CURRICULUM VITAE
John A. Corbett PhD
John A. Corbett PhD
Chair, Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Medical Education Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
09/1981 - 05/1985 BS - Chemistry, St. Norbert College, DePere, WI |
09/1985 - 09/1990 PhD - Biochemistry, Utah State University, Logan, UT |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
11/1990 - 1994 Department of Pathology, School of Medicine, Washington University, St. Louis, MO |
2008 School of Medicine, Executive Leadership School, University of Alabama, Birmingham,, AL |
2009 School of Medicine, Healthcare Leadership Academy, University of Alabama, Birmingham, AL |
FACULTY APPOINTMENTS: |
1985 - 1989 Teaching Assistant, Department of Chemistry and Biochemistry, Utah State University, Logan, UT |
1990 Instructor, Department of Chemistry and Biochemistry, Utah State University, Logan, UT |
1994 Instructor in Pathology, Department of Pathology, School of Medicine, Washington University, St. Louis, MO |
1995 Assistant Professor, Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO |
2000 Associate Professor, Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO |
2002 Associate Professor (secondary appointment), Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, St. Louis, MO |
2005 Professor, Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO |
2007 Professor, Departments of Cell Biology, Microbiology and Immunology, and Pathology (secondary appointments), University of Alabama at Birmingham, Birmingham, AL |
2007 - 2009 Director, Department of Medicine, Comprehensive Diabetes Center, University of Alabama, Birmingham, AL |
2007 Professor, Department of Medicine (Primary), Cell Biology, Microbiology and Immunology, and Pathology (secondary appointments), University of Alabama, Birmingham, AL |
2010 - Present Professor and Chairman, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
1981 - 1982 Presidential Scholarship |
1983 - 1984 Scholarship, George F. Schneider |
1989 Biochemistry Award, Greenwood Memorial |
1991 Individual National Research Service Award, NIH |
1991 International Postdoctoral Fellowship, Juvenile Diabetes Foundation |
1994 Plenary Lecture 15th International Diabetes Congress, Kobe, Japan |
1995 International Career Development Award, Juvenile Diabetes Foundation |
1996 Research Scholar, Council for Tobacco Research |
1996 Novo Nordisk Lecture, Australian Diabetes Society |
2000 Scientific Advisory Board, First-Third International Conference: Biology, Chemistry and Therapeutic Applications of Nitric Oxide |
2002 Scientific Advisory Board, First-Third International Conference: Biology, Chemistry and Therapeutic Applications of Nitric Oxide |
2004 Scientific Advisory Board, First-Third International Conference: Biology, Chemistry and Therapeutic Applications of Nitric Oxide |
2007 Student Invite Lecture: Department of Biology, St. Louis University |
2007 - 2009 Endowed Chair in Juvenile Diabetes Research, Nancy R. and Eugene C. Gwaltney Family |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
American Society for Biochemistry and Molecular Biology (Member) |
American Diabetes Association (Member) |
American Chemical Society (Member) |
International Diabetes Federation (Member) |
Nitric Oxide Society (Member) |
Juvenile Diabetes Foundation International (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
2006 Drug Discovery Today: Disease Mechanisms, Metabolic disorders and inflammation. Volume 3, Issue 3 |
01/07/2013 - 06/30/2016 American Journal of Physiology-Regulatory, Intergrative and Comparative Physiology |
Editorial Board |
2001 - Present American Journal of Physiology: Endocrinology and Metabolism |
2005 - 2010 Journal of Biological Chemistry |
2008 - Present Trends Endocrinol. Med. |
2008 - Present Diabetes |
Journal Review |
Journal of Biological Chemistry |
Journal of Neurochemistry |
Journal of Nutritional Sciences |
Endocrinology |
Experimental Eye Research |
Metabolism |
Nature |
American Diabetes Association |
American Journal of Physiology |
Cell Biology and Neuroscience |
Diabetes Care |
Diabetologia |
Journal of Leukocyte Biology |
Cell Transplantation |
European Journal of Pharmacology |
FASEB Journal |
Journal of Clinical Investigation |
Nitric Oxide Journal |
Obesity Research |
Molecular and Cellular Biology |
Nature Medicine |
Biochemical Pharmacology |
Brain Research |
Journal of Immunology |
Journal of Virology |
Molecular Endocrinology |
Molecular Pharmacology |
Transplantation |
DNA and Cell Biology |
Regulatory Peptides |
Free Radical Biology and Medicine |
Electrophoresis |
Cell Metabolism |
Infection and Immunity |
Immunology Letters |
Hormone and Metabolic Research |
Diabetes |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2000 Advisory Board Member, Meetings, 1-3, Nitric Oxide Society for International Nitric Oxide |
2002 Advisory Board Member, Meetings, 1-3, Nitric Oxide Society for International Nitric Oxide |
2004 Advisory Board Member, Meetings, 1-3, Nitric Oxide Society for International Nitric Oxide |
2005 - 2006 Member, Faculty of 1000-Physiology |
2010 Member, External Tenure/Promotion Committee, Harvard University |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Role of Nitric Oxide in β-cell Destruction, Plenary Lecture 15th International Diabetes Congress, Kobe, Japan, 1994 |
Expression of iNOS in NOD Mouse Islets During Autoimmune Destruction, March Atherosclerosis Forum, Courchevel, France, 1995 |
Effects of Cytokines on Human Islet Function, Department of Medical Cell Biol. Uppsala University and Center for Diabetes Research Grad. Course: Frontiers in Diabetes Research II, Uppsala, Sweden, 1995 |
Role of Nitric Oxide in β-cell Dysfunction, Plenary Lecture, NO in Atherosclerosis, Diabetes Mellitus, and Intensive Care, Stockholm, Sweden, 1995 |
Role of IFN-γ and IL-1β in iNOS Expression by Rat and Human Islets of Langerhans, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Melbourne, Australia, 1996 |
Basic Science-Biochemistry and the Development of Diabetes, Juvenile Diabetes Foundation Australia, JDFA Research Information Evening, Sydney, Australia, 1996 |
The Role of Nitric Oxide in the Development and Recurrence of Autoimmune Diabetes, Endocrine Cell Transplantation and Genetic Engineering. International Symposium, Giessen, Germany, 1996 |
Nitric Oxide and the Development of Autoimmune Diabetes, Novo Nordisk Lecture, Annual Scientific Meeting of the Australian Diabetes Society, Australia, 1996 |
Role of Cytokines and Nitric Oxide in the Development of Autoimmune pment of Autoimmune The John Curtin School of Medical, The Australian National University The John Curtin School of Medical Research, Canberra, Australia, 1996 |
Cytokines and β-cell Death, Fourth JDF World Conference, Athens, Greece, 1997 |
β-cell Defense and Recovery from Cytokine-mediated Damage, 6th World Congress on Inflammation Invited Lecture, Vancouver, Canada, 2003 |
MtDNA mutations and Diabetes Development, VIII Servier-ISIG Symposia, St. Jean-Cap-Ferrat, Fr., 2007 |
Novel methods to detect peptides: Nothing to FRET about, Cayman Peptide Conference, Barbados, 2010 |
National |
Phosphorylated Proteins Associated with Bacterial Protein Export, Utah Academy of Sciences, Brigham Young University, Provo, UT, 1990 |
IL-1β-Induced Nitric Oxide Production by Islets of Langerhans, Utah State University, Dept. of Chemistry, Biochemistry, and Molecular Biology, Logan, UT, 1991 |
IL-1β-induced Nitric Oxide Formation Mediates Islet β-cell Dysfunction, Predicting and Preventing Diabetes Symposium, San Antonio, TX, 1992 |
Role of Cytokines and Nitric Oxide in IDDM, Nitric Oxide Symposia American Diabetes Association, Las Vegas, NV, 1993 |
A Role for Nitric Oxide and Other Inflammatory Mediators in Cytokine-Induced Pancreatic β-cell Dysfunction and Death, Monsanto/Searle/Washington University School of Medicine Spring Symposium, St. Louis, MO, 1994 |
Role of Nitric Oxide in the Development of Autoimmune Diabetes, Plenary Lecture, 5th Congress of the International Pancreas and Islet Transplant Association, Miami, FL, 1995 |
Nitric Oxide and β-cell Destruction in the Pancreas, FASEB: Experimental Biology Symposium: Role of Nitric Oxide in the Physiology and Pathophysiology of the Digestive System, Washington, DC, 1996 |
Human Macrophage Activation: Effects of “Local” Cytokine Release on iNOS Expression and Target Cell Function, Third International Conference Biochemistry and Molecular Biology of Nitric Oxide, Los Angeles, CA, 1998 |
Mechanisms of Viral-induced β-cell Damage, Neocrin Company, Irvine, CA, 1998 |
Role of Resident Islet Macrophage Activation as one Potential Initiation Event in the Development of Autoimmune Diabetes, Department of Pathology and Immunology, University of Florida, Gainesville, FL, 1999 |
Role of Resident Islet Macrophage Activation as one Potential Initiation Event in the Development of Autoimmune Diabetes, Department of Pharmacology, University of Virginia, Charlottesville, VA, 1999 |
Nitric Oxide and Diabetes, Plenary Lecture: Oxygen Society 2000 Annual Meeting, San Diego, CA, 2000 |
Local Cytokine Production in Islets Mediates β-cell Damage, TNF-α an Inflammatory Predictor of Type 1 Diabetes Symposia 61st Annual ADA Meeting, Philadelphia, PA, 2001 |
Mechanisms of β-cell Defense/Recovery from Cytokine Mediated Damage, Department of Immunogenetics University of Pittsburgh, Pittsburgh, PA, 2001 |
Inflammation and the β-cell, ACTOS 2004 Global Leadership Conference, New York, NY, 2004 |
Nitric oxide in the Life and Death of β-cells, Barbara Davis Center for Childhood Diabetes, U. of Col. Health Sci. Center, Denver, CO, 2004 |
PPAR-γ Ligands Activate the UPR in β-cells, Duke University, Department of Medicine Center for Nutritional Research, Durham, NC, 2004 |
Are pancreatic β-cells Active Participants in the Initiation of Autoimmune Diabetes? Cytokines induce β-cell necrosis and HMGB1 release., Department of Biochemistry, University of Kentucky, Lexington, KY, 2005 |
Novel signaling pathways regulating the macrophage antiviral response., University of Alabama at Birmingham, Birmingham, AL, 2006 |
A transgenic approach to study the role of mtDNA mutations in pancreatic β-cell failure, Keystone Symposia, Toward Understanding Islet biology, Taos, NM, 2006 |
Cytokines and β-cell death, MSTP Seminar Series, University of Alabama, Birmingham, AL, 2007 |
Inflammation and Islet Dysfunction, Common Mechanisms of Islet Injury in Type 1 and Type 2 Diabetes - 'Stressors' of Disease, American Diabetes Association 68h Annual Meeting, San Francisco, CA, 2008 |
Transcriptional regulation of cytokine-induced beta cell death. It’s not just apoptosis, Cardiovascular Biology Seminar Series, University of Alabama, Birmingham, AL, 2008 |
Role of Inflammation in islet dysfunction, Iconoclasm Meeting, Sausalito, CA, 2008 |
mtDNA mutation accumulation in beta cells causes beta cell failure and diabetes development, CCST Seminar, University of Alabama, Birmingham, AL, 2008 |
mtDNA muation accumulation and beta cell failure, Department of Biochemistry, University of Kentucky, Lexington, KY, 2008 |
Cytokines, Nitric oxide, and beta cell death, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 2009 |
The mechanisms of pancreatic beta-cell destruction, Southern States Chapter of the American Association of Clinical Endocrinologists Annual Meeting, Birmingham, AL, 2009 |
Regulation of inflammatory gene expression in response to virus infection, Department of Microbiology, University of Alabama, Birmingham, AL, 2009 |
Mechanisms controlling cell fate in response to nitric oxide, Department of Biomedical Engineering University of Alabama at Birmingham, Birmingham, AL, 2009 |
Cytokines, Nitric oxide, and beta cell death, Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, 2009 |
How Does Nitric Oxide Kill Beta Cells?, Distinguished Scientist Seminar Series Department of Cell Biol. & Neuroscience, Mobile, AL, 2009 |
FoxO1 is a primary regulator in the beta cell response to cytokines, 1st Annual Manning Diabetes Symposium, Charlottesville, VA, 2010 |
Out FoxO1ing cytokine-mediated beta cell damage, University of Pittsburg, Dept. of Medicine, Division of Endocrinology, Pittsburg, PA, 2011 |
FoxO1 mediates cytokine-induced beta cell damage, American Diabetes Association Annual Meeting: Innate Immunity And Inflammation Syposia, San Diego, CA, 2011 |
Role of FoxO1 in beta cell responses to cytokines, Experimental Biology 2011 APS Endocrinol. Met. Oxidants, Immunity, beta cells and diabetes, Washington, DC, 2011 |
Regional |
IL-1-Induced Nitric Oxide Production by Islets of Langerhans, Utah State University Dept. of Chemistry,Biochemistry, and Molecular Biology, Logan, UT, 1991 |
Nitric Oxide and Autoimmune Diabetes, M.D./Ph.D. Seminar Series, St. Louis University School of Medicine, St. Louis, MO, 1995 |
Cellular Signaling Mechanisms Associated with iNOS Expression by β-cells, Grand Rounds, V.A. Hospital at Jefferson Barracks, St. Louis, MO, 1996 |
Role of Nitric Oxide in Autoimmune Diabetes, Department of Pharmacology and Physiology, St. Louis University School of Medicine, St. Louis, MO, 1996 |
Cytokine-induced iNOS Expression by Human Islets of Langerhans, Diabetes Research Seminar, Washington University School of Medicine, St. Louis, MO, 1996 |
Resident Macrophage Activation as an Initiation Event in Autoimmune Diabetes, Department of Biochemistry, University of Missouri, Columbia, MO, 1997 |
Initiation Events in the Development of Autoimmune Diabetes, Department of Pathology, St. Louis University St. Louis, MO, 1997 |
Initiation Events in the Development of Autoimmune Diabetes, Department of Pathology, St. Louis University St. Louis, MO, 1997 |
Nitric oxide, Cytokines and β-cell Damage, Cardiovascular Group Monsanto-Searle, St. Louis, MO, 1998 |
β-cell Production of IL-1: A Novel Mechanism for Viral-induced β-cell Damage, Department of Cell Biology Parke-Davis, Ann Arbor, MI, 1999 |
Mechanisms of Viral-induced β-cell Damage, Department of Immunology, Cleveland Clinic, Cleveland, OH, 1999 |
Mechanisms of Virus-induced β-cell Damage, Department of Pathology Saint Louis University, St. Louis, MO, 2000 |
β-cell Production of IL-1: A Novel Mechanism for Viral-induced β-cell Damage, Department of Micro-Immunology, Saint Louis University, St. Louis, MO, 2000 |
Potential Triggering Events in the Development of Autoimmune Diabetes: Can β-cells make IL-1?, Joslin Diabetes Center Harvard University, Boston, MA, 2001 |
Role of iPLA2 in the Antiviral Response, Department of Pharmacology, Wayne State University, Detroit, MI, 2002 |
Inflammation and the β-cell, Plenary Lecture:Insulin Action, Insulin Resistance, Inflammation and Atherosclerosis, Niagara Falls, NY, 2002 |
mtDNA Mutations and Diabetes Development: A new Transgenic Model., β-cell Study Group, Washington Univ. School of Medicine, St. Louis, MO, 2003 |
Protection of β-cells from cytokine-Damage, Grand Rounds: Anesthesiology Mediated Department Saint Louis University, School of Medicine, St. Louis, MO, 2003 |
Protection of β-cells from cytokine-Mediated Damage, Grand Rounds: Gastroenterology Saint Louis University, School of Medicine, St. Louis, MO, 2003 |
β-cell Recovery from IL-1-mediated Damage, Department of Biochemistry Indiana University (IUPUI), Indianapolis, IN, 2003 |
PKR-independent Activation of the Antiviral Response in Macrophages, Dept. Mol. Micro. and Immunology Saint Louis University, School of Medicine, St. Louis, MO, 2004 |
Relationship between β-cell Dysfunction and β-cell apoptosis, NDEI Beta Cell Conference, Chicago, IL, 2004 |
Mechanisms of Cytokine-mediated β-cell Death, Beta-cell Turnover Symposium American Diabetes Association 64th Annual Meeting, Orlando, FL, 2004 |
Do we need PKR to Activate the Antiviral Response?, Dept. of Medicine, Div. of Infectious Disease, Saint Louis University, School of Medicine, St. Louis, MO, 2004 |
Nitric oxide in the Life and Death of β-cells, Student Invited Speaker, Dept. of Biology Saint Louis University, St. Louis, MO, 2004 |
Nitric oxide in the Life and Death of β-cells, Department of Physiology, University of Michigan, Ann Arbor, MI, 2004 |
Do we need PKR to Activate the Antiviral Response?, Grand Rounds: Gastroenterology Saint Louis University, School of Medicine, St. Louis, MO, 2005 |
How do cytokines kill β-cells?, Indiana University School of Medicine, Indianapolis, IN, 2006 |
How do cytokines kill β-cells?, Islet Cell Resource Center Consortium Islet Workshop Meeting, Minneapolis, MN, 2006 |
Novel signaling pathways regulating the macrophage antiviral response, Cleveland Clinic, Cleveland, OH, 2006 |
Identification of novel dsRNA signaling receptors, Department of Biochemistry, St. Louis University, St. Louis, MO, 2007 |
Do mtDNA mutations contribute to diabetes development?, Molecular and Cellular Pathology, University of Alabama, Birmingham, AL, 2007 |
Beta cell death by nitric oxide: is it necrosis, apoptosis or both?, Society for Free Radical Biology and Medicine, 15th Annual Meeting, Indianapolis, ID, 2008 |
Do mtDNA mutations predispose beta cells to failure?, Department of Physiology University of Minnesota, Minneapolis, MN, 2008 |
Do mtDNA mutations predispose beta cells to failure?, Dept. of Medicine, Div of Endocrinol. Council for Nutrition, University of Chicago, Chicago, IL, 2008 |
Mechanisms of cytokine-induced beta cell death, Eli Lilly, Metabolic Disease Group, Indianapolis, ID, 2009 |
Control of Beta Cell Fate in response to Nitric Oxide, Department of Pharmacology and Physiology,, St. Louis, MO, 2010 |
Local |
Role of Nitric Oxide in Autoimmune Diabetes, University of Wisconsin-Madison Dept. Endocrinology-Reproductive Physiology, Madison, WI, 1995 |
Nitric Oxide, Cytokines and Autoimmune Diabetes, American Chemical Society Regional Meeting, Saint Norbert College, DePere, WI, 1997 |
Determination of Beta Cell Fate in Response to Nitric oxide: Necrosis, Apoptosis and Sirt1, Max Magee Childhood Diabetes Center Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, 2009 |
Do mtDNA mutations predispose beta cells to failure, Department of Biochemistry Medical College of Wisconsin, Wauwatosa, WI, 2009 |
mtDNA mutations predispose beta cells to failure, Cardiovascular Disease Center, Medical College of Wisconsin, Milwaukee WI, 2010 |
CCR5 and innate immune responses to virus infection, Infectious Disease Research Conference, Medical College of Wisconsin, Milwaukee WI, 2010 |
Cytokines and beta cell fate, Grand Rounds, Endocrionology, Medical College of Wisconsin, Milwaukee WI, 2011 |
Role of Sirt1 and FoxO1 in regulation for of Beta cell responses to NO, Department of Biochemistry, Medical College of Wisconsin, 2011 |
EXTRAMURAL TEACHING: |
Medical Student Education |
1995 - 2007 Lecturer |
1997 - 2007 Metabolism: Course Director |
1997 - 2007 Nitric Oxide Physiology and Pathology |
Glycolysis, Gluconeogenesis, Glycogen Metabolism |
Graduate Student Education |
1996 - 2002 Mentor Grant Writing |
1996 Biology of Nitric Oxide |
1996 - 1998 Cell-cell interactions in islets of Langerhans |
1998 Biochemistry of PKR |
1999 - 2007 Colloquium Biochemistry: Course Director |
2003 - 2007 Diabetes from the β-cell Perspective |
2004 Mentor Grant Writing |
2006 Mentor Grant Writing |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
MS Committees |
2011 Jamie Wieting, Biochemistry, Medical College of Wisconsin |
Postdoctoral Researchers |
2011 - Present Dominique Fontanilla, Innovation Research Grant Recipient, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
1996 Madhu Pocha, Pfizer Award Winner, Engelmann Math and Science Institute |
1997 Christina Wiegand, Pfizer Award Winner, Engelmann Math and Science Institute |
1998 Christine Ekenga, Engelmann Math and Science Institute |
2004 - 2005 Julie Unverferth |
2011 Shanice Davis, ROADS Program |
Undergraduate Students |
1996 Dana Goodnight, St. Louis University School of Medicine |
2002 - 2004 Matthew Basler, St. Louis University School of Medicine |
2003 Bithika Saha, St. Louis University School of Medicine |
2005 - 2007 Julie Unverferth, University of Missouri |
2011 Mitch Armstrong |
Medical Students |
1996 - 1999 Marc Arnush, Awards: First Place AOA, 1997; Presentation at the 37th National Student Research Form, 1997. Griffith Award in Biochemistry, 1997. Current Position, Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA |
1997 Brian Schirf, St. Louis University School of Medicine |
1997 John Vandover, St. Louis University School of Medicine |
1998 - 2000 Josephine Quan-Concepcion, Awards: Third Place AOA, 1999. Griffith Award in Biochemistry, 1999. Current Position, Resident, Washington University School of Medicine, St. Louis, MO |
1999 Michael Ombrello, St. Louis University School of Medicine |
2000 - 2003 Sheri Y. Nishimoto, Awards: First Place AOA, 2002; Presentation at the 42th National Student Research Form, 2002; 2002. Griffith Award in Biochemistry, 2002. Current Position, Resident, Washington University School of Medicine, St. Louis, MO |
2001 - 2004 Elizabeth Richart, Second Place AOA, 2004. Griffith Award in Biochemistry, 2004. Current Position, Resident, Washington University School of Medicine, St. Louis, MO |
2002 John Sorrel, St. Louis University School of Medicine |
2003 - 2005 Leslie Carruthers, Awards: First Place AOA, 2005; Presentation at the 47th National Student Research Form and first place winner of The McLaughlin Award, From The Institute for Human Infections & Immunity Best Poster Presentation On Immunology and Infectious Diseases, 2006. Griffith Award in Biochemistry, St. Louis University School of Medicine |
2004 Julie Terry, St. Louis University School of Medicine |
2005 Jeff Spencer |
Graduate Students |
MS Students Advised |
1996 - 1999 Monique R. Heitmeier, Awards: Sigma Xi Outstanding Research Award (1996), Saint Louis University Graduate Student Association Scientific Research Award (1998). Current Position Research Scientist, Pfizer Global Research and Development, St. Louis University School of Medicine |
1998 - 2002 Libby A. Blair, Awards: NRSA Postdoctoral Fellowship 2003-06: American Society for Bone and Mineral Research Young Investigator Award, 2004. Current Position, Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO |
1998 Helen E. Thomas, Awards: JDRF Australia Travel Grant (1998). From Dr. Thomas W.H. Kay’s laboratory at the Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia. Current Position, Senior Research Officer, St. Vincent's Institute, Melbourne, Victoria, Australia |
1998 - 2001 Leonard B. Maggi, Awards: Sigma Xi Outstanding Research Award (2000), Postdoctoral Research Traineeship from the Department of Defense Prostate Cancer Research Program (2004-06). Current Position, Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO |
2000 - 2004 Sarah M. Weber, Awards: Saint Louis University Graduate Student Association Scientific Research Award (2002); Juvenile Diabetes Research Foundation Postdoctoral Fellowship (2004-2006). Current Position, Postdoctoral Fellow, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, CO |
2001 - 2005 Sarah A. Steer, Awards: AHA Predoctoral Fellowship (2002-2004). Current Position Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO |
2001 - 2006 Jason M. Moran, Awards: Top student presentation Biochemistry and Molecular Biology Department Retreat, 2001, American Society for Virology Student Travel Award, 2003, Davis CA. NRSA Postdoctoral Fellowship (7/06-6/09) Postdoctoral Fellow Northwestern University, Evanston, IL, Tekada North American, Philadelphia, PA |
2002 - 2007 Kari T. Chambers, Awards: AHA Predoctoral Fellowship (2004-06); Saint Louis University Graduate Student Association Scientific Research Award (2005). Inducted in to Sigma Xi (2003) and Alpha Sigma Nu National Jesuit Honor Society (2005). Current Position, Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO |
2003 - 2005 Tricia A. Missall, Biochemistry, St. Louis University School of Medicine |
2005 - 2010 Alison (Sexton) Salvatori, Awards: Saint Louis University Presidential Research Assistantship (2005-07). Saint Louis University Graduate Student Association Scientific Research Day, First Place (2006)., St. Louis University School of Medicine |
2005 - 2010 Katie Hughes, Awards: NIH Predoctoral Fellowship, Pharmacological Sciences Training Grant, 2006-2007. Saint Louis University Graduate Student Association Scientific Research day, Second Place, St. Louis University School of Medicine |
2005 - 2009 Ben Christman, Saint Louis University Graduate Stipend (2006). NIH T32 Immunology Training Grant Fellowship, UAB (2009). Current Position: Postdoctoral Fellowship, University of Alabama, Birmingham, AL |
2007 - Present Aaron Baldwin, Department of Biochemistry, Medical College of Wisconsin |
2008 Joeseph Daft, Pathology Graduate Program, UAB. Remained at UAB following our move to MCW., St. Louis University School of Medicine |
2009 Dennis Steverson Jr, Louis Stokes Alliances for Minority Participation (LSAMP) Program, Bridge to a Doctorate 20009-2010 Predoctoral Fellowship Stipend. Remained at UAB following our move to MCW, St. Louis University School of Medicine |
2011 - Present Bryndon Oleson |
MS Committees |
1996 - 1999 Laura Bohn, Biochemistry, St. Louis University |
1996 Lois Richard, MD/PhD and CMB, St. Louis University |
1996 - 1999 Wilhelm Cruz, Biochemistry, St. Louis University |
1996 - 1999 Scott Happe, Biochemistry, St. Louis University |
1997 - 2000 Scott Williams, Biochemistry, St. Louis University |
1998 Troy Baudino, CMB, St. Louis University School of Medicine |
1998 - 2002 Joe Vetro, Biochemistry, St. Louis University |
1999 Aaron J. Marrow, Biochemistry, St. Louis University |
1999 John T. Swarthout, CMB, St. Louis University School of Medicine |
2000 - 2004 Michelle Farberman, Pathology, St. Louis University School of Medicine |
2001 - 2004 Rebecka Durst, MMI, St. Louis University School of Medicine |
2002 - 2005 Eric Knoll, Biochemistry, St. Louis University School of Medicine |
2003 - 2007 Kenneth M. Scaglione, Biochemistry, St. Louis University School of Medicine |
2005 Dhanalakshmi Subramanian, Biochemistry, St. Louis University School of Medicine |
2005 Sarah Brown, Biochemistry, St. Louis University School of Medicine |
2005 - 2006 Suzanne Vinson, Pathology, St. Louis University School of Medicine |
2005 Ling Tian, Biochemistry, St. Louis University School of Medicine |
2006 Jennifer Paige Mackey, MMI, St. Louis University School of Medicine |
2006 - Present Chirs Wiley, MMI, St. Louis University School of Medicine |
2008 - 2010 Paige DeBenedittis, Genetics, University of Alabama |
2008 - 2010 Shaoning Jiang, Pathology, University of Alabama |
2008 - 2010 Brian L. Dizion, MSTP program/ Immunology, University of Alabama |
2008 David Liuwantara, external reviewer, University of New South Wales |
2009 - 2010 Colin Reily, Pathology, University of Alabama |
2009 Mark David Mckenzi, external reviewer, University of Melbourne |
2010 Thanya Suwanthi Samarasekera, external reviewer, University of Melbourne |
PhD Students Advised |
1998 - 2002 Justin Mott, Joint Mentor with Dr. Hans Peter Zassenhaus, Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine |
2003 - 2007 April Keim, Joint Mentor with Dr. R. Mark Buller, Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine |
2004 - 2008 Kenneth G. Bensch, Awards: Saint Louis University Presidential Scholarship (2004-08). NIH Predoctoral Fellowship AG029104-01 ($151,280 direct costs, 6/1/06-5-31-11). Physician Scientist Training Award, American Diabetes Association (declined in favor of the NIH award)., St. Louis University School of Medicine |
2005 - Present Wieke, de Graaf, M.D., Awards: Physician Scientist Training Award, American Diabetes Association |
2011 - Present Zachary Shaheen |
Postdoctoral Researchers |
1996 - 2000 Anna L. Scarim, Current Position: Sigma Chemical Co. St. Louis, MO., St. Louis University School of Medicine |
2008 - Present Gordon Meares, 2008-Trainee on the NIAID funded Program in Immunology grant T32 07051. 2009: NRSA Postdoctoral Fellowship F32DK084645, Mechanisms regulating functional beta cell recovery. |
Faculty |
2000 - 2006 Anna L. Scarim, Ph.D, Research Assistant Professor, Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine |
2002 - 2007 Teresa L Andreone, M.D./Ph.D., Assistant Professor, Department of Pediatrics, Saint Louis University School of Medicine. Awards: Saint Louis University Research Award for fostering projects between clinical and basic science faculty (2003). Mentor for this award., St. Louis University School of Medicine |
2003 - 2007 Jonathan Fisher, Ph.D., Title: Associate Professor, Department of Biology, Saint Louis University. Awards: NIH KO8 Award (2004-09). Mentor for this award., St. Louis University School of Medicine |
CONSULTANT/ADVISORY BOARDS: |
1998 Neocrin Co., Anaheim, CA |
2000 - 2002 Monsanto –Searle, St. Louis, MO |
2000 - 2001 Parke-Davis/Pfizer, Ann Arbor, MI |
2002 - 2006 Washington University School of Medicine, Human Islet Isolation Core Facility |
2003 - 2005 BioRexis, King of Prussia, PA |
2008 Xoma, Scientific Advisory Board Meeting, Atlanta, Ga. |
2009 Novo Nordisk, Scientific Advisory Board Meeting, Dallas, Tx. |
2010 Saint Norbert College, DePere Wi, New Science Building Advisory Board |
DOCTORAL DISSERTATION: |
1990 John A. Corbett The Energetic Requirements for Bacterial Protein Export, Department of Chemistry and Biochemistry, Utah State University, Logan, UT |
LICENSING AGREEMENTS: |
1994 - 2001 Alteon |
2004 - Present Vi Jon |
2007 - Present Gold Biotechnology. Method for enhanced detection of antigens. |
MEETING ORGANIZATION: |
2009 Experimental Biology New Orleans, 2009: American Physiological Society: Metabolic Diseases:
Session 383. Insulin from regulated expression to regulated secretion. |
2011 Experimental Biology Washington DC, 2011: American Physiological Society: Metabolic Diseases
Oxidants, Immunity, beta cells and diabetes |
PATENTS: |
Moxley, MA, Waheed, A, Corbett, JA, and Sly, WS. Method for enhanced detection of antigens. Patent
submitted 10-07. |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
European Patent # 0771195 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
Japan Patent # 3251673 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
European Patent # 0547558 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
US Patent # 5,358,969 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
US Patent # 5,246,971 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
US Patent # 5,246,970 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
Australian Patent # 688,370 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
Canadian Patent # 2,169,481 |
Williamson, JR, Corbett, JA, , McDaniel, ML, and Tilton, RG. Inhibition of Nitric Oxide Formation in
Inflammatory Bowel Disease. US Patent # 5,710,181 |
McDaniel, ML, Hill, JR, and Corbett, JA. Method of Inhibiting the Release of Bioactive IL-1. US Patent #
5,780,513 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
New Zealand Patent # 273167 |
Williamson, JR, Corbett, JA, Tilton, RG, and McDaniel, ML. Method for Inhibiting Nitric Oxide Formation.
US Patent # 5,837,738 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Corbett, JA, Lancaster, Jr., JR, Sweetland, MA, and McDaniel, ML. 1991. Interleukin 1-Induced Formation of EPR-Detectable Iron-Nitrosyl Complexes in Islets of Langerhans: Role of Nitric Oxide in IL-1-Induced Inhibition of Insulin Secretion. J. Biol. Chem. 266, 21351-21354, PMID: 1334975. |
2. Corbett, JA, Tilton, RG, Chang, K, Hasan, KS, Ido, Y, Wang, JL, Sweetland, MA, Lancaster Jr., JR, Williamson, JR, and McDaniel, ML. 1992. Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction. Diabetes 41, 552-556, PMID: 7678825. |
3. Corbett, JA, and McDaniel, ML. 1992. Does Nitric Oxide Mediate Autoimmune Destruction of -cells? Possible Therapeutic Interventions in IDDM. Diabetes 41, 897-903, PMID: 1378415. |
4. Corbett, JA, Wang, JL, Hughes, JH, Wolf, BA, Sweetland, MA, Lancaster Jr., JR, and McDaniel, ML. 1992. Nitric Oxide and cGMP Formation Induced by Interleukin 1 in Islets of Langerhans: Evidence for an Effector Role of Nitric Oxide in -cell Dysfunction. Biochem. J. 287, 229-235, PMID: 1384465. |
5. Corbett, JA, Wang, JL, Sweetland, MA, Lancaster Jr., JR, and McDaniel, ML. 1992. IL-1 Induces the Formation of Nitric Oxide by -cells Purified from Rodent Islets of Langerhans: Evidence for the -cell as a Source and Site of Action of Nitric Oxide. J. Clin. Invest. 90, 2384-2391, PMID: 1334975. |
6. Corbett, JA, Sweetland, MA, Wang, JL, Lancaster Jr., JR, and McDaniel, ML. 1993. Nitric Oxide Mediates Cytokine-Induced Inhibition of Insulin Secretion by Human Islets of Langerhans. Proc. Natl. Acad. Sci. U.S.A. 90, 1731-1735, PMID: 8383325. |
7. Corbett, JA, Sweetland, MA, Lancaster Jr., JR, and McDaniel, ML. 1993. A 1 Hour Pulse with IL-1 Induces the Formation of Nitric Oxide and Inhibits Insulin Secretion by Rat Islets of Langerhans: Evidence for a Tyrosine Kinase Signaling Mechanism. FASEB J. 7, 369-374, PMID: 8440413. |
8. Tilton, RG, Chang, K, Hasan, KS, Smith, S, Petrash, MJ, Misko, TP, Moore, WM, Currie, MG, Corbett, JA, McDaniel, ML, and Williamson, JR. 1993. Prevention of Diabetic Vascular Dysfunction by Aminoguanidine and Methylguanidine: Inhibition of Nitric Oxide Synthase Versus Inhibition of Advanced Glycation Endproduct Formation. Diabetes 42, 221-232, PMID: 7678825. |
9. Misko, TP, Moore, WM, Kasten, TP, Nickols, GA, Corbett, JA, Tilton, RG, McDaniel, ML, Williamson, Jr., JR, and Currie, MG. 1993. Selective Inhibition of the Inducible Nitric Oxide Synthase by Aminoguanidine. Eur. J. Pharmacol. 233, 119-125, PMID: 7682510. |
10. Wang, JL, Corbett, JA, Marshall, C, and McDaniel, ML. 1993. Glucose-induced Insulin Secretion from Purified -cells: A Role for Modulation of Intracellular Ca2+ by cAMP- and Protein Kinase C-Dependent Signal Transduction Pathways. J. Biol. Chem. 268, 7785-7791, PMID 8385120. |
11. Beckerman, KP, Rogers, HW, Corbett, JA, Schreiber, RD, McDaniel, ML, and Unanue, ER. 1993. Release of Nitric Oxide During the T-cell Independent Pathway of Macrophage Activation: Its Role in Resistance to Listeria monocytogenes. J. Immunol. 150, 888-895, PMID: 7678626. |
12. Corbett, JA, Wang, JL, Misko, TP, Zhao, W, Hickey, WF, and McDaniel, ML. 1993. Nitric Oxide Mediates IL-1-induced Islet Dysfunction and Destruction: Prevention by Dexamethasone. Autoimmunity 15, 145-153, PMID: 7692996. |
13. Mandrup-Poulsen, T, Corbett, JA, McDaniel, ML, and Nerup, J. 1993. What are the Types and Cellular Sources of Free Radicals in the Pathogenesis of Type 1 (insulin-dependent) Diabetes Mellitus. Diabetologia 36, 470-471, PMID: 7686111. |
14. Schmidt, RE, Dorsey, DA, McDaniel, ML, and Corbett, JA. 1993. Differential Distribution of NADPH Diaphorase Activity in Rat Paravertebral and Prevertebral Sympathetic Autonomic Ganglia: Effect of Diabetes and Aging. Brain Res. 617, 343-348, PMID: 8104662. |
15. Hewett, SJ, Corbett, JA, McDaniel, ML, and Choi, DW. 1993. Inhibition of Nitric Oxide Formation Does Not Protect Murine Cortical Cell Cultures from N-methyl-D-aspartate Neurotoxicity. Brain Res. 625, 337-341, PMID 8275317. |
16. Corbett, JA, Mikhael, A, Shimizu, J, Frederick, K, Misko, TP, McDaniel, ML, Kanagawa, O, and Unanue, ER. 1993. Nitric Oxide Production in NOD Islets-Aminoguanidine Sensitive and Resistant Stages in the Immunological Diabetic Process. Proc. Natl. Acad. Sci. U.S.A. 90, 8992-8995, PMID 7692442. |
17. Hasan, K, Heesen, BJ, Corbett, JA, McDaniel, ML, Wolffenbuttel, BHR, Williamson, JR, and Tilton, RG. 1993. Inhibition of Nitric Oxide Synthase by Guanidine Analogues. Eur. J. Pharmacol. 249, 101-106, PMID: 7506664. |
18. Ellman, C, Corbett, JA, McDaniel, ML, and Beckerman, K. 1993. Nitric Oxide Mediates IL-1-induced Cellular Cytotoxicity in the Rat Ovary: A Role for Nitric Oxide in Tissue Remodeling During Ovulation. J. Clin. Invest. 92, 3053-3056, PMID: 7504698. |
19. Corbett, JA, Kwon, G, Turk, J, and McDaniel, ML. 1993. IL-1 Induces the Coexpression of both Nitric Oxide Synthase and Cyclooxygenase by Islets of Langerhans: Activation of Cyclooxygenase by Nitric Oxide. Biochemistry 32, 13767-13770, PMID: 7505613. |
20. Turk, J, Corbett, JA, Ramanadham, S, Bohrer, A, and McDaniel, ML. 1993. Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets. Biochem. Biophys. Res. Commun. 197, 1458-1464, PMID: 7904159. |
21. Hewett, SJ, Corbett, JA, McDaniel, ML, and Choi, DW. 1993. Interferon- and Interleukin-1 Induce Nitric Oxide Formation from Primary Mouse Astrocytes. Neurosci. Lett. 164, 229-232, PMID: 7512249. |
22. Nixon-Heiss, LJ, Lancaster, JR, Jr., Corbett, JA, and Goldman, WE. 1994. Induction of Nitric Oxide Synthesis in Respiratory Epithelium: Role in the Cytopathology of Pertussis. Proc. Natl. Acad. Sci. U.S.A. 91, 267-270, PMID: 7506415. |
23. Aguilar-Diosdado, M, Parkinson, D, Corbett, JA, Kwon, G, Marshall, CA, Gingerich, RL, Santiago, JV, and McDaniel ML. 1994. Potential Autoantigens in Insulin-dependent Diabetes Mellitus: Expression of Carboxypeptidase-H and Insulin but not Glutamate Decarboxylase on the -cell Surface. Diabetes 43, 418-425, PMID: 8314014. |
24. Corbett, JA, and McDaniel, ML. 1994. Reversibility of IL-1-induced Islet Destruction and Dysfunction by the Inhibition of Nitric Oxide Synthase: Evidence for the Induction of Possible Recovery Proteins. Biochem. J. 299, 719-724, PMID: 7514870. |
25. Corbett, JA, Kwon, G, Misko, TP, and McDaniel, ML. 1994. Immunoprecipitation of Inducible Nitric Oxide Synthase from Purified -cells of Islets of Langerhans: Potential Role of Tyrosine Kinase Activation in IL-1-induced iNOS Expression. Am. J. Physiol. 267, C48-C54, PMID: 7519400. |
26. Tilton, RG, Chang, K, Corbett, JA, Misko, TP, Currie, MG, Bora, NS, Kaplan, HJ, and Williamson, JR. 1994. Endotoxin-induced Uveitis in the Rat is Attenuated by Inhibition of Nitric Oxide Production. Invest. Ophthalmol. Vis. Sci. 35, 3278-3288, PMID: 7519183. |
27. Corbett, JA, and McDaniel, ML. 1995. Intraislet Release of IL-1 Inhibits -cell Function by Inducing -cell Expression of iNOS. J. Exp. Med. 181, 559-568, PMID: 7530759. |
28. Kwon, G, Corbett, JA, Rodi, CP, Sullivan, PM, and McDaniel, ML. 1995. IL-1 Induces the Expression of Nitric Oxide Synthase by Rat Islets of Langerhans and RINm5F Cells: Evidence for the Involvement of NF-B in the Signaling Mechanism. Endocrinology 136, 4790-4795, PMID: 7588208. |
29. Kwon, G, Corbett, JA, and McDaniel, ML. 1996. IL-1-induced c-Fos and c-Jun do not Regulate Inducible Nitric Oxide Synthase in Rat Islets of Langerhans and RINm5F Cells. Endocrinology 137, 825-830, PMID: 8603591. |
30. Corbett, JA, Kwon, G, Marino, M, Rodi, CP, Sullivan, PM, and McDaniel, ML. 1996. Tyrosine Kinase Inhibitors Prevent Cytokine-induced Expression of iNOS and COX-2 by Human Islets of Langerhans. Am. J. Physiol. 270, C1581-C1587, PMID: 8764139. |
31. Ma, Z, Ramanadham, S, Corbett, JA, Bohrer, A, Gross, RW, McDaniel, ML, and Turk, J. 1996. Mass Spectrometric Evidence that Interleukin-1 Enhances Pancreatic Islet 12-Lipoxygenase Product Generation by Increasing Substrate Availability through a Nitric Oxide-dependent Mechanism. J. Biol. Chem. 271, 1029-1042, PMID: 8557627. |
32. Denlinger, LC, Fisette, PL, Garis, KA, Kwon, G, Vazquez-Torres, A, Simon, AD, Nguyen, B, Proctor, RA, Bertics, PJ, and Corbett, JA. 1996. Regulation of Inducible Nitric Oxide Synthase Expression by Macrophage Purinoreceptors and Calcium. J. Biol. Chem. 271, 337-342, PMID: 8550583. |
33. Hill, JR, Corbett, JA, Baldwin, AC, and McDaniel, ML. 1996. Nitric Oxide Production by the Rat Insulinoma Cell Line, RINm5F, is Specific for IL-1: A new IL-1 Bioassay. Anal. Biochem. 236, 14-19, PMID: 8619479. |
34. Kwon, G, Bohrer, A, Han, X, Corbett, JA, Ma, Z, Gross, R, McDaniel, ML, and Turk, J. 1996. Characterization of the Sphingomyelin Content of Isolated Pancreatic Islets. Evaluation of the Role of Sphingomyelin Hydrolysis in the Action of Interleukin-1 to Induce Islet Overproduction of Nitric Oxide. Biochem. Biophys. Acta 1300, 63-72, PMID: 8608164. |
35. Hill, JR, Corbett, JA, Kwon, G, Marshall, CA, and McDaniel, ML. 1996. Nitric oxide Regulates Interleukin 1 Bioactivity Released from Murine Macrophages. J. Biol. Chem. 271, 22672-22678, PMID: 8798439. |
36. Meredith, M, Rabaglia, ME, Corbett, JA, and Metz, SA. 1996. Dual Functional Effects of Interleukin-1 on Purine Nucleotides and Insulin Secretion in Rat Islets and INS-1 Cells. Diabetes 45, 1783-1791, PMID: 8922366. |
37. Zhao, W, Tilton, RG, Corbett, JA, McDaniel, ML, Misko, TP, Williamson, JR, Cross, AH, and Hickey, WF. 1996. Experimental Allergic Encephalomyelitis in the Rat is Inhibited by Aminoguanidine, an Inhibitor of Nitric Oxide Synthase. J. Neuroimmunol. 64, 123-133, PMID: 8632054. |
38. Carroll, SL, Miller, ML, Frohnert, PW, Kim, SS, and Corbett, JA. 1997. Expression of Neuregulins and Their Putative Receptors, ErbB2 and ErbB3, is Induced During Wallerian Degeneration. J. Neurol. Sci. 17, 1642-1659, PMID: 9030624. |
39. Hansen, PA, Corbett, JA, and Holloszy, JO. 1997. Phorbol Esters Stimulate Muscle Glucose Transport by a Mechanism Distinct from the Insulin and Hypoxia Pathways. Am. J. Physiol. 273, E28-E36, PMID: 9252476. |
40. Kwon, G, Hill, JR, Corbett, JA, and McDaniel, ML. 1997. Effects of Aspirin on Nitric Oxide Formation and De Novo Protein Synthesis by RINm5F Cells and Rat Islets. Mol. Pharmacol. 52, 398-405, PMID: 9281601. |
41. Scarim, AL, Arnush, M, Hill, J, Marshall, C, Baldwin, A, McDaniel, ML, and Corbett, JA. 1997. Evidence for the Presence of Type 1 IL-1 Receptors on -cells of Islets of Langerhans. Biochem. Biophys. Acta 1361, 313-320, PMID: 9375806. |
42. Heitmeier, MR, Scarim AL, and Corbett, JA. 1997. IFN- Increases the Sensitivity of Islets of Langerhans for iNOS Expression Induced by IL-1. J. Biol. Chem. 272, 13697-13704, PMID: 9153221. |
43. Cruz, WS, Moxley, MA, Corbett, JA, and Longmore, WJ. 1997. Inhibition of Nitric Oxide Synthase Attenuates NNMU-induced Alveolar Injury in vivo. Am. J. Physiol. 17, L1167-L1173, PMID: 9435571. |
44. Scarim, AL, Heitmeier, MR, and Corbett, JA. 1997. Irreversible Inhibition of Metabolic Function and Islet Destruction Following a 36 h Exposure to IL-1. Endocrinology 138, 5301-5307, PMID: 9389514. |
45. Arnush, M., Scarim, AL, Heitmeier, MR., Kelly, CB, and Corbett, JA. 1998. Activation of Resident Islet Lymphoid Cells and the Initiation of Autoimmune Diabetes: Depletion of Resident Macrophages Prevents -cell Damage. J. Immunol. 160, 2684-2691, PMID: 9510167. |
46. Kwon, G, Corbett, JA, Hauser, S, Hill, JR, Turk, J, and McDaniel, ML. 1998. Evidence for the Involvement of the Proteasome Complex (26S) and NF-B in IL-1-induced Nitric Oxide and Prostaglandin Production by Rat Islets and RINm5F Cells. Diabetes 47, 583-591, PMID: 9568691. |
47. Arnush, M, Manning, PA, Marino, MA, Heitmeier, MR, Scarim, AL, and Corbett, JA. 1998. IL-1 Produced and Released Endogenously within Human Islets Inhibits -cell Function. J. Clin. Invest. 102, 516-526, PMID: 9691088. |
48. Heitmeier, MR, Scarim, AL, and Corbett, JA. 1998. Double-Stranded RNA-induced iNOS Expression and IL-1 Release by Murine Macrophages Requires NF-B Activation. J. Biol. Chem. 273, 15301-15307, PMID: 9614147. |
49. Parkkila, A-K, Scarim, AL, Parkkila, S, Waheed, A, Corbett, JA, and Sly, WS. 1998. Expression of Carbonic Anhydrase V in Pancreatic -cells. J. Biol. Chem. 273, 24620-24623, PMID: 9733757. |
50. Scarim, AL, Heitmeier, MR, and Corbett, JA. 1998. Heat Shock Inhibits Cytokine-induced Nitric Oxide Synthase Expression by Rat and Human Islets. Endocrinology 139, 5050-5057, PMID: 9832444. |
51. Cruz, WS, Corbett, JA, Longmore, WJ, and Moxley, MA. 1998. Nitric Oxide Participates in Early Events Associated with N-nitroso-N-methylurethane-induced Acute Lung Injury in Rats. Am. J. Physiol. 276, L263-L268, PMID: 9950888. |
52. Heitmeier, MR, Scarim, AL, and Corbett, JA. 1999. Double-stranded RNA Inhibits -cell Function and Induces Islet Damage by Stimulating -cell Production of Nitric Oxide. J. Biol. Chem. 274, 12531-12536, PMID: 10212230. |
53. Thomas, HE, Darwiche, R, Corbett, JA, and Kay, TWH. 1999. Evidence that -cell Death in the Non-Obese Diabetic Mouse is Fas-independent. J. Immunol. 163, 1562-1569, PMID: 10415060. |
54. Heitmeier, MR, Scarim, AL, and Corbett, JA. 1999. Prolonged STAT1 Activation is Associated with IFN- Priming for IL-1-induced iNOS Expression by Islets of Langerhans. J. Biol. Chem. 274, 29266-29273, PMID: 10506184. |
55. Maggi, L, Sadeghi, H, Weigand, C, Scarim, AL, Heitmeier, MR, and Corbett, JA. 2000. Anti-inflammatory Actions of 15-d- 12,14-prostaglandin J2 and Troglitazone: Evidence for Heat Shock-dependent and -independent Inhibition of Cytokine-induced iNOS Expression. Diabetes 49, 346-355, PMID: 10868955. |
56. Koster JC, Marshall, BA, Ensor, N, Corbett, JA, and Nichols, CG. 2000. Targeted overactivity of -cell KATP channels induces profound neonatal diabetes. Cell 100, 645-654, PMID: 10761930. |
57. Moxley, MA, Baird, T, and Corbett, JA. 2000. Adoptive Transfer of Lung Disease. Am. J. Physiol. 279, L985-L993, PMID: 11053036. |
58. Maggi, L, Heitmeier, MR, Scheuner, D, Kaufman RJ, Buller, MRL, and Corbett, JA. 2000. Potential Role of PKR in dsRNA-induced Macrophage Activation. EMBO J. 19, 3630-3638, PMID: 10899117. |
59. Blair, LA, Heitmeier, MR, Scarim, AL, Maggi, LB, Jr., and Corbett, JA. 2001. PKR is not required for double-stranded RNA-induced iNOS expression or NF-B activation by islets. Diabetes 50, 283-290, PMID: 11272138. |
60. Heitmeier, MR, Arnush, M, Scarim, AL, and Corbett, JA. 2001. IL-1 Produced and Released by Pancreatic -cells Mediates -cell Damage in Response to dsRNA + IFN-. J. Biol. Chem. 276, 11151-11158, PMID: 9691088. |
61. Scarim, AL, Arnush, M, Blair, LA, Concepcion, J, Heitmeier, MR, Ryerse, J, Scheuner, D, Kaufman, RJ, Buller, RML, and Corbett, JA. 2001. Mechanisms of -cell Death in Response to dsRNA and IFN-: PKR-dependent Apoptosis, and Nitric Oxide-dependent Necrosis. Am. J. Pathol. 159, 273-283, PMID: 11438474. |
62. Hudson, TY, Corbett, JA, Howlett, AC, and Klein, C. 2001. Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes. J. Neurochem. 77, 1297-1284, PMID: 11389178. |
63. Thomas, HE, Darwiche, R, Corbett, JA, and Kay, TWH. 2002. Interleukin-1 and interferon--induced pancreatic beta cell dysfunction is mediated by beta-cell nitric oxide production. Diabetes 51, 311-316, PMID: 11812737. |
64. Blair, LA, Maggi, LB, Scarim, AL, and Corbett, JA. 2002. The Role of Interferon Regulatory Factor-1 in Double-stranded RNA-induced iNOS Expression by Mouse Islets. J. Biol. Chem. 277, 359-365, PMID: 11694524. |
65. Maggi, LB, Jr., Moran, JM, Scarim, AL, Ford, DA, Yoon, JW, McHowat, J, Buller, MRL, and Corbett, JA. 2002. Novel role for iPLA2 in the Antiviral Response of Macrophages. J.Biol. Chem. 277, 38449-38455, PMID: 12167650. |
66. Maggi, LB, Jr., Moran, JM, Buller, RML, and Corbett, JA. 2003. ERK activation is required for dsRNA- and virus-induced IL-1 expression by macrophages. J. Biol. Chem. 278, 16683-16689, PMID: 12609986. |
67. Steer, SA, Moran, JM, Maggi, LB, Jr., Buller, RML, Perlman, H, and Corbett, JA. 2003. Regulation of COX-2 expression in response to dsRNA and viral infection. J Immunol. 170, 1070-1076, PMID: 12517975. |
68. Weber, SM, Scarim, AL, and Corbett, JA. 2003. Inhibition of IFN--induced STAT-1 activation by 15-deoxy- 12, 14-prostaglandin J2. Amer. J. Physiol. Endocrinol. Metab. 284, E883-E891, PMID: 12517740. |
69. Scarim, AL, Nishimoto, SY, Weber, SM, and Corbett, JA. 2003. Role for JNK in -cell recovery from nitric oxide-mediated damage. Endocrinonl. 144, 3415-3422, PMID: 1286530. |
70. Martinson, B.D., Albert, C.J., Corbett, J.A., Wysolmerski, R., and Ford, D.A. 2003. Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA stimulated endothelial cells. J. Lipid Res. 44, 1686-1691, PMID: 12810819. |
71. Weber, SM, Scarim, AL, and Corbett, JA. 2004. PPAR- is not required for the inhibitory actions of 15-deoxy 12, 14 prostaglandin J2 on cytokine signaling in pancreatic -cells. Amer. J. Physiol. Endocrinol. Metab. 286, E329-E336, PMID: 14600076. |
72. Mosley, A.L., Corbett, J.A., and Ozcan S. 2004. Glucose Regulation of Insulin Gene Expression Requires the Recruitment of p300 by the Beta-cell Specific Transcription Factor Pdx-1. Mol. Endocrinol. 18, 2279-2290, PMID: 15166251. |
73. Heitmeier, MR, Kelly, CB, Ensor, NJ, Gibson, KA, Mullis, KG, Moxley, MA, Corbett, JA, and Maziasz, TJ. 2004. Role of Cyclooxygenase-2 in Cytokine-induced -cell Dysfunction and Damage by Isolated Rat and Human Islets. J. Biol. Chem. 279, 53145-53151, PMID: 15471850. |
74. Weber, SM, Chambers, KT, Bensch, KG, Scarim, AL, and Corbett, JA. 2004. PPAR- ligands induce ER stress in pancreatic -cells: ER stress activation results in the attenuation of cytokine signaling. Amer. J. Physiol. Endocrinol. Metab. 287, E1171-E1177, PMID: 15315910. |
75. Missall. TA, Moran, JM, Corbett, JA, and Lodge JK. 2005. Distinct stress responses of two functional laccases in Cryptococcus neoformans is revealed in the absence of the thiol-specific antioxidant, Tsa1. Eukaryotic Cell 4, 202-208, PMID: 15643075. |
76. Moran, JM, Buller, RML, McHowat, J, Turk, J, Wohltmann, M, Gross, RW, and Corbett, JA. 2005. Genetic and pharmacologic evidence that calcium-independent phospholipase A2 regulates virus-induced inducible nitric oxide synthase expression by macrophages. J. Biol. Chem. 280, 28162-28168, PMID: 15946940. |
77. Moran, JM, Moxley MA, Buller, RML, and Corbett, JA. 2005. Encephalomyocarditis virus induces PKR-independent mitogen-activated protein kinase activation in macrophages. J. Virol. 79, 10226-10236, PMID: 16051816. |
78. Steer, SA, Scarim, AL, Chambers, KT, and Corbett, JA. 2006. Interleukin 1 stimulates islet cell death by necrosis: Nitric oxide-dependent release of the immunological adjuvant HMGB1 by -cells. PLoS Med. 3, e17, PMID: 16354107. |
79. Missall. TA, Pusateri, ME, Donlin, M, Chambers, KT, Corbett, JA, and Lodge JK. 2006. Posttranslational, Translational, and Transcriptional Responses to Nitric Oxide Stress in Cryptococcus neoformans: Implications for Virulence. Eukaryotic Cell. 5, 518-529, PMID: 16524907. |
80. Steer, SA, Moran, JM, Christmann, B, Maggi, LB, Jr., Corbett, JA. 2006. Virus-induced COX-2 expression is regulated by p38 and JNK. J. Immunol. 177, 3413-3420, PMID: 16920983. |
81. Klein, C, Creach, K, Irintcheva V, Hughes, KJ, Blackwell, PL, Corbett, JA, and Baldassare, JJ. 2006. Zinc Induces ERK-Dependent Cell Death Through a Specific Ras Isoform. Apoptosis. 11, 1933-1944, PMID 17013754. |
82. Chambers, KT, Weber, SM, and Corbett, JA. 2007. PGJ2-stimulated -cell apoptosis is associated with prolonged UPR activation. Am. J. Physiol. Endocrinol. Met. 292, E1052-E1061, PMID: 17148750. |
83. Parker, AK, Parker, S, Yokoyama, WM, Corbett, JA, and Buller, RML. 2007. Induction of natural killer cell responses by Ectromelia virus controls infection. J. Virol. 18:4070-4079, PMID: 17287257. |
84. Parker, AK, Yokoyama, WM, Corbett, JA, Chen, N, and Buller, RML. 2008. Primary naïve and IL-2 activated NK cells do not support a productive ectromelia virus infection. J. Gen. Virol. 89: 751-759, PMID: 18272767. |
85. Chambers KT, Unverferth, JA, Weber, SM, Wek, RC , Urano, F, and Corbett, JA. 2008. The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine Induced -cell Death. Diabetes 57:124-132, PMID: 17928398. |
86. Bensch, KG, Mott, JL, Chen, S-W, Hansen PA, Moxley, MA, Chambers, KT, de Graaf, W, Zassenhaus, HP, and Corbett, JA. 2009. Diabetes induced they random accumulation of mitochondrial DNA mutations in -cells. Am. J. Physiol. Endocrinol. Met. 296: E672-E680. First published January 21, 2009; doi:10.1152/ajpendo.90839.2008, PMID: 19158322. |
87. Scatizzi, JC, Mavers, M, Hutcheson, J, Young, B, Shi, B, Pope, R, Rderman, , Samways, DSK, Corbett, JA, Egan, T, and Perlman, H. 2009. The cyclin dependent kinase inhibitor p21 is a suppressor of IL-1-mediated inflammation in activated macrophages. Eur. J. Immunol. 39: 820-825, PMID: 19189309. |
88. Koeck T, Corbett, JA, Crabb, JW, Stuehr, DJ, and Aulak, KS. 2009. Glucose-modulated tyrosine nitration in beta cells: Targets and consequences. Arch Biochem Biophys. 484:221-231, PMID: 19402213. |
89. Hughes, KJ, Chambers, KT, and Corbett, JA. 2009. Irreversible DNA damage is associated with the induction of caspase activity by nitric oxide in cytokine treated islets of Langerhans. Am. J. Physiol Endocrinol Met. 297: E1187 - E1196, PMID: 19738038. |
90. Evans, SA, Doblado, M, Chi, MM, Corbett JA, and Moley KH. 2009. Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. Endocrionol. 150:5302-10, PMID: 19808778. |
91. Hughes, KJ, Meares, GP, Chambers, KT, and Corbett, JA. 2009. Repair of nitric oxide damaged DNA requires JNK-dependent Gadd45 expression. J. Biol. Chem. 284:27402-27408, PMID: 19648647. |
92. Freudenburg-deGraaf, Moran, JM, Lents, NH, Baldassare, JJ, Buller, RML, and Corbett, JA. 2010 Phosphatidylinositol 3-kinase regulates the proinflammatory response of macrophages to double stranded RNA and Encephalomyocarditis virus. J. Innate Immunity. 2:77-86, PMID: 20375625. |
93. Meares, G.P, Hughes, KJ, Jaimes, KF, Salvatori, AS, Rhodes, CJ, and Corbett, JA. 2010. IL-1 induces nitric oxide dependent activation of AMPK to drive an anti-apoptotic recovery response in β-cells. J. Biol. Chem. 285:3191-200, PMID: 19933272. |
94. Freudenburg, W, Buller, RML, and Corbett, JA. 2010. Src Family Kinase Participates in the Regulation of Encephalomyocarditis Virus-Induced Cyclooxygenase-2 Expression by Macrophages. J. Gen. Virol. 91: 2278-2285, PMID: 20505008. |
95. Heyduk, E, Moxley, MM, Salvatori, A, Corbett, JA and Heyduk, T. 2010. Homogenous insulin and C-peptide sensors for rapid assessment of islet function. Diabetes, 10: 2360-65, PMID: 20622164. |
96. Lim, J-D, Sergey V. Antipenko, SV, Anderson, JM, Stephen, BR, Bryant SMJ, Yancey, BD Hughes, KJ, Cui, W, Thompson, JA, Corbett, JA and Jun, H-W. 2010 Enhanced rat islet function and survival in vitro a biomimetic self-assembled nanomatrix gel. Tissue Eng Part A. 17(3-4):399-406, PMID: 20807014. |
97. Hughes, KJ, Meares, G, Hansen, PA, and Corbett, JA. 2011. FoxO1 and SIRT1 regulate β-cell responses to nitric oxide. J. Biol. Chem. 286: 8338-8348, PMID: 21196578. |
98. Lim, D-J, Antipenko, SV, Hadley, NT, Hwang, P, Vines, JB, Corbett, JA, and Ho-Wook, J. 2011. Laminin-1 derived cell-adhesive ligands attached to biomimetic self-assembled peptide amphiphile nanomatrix enhance MIN6 β-cell function. Acta Biomaterials (in press), PMID: 20807014. |
99. Meares, G.P, Hughes, KJ, and Corbett, JA. 2010. IRE1-dependent activation of AMPK in response to nitric oxide. MCB. Submitted, PMID: 21896783. |
100. Kerr, SW, Jiang, H, Sellatti, R, McCroy, MA, Jones, NR, Ramos, TN, Madwed, JB, Nagy, TR, Corbett, JA, and Szalzi, AJ. 2010. Pleiotropic effects of C-reactive protein gene deletion. Submitted to Cell Metabolism. |
101. Freudenburg, W, Salvatori, AS, Buller, RML, Corbett, JA, and Skowyra, D. 2010. IFN- induces an accumulation of immunoproteasome in pancreatic -cells. Submitted to JI. |
102. Christsmann, B, Moran, JM, Buller, RM, and Corbett, JA. 2010. CCR5 a novel cell surface signaling receptor for EMCV and dsRNA. Submitted to Am. J. Pathol. |
103. Bai, X, Yan, Y, Canfield, S, Muravyeva, MY, Kikuchi, C, Corbett, JA, and Bosnjak, ZJ. 2011. Ketamine induces apoptosis in human neurons differentiated from embryonic stem cells via reactive oxygen species. Submitted to Anesthesiology. |
104. Waheed, A, Von Figura, G, Moxley MA, Corbett, JA, and Sly, WS. 2009. Chemiluminescence signal of luminal at alkaline pH is strong and stable. Submitted to Biotechniques. |
Books, Chapters, and Reviews |
1. Turk, J, Wang, JL, Corbett, JA, Ramanadham, SR, Wolf, BA, Easom, RA, and McDaniel, ML. 1991. Secretagogue-Induced Diacylglycerol Accumulation and Protein Kinase C Activation in Beta Cell Function. in Diabetes; pp. 161-164, (Rifxin, H, Colwell, JA and Taylor, SI, eds), Elsevier Science Publishing, Amsterdam. |
2. Corbett, JA, Lancaster Jr., JR, Sweetland, MA, and McDaniel, ML. 1992. Iron-dithiol-dinitrosyl Complex Formation Detected by Electron Paramagnetic Resonance Spectroscopy in IL-1 Treated Islets of Langerhans. in The Biology of Nitric Oxide Part 2. (Moncada, S, Marletta, MA, Hibbs Jr., JB, and Higgs, EA eds), Portland Press Ltd, London. |
3. McDaniel, ML, Kwon, G, and Corbett, JA. 1994. Nitric Oxide Production by Human Islets of Langerhans. in Frontiers of Pancreatic -cell Research. pp. 567-574, (Flatt, PR. ed). |
4. Corbett, JA, Kwon, G, Hill, JR, and McDaniel, ML. 1995. Nitric Oxide Mediates Cytokine-induced Islet Destruction. in The Diabetes Annual 9, pp. 265-294, (SM Marshall, PD Home, and RA Rizza, eds.), Elsevier Science B. V., Amsterdam, The Netherlands. |
5. Corbett, JA, Kwon, G, and McDaniel, ML. 1995. Role of Nitric Oxide in -cell Destruction. in Diabetes 1994, pp. 36-46, (S Baba and T. Kaneko, eds), Elsevier Science B. V., Amsterdam, The Netherlands. |
6. Corbett, JA, and McDaniel, ML. 1996. Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes. Methods: A Companion to Methods in Enzymology 10, 21-30. |
7. Corbett, JA, and McDaniel ML. 1996. Selective Inhibition of iNOS by Aminoguanidine. Methods Enzymol. 268, 398-408. |
8. Corbett, JA, and McDaniel, ML. 1996. Role of Nitric Oxide in Diabetes. in The Biological Chemistry of Nitric Oxide (Lancaster Jr., JR. ed), Academic Press, San Diego, CA, pp. 177-217. |
9. McDaniel, ML, Corbett, JA, Kwon, G, and Hill, JR. 1997. A Role for Nitric Oxide and Other Inflammatory Mediators in Cytokine-induced Pancreatic -cell Dysfunction and Destruction. Adv. Exp. Med. Biol. 426, 313-319. |
10. McDaniel, ML, Kwon, G, Hill, JR, Marshall, CA, and Corbett, JA. 1996. Cytokines and Nitric Oxide in Islet Inflammation and Diabetes. Proc. Soc. Exper. Biol. and Med. 211, 24-32. |
11. Corbett, JA., Serup, P., Bonner-Weir, S., and Nielsen, JH. 1997. Beta-cell ontogeny: Growth and Death. Diabetalogia 40, B27-B32. |
12. Heitmeier, MR, Corbett, JA. 1999. Cytotoxic Role of Nitric Oxide in Diabetes. in Nitric Oxide (Ignarro, L. ed.) Academic Press, San Diego, CA. |
13. Corbett, JA, 2001. K cells: a novel target for insulin gene therapy for the prevention of diabetes. Trends: Endo. Metabol. 12, 140-141. |
14. Kelly, CB, Blair, LA, Corbett, JA, and Scarim, AL. 2003. Isolation of Islets of Langerhans from Rodent Pancreas. in Methods in Molecular Medicine. V83. Diabetes Mellitus: Methods and Protocols, pp 3-14, (Sabire Ozacan, volume ed. Walker, JM series ed.). Humana Press Inc., Totowa, New Jersey. |
15. Steer, SA, and Corbett, JA. 2003. Regulation of COX-2 expression by virus infection. Viral Immunol. 16, 447-460. |
16. Hansen, PA, and Corbett, JA. 2005. Incretin hormones and insulin sensitivity. Trends: Endo. Metabol. 16, 135-136. |
17. Moran, JM, Buller, RML, and Corbett, JA. 2005. PKR-independent antiviral pathways activated in response to virus infection. Cell Science Reviews. 2, 108-131. |
18. 18, Corbett, JA. 2006. Insulin biosynthesis: the IREny of it all. Cell Metabolism 4, 1-2. |
19. Gusdon, A., Corbett, JA, and Mathews, CE. 2006. Type 1 diabetes: Islet inflammation- the contribution of cytokines and beta cells. Drug Discovery Today: Dis. Mech. 3, 367-372. |
20. Corbett, JA and Mathews, CE. 2006. Metabolic disorders and inflammation. (Editorial). Drug Discovery Today: Dis. Mech. 3, 365-66. |
21. Waheed, A, Hansen, PA, and Corbett, JA. 2007. Chemically chaperoning the actions of insulin. Trends: Endo. Metabol. 18, 1-3. |
22. Bensch, KG, deGraaf, W, Hansen, PA, Zassenhaus, HP, and Corbett, JA. 2007. A transgenic model to study the pathogenesis of somatic mtDNA mutation. Diabetes, Obesity and Metabolism. Sup 2: 74-80. |
23. Corbett, JA. 2008. Thioredoxin interacting protein is killing my -cells! Diabetes. 57: 797-789. |
