CURRICULUM VITAE
Nikki K. Lytle PhD
Nikki K. Lytle PhD
Assistant Professor
Department of Surgery
Division of Surgical Oncology
Department of Surgery
Division of Surgical Oncology
OFFICE ADDRESS: |
Clinical Cancer Center |
9200 W Wisconsin Ave |
Milwaukee, WI 53226 |
EDUCATION: |
09/01/2006 - 05/01/2010 Bachelor of Arts, Willamette University, Salem, OR |
09/01/2012 - 09/01/2018 PhD, University of California, San Diego, La Jolla, CA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
11/01/2018 - 09/30/2022 Postdoctoral Fellow, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA |
FACULTY APPOINTMENTS: |
10/01/2022 - Present Assistant Professor, Surgery, Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
05/2016 Featured Alumni, Willamette University |
02/2017 Individual Travel Award, Gordon Research Seminar |
06/2017 Travel Funds Award, Geographic Management of Cancer Health Disparities Region 3 |
09/2019 2019 Outstanding Dissertation Award, UCSD Biomedical Sciences Doctoral Program |
11/2021 2021 Young Investigator Award, American Pancreatic Association |
05/2023 Rising Star Award, Midwest Tumor Microenvironment Meeting |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
07/2015 - 03/2017 Frontiers in Molecular Neuroscience |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
01/2009 - 05/2009 Selected student representative, Search committee for the hire of a tenure-track animal physiologist, Willamette University Department of Biology |
09/2009 - 12/2009 Selected student representative, Search committee for the hire of a tenure track microbiologist, Willamette University Department of Biology |
09/2012 - 05/2013 First-year student representative, Student Council, UCSD Biomedical Sciences Graduate Program |
09/2013 - 05/2014 Committee lead, Welcome Committee for Incoming Students, UCSD Biomedical Sciences Graduate Program |
09/2014 - 05/2015 Selected student representative, Admissions Committee, UCSD Biomedical Sciences Graduate Program |
04/2017 Selected student representative, Pharmacology Department Seminar Committee, UCSD |
12/2019 - 10/2022 Organizer of monthly Salk Featured Fellows lecture series, Society of Research Fellows, Salk Institute |
05/2021 - 10/2021 Lead for online virtual materials and interactive components, Salk Science at the Seaside Annual Symposium organization committee, Salk Institute |
07/2021 - 09/2021 Organizer of the community cleanup project, Society of Research Fellows, Salk Institute |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Targeting stem cell signals in pancreatic cancer, Stand Up to Cancer, Pancreatic Cancer Research Dream Team UK, London, England, 10/2016 |
National |
Liver damage enhances pancreatic cancer liver metastasis, American Pancreatic Association Annual Meeting, Miami, FL, 11/2021 |
Obesity and menopause synergize to reprogram mammary epithelium and enhance breast tumorigenesis, Mechanisms & Models of Cancer, Cold Spring Harbor Laboratory, NY, 07/2022 |
Tissue Injury Contributes to Cell State Instability and Tumor Progression, Epithelial Biology Center Lab Seminar Series, Vanderbilt University, Nashville TN, 04/21/2023 |
Regional |
RORgamma is a novel regulator of stem cell signals in pancreatic cancer, C3-PCRG Lecture Series, San Diego, CA, 08/2018 |
A multiscale map of the stem cell state in pancreatic cancer, Salk T32 Cancer Symposium, San Diego, CA, 12/2018 |
Oxaliplatin treatment induces a pre-metastatic liver niche by triggering secretion of Timp1 by liver endothelial cells, Midwest Tumor Microenvironment Meeting, Purdue University, Lafayette IN, 05/24/2023 |
Local |
Malignant progression of pancreatic adenocarcinoma is critically dependent on Musashi, UCSD Pharmacology Department Retreat, San Diego, CA, 05/2015 |
Unraveling heterogeneity of therapy resistance in pancreatic cancer, UCSD Biomedical Sciences Pharmacology Track Orientation, San Diego, CA, 09/2015 |
Delineation and targeting of pancreatic cancer stem cell networks, Cancer Genomics Cross Laboratory Meeting, San Diego, CA, 09/2017 |
Identification of pancreatic cancer stem cell dependencies using a genome-wide CRISPR screen, CRISPR Screening Workshop, San Diego, CA, 12/2017 |
Identification and targeting of pancreatic cancer stem cells, UCSD Pharmacological Sciences Department Retreat, San Diego, CA, 02/2018 |
Therapeutic targeting of stem cell signals blocks pancreatic cancer progression, Legacy Research Institute Seminar Series, Portland, OR, 09/2018 |
Chemotherapy-induced liver damage promotes pancreatic cancer liver metastasis, Salk Science at the Seaside, San Diego, CA, 10/2021 |
Liver damage enhances pancreatic cancer liver metastasis, C3-PCGR Lecture Series, La Jolla, CA, 04/2022 |
Chemotherapy-associated liver injury enhances pancreatic cancer liver metastasis, Pancreatic Cancer Scientific Retreat, Milwaukee, WI, 11/2022 |
Mammary epithelial cell states in injury and tumor progression, MCW Breast Cancer Disease Oriented Team, Milwaukee, WI, 01/2023 |
Mammary luminal cell plasticity and tumor-susceptibility is enhanced in obesity and menopause, MCW Breast Cancer Disease Oriented Team, Milwaukee, WI, 02/2023 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
04/01/2023 - 04/21/2023 Judge, MCW Cancer Center Trainee Symposium abstract selection committee |
EXTRAMURAL TEACHING: |
Graduate Student Education |
09/2016 - 12/2016 University of California San Diego, Lead Instructional Assistant, The Cell |
COMMUNITY SERVICE ACTIVITIES: |
03/2019 Fast Pitch speaker at Komen San Diego's Annual Metastatic Breast Cancer Conference |
03/2019 Science Advocate, Susan G. Komen San Diego More Than Pink Annual Fundraiser |
07/2019 Speaker, Salk Women & Science Fundraiser |
07/2019 Volunteer scientist, Project LEAD Institute, Breast Cancer Advocacy Training |
10/2019 Speaker, Salk Women & Science Fundraiser |
11/2019 Salk Scientist representative, Business and Youth Expo |
02/2020 Volunteer scientist, March of Dimes High School Science Day |
02/2021 Guest scientist, Where Cures Begin Salk Podcast, Season 3 Episode 21 |
02/2021 Volunteer speaker for science outreach program, Monarch High School for disadvantaged youth |
02/2021 Volunteer science panelist, March of Dimes High School Science Week |
04/2021 Speaker, Sky Foundation 13th Annual Women's Event |
07/2021 Volunteer scientist, Project LEAD Institute, Breast Cancer Advocacy Training |
11/2022 Speaker, Pancreatic Cancer Awareness Month MCW Patient Lecture Series |
11/2022 Guest scientist, The Word on Medicine podcast, Pancreatic Cancer Awareness Month episode |
02/2023 Guest scientist, The Voice of Pancreatic Cancer Podcast |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Lusardi TA, Lytle NK, Szybala C, Boison D. Caffeine prevents acute mortality after TBI in rats without increased morbidity. Exp Neurol. 2012 Mar;234(1):161-8. PMCID: PMC3294054 |
2. Duncan JE, Lytle NK, Zuniga A, Goldstein LS. The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PLoS One. 2013;8(6):e68324. PMCID: PMC3694009 |
3. Williams-Karnesky RL, Sandau US, Lusardi TA, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest. 2013 Aug;123(8):3552-63. PMCID: PMC3726154 |
4. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. PMCID: PMC4183333 |
5. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Cell Stem Cell. 2015 Aug 06;17(2):152-164. PMCID: PMC4664079 |
6. Shen HY, van Vliet EA, Bright KA, Hanthorn M, Lytle NK, Gorter J, Aronica E, Boison D. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65. PMCID: PMC4655139 |
7. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 Jun 16;534(7607):407-411. PMCID: PMC4998062 |
8. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14;30(5):792-805. PMCID: PMC5137811 |
9. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11;32(6):824-839.e8. PMCID: PMC5730340 |
10. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 Sep 10;34(3):466-482.e6. PMCID: PMC6152943 |
11. Lytle NK, Barber AG, Reya T. Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer. 2018 Nov;18(11):669-680. PMCID: PMC8388042 |
12. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell. 2019 Apr 18;177(3):572-586.e22. PMCID: PMC6711371 |
13. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 May;569(7754):131-135. PMCID: PMC6565370 |
14. Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020 Jan;3(1). PMCID: PMC6971368 |
15. Lusardi TA, Lytle NK, Gebril HM, Boison D. Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury. J Caffeine Adenosine Res. 2020 Mar 01;10(1):12-24. PMCID: PMC7071069 |
16. Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC Jr, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A. 2020 Jun 02;117(22):12121-12130. PMCID: PMC7275768 |
17. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D<sub>2</sub>. Gastroenterology. 2020 Nov;159(5):1866-1881.e8. PMCID: PMC7680354 |
18. Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. Gastroenterology. 2022 Feb;162(2):604-620.e20. PMCID: PMC8792222 |
19. Ma Z, Lytle NK, Ramos C, Naeem RF, Wahl GM. Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo. Methods Mol Biol. 2022;2471:49-82. PMCID: PMC9663269 |
20. Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE. Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. Gastro Hep Adv. 2022;1(4):682-697. PMCID: PMC9583893 |
21. Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, Koechlein CS, Lytle N, Kwon HY, Anower-E-Khuda F, Sun H, Blevins A, Weeks J, Kritzik M, Karlseder J, Ginsberg MH, Park PW, Esko JD, Reya T. A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nat Commun. 2020 Nov 26;11(1):5998. PMCID: PMC7691523 |
22. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014;9(5):e96432. PMCID: PMC4008632 |
23. Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T. Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nat Commun. 2023 Jan 18;14(1):292. PMCID: PMC9849267 |
24. Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T. Single-cell mapping identifies MSI<sup>+</sup> cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. 2023 Nov 13;41(11):1989-2005.e9. PMCID: PMC10836835 |
25. Vallmajo-Martin Q, Ma Z, Srinivasan S, Murali D, Dravis C, Mukund K, Subramaniam S, Wahl GM, Lytle NK. The molecular chronology of mammary epithelial cell fate switching. bioRxiv. 2024 Nov 04. PMCID: PMC11482796 |
