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CURRICULUM VITAE

Mariko Suchi MD, PhD
Associate Professor
Department of Pathology
Division of Administration

OFFICE ADDRESS:
Children's Hospital
9000 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
04/1977 - 03/1983 M. D., Nagoya City University Medical School, Nagoya, Japan
04/1983 - 03/1987 Ph.D., Nagoya City University Medical School, Postgraduate School, Nagoya

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
04/1987 - 07/1988 Fellow, Pediatrics, Nagoya City University Hospital, Nagoya, Japan
08/1988 - 02/1991 Postdoctoral Fellow, Pediatrics, Mount Sinai School of Medicine, New York
01/1990 - 06/1990 Visiting Research Fellow, Molecular Biology, Sloan-Kettering Cancer Center, New York
02/1992 - 06/1993 Fellow, Pediatrics, Nagoya, City University Hospital, Nagoya, Japan
07/1996 - 06/2000 Resident, Anatomic and Clinical Pathology, University of Michigan Medical Center, Ann Arbor
07/2000 - 06/2002 Fellow, Pediatric Pathology, The Children's Hospital of Philadelphia, Philadelphia

MILITARY SERVICE:
None.

FACULTY APPOINTMENTS:
03/1991 - 02/1992 Assistant Professor, Pediatrics, Mount Sinai Medical Center, New York
07/1993 - 03/1994 Junior attending physician (Joshu), Virology, Nagoya City University Medical School, Nagoya, Japan
04/1994 - 06/1996 Junior Attending Physician (Joshu), Pediatrics, Nagoya City University Medical School, Nagoya, Japan
07/1996 - 03/1999 Visiting Assistant Professor, Pediatrics, Nagoya City University Medical School, Nagoya, Japan
07/2002 - 08/2005 Assistant Professor, Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
09/2005 - 06/2011 Assistant Professor, Pathology, Medical College of Wisconsin
07/2011 - Present Associate Professor, Pathology, Medical College of Wisconsin

ADMINISTRATIVE APPOINTMENTS:
04/1995 - 06/1996 President, Organization of Junior Faculty, Nagoya City University Medical School, Nagoya, Japan
04/1995 - 06/1996 Treasurer, Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
04/2006 - 04/2016 Organizer, Gastrointestinal and liver pathology lecture series, Department of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI
12/2006 - Present Organizer, Gastrointestinal and liver pathology rotation for pediatric gastroenterology fellows, Department of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI
09/2007 - 06/2012 Organizer, Pediatric Pathology Seminar Series, Department of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI
09/2016 - Present Organizer and presenter, Gastrointestinal working conference, Department of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
10/22/2007 - 03/14/2008 Member, Continual Service Readiness Patient Tracers

HOSPITAL STAFF PRIVILEGES:
07/1993 - 06/1996 Pediatrics, Nagoya City University Hospital, Nagoya, Japan
07/1993 - 06/1996 Pediatrics, Johoku Hospital, Nagoya, Japan
07/2002 - 08/2005 Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA
09/2005 - Present Pathology, Children's Hospital of Wisconsin, Milwaukee, WI
03/2012 - Present Pathology, Froedtert Hospital, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
Japan Pediatric Society, Pediatrics
06/26/1990
03/31/2020
American Board of Pathology, Anatomic and Clinical Pathology
09/11/2000
None
American Board of Pathology, Pediatric Pathology
11/08/2001
None
Japan Pathology Society, Pathology (No. 03352)
08/01/2018
None
 
Certificates
Issued By Issue DateExpiration
ECFMG (Education Commission for Foreign Medical Graduates)
1983
None
 

Licensure
Number Issue DateExpiration
Japan
05/30/1983
None
State of Michigan
08/02/1999
01/31/2021
Commonwealth of Pennsylvania
03/24/2000
12/31/2020
State of Wisconsin
02/16/2005
10/31/2019
State of Illinois
05/20/2005
07/31/2020
 

AWARDS AND HONORS:
03/1983 - Present Summa Cum Laudis, Nagoya City University Medical School
11/1987 - Present Japan IBM Research Award - Japanese Society of Inherited Metabolic Disease
09/1989 - Present Young Investigator Award for Clinical Research - Eastern Society for Pediatric Research

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
06/1983 - Present Japan Pediatric Society
08/1987 - Present The Molecular Biology Society of Japan
11/1987 - Present Japanese Society for Inherited Metabolic Disease
1987 - Present American Society of Human Genetics
03/2000 - Present The Japanese Society of Pathology
05/2000 - Present Japanese Society of Laboratory Medicine
2000 - Present American Society of Clinical Pathologists

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
09/2002 - Present Reviewer/Pediatric and Developmental Pathology

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
PROJECT: CHW 08/59, GC 641 Microscopic Colitis in Children IRBNet #85989-1
Source:
IRB-CHW
 
Title:
PROJECT: PRO00018213 Molecular Genetic Study in Histidinemia
Source:
IRB-MCW
 
Prior
Peer Review
Title:
PROJECT: No. 2003-9-3498 PI, "Histidinemia: Categorizatoin of base changes identified in the histidase gene of histidinemic patients into mutations or polymorphisms"
Source:
IRB-Children's Hospital of Philadelphia
 
Title:
PROJECT: No. 2003-8-3423 PI, "Molecular analysis of histologically focal form of congenital hyperinsulinism: Are all due to loss of heterozygosity of 11p15?"
Source:
IRB-Children's Hospital of Philadelphia
 
Title:
PROJECT: No. 2001-9-4033 PI, "Normal histology of gastrointestinal tract: A study utilizing endoscopic biopsy material"
Source:
IRB-Children's Hospital of Philadelphia
 
Title:
PROJECT: Herpes Esophagitis in Children IRBNet #880253-2
Source:
IRB-CHW
 
Title:
PROJECT: CHW 08/46, GC 627 Embryonal rhabdomyosarcoma and loss of heterozygosity at 11p15" IRBNet #93369-1
Source:
IRB-CHW
 
Title:
Molecular genetic studies on histidinemia in the Japanese population
Source:
Ministry of Education, Science, and Culture, Japan
Role:
Principal investigator
Direct Funds:
$7,000
 
Title:
Molecular genetic studies on histidinemia in the Japanese population
Source:
Ministry of Education, Science, and Culture, Japan
Role:
Principal investigator, transferred to Yoko Kawai upon leaving Japan
Direct Funds:
$14,543
 
Title:
Transgenic mouse model for Barrett's esophagus
Source:
NIH
Role:
Co-investigator
Direct Funds:
$100,000
 
Title:
Islet dysregulation in infants with congenital hyperinsulinism
Source:
NIH
Role:
Co-investigator
Direct Funds:
$368,833
 
Non-Peer Review
Title:
Molecular genetic studies on hereditary orotic aciduria
Source:
Nitto Sicence Foundation, Japan
Role:
Research fellow
Direct Funds:
$2,353
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Mariko Suchi, "Hyperinsulinism, genetics of focal form" - Surgical Grand Rounds, The Children's Hospital of Philadelphia. Philadelphia, PA, 06/2004
Mariko Suchi, "Congenital Hyperinsulinism: Pathology and Genetics", Pathology Seminar, Medical College of Wisconsin, Milwaukee, WI, 12/2004
Speaker, "Management of Infants with Congenital Hyperinsulinism: The CHOP Hyperinsulinism Center Experience" - Pediatric Grand Rounds, The Children's Hospital of Philadelphia. Philadelphia, PA, 12/2004
 
National
Mariko Suchi, "KATP focal hyperinsulinism disease and pathology, " Hyperinsulinism Family Conference, Philadelphia, PA, 07/20/2003 - 07/21/2003
Mariko Suchi, "Pathologists' role in management of congenital hyperinsulinism: The Philadelphia experience", Symposium, Congenital hyperinsulinism and related disorders of insulin secretion - Clinical biochemical and genetic advances, Philadelphia, PA, 06/15/2006 - 06/16/2006
 
International
Mariko Suchi, "Retroviral-mediated transfer of the human acid sphingomyelinase cDNA into Niemann-Pick disease fibroblasts, " at 28th Chubu district meeting of Japan Pediatric Society, Gifu, Japan, 08/1992
Mariko Suchi, "Fundamental research toward gene therapy in inborn errors of metabolism, " Symposium on "Gene Therapy: Now and Future, " at 30th meeting of Japan Clinical Metabolism Society, Osaka, Japan, 04/1993
Mariko Suchi, "Hereditary orotic aciduria, " Workshop on "DNA diagnosis, " at 24th meeting of Japan Medical Society, Nagoya, Japan, 04/1995
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Regional
Suchi M, Schuchman EH, Lev-ran O, Quintern LE, Sandhoff K, and Desnick RJ.: Niemann-Pick A and B disease: Isolation of a full-length cDNA encoding human acid sphingomyelinase and evidence for alternative splicing. Presented at the annual meeting of the Eastern Society for Pediatric Research. (Winner of the best abstract presented by a fellow), New York, NY, 09/1989
Suchi M, Maki N, Mizuguchi H, Sugiyama N, and Wada Y.: Carnitine palmityltransferase deficiency: The second case described in Japan. Presented at the Chubu district meeting of Japan Pediatric Society. September 1984, Nagoya, Japan.
 
National
Nakajima T, Suchi M, Hayakawa H, Kawase J, Ogino T, Kamiya K, Watanabe I, Togari H, Ogawa Y, and Wada Y.: Effects of indomethacin therapy on serum electrolytes in premature infants with PDA. Presented at the 20th Study Group on Immature babies and neonates. Morioka, Japan, 10/1983
Matsumoto N, Sugiyama N, Suchi M, Eguchi H, Nakajima T, Kawase J, Kamiya K, Watanabe I, Togari H, Ogawa Y, and Wada Y.: Carnitine metabolism in newborn infants. Presented at the 20th Study Group on Immature babies and neonates. Morioka, Japan, 10/1983
Sugiyama N, Morishita H, Suchi M, Maki N, Mizuguchi K, Kato T, Sugiyama K, Kato T, Wada Y, and Nonaka I.: Carnitine palmityltransferase deficiency: Its heterogeneity. Presented at the 27th Study Group on Pediatric Metabolic Diseases. Sapporo, Japan, 10/1984
Mizuguchi K, Suchi M, Yamada K, Sugiyama K, Kato T, and Wada Y.: Effects of cornstarch therapy on two cases of glycogen storage disease I. Presented at 27th Study Group on Pediatric Metabolic Diseases. Sapporo, Japan, 10/1984
Suchi M, Kokubo M, Kato T, Morishita H, and Wada Y.: Pyrimidine metabolism in the first Japanese case of hereditary orotic aciduria. Presented at the 28th Japanese Society of Inherited Metabolic Disease meeting. Kumamoto, Japan, 11/1985
Suchi M, Kokubo M, Sumi S, Morishita H, and Wada Y.: The effect of early uridine supplement to a patient with hereditary orotic aciduria. Presented at the 22nd Japan Neonatology Society meeting. Tokyo, Japan, 07/1986
Yazaki M, Okajima K, Suchi M, Morishita H, Kobayashi M, and Wada Y.: Effects of uridine supplementation on DNA and protein synthesis in orotic aciduria cell lines. Presented at the 29th Japanese Society of Inherited Metabolic Disease meeting. Nagoya, Japa, 10/1986
Suchi M, Harada N, Wada Y, and Takagi Y.: Purification of human orotidine 5'-monophosphate decarboxylase and cloning of its cDNA. Presented at the 30th Japanese Society of Inborn Errors of Metabolism meeting. Matsuyama, Japan, 10/1987
Suchi M, Harada N, Wada Y, and Takagi Y.: Molecular cloning of human orotidine 5'-phosphate decarboxylase cDNA. Presented at the 10th annual meeting of the Molecular Biology Society of Japan. Kyoto, Japan, 11/1987
Schuchman EH, Quintern LE, Suchi M, Snir O, Sandhoff K, and Desnick RJ.: Isolation of a full-length cDNA encoding human acid sphingomyelinase: Evidence for alternative splicing. Presented at the American Pediatric Society Meeting., Washington, DC, 05/1989
Quintern LE, Schuchman EH, Gartner S, Ferlinz K, Lev-ran O, Suchi M, Reinke H, Zunk Th.S, Meyer H, Desnick RJ, and Sandhoff K.: cDNA cloning of human acid sphingomyelinase and acid ceramidase. Presented at the annual meeting of Gesellshaft Deutscher Chemiker. Bonn, FRG, 09/1989
Takahashi T, Takada G, Suchi M, Desnick RJ, and Schuchman EH.: Identification and expression of acid sphingomyelinase gene mutations of types A and B Niemann-Pick disease. Presented at the 35th Japanese Society of Inherited Metabolic Disease m, 11/1992
Suchi M, Dinur T, Desnick RJ, Gatt S, and Schuchman EH.: In situ sphingomyelinase activity assay using N-[10-(1-pyrene)-decanoyl] sphingomyelin - Its applications. Presented at the 35th Japanese Society of Inherited Metabolic Disease mee, 11/1992
Suchi M, Desnick RJ, and Schuchman EH.: Retrovirus- mediated transfer of the human acid sphingomyelinase cDNA into Niemann-Pick disease fibroblasts. Presented at the 15th annual meeting of the Molecular Biology Society o, Japan, 12/1992
Suchi M, Harada N, Wada Y, and Takagi Y.: Molecular cloning of a cDNA encoding human histidase. Presented at the annual meeting of Japanese Society of Inherited Metabolic Disease. Sendai, Japan, 10/1993
Suchi M, Eksioglu YZ, Mizuno H, and Wada Y.: Molecular cloning and characterization of the human histidase gene. Presented at the 37th Japanese Society of Inherited Metabolic Disease meeting. Okayama, Japan, 11/1994
Takahashi T, Suchi M, Sato W, Hayasaka K, Sakuragawa N, Sukegawa K, and Takada G.: Molecular genetic analysis of type A Niemann-Pick disease. Presented at the 37th Japanese Society of Inherited Metabolic Disease meeting. Okayama, Japan, 11/1994
Sumi S, Suchi M, Morishita H, Tsuboi T, Ohba S, Kidouchi K, Toyama J, and Wada Y.: Pyrimidine analysis of a hereditary orotic aciduria patient - Uridine supplementation and pyrimidine metabolism. Presented at the 93rd Japan Pediatric Society meeting. Gifu, Japan, 03/1995
Imaeda M, Kidouchi K, Sumi S, Ohba S, Suchi M, Kobayashi M, Morishita H, and Wada Y.: A hereditary orotic aciduria family discovered by a urinary screening protocol for the pyrimidine metabolilm disorders. Presented at the 38th Japanese Society of Inherited Metabolic Dise, 10/1995
Toyama T, Kobayashi S, Iwase H, Yamashita T, Ito K, Yamashita K, Suchi M, Kato T, and Masaoka A.: Microsatellite instability and cancer-related gene abnormalities in sporadic human breast cancers. Presented at the 18th annual meeting of the Molecular Biology Society of Japan. Nago, 12/1995
Imaeda M, Sumi S, Suchi M, Kidouchi K, Ohba s, Imaeda H, Kobayashi M, and Wada Y.: A heterozygote family of hereditary orotic aciduria - case report. Presented at the 29th Japanese Association of Purine and Pyrimidine Metabolism meeting. Osaka, Japan, 02/1996
Sano H, Suchi M, Moriyama A, Tada T, Asai K, and Kato T.: Basic study on histidinemia - Regional distribution and organ-specific localization of rat histidase. Presented at the 19th annual meeting of the Molecular Biology Society of Japan. Sapp, 08/1996
Mizuno H, Suchi M, Kawai Y, and Wada Y.: Molecular genetic study of hereditary orotic aciduria - Cloning of the UMP synthase gene. Presented at the 39th Japanese Society of Inherited Metabolic Disease meeting. Tokyo, Japan, 11/1996
Kawai Y, Suchi M, Mizuno H, Tsuboi T, Okajima K, Sumi S, and Wada Y.: Molecular genetic study of hereditary orotic aciduria - Identification of three mutations in UMP synthase gene and their effect on enzyme activities. Presented at the 39th Japanese Socie, 11/1996
Kawai Y, Moriyama A, Morishita H, Miyachi T, Togari H, Sumi S, Asai K, and Suchi M.: Molecular genetic study on histidinemia: a 12-year-old girl with autistic trait. Presented at the 47th Japanese Society of Inherited Metabolic Disease meeting. Utsunomiya, Japan, 11/2004
Wintering N, Reddy S, Saffer J, Karp J, Freifelder R, Kachur A, Stanley C, Adzick NS, Suchi M, Hardy O, Litman R, Zhuang HM, and Alavi A.: 18F-labeled L-fluoro-DOPA PET scan localization of pancreatic lesions in infants with hyperinsulinism. Presented at the 52nd annual meeting of Society of Nuclear Medicine., Toronto, Ontario, 06/18/2005 - 06/22/2005
Hartemink, DA, Suchi M, Sulman C.: Case report: Lingual glial choristoma in a 9 month old. Presented at the annual meeting of Society for Ear Nose and Throat Advances in Children., Milwaukee, WI, 11/29/2007 - 12/02/2007
Larson-Nath C, Martinez A, Suchi, M, Cabrera J.: Langerhans cell histiocytosis (LCH) presenting with vomiting and duodenal narrowing. Presented at the annual meeting of North American Society for Pediatric Gastroenterology, Hepatology and Nutrition., Chicago, IL, 10/10/2013 - 10/13/2013
Lake JA, Ehrhardt MJ, Suchi M, Chun RH, Willoughby RE.: Non-toxigenic Corynebacteium diphtheria as an emergning pathologen: case report of necrotizing epiglottitis and tonsillitis in a child with undiagnosed acute lymphoblastic leukemia. Presented at the annual meeting of the American Society of Pediatric Heamtology/Oncology., Chicago, IL, 05/14/2014 - 05/17/2014
Berman MA, Encalada S, Ruiz JP, Suchi M, Sulman CG.: Metastatic adrenocortical carcinoma presenting as persistent couch. Presented at the annual meeting of Society for Ear, Nose and Throat advances in Children, St. Louis, Missouri, 12/04/2014 - 12/07/2014
Schelling L, Suchi M, Jarzembowski JA, Gheorghe G.: Case presentation SH2015 - 0477- common variable immunodeficiency. Presented at Society for Hematopathology and European Association for Haematopathology Workshop 2015, Long Beach, CA, 10/29/2015 - 10/31/2015
Lam JC, Suchi M, Groth TW.:, Pediatric xanthogranulomatous pyelonephritis: A case Report. Presented at the Wisconsin Urological Society Annual Meeting, Madison, WI, 04/16/2016
Fritz J, Lerner D, Suchi M.: 1 34-year review of herpes simplex virus esophagitis in children. Does herpes lead to eosinophilic esophagitis or vice versa? Presented at the annual meeting of North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition., 09/2016
Rosenwald K, Suchi M, Sood M, Kovacic K.: Lymphocytic autoimmune enteric leiomyositis: a rare acquired cause of chronic intestinal pseudo-obstruction. Presented at the annual meeting of North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition., 09/2016
Chao, K, Becktell K, Suchi M, Phelan R.: Monotherapy treatment with cytarabine for ALK-positive histiocytosis in an infant. Presented at the 2018 ASPHO (The American society of Pediatric Hematology/Oncology) conference, Pittsburgh, PA, 05/02/2018 - 05/05/2018
Chisholm SA, Suchi M, and Griepentrog G.: Orbital aneurysmal bone cyst in an infant: a case report and review of the literature. Presented at the American Society of Opthalmic Plastic and Reconstructive Surgery Spring Conference, Austin TX, 05/31/2018 - 06/03/2018
Belongia M, Bhatt N, Houser K, Jarzembowski J, Suchi M, Kelly T, Maheshwari M, Knipstein J.: Diffuse midline glioma with osseous metastases at diagnosis: A case report. Presented at International Society of Pediatric Neuro Oncology (ISPNO), Denver, CO, 06/29/2018 - 07/03/2018
Tsuboi T, Suchi M, Oda T, and Wada Y.: Molecular analysis of the UMP synthase cDNA in a patient and her family of hereditary orotic aciduria (Type I). Presented at the annual meeting of the Japan Society of Human Genetics. Ts, Japan, 10/1992. Jpn. J. Human Genet. 38: 42, 1993.
 
International
Yazaki M, Okajima K, Asai K, Suchi M, Morishita H, Kobayashi M, and Wada Y.: Increase of protein synthesis by uridine supplement in lectin stimulated peripheral blood lymphocytes and EB virus transformed B cell line of hereditary orotic aciduria type I. Presented, 05/1987
Okajima K, Yamamoto T, Suchi M, and Wada Y.: A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil. Presented at the meeting of International Symposium of Purine and Pyrimid, Japan, 07/1988
Suchi M, Harada N, Tsuboi T, Wada Y, and Takagi Y.: Molecular cloning of human UMP synthase. Presented at the meeting of International Symposium of Purine and Pyrimidine Metabolism in Man. Hakone, Japan, 07/1988
Suchi M, Schuchman EH, and Desnick RJ.: Niemann-Pick Disease: Molecular genetics of acid sphingomyelinase. Presented at Fifth International Congress of Inborn Errors of Metabolism. June 1990, Asilomar, CA, 06/1990
Suchi M, Harada N, Ogawa H, Kawai Y, Sano H, Mizuno H, Morishita H, Ishikawa M, Saito H, Takagi Y, and Wada Y.: Molecular genetic studies on histidinemia: Isolation and expression of a full-length human histidase cDNA, characterization of the genomic structure, and mutation search among histidinemic patients. Presented at the third meeting of the International Society for Neonatal Screening. Boston, MA, 10/1996
Hardy O, Wanner L, O'Rourke S, Suchi M, Adzich NS, Alavi A, Stanley CA.: Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. Presented at European SPE/Lawson Wilkins Pediatric Endocrine Society (LWPES) 7th joint meeting. Pe, 09/21/2005 - 09/24/2005
Hinske M, Suchi M, Szabo S, and Gheorghe G.: Alk positive histiocytosis. Presented at Workshop on Accessory cell and histiocytic neoplasms at European Association for Hematopathology meeting. Basel, Switzerland, 09/07/2016
Kapavarupu PK, Sood MR, Simpson P, Suchi M, and Sengupta JN.: Visceral hyperalgesia in a post-inflammatory visceral pain rat model: role of curcumin. Presented at the 2018 meeting of Federation of Neurogastroenetrology and Motility, Amsterdam, the Netherlands, 8/29 - 9/1, 2018
Suchi M, Pereira LV, Desnick RJ, Gilboa E, and Schuchman EH.: Metabolic correction of Niemann-Pick disease (NPD) fibroblasts by retroviral-mediated gene transfer. Presented at 8th International Congress of Human Genetics. Washington D.C., 10/1991. Am. J. Hum. Gen. 49 (Suppl): 438, 1991.
Rosenwald K, Suchi M, Sood M, and Kovacic K.: Lymphocytic autoimmune enteric leiomyositis: a rare acquired cause of chronic intestinal pseudo-obstruction. Presented at World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. Montreal, Quebec, Canada, 10/5 - 8, 2016
Fritz J, Lerner D, and Suchi M.: A 34-year review of herpes simplex virus esophagitis in children: Does herpes lead to eosinophilic esophagitis or vice versa? Presented at World Congress of Pediatric Gastroenterology, Hepatology and Nutrition. Montreal, Quebec, Canada, 10/5 - 8, 2016
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
09/2005 - 06/2006 Sophomore Pathology Course, Case Based Learning and Laboratory Sessions
09/2006 - 06/2007 Sophomore Pathology Course, Gross Laboratory Sessions
09/2007 - 07/2008 Sophomore Pathology Course, Gross Laboratory Sessions
Clinical Fellows (pediatric gastroenterology)
 
Resident and Fellow Education
09/2005 - Present daily surgical pathology
04/2006 - 04/2016 Gastrointestinal and liver pathology lecture series for the division of gastroenterology and nutrition, Department of Pediatrics
12/2006 - Present Pathology rotation for pediatric gastroenterology fellows. One week per year.
09/2016 - Present Gastrointestinal pathology working conference for the division of gastroenterology and nutrition, Department of Pediatrics
 

EXTRAMURAL TEACHING:
Medical Student Education
1987 - Present Lecturer, Pediatric Nursing, Nagoya City Nursing School
05/1994 - 06/1996 Lecturer, Pediatric Nursing, Nagoya City University College of Nursing
09/1996 - 12/1996 Tutorial assistant, Pathology, University of Michigan Dental School
09/1997 - 05/2000 Tutorial assistant, Pathology, University of Michigan Medical School
01/2004 - 03/2005 Pathology Laboratory, Mechanism of Disease and Therapeutic Intervention, University of Pennsylvania School of Medicine.
 
Resident and Fellow Education
Tatsuya Toyama, M.D. Microsatellite instability in sporadic human breast cancers
Yuji Okada, M.D. Noncardiogenic pulmonary edema as the chief manifestation of a pheochromocytoma: a case report of MEN2A with pedigree analysis of the RET proto-oncogene.
 
Graduate Student Education
Yoko Kawai, R.N. Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene
Haruo Mizuno, M.D. Thesis title: Regulation of lipocortin 1 expression and its biological function in the central nervous system
Hirofumi Sano, M.D. Thesis title: Tissue distribution of histidase in rat
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Morishita H, Kokubo M, Sumi S, Suchi M, and Wada Y.: The first case of herediatry orotic aciduria in Japan. J. Japan Pediatr. Soc. 90: 2775-2778, 1986.
2. Ishikawa T, Horie M, Furuyama M, Ohuchi M, Awaya A, Sobajima H, Suchi M, Yamaguchi A, Okajima K, and Wanibe M.: Bioavailability of a film-coated tablet of valproate in nonfasting volunteers. Jpn. J. Psychiatry Neurol. 41: 693-698, 1987.
3. Yazaki M, Okajima K, Suchi M, Morishita H, and Wada Y.: Increase of protein synthesis by uridine supplement in lectin-stimulated peripheral blood lymphocytes and EB virus transformed B cell line of hereditary orotic aciduria. Tohoku J. Exp. Med. 153: 189-195, 1987.
4. Suchi M, Maki N, Mizuguchi H, Kato T, Sugiyama N, Wada Y, and Nonaka I.: Carnitine palmityltransferase deficiency: Clinical availability of long-chain and medium-chain triglycerides loading test. J. Japan Pediatr. Soc. 91: 3416-3423, 1987.
5. Suchi M.: Molecular genetic studies on hereditary orotic aciduria I. Purification of human orotidine 5'-monophosphate decarboxylase and cloning of its cDNA. Nagoya Med. J. 32: 207-220, 1988.
6. Quintern LE, Schuchman EH, Levran O, Suchi M, Ferlinz K, Reinke H, Sandhoff K, and Desnick RJ. Isolation of cDNA clones encoding human acid sphingomyelinase: Occurrence of alternatively processed transcripts. EMBO J. 8: 2469-2473, 1989.
7. Schuchman EH, Levran O, Suchi M, and Desnick RJ.: An MspI polymorphism in the human acid sphingomyelinase gene (SMPD1). Nucleic Acid Res. 19: 3160, 1991.
8. Schuchman EH, Suchi M, Takahashi T, Sandhoff K, and Desnick RJ.: Human acid sphingomyelinase - Isolation, nucleic acid sequence, and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266: 8531-8539, 1991.
9. Takahashi T, Suchi M, Desnick RJ, Takada G, and Schuchman EH.: Identification and expression of five mutations in the human acid sphingomyelinase gene causing types A and B Niemann-Pick disease. J. Biol. Chem. 267: 12552-12558, 1992.
10. Suchi M, Dinur T, Desnick RJ, Gatt S, Pereira L, Gilboa E, and Schuchman EH.: Retroviral- mediated transfer of the human acid sphingomyelinase cDNA: Correction of the metabolic defect in cultured Niemann-Pick disease cells. Proc. Natl. Acad. Sci. USA 89: 3227-3231, 1992.
11. Dinur T, Schuchman EH, Fibach E, Dagan A, Suchi M, Desnick RJ, and Gatt S.: Toward gene therapy for Niemann-Pick disease (NPD): Separation of retrovirally corrected and noncorrected NPD fibroblast using a novel fluorescent sphingomyelin. Human Gene Ther. 3: 633-639, 1992.
12. Suchi M, Harada N, Wada Y, and Takagi Y.: Molecular cloning of a cDNA encoding human histidase. Biochim. Biophys. Acta 1216: 293-295, 1993.
13. Suchi M, Sano H, Mizuno H, and Wada Y.: Molecular cloning and structural characterization of the human histidase gene (HAL). Genomics 29: 98-104, 1995.
14. Takahashi T, Suchi M, Sato W, Ten SB, Sakuragawa N, Desnick RJ, Schuchman EH, and Takada G.: Identification and expression of a misssense mutation (Y446C) in the acid sphingomyelinase gene from a Japanese patient with type A Niemann-Pick disease.: Tohoku J. Exp. Med. 177: 117-123, 1995.
15. Toyama T, Iwase H, Yamashita H, Iwata H, Yamashita T, Ito D, Hara Y, Suchi M, Kato T, Nakamura T, and Kobayashi S.: Microsatellite instability in sporadic human breast cancers. Int. J. Cancer 68: 447-451, 1996.
16. Toyama T, Iwase H, Iwata H, Hara Y, Omoto Y, Suchi M, Kato T, Nakamura T, and Kobayashi S.: Microsatellite instability in in situ and invasive sporadic breast cancers or Japanese women. Cancer Let. 108: 205-209, 1996.
17. Sumi S, Suchi M, Kidouchi K, Morishita H, Ohba S, and Wada Y.: Pyrimidine metabolism in hereditary orotic aciduria. J. Inher. Metab. Dis. 20: 104-105, 1997.
18. Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, and Wada Y.: Molecular characterization of UMP synthase gene and point mutations in hereditary orotic aciduria patients. Am. J. Hum. Gen. 60: 525-539, 1997.
19. Sano H, Tada T, Moriyama A, Ogawa H, Asai K, Kawai Y, Hodgson M E, Kato T, Wada Y, and Suchi M.: Isolation of a rat histidase cDNA sequence and expression in Escherichia coli. Evidence of extrahepatic/epidermal distribution. Eur. J. Biochem. 250: 212-221, 1997.
20. Imaeda M, Sumi S, Imaeda H, Suchi M, Kidouchi K, Togari H, and Wada Y.: Hereditary orotic aciduria heterozygotes accompanied with neurological symptoms. Tohoku J. Exp. Med. 185: 67-70, 1998.
21. Okada Y, Suchi M, Takeyama H, Hodgson ME, Kato T, and Manabe T.: Noncardiogenic pulmonary edema as the chief manifestation of a pheochromocytoma: a case report of MEN 2A with pedigree analysis of the RET proto-oncogene. Tohoku J. Exp. Med. 188: 177-187, 1999.
22. Suchi M, MacMullen C, Thornton PS, Ganguly A, Stanley CA, and Ruchelli ED.: Histopathology of congenital hyperinsulinism: A retrospective study with genotype correlations. Ped. Devel. Path. 6: 322-333, 2003.
23. Stanley CA, Thornton PS, Ganguly A, MacMullen C, Underwood P, Bhatia P, Stainkrauss L, Wanner L, Kaye R, Ruchelli E, Suchi M, Adzick NS.: Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. J. Clin. Endocrinol. Metab. 89: 288-296, 2004.
24. Suchi M, Thornton PS, Adzick NS, MacMullen C, Ganguly A, Stanley CA, and Ruchelli ED.: Congenital hyperinsulinism: Intraoperative biopsy interpretation can direct the extent of pancreatectomy. Am. J. Surg. Pathol. 28: 1326-1335, 2004.
25. Kawai Y, Moriyama A, Asai K, Coleman-Campbell CM, Sumi S, Morishita H, and Suchi M.: Molecular characterization of histidinemia: Identification of four missense mutations in the histidase gene. Human Genetics 116: 340-346, 2005.
26. Greco AJ, Baluarte JH, Meyers K, Sellers M, Suchi M, and Kaplan BS.: A case of chromophobe renal cell carcinoma in a pediatric living-related kidney transplant. Am J. Kidney Diseases 45: e105-108, 2005.
27. Suchi M, MacMullen C, Thornton PS, Adzick NS, Ganguly A, Ruchelli ED, and Stanley CA.: Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism. Modern Pathol 19: 122-129, 2006.
28. Hardy OT, Hernandez-Pampaloni M, Saffer JR, Suchi M, Ruchelli E, Zhuang H, Ganguly A, Freifelder R, Adzick NS, Alavi A, and Stanley CA.: Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. J Pediatr 150: 140-145, 2007.
29. Sayed S. Langdon DR, Odili S, Chen P, Buettger C, Schiffman AB, Suchi M, Taub R, Grimsby J, Matschinski FM, Stanley CA.: Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism due to glucokinase activating mutations. Diabetes 58: 1419 - 1427, 2009.
30. Reddy S, Geoffrey R, Jia S, Suchi M, Broekel U, Hessner M, Verbsky J.: Homozygous deletion at the 2q13 region encompassing the Il-1 receptor antagonist gene causes a NOMID-like syndrome with bone lesions. N Engl J Med 360, 2438 - 2444, 2009.
31. Dishop MK, McKay EM, Kreiger PA, Priest JR, Williams GM, Langston C, Jarzembowski J, Suchi M, Dehner LP, Hill DA.: Fetal lung interstitial tumor (FLIT): A proposed newly recognized lung tumor of infancy to be differentiated from cystic pleuropulmonary blastoma and other developmental pulmonary lesions. Am J Surg Pathol 34,1762 - 1772, 2010.
32. Sultan, MI, Suchi M, Werlin SL.: Cecal granular cell tumor. J Pediatric Gastroenterology Nutrition 52, 375, 2011.
33. Harrington A, Bell E, Suchi M, Behmaram B, Uyar D.: Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. Pediatr Dev Pathol, 14, 235-239, 2011.
34. Suburamanian S, Chandra T, Whitehouse J, Suchi M, Arca M, Maheshwari M.: Bronchogenic cyst in the intradiaphragmatic location. Wmj, 112, 262-264, 2013.
35. Daramola OO, Suchi M, Chun R.: Lingual hamartoma associated with a cleft palate in a newborn. Ear, Nose & Throat J 93, E9-E11, 2014.
36. Lake JA, Ehrhardt MJ, Suchi M, Chun RH, Willoughby RE.: A case of necrotizing epiglottitis due to nontoxigenic Corynebacterium diphtheria. Pediatrics 136, e242-e245, 2015.
37. Zei M, Meyers AB, Boyd KP, Larson-Nath C, Suchi M.: Langerhans cell histiocytosis of the digestive tract identified on an upper gastrointestinal examination. Pediatr Radiol 46, 1341 - 1344, 2016
38. Erker C, Huppler AR, Walsh TJ, McCormick ME, Suchi M, Batt NS, Kehl SC, Southwood J, Harker-Murray P.: Successful treatment of invasive Conidiobolus infection during therapy for acute lymphoblastic leukemia. J Pediatr Hematol Oncol Oct 17 PMID: 28991126 PMCID:PMC590405, 2017.
39. 38: Fritz J, Lerner D, Suchi M.: Herpes simplex virus esophagitis in immunocompetent children: A harbinger of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 66: 609-613, April 2018.
40. Jeschke JC, Mayne CG, Ziegelbauer J, DeCiantis CL, Singh S, Kumar SN, Suchi M, Iwakura Y, Drobyski WR, Williams CB: A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFN𝛄 to generate self-tolerance and prevent colitis. Mucosal Immunol 11: 1127 - 1137, 2018.
41. Khayat A, Suchi M, Vitola B.: A rare case of a 2 year old boy with Alagille syndrome and type 3 hereditary hemochromatosis with TFR2 mutation. J. Pediatr Gastroenterol Nutr July 06 PMID:29985876, 2018.
42. Huang H, Gheorghe G, North PE, Suchi M.: Expanding the phenotype of ALK-positive histiocytosis: A report of 2 cases. Pediatr Dev Patholol 21(5): 449 - 455, 2018.
43. Arocho-Quinones EV, Self S, Suchi M, Zwagerman NT, Lew SM.: Spheno-orbital aneurysmal bone cyst in a 10-month-old infant. World Neurosurgery 117: 371 - 376, 2018.
44. Scheuermann A, Belongia M, Laulor MW, Suchi M, Kaufman B, Vasudevaraja V, Serrano J, Snuderl, Knipstein J.: Ganglioglioma in a survivor of infantile glioblastoma. J Pediatr Hematol Oncol 00: 000-000, 2019.
 
Books, Chapters, and Reviews
1. Suchi M.: Histidinemia. in Tarui S, and Tada K (eds), Manual of Genetic Diseases. Molecular Medicine 32: 54-55, 1995. Nakayama-Shoten, Tokyo, Japan.
2. Suchi M.: Hereditary orotic aciduria. in Tarui S, and Tada K (eds), Manual of Genetic Diseases. Molecular Medicine 32: 232-233, 1995. Nakayama-Shoten, Tokyo Japan.
3. Mizuno H, Suchi M, and Wada Y.: Hereditary orotic aciduria. Ryoikibetsu Shokogun Shirizu 18 part 1: 484-486, 1998.
4. Suchi M.: The Pancreas. in Stocker JT, Husain AN, and Dehner LP (eds), Pediatric Pathology, 3rd ed. 743-778, 2011. Wolters Kluwer/Lippincott Williams &Wilkins, Philadelphia.
5. Suchi M.: The Pancreas. in Husain AN, Stocker JT, and Dehner LP (eds), Pediatric Pathology, 4th ed. 763-799, 2016. Wolters Kluwer/Lippincott Williams &Wilkins, Philadelphia.
 
Non-Refereed Journal Publications/Original Papers
1. Okajima K, Yamamoto T, Suchi M, and Wada Y.: A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil. Adv. Exp. Med. Biol. 253A: 119-122, 1989.
2. Suchi M, Harada N, Tsuboi T, Asai K, Okajima K, Wada Y, and Takagi Y.: Molecular cloning of human UMP synthase. Adv. Exp. Med. Biol. 253A: 511-518, 1989.
3. Nakajima I, Mitsuma T, Ueda R, Emi N, Suchi M, Doyu M, and Yoshida J.: Conference "Gene diagnosis and gene therapy". Gendai-Igaku (The Current Medicine) 43: 335-357, 1995.
 
Abstracts
1. Schuchman EH, Suchi M, Lev-ran O, Quintern LE, and Desnick RJ.: Isolation of a full-length cDNA encoding human acid sphingomyelinase: Evidence for alternative splicing. Presented at the annual meeting of the American Society of Human Genetics. Baltimore, MD, 11/1989. Am.. J. Hum. Gen. 45: A217, 1989.
2. Suchi M, Pereira LV, Desnick RJ, Gilboa E, and Schuchman EH.: Metabolic correction of Niemann-Pick disease (NPD) fibroblasts by retroviral-mediated gene transfer. Presented at the annual meeting of the American Society of Human Genetics, Washington D.C., 10/1991. Am. J. Hum. Gen. 49 (Suppl): 438, 1991.
3. Tsuboi T, Suchi M, Oda T, and Wada Y.: Molecular analysis of the UMP synthase cDNA in a patient and her family of hereditary orotic aciduria (Type I). Presented at the annual meeting of the Japan Society of Human Genetics. Tsukuba, Japan, 10/1992. Jpn. J. Human Genet. 38: 42, 1993.
4. Suchi M, Ogawa H, Wada Y, and Takagi Y.: Isolation and expression of a cDNA encoding human histidase. Presented at the annual meeting of the American Society of Human Genetics. Montreal, Quebec, Canada, 10/1994. Am. J. Hum. Gen. 55: A139, 1994.
5. Suchi M, Sano H, Mizuno H, and Wada Y.: Molecular cloning and characterization of the human histidase gene. Presented at the annual meeting of the American Society of Human Genetics. Minneapolis, MN, 10/1995. Am. J. Hum. Gen. 57: A151, 1995.
6. Sano H, Suchi M, Moriyama A, Tada T, Kato T, and Wada Y.: Biochemical investigation of hitidinemia: functional organization and distribution of histidase. Presented at the annual meeting of the American Society of Human Genetics. San Francisco, CA, 10/1996. Am. J. Hum. Gen. 59: A207, 1996.
7. Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson M E, Ogawa H, and Wada Y.: Molecular investigation of hereditary orotic aciduria: cloning of the human UMP synthase gene and characterization of mutations in two Japanese families. Presented at the annual meeting of the American Society of Human Genetics. Baltimore, MD, 10/1997. Am. J. Hum. Gen. 61: A262, 1997.
8. Judd WJ, Davenport RD, and Suchi M.: An enzyme only IgG C3-binding alloantiC causing acute hemolytic transfusion reaction. Presented at the annual meeting of the American Association of Blood Banks. Washington D.C., 11/2000. Transfusion 40(S): 119, 2000.
9. Suchi M, Thornton PS, Stanley CA, and Ruchelli ED.: Hyperinsulinism - Are there only two histologic forms? Presented at the annual meeting of the Society for Pediatric Pathology. Atlanta, GA, 03/2001. Modern Pathol. 14: 5P, 2001.
10. Suchi M, Thornton PS, Adzick NS, MacMullen C, Ganguly A, Stanley CA and Ruchelli ED.: Congenital hyperinsulinism: Intraoperative biopsy interpretation can direct the extent of pancreatectomy. Presented at the annual meeting of the United States and Canadian Academy of Pathology. Washington D.C., 03/2003. Modern Pathol. 16: 110A, 2003.
11. Suchi M, MacMullen C, Adzick NS, Ganguly A, Stanley CA, and Ruchelli ED.: Congenital hyperinsulinism: Genetic etiology of focal form. Presented at the annual meeting of the United States and Canadian Academy of Pathology. Vancouver, BC, Canada, 03/2004. Modern Pathol. 17: 107A, 2004.
12. Suchi M.: How many plasma cells are too many for gastric antrum in children? Presented at the annual meeting of the United States and Canadian Academy of Pathology. Atlanta, GA, 02/2006. Lab. Invest. 86, Supplement 1: 120A-121A, 2006
13. Ernst LM, Suchi M, Stanley CA, Adzick NS, MacMullen C, and Ruchelli, ED.: Localized islet cell nuclear enlargement in congenital hyperinsulinism: A distinct clinicopathologic entity. Presented at the annual meeting of the Society for Pediatric Pathology. San Diego, CA, 03/2007. Modern Pathol 20: 287, 2007.
14. Vasudev M, Reddy S, Kumar A, Suchi M, Schauer D, Noel RJ, Nocton JJ, Verbsky J, Grossman W.: Alternatively Spliced CIAS1 mRNA in a Variant Case of Muckle Wells Syndrome. Presented at the 2008 annual meeting of the American Academy of Allergy Asthma & Immunology. Philadelphila, PA. J Allergy Clin Immunol 121 (2): S81, 2008.
 

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