Faculty Collaboration Database

1. Assem, M., Bonvalot, S., Beltramo, J.L., Garrido, C., Dimanche-Boitrel, M.T., Genne, P., Rebibou, J.M., Caillot, D., Chauffert, B. (1994). Deleterious effect of serum proteins on the amphotericin B-induced potentiation of cisplatin in human colon cancer cells. Br J Cancer, 70:631-635.

2. Garrido, C., Chauffert, B., Pinard, D., Tibaut, F., Genne, P., Assem, M., Dimanche-Boitrel, M.T. (1995). Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line. Int J Cancer, 61:873-879.

3. Benderitter, M., Maingon, P., Abadie, C., Assem, M., Maupoil, V., Briot, F., Horiot, J.C., Rochette, L. (1995). Effect of in vivo heart irradiation on the development of antioxidant defenses and cardiac functions in the rat. Radiat. Res, 144(1):64-72.

4. Garrido, C., Mehlen, P., Fromentin, A., Hammann, A., Assem, M., Arrigo, A.P., Chauffert, B. (1996). Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. The doxorubicin-protecting effect of Hsp27. Eur J Biochem, 237(3):653-659.

5. Assem, M., Teyssier, J.R., Benderitter, M., Terrand, J., Laubriet, A., Javouhey, A., David, M., Rochette, L. (1997). Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Am J Pathol, 151:549-555.

6. Piard, F., Yaziji, N., Jarry, O., Assem, M., Martin, L., Bernard, A., Jacquot, J.P., Justrabo, E. (1998). Solitary plasmacytoma of the lung with light chain extracellular deposits: a case report and review of the literature. Histopathology, 32:356-361.

7. Lewden, O., Garcher, C., Assem, M., Morales, C., Rochette, L., Bron, A.M. (1998). Changes of the inducible heat shock protein 70 mRNA level in rat retina after ischemia and reperfusion. Ophthalmic Res, 30(5):291-4.

8. Justrabo, E., Zanetta, G., Martin, L., Assem, M., Mousson, C., Maurice-Estepa, L., Rifle, G., Tanter, Y. (1999). Irreversible glomerular lesions induced by crystal precipitation in a renal transplant after foscarnet therapy for cytomegalovirus infection. Histopathology, 34:365-369.

9. Creuzot-Garcher, C., Guerzider, V., Assem, M., Bron, A.M., Delannoy, P., Bara, J. (1999). Alteration of sialyl Lewis epitope expression in pterygium. Invest. Ophthalmol. Vis. Sci, 40(8):1631-6.

10. Dobsak, P., Courderot-Masuyer, C., Zeller, M., Vergely, C., Laubriet, A., Assem, M., Eicher, J.C., Teyssier, J.R., Wolf, J.E., Rochette, L. (1999). Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J. Cardiovasc. Pharmacol, 34(5):651-9.

11. Martin, L., Assem, M., Piard, F. (1999). Are there several types of colorectal carcinomas? Correlations with genetic data. Eur J Cancer Prev, 8, Suppl 1:S13-20.

12. Ecarnot-Laubriet, A., De Luca, K., Vandroux, D., Moisant, M., Bernard, C., Assem, M., Rochette, L., Teyssier, J.R. (2000). Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload. J Mol Cell Cardiol, 32(12):2385-95.

13. Chapusot, C., Assem, M., Martin, L., Chalabreysse, L., Benhamiche, A.M., Lignier, M.A., Chauffert, B., Teyssier, J.R., Faivre, J., Piard, F. (2001). Expression of p21 WAF1/CIP1 protein in colorectal cancers: study of its relation to p53 mutation and Ki67 antigen expression. Path Biol, 49:115-123.

14. Kuehl, P., Zhang, J., Lin, Y., Lamba, J., Assem, M., Schuetz, J., Watkins, P., Daly, A., Wrighton, S., Hall, S.D., Maurel, P., Relling, M., Brimer, C., Yasuda, K., Venkataramanan, R., Storm, S., Thummel, K., Boguski, M.S., Schuetz, E. (2001). Sequence diversity in cyp3A promoters and characterization of the genetic basis of polymorphic cyp3A5 expression. Nature Genet, 27:383-391.

15. Laubriet, A., Fantini, E., Assem, M., Cordelet, C., Teyssier, J.R., Athias, P., Rochette, L. (2001). Changes in HSP70 and P53 expression are related to the pattern of electromechanical alterations in rat cardiomyocytes during simulated ischemia. Mol. Cell. Biochem, 220(1-2):77-86.

16. Schuetz, E.G., Storm, S., Yasuda, K., Lecureur, V., Assem, M., Brimer, C., Lamba, J., Kim, R.B., Ramachandran, V., Komoroski, B.J., Venktaramanan, R., Cai, H., Sinal, C.J., Gonzalez, F.J., Schuetz, J.D. (2001). Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450. J Biol Chem, 276:39411-39418.

17. Ecarnot-Laubriet, A., Assem, M., Poirson-Bichat, F., Moisant, M., Bernard, C., Lecour, S., Solary, E., Rochette, L., Teyssier, J.R. (2002). Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload. Biochim. Biophys. Acta, 1586(3):233-42.

18. Assem, M., Schuetz, E.G., Leggas, M., Yasuda, K., Reid, G., Zelcer, N., Adachi, M., Strom, S., Evans, R., Moore, D.D., Borst, P., Schuetz, J.D. (2004). Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem, 279(21):22250-7.

19. Schuetz, E.G. et al. (2004). PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5. Pharmacol Rev, 56(2):159.

20. Lamba, J.K., Lamba, V., Yasuda, K., Lin, Y.S., Assem, M., Thompson, E., Strom, S., Schuetz, E.G. (2004). Expression of CAR splice variants in human tissues and their functional consequences. J Pharmacol Exp Ther, 311(2):811-21.

21. Lamba, V., Yasuda, K., Lamba, J.K., Assem, M., Davila, J., Strom, S., Schuetz, E.G. (2004). PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol Appl Pharmacol, 199(3):251-65.

22. Masson, D., Lagrost, L., Athias, A., Gambert, P., Brimer-Cline, C., Lan L., Schuetz, J.D., Schuetz, E.G., Assem, M. (2005). Expression of the pregnane X receptor (PXR) in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein Profile. Arterioscler, Thromb Vasc Biol, 25:2164-2169.

23. Masson, D., Pais de Barros, J.P., Zak, Z., Gautier, T., Le Guern, N., Assem, M., Chisholm, J.W., Paterniti, J.R. Jr, Lagrost, L. (2006). Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. J. Lipid. Res, 47(2):356-65.

24. Zhou, C.C., Assem, M., Watkins, P.B., Blumberg, B., Schuetz, E.G., Thummel, K.E. (2006). Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J. Clin. Invest, 116(6):1703-12.

25. Finkelstein, D., Lamba, V., Assem, M., Rengelshausen, J., Yasuda, K., Strom, S., Schuetz, E.G. (2006). The ADME Transcriptome in Hispanic versus White donor livers: Evidence of a Globally Enhanced NR1I3 (CAR, Constitutive Androstane Receptor) Gene Signature in Hispanics. Xenobiotica, 36(10-11):989-1012.

26. Marzolini, C., Tirona, R.G., Gervasini, G., Poonkuzhali, B., Assem, M., Lee, W., Leake, B.F., Schuetz, J.D., Schuetz, E.G., Kim, R.B. (2007). A common polymorphism in the bile acid receptor FXR is associated with decreased hepatic target gene expression. Mol. Endocrinol, 21(8):1769-80.

27. Pottier, N., Cheok, M.H., Yang, W., Assem, M., Tracey, L., Obenauer, J.C., Panetta, J.C., Relling, M.V., Evans, M.W. (2007). Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression. Hum. Mol. Genet, 16(19): 2261-71.

28. Masson, D., Qatanani, M., Sberna, A.L., Xiao, R., Pais de Barros, J.P., Grober, J., Deckert, V., Athias, A., Gambert, P., Lagrost, .L, Moore, D.D., Assem, M. (2008). Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. J. Lipid Res, 49(8):1682-91.

29. Pottier, N., Yang, W., Assem, M., Panetta, J.C., Pei, D., Paugh, S.W., Cheng, C., DenBoer, M., Relling, M.V., Pieters, R., Evans, W.E., Cheok, M.H. (2008). The SWI/SNF-chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia. J. Natl. Cancer Inst, 100:1792-1803.

30. Lin, Y.S., Yasuda, K., Assem, M., Cline, C., Barber, J., Li, C.W., Kholodovych, W., Ai N., Chen, J.D., Welsh, W.J., Ekins, S., Schuetz, E. (2009). The major human PXR splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug. Metab. Dispos, 37(6):1295-304.

31. Sberna, A.L., Assem, M., Gautier, T., Grober, J., Guiu, B., Jeannin, A., Pais de Barros, J.P., Athias, A., Lagrost, L., Masson, D. (2011). Constitutive androstane receptor activation stimulates fecal bile acid excretion and reverse cholesterol transport in mice. J. Hepatol, 55(1):154-61.

32. Sberna, A.L., Assem, M., Xiao, R., Ayers, S.D., Gautier, T., Guiu, B., Deckert, V., Chevriaux, A., Grober, J., Le Guern, N., Pais de Barros, J.P., Moore, D.D., Lagrost, L., Masson, D. (2011). Constitutive androstane receptor activation decreases plasma Apolipoprotein B-containing lipoproteins and atherosclerosis in LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol, 31:2232-9.

33. Assem, M., Sibenaller, Z., Agarwal, S., Al-Keilani, M.S., Alqudah, M.A.Y., Ryken, T.C. (2012). Enhancing Diagnosis, Prognosis and Therapeutic Outcome Prediction of Gliomas Using Genomics. OMICS, 16(3):113-22.

34. Agarwal, S., Al-Keilani, M.S., Alqudah, M.A.Y., Sibenaller, Z., Ryken, T.C., Assem, M. (2013). Tumor derived mutations of Protein Tyrosine Phosphatase Receptor Type K affect its function and alter sensitivity to chemotherapeutics in glioma. PLoS One, 8(5):e62852.

35. Alqudah, M.A.Y., Al-Keilani, M.S., Agarwal, S., Sibenaller, Z., Ryken, T.C., Assem, M. (2013). NOTCH3 is a Prognostic Factor that promotes glioma cell proliferation, migration and invasion via activation of Cyclin D1 and EGFR. PLoS One, 8(10):e77299.

36. Al-Ghabeish M, Scheetz T, Assem M, Donovan MD. (2015). Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal absorption. Mol Pharm. 12(8):2742-54.

37. Dhamankar V, Assem M, Donovan MD. (2015). Gene Expression and Immunochemical Localization of Major Cytochrome P450 Drug-Metabolizing Enzymes in Bovine Nasal Olfactory and Respiratory Mucosa. Inhal. Toxicol. 1-11.

38. Lombardi, MY and Assem, M. (2017). Glioblastoma genomics: A very complicated story. Doi: http://dx.doi.org/10.15586/codon.glioblastoma.2017

1. Pharmacogenomics; RxPrep Course Book; Naplex & CPJE; 2014 edition

2. Lombardi, MY and Assem, M. (2017). Glioblastoma genomics: A very complicated story. Doi: http://dx.doi.org/10.15586/codon.glioblastoma

3. Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine; Jones & Bartlett Learning editions, 2014

1. Mahfoud Assem, Claude Mossiat, Anne Javouhey-Donzel, Etienne Tatou, Michel David, Jean R. Teyssier, Luc Rochette. "Cardiac antioxidant defenses study in patients with non-obstructive cardiomyopathy and in rats." Research Poster Presentation, Groupe de Recherche et de Reflexion Cardiovasculaire (GRRC) meeting, 1995, Marseille, France

2. Jerome Terrand, Mahfoud Assem, Jean R. Rademakers, Martin W. Walker, Luc Rochette. “Effect of ischemia and reperfusion on enzymatic antioxidant defenses of isolated rat heart”. Research Poster Presentation, GRRC meeting, 1996, Lyon, France

3. Jerome Terrand, Claire Abadie, Mahfoud Assem, Jean R. Rademakers, Luc Rochette. "Effects of L-nitro arginine (LNA) on cardiac functional parameters and antioxidant enzyme activities during ischemia-reperfusion insult in rats". Research Poster Presentation, GRRC meeting, 1997, Arcachon, France

4. Aline Laubriet, Elizabette Fantini, Mahfoud Assem, Pierre Athias, Alain Grynberg, Jean R. Teyssier, Luc Rochette. "Changes in HSP70 and MnSOD transcripts levels during hypoxia-reoxygenation in cultured neonatal rat cardiomyocytes". Research Poster Presentation, GRRC meeting, 1997, Arcachon, France

5. Aline Laubriet, Mahfoud Assem, Anne Javouhey-Donzel, Jean R. Teyssier, Luc Rochette. "Changes in HSP70 and MnSOD transcripts levels during the development of right ventricular hypertrophy induced by monocrotaline in rats". Research Poster Presentation, GRRC meeting, 1997, Arcachon, France

6. Luc Rochette, Mahfoud Assem, Catherine Garcher, Olivier Lewden, Jean R. Teyssier, Alain Bron. "Expression of catalase gene in rat retina after ischemia and reperfusion". Research Poster Presentation, Association for Research in Visioon and Ophthalmology (ARVO) meeting, 1997, Fort Lauderdale, Fl.

7. Mahfoud Assem, Catherine Garcher, Olivier Lewden, Claude Morales, Luc Rochette, Jean R. Teyssier, Alain Bron. "Expression of suoperoxide dismutase gene in rat retina after ischemia and reperfusion". Research Poster Presentation, ARVO meeting, 1997, Fort Lauderdale, Fl.

8. Aline Laubriet, Elizabette Fantini, Mahfoud Assem, Pierre Athias, Alain Grynberg, Jean R. Teyssier, Luc Rochette. "Changes in HSP70 transcripts levels during hypoxia-reoxygenation in cultured neonatal rat cardiomyocytes". Research Poster Presentation, International Society for Hera Research (ISHR) meeting, 1997, Versailles, France.

9. Aline Laubriet, Mahfoud Assem, Luc Rochette, Jean R. Teyssier. "Increase in the p53 and p21 (waf1/Cip1) transcripts levels is associated with the progression of right ventricular hypertrophy in rats treated with monocrotaline". Research Poster Presentation, GRRC meeting, 1998, Lille, France

10. Aline Laubriet, Elizabette Fantini, Mahfoud Assem, Pierre Athias, Jean R. Teyssier, Luc Rochette. "The p53 protein is activated upon reoxygenation but not by hypoxia in cultured neonatal rat cardiomyocytes". Research Poster Presentation, GRRC meeting, 1998, Lille, France

11. Aline Laubriet, Mahfoud Assem, Luc Rochette, Jean R. Teyssier, Catherine Garcher, Alain Bron. "mRNA changes in the apoptosis implicated genes in ischemic rat retina". Research Poster Presentation, International Congress of Eye Research, 1998, Paris, France

12. Aline Laubriet, Mahfoud Assem, Luc Rochette, Jean R. Teyssier, Catherine Garcher, Alain Bron. "P53 and P21 (waf1/Cip1) transcripts levels in ischemic and reperfused rat retina". Research Poster Presentation, International Congress of Eye Research, 1998, Paris, France

13. Aline Laubriet, Mahfoud Assem, Luc Rochette, Jean R. Teyssier, Catherine Garcher, Alain Bron. "Time related changes in P53 and P21 (waf1/Cip1) transcripts levels in ischemic rat retina". Research Poster Presentation, International Congress of Eye Research, 1998, Paris, France

14. Aline Laubriet, Mahfoud Assem, Luc Rochette, Jean R. Teyssier. "Downregulation of cyclin-dependent kinase inhibitor p27/Kip1 in pressure-overload hupertrophy". Research Poster Presentation, GRRC meeting, 1999, Lille, France

15. Mahfoud Assem, Erin G. Schuetz, David D. Moore, David Masson, Anne Athias, Philippe Gambert, Laurent Lagrost, Lubin Lan, and John D. Schuetz. "Mrp4 knockout reveals role in bile acid homeostasis and nuclear receptor signaling" Research Poster Presentation, AACR meeting, 2003, Orlando, Fl

16. Yvonne S. Lin, Lubin Lan, Mahfoud Assem, Jens Rengelshausen, Richard B. Kim and Erin G. Schuetz. "Development of an in vivo model for human MDR (P-glycoprotein) expression". Research Poster Presentation, ISSX, 2003, Dijon, France

17. Yvonne S. Lin, Lubin Lan, Mahfoud Assem, Jens Rengelshausen, Richard B. Kim and Erin G. Schuetz. "Development of an in vivo model for human MDR (P-glycoprotein) expression". Research Poster Presentation, PharmgKB, 2004, Los Angeles, CA

18. Mahfoud Assem, Erin G. Schuetz, Mark Leggas, Masashi Adachi and John D. Schuetz. "Hepatic Mrp4 and Sult2a1 regulatory interactions revealed by the CAR and Mrp4 knockouts". Research Poster Presentation, St. Jude Children's research hospital regional meeting, 2004, Memphis, TN

19. Mahfoud Assem, David Masson, Erin G. Schuetz, Anne Athias, Philippe Gambert, Laurent Lagrost, Lubin Lan, Kelly Mercer, Masashi Adachi, Jessica A. Morgan, David D. Moore, and John D. Schuetz. “Mrp4 knockout reveals role in bile acid homeostasis and nuclear receptor signaling”. Research Poster Presentation, St. Jude Children Research Hospital regional meeting, 2005, Memphis, TN

20. Mahfoud Assem, Erin G. Schuetz, Mark Leggas, Masashi Adachi and John D. Schuetz. "Hepatic Mrp4 and Sult2a1 regulatory interactions revealed by the CAR and Mrp4 knockouts". Research Poster Presentation, AACR meeting, April 2005, Anaheim, CA

21. David Masson, Laurent Lagrost, Andreece Richardson, Anne Athias, Philippe Gambert, Yvonne Lin, Lubin Lan, John D. Schuetz, Erin G. Schuetz, and Mahfoud Assem. "Expression of the pregnane X receptor (PXR) in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein Profile". Research Poster Presentation, International society of atherosclerosis meeting, 2005, Biarritz, France

22. Mahfoud Assem, Erin G. Schuetz, David D. Moore, David Masson, Anne Athias, Philippe Gambert, Laurent Lagrost, Lubin Lan, and John D. Schuetz. "Mrp4 knockout reveals role in bile acid homeostasis and nuclear receptor signaling". Research Poster Presentation, ABC meeting, 2005, NCI, Frederick, Md

23. Mahfoud Assem, David Masson, Erin G. Schuetz, Anne Athias, Philippe Gambert, Laurent Lagrost, Lubin Lan, Kelly Mercer, Masashi Adachi, Jessica A. Morgan, David D. Moore, and John D. Schuetz. “Mrp4 knockout reveals role in bile acid homeostasis and nuclear receptor signaling”. Research Poster Presentation, Nuclear receptors meeting, 2006, Banf, Alberta, Canada

24. Denise Morris, Mahfoud Assem, and Lawrence Fleckenstein. "Effect of Inflammation on Cyp3a11 and Mrp2 mRNA Expression in P-glycoprotein (Pgp) Deficient Mice". Research Poster Presentation, AAPS meeting, Nov 16-20, 2008, Atlanta, GA.

25. Mahfoud Assem, Zita Sibenaller, Joyce Marner, Thomas Bair, and Timothy C. Ryken. "Genomics Profiling as a Tool to Improve Diagnosis and Treatment of malignant Gliomas" Research Poster Presentation, AACR meeting, April 18-22, 2009, Denver, Co.

26. Anne-Laure Sberna, Mahfoud Assem, Laurent Lagrost, and David Masson. "Activation of the constitutive androstane receptor (CAR) decreases plasma triglycerides and LDL cholesterol levels and reduces atherosclerotic lesions in LDL receptor-deficient mice" Research Poster Presentation, ISA, June 14-18, 2009, Boston, MA

27. Mahfoud Assem, Zita Sibenaller, Joyce Marner, Supreet Agarwal, and Timothy C. Ryken. "Genomic and Transcriptomic Profiling as Tools to Improve Diagnosis and to Individualize Treatment of Malignant Gliomas" Research Poster Presentation, SNO meeting, October 22-25, 2009, New Orleans, LA.

28. Mahfoud Assem, Zita Sibenaller, Supreet Agarwal, Maha Al-Keilani, Mohammad Alqudah, Joyce Marner, and Timothy C. Ryken. "Chromosome 19 amplification and the consequent NOTCH and VEGF pathways over-activation are associated with malignant glioma poor outcome." Research Poster Presentation, AACR, April 17-21st, 2010, Washington DC.

29. Mahfoud Assem, Zita Sibenaller, and Timothy C. Ryken. "NOTCH and VEGF pathways amplifications are associated with malignant glioma outcome." Research Poster Presentation, CCOM research week, April 11-14, 2010, Carver College of Medicine, Iowa City, IA.

30. Supreet Agarwal, Maha S. Al-Keilani, Mohammad A.Y. Alqudah, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "Receptor protein tyrosine phosphatase type K (PTPRK) as a potential tumor suppressor and a predictive marker in gliomas". Research Poster Presentation, CCOM research week, April 12-14, 2011, Carver College of Medicine, Iowa City, IA.

31. Supreet Agarwal, Maha S. Al-Keilani, Mohammad A.Y. Alqudah, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "Receptor protein tyrosine phosphatase type K (PTPRK) as a potential tumor suppressor and a predictive marker in gliomas". Research Poster Presentation, AAPS meeting, October 23-27, 2011, Washington DC.

32. Mohammad A.Y. Alqudah, Supreet Agarwal, Maha S. Al-Keilani, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "NOTCH3 as a Potential Predictive Biomarker in Malignant Glioma". Research Poster Presentation, CCOM research week, April 1-4, 2012, Carver College of Medicine, Iowa City, IA.

33. Supreet Agarwal, Maha S. Al-Keilani, Mohammad A.Y. Alqudah, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "Receptor protein tyrosine phosphatase type K (PTPRK) as a potential tumor suppressor and a predictive marker in gliomas". Research Poster Presentation, AAPS meeting, October 23-27, 2011, Washington DC.

34. Supreet Agarwal, Maha S. Al-Keilani, Mohammad A.Y. Alqudah, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "Receptor protein tryosine phosphatase type K (PTPRK) is a prognostic marker essential for regulating malignant behavior of glioma cells". Research Poster Presentation, AACR meeting, March 30th- April 4th, 2012, Chicago IL.

35. Mohammad A.Y. Alqudah, Supreet Agarwal, Maha S. Al-Keilani, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. "NOTCH3: A Potential Predictive Biomarker in Malignant Glioma". Research Poster Presentation, ACCP meeting, October 21- 24, 2012, Hollywood, Fl.

36. Manar Al-Ghabeish, Todd Scheetz, Mahfoud Assem, and Maureen Donovan. "Expression of drug transporters in animal models used for nasal absorption characterization". Research Poster Presentation, AAPS meeting, Oct. 14-18, 2012, Chicago, Il.

37. Maha Al-Keilani, Supreet Agarwal, Mohammad Alqudah, Zita Sibenaller, Timothy C. Ryken, and Mahfoud Assem. "Tyrosyl DNA Phosphodiesterase I (TDP1): A Promising Predictive and prognostic Biomarker in Malignant Glioma". Research Poster Presentation, PGSRM, April 6-10, 2013, Omaha, Ne.

38. Maha Al-Keilani, Supreet Agarwal, Mohammad Alqudah, Zita Sibenaller, Timothy C. Ryken, and Mahfoud Assem. "Tyrosyl DNA Phosphodiesterase I is a Prognostic Factor and its Inhibition Synergizes Response to Topoisomerase Poisons in Malignant Glioma". Research Poster Presentation, AACR, April 6-10, 2013, Washington DC.

1. Genbank submissions: www.ncbi.nlm.nih.gov; 103 submissions

2. Patent: Genotyping assay to predict cytochrome P4503A5 (CYP3A5) expression. July 2003: US#20030143537; April 2006: US#7022475; May 2006: US#20060110767. I identified the genetic reason some persons do not express the CYP3A5 protein and made the groundbreaking discovery that the CYP3A5 genotype affects the clearance of CYP3A substrates, significantly affecting the potency and efficacy of drugs processed by this enzyme. Specifically, I identified and characterized the major splice variants and the associated SNP causing alteration of CYP3A5 activity. These alterations are the major determinant of CYP3A5 expression and potentially explain the inter-individual and inter-ethnic variabilities. I developed a genotyping testing for CYP3A5 variants that can be used as a tool to improve and adapt dosing and to predict efficacy and reduce toxicity/side effects for numerous drugs with narrow therapeutic windows.