CURRICULUM VITAE
Pui Ying Lam PhD
Pui Ying Lam PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Department of Cell Biology, Neurobiology and Anatomy
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 2008 Jun 04;27(11):1537-48. PMCID: PMC2426729 |
2. Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam PY, Majumdar A, Zhao J, Poon KL, Kondrychyn I, Korzh V, Drummond IA. Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 2009 Jan 06;7(1):e9. PMCID: PMC2613420 |
3. Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL. Inhibition of stored Ca2+ release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. Dev Growth Differ. 2009 May;51(4):429-42. |
4. Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA. The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech. 2010;3(5-6):354-65. PMCID: PMC2860853 |
5. Lam PY, Yoo SK, Green JM, Huttenlocher A. The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. J Cell Sci. 2012 Nov 01;125(Pt 21):4973-8. PMCID: PMC3533387 |
6. Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A. The role of microtubules in neutrophil polarity and migration in live zebrafish. J Cell Sci. 2012 Dec 01;125(Pt 23):5702-10. PMCID: PMC3575705 |
7. Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA. odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Dev Dyn. 2013 Nov;242(11):1284-92. PMCID: PMC4041527 |
8. Lam PY, Harvie EA, Huttenlocher A. Heat shock modulates neutrophil motility in zebrafish. PLoS One. 2013;8(12):e84436. PMCID: PMC3868611 |
9. Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. 2014 Dec 08;207(5):589-98. PMCID: PMC4259815 |
10. Lam PY, Mangos S, Green JM, Reiser J, Huttenlocher A. In vivo imaging and characterization of actin microridges. PLoS One. 2015;10(1):e0115639. PMCID: PMC4309568 |
11. Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD. Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cell Microbiol. 2016 Apr;18(4):591-604. PMCID: PMC5027955 |
12. Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Sci Rep. 2017 Sep 19;7(1):11839. PMCID: PMC5605526 |
13. Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808. PMCID: PMC5702045 |
14. Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT. Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nat Chem Biol. 2018 Sep;14(9):844-852. PMCID: PMC6800240 |
15. Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 Apr 22;49(2):189-205.e6. PMCID: PMC6708378 |
16. Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Cornella Taracido I, Johns DG, Beerens M, MacRae CA, Caldwell JP, Sorota S, Asnani A, Peterson RT. Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model. Chembiochem. 2020 Jul 01;21(13):1905-1910. PMCID: PMC7500981 |
17. Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW. Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. J Nat Prod. 2020 Apr 24;83(4):1249-1257. PMCID: PMC10172148 |
18. Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT. TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel. J Am Chem Soc. 2020 Oct 14;142(41):17457-17468. PMCID: PMC8011302 |
19. Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Sci Rep. 2020 Sep 24;10(1):15716. PMCID: PMC7518243 |
20. Lam PY. Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy. Dis Model Mech. 2022 Dec 01;15(12). PMCID: PMC9844135 |
21. Sampieri A, Padilla-Flores T, Thawani AR, Lam PY, Fuchter MJ, Peterson R, Vaca L. The conducting state of TRPA1 modulates channel lateral mobility Cell Calcium. December 2023;116. |
Books, Chapters, and Reviews |
1. Lam PY, Huttenlocher A. Interstitial leukocyte migration in vivo. Curr Opin Cell Biol. 2013 Oct;25(5):650-8. PMCID: PMC3782709 |
2. Lam PY, Fischer RS, Shin WD, Waterman CM, Huttenlocher A. Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods Mol Biol. 2014;1124:219-33. PMCID: PMC4087032 |
3. Fischer RS, Lam PY, Huttenlocher A, Waterman CM. Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Dev Biol. 2019 Jul 01;451(1):86-95. PMCID: PMC7082808 |
4. Lam PY, Peterson RT. Developing zebrafish disease models for in vivo small molecule screens. Curr Opin Chem Biol. 2019 Jun;50:37-44. PMCID: PMC6800242 |
