CURRICULUM VITAE
Sang H. Lee PhD
Sang H. Lee PhD
Professor
Department of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
FACULTY APPOINTMENTS: |
01/2005 - Present Assistant Professor, Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
02/2005 - Present Society for Neuroscience |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. LEE, S.H., Kim, J.C., Lee, M.S., Heo, W.D., Seo, H.Y., Yoon, H.W., Hong, J.C., Lee, S.Y., Bahk, J.D., Hwang, I., and Cho, M.J. (1995) Identification of a novel divergent calmodulin isoform from soybean which has differential ability to activate target enzymes. J. Biol. Chem. 270, 21806-21812. |
2. LEE, S.H., Seo, H.Y., Kim, J.C., Heo, W.D., Chung, W.S., Lee, K.J., Kim, M.C., Cheong, Y.H., Choi, J.Y., Lim, C.O., and Cho, M.J. (1997) Differential activation of NAD kinase by plant calmodulin isoforms: the critical role of domain I. J. Biol. Chem. 272, 9252-9259. |
3. Kim, C.Y., Gal, S.W., Choe, M.S., Jeong, S.Y., Lee, S.I., Cheong, Y.H., LEE, S.H., Choi, J.Y., Han, C.-d., Kang, K.Y., and Cho, M.J. (1998) A new class II chitinase, Rcht2, whose induction by fungal elicitor is abolished by protein phosphatase 1 and 2A inhibitor. Plant Mol. Biol. 37, 523-534. |
4. Cho, M.J., Vaghy, P.L., Kondo, R., LEE, S.H., Davis, J.P., Rehl, R., Heo, W.D., and Johnson, J.D. (1998) Reciprocal regulation of nitric oxide synthase and calcineurin by plant calmodulin isoforms. Biochemistry 37, 15593-15597. |
5. Heo, W.D., LEE, S.H.*, Kim, M.C., Kim, J.C., Chung, W.S., Lee, K.J., Park, C.Y., Choi, J.Y., and Cho, M.J. (1999) Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistant responses. Proc. Natl. Acad. Sci. U.S.A. 96, 766-771. *Co-first author. |
6. LEE, S.H., M.C. Kim, W.D. Heo, J.C. Kim, W.S. Chung, C.Y. Park, H.C. Park, Y.H. Cheong, C.Y. Kim, S.-H. Lee, K.J. Lee, J.D. Bahk, S.Y. Lee, and M.J. Cho (1999) Competitive binding of calmodulin isoforms to calmodulin-binding proteins: Implication for the function of calmodulin isoforms in plants. Biochim. Biophys. Acta 1433, 56-67. |
7. LEE, S.H., Johnson, J.D., Walsh, M.P., Van Lierop, J.E., Sutherland, C., Xu, A., Snedden, W., Kosk-Kosicka, D., Fromm, H., Narayanan, N., and Cho, M.J. (2000) Differential regulation of Ca2+/CaM-dependent enzymes by plant calmodulin isoforms and free Ca2+ concentration. Biochem. J. 350, 299-306. |
8. Chung, W.S., LEE, S.H., Kim, J.C., Heo, W.D., Kim, M.C., Park, C.Y., Park, H.C., Lim, C.O., Kim, W.B., Harper, J.F., and Cho, M.J. (2000) Identification of a calmodulin-regulated soybean Ca2+-ATPase (SCA1) that is located in plasma membrane. Plant Cell 12, 1393-1407. |
9. Lin, J.W., Ju, W., Foster, K., LEE, S.H., Ahmadian, G., Wyzynski, M.W., Wang, Y.T., and Sheng, M. (2000) Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internization. Nat. Neurosci. 3, 1282-1290. |
10. Kim, J.C., LEE, S.H., Cheong, Y.H., Yoo, C-.M., Lee, S.I., Chun, H.J., Yun, D.-J., Hong, J.C., Lee, S.Y., Lim, C.O., and Cho, M.J. (2001) A novel cold-inducible zinc finger protein from soybean, SCOF-1, enhances cold tolerance in transgenic plants. Plant J. 25, 247-260. |
11. LEE, S.H., Valtschanoff, J.G., Kharazia, V.K., Weinberg, R., and Sheng, M. (2001) Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors. Neuropharmacology 41, 680-692. |
12. Kim, M.C., LEE, S.H., Kim, J.K., Chun, H.J., Choi, M.S., Chung, W.S., Moon, B.C., Kang, C.H., Park, C.Y., Ok, H.M., Kang, Y.H., Koo, S.C., Koo, J.M., Jung, J.C., Kim, S.T., Schulze-Lefert, P., Lee, S.Y., and Cho, M.J. (2002) Mlo, a modulator of plant defense and cell death, is a novel calmodulin binding protein: Isolation and characterization of a rice Mlo homologue. J. Biol. Chem. 277, 19304-19314. |
13. Choi, J.Y., LEE, S.H.*, Park, C.Y., Heo, W.D., Kim, J.C., Kim, M.C., Chung, W.S., Moon, B.C., Cheong, Y.H., Kim, C.Y., Yoo, J.H., Koo, J.C., Ok, H.M., Chi, S.-W., Ryu, S.-E., Lee, S.Y., Lim, C.O., and Cho, M.J. (2002) Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. J. Biol. Chem. 277, 21630-21638. *Co-first author. |
14. LEE, S.H., Liu, L., Wang, Y.T., and Sheng, M. (2002) Clathrin adaptor AP2 and NSF interact with overlapping site of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36, 661-674. |
15. Ahmadian, G., Ju, W., Liu, L., Wyszynski, M., LEE, S.H., Dunah, A.W., Taghibiglou, C., Wang, Y., Liu, J., Wong, T.P., Sheng, M., and Wang, Y.T. (2004) Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J. 23, 1040-1050. |
16. LEE, S.H., Simonetta, A., and Sheng, M. (2004) Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 43, 221-236. |
17. Fu, Z., LEE, S.H.*, Simonetta, A., Hansen, J., Sheng, M., and Pak, D. (2007) Rap small GTPases promote neurite and synapse elimination in hippocampal spiny neurons. J. Neurochem. 100, 118-131 *Co-first author. |
18. Okamoto, K.-I., Narayanan, R., LEE, S.H., Murata, K., and Hayashi, Y. (2007) Role of CaMKII as a structural protein that bundles actin cytoskeleton in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 104, 6418-6423. |
19. Kastning, K., Kukhtina, V., Kittler, J.T., Chen, G., Yan, Z., Enders, S., Pechstein, A., LEE, S.H., Sheng, M., and Haucke, V. (2007) Molecular determinants for the interaction of AMPA receptors and the clathrin adaptor complex AP-2. Proc. Natl. Acad. Sci. U.S.A. 104, 2991-2996. |
20. Evers, D.M., Matta, J.A., Hoe, H.-S., Zarkowsky, D., LEE, S.H., Issac, J.T. and Pak, D.T.S. (2010) Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat. Neurosci. 13, 1199-1207. |
21. Danielson, E., Zhang, N., Kaleka, K., Shin, S.M., Gerges, N., and LEE, S.H. (2012) S-SCAM is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. J. Neurosci. 32, 6967-6980. |
22. Danielson, E., Metallo, J. and LEE, S.H. (2012) Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors. Channels (Austin) 6(5): 393-397. |
23. Shin, S.M., Zhang, N., Hansen, J., Gerges, N.Z., Pak, D.T.S., Sheng, M., and LEE, S.H. (2012) GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Nat. Neurosci. 15, 1655-1666. |
Books, Chapters, and Reviews |
1. LEE, S.H., and Sheng, M. (2000) Development of Neuron-Neuron Synapses. Curr. Opin. Neurobiol. 10, 125-131. |
2. Sheng, M. and LEE, S.H. (2000) Growth of the NMDA receptor industrial complex. Nat. Neurosci. 3, 633-635. |
3. Sheng, M. and LEE, S.H. (2001) AMPA receptor trafficking and the control of synaptic transmission. Cell 105, 825-828. |
4. Sheng, M. and LEE, S.H. (2003) AMPA receptor trafficking and synaptic plasticity: major unanswered questions. Neurosci. Res. 46, 127-134. |