness JA, Belsare GN, Schmidt RL, Zimmerman MB, Segar JL. Phlebotomy acutely increases erythrocyte zinc protoporphyrin (znpp) in fetal sheep. PAS 2005: 57: 1292
77. Ralphe JC, Segar JL, Scholz TD. Thyroid hormone increases eaat1 expression in rat myocardium. PAS 2005: 57:2483
78. *Roghair RD, Lamb FS, Miller FJ, and Segar JL. Early gestation dexamethasone-exposure programs tissue-specific alterations in reactive oxygen species production. Pediatr Res 2005; 58(5):1012.
79. *Roghair RD, Lamb FS, Scholz TD, and Segar JL. Programmed coronary dysfunction: evidence for attenuated vasodilatory prostanoid production. Pediatr Res 2005; 58(5):1047.
80. *Roghair RD, Segar JL, Scholz TD, and Lamb FS. Maternal low protein diet or dexamethasone administration impairs endothelial-dependent reactivity and glucose tolerance in a murine model of fetal programming. FASEB J 2006; 20(4):A758.
81. *Baserga MC, Roghair RD, Hale MA, Lamb FS, McKnight RA, Scholz TD, Segar JL, and Lane RH. Prenatal steroid exposure causes similar changes in rat and sheep renal chromatin structure. E-PAS2006:59:2874.312.
82. *Roghair RD, Lamb FS, Miller Jr. FJ, Scholz TD, and Segar JL. Coronary reactivity to angiotensin II is enhanced by endothelial superoxide production in an ovine model of fetal programming. E-PAS2006:59:3718.3.
83. *Roghair RD, Segar JL, Scholz TD, and Lamb FS. Impaired coronary EDHF production in programmed newborn sheep. Early Human Development 2006; 82(8):519
84. *Roghair RD, Lamb FS, Scholz TD, and Segar JL. Naturally occurring perinatal growth restriction programs blood pressure in adult mice. Early Human Development 2006; 82(8):521.
85. *Roghair RD, Lamb FS, Miller Jr. FJ, and Segar JL. Endothelial superoxide production is decreased in sheep programmed by early gestation dexamethasone exposure. E-PAS2007:61:6298.2.
86. *Roghair RD, Segar JL, Scholz TD, and Lamb FS. Newborn sheep programmed by early gestation dexamethasone have increased coronary reactivity due to impaired endothelial-derived hyperpolarizing factor production. E-PAS2007:61:6298.3.
87. Roghair RD, Lamb FS, Spector AA, and Segar JL. Impaired cyclooxygenase-dependent dilation and prostaglandin E2 production contribute to programmed coronary artery dysfunction in adolescent sheep. E-PAS2007:61:7710.1.
88. *Roghair RD, Segar JL, Scholz TD, and Lamb FS. Early gestation dexamethasone exposure programs mesenteric artery serotonin responsiveness. E-PAS2007:61:6298.4.
89. Roghair RD, Reinking BE, Segar JL, and Scholz TD. Renal hyperfiltration and increased sympathetic drive contribute to murine perinatal growth restriction-induced hypertension. E-PAS2007:61:5550.3.
90. Norris AW, Yao J, Hu S, Koppenhafer SL, Segar JL, and Scholz TD. A model of fetal diabetic programming with increased birthweight variance. E-PAS2007:61:5879.12.
91. Von Bergen NH, Koppenhafer SL, Volk K, Roghair RD, Segar JL, Lamb FS, and Scholz TD. Cardiac mitochondrial reactive oxygen species production is enhanced in female sheep programmed by intrauterine dexamethasone. E-PAS2008:63:4045.8.
92. *Volk K, Barna T, Goss K, Bedell K, Scholz T, Segar J, and Lamb F. Enhanced proliferation of coronary artery cells is programmed by fetal steroid exposure. E-PAS2008:63:4045.9.
93. *Segar EM, Roghair RD, Scholz TD and Segar JL. Reactive oxygen species (ROS) mediate altered vascular reactivity in adult offspring of rats with gestational diabetes. E-PAS2008:63:5816.1.
94. Zinkhan E, Fu Q, Hale M, Wang Y, Scholz T, Segar J, Joss-Moore L, Lane R. Diabetes Mellitus Alters the Hepatic Histone Code along the Rat IGF-1 Gene. E-PAS 2009:5501.9
95. *Roghair R, Wemmie J, Volk K, Scholz T, Lamb F, Segar J. Maternal Antioxidant Blocks Glucocorticoid-Programmed Hemodynamic and Behavioral Phenotypes in Mice. E-PAS 2010: 1340.6.
96. *Segar J, Lipman M, Volk K, Scholz T. Thyroid Hormone Modulates Growth Responses in Pressure-Loaded Ovine Fetal Heart. E-PAS 2010: 2725.7.
97. *Zinkhan E, Fu Q, Hale M, Wang Y, Scholz T, Segar J, Joss-Moore L, Lane R. Maternal Diabetes Alters DNA Methylation of the Hepatic IGF-1 Gene. E-PAS 2010: 4416.464.
98. *Dang D, Wang C, Segar J, Norris A. Uterine Artery Vasorelaxation by Nitric Oxide Rescues Hyperglycemia-Induced Intrauterine Growth Restriction. E-PAS 2011: 1360.5.
99. *Hanna M, Segar J, Teesch L, Brophy P. Metabolomic Markers of Nephrotoxicity in Newborn Rats. E-PAS 2011:1407.75.
100. *Baack M, Koppenhafer S, Yao J, Norris A, Segar J. Hyperglycemia Induced Alterations of Placental Fatty Acid Transport. E-PAS 2011:1414.177.
101. *Katkhuda R, Scholz T, Segar J. Exposure to Hyperglycemia In Utero Results in Hypertension in Adult Male Offspring but Not Females. E-PAS 2011:3607.2.
102. Roghair R, Segar J, Lamb F, Zhu V, Stoltz D, McCray P, Welsh M. Cystic Fibrosis Pigs Have Genotype-Specific Alterations in Aortic Reactivity. E-PAS 2011:4435.5.
 

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