CURRICULUM VITAE
Kenichiro Taniguchi PhD
Kenichiro Taniguchi PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
2002 - 2006 B.S., University of Minnesota - Twin Cities, Minneapolis, MN |
2007 - 2012 Ph.D., University of Virginia School of Medicine, Charlottesville, VA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2012 - 2017 Postdoctoral Fellow, Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI |
2017 - 2019 Research Investigator, Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI |
FACULTY APPOINTMENTS: |
2019 - Present Assistant Professor, Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
2019 - Present Assistant Professor, Pediatrics, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
2017 Bradley M. Patten Award for Excellence in Postdoctoral Research, University of Michigan Medical School |
2020 MCW Outstanding Graduate School Educator 2019-2020, Medical College of Wisconsin |
2021 MCW Outstanding Graduate School Educator 2020-2021, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
Society for Developmental Biology (Member) |
Society for the Study of Reproduction (member) |
International Society for Stem Cell Research (Member) |
American Society for Cell Biology (Member) |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2022 - Present Member, Public Affairs Committee, Society for the Study of Reproduction |
07/2023 Co-Chair/Moderator, Society for Developmental Biology 82nd Annual Meeting: Stem Cells and Regeneration Session |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Modeling peri-implantation human embryogenesis using human pluripotent stem cells, Medical College of Wisconsin, Milwaukee, WI, 10/08/2019 |
Research Deconstruction: Modeling peri-implantation human embryogenesis using human pluripotent stem cells, Research Deconstruction Program, Ripon College, Ripon, WI, 03/20/2023 - 04/21/2023 |
Regional |
Modeling peri-implantation human embryogenesis using human pluripotent stem cells, University of Minnesota - Developmental Biology Center, Minneapolis, MN, 11/18/2016 |
Modeling peri-implantation human embryogenesis using human pluripotent stem cells, Northern Illinois University, Dekalb, IL, 02/21/2018 |
Employing stem cell-derived mini-organs to study human developmental biology and disease, University of Dubuque, Dubuque, IA, 03/19/2021 |
National |
Modeling peri-implantation human embryogenesis using human pluripotent stem cells, University of Colorado - Boulder, Boulder, CO, 02/15/2018 |
Overview of Stem Cells and Temporally resolved early BMP-driven transcriptional cascade during human amnion specification, Frontiers in Reproduction: Molecular and Cellular Concepts and Applications, Marine Biological Laboratory, Woods Hole, MA, 05/15/2023 |
International |
Modeling peri-implantation human embryogenesis using human pluripotent stem cells, Kyoto University - Center for iPS Cell Research and Application (CiRA), Kyoto, Japan, 12/22/2016 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Regional |
An apicosome initiates self-organizing morphogenesis in human pluripotent stem cells, Midwest Society for Developmental Biology Regional Meeting 2016, Ann Arbor, MI, 10/27/2016 |
The small GTPase RAB35 coordinates epithelial polarization and endocytosis in a human model of epiblast formation, poster presentation by Anusha Rengarajan, Midwest Society for Developmental Biology Regional Meeting 2022, Madison, WI, 11/12/2022 |
Novel 3D Culture System to Examine BMP- Dependent Human Amniogenesis, oral presention by Nikola Sekulovski, Midwest Society for Developmental Biology Regional Meeting 2022, Madison, WI, 11/12/2022 |
The AP-1 clathrin adaptor protein complex coordinates human cortical tissue morphogenesis and neurogenesis, poster presentation by Amber Carleton, Midwest Society for Developmental Biology Regional Meeting 2022, Madison, WI, 11/12/2022 |
National |
An apicosome initiates self-organizing morphogenesis in human pluripotent stem cells, Society for Developmental Biology 76th Annual Meeting, Minneapolis, MN, 07/14/2017 |
Apical Morphogenesis in a Human Epiblast Model is Driven by AP-1 Clathrin Adaptor Complex- Dependent Trafficking Machinery, oral presentation by Amber Carleton, 54th Society for the Study of Reproduction Annual Meeting, St. Louis, MO, 12/16/2021 |
Novel 3D Culture System to Examine BMP- Dependent Human Amniogenesis, oral presention by Nikola Sekulovski, 54th Society for Study of Reproduction Annual Meeting, St. Louis, MO, 12/16/2021 |
Single Cell Transcriptomic Analysis in a Human Model of Amniogenesis, poster presentation, 54th Society for the Study of Reproduction Annual Meeting, St. Louis, MO, 12/17/2021 |
The small GTPase RAB35 coordinates epithelial polarization and endocytosis in a human model of epiblast formation, poster presentation by Anusha Rengarajan, 55th Society for the Study of Reproduction Annual Meeting, Spokane, WA, 07/27/2022 |
Novel 3D Culture System to Examine BMP- Dependent Human Amniogenesis, poster presention by Nikola Sekulovski, 55th Society for the Study of Reproduction Annual Meeting, Spokane, WA, 07/27/2022 |
Apical Morphogenesis in a Human Epiblast Model is Driven by AP-1 Clathrin Adaptor Complex-dependent Trafficking Machinery, oral presentation by Amber Carleton, 55th Society for the Study of Reproduction Annual Meeting, Spokane, WA, 07/27/2022 |
International |
An apicosome initiates self-organizing morphogenesis in human pluripotent stem cells, ISSCR 2016 ANNUAL MEETING, San Francisco, CA, 06/25/2016 |
APEX2 based spatial proteomic analysis of a human pluripotent stem cell derived epiblast-like model, oral presentation by Sicong Wang, ISSCR 2020 ANNUAL MEETING, Virtual, 06/26/2020 |
The small GTPase RAB35 coordinates epithelial polarization and cell survival in a human model of epiblast formation, oral presentation by Anusha Rengarajan, Cell Bio 2022, Washington, D.C., 12/04/2022 |
The AP-1 clathrin adaptor protein complex coordinates human cortical tissue morphogenesis and neurogenesis, poster presentation by Amber Carleton, Cell Bio 2022, Washington, D.C., 12/06/2022 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2020 - Present Cell and Developmental Biology Direct Admissions Evaluation Committee, Cell Biology, Neurobiology and Anatomy |
2021 - Present Interdisciplinary Doctoral Program Mentoring Committee, Institutional |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Graduate Student Education |
2020 Advanced Cell Biology - Epithelial Cell Polarity section |
2021 Developmental and Stem Cell Biology - Modeling Early Human Embryogenesis section |
2021 Professional Development I |
2022 Advanced Cell Biology - Epithelial Cell Polarity section |
2022 Professional Development I |
2023 Developmental and Stem Cell Biology (co-director) - Modeling Early Human Embryogenesis section |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Jenna Wettstein, Medical College of Wisconsin, 2022 - Present |
Graduate Students |
PhD Committees |
Tendai Hunyenyiwa, Medical College of Wisconsin, 2020 - Present |
Olivia Franklin, Medical College of Wisconsin, 2021 - Present |
Priscilla Kyi, Medical College of Wisconsin, 2021 - Present |
Josiah Murray (MSTP), Medical College of Wisconsin, 2023 - Present |
PhD Students Advised |
Amber Carleton, Medical College of Wisconsin, 2020 - Present |
Anusha Rengarajan, Medical College of Wisconsin, 2021 - Present |
Clinical/Research Fellows |
Nikola Sekulovski, Medical College of Wisconsin, 2020 - Present Postdoctoral Training |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
Supriya Jalkar, University of Michigan Medical School, 2012 UROP, Research Mentor |
Deming Chue, University of Michigan Medical School, 2012 - 2014 Research Mentor |
Ryan Townshend, University of Michigan Medical School, 2013 - 2018 UROP, Research Mentor |
Ben Smith, University of Michigan Medical School, 2015 - 2018 Research Mentor |
Dennis Thomas, University of Michigan Medical School, 2015 Research Mentor |
Medical Students |
Andrew Freddo, University of Michigan Medical School, 2012 - 2016 Research Mentor |
Ajay Prakash, University of Michigan Medical School, 2014 Research Mentor |
Graduate Students |
Yue Shao, University of Michigan Medical School, 2015 - 2017 |
Sicong Wang, University of Michigan Medical School, Medical College of Wisconsin, 2017 - 2020 |
COMMUNITY SERVICE ACTIVITIES: |
2012 - 2015 University of Michigan Bioartography Program |
PATENT: |
Development of amnion-like tissue from human pluripotent stem cells, US Patent App. 16/467,154 - This patent was filed for the development of human pluripotent stem cell derived amnion-like tissue described in Shao et al. Nature Materials 2017.
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BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Wang S, Lin CW, Carleton AE, Cortez CL, Johnson C, Taniguchi LE, Sekulovski N, Townshend RF, Basrur V, Nesvizhskii AI, Zou P, Fu J, Gumucio DL, Duncan MC, Taniguchi K. Spatially resolved cell polarity proteomics of a human epiblast model. Sci Adv. 2021 Apr;7(17). PMCID: PMC8064645 |
2. Townshend RF, Shao Y, Wang S, Cortez CL, Esfahani SN, Spence JR, O'Shea KS, Fu J, Gumucio DL, Taniguchi K. Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells. Front Cell Dev Biol. 2020;8:588941. PMCID: PMC7593581 |
3. Taniguchi K, Heemskerk I, Gumucio DL. Opening the black box: Stem cell-based modeling of human post-implantation development. J Cell Biol. 2019 Feb 04;218(2):410-421. PMCID: PMC6363460 |
4. Wotton D, Taniguchi K. Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly. Am J Med Genet C Semin Med Genet. 2018 Jun;178(2):128-139. PMCID: PMC6125192 |
5. Taniguchi K, Shao Y, Townshend RF, Cortez CL, Harris CE, Meshinchi S, Kalantry S, Fu J, O'Shea KS, Gumucio DL. An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells. J Cell Biol. 2017 Dec 04;216(12):3981-3990. PMCID: PMC5716285 |
6. Shao Y, Taniguchi K, Townshend RF, Miki T, Gumucio DL, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017 Aug 08;8(1):208. PMCID: PMC5547056 |
7. Shao Y, Taniguchi K, Gurdziel K, Townshend RF, Xue X, Yong KMA, Sang J, Spence JR, Gumucio DL, Fu J. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017 Apr;16(4):419-425. PMCID: PMC5374007 |
8. Anderson AE, Taniguchi K, Hao Y, Melhuish TA, Shah A, Turner SD, Sutherland AE, Wotton D. Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l. Mol Cell Biol. 2017 Mar 01;37(5). PMCID: PMC5311242 |
9. Taniguchi K, Anderson AE, Melhuish TA, Carlton AL, Manukyan A, Sutherland AE, Wotton D. Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning. Eur J Hum Genet. 2017 Feb;25(2):208-215. PMCID: PMC5255961 |
10. Freddo AM, Shoffner SK, Shao Y, Taniguchi K, Grosse AS, Guysinger MN, Wang S, Rudraraju S, Margolis B, Garikipati K, Schnell S, Gumucio DL. Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding. Integr Biol (Camb). 2016 Sep 12;8(9):918-28. PMCID: PMC5021607 |
11. Melhuish TA, Taniguchi K, Wotton D. Tgif1 and Tgif2 Regulate Axial Patterning in Mouse. PLoS One. 2016;11(5):e0155837. PMCID: PMC4871493 |
12. Taniguchi K, Shao Y, Townshend RF, Tsai YH, DeLong CJ, Lopez SA, Gayen S, Freddo AM, Chue DJ, Thomas DJ, Spence JR, Margolis B, Kalantry S, Fu J, O'Shea KS, Gumucio DL. Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells. Stem Cell Reports. 2015 Dec 08;5(6):954-962. PMCID: PMC4682207 |
13. Taniguchi K, Anderson AE, Sutherland AE, Wotton D. Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway. PLoS Genet. 2012;8(2):e1002524. PMCID: PMC3285584 |
14. Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010 Jan;137(2):249-59. PMCID: PMC2799159 |
15. Tang X, Taniguchi K, Kofuji P. Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis. Glia. 2009 Dec;57(16):1706-15. PMCID: PMC2764821 |
16. Schmidt TM, Taniguchi K, Kofuji P. Intrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse development. J Neurophysiol. 2008 Jul;100(1):371-84. PMCID: PMC2493479 |
17. Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H. Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development. 2005 Jun;132(11):2535-46. |
18. Carleton AE, Duncan MC, Taniguchi K. Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst. Semin Cell Dev Biol. 2022 Nov;131:117-123. PMCID: PMC9529837 |
19. Hamed MM, Taniguchi K, Duncan MC. Monitoring Effects of Membrane Traffic Via Changes in Cell Polarity and Morphogenesis in Three-Dimensional Human Pluripotent Stem Cell Cysts. Methods Mol Biol. 2023;2557:83-98. PMCID: PMC10276343 |
