Medical College of Wisconsin
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CURRICULUM VITAE

Kyungsoo Shin PhD
Assistant Professor
Department of Biophysics

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/2007 - 05/2011 BS, Dalhousie University, Halifax, NS
09/2011 - 08/2017 PhD, Dalhousie University, Halifax, NS

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
10/2017 - 09/2022 Postdoctoral Fellow, Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

AWARDS AND HONORS:
09/2007 Dalhousie University Residence Award
09/2007 Hector McInnes Memorial Scholarship
09/2007 Homer Fund Scholarship
09/2007 Lockward Memorial Scholarship
05/2008 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award
09/2008 G H Campbell Memorial Scholarship
05/2009 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award
09/2009 Dalhousie University Residence Award
09/2009 Dalhousie University Entrance Renewal Scholarship
05/2010 Natural Sciences and Engineering Research Council (NSERC)-Undergraduate Student Research Award
09/2010 Dalhousie University Entrance Renewal Scholarship
09/2010 Orange Scholars Scholarship
09/2012 Natural Sciences and Engineering Research Council of Canada Graduate Scholarship (NSERC)-MSc
09/2014 Dalhousie University President's Award
09/2014 Natural Sciences and Engineering Research Council of Canada Graduate Scholarship (NSERC)-PhD
09/2014 Izaak Walton Killam Predoctoral Scholarship
08/2015 Dalhousie Medical Research Foundation Kathryn A. Weldon Travel Award
09/2015 IWK Health Centre Conference Presentation Travel Award
04/2016 Dept. Obs/Gyn Research Day Graduate Student Platform Presentation Prize
05/2016 Canadian Society for Chemistry Conference Graduate Platform Award
07/2016 Regulatory Peptide (REGPEP) 2016 Conference Travel Award
07/2016 Tang Prize Foundation Travel Award
10/2016 MOOT NMR Mini Symposium Travel Award
09/2017 Beth Gourley Travel Award for Research Excellence
06/2018 Canadian Institute of Health Research (CIHR) Postdoctoral Fellowship
02/2019 The Biophysical Society Annual Meeting Travel Award
08/2020 Southern California Users of NMR Meeting Poster Prize
10/2020 SBP Medical Discovery Institute Fishman Fund Fellowship

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
10/2019 - Present The Biophysical Society Member
05/2022 - Present Association for Research in Vision and Ophthalmology Member

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Role of Vitronectin in age-related macular degeneration
Source:
Fishman Fund Fellowship; Sanford Burnham Prebys Medical Discovery Institute
Role:
Postdoctoral Research Fellow
Dates:
10/01/2020 - 10/31/2022
Direct Funds:
$125,000 (total for all years)
  
Prior
Peer Review
Title:
Elucidating the interaction between Ail and Vitronectin at the atomic level to determine the mechanism of Yersinia pestis pathogenesis.
Source:
Canadian Institute of Health Research Fellowship
Role:
Postdoctoral Research Fellow
Dates:
06/01/2018 - 06/31/2021
Direct Funds:
$150,000 (total for all years)
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Shin K, Biomolecular interactions at the cell surface: My journey from helpful hormones to the deadly plague., Biochemistry & Molecular Biology Patrick Prize Presentation, Dalhousie University, Halifax, NS, Canada, 01/09/2019
Shin K, Structural determination of the Vitronectin C-terminal domain: the hub for molecular interplay from plague bacteria to its potential role in macular degeneration, Sanford Burnham Medical Discovery Institute, San Diego, CA, USA, 09/16/2020
Shin K, Deciphering the molecular interplay of vitronectin in age-related macular degeneration, Sanford Burnham Medical Discovery Institute, San Diego, CA, USA, 09/22/2021
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Shin K, Anini Y, Rainey JK, Role of Apelin in Adipose Tissue, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/08/2011
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/06/2012
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, Dalhousie IHRTP Graduate Student Research Day, Halifax, NS, Canada, 05/15/2012
Shin K, Pandey A, Anini Y, Rainey JK, Apelin is activated by proprotein convertase subtilisin kexin 3, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/05/2013
Shin K, Anini Y, Postprandial ghrelin suppression is impaired in obesity: role of insulin resistance and inflammatory cytokines, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/04/2014
Shin K, Sarker M, Pandey A, Chapman NA, Huang SK, Anini Y, Rainey JK, Probing the membrane involvement in PCSK-mediated proprotein processing, Dalhousie IHRTP Graduate Student Research Day, Halifax, NS, Canada, 05/14/2015
Shin K, Sarker M, Huang SK, Rainey JK, Anini Y, Characterization of apela and apelin: hormones important for heart development and function, IWK Obstetrics and Gynecology Research Day, Halifax, NS, Canada, 04/29/2016
Shin K, Chapman NA, Sarker M, Weatherbee-Martin N, Kenward C, Huang SK, Dupré D, Anini Y, Rainey JK, Features of apelin isoforms involved in GPCR recognition vs. modulation of activity, Dalhousie PREP Graduate Student Research Day, Halifax, NS, Canada, 05/17/2016
Shin K, Fujimoto LM, Meneghini L, Singh C, Yao Y, Tien Y, Marassi FM, Structural determination of vitronectin the serum protein involved in Y. pestis pathogenesis, 17th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/20/2018
Shin K, Lechtenberg BC, Fujimoto LM, Meneghini L, Yao Y, Bartra SS, Plano GV, Marassi FM, Elucidating the structure of vitronectin C-terminal domain and its involvement in Y. pestis pathogenesis, 18th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/19/2019
Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM, Deciphering the structural mechanism behind vitronectin's role in age-related macular degeneration, 19th Annual SBP Postdoc Research Symposium, Virtual Online, 09/24/2020
Shin K, Kent JE, Aleshin AE, Fujimoto LM, Singh C, Tian Y, Marassi FM, Identifying vitronectin as a coordinator of age-related macular degeneration pathogenesis., 20th Annual SBP Postdoc Research Symposium, La Jolla, CA, USA, 09/23/2021
 
Regional
Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM, Structural insight into vitronectin's role in age-related macular degeneration, 2020 Southern California Users of NMR Meeting, Virtual Online, 08/29/2020
 
National
Shin K, Pandey A, Anini Y, Rainey JK, Proapelin activation into apelin-13 by proprotein convertase subtilisin kexin-3, 25th MOOT NMR symposium, Quebec City, QC, Canada, 10/27/2012 - 10/28/2012
Shin K, Pandey A, Anini Y, Rainey JK, The bioactive peptide apelin is activated to a specific isoform by proprotein convertase subtilisin kexin-3, 96th Canadian Chemistry Conference and Exhibition, Quebec City, QC, Canada, 05/26/2013 - 05/30/2013
Shin K, Chapman NA, Pandey A, Dupré D, Anini Y, Rainey JK, Structural characterization of proapelin processing, 26th MOOT NMR symposium, Kingston, ON, Canada, 10/24/2013 - 10/27/2013
Shin K, Pandey A, Sarker M, Anini Y, and Rainey JK, Proapelin structure and dynamics as a route to understanding its processing mechanism, Gordon Research Conference (GRC) on Protein Processing Trafficking & Secretion, New London, NH, USA, 07/19/2014 - 07/25/2014
Shin K, Pandey A, Sarker M, Huang SK, Anini Y, Rainey JK, Testing the potential involvement of lipid membranes in proapelin processing, 27th MOOT NMR symposium, Montreal, QC, Canada, 10/17/2014 - 10/19/2014
Shin K and Anini Y, Role of TNF-α in the altered ghrelin secretion in obesity, 97th Annual Meeting of the Endocrine Society, San Diego, CA, USA, 03/05/2015 - 03/08/2015
Shin K, Sarker M, Pandey A, Chapman NA, Huang SK, Anini Y, Rainey JK, Testing the potential for membrane catalyzed modification of proprotein processing specificity, Canadian Society of Molecular Biology 58th Annual Meeting, Halifax, NS, Canada, 06/14/2015 - 06/17/2015
Shin K, Sarker M, Huang SK, Pandey A, Anini Y, Rainey JK, Probing lipid involvement in proprotein processing: The story of proapelin and PCSKs, 28th MOOT NMR symposium, Hamilton, ON, Canada, 10/24/2015 - 10/25/2015
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Elucidating membrane-induced modulation of proprotein conformation and dynamics, 99th Canadian Chemistry Conference and Exhibition, Halifax, NS, Canada, 06/05/2016 - 06/09/2016
Shin K, Sarker M, Huang SK, Rainey JK, Isoform-dependent membrane binding preferences differ between apelin and apela cognate peptide ligands for the same GPCR, 29th MOOT NMR symposium, Charlottetown, PEI, Canada, 09/30/2016 - 10/02/2016
Shin K, Sarker M, Huang SK, Rainey JK, Apelin and apela ligands for the same GPCR differ in their isoform- and headgroup-dependent micelle interaction, Biophysical Society 2017 Annual Meeting, New Orleans, LA, USA, 02/11/2017 - 02/15/2017
Shin K, Sarker M, Huang SK, Kenward C, Rainey JK, Distinct differences in membrane interaction for two peptide ligands for the same GPCR, 3rd Biophysical Society of Canada Annual Meeting, Montreal, QC, Canada, 05/24/2017 - 05/27/2017
Shin K, Lechtenberg BC, Fujimoto LM, Meneghini L, Singh C, Yao Y, Tien Y, Marassi FM, Elucidating the structure of vitronectin mediator of Y. pestis pathogenesis, Biophysical Society 2019 Annual Meeting, Baltimore, MD, USA, 03/02/2019 - 03/2019
Shin K, Fujimoto LM, Kent JE, Bobkov AA, Zeng FY, Pass I, Marassi FM, Role of vitronectin in the formation of lipid-protein aggregates in age-related macular degeneration, Biophysical Society 2020 Annual Meeting, San Diego, CA, USA, 02/15/2020 - 02/19/2020
Shin K, Fujimoto LM, Kent JE, Aleshin A, Tian Y, Bobkov AA, Im W, Marassi FM, Determining vitronectin's role in forming the hallmark of age-related macular degeneration, Biophysical Society 2021 Annual Meeting, Virtual Online, 02/22/2021 - 02/26/2021
Shin K, Fujimoto LM, Kent JE, Aleshin A, Tian Y, Bobkov AA, Im W, Marassi FM, Coordination of age-related macular degeneration pathogenesis by vitronectin, Biophysical Society 2022 Annual Meeting, San Francisco, CA, USA, 02/19/2022 - 02/23/2022
Shin K, Kent J, Thompson R, Marassi FM, Mechanistic insight into the role of vitronectin in age-related macular degeneration, 2022 ARVO Annual Meeting, Denver, CO, USA, 04/30/2022 - 05/04/2022
 
International
Shin K, Pandey A, Anini Y, Rainey JK, Differential apelin isoform production and involvement in obesity, 19th International Symposium on Regulatory Peptides, Copenhagen, Denmark, 08/22/2012 - 08/25/2012
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Elucidating the role of preferential membrane-association in regulation of proprotein processing, 21st International Symposium on Regulatory Peptides, Rouen, France, 07/11/2016 - 07/15/2016
Shin K, Sarker M, Huang SK, Anini Y, Rainey JK, Testing for membrane-modulated proprotein processing, 16th International Conference of Biochemistry and Molecular Biology, Vancouver, BC, Canada, 07/17/2016 - 07/21/2016
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Graduate Student Education
09/2022 Biophysical Techniques in Biochemistry Capacity (Lecturer)
 

EXTRAMURAL TEACHING:
Graduate Student Education
11/2021 Sanford Burnham Prebys Medical Discovery Institute, Molecules to Systems Course Capacity (Teaching Assistant)
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Stephanie Pelletier, Dalhousie University, 05/2013 - 05/2015 Research Mentor
Sophie Hamr, Dalhousie University, 09/2013 - 05/2014 Research/Teaching Mentor
Ellie Scott, Dalhousie University, 09/2013 - 12/2013 Research/Teaching Mentor
Shuya Kate Huang, Dalhousie University, 09/2014 - 05/2016 Research/Teaching Mentor
Jessica Basta, Dalhousie University, 05/2015 - 09/2017 Research Mentor
Michael Landsman, Dalhousie University, 09/2015 - 05/2017 Research Mentor
Calem Kenward, Dalhousie University, 09/2015 - 05/2016 Research/Teaching Mentor
 
Graduate Students
PhD Students Advised
James Kent, Sanford Burnham Prebys Medical Discovery Institute, 09/2018 - 09/2022, Research Mentor
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Tian Y, Shin K, Aleshin AE, Im W, Marassi FM. Calcium-induced environmental adaptability of the blood protein vitronectin. Biophys J. 2022 Oct 18;121(20):3896-3906. PMCID: PMC9674982
2. Kent JE, Fujimoto LM, Shin K, Singh C, Yao Y, Park SH, Opella SJ, Plano GV, Marassi FM. Correlating the Structure and Activity of Y. pestis Ail in a Bacterial Cell Envelope. Biophys J. 2021 Feb 02;120(3):453-462. PMCID: PMC7895992
3. Shin K, Kent JE, Singh C, Fujimoto LM, Yu J, Tian Y, Im W, Marassi FM. Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation. Proc Natl Acad Sci U S A. 2020 Aug 04;117(31):18504-18510. PMCID: PMC7414086
4. Shin K, Lechtenberg BC, Fujimoto LM, Yao Y, Bartra SS, Plano GV, Marassi FM. Structure of human Vitronectin C-terminal domain and interaction with <i>Yersinia pestis</i> outer membrane protein Ail. Sci Adv. 2019 Sep;5(9):eaax5068. PMCID: PMC6739113
5. Shin K, Landsman M, Pelletier S, Alamri BN, Anini Y, Rainey JK. Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases. Amino Acids. 2019 Mar;51(3):395-405. PMCID: PMC7101949
6. Kenward C, Shin K, Rainey JK. Mixed Fluorotryptophan Substitutions at the Same Residue Expand the Versatility of <sup>19</sup> F Protein NMR Spectroscopy. Chemistry. 2018 Mar 07;24(14):3391-3396.
7. Shin K, Sarker M, Huang SK, Rainey JK. Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup. Sci Rep. 2017 Nov 13;7(1):15433. PMCID: PMC5684411
8. Dutta D, Shin K, Rainey JK, Fliegel L. Transmembrane Segment XI of the Na<sup>+</sup>/H<sup>+</sup> Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore. Sci Rep. 2017 Oct 16;7(1):12793. PMCID: PMC5643542
9. Shin K, Chapman NA, Sarker M, Kenward C, Huang SK, Weatherbee-Martin N, Pandey A, Dupré DJ, Rainey JK. Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands. Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1901-1912. PMCID: PMC5770203
10. Huang SK, Shin K, Sarker M, Rainey JK. Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics. Biochim Biophys Acta Biomembr. 2017 May;1859(5):767-778.
11. Read J, Clancy EK, Sarker M, de Antueno R, Langelaan DN, Parmar HB, Shin K, Rainey JK, Duncan R. Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor. PLoS Pathog. 2015 Jun;11(6):e1004962. PMCID: PMC4464655
12. Shin K, Pandey A, Liu XQ, Anini Y, Rainey JK. Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity FEBS Open Bio. 2013;3:328-333.
13. Shin K, Pandey A, Liu XQ, Anini Y, Rainey JK. Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity. FEBS Open Bio. 2013;3:328-33. PMCID: PMC3821026
14. Shin K, Kent JE, Aleshin AE, Tian Y, Fujimoto LM, Singh C, Marassi FM. Vitronectin, the major regulator of age-related macular degeneration. Biophys J. 2023 Feb 10;122(3S1):467a.
 
Books, Chapters, and Reviews
1. Shin K, Kenward C, Rainey JK. Apelinergic System Structure and Function. Compr Physiol. 2017 Dec 12;8(1):407-450. PMCID: PMC5821487
2. Pandey A, Shin K, Patterson RE, Liu XQ, Rainey JK. Current strategies for protein production and purification enabling membrane protein structural biology. Biochem Cell Biol. 2016 Dec;94(6):507-527. PMCID: PMC5752365
3. Shin K*, Kent JE*, Marassi FM. Membranes, Minerals and Magnets: Application of NMR Spectroscopy to Biological Interfaces. In: Bhunia A, Atreya HS, Sinha N, editors. NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces. London: Royal Society of Chemistry; Aug 2022. p. 496-529.
4. Alamri BN, Shin K, Chappe V, Anini Y. The role of ghrelin in the regulation of glucose homeostasis. Horm Mol Biol Clin Investig. 2016 Apr 01;26(1):3-11.