CURRICULUM VITAE
Sridhar Rao MD, PhD
Sridhar Rao MD, PhD
Associate Professor
Department of Pediatrics
Division of Hematology and Oncology - Pediatrics
Department of Pediatrics
Division of Hematology and Oncology - Pediatrics
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-937-3841 |
Fax: 414-937-6284 |
Email: srrao@mcw.edu |
EDUCATION: |
09/1990 - 06/1994 BChE - Chemical Engineering, University of Minnesota, MN |
07/1994 - 06/2001 MD, University of Chicago, Chicago, IL |
07/1996 - 06/1999 PhD - Pathology, University of Chicago, Chicago, IL |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
07/01/2001 - 06/30/2004 Resident, Pediatrics, Children's Hospital, Boston, Boston, MA |
07/01/2004 - 06/30/2007 Clinical Fellow, Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA |
07/01/2005 - 11/30/2010 Research Fellow, Pediatric Oncology, Laboratory of Dr. Stuart H. Orkin, Dana Farber Cancer Institute, Boston, MA |
FACULTY APPOINTMENTS: |
07/2007 - 11/2010 Instructor, Department of Pediatrics, Harvard Medical School, Cambridge, MA |
12/2010 - Present Associate Investigator, Blood Research Institute, Stem Cell Biology Program, BloodCenter of Wisconsin, Milwaukee, WI |
07/01/2011 - 06/30/2018 Assistant Professor, Cell Biology, Neurobiology, and Anatomy, MCW, Milwaukee, WI |
08/01/2011 - 06/30/2018 Assistant Professor, Pediatrics, Hematology/Oncology/Transplantation, MCW, Milwaukee, WI |
07/01/2018 - Present Associate Professor, Pediatrics, Hematology, Oncology, Bone Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI |
07/01/2018 - Present Associate Professor, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
07/2007 - 11/2010 Attending, Pediatric Oncology, Division of Hematopoietic Stem Cell Transplantation, Dana Farber Cancer Institute, Boston, MA |
07/2007 - 11/2010 Attending, Medicine, Division of Hematology/Oncology, Children’s Hospital, Boston, MA |
07/01/2010 - Present Staff Physician, Pediatrics, Bone Marrow Transplantation, Children's Hospital of Wisconsin, Milwaukee, WI |
03/01/2020 - Present Medical Director-Radiation Injury Treatment Network, Children's Hospital of Wisconsin, Milwaukee, WI |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
2016 - Present Biology Chair-T2016-003, Therapeutic Advances in Childhood Leukemia (TACL) consortium, Los Angeles, CA |
2018 - Present Associate Program Director-MSTP Program, Medical College of Wisconsin |
HOSPITAL STAFF PRIVILEGES: |
07/2007 - 11/2010 Inpatient Attending, Hematopoietic Stem Cell Transplantation, Children's Hospital, Boston, MA |
07/2007 - 11/2010 Outpatient Attending, Hematopoietic Stem Cell Transplantation, Dana Farber Cancer Institute, Boston, MA |
12/2010 - Present Inpatient Attending, Hematopoietic Stem Cell Transplantation, Children's Hospital of Wisconsin, Milwaukee, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Certificates | Issued By | Issue Date | Expiration |
General Pediatrics | American Board of Pediatrics | 2004 | 2011 |
Pediatric Hematology/Oncology | American Board of Pediatrics | 2009 | 2021 |
Licensure | Number | Issue Date | Expiration |
Massachusetts Full Medical License | 2005 | None | |
Wisconsin Full Medical License | 55842-20 | 06/01/2011 | 10/31/2021 |
AWARDS AND HONORS: |
05/2001 AOA Membership, University of Chicago Pritzker School of Medicine |
06/2001 Graduation with Honors, University of Chicago Pritzker School of Medicine |
09/2011 Dr Richard Aster Award, Blood Research Institute, Milwaukee, WI |
2017 - 2018 Outstanding Graduate School Educator, MCW |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2007 - Present American Society of Hematology (Member) |
2007 - 2019 American Society of Blood and Marrow Transplantation (Member) |
2010 - Present International Society of Stem Cell Research (Member) |
2019 - Present American Association for Cancer Research (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
01/01/2020 - 12/31/2022 Blood |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
07/01/2020 - 06/30/2024 Permanent Member, Dev2 Study Section, NIH CSR |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
The role of Sall4 in Embryonic Stem Cell Pluripotency (Oral presentation of Abstract), ASBMT/CIMBTR tandem meetings, Orlando, FL, 2010 |
Genetic Interaction between Cohesin and
Driver Mutations in AML
Genetic Interaction between Cohesin and
Driver Mutations in AML
Genetic Interaction between Cohesin and
Driver Mutations in AML
Genetic interactions between cohesin and driver mutations in AML, American Society of Hematology, Myeloid Workshop, Orlando, Florida, 2019 |
National |
S Rao, Cohesin Mutations in AML, Invited Departmental Seminar, IUPUI-South Bend/Notre Dame, 2016 |
S Rao, Cohesin Mutations in AML, Invited Departmental Seminar, Northwestern University, Dept. of Cell Biology, 2017 |
Cohesin Mutations in AML, University of Michigan, Dept of Pathology Invited Seminar, Ann Arbor, Michigan, 2017 |
Cohesin Mutations in AML, Well's Center (IUPUI) Invited Seminar, Indianapolis, Indiana, 2018 |
Cohesin Mutations in AML, University of Pennsylvania, Hematopoiesis Research Affinity Group, Invited Lecture, Philadelphia, Pennsylvania, 2019 |
3D chromatin structure in development and leukemia, University of Wisconsin, Department of Cell Biology, Invited Seminar, Madison, Wisconsin, 2020 |
Regional |
Cohesin Mutations in AML, University of Milwaukee, Dept of Biology, Invited Seminar, Milwaukee, Wisconsin, 2019 |
Local |
The role of Sall4 isoforms in mESC pluripotency, Oral Presentation, Department of Pediatric Oncology, DFCI retreat, 2009 |
Identification of Master Regulators for Early Lineage Commitment, Oral Presentation, Harvard Stem Cell Institute retreat, 2009 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2011 - 2018 Member, Medical Scientist Training Program Admissions Committee, MCW |
09/01/2015 - 06/01/2017 Member, CBNA Search Committee |
2016 - 2017 Member, Section Chief Search, Hematology, Oncology, and Transplantations, Pediatrics |
07/01/2018 - Present Associate Director, Medical Scientist Training Program (MSTP) |
02/01/2020 - Present Co-Chair, MCW Research Culture Workgroup, Dean's Office, MCW |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2017 Tumor Immunology for M2 |
Graduate Student Education |
2014 - Present Advanced Stem Cell Biology |
2015 - 2020 Molecular Techniques, Introduction to RNA-seq |
2017 - Present Advanced Cell Biology |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
2010 - 2012 Jeremy Allred, Primary Research Mentor, Medical College of Wisconsin |
2012 - 2016 Jennifer Miksanek, Primary Research Mentor, Medical College of Wisconsin |
2015 - 2019 Emily Philips, Primary Research Mentor, Medical College of Wisconsin |
2016 - 2019 Lauren Engel, Primary Research Mentor, Medical College of Wisconsin |
2017 - 2021 John Brennan, Primary Research Mentor, Medical College of Wisconsin |
Graduate Students |
PhD Committees |
2012 - 2017 Cayla Lillge, GATA4 Regulates Regionalization Along the Small Intestine Epithelium., Medical College of Wisconsin |
2012 - 2014 Jamie Karcher, High Salt Diet Suppresses the Angiogenic Competency of Bone Marrow Mononuclear Cells in the Rat., Medical College of Wisconsin |
2013 - 2017 Amanda Urick, BMP Signaling and its Downstream Effector SMAD1 are Necessary for Hepatic Progenitor Cell Formation in hiPSCs, Medical College of Wisconsin |
2014 - 2018 Dan Schill, FoxO1 and FoxA1/2 interdependent and cooperative binding at insulin sensitive genes, Medical College of Wisconsin |
2014 - 2018 Michael Flinn, The Hippo pathway's role in zebrafish cardiac development and regeneration, Medical College of Wisconsin |
2014 - 2019 Matt Waas, Development, Validation, and Application of Strategies for Immunophenotyping Human Pluripotent Stem Cell-Derived Cardiomyocytes, Medical College of Wisconsin |
2014 - Present David Schauder, CD8 T cell differentiation during acute and chronic infections, Medical College of Wisconsin |
2015 - 2019 Kathleen Dixon, The Role of MyD88 in NK cell Maturation and Function, Medical College of Wisconsin |
2015 - Present Emily Gronseth, Medical College of Wisconsin |
2015 - 2019 Joshua Nord, A Role for Fox01 in Early Development, Medical College of Wisconsin |
2015 - Present Cheng-Yin Yuan, Medical College of Wisconsin |
2016 - 2018 Timothy Stodola, Structure and Function of the Genome within as SS-13BN Congenic Region, Medical College of Wisconsin |
2016 - 2019 Kathryn Hendee, Axenfeld-Rieger Syndrome:Insights from the Zebrafish Model, Medical College of Wisconsin |
2017 - Present Tiffany Claeys, Medical College of Wisconsin |
2017 - Present Theresa Bluemn, Medical College of Wisconsin |
2018 - Present Melissa Anfinson, Medical College of Wisconsin |
2018 - Present Nathan Eaton, Medical College of Wisconsin |
2018 - Present Benjamin O'Brien Hokanson, Medical College of Wisconsin |
2018 - Present Luke Christiansen, Medical College of Wisconsin |
2019 - Present Paystar Topchyan, Medical College of Wisconsin |
2019 - Present Yao Chen, Medical College of Wisconsin |
2020 - Present Kyle Stoltz, Medical College of Wisconsin |
2020 - Present Ao Mei, Medical College of Wisconsin |
2020 - Present Elaheh Hashemi, Medical College of Wisconsin |
2020 - Present Lishu He, Medical College of Wisconsin |
PhD Students Advised |
2013 - 2017 Steven Blinka, Transcribed cis-Regulatory Elements Differentially Regulate Neighboring Genes at the Nanog Locus, Medical College of Wisconsin |
2013 - 2019 Michael Reimer, Differential Roles of TET Proteins in mESC Pluripotency, Medical College of Wisconsin |
2017 - Present Puja Agarwal, Medical College of Wisconsin |
2017 - Present Katelyn Heimbruch, Medical College of Wisconsin |
Clinical/Research Fellows |
2011 - 2014 Samuel Milanovich, Primary Research Mentor, Medical College of Wisconsin |
2012 - 2014 Jonathan Roberts, MD, Scholarship Committee, MCW |
2017 - 2019 Lauren Pommert, Primary Research Mentor, Medical College of Wisconsin |
2018 - 2020 Tyce Kearl, Scholarship Oversight Committee, Medical College of Wisconsin |
2019 - 2021 Michael Halyko, Scholarship Oversight Committee, Medical College of Wisconsin |
2019 - Present Amanda Schusterman, Scholarship Oversight Committee, Medical College of Wisconsin |
2019 - 2021 Matthew Kudek, Scholarship Oversight Committee, Medical College of Wisconsin |
Faculty |
2018 - Present Karen Sue Carlson, Mentorship Committee Member, Medical College of Wisconsin |
2020 - Present Lauren Pommert, Primary Research Mentor, Medical College of Wisconsin |
Pharmacy Students |
2020 - Present Noe Somo, Primary Research Mentor, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Clinical/Research Fellows |
2015 - 2017 Joseph Fisher, Primary, Blood Research Institute |
AD HOC REVIEWER: |
06/2012 Dev2 Study Section (NIH) |
02/2013 Dev2 Study Section (NIH) |
11/2013 Dev2 Study Section (NIH) |
11/2013 SEP-PAR13-095(NIH) |
02/2014 SEP-PAR13-095(NIH) |
02/2015 SEP-PAR13-095(NIH) |
2016 Leukemia Research Foundation |
2016 NYSTEM reviewer |
2017 Dev2 Study Section |
THESIS: |
The Role of PU.1 and Spi-B in B-lymphocyte Function |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Sielaff, T., Hu, M., Rao, S., Groehler, K., Olson, D., Mann, H., Remmel, R., Shatford, R., Amiot, B., Bloomer, J., Hu, W., and Cerra, F. (1995). Gel-entrapment bioartificial liver therapy in galactosamine hepatitis. J. of Surgical Research 59, 179-184. |
2. Sielaff, T., Hu, M., Rao, S., Groehler, K., Olson, D., Mann, H., Remmel, R., Shatford, R., Amiot, B., Hu, W., and Cerra, F. (1995). A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture. Transplantation 59, 1459-1463 |
3. Garrett-Sinha, L., Su, G.H., Rao, S., Kabak, S., Hao, Z., Clark, M.R., and Simon, M.C. (1999). PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity 10, 399-408 |
4. Rao, S., Garrett-Sinha, L., Yoon, J., and Simon, M. C. (1999). The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J Biol Chem 274, 34245-52. |
5. Rao, S., Matsumura, A., Yoon, J., and Simon, M. C. (1999). SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. J Biol Chem 274, 11115-24. |
6. Garrett-Sinha, L.A, Dahl, R., Rao, S., and Simon, M.C. (2001) PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood 97, 2908-2912. |
7. Hu, C.J., Rao, S., Ramirez-Bergeron, D.L., Gerondakis, S., and Simon, M.C. (2001) PU.1/Spi-B regulation of c-rel¬ is essential for mature B cell survival. Immunity 15, 545-555 |
8. Dahl, R., Ramirez-Bergeron, D.L., Rao, S., and Simon, M.C. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J 21, 2220-2230 |
9. Garrett-Sinha, L.A., Hou, P., Wang, D., Grabiner, B., Araujo, E., Rao, S. , Yun, T.J., Clark, E.A., Simon, M.C., Clark, M.R. (2005) Spi-1 and Spi-B control the expression of the Grap2 gene in B cells. Gene 20,134-146 |
10. Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D., Theunissen, T., Orkin, S.H.(2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 44, 364-368 |
11. Rao, S., Shao, Z., Roumiantsev, S., McDonald, L., Yuan, G., Orkin, S.H. (2010) Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency. MCB 30, 5364-80 |
12. Koh, K., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C.A., Mostoslavsky, G., Lahesmaa, R., Orkin, S.H., Rodig, S.J., Daley, G.Q., Rao, A. (2011) Tet1 and Tet2 regulate 5-hydroxymethlcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell, 8, 200-213. |
13. Gundry RL, Riordon DR, Tarasova Y, Chuppa S, Bhattacharya S, Juhasz O, Wiedemeier O, Milanovich S, Noto FK, Tchernyshyov I, Raginski K, Bausch-Fluck D, Tae HJ, Marshall S, Duncan SA, Wollscheid B, Wersto RP, Rao S, Van Eyk JE, Boheler KR. A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells. Mol Cell Proteomics. 2012 Aug;11(8):303-16. PMCID: PMC3412963 |
14. Pulakanti K, Pinello L, Stelloh C, Blinka S, Allred J, Milanovich S, Kiblawi S, Peterson J, Wang A, Yuan GC, Rao S. Enhancer transcribed RNAs arise from hypomethylated, Tet-occupied genomic regions. Epigenetics. 2013 Dec;8(12):1303-20. PMCID: PMC3933491 |
15. Boheler KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Bausch-Fluck D, Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B, Gundry RL. A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. Stem Cell Reports. 2014 Jul 08;3(1):185-203. PMCID: PMC4110789 |
16. Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S. Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. Exp Hematol. 2015 Jan;43(1):53-64.e1-8. PMCID: PMC4268405 |
17. Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP. Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation. Mol Cell Biol. 2015 Mar;35(6):1026-42 |
18. Stelloh C, Reimer MH, Pulakanti K, Blinka S, Peterson J, Pinello L, Jia S, Roumiantsev S, Hessner MJ, Milanovich S, Yuan GC, Rao S. The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. Epigenetics Chromatin. 2016;9:14. PMCID: PMC4832553 |
19. Swartz KL, Wood SN, Murthy T, Ramirez O, Qin G, Pillai MM, Rao S, Minella AC. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017 Jan 01;37(1). PMCID: PMC5192079 |
20. Thompson CA, Wojta K, Pulakanti K, Rao S, Dawson P, Battle MA. GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):422-446. PMCID: PMC5404030 |
21. Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ. CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood. 2016 Feb 11;127(6):675-80. PMCID: PMC4751021 |
22. Blinka S, Reimer MH Jr, Pulakanti K, Rao S. Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes. Cell Rep. 2016 Sep 27;17(1):19-28. PMCID: PMC5111363 |
23. Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S. The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9. Leukemia. 2017 Mar;31(3):712-719. PMCID: PMC5332284 |
24. Fisher JB, Pulakanti K, Rao S, Duncan SA. GATA6 is essential for endoderm formation from human pluripotent stem cells. Biol Open. 2017 Jul 15;6(7):1084-1095. PMCID: PMC5550920 |
25. Jing W, Gershan JA, Holzhauer S, Weber J, Palen K, McOlash L, Pulakanti K, Wesley E, Rao S, Johnson BD, Riese MJ. T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia. Cancer Res. 2017 Oct 15;77(20):5676-5686. |
26. Broglie L, Pommert L, Rao S, Thakar M, Phelan R, Margolis D, Talano J. Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis. Blood Adv. 2017 Aug 22;1(19):1533-1536. PMCID: PMC5728466 |
27. Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S. Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. J Vis Exp. 2018 Jan 15(131). PMCID: PMC5908645 |
28. Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ. Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8<sup>+</sup> T cells. J Leukoc Biol. 2018 Nov;104(5):883-893. PMCID: PMC6195461 |
29. Volk A, Liang K, Suraneni P, Li X, Zhao J, Bulic M, Marshall S, Pulakanti K, Malinge S, Taub J, Ge Y, Rao S, Bartom E, Shilatifard A, Crispino JD. A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. Cancer Cell. 2018 Nov 12;34(5):707-723.e7. PMCID: PMC6235627 |
30. Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL. Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. Virology. 2019 Jan 02;526:52-60. PMCID: PMC6875439 |
31. Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM. Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res. 2019 Jan 25;47(2):970-980. PMCID: PMC6344872 |
32. DeLaForest A, Di Furio F, Jing R, Ludwig-Kubinski A, Twaroski K, Urick A, Pulakanti K, Rao S, Duncan SA. HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II. Genes (Basel). 2018 Dec 28;10(1). PMCID: PMC6356828 |
33. Ray A, Khalil MI, Pulakanti KL, Burns RT, Gurski CJ, Basu S, Wang D, Rao S, Dittel BN. Mature IgD<sup>low/-</sup> B cells maintain tolerance by promoting regulatory T cell homeostasis. Nat Commun. 2019 Jan 14;10(1):190. PMCID: PMC6331566 |
34. Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson KS, Rao S, Wang D, Zhu N. Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. Blood Adv. 2019 May 14;3(9):1499-1511. PMCID: PMC6517669 |
35. Reimer M Jr, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, Rao S. Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression. BMC Dev Biol. 2019 Jul 08;19(1):16. PMCID: PMC6615237 |
36. Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S. Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. Nat Commun. 2019 Sep 02;10(1):3931. PMCID: PMC6718415 |
37. Gao C, Schroeder JA, Xue F, Jing W, Cai Y, Scheck A, Subramaniam S, Rao S, Weiler H, Czechowicz A, Shi Q. Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice. Blood Adv. 2019 Sep 24;3(18):2700-2711. PMCID: PMC6759737 |
38. Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S. <i>Mirc11</i> Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells. Cancer Immunol Res. 2019 Oct;7(10):1647-1662. PMCID: PMC7428857 |
39. Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y. Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms. Hypertension. 2020 Mar;75(3):859-868. PMCID: PMC7035167 |
40. Murthy T, Bluemn T, Gupta AK, Reimer M Jr, Rao S, Pillai MM, Minella AC. Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin. J Biol Chem. 2018 Jun 29;293(26):10220-10234. PMCID: PMC6028971 |
41. Dausinas P, Pulakanti K, Rao S, Cole JM, Dahl R, Cowden Dahl KD. ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells. Gene. 2020 May 15;738:144458. PMCID: PMC7384259 |
42. Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S. Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. Elife. 2020 May 14;9. PMCID: PMC7255804 |
43. Fang C, Rao S, Crispino JD, Ntziachristos P. Determinants and role of chromatin organization in acute leukemia. Leukemia. 2020 Oct;34(10):2561-2575. PMCID: PMC7999176 |
44. Meyer AE, Furumo Q, Stelloh C, Minella AC, Rao S. Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation Neoplasia (United States). 2020. |
45. Meyer AE, Furumo Q, Stelloh C, Minella AC, Rao S. Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation. Neoplasia. 2020 Nov;22(11):644-658. PMCID: PMC7573506 |
46. Rao S. RUNX1 and inv(16) are frenemies in AML. Blood. 2020 Nov 19;136(21):2361-2362. PMCID: PMC7685212 |
47. Boucher A, Klopfenstein N, Hallas WM, Skibbe J, Appert A, Jang SH, Pulakanti K, Rao S, Cowden Dahl KD, Dahl R. The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages. J Immunol. 2021 Feb 01;206(3):540-553. PMCID: PMC7855803 |
48. Pommert L, Burns R, Furumo Q, Pulakanti K, Brandt J, Burke MJ, Rao S. Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia. Cancer Rep (Hoboken). 2021 Jun;4(3):e1335. PMCID: PMC8222551 |
49. Agrawal P, Blinka S, Pulakanti K, Reimer MH Jr, Stelloh C, Meyer AE, Rao S. Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment. J Biol Chem. 2021;296:100189. PMCID: PMC7948488 |
50. Agrawal P and Rao S. Super-enhancers and CTCF in early embryonic cell fate decisions. Frontiers in Cell and Developmental Biology. 2021 In press |
51. Heimbruch KE, Meyer AE, Agrawal P, Viny AD, Rao S. A cohesive look at leukemogenesis: the cohesin complex and other driving mutations in AML. Neoplasia. 2021 In press. |
52. Heimbruch KE, Meyer AE, Agrawal P, Viny AD, Rao S. A cohesive look at leukemogenesis: The cohesin complex and other driving mutations in AML. Neoplasia. 2021 Mar;23(3):337-347. PMCID: PMC7905235 |
53. Heimbruch KE, Fisher JB, Stelloh CT, Phillips E, Reimer MH Jr, Wargolet AJ, Meyer AE, Pulakanti K, Viny AD, Loppnow JJ, Levine RL, Pulikkan JA, Zhu N, Rao S. DOT1L inhibitors block abnormal self-renewal induced by cohesin loss. Sci Rep. 2021 Mar 31;11(1):7288. PMCID: PMC8012605 |
54. Agrawal P, Rao S. Super-Enhancers and CTCF in Early Embryonic Cell Fate Decisions. Front Cell Dev Biol. 2021;9:653669. PMCID: PMC8027350 |
55. Pisano M, Cheng Y, Sun F, Dhakal B, D'Souza A, Chhabra S, Knight JM, Rao S, Zhan F, Hari P, Janz S. Laboratory Mice - A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma. Front Immunol. 2021;12:667054. PMCID: PMC8206561 |
56. DeLaForest A, Kohlnhofer BM, Franklin OD, Stavniichuk R, Thompson CA, Pulakanti K, Rao S, Battle MA. GATA4 Controls Epithelial Morphogenesis in the Developing Stomach to Promote Establishment of Glandular Columnar Epithelium. Cell Mol Gastroenterol Hepatol. 2021;12(4):1391-1413. PMCID: PMC8479485 |
57. Nghiem-Rao TH, Pfeifer C, Asuncion M, Nord J, Schill D, Pulakanti K, Patel SB, Cirillo LA, Rao S. Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver. Sci Rep. 2021 Jun 11;11(1):12386. PMCID: PMC8196029 |
58. Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y. Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms. Hypertension. 2020 Mar;75(3):859-868. PMCID: PMC7035167 |
59. Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y. Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms. Hypertension. 2020 Mar;75(3):859-868. PMCID: PMC7035167 |
60. Pommert L, Schafer ES, Malvar J, Gossai N, Florendo E, Pulakanti K, Heimbruch K, Stelloh C, Chi YY, Sposto R, Rao S, Huynh VT, Brown P, Chang BH, Colace SI, Hermiston ML, Heym K, Hutchinson RJ, Kaplan JA, Mody R, O'Brien TA, Place AE, Shaw PH, Ziegler DS, Wayne A, Bhojwani D, Burke MJ. Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. Am J Hematol. 2022 May;97(5):613-622. PMCID: PMC8986610 |
61. Mammoto T, Hunyenyiwa T, Kyi P, Hendee K, Matus K, Rao S, Lee SH, Tabima DM, Chesler NC, Mammoto A. Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration. Front Bioeng Biotechnol. 2022;10:823642. PMCID: PMC8896883 |
62. Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM. Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol. Yale J Biol Med. 2022 Mar;95(1):45-56. PMCID: PMC8961707 |
63. O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD. Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus. iScience. 2022 Apr 15;25(4):104098. PMCID: PMC8980761 |
64. Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. Leukemia. 2022 Aug;36(8):2032-2041. PMCID: PMC9357218 |
65. Liang M, Cowley AW Jr, Greene AS, Geurts AM, Liu P, Liu Y, Rao S. Advancing Physiology with Expanded Multi-Omics. Function (Oxf). 2022;3(4):zqac031. PMCID: PMC9247404 |
66. Rao S, Carlson K. Mutant CALR's "sweet tooth". Blood. 2022 Sep 15;140(11):1187-1189. PMCID: PMC9479035 |
67. Rao S, Broglie L. HSCT for adults with immunodeficiencies. Blood. 2022 Oct 06;140(14):1580-1581. PMCID: PMC9707395 |
68. Kleman A, Singavi A, Pommert L, Mathison AJ, Hari P, Dhakal B, Mohan M, Janz S, Knight JM, Shah MV, Schinke C, Burns R, Steinhardt GF, Rao S, Carlson K. A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy. Blood Adv. 2023 Sep 26;7(18):5549-5553. PMCID: PMC10514068 |
69. Zorn KE, Cunningham AM, Meyer AE, Carlson KS, Rao S. Pediatric Myeloid Sarcoma, More than Just a Chloroma: A Review of Clinical Presentations, Significance, and Biology. Cancers (Basel). 2023 Feb 24;15(5). PMCID: PMC10000481 |
70. Rao S. The kids are alright: MDS clones mature. Blood. 2023 Mar 16;141(11):1243-1245. PMCID: PMC10163310 |
71. Liu Y, Huang J, Pandey R, Liu P, Therani B, Qiu Q, Rao S, Geurts AM, Cowley AW Jr, Greene AS, Liang M. Robustness of single-cell RNA-seq for identifying differentially expressed genes. BMC Genomics. 2023 Jul 03;24(1):371. PMCID: PMC10316566 |
72. Ray A, Stelloh C, Liu Y, Meyer A, Geurts AM, Cowley AW Jr, Greene AS, Liang M, Rao S. Histone Modifications and Their Contributions to Hypertension. Hypertension. 2024 Feb;81(2):229-239. PMCID: PMC11229175 |
73. Peramangalam PS, Surapally S, Veltri AJ, Zheng S, Burns R, Zhu N, Rao S, Muller-Tidow C, Bushweller JH, Pulikkan JA. N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia. Sci Adv. 2024 Mar;10(9):eadh8493. PMCID: PMC10901375 |
74. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Cell Rep. 2024 Mar 26;43(3):113897. PMCID: PMC11209755 |
75. Sekulovski N, Wettstein JC, Carleton AE, Juga LN, Taniguchi LE, Ma X, Rao S, Schmidt JK, Golos TG, Lin CW, Taniguchi K. Temporally resolved early BMP-driven transcriptional cascade during human amnion specification. bioRxiv. 2024 Mar 06. PMCID: PMC10942271 |
76. Hashemi E, McCarthy C, Rao S, Malarkannan S. Transcriptomic diversity of innate lymphoid cells in human lymph nodes compared to BM and spleen. Commun Biol. 2024 Jun 25;7(1):769. PMCID: PMC11199704 |
77. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Erratum: Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance (Cell Reports (2024) 43(3), (S2211124724002250), (10.1016/j.celrep.2024.113897)) Cell Reports. 23 July 2024;43(7). |
78. Sekulovski N, Wettstein JC, Carleton AE, Juga LN, Taniguchi LE, Ma X, Rao S, Schmidt JK, Golos TG, Lin CW, Taniguchi K. Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification. Elife. 2024 Jul 25;12. PMCID: PMC11272160 |
79. Boucher A, Murray J, Rao S. Cohesin mutations in acute myeloid leukemia. Leukemia. 2024 Sep 09. |
Books, Chapters, and Reviews |
1. Rao, S., and Simon, M. C. (2000). The role of PU.1 in B-lymphocyte development and function. In: Transcriptional regulation in normal and malignant hematopoiesis, J. Licht and K. Ravid, eds. (Boston: McGraw-Hill). |
2. Rao, S., Orkin, S.H., (2006) Unraveling the transcriptional network controlling ES cell pluripotency. Genome Biology 7, 230 |
3. Orkin, S. H. Wang, J., Kim, J., Chu, J., Rao, S., Theunissen, T.W., Shen, X., and Levasseur, D.N. in Cold Spring Harbor Symposia on Quantitative Biology Vol. LXXIII (Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory 2008) |
4. Wang, J., Trowbridge, J. J., Rao, S. & Orkin, S. H. Vol. StemBook.1.4.1 (eds B. E. Bernstein & I. Lemischka) (stembook.org, 2008). |
5. Rao S. Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers. J Stem Cell Res Ther. 2012 Jul 05;Suppl 10. PMCID: PMC3844140 |
6. Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S. IQGAP1: insights into the function of a molecular puppeteer. Mol Immunol. 2015 Jun;65(2):336-49. PMCID: PMC4480615 |
7. Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S. Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. Front Immunol. 2016;7:176. PMCID: PMC4863891 |
8. Blinka S, Reimer MH Jr, Pulakanti K, Pinello L, Yuan GC, Rao S. Identification of Transcribed Enhancers by Genome-Wide Chromatin Immunoprecipitation Sequencing. Methods Mol Biol. 2017;1468:91-109. PMCID: PMC5111358 |
9. Fisher JB, McNulty M, Burke MJ, Crispino JD, Rao S. Cohesin Mutations in Myeloid Malignancies. Trends Cancer. 2017 Apr;3(4):282-293. PMCID: PMC5472227 |
10. Blinka S and S Rao. Nanog Expression in Embryonic Stem Cells-an Ideal Model System to Dissect Enhancer Function
BioEssays. . |
11. Blinka S, Rao S. Nanog Expression in Embryonic Stem Cells - An Ideal Model System to Dissect Enhancer Function. Bioessays. 2017 Dec;39(12). PMCID: PMC5878941 |
12. Agrawal P, Heimbruch KE, Rao S. Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease. Compr Physiol. 2018 Dec 13;9(1):439-455. PMCID: PMC6566905 |
13. Tang J, Zhu N, Rao S, Carlson KS. Stem cell damage after chemotherapy- can we do better? Best Pract Res Clin Haematol. 2019 Mar;32(1):31-39. |
14. Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, Shen X, Levasseur DN. The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol. 2008;73:195-202. |
Editorials, Letters To Editor, Other |
1. A Meyer, S Rao, J Fisher. Cohesin mutations: contributors to myeloid malignancies
Oncotarget. . |
2. Rao S. Closing the loop on cohesin in hematopoiesis. Blood. 2019 Dec 12;134(24):2123-2125. PMCID: PMC6908834 |
