CURRICULUM VITAE
Kyungsoo Shin PhD
Kyungsoo Shin PhD
Assistant Professor
Department of Biophysics
Department of Biophysics
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-4048 |
Email: kshin@mcw.edu |
EDUCATION: |
09/2007 - 05/2011 BS, Dalhousie University, Halifax, NS |
09/2011 - 08/2017 PhD, Dalhousie University, Halifax, NS |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/2017 - 09/2022 Postdoctoral Fellow, Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA |
AWARDS AND HONORS: |
09/2007 Dalhousie University Residence Award |
09/2007 Hector McInnes Memorial Scholarship |
09/2007 Homer Fund Scholarship |
09/2007 Lockward Memorial Scholarship |
05/2008 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award |
09/2008 G H Campbell Memorial Scholarship |
05/2009 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award |
09/2009 Dalhousie University Residence Award |
09/2009 Dalhousie University Entrance Renewal Scholarship |
05/2010 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award |
09/2010 Dalhousie University Entrance Renewal Scholarship |
09/2010 Orange Scholars Scholarship |
09/2012 Natural Sciences and Engineering Research Council of Canada Graduate Scholarship (NSERC)-MSc |
09/2014 Dalhousie University President's Award |
09/2014 Izaak Walton Killam Predoctoral Scholarship |
09/2014 Natural Sciences and Engineering Research Council of Canada Graduate Scholarship (NSERC)-PhD |
08/2015 Dalhousie Medical Research Foundation Kathryn A. Weldon Travel Award |
09/2015 IWK Health Centre Conference Presentation Travel Award |
04/2016 Dept. Obs/Gyn Research Day Graduate Student Platform Presentation Prize |
05/2016 Canadian Society for Chemistry Conference Graduate Platform Award |
07/2016 Regulatory Peptide (REGPEP) 2016 Conference Travel Award |
07/2016 Tang Prize Foundation Travel Award |
10/2016 MOOT NMR Mini Symposium Travel Award |
09/2017 Beth Gourley Travel Award for Research Excellence |
06/2018 Canadian Institute of Health Research (CIHR) Postdoctoral Fellowship |
02/2019 The Biophysical Society Annual Meeting Travel Award |
08/2020 Southern California Users of NMR Meeting Poster Prize |
10/2020 SBP Medical Discovery Institute Fishman Fund Fellowship |
03/2024 MCW Office of Research’s 2024 Research Day – Top-scoring Faculty Poster , Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
01/2013 - 01/2017 Canadian Society for Chemistry (Member) |
01/2015 - 01/2018 Canadian Society of Molecular Biology (Member) |
01/2015 - 01/2016 Endocrine Society (Member) |
10/2017 - 10/2023 Biophysical Society (Member) |
01/2022 - 01/2023 Association for Research in Vision and Ophthalmology (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
02/2024 - Present Biochemistry |
09/2024 - Present Archives of Oral Biology |
12/2024 - Present Biochemistry and Cell Biology |
12/2024 - Present Journal of American Chemical Society |
01/2025 - Present Communications Biology |
01/2025 - Present Nature Communications |
01/2025 - Present JACS Au |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Shin K, Biomolecular interactions at the cell surface: My journey from helpful hormones to the deadly plague., Biochemistry & Molecular Biology Patrick Prize Presentation, Dalhousie University, Halifax, NS, Canada, 01/09/2019 |
Shin K, Structural determination of the Vitronectin C-terminal domain: the hub for molecular interplay from plague bacteria to its potential role in macular degeneration, Sanford Burnham Medical Discovery Institute, San Diego, CA, USA, 09/16/2020 |
Shin K, Deciphering the molecular interplay of vitronectin in age-related macular degeneration, Sanford Burnham Medical Discovery Institute, San Diego, CA, USA, 09/22/2021 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, 19th International Symposium on Regulatory Peptides, Copenhagen, Denmark, 08/22/2012 - 08/25/2012 |
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Elucidating the role of preferential membrane-association in regulation of proprotein processing, 21st International Symposium on Regulatory Peptides, Rouen, France, 07/11/2016 - 07/15/2016 |
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Testing for membrane-modulated proprotein processing, 16th International Conference of Biochemistry and Molecular Biology, Vancouver, BC, Canada, 07/17/2016 - 07/21/2016 |
National |
Shin K, Pandey A, Anini Y, Rainey JK, Proapelin activation into apelin-13 by proprotein convertase subtilisin kexin-3, 25th MOOT NMR symposium, Quebec City, QC, Canada, 10/27/2012 - 10/28/2012 |
Shin K, Pandey A, Anini Y, Rainey JK, The bioactive peptide apelin is activated to a specific isoform by proprotein convertase subtilisin kexin-3, 96th Canadian Chemistry Conference and Exhibition, Quebec City, QC, Canada, 05/26/2013 - 05/30/2013 |
Shin K, Chapman NA, Pandey A, Dupré D, Anini Y, Rainey JK, Structural characterization of proapelin processing, 26th MOOT NMR symposium, Kingston, ON, Canada, 10/24/2013 - 10/27/2013 |
Shin K, Pandey A, Sarker M, Anini Y, and Rainey JK, Proapelin structure and dynamics as a route to understanding its processing mechanism, Gordon Research Conference (GRC) on Protein Processing Trafficking & Secretion, New London, NH, USA, 07/19/2014 - 07/25/2014 |
Shin K, Pandey A, Sarker M, Huang SK, Anini Y, Rainey JK, Testing the potential involvement of lipid membranes in proapelin processing, 27th MOOT NMR symposium, Montreal, QC, Canada, 10/17/2014 - 10/19/2014 |
Shin K and Anini Y, Role of TNF-α in the altered ghrelin secretion in obesity, 97th Annual Meeting of the Endocrine Society, San Diego, CA, USA, 03/05/2015 - 03/08/2015 |
Shin K, Sarker M, Pandey A, Chapman NA, Huang SK, Anini Y, Rainey JK, Testing the potential for membrane catalyzed modification of proprotein processing specificity, Canadian Society of Molecular Biology 58th Annual Meeting, Halifax, NS, Canada, 06/14/2015 - 06/17/2015 |
Shin K, Sarker M, Huang SK, Pandey A, Anini Y, Rainey JK, Probing lipid involvement in proprotein processing: The story of proapelin and PCSKs, 28th MOOT NMR symposium, Hamilton, ON, Canada, 10/24/2015 - 10/25/2015 |
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Elucidating membrane-induced modulation of proprotein conformation and dynamics, 99th Canadian Chemistry Conference and Exhibition, Halifax, NS, Canada, 06/05/2016 - 06/09/2016 |
Shin K, Sarker M, Huang SK, Rainey JK, Isoform-dependent membrane binding preferences differ between apelin and apela cognate peptide ligands for the same GPCR, 29th MOOT NMR symposium, Charlottetown, PEI, Canada, 09/30/2016 - 10/02/2016 |
Shin K, Sarker M, Huang SK, Rainey JK, Apelin and apela ligands for the same GPCR differ in their isoform- and headgroup-dependent micelle interaction, Biophysical Society 2017 Annual Meeting, New Orleans, LA, USA, 02/11/2017 - 02/15/2017 |
Shin K, Sarker M, Huang SK, Kenward C, Rainey JK, Distinct differences in membrane interaction for two peptide ligands for the same GPCR, 3rd Biophysical Society of Canada Annual Meeting, Montreal, QC, Canada, 05/24/2017 - 05/27/2017 |
Shin K, Lechtenberg BC, Fujimoto LM, Meneghini L, Singh C, Yao Y, Tien Y, Marassi FM, Elucidating the structure of vitronectin mediator of Y. pestis pathogenesis, Biophysical Society 2019 Annual Meeting, Baltimore, MD, USA, 03/02/2019 - 03/2019 |
Shin K, Fujimoto LM, Kent JE, Bobkov AA, Zeng FY, Pass I, Marassi FM, Role of vitronectin in the formation of lipid-protein aggregates in age-related macular degeneration, Biophysical Society 2020 Annual Meeting, San Diego, CA, USA, 02/15/2020 - 02/19/2020 |
Shin K, Fujimoto LM, Kent JE, Aleshin A, Tian Y, Bobkov AA, Im W, Marassi FM, Determining vitronectin's role in forming the hallmark of age-related macular degeneration, Biophysical Society 2021 Annual Meeting, Virtual Online, 02/22/2021 - 02/26/2021 |
Shin K, Fujimoto LM, Kent JE, Aleshin A, Tian Y, Bobkov AA, Im W, Marassi FM, Coordination of age-related macular degeneration pathogenesis by vitronectin, Biophysical Society 2022 Annual Meeting, San Francisco, CA, USA, 02/19/2022 - 02/23/2022 |
Shin K, Kent J, Thompson R, Marassi FM, Mechanistic insight into the role of vitronectin in age-related macular degeneration, 2022 ARVO Annual Meeting, Denver, CO, USA, 04/30/2022 - 05/04/2022 |
Shin K, Kent J, Aleshin A, Tian Y, Fujimoto LM, Singh C, and Marassi FM, Dissecting the conformation-dependent substrate specificity of vitronectin, 64th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, USA, 04/16/2023 - 04/20/2023 |
Shin K, Kent J, Gopinath T, Akerman BE, Kraft A, Panigrahi R, Wood N, Debelouchina G, and Marassi FM, Solid-state NMR in native bacterial samples: characterization of the host-pathogen interactions, 65th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, USA, 04/07/2024 - 04/11/2024 |
Regional |
Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM, Structural insight into vitronectin's role in age-related macular degeneration, 2020 Southern California Users of NMR Meeting, Virtual Online, 08/29/2020 |
Local |
Shin K, Anini Y, Rainey JK, Role of Apelin in Adipose Tissue, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/08/2011 |
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/06/2012 |
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, Dalhousie IHRTP Graduate Student Research Day, Halifax, NS, Canada, 05/15/2012 |
Shin K, Pandey A, Anini Y, Rainey JK, Apelin is activated by proprotein convertase subtilisin kexin 3, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/05/2013 |
Shin K, Anini Y, Postprandial ghrelin suppression is impaired in obesity: role of insulin resistance and inflammatory cytokines, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/04/2014 |
Shin K, Sarker M, Pandey A, Chapman NA, Huang SK, Anini Y, Rainey JK, Probing the membrane involvement in PCSK-mediated proprotein processing, Dalhousie IHRTP Graduate Student Research Day, Halifax, NS, Canada, 05/14/2015 |
Shin K, Sarker M, Huang SK, Rainey JK, Anini Y, Characterization of apela and apelin: hormones important for heart development and function, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/29/2016 |
Shin K, Chapman NA, Sarker M, Weatherbee-Martin N, Kenward C, Huang SK, Dupré D, Anini Y, Rainey JK, Features of apelin isoforms involved in GPCR recognition vs. modulation of activity, Dalhousie PREP Graduate Student Research Day, Halifax, NS, Canada, 05/17/2016 |
Shin K, Fujimoto LM, Meneghini L, Singh C, Yao Y, Tien Y, Marassi FM, Structural determination of vitronectin the serum protein involved in Y. pestis pathogenesis, 17th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/20/2018 |
Shin K, Lechtenberg BC, Fujimoto LM, Meneghini L, Yao Y, Bartra SS, Plano GV, Marassi FM, Elucidating the structure of vitronectin C-terminal domain and its involvement in Y. pestis pathogenesis, 18th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/19/2019 |
Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM, Deciphering the structural mechanism behind vitronectin's role in age-related macular degeneration, 19th Annual SBP Postdoc Research Symposium, Virtual Online, 09/24/2020 |
Shin K, Kent JE, Aleshin AE, Fujimoto LM, Singh C, Tian Y, Marassi FM, Identifying vitronectin as a coordinator of age-related macular degeneration pathogenesis., 20th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/23/2021 |
Shin K, Panigrahi R, Gopinath T, Kent JE, Tian Y, Aleshin AE, Samimuthu K, Zhu L, and Marassi FM, In Pursuit of Vitronectin Structure to Uncover Its Role in Ectopic Calcification of Age-Related Diseases, Medical College of Wisconsin Office of Research’s 2024 Research Day, Milwaukee, WI, USA, 03/14/2024 |
MCW TEACHING ACTIVITIES: |
Graduate Student Education |
09/2022 - 10/2024 Biophysical Techniques in Biochemistry Capacity (Lecturer) |
EXTRAMURAL TEACHING: |
Graduate Student Education |
11/2021 Sanford Burnham Prebys Medical Discovery Institute, Molecules to Systems Course Capacity (Teaching Assistant) |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Graduate Students |
Students Advised |
06/2023 - Present Alyssa Kraft, Medical College of Wisconsin |
09/2024 - Present Rana Mansour, Medical College of Wisconsin |
Postdoctoral Researchers |
08/2023 - Present Nicholas Wood, Medical College of Wisconsin |
09/2023 - Present Rajlaxmi Panigrahi, Medical College of Wisconsin |
09/2024 - Present Swapna Bera, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
06/2013 - 08/2013 Sammy Jony, IWK Children's Hospital |
06/2021 - 08/2021 Celine Jingyi Cen, Sanford Burnham Prebys Medical Discovery Institute |
08/2022 Jordan S. Min, Sanford Burnham Prebys Medical Discovery Institute |
Undergraduate Students |
05/2013 - 05/2015 Stephanie Pelletier, Dalhousie University |
09/2013 - 12/2013 Ellie Scott, Dalhousie University |
09/2013 - 05/2014 Sophie Hamr, Dalhousie University |
09/2014 - 05/2016 Shuya Kate Huang, Dalhousie University |
05/2015 - 09/2017 Jessica Basta, Dalhousie University |
09/2015 - 05/2016 Calem Kenward, Dalhousie University |
09/2015 - 05/2017 Michael Landsman, Dalhousie University |
Graduate Students |
PhD Students Advised |
09/2018 - 09/2022 James Kent, Sanford Burnham Prebys Medical Discovery Institute |
OTHER MENTORING ACTIVITIES: |
03/2023 - Present Research Associate - Karthika Samimuthu, Medical College of Wisconsin |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Gopinath T, Kraft A, Shin K, Wood NA, Marassi FM. Solid state NMR spectral editing of histidine, arginine and lysine using Hadamard encoding. J Biomol NMR. 2025 Mar;79(1):35-45. |
2. Gopinath T, Kraft A, Shin K, Wood NA, Marassi FM. Solid state NMR spectral editing of histidine, arginine and lysine using Hadamard encoding. bioRxiv. 2024 Jul 24. PMCID: PMC11360888 |
3. Gopinath T, Shin K, Tian Y, Im W, Struppe J, Perrone B, Hassan A, Marassi FM. Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite. J Struct Biol. 2024 Mar;216(1):108061. PMCID: PMC10939839 |
4. Tian Y, Shin K, Aleshin AE, Im W, Marassi FM. Calcium-induced environmental adaptability of the blood protein vitronectin. Biophys J. 2022 Oct 18;121(20):3896-3906. PMCID: PMC9674982 |
5. Kent JE, Fujimoto LM, Shin K, Singh C, Yao Y, Park SH, Opella SJ, Plano GV, Marassi FM. Correlating the Structure and Activity of Y. pestis Ail in a Bacterial Cell Envelope. Biophys J. 2021 Feb 02;120(3):453-462. PMCID: PMC7895992 |
6. Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM. Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation. Proc Natl Acad Sci U S A. 2020 Aug 04;117(31):18504-18510. PMCID: PMC7414086 |
7. Shin K, Lechtenberg BC, Fujimoto LM, Yao Y, Bartra SS, Plano GV, Marassi FM. Structure of human Vitronectin C-terminal domain and interaction with <i>Yersinia pestis</i> outer membrane protein Ail. Sci Adv. 2019 Sep;5(9):eaax5068. PMCID: PMC6739113 |
8. Shin K, Landsman M, Pelletier S, Alamri BN, Anini Y, Rainey JK. Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases. Amino Acids. 2019 Mar;51(3):395-405. PMCID: PMC7101949 |
9. Kenward C, Shin K, Rainey JK. Mixed Fluorotryptophan Substitutions at the Same Residue Expand the Versatility of <sup>19</sup> F Protein NMR Spectroscopy. Chemistry. 2018 Mar 07;24(14):3391-3396. |
10. Shin K, Sarker M, Huang SK, Rainey JK. Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup. Sci Rep. 2017 Nov 13;7(1):15433. PMCID: PMC5684411 |
11. Dutta D, Shin K, Rainey JK, Fliegel L. Transmembrane Segment XI of the Na<sup>+</sup>/H<sup>+</sup> Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore. Sci Rep. 2017 Oct 16;7(1):12793. PMCID: PMC5643542 |
12. Shin K, Chapman NA, Sarker M, Kenward C, Huang SK, Weatherbee-Martin N, Pandey A, Dupré DJ, Rainey JK. Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands. Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1901-1912. PMCID: PMC5770203 |
13. Huang SK, Shin K, Sarker M, Rainey JK. Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics. Biochim Biophys Acta Biomembr. 2017 May;1859(5):767-778. |
14. Read J, Clancy EK, Sarker M, de Antueno R, Langelaan DN, Parmar HB, Shin K, Rainey JK, Duncan R. Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor. PLoS Pathog. 2015 Jun;11(6):e1004962. PMCID: PMC4464655 |
15. Shin K, Pandey A, Liu XQ, Anini Y, Rainey JK. Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity. FEBS Open Bio. 2013;3:328-33. PMCID: PMC3821026 |
16. Wood NA, Gopinath T, Shin K, Marassi FM. <i>In situ</i> NMR reveals a pH sensor motif in an outer membrane protein that drives bacterial vesicle production. bioRxiv. 2025 Jan 24. PMCID: PMC11785132 |
17. Wood NA, Kraft A, Shin K, Gopinath T, Marassi FM. In situ NMR reveals a pH sensor motif in an outer membrane protein that drives bacterial vesicle production. Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2501638122. |
Books, Chapters, and Reviews |
1. Shin K*, Kent JE*, Marassi FM. Membranes, Minerals and Magnets: Application of NMR Spectroscopy to Biological Interfaces. In: Bhunia A, Atreya HS, Sinha N, editors. NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces. London: Royal Society of Chemistry; Aug 2022. p. 496-529. |
2. Shin K, Kenward C, Rainey JK. Apelinergic System Structure and Function. Compr Physiol. 2017 Dec 12;8(1):407-450. PMCID: PMC5821487 |
3. Pandey A, Shin K, Patterson RE, Liu XQ, Rainey JK. Current strategies for protein production and purification enabling membrane protein structural biology. Biochem Cell Biol. 2016 Dec;94(6):507-527. PMCID: PMC5752365 |
4. Alamri BN, Shin K, Chappe V, Anini Y. The role of ghrelin in the regulation of glucose homeostasis. Horm Mol Biol Clin Investig. 2016 Apr 01;26(1):3-11. |
