Medical College of Wisconsin
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CURRICULUM VITAE

Jennifer A. Doll PhD
Assistant Professor
Department of Biomedical Sciences

OFFICE ADDRESS:
UWM Dept of Biomedical Sciences
PO Box 413
Milwaukee, WI 53201
Email: dollj@uwm.edu

EDUCATION:
1986 - 1990 B.S., Biology, Rockhurst University, Kansas City, MO
1990 - 1992 M.S., Molecular Biology, Loyola University, Chicago, IL
1992 - 1997 Ph.D., Molecular Genetics, Washington University, St. Louis, MO

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1996 - 2003 Postdoctoral Fellow, Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL

FACULTY APPOINTMENTS:
2003 - 2008 Research Assistant Professor, Hematology/Oncology; Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
2008 - 2010 Research Scientist, Surgery, NorthShore University HealthSystem, Evanston, IL
2010 - 2011 Assistant Professor, Surgery, NorthShore University HealthSystem, affiliate of The University of Chicago, Evanston, IL
2011 - Present Assistant Professor, Biomedical Sciences, University of Wisconsin, Milwaukee, Milwaukee, WI


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. G Iordanescu, CB Brendler, SE Crawford, AM Wyrwicz, PN Venkatasubramanian, JA Doll. MRS Measured Fatty Acid Composition of Periprostatic Adipose Tissue Correlates with Pathological Measures of Prostate Cancer Aggressiveness. J Magnetic Resonance Imaging, 42(3):651-7, 2015. doi: 10.1002/jmri.24824. PMID: 25522916; PMCID: PMC Journal In Process.
2. Venkatasubramanian PN, Brendler CB, Plunkett BA, Crawford SE, Fitchev PS, Morgan G, Cornwell ML, McGuire MS, Wyrwicz AM, Doll JA. Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study. Prostate. 2014 Feb;74(3):326-35.
3. Homan EP, Rauch F, Grafe I, Lietman C, Doll JA, Dawson B, Bertin T, Napierala D, Morello R, Gibbs R, White L, Miki R, Cohn DH, Crawford S, Travers R, Glorieux FH, Lee B. Mutations in SERPINF1 cause osteogenesis imperfecta type VI. J Bone Miner Res. 2011 Dec;26(12):2798-803. PMCID: PMC3214246
4. Yu N, Kozlowski JM, Park II, Chen L, Zhang Q, Xu D, Doll JA, Crawford SE, Brendler CB, Lee C. Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor. Urology. 2010 Dec;76(6):1519.e8-13. PMCID: PMC2997920
5. Fitchev PP, Wcislak SM, Lee C, Bergh A, Brendler CB, Stellmach VM, Crawford SE, Mavroudis CD, Cornwell ML, Doll JA. Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. Lab Invest. 2010 Jul;90(7):1078-90. PMCID: PMC3055786
6. Halin S, Rudolfsson SH, Doll JA, Crawford SE, Wikström P, Bergh A. Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. Neoplasia. 2010 Apr;12(4):336-45. PMCID: PMC2847741
7. Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Gastroenterology. 2009 Jan;136(1):331-340.e2. PMCID: PMC2833423
8. Chung C, Doll JA, Stellmach VM, Gonzales J, Surapureddi S, Cornwell M, Reddy JK, Crawford SE. Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. Adv Exp Med Biol. 2008;617:591-7.
9. Chung C, Doll JA, Gattu AK, Shugrue C, Cornwell M, Fitchev P, Crawford SE. Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J Hepatol. 2008 Mar;48(3):471-8.
10. Plunkett BA, Fitchev P, Doll JA, Gerber SE, Cornwell M, Greenstein EP, Crawford SE. Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths. Reprod Biol. 2008 Jul;8(2):107-20.
11. Hobbs JE, Zakarija A, Cundiff DL, Doll JA, Hymen E, Cornwell M, Crawford SE, Liu N, Signaevsky M, Soff GA. Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. Thromb Res. 2007;120 Suppl 2:S13-21.
12. Browne M, Stellmach V, Cornwell M, Chung C, Doll JA, Lee EJ, Jameson JL, Reynolds M, Superina RA, Abramson LP, Crawford SE. Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model. Pediatr Res. 2006 Sep;60(3):282-7.
13. Wang H, Doll JA, Jiang K, Cundiff DL, Czarnecki JS, Wilson M, Ridge KM, Soff GA. Differential binding of plasminogen, plasmin, and angiostatin4.5 to cell surface beta-actin: implications for cancer-mediated angiogenesis. Cancer Res. 2006 Jul 15;66(14):7211-5.
14. Soff GA, Wang H, Cundiff DL, Jiang K, Martone B, Rademaker AW, Doll JA, Kuzel TM. In vivo generation of angiostatin isoforms by administration of a plasminogen activator and a free sulfhydryl donor: a phase I study of an angiostatic cocktail of tissue plasminogen activator and mesna. Clin Cancer Res. 2005 Sep 01;11(17):6218-25.
15. Doll JA, Soff GA. Angiostatin. Cancer Treat Res. 2005;126:175-204.
16. Halin S, Wikström P, Rudolfsson SH, Stattin P, Doll JA, Crawford SE, Bergh A. Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. Cancer Res. 2004 Aug 15;64(16):5664-71.
17. Ferbend P, Abramson LP, Backer CL, Mavroudis C, Webb CL, Doll JA, Junewick JJ, Crawford SE. Cardiac plasma cell granulomas: response to oral steroid treatment. Pediatr Cardiol. 2004;25(4):406-10.
18. Grayhack JT, Smith ND, Ilio K, Wambi C, Kasjanski R, Crawford SE, Doll JA, Wang Z, Lee C, Kozlowski JM. Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. J Urol. 2004 Jan;171(1):434-8.
19. Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J, Crawford SE. Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med. 2003 Jun;9(6):774-80.
20. Abramson LP, Stellmach V, Doll JA, Cornwell M, Arensman RM, Crawford SE. Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. J Pediatr Surg. 2003 Mar;38(3):336-42; discussion 336-42.
21. Doll JA, Reiher FK, Crawford SE, Pins MR, Campbell SC, Bouck NP. Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate. Prostate. 2001 Dec 01;49(4):293-305.
22. Doll JA, Zhu X, Furman J, Kaleem Z, Torres C, Humphrey PA, Donis-Keller H. Genetic analysis of prostatic atypical adenomatous hyperplasia (adenosis). Am J Pathol. 1999 Sep;155(3):967-71. PMCID: PMC1866890
23. Doll JA, Suarez BK, Donis-Keller H. Association between prostate cancer in black Americans and an allele of the PADPRP pseudogene locus on chromosome 13. Am J Hum Genet. 1996 Feb;58(2):425-8. PMCID: PMC1914538
24. Iordanescu G, Brendler C, Crawford SE, Wyrwicz AM, Venkatasubramanian PN, Doll JA. MRS measured fatty acid composition of periprostatic adipose tissue correlates with pathological measures of prostate cancer aggressiveness. J Magn Reson Imaging. 2015 Sep;42(3):651-7.
25. Gonzalez AB, Young L, Doll JA, Morgan GM, Crawford SE, Plunkett BA. Elevated neonatal insulin-like growth factor I is associated with fetal hypertrophic cardiomyopathy in diabetic women. Am J Obstet Gynecol. 2014 Sep;211(3):290.e1-7.
26. Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L, Pasche B, Lee C, Grippo PJ. TGF-β: duality of function between tumor prevention and carcinogenesis. J Natl Cancer Inst. 2014 Feb;106(2):djt369. PMCID: PMC3952197
 
Books, Chapters, and Reviews
1. Doll JA and GA Soff. “Angiostatin: Generation, Structure and Function of the Isoforms.” In Cytokines and Cancer, pp. 175-204. L.C. Platanias, Ed. Cancer Treat. Res. series. Kluwer Academic Publishers, Norwell, MA, 2005.
2. Doll JA, JE Hobbs and GA Soff. Role of Apoptosis in Anti-angiogenic Cancer Therapies. In Apoptosis and Senescence in Cancer Chemotherapy and Radiotherapy. Humana Press, Inc., Totowa, NJ, 2007.