Medical College of Wisconsin
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CURRICULUM VITAE

Sang H. Lee PhD
Professor
Department of Pharmacology and Toxicology

OFFICE ADDRESS:
Basic Science Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

FACULTY APPOINTMENTS:
01/2005 - Present Assistant Professor, Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
02/2005 - Present Society for Neuroscience


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. LEE, S.H., Kim, J.C., Lee, M.S., Heo, W.D., Seo, H.Y., Yoon, H.W., Hong, J.C., Lee, S.Y., Bahk, J.D., Hwang, I., and Cho, M.J. (1995) Identification of a novel divergent calmodulin isoform from soybean which has differential ability to activate target enzymes. J. Biol. Chem. 270, 21806-21812.
2. LEE, S.H., Seo, H.Y., Kim, J.C., Heo, W.D., Chung, W.S., Lee, K.J., Kim, M.C., Cheong, Y.H., Choi, J.Y., Lim, C.O., and Cho, M.J. (1997) Differential activation of NAD kinase by plant calmodulin isoforms: the critical role of domain I. J. Biol. Chem. 272, 9252-9259.
3. Kim, C.Y., Gal, S.W., Choe, M.S., Jeong, S.Y., Lee, S.I., Cheong, Y.H., LEE, S.H., Choi, J.Y., Han, C.-d., Kang, K.Y., and Cho, M.J. (1998) A new class II chitinase, Rcht2, whose induction by fungal elicitor is abolished by protein phosphatase 1 and 2A inhibitor. Plant Mol. Biol. 37, 523-534.
4. Cho, M.J., Vaghy, P.L., Kondo, R., LEE, S.H., Davis, J.P., Rehl, R., Heo, W.D., and Johnson, J.D. (1998) Reciprocal regulation of nitric oxide synthase and calcineurin by plant calmodulin isoforms. Biochemistry 37, 15593-15597.
5. Heo, W.D., LEE, S.H.*, Kim, M.C., Kim, J.C., Chung, W.S., Lee, K.J., Park, C.Y., Choi, J.Y., and Cho, M.J. (1999) Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistant responses. Proc. Natl. Acad. Sci. U.S.A. 96, 766-771. *Co-first author.
6. LEE, S.H., M.C. Kim, W.D. Heo, J.C. Kim, W.S. Chung, C.Y. Park, H.C. Park, Y.H. Cheong, C.Y. Kim, S.-H. Lee, K.J. Lee, J.D. Bahk, S.Y. Lee, and M.J. Cho (1999) Competitive binding of calmodulin isoforms to calmodulin-binding proteins: Implication for the function of calmodulin isoforms in plants. Biochim. Biophys. Acta 1433, 56-67.
7. LEE, S.H., Johnson, J.D., Walsh, M.P., Van Lierop, J.E., Sutherland, C., Xu, A., Snedden, W., Kosk-Kosicka, D., Fromm, H., Narayanan, N., and Cho, M.J. (2000) Differential regulation of Ca2+/CaM-dependent enzymes by plant calmodulin isoforms and free Ca2+ concentration. Biochem. J. 350, 299-306.
8. Chung, W.S., LEE, S.H., Kim, J.C., Heo, W.D., Kim, M.C., Park, C.Y., Park, H.C., Lim, C.O., Kim, W.B., Harper, J.F., and Cho, M.J. (2000) Identification of a calmodulin-regulated soybean Ca2+-ATPase (SCA1) that is located in plasma membrane. Plant Cell 12, 1393-1407.
9. Lin, J.W., Ju, W., Foster, K., LEE, S.H., Ahmadian, G., Wyzynski, M.W., Wang, Y.T., and Sheng, M. (2000) Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internization. Nat. Neurosci. 3, 1282-1290.
10. Kim, J.C., LEE, S.H., Cheong, Y.H., Yoo, C-.M., Lee, S.I., Chun, H.J., Yun, D.-J., Hong, J.C., Lee, S.Y., Lim, C.O., and Cho, M.J. (2001) A novel cold-inducible zinc finger protein from soybean, SCOF-1, enhances cold tolerance in transgenic plants. Plant J. 25, 247-260.
11. LEE, S.H., Valtschanoff, J.G., Kharazia, V.K., Weinberg, R., and Sheng, M. (2001) Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. Neuropharmacology 41, 680-692.
12. Kim, M.C., LEE, S.H., Kim, J.K., Chun, H.J., Choi, M.S., Chung, W.S., Moon, B.C., Kang, C.H., Park, C.Y., Ok, H.M., Kang, Y.H., Koo, S.C., Koo, J.M., Jung, J.C., Kim, S.T., Schulze-Lefert, P., Lee, S.Y., and Cho, M.J. (2002) Mlo, a modulator of plant defense and cell death, is a novel calmodulin binding protein: Isolation and characterization of a rice Mlo homologue. J. Biol. Chem. 277, 19304-19314.
13. Choi, J.Y., LEE, S.H.*, Park, C.Y., Heo, W.D., Kim, J.C., Kim, M.C., Chung, W.S., Moon, B.C., Cheong, Y.H., Kim, C.Y., Yoo, J.H., Koo, J.C., Ok, H.M., Chi, S.-W., Ryu, S.-E., Lee, S.Y., Lim, C.O., and Cho, M.J. (2002) Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. J. Biol. Chem. 277, 21630-21638. *Co-first author.
14. LEE, S.H., Liu, L., Wang, Y.T., and Sheng, M. (2002) Clathrin adaptor AP2 and NSF interact with overlapping site of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36, 661-674.
15. Ahmadian, G., Ju, W., Liu, L., Wyszynski, M., LEE, S.H., Dunah, A.W., Taghibiglou, C., Wang, Y., Liu, J., Wong, T.P., Sheng, M., and Wang, Y.T. (2004) Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J. 23, 1040-1050.
16. LEE, S.H., Simonetta, A., and Sheng, M. (2004) Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 43, 221-236.
17. Fu, Z., LEE, S.H.*, Simonetta, A., Hansen, J., Sheng, M., and Pak, D. (2007) Rap small GTPases promote neurite and synapse elimination in hippocampal spiny neurons. J. Neurochem. 100, 118-131 *Co-first author.
18. Okamoto, K.-I., Narayanan, R., LEE, S.H., Murata, K., and Hayashi, Y. (2007) Role of CaMKII as a structural protein that bundles actin cytoskeleton in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 104, 6418-6423.
19. Kastning, K., Kukhtina, V., Kittler, J.T., Chen, G., Yan, Z., Enders, S., Pechstein, A., LEE, S.H., Sheng, M., and Haucke, V. (2007) Molecular determinants for the interaction of AMPA receptors and the clathrin adaptor complex AP-2. Proc. Natl. Acad. Sci. U.S.A. 104, 2991-2996.
20. Evers, D.M., Matta, J.A., Hoe, H.-S., Zarkowsky, D., LEE, S.H., Issac, J.T. and Pak, D.T.S. (2010) Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat. Neurosci. 13, 1199-1207.
21. Danielson, E., Zhang, N., Kaleka, K., Shin, S.M., Gerges, N., and LEE, S.H. (2012) S-SCAM is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. J. Neurosci. 32, 6967-6980.
22. Danielson, E., Metallo, J. and LEE, S.H. (2012) Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors. Channels (Austin) 6(5): 393-397.
23. Shin, S.M., Zhang, N., Hansen, J., Gerges, N.Z., Pak, D.T.S., Sheng, M., and LEE, S.H. (2012) GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Nat. Neurosci. 15, 1655-1666.
 
Books, Chapters, and Reviews
1. LEE, S.H., and Sheng, M. (2000) Development of Neuron-Neuron Synapses. Curr. Opin. Neurobiol. 10, 125-131.
2. Sheng, M. and LEE, S.H. (2000) Growth of the NMDA receptor industrial complex. Nat. Neurosci. 3, 633-635.
3. Sheng, M. and LEE, S.H. (2001) AMPA receptor trafficking and the control of synaptic transmission. Cell 105, 825-828.
4. Sheng, M. and LEE, S.H. (2003) AMPA receptor trafficking and synaptic plasticity: major unanswered questions. Neurosci. Res. 46, 127-134.