CURRICULUM VITAE
Matthew B. Veldman PhD
Matthew B. Veldman PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
09/1995 - 06/1999 BS, University of Minnesota, Twin Cities, MN |
09/1999 - 06/2007 PhD, University of Michigan, Ann Arbor, MI |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
07/01/2007 - 12/31/2014 Postdoctoral Fellow, Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, CA |
09/01/2014 - 12/31/2014 Adjunct Assistant Professor, Life Sciences, UCLA, Los Angeles, CA |
01/01/2015 - 08/31/2018 Staff Research Associate, Semel Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA |
FACULTY APPOINTMENTS: |
09/2018 - Present Assistant Professor, Department of Cell Biology, Neurobiology, and Anatomy, The Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
09/1996 - Present Dora Heinzen Memorial Scholarship |
09/1998 - Present Mortarboard National Honor Society |
09/1998 - Present Franklin Enfield Memorial Scholarship, University of Minnesota |
06/1999 - Present Magna cum laude, University of Minnesota |
06/1999 - Present Rackham Graduate Fellowship, University of Michigan |
06/2002 - Present Center for Organogenesis Predoctoral Fellowship, University of Michigan |
06/2004 - Present Vision Training Grant Predoctoral Fellowship, University of Michigan |
06/2007 - Present Developmental Hematology Postdoctoral Fellowship, UCLA |
06/2009 - Present Vascular Biology Training Program Postdoctoral Fellowship, UCLA |
09/23/2020 Emerging Vision Scientist, Alliance for Eye and Vision Research |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
08/01/2019 - Present International Society for Eye Research (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
05/01/2020 - Present Frontiers in Molecular Neuroscience |
Journal Review |
09/01/2018 - Present European Journal of Pharmacology |
09/01/2019 - Present PLoS ONE |
10/01/2019 - Present Molecular Vision |
08/01/2020 - Present International Journal of Developmental Biology |
11/01/2020 - Present Frontiers in Molecular Neuroscience |
11/01/2020 - Present Experimental Eye Research |
01/01/2021 - Present Frontiers in Cell and Developmental Biology |
03/01/2021 - Present Journal of Cellular Physiology |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
Matthew B Veldman, Shubhangi Prabhudesai, Workshop: Modeling Vascular Disease In Zebrafish, Vasculata 2019, Medical College of Wisconsin, 07/15/2019 - 07/18/2019 |
Regional |
Matthew B Veldman, Cell intrinsic and extrinsic mechanisms of successful optic nerve regeneration, McPherson Eye Research Institute at a glance, University of Wisconsin - Madison, 10/22/2019 |
Matthew B Veldman, Intercellular communications mediating successful optic nerve regeneration, Madfish group meeting, University of Wisconsin - Madison, 04/30/2020 |
Matthew B Veldman, "I know it when I see it...or do I?" New tools to classify cells as part of the BRAIN Initiative cell census network., UWM-Neuroscience seminar series, University of Wisconsin - Milwaukee, 11/06/2020 |
Matthew B Veldman, Ganglion cell intrinsic and extrinsic mechanisms of successful optic nerve regeneration, McPherson Eye Research Institute Kambara Symposium, University of Wisconsin - Madison, 04/16/2021 |
Local |
Matthew B Veldman, A genetic strategy for sparse cell labeling and manipulation in vivo and its application to study neuroanatomy, degeneration, and regeneration., Department of Biochemistry Seminar Series, Medical College of Wisconsin, 09/19/2018 |
Matthew B Veldman, A systematic pipeline for studying CNS development and regeneration., IDP seminar series, Medical College of Wisconsin, 10/03/2018 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Matthew B Veldman, Intercellular communication mediating successful optic nerve regeneration, ISER/BrightFocus Glaucoma Symposium, Emory University, Atlanta, GA, USA, 10/23/2019 - 10/26/2019 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
07/16/2020 - Present Member, MSTP Admissions, Medical College of Wisconsin |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2019 - 2021 Medical Neuroscience, Learning and Memory Lecture |
2019 - 2021 Medical Neuroscience active learning session on the basal nuclei, mediator |
Graduate Student Education |
04/24/2020 - 04/26/2020 Advanced Cell Biology lecture and journal club, topic: Localized Translation |
11/17/2020 - 11/19/2020 Biology of Vision lecture and journal club, topic: optic nerve biology, injury, and regeneration |
EXTRAMURAL TEACHING: |
Graduate Student Education |
09/2014 - 12/2014 UCLA, Life Sciences 2: Cells, Tissues, and Organ Systems |
COMMUNITY SERVICE ACTIVITIES: |
09/28/2019 - Present My family and I participated in the Froedtert and Medical College of Wisconsin Cancer Crush run/walk fundraiser for cancer research. |
09/23/2020 - Present As part of the Alliance of Eye and Vision Research Emerging Vision Scientist Program, I advocated for increased federal research funding for vision research by participating in virtual conference calls with the offices of Senator Ron Johnson, Senator Tammy Baldwin, and Representative Jim Sensenbrenner. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S. A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay. PLoS One. 2013;8(4):e53317. PMCID: PMC3637257 |
2. Yan G, Yan R, Chen C, Chen C, Zhao Y, Qin W, Veldman MB, Li S, Lin S. Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells. Protein Cell. 2018 Apr 23 [Epub ahead of print]. |
3. Veldman MB, Rios-Galdamez Y, Lu XH, Gu X, Qin W, Li S, Yang XW, Lin S. The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model. Mol Neurodegener. 2015 Dec 9;10:67. |
4. Lindgren AG, Veldman MB, Lin S. ETV2 expression increases the efficiency of primitive endothelial cell derivation from human embryonic stem cells. Cell Regen (Lond). 2015 Jan 7;4(1):1. |
5. Veldman MB*, Zhao C*, Gomez GA, Lindgren AG, Huang H, Yang H, Yao S, Martin BL, Kimelman D, Lin S. Transdifferentiation of Fast Skeletal Muscle into Functional Endothelium in Vivo by Transcription Factor Etv2. PLoS Biology. 2013 Jun;11(6):e1001590. doi: 10.1371/journal.pbio.1001590. Epub 2013 Jun 18. *co-first author |
6. Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S. A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay. |
7. PLoS One. 2013 Apr 26;8(4):e53317. doi: 10.1371/journal.pone.0053317. |
8. Gomez G, Lee J-H, Veldman MB, Lu J, Xiao X, Lin S. Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS ONE (2012) 7(3): e31658. doi:10.1371/journal.pone.0031658. |
9. Veldman MB, Lin S. Etsrp/Etv2 Is Directly Regulated by Foxc1a/b in the Zebrafish Angioblast. Circ Res. 2012 Jan 20;110(2):220-9. |
10. Veldman MB, Bemben MA, Goldman D. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Mol Cell Neurosci. 2010 Apr;43(4):370-83. |
11. Gomez GA*, Veldman MB*, Zhao Y, Burgess S, Lin S. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS ONE. 2009;4(3):e4994. *co-first author |
12. Suhr ST, Ramachandran R, Fuller CL, Veldman MB, Byrd CA, Goldman D. Highly-restricted, cell-specific expression of the simian CMV-IE promoter in transgenic zebrafish with age and after heat shock. Gene Expr Patterns. 2009 Jan;9(1):54-64. Epub 2008 Aug 6. |
13. Veldman MB, Bemben MA, Thompson RC and, Goldman D. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. Dec 15; 312 (2):596-612, 2007. |
14. Tang H, Veldman MB, Goldman D. Characterization of a muscle-specific enhancer in human MuSK promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation. J Biol Chem. 2006 Feb 17; 281(7):3943-53. |
15. Campbell KM, Veldman MB, McGrath MJ, Burton FH. TS+OCD-like neuropotentiated mice are supersensitive to seizure induction. Neuroreport 2000 Jul 14;11(10):2335-8. |
16. McGrath MJ, Campbell KM, Veldman MB, Burton FH. Anxiety in a transgenic mouse model of cortical-limbic neuro-potentiated compulsive behavior. Behav Pharmacol 1999 Sep;10(5):435-43. |
17. Veldman MB, Park CS, Eyermann CM, Zhang JY, Zuniga-Sanchez E, Hirano AA, Daigle TL, Foster NN, Zhu M, Langfelder P, Lopez IA, Brecha NC, Zipursky SL, Zeng H, Dong HW, Yang XW. Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice. Neuron. 2020 Oct 14;108(1):111-127.e6. PMCID: PMC7572760 |
18. Li R, Zhu M, Li J, Bienkowski MS, Foster NN, Xu H, Ard T, Bowman I, Zhou C, Veldman MB, Yang XW, Hintiryan H, Zhang J, Dong HW. Precise segmentation of densely interweaving neuron clusters using G-Cut. Nat Commun. 2019 Apr 04;10(1):1549. PMCID: PMC6449501 |
19. BRAIN Initiative Cell Census Network (BICCN). A multimodal cell census and atlas of the mammalian primary motor cortex. Nature. 2021 Oct;598(7879):86-102. PMCID: PMC8494634 |
20. Peng H, Xie P, Liu L, Kuang X, Wang Y, Qu L, Gong H, Jiang S, Li A, Ruan Z, Ding L, Yao Z, Chen C, Chen M, Daigle TL, Dalley R, Ding Z, Duan Y, Feiner A, He P, Hill C, Hirokawa KE, Hong G, Huang L, Kebede S, Kuo HC, Larsen R, Lesnar P, Li L, Li Q, Li X, Li Y, Li Y, Liu A, Lu D, Mok S, Ng L, Nguyen TN, Ouyang Q, Pan J, Shen E, Song Y, Sunkin SM, Tasic B, Veldman MB, Wakeman W, Wan W, Wang P, Wang Q, Wang T, Wang Y, Xiong F, Xiong W, Xu W, Ye M, Yin L, Yu Y, Yuan J, Yuan J, Yun Z, Zeng S, Zhang S, Zhao S, Zhao Z, Zhou Z, Huang ZJ, Esposito L, Hawrylycz MJ, Sorensen SA, Yang XW, Zheng Y, Gu Z, Xie W, Koch C, Luo Q, Harris JA, Wang Y, Zeng H. Morphological diversity of single neurons in molecularly defined cell types. Nature. 2021 Oct;598(7879):174-181. PMCID: PMC8494643 |
21. Arcuri J, Veldman MB, Bhattacharya SK. Lipidomics dataset of <i>Danio rerio</i> optic nerve regeneration model. Data Brief. 2021 Aug;37:107260. PMCID: PMC8327136 |
22. Senut MC, Fausett B, Veldman M, Goldman D. Gene Regulation During Axon and Tissue Regeneration in the Retina of Zebrafish Model Organisms in Spinal Cord Regeneration. 5 February 2007:373-394. |
23. Speer W, Veldman MB. LCM-Seq for Retinal Cell Layer-Specific Responses During Optic Nerve Regeneration. Methods Mol Biol. 2023;2636:311-321. |
24. Meehan SD, Hu M, Veldman MB, Bhattacharya SK. Metabolomics dataset of zebrafish optic nerve regeneration after injury Data in Brief. June 2023;48. |
25. Eisa-Beygi S, Hu MM, Kumar SN, Jeffery BE, Collery RF, Vo NJ, Lamichanne BS, Yost HJ, Veldman MB, Link BA. Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e231-e237. PMCID: PMC10330147 |
26. Akins KA, Flinn MA, Swift SK, Chanjeevaram SV, Purdy AL, Buddell T, Kolell ME, Andresen KG, Paddock S, Buday SL, Veldman MB, O'Meara CC, Patterson M. <i>Runx1</i> is sufficient but not required for cardiomyocyte cell-cycle activation. Am J Physiol Heart Circ Physiol. 2024 Aug 01;327(2):H377-H389. PMCID: PMC11442100 |
27. Veldman MB, Bhattacharya SK. Regeneration and Vision Restoration. J Ocul Pharmacol Ther. 2023 Oct;39(8):473. |
28. Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegener. 2023 Sep 21;18(1):64. PMCID: PMC10514988 |
29. Hu M, Veldman MB. Intraocular Axon Regeneration in a Model of Penetrating Eye Injury. J Ocul Pharmacol Ther. 2023 Oct;39(8):563-571. PMCID: PMC10616938 |
30. Meehan SD, Hu M, Veldman MB, Bhattacharya SK. Metabolomics dataset of zebrafish optic nerve regeneration after injury. Data Brief. 2023 Jun;48:109102. PMCID: PMC10293924 |
Books, Chapters, and Reviews |
1. Veldman MB, Yang XW. Molecular insights into cortico-striatal miscommunications in Huntington's disease. Curr Opin Neurobiol. 2018 Feb;48: 79-89. Review. |
2. Veldman MB, Yang XW. Huntington's Disease: Nuclear Gatekeepers Under Attack. Neuron. 2017 Apr 5;94(1):1-4. |
3. Veldman MB, Lin S. Stem cells on fire: inflammatory signaling in HSC emergence. |
4. Dev Cell. 2014 Dec 8;31(5):517-8. |
5. Veldman MB, Lin S. Zebrafish as a developmental model organism for pediatric research. Pediatr Res. 2008 Nov;64(5):470-6. Review. |
6. Senut MC, Fausett B, Veldman M, Goldman D. Gene regulation during axon and tissue regeneration in the retina of zebrafish. Model Organisms in Central Nervous System Regeneration. Becker CG and BeckerT (Eds.). Wiley-VCH. 2006. |
Abstracts |
1. Veldman MB, Dong HW, Yang XW. "Novel MORF mouse lines for Cre-dependent sparse labeling of genetically-defined single neurons." NIH BRAIN Initiative BICCC Technology Integration sub-workgroup, May 22, 2017. |
2. Veldman MB, Yang XW. "Novel knockin mouse lines for Cre-dependent sparse labeling of genetically-defined, single neurons for brainwide morphological analyses." UCLA Synapse to Circuit Club, May 12, 2017. |
3. Veldman MB. "Cell specification and reprogramming: How tissues develop and might be rebuilt." California State University Dominguez Hills, NIH MBRS (Minority Biomedical Research Support) Program Biological Research Seminar Series. October 1, 2015. |
4. Veldman MB, Zhao C, and Lin S. "Transdifferentiation of skeletal muscle cells into endothelium." UCLA Department of Biological Chemistry, Embryology Club. February 22, 2013. |
5. Veldman MB, Zhao C, and Lin S. "Transdifferentiation of fast skeletal muscle into |
6. endothelial cells by ectopic expression of etsrp/etv2." #44. 10th International Conference on Zebrafish Development and Genetics. Madison, WI. June 20-24, 2012. |
7. Veldman MB and Lin S. "Regulation of the etsrp/etv2 locus in the zebrafish vascular lineage." #790, 16th International Vascular Biology Meeting, June 20-24, 2010. |
8. Veldman MB and Goldman D. "Alpha-1 Tubulin, a cytoskeletal protein critical for central nervous system development and induced during optic nerve regeneration in the zebrafish, is transcriptionally regulated by a novel proximal enhancer." Prog.# 870.8. Society for Neuroscience. 2003. |
9. Veldman MB, Foster NN, Zhu M, Becerra M, Daigle TL, Zunega-Sanchez E, Zipursky SL, Zeng H, Dong HW, Yang XW. Novel MORF mouse lines for Cre-dependent, sparse labeling of genetically-defined single neurons for brainwide morphological analysis. 4th Annual BRAIN Initiative Investigators Meeting. North Bethesda, MD., April 9-11, 2018. |
10. Veldman MB, Foster NN, Zhu M, Becerra M, Daigle TL, Zunega-Sanchez E, Zipursky SL, Zeng H, Dong HW, Yang XW. A novel mouse genetic tool for Cre-dependent, sparse labeling of neurons for detailed morphological studies: applications to study the basal ganglia. Basal Ganglia Gordon Research Conference: Mechanisms Underlying Basal Ganglia Function and Dysfunction, Ventura, CA, March 11-16, 2018. |
11. Veldman MB, Foster NN, Zhu M, Becerra M, Daigle TL, Zeng H, Dong HW, Yang XW. Novel knockin mouse lines for Cre-depenent sparse labeling of genetically-defined, single neurons for brainwide morphological analyses. 2017 Society for Neuroscience, Washington D.C., November 13, 2017, 1:00 PM. #436.09. |
12. Veldman MB, Zhu M, Li R, Foster NN, Gu X, Daigle TL, Zeng H, Dong HW, Yang XW. Novel Mouse Models for Cre-dependent Sparse Labeling and Morphological Reconstruction of Genetically-defined Neurons. 3rd Annual BRAIN Initiative Investigators Meeting. North Bethesda, MD. December 12-14, 2016. |
13. Veldman MB, Gu X, Lu XH, Foster NN, Zhu M, Li R, Bowman I, Yamashita S, Dong HW, Yang XW. Novel Strategy for Genetically-directed Sparse Labeling and Manipulations of Mammalian Neurons. 2nd Annual BRAIN Initiative Investigators Meeting. North Bethesda, MD. December 10-11, 2015. |
14. Veldman MB, Zhao C, and Lin S. Direct transdifferentiation of skeletal muscle into endothelium. Poster #67. Gordon Conference: Vascular Cell Biology. Ventura, CA. January 27 - February 1, 2013. |
15. Veldman MB, Gomez GA, and Lin S. Upstream regulators and downstream effecters of Etsrp/Etv2 function in blood and vasculature. Poster #30. HEME-NET: Nonmalignant Hematology Research Network Meeting, NIDDK, February 23-24, 2012. |
16. Veldman MB and Lin S. Regulation of the etsrp/etv2 locus in the zebrafish vascular lineage. #790, poster M01, 16th International Vascular Biology Meeting, June 20-24, 2010. |
17. Veldman MB and Goldman D. An enhancer critical for developmental and optic nerve injury responsive expression from the pan-neuronal 1 tubulin promoter. 5th International Symposium on Organogenesis: Development and Disease, University of Michigan. May 17, 2003. |
18. Veldman MB and Goldman D. Identification and characterization of an enhancer residing in the neural-specific, developmental and regeneration dependant 1 tubulin promoter. 5th International Conference on Zebrafish Development and Genetics. June 12-16, 2002. |
19. Veldman MB and Goldman D. A Ras MAP kinase signal transduction pathway regulates expression from the neural-specific 1 tubulin promoter. 4th International Symposium on Organogenesis, University of Michigan. May 2001. |
