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CURRICULUM VITAE

Sally S. Twining PhD
Assistant Dean, Professor
Department of Biochemistry

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/1965 - 08/1969 B.S. in Chemistry and Music, Bowling Green State University, Bowling Green, OH
09/1969 - 06/1971 M.A. in Chemistry, Bowling Green State University, Bowling Green, OH
09/1973 - 12/1976 Ph.D. in Physiological Chemistry, Ohio State University, Columbus, OH

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
12/1976 - 12/1979 Mayo Fellow in Immunology, Mayo Clinic Foundation, Rochester, MN
05/1979 - 08/1980 VFW Auxiliary Fellow in Biochemistry, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
09/1971 - 06/1973 Instructor in Chemistry, Bowling Green State University, Bowling Green, OH
09/1980 - 06/1983 Instructor in Biochemistry, Medical College of Wisconsin, Milwaukee, WI
07/1983 - 06/1989 Assistant Professor in Biochemistry, Medical College of Wisconsin, Milwaukee, WI
07/1985 - 06/1989 Assistant Professor in Ophthalmology (Secondary), Medical College of Wisconsin, Milwaukee, WI
07/1989 - 2004 Associate Professor in Biochemistry, Medical College of Wisconsin, Milwaukee, WI
07/1989 - 2004 Associate Professor in Ophthalmology (Secondary), Medical College of Wisconsin, Milwaukee, WI
09/1998 - 03/1999 Visiting Scientist in Biochemistry, University of Wisconsin, Madison, WI
09/2004 - Present Professor in Ophthalmology (secondary), Medical College of Wisconsin, Milwaukee, WI
09/2004 - Present Professor in Biochemistry with tenure, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
01/1990 - Present Director of the Glucose Laboratory in Medical Biochemistry, Medical College of Wisconsin, Milwaukee, WI
09/1991 - Present Block Leader, Medical Biochemistry, Medical College of Wisconsin, Milwaukee, WI
01/1993 - 1999 Course Director, Contemporary Biochemistry (Graduate), Medical College of Wisconsin, Milwaukee, WI
01/2008 - 05/2008 Course Director, Introduction to Biostatistics (Graduate), Medical College of Wisconsin, Milwaukee, WI
09/2008 - Present Course Director, Boundaries of Science and Medical Practice (Graduate), Medical College of Wisconsin, Milwaukee, WI
08/2009 - Present Director, PhD in Basic and Translational Sciences (Graduate), Medical College of Wisconsin, Milwaukee, WI
09/2010 - Present Co-Module Director, GI-Nutrition, Pilot Innovation Curriculum, Medical College of Wisconsin, Milwaukee, WI
03/2011 - Present Executive Integration Director, Pilot Innovation Curriculum, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
05/1983 Travel Fellowship, Association for Research in Vision and Ophthalmology
08/1985 Travel Fellowship, American Society of Biological Chemists 13th International Congress of Biochemistry, Amsterdam
08/1991 Travel Fellowship, American Society of Biological Chemists 15th International Congress of Biochemistry, Israel
05/1992 Alumna of the Year, Bowling Green State University, Chemistry Department
06/1996 Innovative Educational Project Award, Department of Family and Community Medicine, Medical College Of Wisconsin
09/2001 Twenty-Year Faculty Award, Medical College of Wisconsin
09/2006 Twenty-five-Year Faculty Award, Medical College of Wisconsin
2007 - 2008 Outstanding Medical Student Teacher, Medical College of Wisconsin
05/2008 Distinguished Service Award, Medical College of Wisconsin
09/2008 Graduate Mentor of the Year, Medical College of Wisconsin
2008 - 2009 Outstanding Medical Student Teacher, Medical College of Wisconsin
2009 - 2010 Outstanding Medical Student Teacher, Medical College of Wisconsin
2010 Fellow, The Association for Research in Vision and Ophthalmology

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1969 - Present American Chemical Society
1973 - Present American Association for the Advancement of Science
1974 - Present Sigma Xi
1982 - Present Association for Research in Vision and Ophthalmology
1984 - Present American Society for Biochemistry and Molecular Biology
2000 - Present American Society for Cell Biology

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
1998 - 2008 Investigative Ophthalmology and Visual Sciences for Proteases in the Eye and Biochemistry of the Cornea
Journal Review
1982 - Present Alcoholism
1982 - Present Molecular Vision
1982 - Present British Journal of Ophthalmology
1982 - Present Experimental Eye Research
1982 - Present Protein Expression and Purification
1982 - Present Alcohol
1982 - Present Biological Bulletin
1982 - Present Journal of Biological Chemistry
1982 - Present Archives of Ophthalmology
1982 - Present FASEB Journal
1982 - Present Biochemical Journal
1982 - Present Current Eye Research
1982 - Present Investigative Ophthalmology and Visual Sciences
1982 - Present Biochemistry
1982 - Present Biochimica Biophysica Acta
1982 - Present Analytical Biochemistry
1982 - Present BioTechniques

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1985 Ad Hoc Member, Physiological Chemistry Study Section, NIH
1988 Reviewer, Veterans Administration Merit Review
1989 Ad Hoc Reviewer, USDA
1991 - 1993 Ad Hoc Member, Visual Sciences C Study Section, NIH
1993 Ad Hoc Reviewer, USDA
1994 - 1998 Member, Visual Sciences A Study Section, NIH
1997 Member, Peer Review Panel on Photorefractive Keratectomy (PRK) Research, American Institute of Biological Sciences
1998 Ad Hoc Member, Scientific Board of Councilors, National Eye Institute, NIH
2001 Member, Visual Sciences Special Study Section, NIH
2003 - 2006 Member, Program Committee, Association for Research in Vision and Ophthalmology
2005 - 2006 Co-Chair, Cornea Program Committee, Association for Research in Vision and Ophthalmology
2005 Ad Hoc Member, Fogarty Grants, NIH Study Section
2006 Member, Chemical Counterterrism, Special NIH Study Section
2007 Chair, Anterior Eye Disease Special Study Section, NIH
2007 - Present Chair, External Advisory Board, UMDNJ/Rutgers University CounterACT Research Center of Excellence, AR055073

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator and Animal Surgery Module Director; Co-director of Biochemistry Module
PI:
Janice Burke, Ph.D.
Dates:
2007 - 2012
Direct Funds:
$2,000,000
 
Title:
Proteases in the Cornea
Source:
NIH: RO1-EY12731
Role:
Principal Investigator
PI:
Sally Twining, PhD
Dates:
2007 - 2012
Direct Funds:
$1,250,000
 
Title:
Vision Training Grant
Source:
NIH: T32-EY014537
Role:
Mentor
PI:
Joseph Besharse, Ph.D.
Dates:
2008 - 2013
Direct Funds:
$893,322
 
Title:
Effect of Maspin on Corneal Heme- and Lymph-angiogenesis
Source:
NIH: RO1-EY12731
Role:
Principal Investigator
PI:
Sally Twining, PhD
Dates:
2011 - 2015
Direct Funds:
$999,975
 
Prior
Peer Review
Title:
Isolation and Purification of Low Molecular Weight Protease Inhibitors from Malignant Breast Tissue
Source:
Veterans` of Foreign Wars Auxiliary
Role:
Post Doctoral Fellow
PI:
Sally Twining, Ph.D. (Sponsor: David Glick, Ph.D.)
Dates:
1979 - 1980
Direct Funds:
$12,000
 
Title:
Role of Immunological and Nonimmunological Factors in Eliciting Polymorphonuclear Neutrophil Directed Migration in the Cornea
Source:
National Society for the Prevention of Blindness
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1983 - 1984
Direct Funds:
$9,310
 
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator
PI:
Henry F. Edelhauser and Janice Burke, Ph.D.
Dates:
1983 - 1987
Direct Funds:
$431,393
 
Title:
Functions of Invading Cells After Vitreal Injury
Source:
NIH: ROl EY04800
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1983 - 1985
Direct Funds:
$191,220
 
Title:
The Role of Proteases and Antiproteases in Corneal Degradation
Source:
NIH: R23 EY04597
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1983 - 1986
Direct Funds:
$107,500
 
Title:
Vitreal Mitogens and Retinal Glial Cells in Proliferative Vitreal Retinopathy
Source:
NIH: ROl EY04799
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1984 - 1987
Direct Funds:
$231,150
 
Title:
Vision Research Training Grant
Source:
NIH: ROl EY04799
Role:
Co-Investigator
PI:
William J. O'Brien, Ph.D.
Dates:
1985 - 1990
Direct Funds:
$499,416
 
Title:
Role of Proteases in Corneal Degradation
Source:
NIH: ROl EY06663
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1986 - 1989
Direct Funds:
$221,726
 
Title:
Visual Material Upgrade
Source:
Learning Resources
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1986 - 1988
Direct Funds:
$3,000
 
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1987 - 1992
Direct Funds:
$604,931
 
Title:
Is the First Line of Defense Against Infections Impaired Under Vitamin A Deficiency?
Source:
Thrasher Foundation 2800-3
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1987 - 1988
Direct Funds:
$39,361
 
Title:
Cell Biology of Vitreoretinal Proliferative Disease
Source:
NIH: ROl EY04799
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1987 - 1992
Direct Funds:
$496,331
 
Title:
Macular Degeneration: Macular vs Extramacular Retinal Pigment Epithelial Cells
Source:
NIH: ROl EY06664
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1987 - 1990
Direct Funds:
$190,670
 
Title:
Role of Proteases in Corneal Degradation
Source:
NIH: R01-EY06663
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1989 - 1994
Direct Funds:
$487,543
 
Title:
Effect of Vitamin A Deficiency on Leukocyte Function
Source:
NIH: RO1-EY08388
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1990 - 1996
Direct Funds:
$416,601
 
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
1992 - 1997
Direct Funds:
$850,000
 
Title:
Role of Proteases in Corneal Degradation
Source:
NIH: RO1-EY06663
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1994 - 1998
Direct Funds:
$345,014
 
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator and Module Director
PI:
Janice Burke, Ph.D.
Dates:
1997 - 2002
Direct Funds:
$1,175,000
 
Title:
Control of corneal protein synthesis by retinol/retinaldehyde by a retinoic acid independent mechanism
Source:
Research Affairs Committee
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1998 - 1999
Direct Funds:
$12,500
 
Title:
Mechanisms of interaction of the tumor suppressor maspin with the cell surface of mammary carcinoma cells
Source:
Cancer Center
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1999 - 2000
Direct Funds:
$15,000
 
Title:
Proteases and Corneal Ulceration
Source:
NIH: RO1-EY12731
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
1999 - 2004
Direct Funds:
$524,559
 
Title:
Core Grant for Vision Research
Source:
NIH: P30 EY0l93l
Role:
Co-Investigator and Animal Surgery Module Director; Co-director of Biochemistry Module
PI:
Janice Burke, Ph.D.
Dates:
2002 - 2007
Direct Funds:
$2,000,000
 
Title:
Maspin in the Cornea
Source:
NIH: RO1-EY14168
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
2002 - 2007
Direct Funds:
$800,000
 
Title:
Determinants of Phenotype in Retinal Pigment Epithelium
Source:
NIH: RO1-EY015284
Role:
Co-Investigator
PI:
Janice Burke, Ph.D.
Dates:
2003 - 2007
Direct Funds:
$225,000
 
Title:
Vision Training Grant
Source:
NIH: T32-EY014537
Role:
Mentor
PI:
Joseph Besharse, Ph.D.
Dates:
2003 - 2008
Direct Funds:
$893,322
 
Title:
Serpin Mechanism of Inhibition of Invasion and Metastasis in Mammary Carcinoma
Source:
State of Wisconsin Breast Cancer Grant
Role:
Principal Investigator
PI:
Sally Twining, PhD
Dates:
2006 - 2007
Direct Funds:
$50,000
 
Title:
Planning and Implementation of the Community of Scientific Innovators
Source:
Advancing a Healthier Wisconsin
Role:
Principal Investigator
PI:
Sally Twining, Ph.D.
Dates:
2006 - 2009
Direct Funds:
$135,000
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Vitamin A and Immunity, Fourteenth Symposium on Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI, 09/1994
 
National
Human Corneal Serine Proteinases, National Meeting of the Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL, 05/1997
Pseudomonas aeruginosa Proteases, National Meeting of the Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL, 05/1998
Effects of maspin on corneal stromal cell gene expression: Increased protein levels of SPARC and PAI-1, National Meeting of the Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL, 04/2004
Role of the reactive site loop in the function of maspin, Steinbock Symposium, University of Wisconsin, 05/2004
 
International
Proteases and Proteoglycans in Vitamin A Deficiency, World Congress on the Cornea, III, Boston, 1987
Corneal ulceration: Disruption of the Proteinase-Inhibitor Balance, XII International Congress on Eye Research, Yokohama, Japan, 09/1996
Corneal Ulceration and the Proteinase-Inhibitor Balance, International Contact Lens Society, Florence, Italy, 08/1997
Proteinases in Corneal Ulceration, International Congress on Eye Research, Paris, France, 08/1999
Structure-function of Maspin, SERPINS Meeting, Cairns, Australia, 06/2005
Corneal Proteinases, ICER Meeting, Buenos Aires, 10/2006
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Proteases in Corneal Ulceration Due to Vitamin A Deficiency with Histological Correlations, University of Wisconsin Parkside, Department of Life Sciences, Kenosha, WI, 10/1984
The Influence of the Immune System in Pseudomonas Keratitis in Rats, Carroll College, Department of Biology, Waukesha, WI, 10/1986
Opportunities for Research in Medicine, University of Wisconsin Milwaukee, Milwaukee, WI, 11/1987
Effect of Vitamin A Deficiency on Polymorphonuclear Leukocyte Function, Beloit College, Department of Biology, Beloit, WI, 02/1988
Perspectives on Research, Target MD Seminar, University of Wisconsin - Milwaukee, Milwaukee, WI, 12/1988
Research in Medicine, Target MD Seminar, University of Wisconsin - Milwaukee, Milwaukee, WI, 10/1989
Effect of Vitamin A Deficiency on Polymorphonuclear Leukocyte Function, U. Wisconsin-Madison, Department of Nutrition, Madison, WI, 11/1992
 
Regional
Proteases in Vitamin A Deficient Corneas, College of St. Catherine, Department of Chemistry, St. Paul, MN, 11/1983
Proteases and Protease Inhibitors in Normal Corneas, Hope College, Department of Chemistry, Holland, MI, 11/1985
Role of Polymorphonuclear Leukocytes in Pseudomonas aeruginosa Infections, Wayne State University, Department of Anatomy and Cell Biology, Detroit, MI, 03/1989
Effects of Polymorphonuclear Leukocytes on the Cornea during Inflammation, Northern Illinois University, Department of Biology, DeKalb, IL, 05/1990
Control of Proteolysis in the Cornea, University of Illinois Medical School, Dept. Ophthalmology, Chicago, IL, 04/1995
Pseudomonas Proteinases: A New Elastase Variant, Wayne State University, Dept. Microbiology, Detroit, MI, 12/1997
Proteinases and Inhibitors in the Cornea, Northern Illinois University, Center for Biochemical and Biophysical Studies, DeKalb, IL, 03/2002
Corneal Wound Healing, Hillsdale College, Department of Chemistry, Hillsdale, MI, 09/2003
 
National
Mechanism of Pepsinogen Activation, Bowling Green State University, Department of Chemistry, Bowling Green, OH, 03/1984
Role of Women in Chemistry, Bowling Green State University, American Chemical Society Student Affiliate, Bowling Green, OH, 03/1984
Proteases and Protease Inhibitors in the Cornea, Boston Eye Research Institute, Boston, MA, 03/1987
Role of Proteinase Inhibitors in the Cornea, National Institutes of Health, Eye Institute, Bethesda, MD, 10/1991
Isolation and Properties of Corneal Proteoglycan-Proteinase Complexes, Bowling Green State University, Department of Chemistry, Bowling Green, OH, 01/1992
Role of Proteinases in Pseudomonas Keratitis, Vistacon, Jacksonville, FL, 03/1993
Corneal 1-Proteinase Inhibitor: Specific Control by Retinoids, National Institutes of Health, Eye Institute, Bethesda, MD, 10/1995
Plasminogen in the Cornea, Temple University, Department of Biology, Philadelphia, PA, 04/1998
Chameleon Proteins: Mechanism of Conversion of Plasminogen to Angiostatin, Bowling Green State University, Department of Chemistry, Bowling Green, OH, 02/2001
Molecular Mechanisms By Which The Cornea Prevents Tumor Formation, Roswell Park Cancer Institute, Buffalo, NY, 04/2001
Conversion of Serpins: Making Ovalbumin into a Maspin-like Molecule, Jackson State University, Jackson, MS, 02/2002
Conversion of Serpins: Making Ovalbumin into a Maspin-like Molecule, National Institutes of Health, National Eye Institute, Bethesda, MD, 02/2002
 

COMMITTEE SERVICE:
Medical College of Wisconsin
1984 - 1986 Admission Committee (Elected), Subcommittee for Minority Admissions, Medical College of Wisconsin
1985 - 1987 Member, Target M.D., Committee of the University of Wisconsin Milwaukee, Medical College of Wisconsin
1986 - 1987 Chair, Admission Committee (Elected), Admission Subcommittee on Recruitment, Medical College of Wisconsin
1986 - 1987 Student Affairs Committee (Appointed), Medical College of Wisconsin
1988 - 2004 Library Committee, Medical College of Wisconsin
1989 Dean's Committee for the Internal Review, Physiology Department, Medical College of Wisconsin
1990 - 1993 Marquette Scholars Committee, Medical College of Wisconsin, Faculty Representative, Admission Committee (Elected), Medical College of Wisconsin
1990 - 1993 Animal Care Committee (Elected), Medical College of Wisconsin
1991 - 1993 Dissertation Prize Committee, Medical College of Wisconsin
1991 - 2006 Animal Surgery Core Director, NEI Core Grant for Vision Research Committee, Medical College of Wisconsin
1991 - 1995 Graduate Studies Committee, Medical College of Wisconsin
1991 - 1993 Graduate Recruitment Director, Graduate Committee, Medical College of Wisconsin
1993 - 1996 Academic Standing Committee (Elected), Medical College of Wisconsin
1993 - 1995 Faculty Welfare Committee (Elected), Medical College of Wisconsin
1993 - 1995 Armand J. Quick Award Committee, Medical College of Wisconsin
1993 - 1996 1993-1996 Integrated Academic Information Management Systems Planning Committee, Medical College of Wisconsin
1993 - 1995 Chair, Nominating Committee, Medical College of Wisconsin
1993 - 1995 Graduate Program Director, Graduate Committee, Medical College of Wisconsin
1993 - 1998 Representative, Bloodborne Pathogen, Medical College of Wisconsin
1994 Chair of the Graduate School Review, Liaison Committee for Medical Education Review Committee, Medical College of Wisconsin
1996 - 1997 Search Committee for Chair of Ophthalmology, Medical College of Wisconsin
1996 Search Committee for Associate Dean for Curricular Affairs, Medical College of Wisconsin
1998 - 2001 Chair, Armand J. Quick Award Committee, Medical College of Wisconsin
1999 - 2004 Computer Committee, Medical College Of Wisconsin
1999 - 2002 Admission Committee (Appointed), Medical College of Wisconsin
2000 - 2002 Admission Committee (Appointed), Executive Committee of the Admission Committee, Medical College of Wisconsin
2000 - 2002 Instructional Computing Committee, Medical College of Wisconsin
2000 - 2005 Chair, Student Welfare Committee, Medical College of Wisconsin
2000 - Present Ph.D. Qualifying Exam Committees, Medical College of Wisconsin
2000 - 2002 Admission Committee (Appointed), Committee on Diversity, Medical College of Wisconsin
2001 - 2003 Graduate Committee, Medical College Of Wisconsin
2001 - Present Mentoring Committee, Medical College of Wisconsin
2001 - Present Graduate Studies Committee, Medical College of Wisconsin
2001 Focus Group on the Name, Identity and Image of the Medical College of Wisconsin, Medical College of Wisconsin
2002 - 2003 LCME Accreditation Task Force, Medical College of Wisconsin
2002 - 2005 Curriculum and Evaluation Committee (Elected), Executive Committee, Medical College of Wisconsin
2002 - 2007 Women’s Faculty Council (Appointed), Medical College of Wisconsin
2002 - 2003 LCME Accreditation Review Committee on Students, Medical College of Wisconsin
2002 - 2005 Chair, Curriculum and Evaluation Committee (Elected), M1/M2 Subcommittee, Medical College of Wisconsin
2003 Focus Group for the Establishment of Guidelines for the MCW Educational IRB, Medical College of Wisconsin
2003 Search Committee for Associate Dean for Curricular Affairs, Medical College of Wisconsin
2003 - 2006 Graduate Program Director, Graduate Committee, Medical College Of Wisconsin
2003 - 2004 Chair, Women’s Faculty Council (Appointed), Program Committee, Medical College of Wisconsin
2003 Focus Group for the Revision of Medical Information Management Course, Medical College of Wisconsin
2004 - 2005 Chair Elect, Women’s Faculty Council (Appointed), Medical College of Wisconsin
2004 Focus Group for Establishment of the Global Learning Objectives for M1-M2 years, Medical College of Wisconsin
2004 - 2006 M1 Advisor, Medical School Student Assembly, Medical College of Wisconsin
2005 - 2006 Women’s Faculty Council Representative, Faculty Council, Medical College of Wisconsin
2005 - 2006 Chair, Women’s Faculty Council (Appointed), Medical College of Wisconsin
2006 - 2010 Executive Committee, Medical College of Wisconsin
2006 - 2010 Armand J. Quick Award Committee, Medical College Of Wisconsin
2006 - 2012 Faculty Council and Governance Committee (Elected), Medical College of Wisconsin
2006 - Present Women in Science Advisory Committee, Medical College of Wisconsin
2006 - 2010 Curriculum Committee, Medical College of Wisconsin
2006 - 2007 Chair Emeritus, Women’s Faculty Council (Appointed), Medical College of Wisconsin
2006 - 2007 Vice President, Faculty Council and Governance Committee (Elected), Medical College of Wisconsin
2006 - Present Biochemistry Co-Core Director, NEI Core Grant for Vision Research Committee, Medical College of Wisconsin
2007 Co-Leader for Education and Training, CTSA Key Function Group, Medical College of Wisconsin
2007 Chair, Women’s Faculty Council (Appointed), Woman in Science Award Selection Committee, Medical College of Wisconsin
2007 - 2009 Faculty Council Representative, Executive Committee of the Faculty, Medical College of Wisconsin
2007 - 2008 Chair, Ad Hoc Certificate Committee, Medical College of Wisconsin
2007 - 2008 Search Committee for Cancer Faculty, Medical College of Wisconsin
2007 - Present Co-Leader for Education and Training, CTSA Key Function Group, Medical College Of Wisconsin
2007 - 2008 Sr Vice President, Faculty Council and Governance Committee (Elected), Medical College of Wisconsin
2008 - 2009 President, Faculty Council and Governance Committee (Elected), Medical College of Wisconsin
2008 - Present Faculty and Staff Gift Drive Committee (Appointed), Medical College of Wisconsin
2009 - Present Ad Hoc Member Representing the Faculty Governance Committee (Appointed), Curriculum and Evaluation Committee, Medical College of Wisconsin
2009 - 2012 Past President, Faculty Council and Governance Committee (Elected), Medical College of Wisconsin
2009 - 2010 Graduate School Dean Search Committee, Medical College of Wisconsin
2009 - 2011 Dean’s Educational Innovation Advisory Committee, Medical College of Wisconsin
2009 - 2010 Search Committee for the President of MCW, Medical College of Wisconsin
2009 - 2011 Researcher Search Committee, Medical College of Wisconsin
2010 LCME Accreditation Task Force, Medical College of Wisconsin
2010 hair, LCME Accreditation Review Committee on Faculty, Medical College of Wisconsin
2010 - Present MS in Clinical and Translational Science Advisory Committee, Medical College Of Wisconsin
2011 Search Committee for the Senior Vice President for Finance and Administration of MCW, Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Community/Lay Public
2003 Mini Med School-Biochemical Basis of Phenylketonuria
 
Medical Student Education
1983 - Present Medical Biochemistry
1983 - 1987 Summer Bridging Program: Lecturer
1985 - 1988 Introduction to Clinical Medicine
2002 - Present Basic Science of Pediatrics Problem Solving – M4 Selective
2003 Grand Rounds-Intrauterine Growth Restriction
2011 Pilot Innovation Curriculum
 
Resident and Fellow Education
1987 - Present Ophthalmology Resident Lecture Series
 
Graduate Student Education
1984 - 1987 Seminar in Biochemistry
1985 - 1999 Protein Chemistry
1988 - 2000 Enzyme Chemistry
1990 - Present Physical Properties of Macromolecules-Biophysical Techniques in Biochemistry
1990 - 2000 Lipids, Carbohydrates and Membranes
1993 - 2005 Contemporary Topics in Biochemistry, Course Director (Every 3 yrs)
1999 - Present Biochemistry of the Cell
2003 - Present Protein Chemistry
2006 - 2008 Advanced Cell Signaling, Lecture on Protease Activated Receptors
2007 - Present Enzyme Kinetics
2008 Introduction to Biostatistics, Lectures on Applications of Biostatistics
2008 - Present Boundaries of Science and Medical Practice
2009 - Present Introduction to Clinical and Translational Sciences
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Jeff Jahnke, Medical College of Wisconsin, 1988
Jerry Loushin, Medical College of Wisconsin, 1989
Jerry Loushin, Medical College of Wisconsin, 1990
Simon Wright, Medical College of Wisconsin, 1994
Jerry Loushin, Medical College of Wisconsin, 1994
Vannah Nguyen, Medical College of Wisconsin, 1995
 
Graduate Students
PhD Committees
Joyce Tucker, Medical College of Wisconsin, 1982 - 1985 Serine Proteases of Aspergillus fumigatus
Tracy Kangas, Medical College of Wisconsin, 1985 - 1988 Effect of Edema on Corneal Proteoglycans
Kevin Langford, Medical College of Wisconsin, 1989 - 1995 Isolation and Characterization of the High Molecular Weight
Goran Boskovic, Medical College of Wisconsin, 1991 - 1996 Control of Synthesis of 1-Proteinase Inhibitor in the Human Cornea
Monica Olague-Alcala, Medical College of Wisconsin, 1995 - 2000 Characterization of the Structural Alterations Caused by a Disease-Associated Mutation (G627V) in the BP180 Protein (Type XVII Collagen)
Chatri Ngamkitdaichakul, Medical College of Wisconsin, 1997 - 2002 Regulation of Corneal Cells by Maspin
Guangjie Sun, Medical College of Wisconsin, 2001 - 2005 Understanding the Molecular Basis Underlying Carbohydrate Recognition by the CD-MPR
Malathi Narayan, Medical College of Wisconsin, 2005 - Present Phosphorylation of Maspin Synthesized by the Corneal Epithelium
Mark White, Medical College of Wisconsin, 2006 - 2010 Role of PepD in Tuberculosis
Erin Hassemer, Medical College of Wisconsin, 2006 - 2010 Anatomy and Neurosciences, Characterization of the woe mutation in ADAM 17
Kate Merath, Medical College of Wisconsin, 2007 - Present Ocular mutation in SHEFB-P
Mariam Hartley, Medical College of Wisconsin, 2007 - 2010 Roles of Metals and Metal Ligands in the Active Site of Vibrio proteolyticus aminopeptidase
Hong Guan, Medical College of Wisconsin, 2007 - 2009 Palmitoyl Acyl Transferases in Breast Cancer
Kay Ishizuka, Medical College of Wisconsin, 2007 - 2010 Spatial regulation of Ras protein and DHHC palmitoyltransferases in Sacharomyces cerevisiae
Alicia, Castonguay, Medical College of Wisconsin, 2008 - 2011 Function of Retinoid Binding on CD-MPR
Susan Salti, Medical College of Wisconsin, 2008 - Present Role of Granzyme B in T-Helper Cell Function
Emily Andreae, Medical College of Wisconsin, 2008 - Present Role of Thrombin in the Cornea
Bethany Volkman, Medical College of Wisconsin, 2008 - Present PITX in Lens Development
Luis Paniagua, Medical College of Wisconsin, 2009 - Present Role of RAP-1 in Platelets
Elizabeth Ntantie, Medical College of Wisconsin, 2009 - Present Phosphorylation of SmgGDS
LiLi Du, Medical College of Wisconsin, 2010 - Present Characterization of allosteric enhancers for the A3 adenosine receptor
Maxime Heroux, Medical College of Wisconsin, 2011 - Present Proteomics of Proteus Syndrome
MS Committees
Renee Madden, Medical College of Wisconsin, 1984 - 1987 Studies on the Interaction of Plasminogen Activator Inhibitor Type One with Thrombin: Possible Regulatory Mechanism of Fibrinolysis
Karen Tiffany, Medical College of Wisconsin, 1996 - 1999 Structure of Isovaleryl Acyl Dehydrogenase
Mark Nickolas, Medical College of Wisconsin, 1996 - 1998 Gene Structure of Corneal Maspin
Kelly Soules, Medical College of Wisconsin, 2004 - 2005 Characterization of Ocular Mutants in Zebrafish
Adam Harder, Medical College of Wisconsin, 2004 - 2005 Structure Function of BRAK
PhD Students Advised
Goran Boskovic, Medical College of Wisconsin, 1991 - 1996 Control of Synthesis of 1-Proteinase Inhibitor in the Human Cornea
Chatri Ngamikitdaichakul, Medical College of Wisconsin, 1997 - 2002 Regulation of Corneal Cells by Maspin
Malathi Narayan, Medical College of Wisconsin, 2005 - 2010 Mechanism of Maspin Function
Emily Andreae, Medical College of Wisconsin, 2008 - Present Function of Thrombin in the Cornea
MS Students Advised
Mark Nickolas, Medical College of Wisconsin, 1996 - 1998 Gene Structure of Corneal Maspin
 
Postdoctoral Students
Susan Kirshner, DVM, Medical College of Wisconsin, 1989 - 1990
Xiaoye Zhou, MD, Medical College of Wisconsin, 1991 - 1996
Monica Olague-Marchan, PhD, Medical College of Wisconsin, 2000 - 2002
 
Clinical/Research Fellows
Blythe Janowiak, Medical College of Wisconsin, 2001 primary mentor
Kasia Broniowska, Medical College of Wisconsin, 2003
Brajesh Kumar, Medical College of Wisconsin, 2004 primary mentor
Robert Walchak, Medical College of Wisconsin, 2004
Malathi Narayan, Medical College of Wisconsin, 2005
Wei Gauk, Medical College of Wisconsin, 2005
Kate Merath, Medical College of Wisconsin, 2006 primary mentor
Susan Salti, Medical College of Wisconsin, 2007 primary mentor
Sreemanti Basu, Medical College of Wisconsin, 2007
Kathrine Schmalzer, Medical College of Wisconsin, 2007
Jackie Porath, Medical College of Wisconsin, 2007
Luis Paniagua, Medical College of Wisconsin, 2007 primary mentor
Rebecca Bark, Medical College of Wisconsin, 2007 primary mentor
Ben Tourdot, Medical College of Wisconsin, 2008
Kim Agle, Medical College of Wisconsin, 2008
Emily Andreae, Medical College of Wisconsin, 2008 primary mentor
Nathan Schuld, Medical College of Wisconsin, 2010
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Brent Gilmore, Marquette High School, 1991 - 1992
Anna Marie Vu, Glendale High School, 2000
Brown Dear High School, 2007 - 2008 Students Modeling a Research Topic (Smart) Team (MSOE)
Lincoln High School, Manitowoc, 2008 - 2009 Students Modeling a Research Topic (Smart) Team (MSOE)
Antonica Amour, Pulaski High School, 2008
Messmer High School, Milwaukee, 2009 - 2010 Students Modeling a Research Topic (Smart) Team (MSOE)
Rupinder Grewal, Cudahy High School, 2010
St. Joan Antidia, 2010 - 2011 Students Modeling a Research Topic (Smart) Team (MSOE)
 
Undergraduate Students
Kevin Foley, Beloit College, 1984
Stephen Everse, Beloit College, 1987
Lisa Mahnke, Ripon College, 1991
Andrew Weber, University of Wisconsin, Stevens Point, 1994
Priscilla Moore, University of Wisconsin-Green Bay, 1999
Chris Miller, University of Dallas, 2000
Hieu Luu, Marquette University, 2001
Tyna MacGill, Carroll College, 2003 - 2004
 
Graduate Students
PhD Committees
Vincent Braganza, S.J., Department of Biochemistry, Loyola University Medical School, 1985 - 1987 Tryptase, A Novel Trypsin Like Rat Skin Enzyme: Isolation and Purification
Kevin Wee, Department of Biology, Temple University, 1998 - 1999 Proteinases of Nematode Bacterial Parasites
 

COMMUNITY SERVICE ACTIVITIES:
1983 - 1985 S.E. Wisconsin Science and Engineering Fair-Judge
1985 - 1988 First Presbyterian Church, Oostburg, WI-Sunday School Teacher
1985 - 1988 New Berlin Public Schools-High Interest Day
1989 - 1991 Our Lords’ Methodist Church, New Berlin, WI-Sunday School Teacher
1989 - 1990 Waukesha County Career Exposition
1992 March of Dimes-Neighborhood Solicitor
 

NATIONAL/INTERNATIONAL MEETING MODERATOR/ORGANIZER:
1993 Organizer, Proteinase Interest Group Meeting, Control of proteolysis in the eye, Association for Research in Vision and Ophthalmology, Sarasota, FL
1994 Organizer, Proteinase Interest Group Meeting, Functional effects of proteolysis on proteins in the eye, Association For Research In Vision And Ophthalmology, Sarasota, FL
1994 Moderator, "Metalloproteinases" Poster Session, Association for Research in Vision and Ophthalmology, Sarasota, FL
1997 Moderator, "Extracellular Matrix", Platform Session, Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL
1998 Moderator, Pseudomonas Infections, Platform Session, Association For Research In Vision And Ophthalmology, Ft. Lauderdale, FL
2005 Organizer and Moderator, Corneal Nerves, Minisymposium, Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL
11/2006 Moderator, IRBP: A Journey Toward Understanding the Retina, A Tribute to Dr. Barbara Wiggert, NIH
2006 Co-organizer and Moderator, Proteases: Substrate Cleavage and Beyond, ICER, Buenos Aires, Argentina
2006 Organizer and Moderator, Scar Wars, Sunday Symposium, Association for Research in Vision and Ophthalmology, Ft. Lauderdale, FL


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. TWINING SS. Newman DS Radiotracer studies of metal metal ion exchange inhibition using organic inhibitors. J. Electrochem. Soc. ll9:l292 l297, l972
2. TWINING SS. Brecher AS. Isolation and identification of α1-antitrypsin as a component of normal and malignant human breast and other tissues. Proc. Soc. Exper. Biol. Med. 150:98-103, 1975
3. TWINING SS. Brecher AS. Identification of α1-acid glycoprotein, α2-macroglobulin and antithrombin III as components of normal and malignant human tissues. Clin.Chim. Acta. 75:143-148, 1977
4. TWINING SS. Brecher AS. Characterization of the interaction between chymotrypsin and heparin. Can. J. Biochem. 55:134-13109, 1977
5. TWINING SS. Brecher AS. Large scale separation of protease inhibitors from malignant human breast tissue. Mol. Cell. Biochem. 18:101-7, 1977
6. TWINING SS. LaPoint D. Brecher A.S. Interaction of mucopolysaccharides with chymotrypsin. Polymers 18:483-488, 1977
7. Newman DS. Frank C. Matlack RW. TWINING SS Kristnan V. The ionic Hall effect in the solid electrolyte C5H6N.AgI6, Electrochim. Acta 22: 811-814, 1977
8. TWINING SS. Atassi MZ. Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1. J. Biol. Chem. 253:5259-5262, 1978
9. Okuda K. Christadoss PR. TWINING SS Atassi MZ. David CS. Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control. J. Immunol. 121:866-868, 1978
10. Okuda K. TWINING SS. David CS. Atassi MZ. Genetic control of immune response to sperm whale myoglobin in mice. II. T lymphocyte proliferative response to the synthetic antigenic sites. J. Immunol. 123:182-188, 1979
11. TWINING SS. Atassi MZ. Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites. J. Immunol. Meth. 30:139-51, 1979
12. TWINING SS. Lehmann H. Atassi MZ. The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species. Biochem. J. 191:681-697, 1980
13. TWINING SS. Sealy RC. Glick DM. Preparation and activation of a spin-labeled pepsinogen. Biochemistry. 20:1267-72, 1981
14. TWINING SS. David CS. Atassi MZ. Genetic control of the immune response to myoglobin. IV. Mouse antibodies in outbred and congenic strains against sperm-whale myoglobin recognize the same antigenic sites that are recognized by antibodies raised in other species. Mol. Immunol. 18:447-450, 1981
15. TWINING SS. Lehmann H. Atassi MZ. Time-dependent study of the antibody response to sperm-whale myoglobin: recognition of the antigenic sites is unaltered over an extended period of immunization. Mol. Immunol. 18:473-479, 1981
16. Atassi MZ. TWINING SS. Lehmann H. David CS. Genetic control of the immune response to myoglobin. V. Analysis of the cross-reactivity of 12 myoglobins with sperm-whale myoglobin antisera of inbred mouse strains in terms of substitutions in the antigenic sites and in the environmental residues of the sites. Immunol. Commun. 10:359-365, 1981
17. Atassi MZ. Yokota S. TWINING SS. Lehmann H. David CS. Genetic control of the immune response to myoglobin. VI. Inter-site influences in T-lymphocyte proliferative response from analysis of cross-reactions of ten myoglobins in terms of substitutions in the antigenic sites and in environmental residues of the sites. Mol. Immunol. 18:945-948, 1981
18. TWINING SS. Alexander PA. Huibregtse K. Glick DM. A pepsinogen from rainbow trout. Comp. Biochem. Physiol. - B: Comp. Biochem. 75:109-112, 1983
19. TWINING SS. Huibregtse K. Glick DM. A pepsinogen from dog stomach. Comp. Biochem. Physiol. - B: Comp. Biochem. 75:103-107, 1983
20. TWINING S. Potts D. Burke J. Acid proteases of vitreal macrophages. Curr. Eye Res. 3:1055-1062, 1984
21. TWINING SS. Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes. Anal .Biochem. 143:30-34, 1984
22. TWINING SS. Hatchell DL. Hyndiuk RA. Nassif KF. Acid proteases and histologic correlations in experimental ulceration in vitamin A deficient rabbit corneas. Invest. Ophthalmol. Vis. Sci. 26:31-44, 1985
23. TWINING SS. Lohr KM. Moulder JE. The immune system in experimental Pseudomonas keratitis. Model and early effects. Invest. Ophthalmol. Vis. Sci. 27:507-515, 1986
24. Ripple RE. Lohr KM. TWINING SS. Hyndiuk RA. Caya JG. Role of leukocytes in ocular inflammation of tyrosinemia II. Invest. Ophthalmol. Vis. Sci. 27:926-931, 1986
25. TWINING SS. Davis SD. Hyndiuk RA. Relationship between proteases and descemetocele formation in experimental Pseudomonas keratitis. Curr. Eye Res.5:503-510, 1986
26. Burke JM. TWINING SS. Vitreous macrophage elicitation: generation of stimulants for pigment epithelium in vitro. Invest. Ophthalmol. Vis. Sci. 28:1100-1107, 1987
27. Burke JM. TWINING SS. Regional comparisons of cathepsin D activity in bovine retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 29:1789-1793, 1988
28. TWINING SS. †Everse SJ. Wilson PM. Yue BY. Chan SK. Localization and quantification of alpha-1-proteinase inhibitor in the human cornea. Curr. Eye Res. 8:389-395, 1989
29. TWINING SS. Wilson PM. Hatchell DL. Characterization of corneal proteoglycans under vitamin A deficiency. Biochim. Biophys. Acta. 992:181-190, 1989
30. Sawaguchi S. TWINING SS. Yue BY. Wilson PM. Sugar J. Chan SK. α-1 Proteinase inhibitor levels in keratoconus. Exp. Eye Res. 50:549-554, 1990
31. Kangas TA. Edelhauser HF. TWINING SS. O'Brien WJ. Loss of stromal glycosaminoglycans during corneal edema. Invest. Ophthalmol. Vis. Sci. 31:1994-2002, 1990
32. TWINING SS. Kirschner SE. Mahnke LA. Frank DW. Effect of Pseudomonas aeruginosa elastase, alkaline protease, and exotoxin A on corneal proteinases and proteins. Invest. Ophthalmol. Vis. Sci. 34:2699-712, 1993
33. Ando H. TWINING SS. Yue BY. Zhou X. Fini ME. Kaiya T. Higginbotham EJ. Sugar J. MMPs and proteinase inhibitors in the human aqueous humor. Invest. Ophthalmol. Vis. Sci. 34:3541-3548, 1993
34. Sawaguchi S. Yue BY. Kawa JE. Chang IL. TWINING SS. Meberg B. Lysosomal enzyme and inhibitor levels in the human trabecular meshwork Invest. Ophthalmol. Vis. Sci. 35:251-261, 1994
35. Brecher AS. TWINING SS. Brecknock BB. Friessen JA. Long J.E. Friedberg F. Organic solvents and Ca2+ influence the interaction of alkylating agents with chymotrypsin. Mol. Biol. (Life Sci. Adv.) 13:157-163, 1994
36. TWINING SS. Fukuchi T. Yue BY. Wilson PM. Boskovic G. Corneal synthesis of alpha 1-proteinase inhibitor (alpha 1-antitrypsin). Invest. Ophthalmol. Vis. Sci. 35:458-462, 1994
37. TWINING SS. Fukuchi T. Yue BY. Wilson PM. Zhou X.†Loushin G. α 2-Macroglobulin is present in and synthesized by the cornea. Invest. Ophthalmol. Vis. Sci. 35:3226-3233, 1994
38. TWINING SS. Fukuchi T. Yue BY. Wilson PM. Zhou X. α1-Antichymotrypsin is present in and synthesized by the cornea. Curr. Eye Res. 13:433-439, 1994
39. Sawaguchi S. TWINING SS. Yue BY. Chang SH. Zhou X. Loushin G. Sugar J. Feder RS. α 2-Macroglobulin levels in normal human and keratoconus corneas. Invest. Ophthalmol. Vis. Sci. 35:4008-4014, 1994
40. TWINING SS. Zhou X. Schulte DP. Wilson PM. Fish B. Moulder J. Effect of vitamin A deficiency on the early response to experimental Pseudomonas keratitis. Invest. Ophthalmol. Vis. Sci. 37:511-522, 1996
41. TWINING SS. Schulte DP. Wilson PM. Fish BL. Moulder JE. Retinol is sequestered in the bone marrow of vitamin A-deficient rats. J. Nutr. 126:1618-1626, 1996
42. Brecher AS. Hinko A. TWINING SS. A proposed sequence of reactions leading to collagen biosynthesis, fibrosis, and hypertension in alcoholics. J. Invest. Med. 44:36-41, 1996
43. TWINING SS. Schulte DP. Wilson PM. Zhou X. Fish BL. Moulder JE. Neutrophil cathepsin G is specifically decreased under vitamin A deficiency. Biochim. Biophys. Acta-Mol. Basis Dis. 1317:112-118, 1996
44. Zhou L. Yue BY. TWINING SS. Sugar J. Feder RS. Expression of wound healing and stress-related proteins in keratoconus corneas. Curr. Eye Res.15:1124-1131, 1996
45. Whitelock RB. Fukuchi T. Zhou L. TWINING SS. Sugar J. Feder RS. Yue BY. Cathepsin G, acid phosphatase, and α1-proteinase inhibitor messenger RNA levels in keratoconus corneas. Invest. Ophthalmol. Vis. Sci. 38:529-534, 1997
46. TWINING SS. Schulte DP. Wilson PM. Fish BL. Moulder JE. Vitamin A deficiency alters rat neutrophil function. J. Nutr. 127:558-565, 1997
47. TWINING SS. Schulte DP. Zhou X. Wilson PM. Fish BL. Moulder JE. Changes in rat corneal matrix metalloproteinases and serine proteinases under vitamin A deficiency. Curr. Eye Res.16:158-165, 1997
48. Boskovic G. TWINING SS. Retinol and retinaldehyde specifically increase α1-proteinase inhibitor in the human cornea. Biochem. J. 322:751-756, 1997
49. Li Y. Zhou L. TWINING SS. Sugar J. Yue BY. Involvement of Sp1 elements in the promoter activity of the α1-proteinase inhibitor gene. J. Biol. Chem. 273:9959-9965, 1998
50. Zhou L. Sawaguchi S. TWINING SS. Sugar J. Feder RS. Yue BY. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest. Ophthalmol. Vis. Sci. 39:1117-1124, 1998
51. Sawa T. Ohara M. Kurahashi K. TWINING SS. Frank DW. Doroques DB. Long T. Gropper MA. Wiener-Kronish JP. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infect. Immun. 66:3242-3249, 1998
52. Boskovic G. TWINING SS. Local control of α1-proteinase inhibitor levels: regulation of α1-proteinase inhibitor in the human cornea by growth factors and cytokines. Biochim. Biophys. Acta. -Mol. Cell Res. 1403:37-46, 1998
53. TWINING SS. Wilson PM. Ngamkitidechakul C. Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1α and -1β. Biochem. J. 339:705-712, 1999
54. Reiter SA. McGill CR. Lawrence SL. TWINING SS. Blood glucose laboratory for first-year medical students: an interdisciplinary model for nutrition-focused diabetes management. J Amer. Diet. Assoc. 100:570-572, 2000
55. Liu Z. Shapiro SD. Zhou X. TWINING SS. Senior RM. Giudice GJ. Fairley JA. Diaz LA. A critical role for neutrophil elastase in experimental bullous pemphigoid. J. Clin. Invest. 105:113-123, 2000
56. Olague-Marchan M. TWINING SS. Hacker MK. McGrath JA. Diaz LA. Giudice GJ. A disease-associated glycine substitution in BP180 (type XVII collagen) leads to a local destabilization of the major collagen triple helix. Matrix Biol. 19:223-233, 2000
57. Liu Z. Zhou X. Shapiro SD. Shipley JM. TWINING SS. Diaz LA. Senior RM. Werb Z. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell. 102:647-655, 2000
58. TWINING SS, Goryshin IY, Bhasin A, Reznikoff WS. Functional characterization of arginine 30, lysine 40 and arginine 62 in Tn5 transposase. J. Biol. Chem. 276, 23135-23143, 2001
59. Ngamkitidechakul C. Burke JM. O'Brien WJ. TWINING SS. Maspin: synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Invest. Ophthalmol. Vis. Sci. 42, 3135-3141, 2001
60. Ngamkitidechakul, C, TWINING SS. Buffered non-fermenter system for lab-scale production of secreted recombinant His-tagged proteins in Saccharomyces cerevisiae. Biotechniques, 33, 1296-1300, 2002
61. Ngamkitidechakul C, Warejcka DJ, Burke JM, O'Brien WJ, TWINING SS. Sufficiency of the reactive site loop of maspin for Induction of cell-matrix adhesion and inhibition of cell invasion: Conversion of ovalbumin to a maspin-like molecule. J Biol Chem. 278, 31796-31806, 2003
62. Cowell BA, TWINING SS. Hobden JA. Kwong MSF. Fleiszig SMJ. Mutation of LasA and LasB reduces Pseudomonas aeruginosa invasion of epithelial cells. Microbiology 2291-2299, 2003
63. Rogers CS, Chan L-M., Sims,YS, Byrd, KD, Hinton, DL, TWINING, SS. The effects of sub-solar levels of UV-A and UV-B on rabbit corneal and lens epithelial cells, Exp. Eye Res.1007-1014, 2004
64. Ayala A. Warjecka DJ. Vaughan K. Yue BYJT. TWINING, SS. The Fibrinolysis Inhibitor a2-Antiplasmin in the Human Cornea, Curr. Eye Res. 1097-1103, 2005
65. Warejcka DJ. TWINING, SS. Specific conformational changes of plasminogen induced by chloride ions, 6-aminohexanoic acid and benzamidine but not the overall openness of plasminogen, Biochem. J. 392, 703-712, 2005
66. Warejcka DJ. Vaughan KA. Bernstein AM. TWINING, SS. Differential conversion of plasminogen to angiostatin by human corneal cell populations, Mol. Vis. 47, 859-868, 2005
67. Marquart, M.E. Caballero, A.R.. Traidej, M, Thibodeaus, BA. TWINING, SS. O'Callaghan, RJ. Identification of a small secreted protease from Pseudomonas aeruginosa. Invest. Ophthalmol. Vis. Sci., 46, 3761-3768, 2005
68. Ayala A. Warejcka DJ., Olague-Marchan, M. TWINING, SS. Corneal activation of prothrombin to thrombin independent of vascular injury, Invest. Ophthalmol. Vis. Sci., 48, 134-143, 2007
69. Bernstein, AM,.TWINING, SS. Warejcka, DJ Tall, E. Masur, SK, Regulation of the Urokinase Pathway by Corneal Fibroblasts and Myofibroblasts, Mol. Biol. Cell, 18, 2716-2727, 2007
70. Horswill MA. Narayan M. Warejcka DJ. Cirillo LA TWINING SS, Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. Exp Eye Res. 86, 586-600, 2008 (Cancer Related)
71. Bohnsack RN. Patel M. Olson LJ. TWINING SS. Dahms NM. Residues Essential for Plasminogen Binding by the Cation-Independent Mannose 6-Phosphate Receptor. Biochemistry. 49, 635-644, 2010
72. White MJ. He H. Penoske RM. TWINING SS. and Zahrt TC. PepD participates in the Mycobacterial stress response mediated through MprAB and SigE. J.Bacteriol. 192,1498-510, 2010
73. Narayan M. Mirza SP. TWINING, SS. Identification of phosphorylation sites on extracellular corneal epithelial cell maspin. Proteomics. 11,1382-90, 2011. (Cancer Related)
74. Endsley MP. Hu Y. Deng Y. He X. Warejcka DJ. TWINING SS. Gonias SL. Zhang M. Maspin: the molecular bridge between the plasminogen activator system and β1 integrin that facilitates cell adhesion. J Biol Chem. 2011 online (Cancer Related)
75. Warejcka, DJ, Narayan, M, TWINING, SS, Maspin increases extracellular plasminogen activator activity associated with corneal fibroblasts and myofibroblasts, Exp. Eye Res., 2011, In press (Cancer Related)
 
Books, Chapters, and Reviews
1. TWINING SS. Wilson PM. Hyndiuk, RA. Proteases and proteoglycans in vitamin A deficiency the cornea: Transactions of the world congress of the cornea III, Raven Press, NY, NY, p. l2l l24, l988
2. Nauss KM. Ross AC. TWINING SS. Immunotrophic methodology. Meth. Enzymol. 190:259-73, 1990
3. TWINING SS. Wilson PM. Metal sensitive protease(s) associated with corneal proteoglycans. Matrix Suppl. 1:91-2, 1992
4. TWINING SS. Regulation of proteolytic activity in tissues. Crit. Rev. Biochem. Mol. Biol. 29:315-83, 1994
5. Reznikoff WS. Bhasin A. Davies DR. Goryshin IY. Mahnke LA. Naumann T. Rayment I. Steiniger-White M. TWINING SS. Tn5: A molecular window on transposition. Biochem.Biophys. Res. Commun. 266:729-34, 1999
6. Narayan, M. TWINING S. Focus on Molecules: maspin, Exp. Eye. Res. 90, 2-3, 2010.
 
Abstracts
1. l. SHINEW S. Newman DS. Radiotracer studies of metal metal ion exchange inhibition using organic inhibitors, Abstracts of the National Meeting of the Electrochemical Society, Cleveland, Ohio, 1971
2. Newman DS. Frank C. Matlack RW. TWINING SS. The ionic Hall effect in the solid electrolyte C5H6 NI.8AgI, Abstracts of the National Meeting of the Electrochemical Society, Chicago, Illinois, l973
3. TWINING SS. Brecher AS. Affinity chromatography of protease inhibitors in malignant human breast tissue, Abstracts of the American Chemical Society Meeting, Atlantic City, New Jersey, l974
4. TWINING SS. Brecher AS. Polyacrylamide disc gel electrophoresis evidence of a complex between chymotrypsin and heparin, Fed. Proc. 34, 2362, l975
5. TWINING SS. LaPointe D. Brecher AS. Interaction of mucopolysaccharides with chymotrypsin, Fed. Proc. 35, l445, l976
6. TWINING SS. Brecher AS. Large-scale separation of protease inhibitors from malignant human breast tissue, First Cleveland Symposium on Macromolecules, Cleveland, Ohio. l976
7. Okuda K. TWINING SS. Atassi MZ. David C. Genetic control of t lymphocyte proliferative response to sperm whale myoglobin and its synthetic antigenic sites in mice, Abstracts of the Fourth Ir Gene Workshop, Annapolis, Maryland, l978
8. TWINING SS. Sealy RC. Cataldi M. Glick DM. Electron spin resonance studies on the activation of pepsinogen, Fed. Proc. 39, l685, l980
9. TWINING SS. Increase in cathepsin D activity by human breast tissue components, Gordon Research Conference on Proteolytic Enzymes and their Inhibitors, Plymouth, New Hampshire, l980
10. l0. Glick DM. TWINING SS. Sealy RC. Some kinetic studies on pepsinogen activation, Gordon Research Conference on Proteolytic Enzymes and their Inhibitors, Plymouth, New Hampshire, l980
11. ll. TWINING SS. Huibregtse K. Glick DM. Purification of acid proteases from dog stomach, Fed. Proc. 40, l7l9, l98l
12. l2. TWINING SS. Alexander P. Glick DM. Characteristics of a new intermediate in pepsinogen activation, Fed. Proc. 4l, 762, l982
13. l3. TWINING SS. Hatchell DL. Proteases and protease inhibitors in normal and ulcerating vitamin a deficient rabbit corneas, Gordon Research Conference of Proteolytic Enzymes and their Inhibitors, Plymouth, New Hampshire, l982
14. l4. TWINING SS. Hatchell DL. Acid proteases in keratomalacia, Invest. Ophthalmol. Suppl. 24, 44, l983
15. l5. TWINING SS. Fluorescein isothiocyanate casein assay for proteolytic enzymes, Fed. Proc. 42, l95l, l983
16. l6. TWINING SS. Potts D. Burke JM. Acid proteases of vitreal macrophages, Invest. Ophthalmol. Vis. Sci. 25S, 207, l984
17. l7. Huntemann S. Essma JB TWINING SS. Effect of vitamin A deficiency on corneal aminopeptidases, Fed. Proc. 43, 2067, l984
18. l8. TWINING SS. Hatchell DL. Vitamin A and the Retinoids, Effects of vitamin A deficiency on corneal proteases, FASEB Conference on Micronutrients, Saxton River, Vermont, l984
19. l9. TWINING SS. Lohr KM. and Moulder JE. The immune system in Pseudomonas keratitis: model and early effects, Invest. Ophthalmol. Vis. Sci. 26S, 27l, l985
20. TWINING SS. Wilson PM., Isolation of a metalloprotease from normal rabbit cornea, l3th International Congress of Biochemistry, Amsterdam, l985
21. 2l. Burke JM. TWINING SS., Generation of growth and chemotaxis stimulants by elicitation of a macrophage invasion into rabbit vitreous, Invest. Ophthalmol. Vis. Sci. 27S, l88, l986
22. TWINING SS.Davis SD. Hyndiuk RA. Proteases and descemetoceles in experimental Pseudomonas keratitis, Invest. Ophthalmol. Vis. Sci. 27S, 209, l986
23. TWINING SS. Wilson PM., Corneal proteoglycan changes under vitamin a deficiency, Fed. Proc. 45, 2ll9,l986
24. TWINING SS. Wilson PM., Proteolytic susceptibility of corneal proteoglycans from normal and vitamin a deficient rabbits, Fed. Proc. 46, 2202, l987
25. TWINING SS. Wilson PM., Characterization of corneal protease inhibitors; localization of  l protease inhibitor in the cornea, Strangeways Research Laboratory 75th Anniversary Symposium on The Control of Tissue Damage, l987
26. TWINING SS. Everse SJ. and Chan S K. Presence of  l-protease inhibitor ( l antitrypsin) in the human cornea, Invest. Ophthalmol. Vis. Sci. 29S, l988
27. Burke JM. TWINING SS., Cathepsin D activity in bovine RPE: Comparison of cells from the posterior and equatorial regions, Invest. Ophthalmol. Vis. Sci. 29S, 90, l988
28. Kangas TA. Edelhauser HF. TWINING SS. O'Brien WJ. Loss of stromal proteoglycans during corneal edema, Invest. Ophthalmol. Vis. Sci. 29S, 2l5, l988
29. TWINING SS., Wilson PM. Yue B. Chan S-K.  l Proteinase inhibitor in the human cornea. Effect of keratoconus on the  l protease, Gordon Conference on Proteolytic Enzymes and Their Inhibitors, l988
30. TWINING SS., Kawczyinski RJ. Wilson PM. Moulder J. Fish B. McFadden P. Koethe S. Effect of Vitamin A deficiency on Pseudomonas aeruginosa infections and polymorphonuclear leukocyte function, FASEB Conference on the Retinoids, l988
31. 3l. TWINING SS., Kawczyinski RJ. McFadden P. Simultaneous quantification of phagocytosis and killing by leukocytes using fluorescence flow cytometry, J. Cell Biol. 107, 574a, l988
32. TWINING SS. Wilson PM., Isolation of corneal stromal proteoglycan-protease complexes, Invest. Ophthalmol. Vis. Sci. 30S, 205, 1989
33. Sawaguchi S. TWINING SS. Yue B. Wilson, PM. Sugar J. Alpha-1-proteinase inhibitor levels in keratoconus, Invest. Ophthalmol. Vis. Sci. 30S, 474, 1989
34. TWINING SS. Wilson PM., Metal-sensitive protease associated with corneal proteoglycans, matrix metalloproteinase Conference, Destin, Fla., 1989
35. TWINING SS. Wilson PM., Influence of polymorphonuclear leukocyte secreted products on degradation of corneal proteins and proteoglycans, Invest. Ophthalmol. Vis. Sci. 31S, 1990
36. Kirschner SE. TWINING SS. The effect of Pseudomonas aeruginosa exoproducts on corneal proteases, Invest. Ophthalmol. Vis. Sci. 31S, 1990
37. TWINING SS., Wilson PM. Zhou X. Synthesis of proteinase inhibitors in the cornea: immunoprecipitation of metabolically labeled proteins with monoclonal antibodies to -1-proteinase inhibitor and -2-macroglobulin, FASEB J. 5, A828, 1991
38. Friedberg F. TWINING SS. Brecknock BB. Long JE.Friesen J. Brecher AS. Chymotrypsin reactivity with alkylating agents is altered by solvent and ion effects, FASEB J. 5, A450, 1991
39. TWINING SS., Wilson PM. Zhou X. Identification of proteinase inhibitors in the cornea: -1-antichymotrypsin, -2-antiplasmin and -2-macroglobulin, Invest. Ophthalmol. Vis. Sci. 32S, 1071, 1999
40. TWINING SS., Wilson PM. ‡Zhou X. Presence and synthesis of serine proteinase inhibitors in the cornea, International Congress of Biochemistry, 1991
41. 41 Yue B. Loushin G. Sawaguchi S. TWINING S. Sugar J. 2-Macroglobulin levels in keratoconus, Invest. Ophthalmol. Vis. Sci. 33, 976. 1992
42. TWINING SS. Schulte DP. Effect of Vitamin A deficiency on neutrophil function in the cornea and in vitro, Invest. Ophthalmol. Vis. Sci. 34, 775, 1992
43. TWINING SS., Isolation and characterization of a new proteinase from Pseudomonas aeruginosa. Invest. Ophthalmol. Vis. Sci. 35, 847, 1993
44. Boskovic GD. TWINING SS., Effect of growth factors and cytokines on the expression of 1-proteinase inhibitor in the human cornea, FASEB J. 1993
45. TWINING SS. Boskovic GD. Stimulation of 1-proteinase inhibitor synthesis by cytokines and retinol, Invest. Ophthalmol. Vis. Sci. 35, 1994
46. TWINING SS. Zhou X. Wilson PM. Schulte DP. Effect of vitamin A deficiency on corneal proteinases, Invest. Ophthalmol. Vis. Sci. 36, S700, 1995
47. TWINING SS. Boskovic GD., Unique regulation of the synthesis of 1-proteinase inhibitor in the cornea, presented at the International Symposium on the Chemistry and Biology of SERPINS, Chapel Hill, NC, April 1996
48. TWINING SS. Schulte DP. Wilson PM. Retinol is sequestered in the bone marrow of Vitamin A deficient animals, Invest. Ophthalmol. Vis. Sci. 37, S853, 1996
49. TWINING SS. Corneal ulceration: disruption of the proteinase-inhibitor balance, Exp. Eye Res. 63, S17, 1996
50. Liu Z, TWINING SS Giudice GJ, Zhou X. Fairley JA. Diaz LA. Elastase plays a direct role in blister formation in experimental bullous pemphigoid, FASEB J. 10, A1407, 1996
51. TWINING SS. Wilson PM., Isolation and Characterization of human corneal serine proteinases, Invest. Ophthalmol. Vis Sci. 38, S3184, 1997
52. Yue B. Zhou L. Sawaguchi S, TWINING SS. Sugar J. Expression of degradative enzymes and protease inhibitors in keratoconus corneas, Invest. Ophthalmol. Vis Sci. 38, S4453, 1997
53. Li Y. Whitlock RB, TWINING SS, Sugar J. Yue B. Identification of regulatory elements in 1-proteinase inhibitor gene in releation to keratoconus, Invest. Ophthalmol. Vis Sci. 38, S5088, 1997
54. Liu Z. TWINING SS. Giudice GJ. Zhou X. Fairley JA. Troy JL. Diaz LA. Neutrophil elastase is essential for subepidermal blistering in experimental bullous pemphigoid, J. Invest. Derm. 108, 556A, 1997
55. TWINING SS. Ngamkitdechakul C. Nicholas M. Human corneal epithelial stromal and endothelial cells contain and synthesize the class II tumor suppressor maspin, Invest. Ophthalmol. Vis. Sci., 40, S393, 1999
56. Ngamkitdechakul C. TWINING SS., Non-epithelial synthesis of the tumor suppressor maspin in the human corneal, FASEB J., 13, A1538, 1999
57. TWINING SS., Sternard H. Angiostatin production by human corneal stromal cells, Invest. Ophthalmol. Vis. Sci. 41, S118, 2000
58. Sternard H, TWINING SS. Conversion of plasminogen to angiostatin-like molecules by corneal stromal cells, American Association for Cancer Research Meeting on Angiogenesis and Cancer, Traverse City, MI, 2000,
59. TWINING SS. Ngamkitdechakul C. Biological effects of the tumor suppressor maspin on corneal stromal cell movement and cell-extracellular matrix adhesion, Invest. Ophthalmol. Vis. Sci. 42, S279, 2001
60. Ngamkitdechakul C. Burke JM. O'Brien, WJ. TWINING SS. Identification of functional domain(s) of maspin for enhancement of corneal stromal cell adhesion to Type I collagen, Mol.Biol. Cell 12, 190a, 2001
61. TWINING SS. Olague-Marchan M. Ayala A. Evidence for an extravascular corneal coagulation system, Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 3202
62. TWINING SS. Ngamkitdechakul C. The RSL of maspin is required for induction of cell-matrix adhesion: conversion of ovalbumin to a maspin-like molecule. 3rd International Symposium on Serpin Biology Structure and Function, Chicago, IL, 2002
63. Warejcka DJ. TWINING SS. Benzamidine binding to plasminogen changes availability of cleavage sites for human plasminogen. Experimental Biology 2003, San Diego, CA, 2003
64. TWINING SS. Ngamkitidechakul C. O'Brien WJ. Burke JM. Sufficiency of the reactive site loop of maspin for induction of keratocyte-matrix adhesion: Conversion of ovalbumin to a maspin-like molecule. Invest. Ophthalmol. Vis. Sci. 2003 44: E-Abstract 871
65. TWINING SS. Vaughan, KA. Warejcka,DJ, Effects of maspin on corneal stromal cell gene expression: Increased protein levels of SPARC and PAI-1, Invest. Ophthalmol. Vis. Sci. 2004 45: E-Abstract 4551
66. Bernstein, AM. TWINING SS. Vaughan, KA. Masur SK, Urokinase pathway regulation in corneal fibroblasts and myofibroblasts, Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2304
67. TWINING SS. Warejcka, DJ. Bernstein AM. Corneal epithelial cells and stromal fibroblasts but not stromal myofibroblasts efficiency convert plasminogen to angiostatin, Invest. Ophthalmol. Vis. Sci. 2005 46: E-Abstract 2187
68. TWINING SS, Narayan M, Warejcka DJ, Berg T, and Horswill MA, Maspin Mediated Alteration of The Actin Cytoskeleton In Human Corneal Stromal Fibroblasts, Invest. Ophthalmol. Vis. Sci. 2006 47: E-Abstract 2980
69. TWINING SS, Warejcka DJ, Ayala A, Angiostatin formation and thrombin generation for activation of protease activated receptors and fibrin formation, International Congress of Eye Research, Buenos Aires, October 2006
70. TWINING SS, Warejcka, DJ. Maspin Increases Activation of Plasminogen by Corneal Stromal Fibroblasts and Myofibroblasts, American Society of Cell Biology, Annual Meeting, Washington, DC, December 2007
71. TWINING, SS, Warejcka, D.J., The Effect of Thrombin on the Plasminogen-Plasmin System in the Cornea. Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 2940
72. Narayan, M., Horswil, M.A., Warejcka, D.J., TWINING, SS, Regulation of Maspin Expression by DNA and Histone Methylation During Corneal Wound Healing, Invest. Ophthalmol. Vis. Sci. 2008 49: E-Abstract 3371
73. Denson K, Brown D, Duthie E, Sabina R, TWINING S, Derse A, Liard J., Teaching Geriatrics Outside the Clinics: Integrating Geriatrics into Basic Science, American Geriaritics Society National Meeting, Chicago, IL May 2009
74. Narayan M, Mirza, SP, TWINING SS., Identification of Phosphorylation Sites on Maspin Secreted by Corneal Epithelial Cells using Tandem Mass Spectrometry, Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 4603
75. Andreae EA, TWINING SS, Thrombin Induces the Expression of Cyr61 in Human Corneal Cells, Invest. Ophthalmol. Vis. Sci. 2009 50: E-Abstract 5698
76. Marcdante KA, TWINING, S.S., A Team Based Learning Approach to Translational Research, Conference of the Association of American Medical Colleges Central Group on Educational Affairs, Rochester MN March 2009
77. Andreae, EA, TWINING, S.S. Thrombin Affects Cyr61 Synthesis and Processing through Two Distinct Mechanisms, Invest. Ophthalmol. Vis Sci. 2010 51 E-abstract 1976
78. Narayan M, Mirza SP, TWINING SS, Differential Phosphorylation of Intracellular and Secreted Corneal Epithelial Cell Maspin, Invest. Ophthalmol. Vis Sci. 2010 51 E-abstract 1972
79. Andreae EA, Warejcka DJ, TWINING SS, Analysis of Thrombin Activity and Cyr61 Regulation in a Rat Cornea Organ Culture System, Invest. Ophthalmol. Vis Sci. 2011 52 E-abstract 2025