Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

CURRICULUM VITAE

Vera Tarakanova PhD
Associate Professor
Department of Microbiology and Immunology

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
BS - Medical Technology, University of Tennessee, Memphis, TN
PhD - Microbiology, Saint Louis University, St. Louis, MO
Postdoctoral Training, Washington University School of Medicine, Department of Pathology and Immunology

FACULTY APPOINTMENTS:
Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
1999 Scholarship Award, American Society of Clinical Pathologists
2002 - 2004 Predoctoral Fellowship, American Heart Association
2003 Graduate Student of the Year Award, Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine
2003 Scholar-in-Training Award, American Association for Cancer Research
2005 - 2008 Fellow, Leukemia and Lymphoma Society
2005 Edward A Smuckler Memorial Workshop: Patholobiology of Cancer, American Association for Cancer Research
2005 F32, joint sponsorship by NCI and NIAID, NIH/NRSA

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1998 - Present American Society for Microbiology

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
EMBO Journal, Antiviral Research
Virology
Plos Pathogens
Journal of Virology

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Source:
American Cancer Society
Role:
Principal Investigator
Dates:
07/01/2012 - 06/30/2014
 
Prior
Peer Review
Title:
Program Development Support for Vera Takakanova, PhD
Source:
Advancing a Healthier Wisconsin
Dates:
09/01/2008 - 08/31/2011
 
Title:
Immune Control of Chronic Gammaherpesvirus Infection in a Mouse Model of Ataxia-Telangiectasia
Source:
Cancer Center
Dates:
01/01/2010 - 12/31/2010
 
Title:
Pathogenesis of chronic gammaherpesvirus infection in ataxia telangiectasia
Source:
Concern Foundation
Dates:
07/01/2010 - 06/30/2011
 
Title:
The Role of Gammaherpesvirus Protein Kinase in Lytic and Latent Infection
Source:
NIH Allergy and Infectious Diseases
Dates:
09/01/2010 - 08/31/2011
 
Title:
Gammaherpesvirus Methyltransferase: A Novel Regulator of Virus-host Interactions
Source:
Research Affairs Committee
Dates:
01/01/2011 - 12/31/2011
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Regional
seminar speaker, Saint Louis University, 2011
Invited Speaker, University of Wisconsin/Madison/ 2012
 
National
Invited speaker, University of Massachussetts/Worcester/2013
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Graduate Student Education
Advanced Molecular Genetics
Microbiology, Immunology, and Molecular Genetics graduate program
Cellular Microbiology
Medical School: Medical Microbiology
Interdisciplinary graduate program: Classical and Molecular Genetics
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Joseph Kulinski, Medical College of Wisconsin
 
Graduate Students
MS Committees
Kristen Barr, Medical College of Wisconsin
Joe Kulinski, Medical College of Wisconsin
Michael Korrer, Medical College of Wisconsin
Bryan Mounce, Medical College of Wisconsin
Angela Henschel, Medical College of Wisconsin
Justin Reitsma, Medical College of Wisconsin
JP Savaryn, Medical College of Wisconsin
Dusanka Vesic, Medical College of Wisconsin
Steven Leonardo, Medical College of Wisconsin
Soonyean Hwang, Medical College of Wisconsin
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. (Tarakanova VL et al.) Virology 2010 Sep 15;405(1):50-61
2. MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. (Tarakanova VL et al.) Virology 2010 Jan 20;396(2):323-8
3. Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis. (Tarakanova VL et al.) Virus Res 2010 Jan;147(1):67-76
4. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. (Tarakanova VL et al.) Cell Host Microbe 2007 Jun 14;1(4):275-86
5. Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. (Tarakanova VL et al.) J Virol 2008 Jan;82(2):1034-9
6. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. (Tarakanova VL et al.) J Virol 2005 Dec;79(23):14668-79
7. Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription. (Xu X et al.) Virology 2003 Sep 1;313(2):615-21
8. Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. (Tarakanova VL et al.) J Virol 2003 Sep;77(17):9324-36
9. Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. (Toth K et al.) Cancer Gene Ther 2003 Mar;10(3):193-200
10. Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL. Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. Virology. 2011 Nov 25;420(2):73-81. PMCID: PMC3204369
11. Mboko WP, Mounce BC, Wood BM, Kulinski JM, Corbett JA, Tarakanova VL. Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. J Virol. 2012 Jun;86(12):6899-912. PMCID: PMC3393547
12. Mounce BC, Tsan FC, Kohler S, Cirillo LA, Tarakanova VL. Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells. Virology. 2011 Dec 20;421(2):167-72. PMCID: PMC3210866
13. Kulinski JM, Leonardo SM, Mounce BC, Malherbe L, Gauld SB, Tarakanova VL. Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection. J Virol. 2012 Dec;86(23):12826-37. PMCID: PMC3497635
14. Gauld SB, De Santis JL, Kulinski JM, McGraw JA, Leonardo SM, Ruder EA, Maier W, Tarakanova VL. Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells. Immunology. 2013 Jun;139(2):197-204. PMCID: PMC3647186
15. Kulinski JM, Tarakanova VL. Reply to "testing for herpesvirus infection is essential in children with chromosomal-instability syndromes". J Virol. 2013 Mar;87(6):3618. PMCID: PMC3592165
16. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol. 2013 Jul;87(13):7314-25. PMCID: PMC3700300
17. Tarakanova VL, Stanitsa E, Leonardo SM, Bigley TM, Gauld SB. Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. Virology. 2010 Sep 15;405(1):50-61.
18. Tarakanova VL, Molleston JM, Goodwin M, Virgin HW 4th. MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. Virology. 2010 Jan 20;396(2):323-8. PMCID: PMC2805278
19. Tarakanova VL, Wold WS. Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis. Virus Res. 2010 Jan;147(1):67-76. PMCID: PMC2794482
20. Tarakanova VL, Leung-Pineda V, Hwang S, Yang CW, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW 4th. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe. 2007 Jun 14;1(4):275-86. PMCID: PMC2034359
21. Tarakanova VL, Suarez F, Tibbetts SA, Jacoby MA, Weck KE, Hess JL, Speck SH, Virgin HW 4th. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol. 2005 Dec;79(23):14668-79. PMCID: PMC1287585
22. Tarakanova VL, Kreisel F, White DW, Virgin HW 4th. Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. J Virol. 2008 Jan;82(2):1034-9. PMCID: PMC2224605
23. Xu X, Tarakanova V, Chrivia J, Yaciuk P. Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription. Virology. 2003 Sep 01;313(2):615-21.
24. Tarakanova VL, Wold WS. Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. J Virol. 2003 Sep;77(17):9324-36. PMCID: PMC187388
25. Toth K, Tarakanova V, Doronin K, Ward P, Kuppuswamy M, Locke JE, Dawson JE, Kim HJ, Wold WS. Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. Cancer Gene Ther. 2003 Mar;10(3):193-200.
26. Sun X, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC. Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. J Virol. 2013 Sep;87(18):10126-38. PMCID: PMC3754017
27. Wood BM, Mboko WP, Mounce BC, Tarakanova VL. Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. Virology. 2013 Aug 15;443(1):123-33. PMCID: PMC3703304
28. Kulinski JM, Tarakanova VL, Verbsky J. Regulation of antiviral CD8 T-cell responses. Crit Rev Immunol. 2013;33(6):477-88. PMCID: PMC4729194
29. Mounce BC, Mboko WP, Kanack AJ, Tarakanova VL. Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. J Virol. 2014 Feb;88(4):2268-78. PMCID: PMC3911555
30. Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA. Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. J Biol Chem. 2014 Apr 18;289(16):11454-64. PMCID: PMC4036281
31. Mboko WP, Mounce BC, Emmer J, Darrah E, Patel SB, Tarakanova VL. Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells. J Virol. 2014 Jun;88(12):6993-7004. PMCID: PMC4054362
32. Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. J Virol. 2015 Jul;89(13):6562-74. PMCID: PMC4468508
33. Kulinski JM, Darrah EJ, Broniowska KA, Mboko WP, Mounce BC, Malherbe LP, Corbett JA, Gauld SB, Tarakanova VL. ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection. Virology. 2015 Sep;483:264-74. PMCID: PMC4516584
34. Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, Kulinski JM, Cui W, Dittel BN, Gauld SB, Tarakanova VL. Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. J Virol. 2015 Dec 30;90(6):2818-29. PMCID: PMC4810652
35. Lange PT, Darrah EJ, Vonderhaar EP, Mboko WP, Rekow MM, Patel SB, Sidjanin DJ, Tarakanova VL. Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection. J Virol. 2016 Jan 06;90(7):3342-54. PMCID: PMC4794672
36. Rekow MM, Darrah EJ, Mboko WP, Lange PT, Tarakanova VL. Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. Virology. 2016 May;492:140-4. PMCID: PMC4826794
37. Oleson BJ, Broniowska KA, Naatz A, Hogg N, Tarakanova VL, Corbett JA. Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. Mol Cell Biol. 2016 08 01;36(15):2067-77. PMCID: PMC4946431
38. Mboko WP, Rekow MM, Ledwith MP, Lange PT, Schmitz KE, Anderson S, Tarakanova VL. Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection. J Virol. 2017 Jan 01;91(1). PMCID: PMC5165188
39. Darrah EJ, Kulinski JM, Mboko WP, Xin G, Malherbe LP, Gauld SB, Cui W, Tarakanova VL. B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. J Virol. 2017 10 01;91(19). PMCID: PMC5599758
40. Darrah EJ, Stoltz KP, Ledwith M, Tarakanova VL. ATM supports gammaherpesvirus replication by attenuating type I interferon pathway. Virology. 2017 10;510:137-146. PMCID: PMC5570481
41. Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL. Correction for Mounce et al., "A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages". J Virol. 2018 01 01;92(1). PMCID: PMC5730793
42. Lange PT, Schorl C, Sahoo D, Tarakanova VL. Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication. mBio. 2018 07 17;9(4). PMCID: PMC6050960
43. Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL. Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. Virology. 2019 01 02;526:52-60. PMCID: PMC6875439
44. Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W. Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection. Nat Commun. 2018 11 28;9(1):5037. PMCID: PMC6261948
45. Lange PT, Jondle CN, Darrah EJ, Johnson KE, Tarakanova VL. LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells. J Virol. 2019 03 15;93(6). PMCID: PMC6401431
46. Darrah EJ, Jondle CN, Johnson KE, Xin G, Lange PT, Cui W, Olteanu H, Tarakanova VL. Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses. J Virol. 2019 04 15;93(8). PMCID: PMC6450124
47. Lange PT, Lagunoff M, Tarakanova VL. Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism. Viruses. 2019 01 29;11(2). PMCID: PMC6409581
48. Miller HE, Johnson KE, Tarakanova VL, Robinson RT. γ-herpesvirus latency attenuates Mycobacterium tuberculosis infection in mice. Tuberculosis (Edinb). 2019 05;116:56-60. PMCID: PMC6876742
49. Oleson BJ, Broniowska KA, Yeo CT, Flancher M, Naatz A, Hogg N, Tarakanova VL, Corbett JA. The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide. Mol Cell Biol. 2019 09 15;39(18). PMCID: PMC6712938
50. Johnson KE, Lange PT, Jondle CN, Volberding PJ, Lorenz UM, Cui W, Dittel BN, Tarakanova VL. B Cell-Intrinsic SHP1 Expression Promotes the Gammaherpesvirus-Driven Germinal Center Response and the Establishment of Chronic Infection. J Virol. 2019 12 12;94(1). PMCID: PMC6912115
51. Johnson KE, Tarakanova VL. Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime. Viral Immunol. 2020 05;33(4):316-326. PMCID: PMC7247026
52. Li J, Zhao J, Xu S, Zhang S, Zhang J, Xiao J, Gao R, Tian M, Zeng Y, Lee K, Tarakanova V, Lan K, Feng H, Feng P. Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import. Sci Adv. 2019 10;5(10):eaaw7373. PMCID: PMC6785261
53. Jondle CN, Johnson KE, Uitenbroek AA, Sylvester PA, Nguyen C, Cui W, Tarakanova VL. B Cell-Intrinsic Expression of Interferon Regulatory Factor 1 Supports Chronic Murine Gammaherpesvirus 68 Infection. J Virol. 2020 Jun 16;94(13). PMCID: PMC7307145
54. Jondle CN, Tarakanova VL. Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime. Curr Opin Virol. 2020 Aug 07;44:81-89.
55. Johnson KE, Aurubin CA, Jondle CN, Lange PT, Tarakanova VL. Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection. J Virol. 2020 Sep 23.
 

jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a