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CURRICULUM VITAE

Neil Hogg PhD
Associate Dean, Professor
Department of Biophysics

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/01/1983 - 06/01/1985 Bsc (Hons), University of Leeds, Leeds, United Kingdom
09/01/1988 - 06/01/1989 M.Sc., The University of Essex, Colchester, United Kingdom
09/01/1989 - 01/15/1993 Ph.D., The University of Essex, Colchester, United Kingdom (Supervisors: Michael T. Wilson, Victor M. Darley-Usmar)

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
01/30/1993 - 06/30/1996 Postdoctoral Fellow, Biophysics (Supervisor: Balaraman Kalyanaraman), Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226

FACULTY APPOINTMENTS:
06/30/1996 - 06/30/2002 Assistant Professor, Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
07/01/2002 - 06/30/2008 Associate Professor, Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
07/01/2008 - Present Professor (Tenure Granted 2009), Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226

ADMINISTRATIVE APPOINTMENTS:
2000 - 2016 Associate Director, Biophysics, Free Radical Research Center, 8701 Watertown Plank Rd, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2008 - Present Director, Redox Biology Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, 8701 Watertown Plank Rd, Milwaukee, WI 53226

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
1998 - 2000 Recruitment Director, Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2000 - 2013 Course Director, Biophysics, Medical College of Wisconsin, 8701 Watertown Plank, WI 53226
2000 - 2015 Graduate Program Director, Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2008 - 2010 Assistant Dean for Recruitment, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2010 - 2015 Assistant Dean of Students, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2014 - 2015 Interim Assistant Dean for Post-Doctoral Affairs, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2015 - 2019 Associate Dean of Students, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
2019 - Present Associate Dean of Academic Affairs, Graduate School of Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226

AWARDS AND HONORS:
1992 Young Investigator Award to attend the 5th Biennial Conference in Turin, Italy, Society for Free Radical Research (European section)
1993 Young Investigator Award to attend the 4th International Spin Trapping Conference in Oklahoma City, OK
1993 Young Investigator Award to attend the First Annual Meeting of the Oxygen Society in Charleston, SC, Oxygen Society
1994 Young Investigator Award to attend the 6th Biennial Conference of the Society for Free Radical Research in Sydney, Australia, Society for Free Radical Research
1995 Young Investigator Award to attend the Second Annual Conference of the Oxygen Society, Pasadena, CA, Oxygen Society
1999 Outstanding Volunteer Contribution Award, Oxygen Society
2008 Invited to present “Larry Piette Honorary Lecture” at the 50th Rocky Mountain EPR Conference, Breckinridge, CO
2015 Inducted as a Fellow, Society of Redox Biology and Medicine
2019 - 2020 Outstanding Graduate School Educator, Medical College of Wisconsin
2020 - 2021 Outstanding Graduate School Educator Pin, MCW School of Graduate Studies
2022 - Present Office of Academic Affairs Service Pin, Medical College of Wisconsin

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1993 - Present Society for Free Radical Research (Europe) (Member)
09/15/2022 - Present MCW Society of Teaching Scholars (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
05/01/2011 - 2021 Nitric Oxide: Biology and Chemistry
Editorial Board
1997 - 2003 Analytical Biochemistry
1998 - Present Free Radical Biology and Medicine
2003 - 2007 Chemical Research in Toxicology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1998 Ad Hoc Reviewer, MCND-2 Study Section, National Institutes of Health
2000 - 2004 Member, Pathophysiology 2 study section, American Heart Association
2002 - 2006 Elected Member, Council, Society for Redox Biology and Medicine
2005 Member, Organizing Committee, First International Conference on Nitrite, Bethesda, MD
2006 - 2008 Ad Hoc Member, Cancer Etiology Study Section, National Institutes of Health
2006 Member, Organizing Committee, 13th Annual Meeting of the Society of Redox Biology and Medicine, Denver CO
2006 Chair, Pre-meeting Workshop on “The thiol group in oxidative stress and redox signaling”, 13th Annual Meeting of the Society of Redox Biology and Medicine in Denver, CO
2007 Member, Organizing Committee, Second International Conference on Nitrite, Bethesda, MD
2008 Organizer, “EPR Spin-Trapping” Session, Rocky Mountain Conference, Breckinridge CO
2008 - 2013 Chartered Member, Cancer Etiology Study Section, National Institutes of Health
2010 - 2012 Elected Member (Second Term), Council, Society for Redox Biology and Medicine
2010 Member, Organizing Committee, 17th Annual Meeting of the Society of Redox Biology and Medicine, Orlando, FL
2012 - 2014 President Elect, Society for Redox Biology and Medicine
2012 Co-chair, Oxygen Radicals, Gordon Conference
2012 Co-organizer and Chair, Pre-meeting Workshop on Enabling technologies in Free Radical Research, 19th Annual Meeting of the Society of Redox Biology and Medicine, San Diego, CA
2015 - 2017 President, Society for Redox Biology and Medicine
2015 Co-chair, First MCW Redox Biology Symposium, Milwaukee, WI
2015 Chair, 22nd Annual Meeting of the Society of Redox Biology and Medicine, Boston, MA
2016 Chair, 23rd Annual Meeting of the Society of Redox Biology and Medicine, and the Society of Free Radical Research International, San Francisco, CA
2017 Co-chair, Gordon Research Conference on Nitric Oxide, Ventura, CA
2018 Co-chair, Second MCW Redox Biology Symposium
2019 Co-chair, Gordon Research Conference on Nitric Oxide, Ventura, CA
2021 - Present Co-Chair, 3rd Redox Biology Symposium, Medical College of Wisconsin

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Small molecule NO precursors as a bioactive source of NO in vasodilation and angiogenesis (R01 HL139557)
Source:
NIH/NHLBI
Role & Effort:
Co-Investigator
PI:
Lohr
Dates:
07/01/2019 - 05/31/2023
  
Title:
Biochemical mechanisms of beta-cell destruction (R01 DK052194)
Source:
NIH/NHLBI
Role & Effort:
Co-Investigator
PI:
Corbett
Dates:
07/17/2019 - 05/31/2022
  
Title:
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research (R01 GM140385)
Source:
NIH/NHLBI
Role & Effort:
Co-Investigator
PI:
Klug & Lerch
Dates:
01/01/2021 - 11/30/2024
  
Pending
Peer Review
Title:
Far Red Light to improve Functioning in PAD: the LIGHT PAD trial. (R21 AG080426). Received 6th percentile and funding notice imminent.
Source:
National Institute on Aging (NIA)
Role & Effort:
Co-PI
PI:
Mary McDermott
Dates:
12/01/2022 - 11/30/2024
  
Title:
ENhancing exercise with LIGHT to improve functioning in PAD: the ENLIGHTEN PAD trial (AG081627). - Received 8th percentile in the last cycle.
Source:
National Institute on Aging
Role & Effort:
Co-I
PI:
Mary McDermott
Dates:
06/2023 - 05/2025
  
Prior
Peer Review
Title:
Reactions between thiols, nitric oxide and peroxynitrite (R29 GM055792)
Source:
NIH/NIGMS
Role & Effort:
PI
PI:
Hogg
Dates:
04/01/1997 - 11/30/2001
  
Title:
Quantitative Electron Paramagnetic Spin-Trapping using Spectral Simulation
Source:
MCW Research Affairs Committee
Role & Effort:
PI
PI:
Hogg
Dates:
06/01/1997 - 05/31/1998
  
Title:
The effect of GSNO on apoptosis in MCF-7 cells
Source:
MCW Cancer Center
Role & Effort:
PI
PI:
Hogg
Dates:
01/01/2000 - 12/31/2000
  
Title:
Mechanisms of metabolism of S-nitrosothiols (R01 GM055792)
Source:
NIH/NIGMS
Role & Effort:
PI
PI:
Hogg
Dates:
12/10/2001 - 11/30/2005
  
Title:
Effects of Nitric Oxide in Sickle Cell Blood (R01 HL58091 converted to R37 [MERIT] in 2007 )
Source:
NIH/NHLBI
Role & Effort:
Sub-contract Investigator
PI:
Kim-Shapiro
Dates:
09/01/2002 - 04/30/2017
  
Title:
The formation and metabolism of s-nitrosothiols in vascular cells (Predoctoral Fellowship)
Source:
American Heart Association
Role & Effort:
Sponsor
Dates:
01/2003 - 12/2004
  
Title:
Summer Research Experiences for Undergraduates (R25 GM66966)
Source:
NIH/NIGMS
Role & Effort:
PI
PI:
Hogg
Dates:
05/01/2003 - 04/30/2007
  
Title:
Hemoglobin and Haptoglobin in Sickle Cell Disease
Source:
Advancement for a Healthier Wisconsin
Dates:
01/2006 - 01/2008
Direct Funds:
$15,000
  
Title:
Mechanism of metabolism of S-nitrosothiols (R01 GM055792)
Source:
NIH/NIGMS
Role & Effort:
PI
PI:
Hogg
Dates:
04/01/2007 - 03/31/2011
  
Title:
Midwest Basic and Translational Research Center for Sickle Cell Disease
Source:
NIH/NHLBI
Role & Effort:
Project Leader
Dates:
06/01/2008 - 05/31/2012
  
Title:
Mechanisms of Photobiomodulation in Myocardial Reperfusion Injury
Source:
NIH/NHLBI
Role & Effort:
Co-Investigator
PI:
Bienengraeber & Pratt
Dates:
06/15/2010 - 05/31/2014
  
Title:
Nitric Oxide: A modulator of bioenergetics in breast cancer
Source:
Wisconsin Breast Cancer Showhouse
Role & Effort:
PI
PI:
Hogg
Dates:
2012 - 2014
  
Title:
Development of a Redox Biology Program at the Medical College of Wisconsin
Source:
Advancing a Healthier Wisconsin
Role & Effort:
PI
PI:
Hogg
Dates:
2012 - 2018
Direct Funds:
$1,600,000
  
Title:
Nociceptive Mechanisms Underlying Sickle Cell Pain (R01 NS070711)
Source:
NIH/NINDS
Role & Effort:
Co-Investigator
PI:
Stucky/Hillery
Dates:
09/01/2013 - 08/31/2018
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
The production of hydroxyl radical from the simultaneous formation of nitric oxide and peroxynitrite, Joint Conference of SFRR Europe and the Society of Pulse Radiolysis, Manchester, England, 1991
The effect of lipid peroxidation on membrane permeability, Italian Conference of Bioenergetics, Rome, Italy, 1992
Nitric oxide and superoxide in atherosclerosis, Seminar given at the University of Rome at the invitation of Prof. M. Brunori, Rome, Italy, 1992
The kinetics of low-density lipoprotein oxidation analyzed by numerical methods, 5th Biennial Conference of SFRR International, Turin, Italy, 1992
Peroxynitrite formation from SIN-1, The London Iron Club Meeting, Royal Free Hospital, London, England, 1992
The inhibitory effects of nitric oxide on LDL oxidation, Seminar given at Wellcome Research Laboratories at the invitation of Dr. V. Darley-Usmar, Beckenham, Kent, 1993
Peroxynitrite and atherosclerosis, SFRR Europe Winter Meeting, Royal Free Hospital, London, England, 1993
S-Nitrosohemoglobin, Biological Reactive Intermediates VI, Paris, France, 2000
The reaction between S-nitrosothiols and hemoglobin, 5th Workshop on EPR applications in Biology and Medicine, Krakow, Poland, 2001
Post-processing EPR spin-trapping data, International EPR Spin Trapping Meeting, Chapel Hill, NC, 2002
Mechanistic re-examination of the reaction between nitrite and hemoglobin, 11th Annual meeting of the Society for Free Radicals in Biology and Medicine, St. Thomas, US Virgin Islands, 2002
Deoxyhemoglobin as a nitrite reductase, 4th International conference on porphyrins and phthalocyanines, Rome, Italy, 2006
Nitrosopersulfide, 2018 International Nitric Oxide Conference, Oxford, UK, 2018
NO and cancer cell Bioenergetics, Seminar at the invitation of Dr. Takaaki Akaike, Tohoku University, Sendai, Japan, 2019
Nitrosopersulfide, The 9th Biennial Meeting of Society for Free Radical Research-Asia, Kyoto International Community House (Kokoka), Kyoto, Japan, 2019
 
National
The inhibition of lipid peroxidation by nitric oxide, Seminar given at the University of Alabama at the invitation of Prof. B. Freeman, Birmingham, AL, 1993
The inhibition of lipid peroxidation by nitric oxide, First Biennial Meeting of the Oxygen Society, Charleston, SC, 1993
The reaction between nitric oxide and nitronyl nitroxide spin-trapping agents, Fourth International Spin Trapping Conference, Oklahoma Medical Research Foundation, Oklahoma City, OK, 1993
Free Radicals in Disease, 17th Annual International Gastroenterology Conference, Orlando, FL, 1996
Nitric oxide, peroxynitrite and vitamin E, Linus Pauling Institute, Corvallis, OR, 1997
The effect of thiols on the autoxidation of homocysteine, Experimental Biology 98, San Francisco, CA, 1998
S-Nitrosation and S-Thiolation of Creatine Kinase, 5th Annual Conference of the Oxygen Society, Washington, DC, 1998
The good side of NO, Annual meeting of the American Thoracic Society, San Diego, CA, 1999
Metabolism of S-Nitrosoglutathione by Endothelial Cells, 6th Annual Conference of the Oxygen Society, New Orleans, LA, 1999
The Antioxidant Activities of Nitric Oxide, 38th Annual meeting of the Society of Toxicology, New Orleans, LA, 1999
Mechanism of formation and uptake of S-nitrosothiols in macrophages, Invited Seminar at Wake Forest University, Winston-Salem, NC, 2002
Mechanism of S-nitrosothiols uptake into macrophages, Massilla Conference on Nitric Oxide, El Paso, NM, 2002
The not-so-simple reaction between nitrite and deoxyhemoglobin, 1st meeting of the Nitrite Tie Club, Bathesda, MD, 2002
The interaction between Nitric Oxide and Hemoglobin: Trashcan or recycling bin, American Chemical Society Meeting, Boston, MA, 2002
Post Processing EPR Spin-Trapping Data, Rocky Mountain Conference, Denver, CO, 2002
The transport of S-nitrosothiols and the S-nitrosation signaling paradigm, Invited seminar at the University of Alabama, Birmingham, AL, 2005
The reaction between nitrite and deoxyhemoglobin, NIH meeting on nitrite, Bethesda, MD, 2005
Protein modification by S-nitrosation, 4th International conference of the Nitric Oxide Society, Monterey, CA, 2006
The reaction of nitrite with oxy- and deoxy-hemoglobin, EPR2007: A Joint Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th International EPR Spin Trapping/Spin Labeling, Chicago, IL, 2007
Differential Regulation of Cellular Activities by NO and S-Nitrosothiols, Wake Forest Nitrogen Oxide Meeting, Farmington, PA, 2008
S-Nitrosocystein transport: A window on NO signaling in cells, Seminar at the invitation of Dr. Bruce A. Freeman at the Department of Pharmacology, University of Pittsburg, Pittsburgh, PA, 2008
The ABC’s of thiol chemistry, Oxygen Radical Gordon Conference, Ventura, CA, 2008
S-Nitrosation and NO signaling, Seminar at the invitation of Dr. Douglas Thomas at Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, 2009
S-Nitrosothiols: Synthesis and Signaling, Seminar at the invitation of Dr. Donald Becker at the Redox Biology Center, University of Nebraska, Lincoln, NE, 2009
S-Nitrosothiol transport: Insights into NO signaling mechanisms, Seminar at the invitation of Dr. David Jourd’heuil at Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, 2009
S-Nitrosothiol transport: Insights into NO signaling mechanisms, Seminar at the invitation of Dr. Victor Darley-Usmar at the Department of Pathology, University of Alabama, Birmingham, AL, 2009
S-Nitrosothiols: Synthesis and Signaling, Seminar at the invitation of Dr. Ming Xian, Department of Chemistry, Washington State University, Pullman, WA, 2009
Differential Effects of NO and S-Nitrosothiols on cellular bioenergetics, Seminar at the invitation of Dr. Yunfeng Zhao, Department of Toxicology, Louisiana State University Health Sciences Center, Shreveport, LA, 2010
Cell-free hemoglobin, lipid oxidation and nitric oxide in sickle cell disease, Annual Sickle Cell Disease Clinical Research Meeting, Bethesda, MD, 2010
Differential Effects of NO and S-Nitrosothiols on cellular bioenergetics, Seminar at the invitation of Dr. Xianglin Shi, Department of Toxicology, University of Kentucky, Lexington, KY, 2010
Redox Signaling through protein cysteine residues, Society of Free Radicals in Biology and Medicine Webinar Series, Virtual, 2010
S-Nitrosation of MCT in Cancer, Nitric Oxide Gordon Research Conference, Ventura CA, 2013
NO and Cancer Cell Proliferation, Jack R. Lancaster Retirement Symposium, University of Alabama, Birmingham, AL, 2013
NO and Cancer cell Bioenergetics, RePO Workshop, National Cancer Institute, NIH, Bethesda, MD, 2013
NO and cellular bioenergetics, University of Kentucky, Louisville, KY, 2015
 
Regional
Mechanism of formation and uptake of S-nitrosothiols in macrophages, Invited Seminar at University of Illinois, Chicago, IL, 2002
 
Local
Uncoupled nitric oxide synthase activity detected by ESR spin-trapping, 25th International Society of Oxygen transport to Tissue, Milwaukee, WI, 1997
Nitric Oxide, S-nitrosothiols and Hemoglobin, Department of Physiology Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 2001
Nitric Oxide and Hemoglobin, Department of Biochemistry Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 2002
S-Nitrosothiols as Transducers of Nitric Oxide Bioactivity, Free Radical Research Center Seminar, Medical College of Wisconsin, Milwaukee, WI, 2007
S-Nitrosation of Protein Thiols, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 2007
S-Nitrosothiols: Synthesis and Signaling, Seminar at the invitation of Dr. William Campbell, Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI, 2009
NO and Cancer Cell Bioenergetics, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 2013
 

COMMITTEE SERVICE:
Medical College of Wisconsin
1998 - Present Member, Graduate Studies Council, Graduate School, Medical College of Wisconsin
2000 - 2003 Chair, Curriculum and Programs Committee, Graduate School, Medical College of Wisconsin
2005 - 2006 Elected Member, Faculty Council, Biophysics, Medical College of Wisconsin
2005 - 2009 Chair, Admissions Committee, Interdisciplinary Program in Biomedical Sciences, Graduate School, Medical College of Wisconsin
2006 - 2013 Chair, Faculty Credentials Committee, Graduate School, Medical College of Wisconsin
2007 Member, Educational Strategic Plan Task Force, Medical College of Wisconsin
2009 - 2013 Member, Executive Evaluation Committee, Interdisciplinary Program in Biomedical Sciences, Graduate School, Medical College of Wisconsin
2012 - Present Member, Faculty Governance Committee, Medical College of Wisconsin
2012 - 2013 Vice President, Faculty Council, Medical College of Wisconsin
2012 - Present Member, Assessment Oversight Committee, Medical College of Wisconsin
2012 - 2013 Chair, Curriculum Committee, Interdisciplinary Program in Biomedical Sciences, Graduate School, Medical College of Wisconsin
2013 Member, Talent Development "EMERGE" process team, Medical College of Wisconsin
2013 - 2014 Member, Student Information Systems Planning Team, Medical College of Wisconsin
2013 - 2014 Senior Vice President, Faculty Council, Medical College of Wisconsin
2013 - Present Chair, Executive Evaluation Committee, Interdisciplinary Program in Biomedical Sciences, Graduate School, Medical College of Wisconsin
2014 - 2015 President, Faculty Council, Medical College of Wisconsin
2014 - 2015 Member, Associate Ombuds Search Committee, Medical College of Wisconsin
2015 Member, Department of Radiology Chair Search Committee, Medical College of Wisconsin
2015 - Present Member and Designated Deputy Title IX Coordinator, Title IX Steering Committee, Medical College of Wisconsin
2015 - 2017 Member, Joint Biomedical Engineering Department Steering Committee and Educational Experience Sub-committee, Medical College of Wisconsin
2015 Member, Review Panel for Presidential Scholar Awards, Medical College of Wisconsin
2015 - 2018 Ex-Officio Member, Professional Enrichment Committee, Medical College of Wisconsin
2015 Member, Chair Search Committee. Microbiology and Molecular Genetics, Medical College of Wisconsin
2017 - Present Parliamentarian, Faculty Council, Medical College of Wisconsin
2019 - 2022 Member, University Rank and Tenure Committee, Medical College of Wisconsin
2019 - 2022 Chair, Graduate School Rank Committee, Medical College of Wisconsin
2020 Chair, Ad Hoc Committee on Holistic Admissions, Graduate School, Medical College of Wisconsin
2021 - 2022 Member, Integrating Basic Science Curriculum Committee, Academic Affairs
01/2022 - Present Chair, Holistic Promotion and Tenure Review: Tenure Workgroup, Faculty Affairs, Medical College of Wisconsin
01/2022 - Present Member, Holistic Rank and Tenure Review: Pathways Workgroup, Faculty Affairs, Medical College of Wisconsin
2022 - Present Member, Fusion Curriculum Steering Committee, Academic Affairs, Medical College of Wisconsin
 

MCW TEACHING ACTIVITIES:
Medical Student Education
2011 - Present M1 Molecules to Cells Case-Based Discussion Class Facilitator
2016 - Present Lecturer, Molecules to Cells
2021 - Present Course Director: Molecules to Cells M1 course
08/2022 - Present Hematology/Immunology Block Director for the Fusion Curriculum
 
Graduate Student Education
2000 - 2013 Course Director, Biophysics Seminar
2000 - Present Teacher, Electron Paramagnetic Resonance
2000 - Present Course Director/Teacher, Free Radicals in Biology
2003 - Present Teacher, Biophysical Techniques in Biochemistry
2004 - 2019 Teacher, Biochemistry of the Cell
2007 - 2019 Teacher, Mechanisms of Cellular Signaling
2008 - Present Teacher, Advanced Enzyme Kinetics
2019 - Present Co-Course Director, Fundamentals of Biomedical Sciences I
2020 - Present Co-Course Director, Writing of a Scientific Paper
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Students Advised
08/1998 - 05/2003 Netanya Y. Spencer, S-Nitrosothiols, Nitric Oxide and Heme Proteins, Medical College of Wisconsin
08/2001 - 05/2005 Yanhong Zhang, The formation and transport of S-nitrosothiols, Medical College of Wisconsin
08/2003 - 08/2008 Katarzyna Broniowska, The effects of S-nitrosothiol transport on cell function, Medical College of Wisconsin
08/2004 - 07/2009 Nicholas J. Kettenhofen, Proteomic detection of S-nitrosothiols, Medical College of Wisconsin
08/2007 - 2012 Timothy Flewelen, Oxidative Stress in Sickle Cell Disease: The Contribution of Cell-Free Hemoglobin in Plasma, Medical College of Wisconsin
08/2008 - 2014 Ching-Fang Chang, Multifaceted Effects of NO on Breast Tumor Bioenergetics and Chemosensitivity, Medical College of Wisconsin
08/2008 - 2013 Zhen Ding, The Metabolism of S-Nitrosothiols and the Role of Nitric Oxide in Macrophage Activation, Medical College of Wisconsin
08/01/2011 - 2013 Michael Larson, Examining Phosphatidylethanolamine Externalization on Cells and Microparticles in Hemolysis and Hemolytic Anemia, Medical College of Wisconsin
 
Postdoctoral Researchers
10/2003 - 04/2005 Barbora Piknova, Advisor, Medical College of Wisconsin
08/2006 - 2016 Agnes Keszler, Advisor, Medical College of Wisconsin
08/2008 - 12/31/2011 Katarzyna Broniowska, Advisor, Medical College of Wisconsin
06/2009 - 09/2013 Madelyn Hanson, Advisor, Medical College of Wisconsin
03/2010 - 05/2013 Anne Diers, Advisor, Medical College of Wisconsin
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Wilson MT, Hogg N, Jones GD. Reactions of reduced cellobiose oxidase with oxygen. Is cellobiose oxidase primarily an oxidase? Biochem J. 1990 Aug 15;270(1):265-7. PMCID: PMC1131709
2. Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J. 1992 Jan 15;281 ( Pt 2)(Pt 2):419-24. PMCID: PMC1130701
3. Darley-Usmar VM, Hogg N, O'Leary VJ, Wilson MT, Moncada S. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Radic Res Commun. 1992;17(1):9-20.
4. Diers AR, Broniowska KA, Darley-Usmar VM, Hogg N. Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H803-12. PMCID: PMC3191094
5. Broniowska KA, Keszler A, Basu S, Kim-Shapiro DB, Hogg N. Cytochrome c-mediated formation of S-nitrosothiol in cells. Biochem J. 2012 Feb 15;442(1):191-7. PMCID: PMC3943432
6. Goss SP, Hogg N, Kalyanaraman B. The antioxidant effect of spermine NONOate in human low-density lipoprotein. Chem Res Toxicol. 1995;8(5):800-6.
7. Tejero J, Basu S, Helms C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT. Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin. J Biol Chem. 2012 May 25;287(22):18262-74. PMCID: PMC3365727
8. Hogg N, Struck A, Goss SP, Santanam N, Joseph J, Parthasarathy S, Kalyanaraman B. Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors. J Lipid Res. 1995 Aug;36(8):1756-62.
9. Kalyanaraman B, Darley-Usmar V, Struck A, Hogg N, Parthasarathy S. Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. J Lipid Res. 1995 May;36(5):1037-45.
10. Diers AR, Broniowska KA, Chang CF, Hogg N. Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition. Biochem J. 2012 Jun 15;444(3):561-71. PMCID: PMC4898201
11. Struck AT, Hogg N, Thomas JP, Kalyanaraman B. Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells. FEBS Lett. 1995 Mar 20;361(2-3):291-4.
12. Singh RJ, Hogg N, Neese F, Joseph J, Kalyanaraman B. Trapping of nitric oxide formed during photolysis of sodium nitroprusside in aqueous and lipid phases: an electron spin resonance study. Photochem Photobiol. 1995 Apr;61(4):325-30.
13. Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B. Spin-labeling study of the oxidative damage to low-density lipoprotein. Arch Biochem Biophys. 1995 Jun 20;320(1):155-61.
14. Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B. Physical and chemical interactions between nitric oxide and nitroxides. Biochim Biophys Acta. 1994 Dec 15;1201(3):437-41.
15. Singh RJ, Hogg N, Joseph J, Kalyanaraman B. Photosensitized decomposition of S-nitrosothiols and 2-methyl-2-nitrosopropane. Possible use for site-directed nitric oxide production. FEBS Lett. 1995 Feb 20;360(1):47-51.
16. Hogg N, Singh RJ, Joseph J, Neese F, Kalyanaraman B. Reactions of nitric oxide with nitronyl nitroxides and oxygen: prediction of nitrite and nitrate formation by kinetic simulation. Free Radic Res. 1995 Jan;22(1):47-56.
17. Hogg N, Joseph J, Kalyanaraman B. The oxidation of alpha-tocopherol and trolox by peroxynitrite. Arch Biochem Biophys. 1994 Oct;314(1):153-8.
18. Hogg N, Rice-Evans C, Darley-Usmar V, Wilson MT, Paganga G, Bourne L. The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDL. Arch Biochem Biophys. 1994 Oct;314(1):39-44.
19. Sarti P, Hogg N, Darley-Usmar VM, Sanna MT, Wilson MT. The oxidation of cytochrome-c oxidase vesicles by hemoglobin. Biochim Biophys Acta. 1994 Sep 21;1208(1):38-44.
20. Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S. Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. FEBS Lett. 1993 Nov 15;334(2):170-4.
21. Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S. Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett. 1993 Sep 13;330(2):181-5.
22. Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide. FEBS Lett. 1993 Jul 12;326(1-3):199-203.
23. Singh RJ, Hogg N, Kalyanaraman B. Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. Arch Biochem Biophys. 1995 Dec 20;324(2):367-73.
24. Hogg N, Singh RJ, Kalyanaraman B. The role of glutathione in the transport and catabolism of nitric oxide. FEBS Lett. 1996 Mar 18;382(3):223-8.
25. Karoui H, Hogg N, Fréjaville C, Tordo P, Kalyanaraman B. Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. J Biol Chem. 1996 Mar 15;271(11):6000-9.
26. Karoui H, Hogg N, Joseph J, Kalyanaraman B. Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study. Arch Biochem Biophys. 1996 Jun 01;330(1):115-24.
27. Singh RJ, Hogg N, Joseph J, Kalyanaraman B. Mechanism of nitric oxide release from S-nitrosothiols. J Biol Chem. 1996 Aug 02;271(31):18596-603.
28. Hogg N, Singh RJ, Goss SP, Kalyanaraman B. The reaction between nitric oxide and alpha-tocopherol: a reappraisal. Biochem Biophys Res Commun. 1996 Jul 25;224(3):696-702.
29. Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B. Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett. 1997 Feb 17;403(2):127-30.
30. Hogg N, Singh RJ, Konorev E, Joseph J, Kalyanaraman B. S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. Biochem J. 1997 Apr 15;323 ( Pt 2)(Pt 2):477-81. PMCID: PMC1218344
31. Ferguson E, Singh RJ, Hogg N, Kalyanaraman B. The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein. Arch Biochem Biophys. 1997 May 15;341(2):287-94.
32. Goss SP, Hogg N, Kalyanaraman B. The effect of nitric oxide release rates on the oxidation of human low density lipoprotein. J Biol Chem. 1997 Aug 22;272(34):21647-53.
33. Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B. Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7.
34. O'Donnell VB, Chumley PH, Hogg N, Bloodsworth A, Darley-Usmar VM, Freeman BA. Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol. Biochemistry. 1997 Dec 09;36(49):15216-23.
35. Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr. Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3469-74.
36. Konorev EA, Hogg N, Kalyanaraman B. Rapid and irreversible inhibition of creatine kinase by peroxynitrite. FEBS Lett. 1998 May 08;427(2):171-4.
37. Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A. 1998 Aug 04;95(16):9220-5. PMCID: PMC21319
38. Singh RJ, Hogg N, Joseph J, Konorev E, Kalyanaraman B. The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. Arch Biochem Biophys. 1999 Jan 15;361(2):331-9.
39. Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B. Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. Methods Enzymol. 1999;301:169-77.
40. Goss SP, Kalyanaraman B, Hogg N. Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. Methods Enzymol. 1999;301:444-53.
41. Goss SP, Hogg N, Kalyanaraman B. The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. Arch Biochem Biophys. 1999 Mar 15;363(2):333-40.
42. Ferguson E, Hogg N, Antholine WE, Joseph J, Singh RJ, Parthasarathy S, Kalyanaraman B. Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. Free Radic Biol Med. 1999 Apr;26(7-8):968-77.
43. Patel RP, Hogg N, Spencer NY, Kalyanaraman B, Matalon S, Darley-Usmar VM. Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. J Biol Chem. 1999 May 28;274(22):15487-92.
44. Hogg N. The kinetics of S-transnitrosation--a reversible second-order reaction. Anal Biochem. 1999 Aug 01;272(2):257-62.
45. Hogg N. The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radic Biol Med. 1999 Jul;27(1-2):28-33.
46. Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J Biol Chem. 1999 Sep 17;274(38):26736-42.
47. Singh RJ, Hogg N, Goss SP, Antholine WE, Kalyanaraman B. Mechanism of superoxide dismutase/H(2)O(2)-mediated nitric oxide release from S-nitrosoglutathione--role of glutamate. Arch Biochem Biophys. 1999 Dec 01;372(1):8-15.
48. Konorev EA, Kalyanaraman B, Hogg N. Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation. Free Radic Biol Med. 2000 Jun 01;28(11):1671-8.
49. Spencer NY, Zeng H, Patel RP, Hogg N. Reaction of S-nitrosoglutathione with the heme group of deoxyhemoglobin. J Biol Chem. 2000 Nov 24;275(47):36562-7.
50. Kotamraju S, Hogg N, Joseph J, Keefer LK, Kalyanaraman B. Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. J Biol Chem. 2001 May 18;276(20):17316-23.
51. Zeng H, Spencer NY, Hogg N. Metabolism of S-nitrosoglutathione by endothelial cells. Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H432-9.
52. Zhang H, Joseph J, Feix J, Hogg N, Kalyanaraman B. Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution. Biochemistry. 2001 Jun 26;40(25):7675-86.
53. Vásquez-Vivar J, Whitsett J, Martásek P, Hogg N, Kalyanaraman B. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic Biol Med. 2001 Oct 15;31(8):975-85.
54. Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B, Parks DA, Barnes S, Darley-Usmar V. Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. Free Radic Biol Med. 2001 Dec 15;31(12):1570-81.
55. Zhang Y, Hogg N. Mixing artifacts from the bolus addition of nitric oxide to oxymyoglobin: implications for S-nitrosothiol formation. Free Radic Biol Med. 2002 Jun 01;32(11):1212-9.
56. Novalija E, Varadarajan SG, Camara AK, An J, Chen Q, Riess ML, Hogg N, Stowe DF. Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts. Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H44-52.
57. Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO 3rd, Schechter AN, Gladwin MT. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med. 2002 Dec;8(12):1383-9.
58. Zhang H, Bhargava K, Keszler A, Feix J, Hogg N, Joseph J, Kalyanaraman B. Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications. J Biol Chem. 2003 Mar 14;278(11):8969-78.
59. Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP. Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. Free Radic Biol Med. 2003 Apr 01;34(7):892-907.
60. Xu X, Cho M, Spencer NY, Patel N, Huang Z, Shields H, King SB, Gladwin MT, Hogg N, Kim-Shapiro DB. Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11303-8. PMCID: PMC208752
61. Keszler A, Kalyanaraman B, Hogg N. Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. Free Radic Biol Med. 2003 Nov 01;35(9):1149-57.
62. Novalija E, Hogg N, Kevin LG, Camara AK, Stowe DF. Ischemic preconditioning: triggering role of nitric oxide-derived oxidants in isolated hearts. J Cardiovasc Pharmacol. 2003 Nov;42(5):593-600.
63. Spencer NY, Patel NK, Keszler A, Hogg N. Oxidation and nitrosylation of oxyhemoglobin by S-nitrosoglutathione via nitroxyl anion. Free Radic Biol Med. 2003 Dec 01;35(11):1515-26.
64. Zhang Y, Hogg N. Formation and stability of S-nitrosothiols in RAW 264.7 cells. Am J Physiol Lung Cell Mol Physiol. 2004 Sep;287(3):L467-74.
65. Zhang Y, Hogg N. The mechanism of transmembrane S-nitrosothiol transport. Proc Natl Acad Sci U S A. 2004 May 25;101(21):7891-6. PMCID: PMC419527
66. Crawford JH, Chacko BK, Pruitt HM, Piknova B, Hogg N, Patel RP. Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease. Blood. 2004 Sep 01;104(5):1375-82.
67. Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH. Impact of pulmonary arterial endothelial cells on duroquinone redox status. Free Radic Biol Med. 2004 Jul 01;37(1):86-103.
68. Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT. Biological activity of nitric oxide in the plasmatic compartment. Proc Natl Acad Sci U S A. 2004 Aug 03;101(31):11477-82. PMCID: PMC509225
69. Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE. Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H175-84.
70. Everson CA, Laatsch CD, Hogg N. Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R374-83.
71. Kim-Shapiro DB, Gladwin MT, Patel RP, Hogg N. The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. J Inorg Biochem. 2005 Jan;99(1):237-46.
72. Zhang Y, Keszler A, Broniowska KA, Hogg N. Characterization and application of the biotin-switch assay for the identification of S-nitrosated proteins. Free Radic Biol Med. 2005 Apr 01;38(7):874-81.
73. Schopfer FJ, Baker PR, Giles G, Chumley P, Batthyany C, Crawford J, Patel RP, Hogg N, Branchaud BP, Lancaster JR Jr, Freeman BA. Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. J Biol Chem. 2005 May 13;280(19):19289-97.
74. Huang KT, Keszler A, Patel N, Patel RP, Gladwin MT, Kim-Shapiro DB, Hogg N. The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry. J Biol Chem. 2005 Sep 02;280(35):31126-31.
75. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005 May;115(5):1232-40. PMCID: PMC1077170
76. Jeffers A, Xu X, Huang KT, Cho M, Hogg N, Patel RP, Kim-Shapiro DB. Hemoglobin mediated nitrite activation of soluble guanylyl cyclase. Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):130-5.
77. Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, Huang KT, Ho C, Hogg N, Schechter AN, Gladwin MT. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest. 2005 Aug;115(8):2099-107. PMCID: PMC1177999
78. Piknova B, Gladwin MT, Schechter AN, Hogg N. Electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during NO inhalation. J Biol Chem. 2005 Dec 09;280(49):40583-8.
79. Azarov I, Huang KT, Basu S, Gladwin MT, Hogg N, Kim-Shapiro DB. Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation. J Biol Chem. 2005 Nov 25;280(47):39024-32.
80. Keszler A, Mason RP, Hogg N. Immuno-spin trapping of hemoglobin and myoglobin radicals derived from nitrite-mediated oxidation. Free Radic Biol Med. 2006 Feb 01;40(3):507-15.
81. Broniowska KA, Zhang Y, Hogg N. Requirement of transmembrane transport for S-nitrosocysteine-dependent modification of intracellular thiols. J Biol Chem. 2006 Nov 10;281(45):33835-41. PMCID: PMC1839924
82. Shiva S, Wang X, Ringwood LA, Xu X, Yuditskaya S, Annavajjhala V, Miyajima H, Hogg N, Harris ZL, Gladwin MT. Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Nat Chem Biol. 2006 Sep;2(9):486-93.
83. Grubina R, Huang Z, Shiva S, Joshi MS, Azarov I, Basu S, Ringwood LA, Jiang A, Hogg N, Kim-Shapiro DB, Gladwin MT. Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. J Biol Chem. 2007 Apr 27;282(17):12916-27.
84. Hogg N, Broniowska KA, Novalija J, Kettenhofen NJ, Novalija E. Role of S-nitrosothiol transport in the cardioprotective effects of S-nitrosocysteine in rat hearts. Free Radic Biol Med. 2007 Oct 01;43(7):1086-94.
85. Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N. Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol. 2007 Oct;43(4):437-44. PMCID: PMC2735077
86. Jiang J, Corbett J, Hogg N, Mason RP. An electron paramagnetic resonance investigation of the oxygen dependence of the arterial-venous gradient of nitrosyl hemoglobin in blood circulation. Free Radic Biol Med. 2007 Oct 15;43(8):1208-15. PMCID: PMC2030993
87. Basu S, Grubina R, Huang J, Conradie J, Huang Z, Jeffers A, Jiang A, He X, Azarov I, Seibert R, Mehta A, Patel R, King SB, Hogg N, Ghosh A, Gladwin MT, Kim-Shapiro DB. Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. Nat Chem Biol. 2007 Dec;3(12):785-94.
88. Keszler A, Piknova B, Schechter AN, Hogg N. The reaction between nitrite and oxyhemoglobin: a mechanistic study. J Biol Chem. 2008 Apr 11;283(15):9615-22. PMCID: PMC2442280
89. Wang X, Kettenhofen NJ, Shiva S, Hogg N, Gladwin MT. Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins. Free Radic Biol Med. 2008 Apr 01;44(7):1362-72. PMCID: PMC2396494
90. Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ. Vascular dysfunction in a murine model of severe hemolysis. Blood. 2008 Jul 15;112(2):398-405. PMCID: PMC2442749
91. Kettenhofen NJ, Wang X, Gladwin MT, Hogg N. In-gel detection of S-nitrosated proteins using fluorescence methods. Methods Enzymol. 2008;441:53-71. PMCID: PMC2673541
92. Basu S, Azarova NA, Font MD, King SB, Hogg N, Gladwin MT, Shiva S, Kim-Shapiro DB. Nitrite reductase activity of cytochrome c. J Biol Chem. 2008 Nov 21;283(47):32590-7. PMCID: PMC2583304
93. Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide. 2009 Mar;20(2):88-94. PMCID: PMC2698998
94. Sampath V, Radish AC, Eis AL, Broniowska K, Hogg N, Konduri GG. Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia. Free Radic Biol Med. 2009 Mar 01;46(5):663-71. PMCID: PMC2646363
95. Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009 Aug;47(2):256-63. PMCID: PMC4329292
96. Riego JA, Broniowska KA, Kettenhofen NJ, Hogg N. Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L. Free Radic Biol Med. 2009 Aug 01;47(3):269-74. PMCID: PMC2704003
97. Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, Kalyanaraman B. Decreased S-nitrosation of peptide thiols in the membrane interior. Free Radic Biol Med. 2009 Oct 01;47(7):962-8. PMCID: PMC2874255
98. Keszler A, Zhang Y, Hogg N. Reaction between nitric oxide, glutathione, and oxygen in the presence and absence of protein: How are S-nitrosothiols formed? Free Radic Biol Med. 2010 Jan 01;48(1):55-64. PMCID: PMC2829852
99. Basu S, Keszler A, Azarova NA, Nwanze N, Perlegas A, Shiva S, Broniowska KA, Hogg N, Kim-Shapiro DB. A novel role for cytochrome c: Efficient catalysis of S-nitrosothiol formation. Free Radic Biol Med. 2010 Jan 15;48(2):255-63. PMCID: PMC2818408
100. Goetz BI, Shields HW, Basu S, Wang P, King SB, Hogg N, Gladwin MT, Kim-Shapiro DB. An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin. Nitric Oxide. 2010 Feb 15;22(2):149-54. PMCID: PMC2819623
101. Broniowska KA, Hogg N. Differential mechanisms of inhibition of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosothiols and NO in cellular and cell-free conditions. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1212-9. PMCID: PMC2957357
102. Ahmed MN, Codipilly C, Hogg N, Auten RL. The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress. Exp Lung Res. 2011 Feb;37(1):10-7.
103. Hanson MS, Piknova B, Keszler A, Diers AR, Wang X, Gladwin MT, Hillery CA, Hogg N. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Br J Haematol. 2011 Aug;154(4):502-11. PMCID: PMC3145810
104. Low NO concentration-dependence of the reductive nitrosylation reaction of hemoglobin. (Tejero J, Basu S, Helms C, Hogg N, King SB, Kim-Shapiro DB, Gladwin MT) J Biol Chem 2012 Apr 4:
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106. Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells. (Diers AR, Broniowska KA, Darley-Usmar VM, Hogg N) Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H803-12
107. Cortese-Krott MM, Rodriguez-Mateos A, Sansone R, Kuhnle GG, Thasian-Sivarajah S, Krenz T, Horn P, Krisp C, Wolters D, Heiß C, Kröncke KD, Hogg N, Feelisch M, Kelm M. Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood. 2012 Nov 15;120(20):4229-37.
108. Larson MC, Luthi MR, Hogg N, Hillery CA. Calcium-phosphate microprecipitates mimic microparticles when examined with flow cytometry. Cytometry A. 2013 Feb;83(2):242-50. PMCID: PMC3615643
109. Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ. A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H328-36. PMCID: PMC3543667
110. Broniowska KA, Diers AR, Corbett JA, Hogg N. Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. Biochemistry. 2013 Jun 25;52(25):4364-72. PMCID: PMC4028014
111. Menden H, Tate E, Hogg N, Sampath V. LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L445-55. PMCID: PMC3602745
112. Diers AR, Broniowska KA, Hogg N. Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells. Redox Biol. 2013;1(1):1-7. PMCID: PMC3757685
113. Diers AR, Keszler A, Hogg N. Detection of S-nitrosothiols. Biochim Biophys Acta. 2014 Feb;1840(2):892-900. PMCID: PMC4465751
114. Diers AR, Broniowska KA, Chang CF, Hill RB, Hogg N. S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells. Free Radic Biol Med. 2014 Apr;69:229-38. PMCID: PMC3982622
115. Larson MC, Hillery CA, Hogg N. Circulating membrane-derived microvesicles in redox biology. Free Radic Biol Med. 2014 Aug;73:214-28. PMCID: PMC4465756
116. Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, Guo Y, Mickelson B, Hillery CA, Lykotrafitis G, Low PS, Hogg N. Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cells Mol Dis. 2015 Feb;54(2):183-8. PMCID: PMC4297559
117. Chang CF, Diers AR, Hogg N. Cancer cell metabolism and the modulating effects of nitric oxide. Free Radic Biol Med. 2015 Feb;79:324-36. PMCID: PMC5275750
118. Xu H, Wandersee NJ, Guo Y, Jones DW, Holzhauer SL, Hanson MS, Machogu E, Brousseau DC, Hogg N, Densmore JC, Kaul S, Hillery CA, Pritchard KA Jr. Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation. Blood. 2014 Dec 18;124(26):3978-81. PMCID: PMC4271182
119. Everson CA, Henchen CJ, Szabo A, Hogg N. Cell injury and repair resulting from sleep loss and sleep recovery in laboratory rats. Sleep. 2014 Dec 01;37(12):1929-40. PMCID: PMC4548518
120. Kropp EM, Oleson BJ, Broniowska KA, Bhattacharya S, Chadwick AC, Diers AR, Hu Q, Sahoo D, Hogg N, Boheler KR, Corbett JA, Gundry RL. Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl Med. 2015 May;4(5):483-93. PMCID: PMC4414215
121. Oleson BJ, Broniowska KA, Naatz A, Hogg N, Tarakanova VL, Corbett JA. Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. Mol Cell Biol. 2016 Aug 01;36(15):2067-77. PMCID: PMC4946431
122. Wajih N, Liu X, Shetty P, Basu S, Wu H, Hogg N, Patel RP, Furdui CM, Kim-Shapiro DB. The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose. Redox Biol. 2016 Aug;8:415-21. PMCID: PMC4864376
123. Larson MC, Karafin MS, Hillery CA, Hogg N. Phosphatidylethanolamine is progressively exposed in RBCs during storage. Transfus Med. 2017 Apr;27(2):136-141. PMCID: PMC6152916
124. Keszler A, Diers AR, Ding Z, Hogg N. Thiolate-based dinitrosyl iron complexes: Decomposition and detection and differentiation from S-nitrosothiols. Nitric Oxide. 2017 May 01;65:1-9. PMCID: PMC5663227
125. Fahey JM, Emmer JV, Korytowski W, Hogg N, Girotti AW. Antagonistic Effects of Endogenous Nitric Oxide in a Glioblastoma Photodynamic Therapy Model. Photochem Photobiol. 2016 Nov;92(6):842-853. PMCID: PMC5161550
126. Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL. Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model. Free Radic Biol Med. 2017 Dec;113:157-164. PMCID: PMC5699925
127. van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. Rust never sleeps: The continuing story of the Iron Bolt. Free Radic Biol Med. 2018 Aug 20;124:353-357.
128. Keszler A, Lindemer B, Hogg N, Weihrauch D, Lohr NL. Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light. Arch Biochem Biophys. 2018 Jul 01;649:47-52.
129. Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL. Corrigendum to "Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model" [Free Radic. Biol. Med. 113:157-164]. Free Radic Biol Med. 2019 Feb 01;131:443.
130. Keszler A, Lindemer B, Hogg N, Lohr NL. Ascorbate attenuates red light mediated vasodilation: Potential role of S-nitrosothiols. Redox Biol. 2019 Jan;20:13-18. PMCID: PMC6156744
131. Oleson BJ, Broniowska KA, Yeo CT, Flancher M, Naatz A, Hogg N, Tarakanova VL, Corbett JA. The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide. Mol Cell Biol. 2019 Sep 15;39(18). PMCID: PMC6712938
132. Kim-Shapiro DB, Gladwin MT, Patel RP, Hogg N. The reaction between nitrite and hemoglobin. the role of nitrite in hemoglobin-mediated hypoxic vasodilation The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. 2008:269-289.
133. Zhang Y, Hogg N. S-Nitrosation of Cysteine Thiols as a Redox Signal Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. 19 June 2006:169-188.
134. Goetz BI, Wang P, Shields HW, Basu S, Grubina R, Huang J, Conradie J, Huang Z, Jeffers A, Jiang A, He X, Azarov I, Seibert R, Mehta A, Patel R, King SB, Ghosh A, Hogg N, Gladwin MT, Kim-Shapiro DB. Reply to 'Nitrite-methemoglobin inadequate for hypoxic vasodilation' Nature Chemical Biology. June 2009;5(6):367.
135. Keszler A, Kalyanaraman B, Hogg N. Erratum: Comparative investigation of superoxide trapping by cyclic nitrone spin traps: The use of singular value decomposition and multiple linear regression analysis (Free Radical Biology and Medicine (2003) 35 (1149-1157)) Free Radical Biology and Medicine. 1 January 2004;36(1):131.
136. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, Lundberg JO. Erratum: The emerging biology of the nitrite anion (Nature Chemical Biology (2005) 1, (308-314)) Nature Chemical Biology. February 2006;2(2):110.
137. Quesnelle K, Guimaraes DA, Rao K, Singh AB, Wang Y, Hogg N, Shiva S. Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation. Nitric Oxide. 2020 Nov 01;104-105:36-43. PMCID: PMC7606822
138. Stancill JS, Happ JT, Broniowska KA, Hogg N, Corbett JA. Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite. Am J Physiol Regul Integr Comp Physiol. 2020 May 01;318(5):R1004-R1013. PMCID: PMC7272767
139. Larson MC, Hogg N, Hillery CA. Centrifugation Removes a Population of Large Vesicles, or "Macroparticles," Intermediate in Size to RBCs and Microvesicles. Int J Mol Sci. 2021 Jan 27;22(3). PMCID: PMC7865243
140. Mokry RL, Schumacher ML, Hogg N, Terhune SS. Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection. mBio. 2020 Dec 15;11(6). PMCID: PMC7773989
141. Teng RJ, Jing X, Martin DP, Hogg N, Haefke A, Konduri GG, Day BW, Naylor S, Pritchard KA Jr. N-acetyl-lysyltyrosylcysteine amide, a novel systems pharmacology agent, reduces bronchopulmonary dysplasia in hyperoxic neonatal rat pups. Free Radic Biol Med. 2021 Apr;166:73-89. PMCID: PMC8009865
142. Rarick KR, Li K, Teng RJ, Jing X, Martin DP, Xu H, Jones DW, Hogg N, Hillery CA, Garcia G, Day BW, Naylor S, Pritchard KA Jr. Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease. Free Radic Biol Med. 2024 Mar;215:112-126. PMCID: PMC11290318
143. Naatz A, Yeo CT, Hogg N, Corbett JA. β-Cell-selective regulation of gene expression by nitric oxide. Am J Physiol Regul Integr Comp Physiol. 2024 Jun 01;326(6):R552-R566. PMCID: PMC11381020
 
Books, Chapters, and Reviews
1. Hogg N, Darley-Usmar VM, Graham A, Moncada S. Peroxynitrite and atherosclerosis. Biochem Soc Trans. 1993 May;21(2):358-62.
2. Hogg N, Kalyanaraman B. Nitric oxide and low-density lipoprotein oxidation. Free Radic Res. 1998 Jun;28(6):593-600.
3. Hogg N. Free radicals in disease. Semin Reprod Endocrinol. 1998;16(4):241-8.
4. Hogg N, Kalyanaraman B. Nitric oxide and lipid peroxidation. Biochim Biophys Acta. 1999 May 05;1411(2-3):378-84.
5. Goss SP, Singh RJ, Hogg N, Kalyanaraman B. Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications. Free Radic Res. 1999 Dec;31(6):597-606.
6. Broniowska KA, Hogg N. The chemical biology of S-nitrosothiols. Antioxid Redox Signal. 2012 Oct 01;17(7):969-80. PMCID: PMC3411335
7. Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B. Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. Free Radic Res. 1999 Dec;31(6):607-17.
8. Hogg N, Kalyanaraman B. The use of NO gas in biological systems. Methods Mol Biol. 1998;100:231-6.
9. Hogg N. Biological chemistry and clinical potential of S-nitrosothiols. Free Radic Biol Med. 2000 May 15;28(10):1478-86.
10. Hogg N. The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol. 2002;42:585-600.
11. Zhang Y, Hogg N. S-nitrosohemoglobin: a biochemical perspective. Free Radic Biol Med. 2004 Apr 15;36(8):947-58.
12. Zhang Y, Hogg N. S-Nitrosothiols: cellular formation and transport. Free Radic Biol Med. 2005 Apr 01;38(7):831-8.
13. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR Jr, Feelisch M, Lundberg JO. The emerging biology of the nitrite anion. Nat Chem Biol. 2005 Nov;1(6):308-14.
14. Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, Patel RP. Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2026-35.
15. Kettenhofen NJ, Broniowska KA, Keszler A, Zhang Y, Hogg N. Proteomic methods for analysis of S-nitrosation. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 15;851(1-2):152-9. PMCID: PMC1997299
16. Hogg N. Red meat and colon cancer: heme proteins and nitrite in the gut. A commentary on "diet-induced endogenous formation of nitroso compounds in the GI tract". Free Radic Biol Med. 2007 Oct 01;43(7):1037-9.
17. van Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, Kozlov AV, Li H, Lundberg JO, Mason R, Nohl H, Rassaf T, Samouilov A, Slama-Schwok A, Shiva S, Vanin AF, Weitzberg E, Zweier J, Gladwin MT. Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev. 2009 Sep;29(5):683-741. PMCID: PMC2725214
18. Hogg N. Detection of nitric oxide by electron paramagnetic resonance spectroscopy. Free Radic Biol Med. 2010 Jul 15;49(2):122-9. PMCID: PMC2916063
19. Patel RP, Hogg N, Kim-Shapiro DB. The potential role of the red blood cell in nitrite-dependent regulation of blood flow. Cardiovasc Res. 2011 Feb 15;89(3):507-15. PMCID: PMC3028972
20. The Chemical Biology of S-Nitrosothiols. (Hogg N, Broniowska KA) Antioxid Redox Signal 2012 Apr 2:
21. Broniowska KA, Diers AR, Hogg N. S-nitrosoglutathione. Biochim Biophys Acta. 2013 May;1830(5):3173-81. PMCID: PMC3679660
22. Hogg N, Zielonka J, Kalyanaraman B. Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review Nitric Oxide: Biology and Pathobiology: Third Edition. 1 January 2017:23-44.
 
Editorials, Letters To Editor, Other
1. Kim-Shapiro DB, Patel RP, Schechter AN, Gladwin MT, Cannon RO 3rd, Hogg N. How do red blood cells dilate blood vessels?--Reply. Circ Res. 2004 Aug 06;95(3):e10.
2. Gladwin MT, Wang X, Hogg N. Methodological vexation about thiol oxidation versus S-nitrosation -- a commentary on "An ascorbate-dependent artifact that interferes with the interpretation of the biotin-switch assay". Free Radic Biol Med. 2006 Aug 15;41(4):557-61.
3. Hogg N. Nitric oxide expands scope to cover hydrogen sulfide and carbon monoxide. Nitric Oxide. 2013 Nov 30;35:1.
 
Patents
1. U.S. Patent No. 8,143,420 (issued March 27, 2012) / MCW Tech ID: C1544. Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof. Inventors: Micael Hardy, Neil Hogg, Balaraman Kalyanaraman, Marcos Lopez, Olivier Ouari, Paul Tordo